A small maf protein that forms dimers with NRF1 protein; NRF2 PROTEIN; and P45 NF-E2 PROTEIN. MafF complexes bind Maf recognition elements to regulate tissue-specific GENETIC TRANSCRIPTION.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A family of Maf Transcription Factors that lack activation domains. Small Maf proteins function as transcriptional repressors or form heterodimeric complexes to serve as transcriptional coactivators. Small Maf proteins include MafF, MafG, and MafK.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
MafG is a ubiquitously expressed small maf protein that is involved in CELL DIFFERENTIATION of ERYTHROCYTES. It dimerizes with P45 NF-E2 PROTEIN and activates expression of ALPHA-GLOBIN and BETA-GLOBIN.
A small Maf protein involved in differentiation of ERYTHROID CELLS. MafK was originally described as the small subunit of the NF-E2 Transcription Factor, but other small MAF PROTEINS also serve as NF-E2 subunits.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A plant genus of the family FABACEAE. This genus was formerly known as Tetragonolobus. The common name of lotus is also used for NYMPHAEA and NELUMBO.

Characterization of the murine mafF gene. (1/9)

Small Maf proteins are obligatory heterodimeric partner molecules of mammalian Cap'n'Collar proteins that together control a wide variety of eukaryotic genes. Although both MafK and MafG are expressed in overlapping but distinct tissue distribution patterns during embryonic development, the physiological consequences of loss-of-function mutations in either gene are modest. This suggested that compensation by the third small Maf protein, MafF, might be a major reason for such mild phenotypes and that further analysis of MafF might therefore provide important insights for understanding small Maf regulatory function(s). We therefore cloned, mapped, transcriptionally and developmentally characterized, and finally disrupted the mafF gene. We show that murine mafF is transcriptionally regulated by three different promoters and is most abundantly expressed in the lung. The lacZ gene inserted into the mafF locus revealed prominent expression sites in the gut, lung, liver, outflow tract of the heart, cartilage, bone membrane, and skin but not in hematopoietic cells at any developmental stage. Homozygous mafF null mutant mice were born in a normal Mendelian ratio and displayed no obvious functional deficiencies, indicating that MafF activity may be dispensable even in tissues where the expression of other small Maf proteins is quite low.  (+info)

Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development. (2/9)

TCF11 (also known as Nrf1 and LCR-F1) is a basic-region leucine-zipper (b-ZIP) transcription factor that is essential during embryonic development. We have carried out expression analysis at a number of developmental stages and find that while there is some localized elevated expression between 8 and 9 days post coitum (dpc), the gene is widely expressed with a constant level of mRNA transcripts detectable in all tissues and at all stages examined. However, this does not reflect the specific nature of a TCF11 mutant phenotype (EMBO J. 17 (1998) 1779) which shows an essential role in foetal liver haematopoiesis. The specificity of TCF11 function may be controlled at a post-transcriptional level including availability of, and specific interaction with, a range of potential heterodimerization partners. We therefore carried out expression analysis of four candidate partner molecules; the three small Maf genes and another bZIP transcription factor found to bind to TCF11 in a two-hybrid screen, ATF4. We show different patterns of expression for the three Maf genes during development with MafG being widely expressed, MafK expressed only later in development and in specific tissues, and no detection of MafF. ATF4 shows evidence of complex regulation during development and shows elevated expression in many of the same sites as TCF11.  (+info)

Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators. (3/9)

The three small Maf proteins, MafF, MafG and MafK, have been implicated in a number of physiological processes, including development, differentiation, haematopoiesis and stress response. Here we report the constitutive expression of mafF, mafG and mafK in six human cell lines derived from various tissues (HepG2, IMR-32, K-562, HEK-293, RD and A549). The expression patterns of mafF, mafG and mafK varied widely among cell lines. Because small Maf proteins have been implicated in electrophile response element (EpRE)-mediated stress response, the ability of three EpRE activators [pyrrolidinedithiocarbamate (PDTC), phenylethyl isothiocyanate (PEITC) and t-butylhydroquinone (tBHQ)] to induce small Maf expression was examined in detail in HepG2 cells. Both PDTC and PEITC induced mafF, mafG and mafK expression, whereas tBHQ failed to markedly induce any of the three small Mafs. Where a response was observed, mafF was induced to the greatest extent compared with mafG and mafK, and this response was transcriptionally mediated. PDTC also induced small Maf expression in the other cell lines examined, with patterns of induction varying among cell lines. The differences in expression among the cell lines examined, coupled with the induction patterns observed, indicate that the three small maf genes are stress-responsive, but may be regulated via differing mechanisms. Furthermore, the fact that tBHQ, PDTC and PEITC induce EpRE activity, but that tBHQ fails to markedly induce any of the small Mafs, suggests that up-regulation of small Mafs is not an absolute requirement for EpRE-mediated gene expression.  (+info)

Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. (4/9)

While small Maf proteins have been suggested to be essential for the Nrf2-mediated activation of antioxidant response element (ARE)-dependent genes, the extent of their requirement remains to be fully documented. To address this issue, we generated mafG::mafF double-mutant mice possessing MafK as the single available small Maf. Induction of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene was significantly impaired in double-mutant mice treated with butylated hydroxyanisole, while other ARE-dependent genes were less affected. Similarly, in a keap1-null background, where many of the ARE-dependent genes are constitutively activated in an Nrf2-dependent manner, only a subset of ARE-dependent genes, including NQO1, were sensitive to a simultaneous deficiency in MafG and MafF. Examination of single and double small maf mutant cells revealed that MafK also contributes to the induction of ARE-dependent genes. To obtain decisive evidence, we established mafG::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs and turned out to be highly susceptible to oxidative stress. We found that induction in response to diethyl maleate was abolished in a wider range of ARE-dependent genes in the triple-mutant cells. These data explicitly demonstrate that small Mafs play critical roles in the inducible expression of a significant portion of ARE-dependent genes.  (+info)

Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. (5/9)

The MAF (proto-)oncogene family of basic-leucine zipper transcription factors plays crucial roles in the control of mammalian gene expression and development. Here we analyzed the regulation of the human MAFF gene, coding for a small MAF transcription factor, in uterine smooth muscle cells. We found that MAFF transcript levels are induced by proinflammatory cytokines in PHM1-31 myometrial cells. We observed an important induction by interleukin 1 beta (IL1B) and a weaker upregulation by tumor necrosis factor (TNF), whereas interleukin 6 (IL6) treatment had no effect. Time course experiments revealed a rapid induction of MAFF transcripts within 30 min following IL1B treatment. The presence of actinomycin D inhibited the upregulation, suggesting that regulation of MAFF mRNA levels occurs at the transcriptional level. We generated a MAFF-specific antiserum and determined that MAFF protein was also induced by TNF and IL1B in PHM1-31 cells. In contrast, it was particularly interesting that the transcript and protein levels of the highly homologous MAFG and MAFK genes are not modulated by these cytokines. Our results suggest a possible specific role for MAFF in proinflammatory cytokine-mediated control of myometrial gene expression and provide the first link between a small MAF transcription factor and the inflammatory response.  (+info)

Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins. (6/9)

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Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk. (7/9)

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Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. (8/9)

The human TCF11 gene encodes a ubiquitously expressed bZIP transcription factor of the cap n' collar (CNC) domain family. It has a high sequence similarity to the erythroid-specific bZIP factor p45 NF-E2 in the CNC domain, which is involved in DNA binding. LCR-F1, a TCF11 isoform, is a more potent transcriptional activator than p45 NF-E2 in erythroid cells. We show here that the TCF11 protein interacts to form heterodimers with small Maf proteins, previously shown to dimerize with p45 NF-E2, ECH and Fos. Such heterodimerization significantly alters the DNA binding characteristics of TCF11. While TCF11 alone binds in vitro to the tandem NF-E2 site derived from 5' DNase hypersensitive site 2 in the beta-globin locus control region and to the single NF-E2 site in the porphobilinogen deaminase gene promoter, stronger binding is detected in the presence of small Maf proteins. Using antibodies, TCF11 isoforms bound to the single NF-E2 site were detected in K562 erythroid cell nuclear extracts. These findings place TCF11 as a good candidate for the proposed widely expressed factor(s) known to interact with small Maf proteins and bind NF-E2 sites in a sequence-specific manner resembling NF-E2.  (+info)

MAFF (Musculoaponeurotic fibrosarcoma oncogene family, protein F) is a transcription factor that belongs to the basic leucine zipper (bZIP) family. It forms heterodimers with other bZIP proteins and binds to specific DNA sequences, regulating the expression of target genes. MAFF has been shown to play roles in various cellular processes such as cell survival, differentiation, and stress response. Dysregulation of MAFF has been implicated in several diseases including cancer and neurodegenerative disorders. However, a more specific medical definition of 'MafF Transcription Factor' is not available as it is a general term used to describe the function of the protein.

Transcription factors are proteins that play a crucial role in regulating gene expression by controlling the transcription of DNA to messenger RNA (mRNA). They function by binding to specific DNA sequences, known as response elements, located in the promoter region or enhancer regions of target genes. This binding can either activate or repress the initiation of transcription, depending on the properties and interactions of the particular transcription factor. Transcription factors often act as part of a complex network of regulatory proteins that determine the precise spatiotemporal patterns of gene expression during development, differentiation, and homeostasis in an organism.

Genetic transcription is the process by which the information in a strand of DNA is used to create a complementary RNA molecule. This process is the first step in gene expression, where the genetic code in DNA is converted into a form that can be used to produce proteins or functional RNAs.

During transcription, an enzyme called RNA polymerase binds to the DNA template strand and reads the sequence of nucleotide bases. As it moves along the template, it adds complementary RNA nucleotides to the growing RNA chain, creating a single-stranded RNA molecule that is complementary to the DNA template strand. Once transcription is complete, the RNA molecule may undergo further processing before it can be translated into protein or perform its functional role in the cell.

Transcription can be either "constitutive" or "regulated." Constitutive transcription occurs at a relatively constant rate and produces essential proteins that are required for basic cellular functions. Regulated transcription, on the other hand, is subject to control by various intracellular and extracellular signals, allowing cells to respond to changing environmental conditions or developmental cues.

MAF transcription factors are a family of proteins that regulate gene expression by binding to specific DNA sequences. "Small MAF" refers to a subgroup of this family that includes MAFG, MAFK, and MAFF. These proteins form heterodimers with other bZIP transcription factors, such as c-Maf, Nrf1, Nrf2, and Nrf3, and bind to antioxidant response elements (AREs) in the promoter regions of target genes. The small MAF proteins are involved in various cellular processes, including differentiation, proliferation, and stress responses, and have been implicated in several diseases, such as cancer and neurodegenerative disorders. They are called "small" because they contain a basic region-leucine zipper (bZIP) domain that is smaller than that of other MAF proteins.

Promoter regions in genetics refer to specific DNA sequences located near the transcription start site of a gene. They serve as binding sites for RNA polymerase and various transcription factors that regulate the initiation of gene transcription. These regulatory elements help control the rate of transcription and, therefore, the level of gene expression. Promoter regions can be composed of different types of sequences, such as the TATA box and CAAT box, and their organization and composition can vary between different genes and species.

DNA-binding proteins are a type of protein that have the ability to bind to DNA (deoxyribonucleic acid), the genetic material of organisms. These proteins play crucial roles in various biological processes, such as regulation of gene expression, DNA replication, repair and recombination.

The binding of DNA-binding proteins to specific DNA sequences is mediated by non-covalent interactions, including electrostatic, hydrogen bonding, and van der Waals forces. The specificity of binding is determined by the recognition of particular nucleotide sequences or structural features of the DNA molecule.

DNA-binding proteins can be classified into several categories based on their structure and function, such as transcription factors, histones, and restriction enzymes. Transcription factors are a major class of DNA-binding proteins that regulate gene expression by binding to specific DNA sequences in the promoter region of genes and recruiting other proteins to modulate transcription. Histones are DNA-binding proteins that package DNA into nucleosomes, the basic unit of chromatin structure. Restriction enzymes are DNA-binding proteins that recognize and cleave specific DNA sequences, and are widely used in molecular biology research and biotechnology applications.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Sp1 (Specificity Protein 1) transcription factor is a protein that binds to specific DNA sequences, known as GC boxes, in the promoter regions of many genes. It plays a crucial role in the regulation of gene expression by controlling the initiation of transcription. Sp1 recognizes and binds to the consensus sequence of GGGCGG upstream of the transcription start site, thereby recruiting other co-activators or co-repressors to modulate the rate of transcription. Sp1 is involved in various cellular processes, including cell growth, differentiation, and apoptosis, and its dysregulation has been implicated in several human diseases, such as cancer.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

MAFG (v-maf musculoaponeurotic fibrosarcoma oncogene homolog G) is a transcription factor that belongs to the large MAF family. Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences and controlling the initiation and rate of transcription of nearby genes.

The MAFG protein contains a basic leucine zipper (bZIP) domain, which is responsible for its ability to bind to DNA as a homodimer or heterodimer with other bZIP-containing proteins. The MafG protein can form heterodimers with the small MAF proteins (MAFF, MAFG, and MAFK) and the CNC family of basic leucine zipper transcription factors, including NFE2L1/Nrf1, NFE2L2/Nrf2, and BACH1/2.

MafG has been shown to play a role in various cellular processes, including oxidative stress response, inflammation, and cell differentiation. It can act as both an activator and repressor of transcription, depending on the context and the partners it interacts with. MafG is widely expressed in various tissues, including the liver, lung, kidney, and brain. Dysregulation of MafG has been implicated in several diseases, such as cancer, neurodegenerative disorders, and metabolic syndromes.

MAFK (Musculoaponeurotic fibrosarcoma oncogene homolog K) is a transcription factor that belongs to the basic region-leucine zipper (bZIP) family. Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences and controlling the initiation of transcription. The bZIP family of transcription factors is characterized by a highly conserved basic region for DNA binding and a leucine zipper domain for dimerization.

MAFK can form homodimers or heterodimers with other bZIP proteins, which allows it to regulate the expression of various genes involved in different cellular processes such as proliferation, differentiation, and stress response. Dysregulation of MAFK has been implicated in several diseases, including cancer, where it can act as an oncogene by promoting cell growth and survival.

MAFK is also known to play a role in the development and function of the nervous system. It is widely expressed in the brain, where it regulates the expression of genes involved in neuronal differentiation, synaptic plasticity, and neuroprotection. Mutations in MAFK have been associated with neurological disorders such as intellectual disability and epilepsy.

In summary, MafK transcription factor is a bZIP protein that regulates gene expression through DNA binding and dimerization. It plays important roles in cellular processes such as proliferation, differentiation, and stress response, and has been implicated in various diseases, including cancer and neurological disorders.

'Gene expression regulation' refers to the processes that control whether, when, and where a particular gene is expressed, meaning the production of a specific protein or functional RNA encoded by that gene. This complex mechanism can be influenced by various factors such as transcription factors, chromatin remodeling, DNA methylation, non-coding RNAs, and post-transcriptional modifications, among others. Proper regulation of gene expression is crucial for normal cellular function, development, and maintaining homeostasis in living organisms. Dysregulation of gene expression can lead to various diseases, including cancer and genetic disorders.

I'm sorry for any confusion, but the term "Lotus" does not have a specific medical definition in the context of human health or medicine. The lotus is a flowering plant that is often used as a symbol in various cultural and spiritual contexts, but it does not directly relate to medical terminology. If you have any questions related to medical topics, I'd be happy to help answer those!

Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene. MafF is one of ... Massrieh W, Derjuga A, Doualla-Bell F, Ku CY, Sanborn BM, Blank V (Apr 2006). "Regulation of the MAFF transcription factor by ... Massrieh W, Derjuga A, Doualla-Bell F, Ku CY, Sanborn BM, Blank V (Apr 2006). "Regulation of the MAFF transcription factor by ... type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFF is "v-maf avian musculoaponeurotic ...
Massrieh, W (2006). "Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells". Biol. ... The following genes encode small Maf proteins MAFF (Human), Maff (Mouse), maft renamed maff (Zebrafish) MAFG (Human), Mafg ( ... sMafs form homodimers by themselves and heterodimers with other specific bZIP transcription factors, such as transcription ... Shivdasani, RA (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of ...
Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription ... The Neh1 domain is a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins (MAFF, MAFG, MAFK). The Neh2 ... NRF2 is a basic leucine zipper (bZip) transcription factor with a Cap "n" Collar (CNC) structure. NRF2 possesses seven highly ... He F, Ru X, Wen T (January 2020). "NRF2, a Transcription Factor for Stress Response and Beyond". International Journal of ...
... may refer to: MAFF (gene), a transcription factor Malmö Arab Film Festival, held in Malmö (Sweden), the largest Arabic ... format provided by Firefox through an extension This disambiguation page lists articles associated with the title MAFF. If an ...
Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene. MafG is one of ... Finally, mice lacking MafF, MafG and MafK are embryonic lethal. Embryonic fibroblasts that are derived from Maff−/−::Mafg−/−:: ... Marini MG, Chan K, Casula L, Kan YW, Cao A, Moi P (Jun 1997). "hMAF, a small human transcription factor that heterodimerizes ... Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (Jun 1995). "Transcription factor NF-E2 ...
AP-1 fos/jun heterodimer that forms a transcription factor Jun-B transcription factor CREB cAMP response element transcription ... MAFF; MAFG; NRL; C-MAF; MAFK; NFE2; NFE2L2; NFE2L3; SNFT; XBP1 Ellenberger T (1994). "Getting a grip in DNA recognition: ... Proteins containing this domain are transcription factors. bZIP transcription factors are found in all eukaryotes and form one ... Plant Transcription Factor Database Plant bZIP transcription factors Archived 2012-03-20 at the Wayback Machine (Articles with ...
Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene. MafK is one of ... Mice lacking MafF, MafG and MafK are embryonic lethal. Embryonic fibroblasts that are derived from Maff−/−::Mafg−/−::Mafk−/− ... "Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene ... "The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that ...
"The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome- ... NFE2L1 binds DNA as heterodimers with one of small Maf proteins (MAFF, MAFG, MAFK). NFE2L1 has been shown to interact with C- ... Oh DH, Rigas D, Cho A, Chan JY (Nov 2012). "Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) ... Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that ...
... maff transcription factor MeSH D12.776.930.127.500.500.500 - mafg transcription factor MeSH D12.776.930.127.500.500.750 - mafk ... maff transcription factor MeSH D12.776.930.127.656.750.500 - mafg transcription factor MeSH D12.776.930.127.656.750.750 - mafk ... maff transcription factor MeSH D12.776.930.316.750.750.500 - mafg transcription factor MeSH D12.776.930.316.750.750.750 - mafk ... transcription factor brn-3b MeSH D12.776.930.632.625.875 - transcription factor brn-3c MeSH D12.776.930.635.600.100 - ets- ...
... maff transcription factor MeSH D12.776.260.108.500.500.500 - mafg transcription factor MeSH D12.776.260.108.500.500.750 - mafk ... maff transcription factor MeSH D12.776.260.108.656.750.500 - mafg transcription factor MeSH D12.776.260.108.656.750.750 - mafk ... maff transcription factor MeSH D12.776.260.235.750.750.500 - mafg transcription factor MeSH D12.776.260.235.750.750.750 - mafk ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.235.750.750 - maf transcription factors, small MeSH D12.776.260.235. ...
Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene. It is involved in ... Marini MG, Asunis I, Chan K, Chan JY, Kan YW, Porcu L, Cao A, Moi P (2003). "Cloning MafF by recognition site screening with ... Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (1995). "Transcription factor NF-E2 is ... Gavva NR, Gavva R, Ermekova K, Sudol M, Shen CJ (1997). "Interaction of WW domains with hematopoietic transcription factor p45/ ...
Sequence-specific interactions of a nuclear protein factor with the promoter of a rice gene for alpha-amylase, RAamy3D.. Nucl. ... MAFF. Retrieved September 26, 2020, from https://www.maff.go.jp/e/index.html Whitfield, J. (2002, April 5). Rice genome ... he developed specialized promoter-probe cloning vectors to better understand the regulation of bacterial transcription. In 1998 ... effective and affordable human growth factors for stem cell cures. On June 16, 2021, Osaka University awarded him an honorary ...
Overexpression of MAFG or MAFF in HUVECs significantly inhibited PA-induced early apoptosis. We identified MAFF and MAFG as ... The purpose of our study was to use a new generation high-throughput transcription factor (TF) detection method to identify ... MAFF), were matched to known AS signalling pathways and were validated by WB and RT-qPCR analyses in our study. ... Vascular endothelial cell apoptosis is the leading risk factor of atherosclerosis (AS). ...
Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene. MafF is one of ... Massrieh W, Derjuga A, Doualla-Bell F, Ku CY, Sanborn BM, Blank V (Apr 2006). "Regulation of the MAFF transcription factor by ... Massrieh W, Derjuga A, Doualla-Bell F, Ku CY, Sanborn BM, Blank V (Apr 2006). "Regulation of the MAFF transcription factor by ... type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFF is "v-maf avian musculoaponeurotic ...
Kannan, M. B., Solovieva, V. & Blank, V. The small MAF transcription factors MAFF, MAFG, and MAFK: current knowledge and ... The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 52, 953-968 (2006). ... Ding, Q., Joshi, P. S., Xie, Z. H., Xiang, M. & Gan, L. BARHL2 transcription factor regulates the ipsilateral/contralateral ... The alternative splicing factor Nova2 regulates vascular development and lumen formation. Nat. Commun. 6, 8479 (2015). ...
GADD45B, MAFF, and MYC were identified and validated as the hub genes. Finally, anisomycin and MG-262 were predicted to target ... GADD45B, MAFF, and MYC were identified and validated as the hub genes. Finally, anisomycin and MG-262 were predicted to target ... 2021). Transcription factor MAFF (MAF basic leucine zipper transcription factor F) regulates an atherosclerosis relevant ... MAFF, one of the basic region leucine zipper (bZIP)-type transcription factors, participates in transcriptional activation or ...
... transcription factor Maf family and is commonly downregulated in multiple cancers. But the expression and function of MafF in ... MafF is a member of the basic leucine zipper (bZIP) ... transcription factor Maf family and is commonly downregulated ... We found that MafF decreased in HCC tissues and cells. Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation ... This study verified that MafF acted as a tumor suppressor in HCC and revealed the upstream regulation mechanism of MafF, which ...
... tool that recognizes most important transcription factors that are changing their activity in a set of samples. ... First level regulatory network of Maff. In order to view interactive SVG image please either update your browser to latest ... fibroblast growth factor-activated receptor activity(GO:0005007). Gene overrepresentation in curated gene sets: canonical ... positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748). 0.1. 1.7. GO:0043552. positive ...
Journal Article] MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter2021. *. ...
Maf Transcription Factors, Small Maf, Transcription Factor use MafF Transcription Factor MafB Proteins use MafB Transcription ... Macrophage Chemotactic Factors use Chemotactic Factors Macrophage Colony Stimulating Factor Receptors use Receptor, Macrophage ... Macrophage Migration Inhibition Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Inhibition Test use ... Macrophage Migration Inhibitory Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Test use Cell ...
Maf Transcription Factors, Small Maf, Transcription Factor use MafF Transcription Factor MafB Proteins use MafB Transcription ... Macrophage Chemotactic Factors use Chemotactic Factors Macrophage Colony Stimulating Factor Receptors use Receptor, Macrophage ... Macrophage Migration Inhibition Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Inhibition Test use ... Macrophage Migration Inhibitory Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Test use Cell ...
Maf Transcription Factors, Small Maf, Transcription Factor use MafF Transcription Factor MafB Proteins use MafB Transcription ... Macrophage Chemotactic Factors use Chemotactic Factors Macrophage Colony Stimulating Factor Receptors use Receptor, Macrophage ... Macrophage Migration Inhibition Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Inhibition Test use ... Macrophage Migration Inhibitory Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Test use Cell ...
Maf Transcription Factors, Small Maf, Transcription Factor use MafF Transcription Factor MafB Proteins use MafB Transcription ... Macrophage Chemotactic Factors use Chemotactic Factors Macrophage Colony Stimulating Factor Receptors use Receptor, Macrophage ... Macrophage Migration Inhibition Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Inhibition Test use ... Macrophage Migration Inhibitory Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Test use Cell ...
Maf Transcription Factors, Small Maf, Transcription Factor use MafF Transcription Factor MafB Proteins use MafB Transcription ... Macrophage Chemotactic Factors use Chemotactic Factors Macrophage Colony Stimulating Factor Receptors use Receptor, Macrophage ... Macrophage Migration Inhibition Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Inhibition Test use ... Macrophage Migration Inhibitory Factors use Macrophage Migration-Inhibitory Factors Macrophage Migration Test use Cell ...
MAFF. 23764. MAFF. MAF bZIP transcription factor.... MAGOH. 4116. MAGOH. mago homolog, exon junction c.... ... TFT: Transcription Factor Targets TFT:GTRD: GTRD TFT:TFT_LEGACY: TFT_Legacy C4: Computational 3CA: Curated Cancer Cell Atlas ... general transcription factor .... GTF2H5. 404672. GTF2H5. general transcription factor .... HAX1. 10456. HAX1. HCLS1 associated ... KLF transcription factor 6 [S.... KLF9. 687. KLF9. KLF transcription factor 9 [S.... ...
In addition, we describe the transcription factors ZNF366 and MAFF as regulators of mo-DC development. Our results indicate ... Evaluation of transcription factors underlying these changes identified increased HIF-1 protein levels and activity in TKI- ... Using a computational approach, we identify candidate transcription factors potentially involved in monocyte fate commitment. ... Here, we identify Atg44 as a mitochondrial fission factor that is essential for mitophagy in yeasts, and we therefore term ...
... superfamily and are basic leucine zipper transcription factors. MafG, MafF and MafK belongs to small Mafs (approximately 150- ... The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target ... The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development. 2012; ... ZFHX4 is a transcription factor and has been shown to be associated with the maintenance of tumor-initiating cells in ...
Through RNA-sequencing analysis, we identified two transcription factors, MAFB and MAFF, positively regulated ACE2 expression ... In this study, we demonstrate that TRIB3 regulates the expression of PPARγ, a transcription factor that has gained attention ... including Mitochondrial transcription factor (TFAM) and Peroxisome proliferator-activated receptor alpha co-activator (PPARGC1A ... Reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and nitric oxide (NO), as well as the expression of the ...
AP-1 is a dimeric transcription factor composed of homodimers or heterodimers of members of the JUN (c-Jun, JunB and JunD), FOS ... Nrl and MafF/G.K) families of proteins. These proteins share a characteristic basic leucine zipper (bZIP) DNA-binding domain. ... The most studied form of AP-1 transcription factor is c-Jun/Fos heterodimer. Upon activation, this heterodimer binds a ... The variety of AP-1 dimer configurations confer versatility to this transcription factor in regulating numerous physiological ( ...
Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting ... Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting ... Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting ... Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting ...
Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network ... Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.. Biomolecules. ...
Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are ... Novel TFs, such as Thap6, Maff, (M1) and Hivep1, Nfil3, Prdm1, (M2) among others, were suggested to be involved in the ... Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are ... Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are ...
Transcription factors and regulatory mechanisms are proposed for these altered biological functions. ... Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact ... factors. Twenty-nine RF were found, some of them with known relationship with tissue development (MSTN, SIX4, IRX3), ... pathways and regulatory factors responsible for their phenotypic differences. Contemporary families coming from pure Iberian ...
Basic Helix-Loop-Helix Transcription ... A TALE-type homeodomain protein and transcription factor that functions as a regulator ... MafF complexes bind Maf ... PROTO-ONCOGENE PROTEIN C-CBL. HN - 2006(1989) BX - cbl Oncogene Protein BX - v-cbl Protein MH - ... The type I receptors activate Smad proteins that in turn act as transcription factors that regulate gene transcription. Sonic ... TATp is a transcription-activating factor with 86 amino acids that contains a highly basic (two Lys and six Arg among nine ...
S1.1m-r) are promoter sequences of a pectin lyase and an ERF/AP2 (Ethylene Responsive Factor/APETALA2) transcription factor, ... Mesorhizobium loti MAFF 303099 expressing DsRED [49] for L. japonicus infection experiments. Promoter expression analysis was ... The promoter regions pAtS5, pAtS32 and pAtS13 [6] of three Arabidopsis transcription factors belonging to bZIP (Basic Leucine ... Analysis of Arabidopsis transcription factor families revealed extensive capacity for cell-to-cell movement as well as discrete ...
Description transcription elongation factor A (SII), 3. P-value. FDR. R2. rAMP. Phase. ... Gene Symbol MAFF. Links Wikipedia HomoloGene. Unigene Hs.517617. RefSeq DNA NM_012323. NM_001161572. NM_001161573. NM_001161574 ...
Transcription Factor Class. (None) CAZymes. (None) Secondary Metabolism. (None) Expression data. No expression data available ... oryzae (strain MAFF 311018) GN=lldD PE=3 SV=1. 68. 438. 6.0E-53. ... PFAM domains CAZymes Transcription factors Secondary metabolism ...
Factor. Factor. AFF1 AFF1. AGO1 AGO1. AGO2 AGO2. ARHGAP35 ARHGAP35. ARID1B ARID1B. ... MAFF MAFF. MAFK MAFK. MAX MAX. MBD2 MBD2. MCM2 MCM2. MCM3 MCM3. ... Transcription Factor ChIP-seq Peaks (338 factors in 130 cell ... ENCODE Transcription Factor Binding Description. Transcription is regulated through the binding of transcription factor ... Transcription Factor Binding Sites by ChIP-seq from ENCODE/HAIB. SYDH TFBS Transcription Factor Binding Sites by ChIP-seq from ...
We conducted statistical analyses using a generalized linear mixed model to identify factors associated with CSF infection ... Factors associated with CSF infection. Table 2 summarizes the data of the 1824 animals used for the pre-vaccination statistical ... The PCR assay used for detection of CSFV was the reverse transcription PCR (RT-PCR) assay to amplify the 5′-unstranslated ... 1). The bait vaccines were imported from Germany by the Ministry of Agriculture, Forestry, and Fisheries (MAFF) of Japan and ...
... and predicted novel regulatory transcription factors. The lineage tree highlighted a prominent bifurcation between cortical and ... MAFF;HDAC10;CHD3;PKIG;RBM12;ERGIC1;ZNF221;LOC731275;RGS4;ABCG4;LIPE;DUSP23;ATP9B;DIS3L2;SGTA;WFS1;SUMO2;MTAP;NDRG2;C7orf68; ... and predicted novel regulatory transcription factors. The lineage tree highlighted a prominent bifurcation between cortical and ... and predicted novel regulatory transcription factors. The lineage tree highlighted a prominent bifurcation between cortical and ...
MAFF; neutrophil cytosolic factor 2, NCF2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, NFATC1; ... p53 can negatively regulate the transcription of a large number of genes (including BCL-2 and MCL1) that suppress apoptosis.22 ... MAFF; neutrophil cytosolic factor 2, NCF2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, NFATC1; ... p53 can negatively regulate the transcription of a large number of genes (including BCL-2 and MCL1) that suppress apoptosis.22 ...
... somatostatin transcription factor-1, upstream stimulatory factor-1, stress-activated protein kinase-2, phosphatidylinositol ... Livestock and poultry: number of farm households feeding livestock and number of livestock fed etc, MAFF. [cited 2018 Apr]. ... Previously, the main factors influencing nutrient partitioning between the dam and fetus were shown to include the age of the ... Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factors in over weight adolescents. J Pediatr 2003; ...
  • The HUGO Gene Nomenclature Committee-approved gene name of MAFF is "v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F". MafF was first cloned and identified in chicken in 1993 as a member of the small Maf (sMaf) genes. (wikipedia.org)
  • GADD45B, MAFF, and MYC were identified and validated as the hub genes. (frontiersin.org)
  • Other DEGs included 25 genes encoding transcription factors. (elsevierpure.com)
  • The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)
  • Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)
  • Similar to other sMafs, MafF lacks any canonical transcriptional activation domains. (wikipedia.org)
  • For example, some proteins activate transcription by recruiting RNA polymerase, some repress transcription by suppressing this recruitment, and others insulate proximal regions from the activity of nearby transcriptional activators or repressors. (ucsc.edu)
  • Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are commonly activated but have distinct activity dynamics in M1 and M2 activation. (edu.sa)
  • These motifs tend to be short and degenerate, so even when the DNA binding motif is known, one cannot generally predict where a given transcription factor may bind. (ucsc.edu)
  • MafF is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. (wikipedia.org)
  • MafF has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. (wikipedia.org)
  • MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. (techscience.com)
  • In this study, we investigated the relationship between endogenous MafF expression and HCC progression and explored the regulatory mechanism of MafF expression in HCC. (techscience.com)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • Mice lacking MafF, MafG and MafK are embryonic lethal, demonstrating that MafF is indispensable for embryonic development. (wikipedia.org)
  • Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact factors . (biomedcentral.com)
  • Transcription factors and regulatory mechanisms are proposed for these altered biological functions. (biomedcentral.com)
  • Transcription is regulated through the binding of transcription factor proteins to specific cis -level regulatory sites in the DNA. (ucsc.edu)
  • From the single-cell transcriptomic data a Bayesian algorithm generated a unified lineage tree, and predicted novel regulatory transcription factors. (uth.edu)
  • sMafs form homodimers by themselves and heterodimers with other specific bZIP transcription factors, such as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). (wikipedia.org)
  • Human MAFF gene is induced by proinflammatory cytokines, interleukin 1 beta and tumor necrosis factor in myometrial cells. (wikipedia.org)
  • AP-1 is activated by a variety of physiological and environmental stimuli such as growth factors, cytokines, stress, ultraviolet radiation, and bacterial and viral infections. (indigobiosciences.com)
  • Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene. (wikipedia.org)
  • This study verified that MafF acted as a tumor suppressor in HCC and revealed the upstream regulation mechanism of MafF, which provided a new perspective for potential therapeutic targets of HCC. (techscience.com)
  • The nature of this regulation depends on the transcription factor. (ucsc.edu)
  • With the appropriate analysis methods, ChIP-seq can be a valuable approach for elucidating transcription factor binding and cis -level regulation. (ucsc.edu)
  • MAFF is broadly but differentially expressed in various tissues. (wikipedia.org)
  • MAFF expression was detected in all 16 tissues examined by the human BodyMap Project, but relatively abundant in adipose, colon, lung, prostate and skeletal muscle tissues. (wikipedia.org)
  • We found that MafF decreased in HCC tissues and cells. (techscience.com)
  • Central to the ISR is a collection of related protein kinases that monitor stress conditions, such as Gcn2 (EIF2AK4) that recognizes nutrient limitations, inducing phosphorylation of eukaryotic translation initiation factor 2 (eIF2). (bvsalud.org)
  • A key characteristic of each transcription factor protein is its DNA binding domain. (ucsc.edu)
  • Jacks and colleagues analyzed the single-cell epigenome in a mouse model and found changes in epigenomic states from normal cells to different states of malignant cells with cancer progression, which was controlled by key transcription factors [ 5 ]. (biomedcentral.com)
  • Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation and induced cell apoptosis. (techscience.com)
  • The variety of AP-1 dimer configurations confer versatility to this transcription factor in regulating numerous physiological (cell proliferation, differentiation, apoptosis, migration) and pathological activities (cancer, inflammation, transplant rejection) in the cell. (indigobiosciences.com)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
  • The differentially regulated transcription factor Atf3 immunolocalized to supporting cells and hair cells in the organ of Corti at 12-h post-noise. (elsevierpure.com)
  • Transcription factors (TFs) function by recognizing and binding specific sequences to regulate gene expression. (biomedcentral.com)
  • This generally yields a large library of DNA sequences, including some that were bound by the transcription factor directly, some that were bound indirectly via interactions with other molecules, and some false positives (such as cases of nonspecific binding). (ucsc.edu)
  • But the expression and function of MafF in hepatocellular carcinoma (HCC) remain unclear. (techscience.com)
  • The rescue experiments further elucidated that the expression and antitumor effects of MafF could be regulated via the circ-ITCH/miR-224-5p axis. (techscience.com)
  • Bioinformatics analysis and luciferase assay identified MafF as a direct target of miR-224-5p. (techscience.com)
  • We find marked differences between the arterial and tail circulating metabolome, which arise from two major factors: handling stress and sampling site, whose effects were deconvoluted by taking a second arterial sample immediately after tail snip. (biomed.news)
  • BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)

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