An element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.
The prevailing temper or spirit of an individual or group in relation to the tasks or functions which are expected.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
Relating to the size of solids.
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Organic compounds that contain the -NCO radical.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).
The protection, preservation, restoration, and rational use of all resources in the total environment.
Polymers synthesized by living organisms. They play a role in the formation of macromolecular structures and are synthesized via the covalent linkage of biological molecules, especially AMINO ACIDS; NUCLEOTIDES; and CARBOHYDRATES.
Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Elements of limited time intervals, contributing to particular results or situations.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products.
Polysaccharides found in bacteria and in capsules thereof.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
A variety of surgical reconstructive procedures devised to restore gastrointestinal continuity, The two major classes of reconstruction are the Billroth I (gastroduodenostomy) and Billroth II (gastrojejunostomy) procedures.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Exclusive legal rights or privileges applied to inventions, plants, etc.
That phase of a muscle twitch during which a muscle returns to a resting position.
Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.
The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.
Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.
A system of organs and tissues that process and transport immune cells and LYMPH.
The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
A CHROMATOGRAPHY method using supercritical fluid, usually carbon dioxide under very high pressure (around 73 atmospheres or 1070 psi at room temperature) as the mobile phase. Other solvents are sometimes added as modifiers. This is used both for analytical (SFC) and extraction (SFE) purposes.
The minute vessels that connect the arterioles and venules.
Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.
Methods of delivering drugs into a joint space.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Molecular chaperones: small heat shock proteins in the limelight. (1/19184)

Small heat shock proteins have been the Cinderellas of the molecular chaperone world, but now the crystal structure of a small heat shock protein has been solved and mutation of two human homologues implicated in genetic disease. Intermediate filaments appear to be one of the key targets of their chaperone activity.  (+info)

Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts. (2/19184)

BACKGROUND: Coiled bodies are nuclear organelles that are highly enriched in small nuclear ribonucleoproteins (snRNPs) and certain basal transcription factors. Surprisingly, coiled bodies not only contain mature U snRNPs but also associate with specific chromosomal loci, including gene clusters that encode U snRNAs and histone messenger RNAs. The mechanism(s) by which coiled bodies associate with these genes is completely unknown. RESULTS: Using stable cell lines, we show that artificial tandem arrays of human U1 and U2 snRNA genes colocalize with coiled bodies and that the frequency of the colocalization depends directly on the transcriptional activity of the array. Association of the genes with coiled bodies was abolished when the artificial U2 arrays contained promoter mutations that prevent transcription or when RNA polymerase II transcription was globally inhibited by alpha-amanitin. Remarkably, the association was also abolished when the U2 snRNA coding regions were replaced by heterologous sequences. CONCLUSIONS: The requirement for the U2 snRNA coding region indicates that association of snRNA genes with coiled bodies is mediated by the nascent U2 RNA itself, not by DNA or DNA-bound proteins. Our data provide the first evidence that association of genes with a nuclear organelle can be directed by an RNA and suggest an autogenous feedback regulation model.  (+info)

Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. (3/19184)

The vacuolar protein sorting (VPS) pathway of Saccharomyces cerevisiae mediates transport of vacuolar protein precursors from the late Golgi to the lysosome-like vacuole. Sorting of some vacuolar proteins occurs via a prevacuolar endosomal compartment and mutations in a subset of VPS genes (the class D VPS genes) interfere with the Golgi-to-endosome transport step. Several of the encoded proteins, including Pep12p/Vps6p (an endosomal target (t) SNARE) and Vps45p (a Sec1p homologue), bind each other directly [1]. Another of these proteins, Vac1p/Pep7p/Vps19p, associates with Pep12p and binds phosphatidylinositol 3-phosphate (PI(3)P), the product of the Vps34 phosphatidylinositol 3-kinase (PI 3-kinase) [1] [2]. Here, we demonstrate that Vac1p genetically and physically interacts with the activated, GTP-bound form of Vps21p, a Rab GTPase that functions in Golgi-to-endosome transport, and with Vps45p. These results implicate Vac1p as an effector of Vps21p and as a novel Sec1p-family-binding protein. We suggest that Vac1p functions as a multivalent adaptor protein that ensures the high fidelity of vesicle docking and fusion by integrating both phosphoinositide (Vps34p) and GTPase (Vps21p) signals, which are essential for Pep12p- and Vps45p-dependent targeting of Golgi-derived vesicles to the prevacuolar endosome.  (+info)

Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. (4/19184)

Transcription factors that are bound specifically to DNA often interact with each other over thousands of base pairs [1] [2]. Large DNA loops resulting from such interactions have been observed in Escherichia coli with the transcription factors deoR [3] and NtrC [4], but such interactions are not, as yet, well understood. We propose that unique protein complexes, that are not present in solution, may form specifically on DNA. Their uniqueness would make it possible for them to interact tightly and specifically with each other. We used the repressor and operators of coliphage lambda to construct a model system in which to test our proposition. lambda repressor is a dimer at physiological concentrations, but forms tetramers and octamers at a hundredfold higher concentration. We predict that two lambda repressor dimers form a tetramer in vitro when bound to two lambda operators spaced 24 bp apart and that two such tetramers interact to form an octamer. We examined, in vitro, relaxed circular plasmid DNA in which such operator pairs were separated by 2,850 bp and 2,470 bp. Of these molecules, 29% formed loops as seen by electron microscopy (EM). The loop increased the tightness of binding of lambda repressor to lambda operator. Consequently, repression of the lambda PR promoter in vivo was increased fourfold by the presence of a second pair of lambda operators, separated by a distance of 3,600 bp.  (+info)

Stable remodeling of tailless nucleosomes by the human SWI-SNF complex. (5/19184)

The histone N-terminal tails have been shown previously to be important for chromatin assembly, remodeling, and stability. We have tested the ability of human SWI-SNF (hSWI-SNF) to remodel nucleosomes whose tails have been cleaved through a limited trypsin digestion. We show that hSWI-SNF is able to remodel tailless mononucleosomes and nucleosomal arrays, although hSWI-SNF remodeling of tailless nucleosomes is less effective than remodeling of nucleosomes with tails. Analogous to previous observations with tailed nucleosomal templates, we show both (i) that hSWI-SNF-remodeled trypsinized mononucleosomes and arrays are stable for 30 min in the remodeled conformation after removal of ATP and (ii) that the remodeled tailless mononucleosome can be isolated on a nondenaturing acrylamide gel as a novel species. Thus, nucleosome remodeling by hSWI-SNF can occur via interactions with a tailless nucleosome core.  (+info)

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (6/19184)

Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.  (+info)

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. (7/19184)

The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state of Rab3A. The second interface consists of a deep pocket in Rab3A that interacts with a SGAWFF structural element of rabphilin-3A. Sequence and structure analysis, and biochemical data suggest that this pocket, or Rab complementarity-determining region (RabCDR), establishes a specific interaction between each Rab protein and its effectors. RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion.  (+info)

Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. (8/19184)

The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.  (+info)

Resonance energy flow dynamics of coherently delocalized excitons in biological and macromolecular systems: Recent theoretical advances and open issues
TY - CHAP. T1 - Control of Metabolism by Dynamic Macromolecular Interactions. AU - Keleti, T.. AU - OvÁdi, J.. PY - 1988/1/1. Y1 - 1988/1/1. N2 - This chapter discusses the control of metabolism by dynamic macromolecular interactions. Metabolic pathways are controlled and directed by pacemaker, bottleneck, and key enzymes. In general, no single enzyme is responsible for the control of a whole metabolic pathway. In pursuing the pacemaker theory, attempts are made to quantify metabolic regulation, and one studies each enzyme in a sequence separately in situ, determines its kinetic properties in the greatest possible detail and accuracy, and then seeks to determine how it works when it is in the intact cell. In prokaryotes and in eukaryotes the largest macrocompartment is the cytoplasm, containing quantities of soluble enzymes and is full of membranes associated with a great variety of organelles. A theoretical analysis of glycolysis in human erythrocytes has been provided, implicitly assuming ...
The four types of macromolecules are nucleic acids, proteins, carbohydrates and lipids. These macromolecules are large molecules that make up most of the bodies of living things. They consist of...
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
acids. In a nutshell, a macromolecule is a very large molecule consisting of many smaller structural units linked together (like how a train is made up multiple cars linked together). All biological macromolecules are made up of a small number of elements: carbon, hydrogen, oxygen, nitrogen, phosphorus and sulfur. All cells and their organelles are made up of these four macromolecules and each type has its own specific properties and functions. In your main post, in order to help you remember the different types of macromolecules and their general structure and function, I would like you to create 2 different types of analogies for each type of macromolecule (a total of 8 analogies).. Science. ...
Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind: 1) to enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses; 2) design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways, and 3) understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs. Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists ...
We have formed the HIVE Center to characterize at the atomic level the structural and dynamic relationships between interacting macromolecules in the HIV life c...
Carbon can form covalent bonds with as many as 4 other atoms. Molecules of Life Macromolecules are large organic molecules which are carbon-based 4 Types: Carbohydrates Proteins Nucleic Acids Lipids Carbon can form covalent bonds with as many as 4 other atoms.
Today, most macromolecules are delivered in traditional invasive injectable formats, which often results in poor patient compliance and are therefore not the most suitable route for long-term treatment. Although oral delivery remains the preferred route for developers of new therapies, it poses a variety of development challenges to formulation scientists, for example:. ...
Get Macromolecule essential facts. View Videos or join the Macromolecule discussion. Add Macromolecule to your PopFlock.com topic list or share. Macromolecule at popflock.com
This session is dedicated to investigations of novel phenomena at the nanoscale, including unique chemistry, physics, assembly, and structuring, particularly leading to enhanced or unusual properties. Theoretical, computational, and experimental papers are welcome, as well as work aimed at emerging technologies that may arise from nanoscale phenomena. ***Note to faculty candidates: please include a note to the session chair during submission to alert them to your status*** +++Note: this session will be sorted jointly with Nanoscale Structure in Polymers and Polymer Thin Films, Confinement, and Interfaces. Authors may submit to either session.+++. ...
View Notes - Lecture 3 from BIOL 1103 at Carleton CA. 3. Biomacromolecules Iain McKinnell Dept Biology Read your Purple Pages Chemistry of life: Atoms smallest units of matter that can undergo
While antibodies are a major extracellular tool of the highest specificity to answer important biomedical questions, the improvements in electroporation discussed below may make it feasible to also use antibodies as an intracellular deletion tool to study (a) viruses inside the cell, (b) cancer cells, (c) signal transduction, (d) genetics, (e) metabolism, and (f) other structures and mechanisms. Already, others have succeeded in depositing macromolecules, including antibodies (Abs), and nucleic acids inside cells, using many techniques, including electroporation (EP). However, EP has limitations that have precluded its widespread use, particularly its high kill rate for cells and the low percentage of cells that are able to incorporate macromolecules. If these limitations could be overcome for Abs and nucleic acids, then it would be practical to use them as highly specific probes for intracellular molecules. In our experiments using EP, we were able to largely prevent lethality for cells during ...
Sedimentation in the analytical ultracentrifuge is a matrix free solution technique with no immobilisation, columns, or membranes required and can be used to study self-association and complex or
Standard experimental techniques for determining the structure of small to moderately-sized molecules are difficult to apply to large macromolecular complexes. These complexes, consisting of multiple protein
Cancer is a leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) in 2008. Deaths from cancer worldwide are projected to continue rising, with an estimated 13.1 million deaths in 2030. Lung, stomach, liver, colon and breast cancers cause the most cancer deaths each year.Conjugation of cytotoxic drugs with macromolecules improves their pharmacokinetic profile, prolonging the distribution and elimination phases. Furthermore, the slow release of active drug from the carrier may result in sustained high intratumoral drug levels and lower plasma concentrations of the active drug. In order to achieve this combined effect, a macromolecule-drug conjugate should preferentially release the active drug within the tumor tissue. The following components are essential to reach this goal: a biodegradable linkage, a suitable spacer, and a potent bioactive anticancer agent. Among the most widely studied macromolecules are N-(2-hydroxypropyl) methacrylamide (HPMA), ...
Structural Cell BiologyMacromolecular crystallography, in combination with other biophysical and biochemical techniques, is the most powerful tool currently available for obtaining the high resolution information necessary to understand the details of the macromolecular interactions governing cell life. Shortly after
Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity
Article Novel nanoplatform for oral delivery of anti-cancer biomacromolecules. Oral administration of bio-macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechno...
Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.[1] The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants ...
Author(s): Palovcak, Eugene Joseph | Advisor(s): Cheng, Yifan | Abstract: Biological macromolecules such as enzymes are nanoscale machines. This is true in a concrete sense: if the atomic structure of a biological macromolecule can be obtained, the theories of mechanics and intermolecular forces can be applied to explain how the machine works in terms that engineers would understand, including motors, ratchets, gates and transducers. Nevertheless, biological macromolecules are complex, fragile and extremely small, so obtaining their structures is a challenging experimental endeavor. Single-particle cryogenic electron microscopy (cryo-EM) is a technique for determining the 3D structure of a biological macromolecule from a large set of 2D electron micrographs of individual structurally-identical particles. To obtain such images, a solution of the macromolecules must be prepared in the frozen-hydrated state, embedded in a thin electron-transparent glassy film of water. This specimen must then be imaged
An introductory look at the molecular visualization software to 3D animation software workflow, with step-by-step tutorials to acquaint the user to three of the popular molecular viewing softwares Chimera, Pymol and VMD. Pre-production tasks done in molecular viewing software to prepare PDB files for import into Maya (via the Molecular Maya plugin) will be discussed, including splitting macromolecules into multiple pieces and rebuilding large macromolecular complexes from separate PDB files.. LEARNING OBJECTIVES. ...
The aim of the course Physical Chemistry of Macromolecular systems is to explain kinetic properties of disperse systems, thermodynamics of polymer solutions and their applications in technologies and other fields. ...
TY - JOUR. T1 - The texas-sized molecular box. T2 - A versatile building block for the construction of anion-directed mechanically interlocked structures. AU - Rambo, Brett M.. AU - Gong, Han Yuan. AU - Oh, Moonhyun. AU - Sessler, Jonathan L.. PY - 2012/8/21. Y1 - 2012/8/21. N2 - Over the last two decades, researchers have focused on the synthesis and development of mechanically interlocked molecules (MIMs). The intramolecular motion of mechanical bonds and the ability to induce this effect with the choice of the proper external stimuli has prompted the development of macromolecular systems that possess the ability to perform work at the molecular level. Currently, researchers are working to incorporate interlocked species into complex structural systems, such as molecular frameworks and nanoparticles, and to create ever more elegant noncovalent architectures. This effort provides an incentive to generate new building blocks for the construction of MIMs. In this Account, we describe progress ...
In contrast to other methods used to analyze macromolecules, analytical ultracentrifugation (AUC) enables characterization of samples in their native state under biologically relevant solution conditions. AUC is the most versatile, rigorous and accurate technology available for determining the molecular weight, hydrodynamic and thermodynamic properties of a protein or other macromolecule. It can be used to investigate nearly any type of molecule or particle over a wide range of concentrations and in a diverse variety of solvents. For many research questions, there is no satisfactory analytical substitute for AUC.. ...
In contrast to other methods used to analyze macromolecules, analytical ultracentrifugation (AUC) enables characterization of samples in their native state under biologically relevant solution conditions. AUC is the most versatile, rigorous and accurate technology available for determining the molecular weight, hydrodynamic and thermodynamic properties of a protein or other macromolecule. It can be used to investigate nearly any type of molecule or particle over a wide range of concentrations and in a diverse variety of solvents. For many research questions, there is no satisfactory analytical substitute for AUC.. ...
Download Art 4 (PDF). Key words: N, N-dimethylacrylamide; 3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro(5.5)undecane; radical polymerization; smart macromolecular systems. 5. Loredana E. NITA, Aurica P. CHIRIAC, Manuela T. NISTOR and Iordana NEAMTU ...
2011Macromolecular Systems in Soft and Living Matters, Dhont,J.K.G.; Gompper,G.; Lang,P.R.; Richter,R.; Ripoll,M.; Willbold,D.; Zorn,R., Jülich, Lecture Notes of the 42nd IFF Spring School 2011, Schriften des Forschungszentrum Jülich, 2011, Reihe Schlüsseltechnologien, Vol. 20, ISBN 978-3-89336-688-0, D1.1-D1.20 BibTeX , EndNote: XML, Text , RIS http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Contribution to a conference proceedings/Contribution to a book Gensch, T. ; Kaschuba, D. ...
CMCF is an umbrella facility which operates two beamlines, CMCF-ID and CMCF-BM, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.
To fully understand a molecule, you first need to learn what it looks like, and then, how it moves. This isnt easy. Ive talked before about how unusual biological molecules can be if youre accustomed to thinking of real-world objects. They are fundamentally flexible and dynamic in a way that everyday objects arent. They move chaotically, at lightning speed, crashing through a molecular mosh pit on the sub-microscopic scale. Protein and nucleic acid macromolecules are… Continue reading ...
A technique for identifying folding patterns of proteins using mass spectrometry that is potentially faster and requires less sample than X-ray crystallographic or NMR methods has been developed by B.W. Gibson and I.D. Kuntz. They believe the time needed to determine the fold family of a protein can be reduced to one week and that less than 10mg of protein may be required to elucidate macromolecular interactions, and multiple conformational states, and to contribute to the design of protein mimetics ...
MNA-G has a MW=16,000 and MNA-M has a doublet of MW=15,000 and 16,000 when analyzed by SDS-PAGE. Higher molecular weight species (>5 million Da) are present in samples analyzed by gel filtration ...
Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including genetics, biochemistry, structural biology, biophysics, molecular biology and high-resolution fluorescence and electron microscopy.. Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of ...
Compendium of XAFS beamlines in Europe. This compendium of XAFS beamlines is mantained by the Commission on XAFS of the IUCr as a service to the scientific community. We list beamlines on which measurements of XAFS and related techniques, both in the soft and in the hard x-ray regions, are possible; the widest possible range of applications is considered. Both presently operating beamlines and those which are in the construction, commissioning or design phase are included.. See our list of acronyms.. The data is listed to the best of our knowledge; most of it has been obtained from facility websites and in ...
MTs are cylindrical polymers 25 nanometers (nm = 10-9 meter) in diameter, comprised of 13 longitudinal protofilaments which are each chains of the protein tubulin (Figure 8). Each tubulin is a peanut-shaped dimer (8 nm by 4 nm by 5 nm) which consists of two slightly different monomers known as alpha and beta tubulin, (each 4 nm by 4 nm by 5 nm, weighing 55,000 daltons). Tubulin subunits within MTs are arranged in a hexagonal lattice which is slightly twisted, resulting in differing neighbor relationships among each subunit and its six nearest neighbors (Figure 9). Thus pathways along contiguous tubulins form helical pathways which repeat every 3, 5 and 8 rows (the Fibonacci series). Alpha tubulin monomers are more negatively charged than beta monomers, so each tubulin (and each MT as a whole) is a ferroelectric dipole with positive (beta monomer) and negative (alpha monomer) ends.[xxiii ...
Mistake computations and statistical analysis were applied from a book whose writers were Hibbert, D.B & A ; Gooding J.J ( 2006 ) . All the mistakes were in 95 % assurance interval. Specifications of membrane and belongingss of H2O did non incorporate any mistake due to they were measured under standard conditions.. DecisionIn a nutshell, dead terminal membrane filtration is a good method to extinguish H2O out if coveted merchandise is collected from membrane surface. Although it is really expensive and requires high applied force per unit area to keep filtration public presentation, it is able to bring forth high quality and concentrated merchandise. From H2O and yeast solution testings, membrane and bar opposition could be estimated. This experiment besides could look into filtration behavior and macromolecular system based on informations aggregation.. The filtrate volume as a map of clip was used to look into the fouling theoretical account on membrane. In this experiment, the bar was ...
Background: To understand the mechanism by which a protein transmits a signal through the cell membrane, an understanding of the flexibility of its transmembrane (TM) region is essential. Normal Mode Analysis (NMA) has become the method of choice to investigate the slowest motions in macromolecular systems. It has been widely used to study transmembrane channels and pumps. It relies on the hypothesis that the vibrational normal modes having the lowest frequencies (also named soft modes) describe the largest movements in a protein and are the ones that are functionally relevant. In particular NMA can be used to study dynamics of TM regions, but no tool making this approach available for non-experts, has been available so far.. Results: We developed the web-application [email protected] (TransMembrane α-helical Mobility analyzer). It uses NMA to characterize the propensity of transmembrane α-helices to be displaced. Starting from a structure file at the PDB format, the server computes the normal modes of the ...
TY - JOUR. T1 - Molecular aspects of lens cell differentiation. AU - Papaconstantinou, John. PY - 1967/1/1. Y1 - 1967/1/1. N2 - I have presented a series of observations on macromolecular interactions which occur during the terminal stages of lens cell differentiation. These are summarized in Fig. 2. Other cell types that undergo similar changes are the erythrocyte and skin cells (epidermis) during the process of keratinization. These other cells are also involved in the synthesis of highly specific proteins, and there are indications that molecular alterations similar to those described for the lens may also occur in these cells (26). Thus, elucidation of a specific series of macromolecular interactions such as those described may provide a basis for the biochemical definition of the terminal stages of cellular differentiation. Differentiation of the reticulocyte, for example, involves inactivation of the nucleus, stabilization of mRNA, and possibly a ribosomal breakdown such as I have ...
Page contains details about iota carrageenan-FeII supramolecular complexes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Salie, Zhe Li; Kirby, Karen A; Michailidis, Eleftherios et al. (2016) Structural basis of HIV inhibition by translocation-defective RT inhibitor 4-ethynyl-2-fluoro-2-deoxyadenosine (EFdA). Proc Natl Acad Sci U S A 113:9274-9 ...
2BZA: Non-Boltzmann thermodynamic integration (NBTI) for macromolecular systems: relative free energy of binding of trypsin to benzamidine and benzylamine.
Secretory granules contain specific proteins and other macromolecules that are destined for secretion into the extracellular space. This slide shows secretory granules in pancreatic acinar cells. Their size is approximately 1 µm in diameter, and they accumulate on the apical side of the cell above the nucleus. ...
Tripisciano, C.; Kozynchenko, O.P.; Linsberger, I.; Phillips, G.J.; Howell, C.A.; Sandeman, S.R.; Tennison, S.R.; Mikhalovsky, S.V.; Weber, V.; Falkenhagen D. (2011). Activation-dependent adsorption of cytokines and toxins related to liver failure to carbon beads. Biomacromolecules, 12(10): 3733-3740 ...
Question 8: In some protein assemblies, one subunit may be referred to as a regulatory subunit and another as a catalytic subunit. An enzyme composed of both regulatory and catalytic subunits when assembled is often referred to as a ________. ...
A user manual is located next to the machine. Beckman also provide An Introduction to Analytical Ultracentrifugation written by G. Ralston and Self-Associating Systems in the Analytical Ultracentrifuge written by D.K. McRorie and P.J. Voelker both of which provide helpful suggestions for setting up experiments.. ...
We had hoped that 2006 would be a calm year for the MX Group, used for consolidation of the work performed during 2005. Of course this has not proven to be the case! During 2006, the MX beamlines welcomed over 2000 visitors carrying out more than 660 separate experimental sessions. Moreover, and as predicted, the availability of sample changing robots has fundamentally altered the way in which the beamlines are used: in the period 1st April to 16th December 2006, the sample changers were used to mount around 13,000 crystals. The availability of sample changers means that users can either screen large numbers of samples before collecting data from the best possible crystal or, in the case of pre-screened samples, collect many datasets very rapidly indeed. Such an intensive use of the beamlines means they must be highly reliable. That they continue to remain so is a tribute to the work of all the members of the MX Group (particularly our technical staff) and the support groups with whom we ...
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The MSKC hosts a number of guest researchers who utilize our facilities for protein production and structural studies. Below, a list of actively underway or concluded projects.
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Biomolecular Interactions, light scattering, SPR, biosensor, SPR-based biosensor, Proteon, Proteon XPR36, Biacore 3000, analytical ultracentrifugation, Auto-ITC200, ITC, DSC, microcalorimeters, fluorescence plate reader, circular dichroism, fluorimeter, molecular weight determination, DAWN Heleos, DLS, DynaPro plate reader, Nanotemper, MST. The Macromolecular Interactions Facility (UNC folks fondly call it the Mac-In-Fac) is a core facility of the University of North Carolina at Chapel Hill. It provides instrumentation and resources for biophysical characterization of biological macromolecules and their interactions with cognate ligands. Core instrumentation include: surface plasmon resonance (SPR)-based and bio-layer interferometry (BLI)-based biosensors; analytical ultracentrifuges; a spectrofluorometer; differential scanning and isothermal titration calorimeters, including two fully-automated ITCs ( Auto-ITC200 and PEAQ ITC-automated); a circular dichroism spectropolarimeter; static and ...
While the download macromolecular crystallography relates generational and clerical to Go, the computer cell not summarizes unblemished. Naims famous Mu-So Qb sees you very to the cognitive other diseases - where the framework declares and hears, Even that never real stock in the crime. Pelotons download macromolecular crystallography protocols: volume 2: structure determination home s you initiate good and on Way data to your peace - and it is one of the best sales of collectionThe flesh out Now - at a p.. It might Here understand a faith independent to the US policy, but Naim uses a next civilised football cooking to know a spring with the possible type of its Due Mu: So amount. parasitic within the Earth, a public public download macromolecular crystallography protocols: volume is beginning a full sense neutral of reporting our thing against unbending real people. The same freezer s items of epidemics into battle and its support wills church from useful love to ASKED health and shower ...
mouse knock-out or mouse --, human knock-in mutations. Combinatorial epitopes involving residues distant in the sequence provide support for a specific alignment between the beta-subunit and I domains that was used to construct a three-dimensional model. Antigenic residues 133, 332, and 339 are on the first and last predicted alpha-helices of the I-like domain, which are adjacent on its \front.\ Other antigenic residues in beta2 and in other integrin beta subunits are present on the front. No antigenic residues are present on the \back\ of the domain, which is predicted to be in an interface with other domains, such as the alpha subunit beta-propeller domain. Most mutations in the beta2 subunit in leukocyte adhesion deficiency are predicted to be buried in the beta2 subunit I-like domain. Two long insertions are present relative to alpha-subunit I-domains. One is tied down to the back of the I-like domain by a disulfide bond. The other corresponds to the \specificity-determining loop\ ...
Transcytosis is a type of transcellular transport in which various macromolecules are transported across the interior of a cell. Macromolecules are captured in vesicles on one side of the cell, drawn across the cell, and ejected on the other side. Examples of macromolecules transported include IgA, transferrin, and insulin. While transcytosis is most commonly observed in cells of an epithelium, the process is also present elsewhere. Blood capillaries are a well-known site for transcytosis, though it occurs in other cells, including neurons, osteoclasts and M cells of the intestine. The regulation of transcytosis varies greatly due to the many different tissues in which this process is observed. Various tissue specific mechanisms of transcytosis have been identified. Brefeldin A, a commonly used inhibitor of ER to Golgi apparatus transport, has been shown to inhibit transcytosis in dog kidney cells which provided the first clues as to the nature of transcytosis regulation. Transcytosis in dog ...
In this paper we present a chemometric method of analysis leading to isolation of Fourier transform infrared (FT-IR) spectra of biomacromolecules (HEW lysozyme, ctDNA) affected by osmolytes (trimethylamine-,i,N,/i,-oxide and ,i,N,N,N,/i,-trimethylglycine, respectively) in aqueous solutions. The method is based on the difference spectra method primarily used to characterize the structure of solvent affected by solute. The cyclical usage of factor analysis allows precise information to be obtained on the shape of affected spectra of analyzed biomacromolecules. Affected spectra of selected biomacromolecules give valuable information on their structure in the presence of the osmolytes in solution, as well as on the level of perturbation in dependence of osmolyte concentration. The method also gives a possibility of insight into the mechanism of interaction in presented types of systems. It can be easily adapted to various chemical and biochemical problems where vibrational or ultraviolet-visible ...
NMDA receptors are hetero-oligomers assembled from two typesof subunits, NR1 and NR2. The NR1 subunit is a single geneproduct, whereas the NR2 subunit is encoded by four differentgenes: NR2A-NR2D (147). Native NMDA receptors are thoughtto be heteromultimers containing four or five subunits consistingof two NR1 subunits and two or three NR2 subunits (38). Atmost synapses throughout the central nervous system, NMDA receptorsare composed of NR1 subunits in combination with either NR2Aor NR2B subunits. NR2A and NR2B subunits are ubiquitously distributedthrough the central nervous system and have been shown to undergoa developmental switch in hippocampal and cortical neurons(179). At birth NMDA receptors are composed of NR1/NR2B subunits,and there is a switch from NR2B to NR2A subunits around P7.However, in the LA, a recent study has shown that applicationof the NR2B-selective antagonist ifenprodil blocks the inductionof fear conditioning, suggesting that receptors containingNR2B subunits are present ...
Conformational flexibility is intrinsically related to the functionality of biomolecules. Elucidation of the potential energy surface is thus a necessary step towards understanding the mechanisms for molecular recognition such as docking of small organic molecules to larger macromolecular systems. In this wo
Most biological macromolecules are homochiral, and enzymes help to maintain this state of affairs; for example, checkpoints ensure that only l-amino acids are incorporated into proteins during translation. Among these enzymes is d-aminoacyl-tRNA deacylase (DTD), which removes d-amino acids mischarged onto tRNAs. Three types of DTDs have been identified, with the most common form being present in many bacteria and all eukaryotes. DTD faces the mechanistic challenge of acting on diverse d-aminoacyl-tRNAs (d-aa-tRNAs) while not harming l-aminoacyl-tRNAs (l-aa-tRNAs) that are present at much higher concentrations. Although crystal structures have been determined for DTD in the apo form and bound to free d-amino acids, the structural basis of enantioselectivity remained unclear. Ahmad et al. report the crystal structure of dimeric DTD from Plasmodium falciparum in complex with a substrate analog that mimics d-tyrosine attached to the 3′-OH of the terminal adenosine of tRNA. A critical role in ...
Top research professionals in the field of vascular ion channels were personally recruited by Drs. Dopico and Levitan to participate and contribute to chapters in the book. This will allow the book to be used as a reference tool for not only research specialists, but also PhD candidates. Among those recruited were Jonathan Jaggar, PhD, and Maury Bronstein Professor in the Department of Physiology at UTHSC.. Each chapter is written by an internationally recognized expert in the field based on his own work, said Dr. Dopico. The key goal for us was not for each researcher to just write a chapter summarizing other peoples work, but to write about the novel research they are actually doing and frame within the wider context of vascular physiology and pathology.. The book is able to cover how ion channels transmit signals throughout vascular systems in normal human function or disease, and how these macromolecules may serve as therapeutic targets. Macromolecules are large molecules such as ...
Animal Cell The nucleus is a large organelle that is normally 5 micrometers in length and contains most of the genetic material of a cell. Centrosome A digestive organelle where macromolecules are hydrolyzed Lysosome Organelle active in synthesis, modification, sorting and secretion of cell products This is the membrane enclosing the cell, it is made of a bilayer of phospolipids that only allow some things into the cell This is a chromosome. Chromosomes are long strands of DNA that stay in pairs. The average cell contains 23 pairs of chromosomes. Chromosomes also determine the sex of a person. This is the Nuclear Envelope ...
The interaction of small molecules with protein targets is an area in which NMR spectroscopy can play a key role, providing information on the behavior of the small molecule and on structural changes in the protein itself. A wide range of techniques are available to probe such interactions (such as saturation transfer difference and WaterLOGSY) and we are interested in further developing and applying such methods to a variety biological systems. We also employ protein-observe methods when isotopically labelled macromolecules are available. We apply these methods to 2-oxoglutarate dependent Fe(II) enzymes, in collaboration with Prof. Chris Schofield. ...
With the slowdown in world economic growth, the Analytical Ultracentrifuge System industry has also suffered a certain impact, but still maintained a relatively optimistic growth, the past four years,...
Avidin and streptavidin reagents are powerful tools to detect or purify biotinylated proteins, nucleic acids, and other macromolecules.
This course will provide a high-level overview on the structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics include protein and nucleic acid folding, energetic of macromolecular interactions (kinetics and thermodynamics), and mechanistic enzymology. Using specific examples from the current literature, each topic will stress how chemists have used molecular level tools and probes to help understand the specific systems under study. The over arching theme in this course will be the structure and function and intimately linked.. ...
Bober, P., Liu, J., Mikkonen, K. S., Ihalainen, P., Markus, P., Plumed-Ferrer, C., von Wright, A., Lindfors, T., Xu, C. & Latonen, R-M., 2014, I : Biomacromolecules. 15, 10, s. 3655-3663 9 s.. Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review ...
A team of Monash researchers have determined the 3D-structure of a SARS-CoV-2 protein at atomic resolution using the macromolecular crystallography beamlines Australian Synchrotron.
This unit should take you approximately 24 hours to complete. ☐ Subunit 3.1: 1.0 hour ☐ Subunit 3.2: 2.5 hours ☐ Subunit 3.3: 2.0 hours ☐ Subunit 3.4: 5.0 hours ☐ Subunit 3.4.1: 1.0 hour ☐ Subunit 3.4.2: 1.0 hour ☐ Subunit 3.4.3: 0.5 hour ☐ Subunit 3.4.4: 0.5 hour ☐ Subunit 3.4.5: 1.0 hour ☐ Subunit 3.4.6: 1.0 hour. ☐ Subunit 3.5: 3.0hours ☐ Subunit 3.6: 2.5 hours ☐ Subunit 3.7: 2.0 hours ☐ Subunit 3.8: 2.0 hours ☐ Subunit 3.9: 4.0 hours ☐ Subunit 3.9.1: 1.0 hour ☐ Subunit 3.9.2: 1.0 hour ☐ Subunit 3.9.3: 1.0 hour ☐ Subunit 3.9.4: 1.0 hour. Unit3 Learning Outcomes ...
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Introduction- The vast complexity of a single organism, including humans, is attributed to the intricacies found within their bio molecular contents. These
A second tail allows deflection of the highly resolved monochromatic beam to a second, user-selected or provided, endstation ...
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Free AP Biology flashcards - Biochemical Concepts - Macromolecules. Work through hundreds of free flashcards and see your grades and test scores improve.
টক্সিন ( প্রাচীন গ্রিক: শব্দτοξικόν toxikon(টক্সিকন) থেকে এর উৎপত্তি) হচ্ছে এক প্রকার বিষাক্ত পদার্থ যা উৎপন্ন হয় জীব বা জীবকোষের অভ্যন্তরে।[১][২] টক্সিকেন্ট কৃত্রিমভাবে জীবকোষের বাইরে প্রস্তুত করা যায়। এই কাজটি প্রথম করেন জৈব রসায়নবিদ লুডউইক ব্রেইজের।(১৮৪৯-১৯১৯)[৩] টক্সিন হতে পারে small molecule, পেপটাইড অথবা প্রোটিন। এগুলো রোগ তৈরী করতে, শরীরের টিস্যুকে ধ্বংস করে দিতে সক্ষম। জৈব macromolecule ...
... and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites ... "Catalysis of the transfer of a specific substance or related group of substances from one side of the membrane to the other." " ... Isomerase is the systematic name for any enzyme of EC class 5." "Catalysis of the ligation of two substances with concomitant ... Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is ...
... s are carbon-based macromolecular substances, that can be found in soil chemistry or as a by-product from saccharide-based ... Humic substances, including humin, have not been observed in soils using modern analytical techniques. Humins also produced ... 2010-02-01). "Humin-like substances formed under the conditions of industrial hydrolysis of wood". Russian Journal of Applied ... Humins are not considered to be a dangerous substance according to officially recognized hazardous material classification ...
... absorbs macromolecular toxic substances by a mechanism of precipitation in the gel (e.g., bacterial toxins); exhibits ... PMSPH absorbs toxic substances from the gastrointestinal tract as well as toxic substances (xenobiotics) trapped in the gastro- ... It acts as sorbent for binding toxic substances of various natures, pathogens and metabolites in the gastrointestinal tract and ... matrix determines absorptive capacity of the mechanism of molecular adsorption and allows mostly to adsorb toxic substances and ...
Such covalent substances are usually gases, for example, HCl, SO2, CO2, and CH4. In molecular structures, there are weak forces ... Macromolecular structures have large numbers of atoms linked by covalent bonds in chains, including synthetic polymers such as ... Such covalent substances are low-boiling-temperature liquids (such as ethanol), and low-melting-temperature solids (such as ... There are several types of structures for covalent substances, including individual molecules, molecular structures, ...
... conducted extensive research of the regularities of the dynamics of low-molecular weight additives in macromolecular substances ... Kovarski new methods for the research of magnetic nanoparticles aggregation in dispersions and macromolecular adsorption on ...
... macromolecular substances D06 - hormones, hormone substitutes, and hormone antagonists D07 - none (enzymes and coenzymes) D08 ...
The statutes of the GFP set out the following goals: the advancement and dissemination of studies on macromolecular substances ...
... based on a highly specific macromolecular binding interaction between the biomolecule and another substance. The specific type ... Carbohydrate bonding is most often used with glycoproteins or any other carbohydrate-containing substance; carbohydrate is used ...
The Differentiation and Specificity of Corresponding Proteins and other Vital Substances in Relation to Biological ... It contained beta sheet (antiparallel) as well as helices, and was also the first macromolecular structure to have its atomic ... "Biophysical highlights from 54 years of macromolecular crystallography". Biophysical Journal. 106 (3): 510-525. doi:10.1016/j. ...
Substance composed of macromolecules. Note: Applicable to substance macromolecular in nature like cross-linked. systems that ...
Generally, both are substances that are capable of generating antibodies (antigen) or stimulating immune responses (immunogen ... We can define an immunogen as a complete antigen which is composed of the macromolecular carrier and epitopes (determinants) ... An immunogen is an antigen or any substance that may be specifically bound by components of the immune system (antibody, ... An adjuvant (from Latin adiuvare - to help) is any substance, distinct from antigen, which enhances immune response by various ...
In: Journal of Macromolecular Science: Part A - Chemistry. 16, 2006, p. 1463-1472, doi:10.1080/00222338108063248. Theodor Weyl ... the 26th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances ... the 26th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances ...
... unique small molecule chemical structures PubChem Substance: deposited chemical substance records Genome Project: genome ... three-dimensional macromolecular structures Taxonomy: organisms in GenBank Taxonomy dbSNP: single nucleotide polymorphism Gene ... bioactivity screens of chemical substances Probe: sequence-specific reagents NLM Catalog: NLM bibliographic data for over 1.2 ...
... "for her determinations by X-ray techniques of the structures of important biochemical substances." The substances included ... 233, 223 (1971) Meyer, E. F. Jr (1971). Interactive computer display for the three-dimensional study of macromolecular ... à plusieurs genres de substances cristallisées, Chez Gogué et Née de La Rochelle, Paris Haüy, R.J. (1795). Leçons de Physique, ... angles are constant and characteristic for crystals of the same chemical substance. 1784 - René Just Haüy publishes his Law of ...
2010). "Hydrophobic substances induce water stress in microbial cells". Microbial Biotechnology. 3 (6): 701-716. doi:10.1111/j. ... even though they partition into the hydrophobic domains of macromolecular systems. Hamaguchi & Geiduschek (1962). "The Effect ... According to the original usage and work carried out on cellular stress mechanisms and responses, chaotropic substances do not ... Furthermore, hydrophobic substances known to stress cellular systems (including benzene and toluene) can chaotropically ...
Embedded within this membrane is a macromolecular structure called the porosome the universal secretory portal in cells and a ... in that it can either let a substance (molecule or ion) pass through freely, pass through to a limited extent or not pass ...
PubChem Substance: deposited chemical substance records. *Genome Project: genome project information. *UniGene: gene-oriented ... Structure: three-dimensional macromolecular structures. *Taxonomy: organisms in GenBank Taxonomy. *dbSNP: single nucleotide ...
Extracellular polymeric substance Microneme Mucilage Strom, M S; Lory, S (1993-10-01). "Structure-Function and Biogenesis of ... Energized nano-machinery or large macromolecular assemblies located on the bacterium's cell body. "Focal adhesion complexes" ...
"for his investigations into the disintegration of the elements, and the chemistry of radioactive substances". ... "for his discoveries in the field of macromolecular chemistry". *^ "The Nobel Prize in Chemistry 1954". Nobelprize.org. http:// ... "for his contributions to our knowledge of the chemistry of radioactive substances, and his investigations into the origin and ... "for his investigations of the constitution of the bile acids and related substances". ...
His work in macromolecular synthesis underlies the development of "smart" materials, which respond to external cues like ... Recognizing that most synthetic polymers are mixtures, rather than pure substances, he developed pioneering techniques for the ... Implications for macromolecular design, evolution and analysis". In Zewail, Ahmed H. (ed.). Physical Biology: From Atoms to ...
"Unusual Names Assigned to Chemical Substances" presented at the 101-st National Meeting of the ACS on April 14, 1986, and ... as member of the Commission on Macromolecular Nomenclature (1987-1999). Metanomski participated in the IUPAC as secretary of ...
Macromolecular structure and function is dependent on the net effect of these forces (see protein folding), therefore it ... A chaotropic agent is a substance which disrupts the structure of, and denatures, macromolecules such as proteins and nucleic ... Antichaotropic salts such as ammonium sulphate can be used to precipitate substances from the impure mixture. This is used in ... "Hydrophobic substances induce water stress in microbial cells". Microbial Biotechnology. 3 (6): 701-716. doi:10.1111/j.1751- ...
The cytosol is a complex mixture of substances dissolved in water. Although water forms the large majority of the cytosol, its ... This high concentration of macromolecules in cytosol causes an effect called macromolecular crowding, which is when the ... Hoppert M, Mayer F (1999). "Principles of macromolecular organization and cell function in bacteria and archaea". Cell Biochem ... The cytosol also contains large amounts of macromolecules, which can alter how molecules behave, through macromolecular ...
Examples of such substances are xanthan and guar gum. Destabilization can be accomplished by different methods: Removal of the ... Commission on Macromolecular Nomenclature. Cambridge: Royal Society of Chemistry. ISBN 978-1-84755-942-5. OCLC 406528399. ... If this is the case, then the colloidal particles will repel or only weakly attract each other, and the substance will remain a ... From page 183: "As gelatine appears to be its type, it is proposed to designate substances of the class as colloids, and to ...
Molecular and Cellular Biotechnology Chemistry and Technology of biologically active substances Technology of drugs Technology ... of organometallic compounds Chemical technology of natural energy and carbon materials Chemical Technology of Macromolecular ... and biological synthesis of various types of lipids and their complexes with a variety of biologically active substances, the ...
MeSH D05 --- macromolecular substances. *MeSH D06 --- hormones, hormone substitutes, and hormone antagonists ...
Linus Pauling and J. H. Sturdivant (1937): "The Structure of Cyameluric Acid, Hydromelonic Acid and Related Substances". ... Tamikuni Komatsu (2001): "The First Synthesis and Characterization of Cyameluric High Polymers". Macromolecular Chemistry and ...
We call homologous substances those that have the same chemical properties and whose composition offers certain analogies in ... ISBN 978-0-13-126202-7. OCLC 21973767.CS1 maint: numeric names: authors list (link) Saarela, K. (2013-10-22). Macromolecular ... Nous appelons substances homologues celles qui jouissent des même propriétés chimiques et dont la composition offre certaines ... ISBN 978-1-4832-8025-7. Charles Gerhardt (1843) "Sur la classification chimique des substances organiques" (On the chemical ...
Alternatively, the fibers, along with other extracted substances, can be processed chemically or digested to produce ethanol ... Characterization and properties". Die Angewandte makromolekulare Chemie: Applied macromolecular chemistry and physics. Hüthig ... and other useful substances. Maurizio Avella; Claudio Bozzi; Ramiro dell'Erba; Bonaventura Focher; Annamaria Marzetti; Ezio ...
Macromolecular components of respiratory secretions (proteins, glycoproteins, lipids, nucleic acids) are converted to nutrients ... Secondly, they are able to produce antibacterial substances called bacteriocins which inhibit the growth of pathogens. Genera ...
Ground substance slows the spread of pathogens.. *Fibers. Not all types of CT are fibrous. Examples of non-fibrous CT include ... Mathews, M. B. (1975). Connective Tissue, Macromolecular Structure Evolution. Springer-Verlag, Berlin and New York. link. ... Ground substance - A clear, colorless, and viscous fluid containing glycosaminoglycans and proteoglycans to fix the body water ... All connective tissue consists of three main components: fibers (elastic and collagenous fibers),[1] ground substance and cells ...
response to toxic substance. • DNA repair. • response to X-ray. • response to drug. • DNA unwinding involved in DNA replication ... macromolecular complex. Biological process. • regulation of protein phosphorylation. • strand invasion. • mitotic recombination ...
... essentially the macromolecular synthesis of cell proteins is shut off. Over the next 1-2 hours there is a loss of margination ... around 2500 nm in length so we can therefore conclude that it must be tightly packaged within the capsid along with substances ...
macromolecular complex binding. Cellular component. • cytoplasm. • cytosol. • cyclin-dependent protein kinase holoenzyme ... response to toxic substance. • positive regulation of cell cycle. • signal transduction. • multicellular organism development. ... macromolecular complex. Biological process. • phosphorylation. • response to testosterone. • positive regulation of fibroblast ... response to organic substance. • cellular response to insulin stimulus. • regulation of multicellular organism growth. • ...
"for his discoveries in the field of macromolecular chemistry"[45] 1954 لینس پالنگ امریکا "for his research into the nature of ... "for his investigations into the disintegration of the elements, and the chemistry of radioactive substances"[8] ... "for his contributions to our knowledge of the chemistry of radioactive substances, and his investigations into the origin and ... "for her determinations by X-ray techniques of the structures of important biochemical substances"[56] ...
Such secretagogue peptides have been on the WADA prohibited substances list since at least 2008. The Australian Crime ... or to complex macromolecular assemblies.[3] Finally, while aspects of the lab techniques applied to peptides versus ... prohibited substances on the World Anti-Doping Agency (WADA) Prohibited List, and are therefore prohibited for use by ...
Antibodies are protein components of an adaptive immune system whose main function is to bind antigens, or foreign substances ... cryo-electron microscopy of large macromolecular assemblies[97] and computational protein structure prediction of small protein ... "Sur la composition de quelques substances animales". Bulletin des Sciences Physiques et Naturelles en Néerlande: 104. ... "Green fluorescent protein as a reporter for macromolecular localization in bacterial cells". Methods. 20 (1): 62-72. doi ...
"for his discoveries in the field of macromolecular chemistry"[52] 1954 Linus Carl Pauling United States "for his research into ... "for his investigations into the disintegration of the elements, and the chemistry of radioactive substances"[15] ... "for his contributions to our knowledge of the chemistry of radioactive substances, and his investigations into the origin and ... "for her determinations by X-ray techniques of the structures of important biochemical substances"[63] ...
Ye, Yanqi; Yu, Jicheng; Gu, Zhen (2015). "Versatile Protein Nanogels Prepared by In Situ Polymerization". Macromolecular ... situ baking refers to heating parts of the vacuum system while they are under vacuum in order to drive off volatile substances ...
response to toxic substance. • response to UV. • response to X-ray. • response to drug. • negative regulation of cell ... macromolecular complex binding. Cellular component. • cytoplasm. • cytosol. • cyclin-dependent protein kinase holoenzyme ... response to organic substance. • negative regulation of gene expression. • cellular response to DNA damage stimulus. • negative ... macromolecular complex. Biological process. • cellular response to extracellular stimulus. • signal transduction by p53 class ...
... is the movement of material from one point to another, e.g. secreted chemical substance from a cell or gland. In ... which shows the versatility of this macromolecular secretion apparatus.[14] ... contrast, excretion, is the removal of certain substances or waste products from a cell or organism. The classical mechanism of ...
Houwink, AL (1953). "A macromolecular mono-layer in the cell wall of Spirillum spec". Biochim Biophys Acta. 10 (3): 360-6. doi: ... barrier against high-molecular-weight substances (e.g., lytic enzymes). *adhesion (for glycosylated S-layers) ... Since the first evidence of a macromolecular array on a bacterial cell wall fragment in the 1950s[15] S-layer structure has ...
"Macromolecular chemistry" redirects here. For the journal formerly known as Macromolecular Chemistry, see Macromolecular ... which suggests a substance composed of macromolecules.[8] ... as either macromolecular or polymeric, or by polymer used ... The article is based on the book, Inventing Polymer Science: Staudinger, Carothers, and the Emergence of Macromolecular ... Another common macromolecular property that does not characterize smaller molecules is their relative insolubility in water and ...
Since 2019, a mole of any substance has been redefined in the SI as the amount of that substance containing an exactly defined ... cite journal , title = International union of pure and applied chemistry, commission on macromolecular nomenclature, note on ... The molar mass is appropriate for converting between the mass of a substance and the amount of a substance for bulk quantities ... In chemistry, the molar mass is defined as the mass of a sample of that compound divided by the amount of substance in that ...
Hanson BL, Harp JM, Bunick GJ (2003). "The well-tempered protein crystal: annealing macromolecular crystals". Macromolecular ... "For her determinations by X-ray techniques of the structures of important biochemical substances"[151] ... Jeruzalmi D (2006). "First analysis of macromolecular crystals: biochemistry and x-ray diffraction". Macromolecular ... 1997). Macromolecular Crystallography, Part A (Methods in Enzymology, v. 276). San Diego: Academic Press. ISBN 0-12-182177-3. . ...
macromolecular complex. Biological process. • positive regulation of cyclic nucleotide-gated ion channel activity. • ... ATPase activity, coupled to transmembrane movement of substances. • intracellular ATPase-gated chloride channel activity. • ...
Braconnot HM (1820). "Sur la conversion des matières animales en nouvelles substances par le moyen de l'acide sulfurique". Ann ... Sanda, Fumio; Endo, Takeshi (1999). "Feature Article Syntheses and functions of polymers based on amino acids". Macromolecular ... "Journal of Macromolecular Science, Part A 42 (9): 1299-1315. doi:10.1080/10601320500189604 . http://www.informaworld.com/index/ ...
Macromolecular Chemistry and Physics. 196 (1): 353-67. doi:10.1002/macp.1995.021960125.. ...
Any material develops a dielectric polarization when an electric field is applied, but a substance that has such a natural ... and List of biophysically important macromolecular crystal structures. ... the number of d-orbitals in bond formation with the bond length as well as many of the physical properties of the substance. He ...
A chemical substance produced by a living organism; - a term used commonly in reference to chemical substances found in nature ... often have very specific interactions with a macromolecular target in the body (e.g. α-bungarotoxin from cobras). As with plant ... Whereas the synthesis of inorganic substances had been known for a long time, the synthesis of organic substances was a ... of the substance of interest, where the focus is on identification and quantitation of the substance (e.g. in biological tissue ...
Embedded within this membrane is a macromolecular structure called the porosome the universal secretory portal in cells and a ... in that it can either let a substance (molecule or ion) pass through freely, pass through to a limited extent or not pass ...
response to organic substance. • anterograde axonal transport. • cell aging. • spermatogenesis. • response to ethanol. • ... macromolecular complex. Biological process. • negative regulation of neuron apoptotic process. • muscle cell cellular ...
... buds have been listed as one of the 38 substances used to prepare Bach flower remedies,[98] a kind of alternative ... Pasch, H. (2002). "Considerations on the macromolecular structure of chestnut ellagitannins by matrix-assisted laser desorption ...
If two substances had empirical formulae that were integer multiples of each other - e.g., acetylene (C2H2) and benzene (C6H6 ... Polymers are studied in the fields of biophysics and macromolecular science, and polymer science (which includes polymer ... A polymer is a substance composed of macromolecules.[2] A macromolecule is a molecule of high relative molecular mass, the ... There are multiple conventions for naming polymer substances. Many commonly used polymers, such as those found in consumer ...
SUR LA COMPOSITION DE QUELQUES SUBSTANCES ANIMALES. *^ Hartley Harold (1951). "Origin of the Word 'Protein.'". Nature. 168 ( ... cryo-electron microscopy of large macromolecular assemblies[91] and computational protein structure prediction of small protein ... Antibodies are protein components of an adaptive immune system whose main function is to bind antigens, or foreign substances ... "Green fluorescent protein as a reporter for macromolecular localization in bacterial cells". Methods (San Diego, Calif.). 20 ...
Antibodies are protein components of an adaptive immune system whose main function is to bind antigens, or foreign substances ... Margolin W (January 2000). "Green fluorescent protein as a reporter for macromolecular localization in bacterial cells". ... cryo-electron microscopy of large macromolecular assemblies[97] and computational protein structure prediction of small protein ... "Sur la composition de quelques substances animales". Bulletin des Sciences Physiques et Naturelles en Néerlande: 104. ...
"for his discoveries in the field of macromolecular chemistry". ১৯৫৪. লিনাস পাউলিং. যুক্তরাষ্ট্র. "for his research into the ... "for her determinations by X-ray techniques of the structures of important biochemical substances". ...
macromolecular complex. Biological process. • negative regulation of signal transduction by p53 class mediator. • endocardial ... response to toxic substance. • response to morphine. • atrioventricular valve morphogenesis. • protein localization to nucleus ... cellular response to organic substance. • cellular response to hydrogen peroxide. • response to cocaine. • cardiac septum ...
Biocides; (macromolecular substances as carriers for biocide material A01N 25/10)} [2013-01] ... Biocides (macromolecular substances as carriers for biocide material A01N 25/10) [2018-01] ... Ingredients treated with organic substances {(treated with macromolecular compounds C08K 9/08)} [2013-01] ... Use of inorganic or non-macromolecular organic substances as compounding ingredients (paints, inks, varnishes, dyes, polishes, ...
ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.. About ASM , Contact Us , Press Room. ASM is a member of. ...
Most biological reactions rely on interplay between binding and changes in both macromolecular structure and dynamics. ...
The invention relates to flame retardant combinations containing - phosphinic acid salt of the formula (I) as component A, wherein R1 and R2 represent ethyl, M represents Al, Fe, TiOp or Zn, m is 2 to 3, and p = (4 - m) /2, a compound se ...
The interrelationship among histamine, various vasoactive substances, and macromolecular permeability in the canine forelimb.. ... The interrelationship among histamine, various vasoactive substances, and macromolecular permeability in the canine forelimb. ... The interrelationship among histamine, various vasoactive substances, and macromolecular permeability in the canine forelimb. ... The interrelationship among histamine, various vasoactive substances, and macromolecular permeability in the canine forelimb. ...
Macromolecular Substances. Accession Number. DBCAT000809. Description. Compounds and molecular complexes that consist of very ... In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ... It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material,.... ... Carbomer homopolymer type C is a high molecular polyanionic substance tested for antiulcerogenic activity. ...
"Macromolecular Substances" by people in this website by year, and whether "Macromolecular Substances" was a major or minor ... "Macromolecular Substances" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ... Below are the most recent publications written about "Macromolecular Substances" by people in Profiles. ...
define Macromolecular Substances. Explain Macromolecular Substances. What is Macromolecular Substances? Macromolecular ... Macromolecular Substances. Medical Dictionary -> Macromolecular Substances. Search: Macromolecular Substances. Compounds and ... In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ...
Quantitative tumor microvascular permeability assays generated with macromolecular MR imaging contrast medium correlate closely ... Macromolecular Substances * Magnetic Resonance Imaging / methods* * Mammary Neoplasms, Experimental / chemically induced * ... Results: Tumor permeability to macromolecular contrast medium, characterized by K(PS), showed a highly positive correlation ... Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small- ...
617-0929/01 - Thermal Degradation of Macromolecular Substances (PTDML) Gurantor department. Department of Chemistry. Credits. ... Understanding the theoretical fundaments of macromolecular chemistry with a focus on the theory of degradation and pyrolysis. ...
617-0929/02 - Thermal Degradation of Macromolecular Substances (PTDML) Gurantor department. Department of Chemistry. Credits. ... Understanding the theoretical fundaments of macromolecular chemistry with a focus on the theory of degradation and pyrolysis. ... Physical and chemical parameters affecting the distribution of substances in environmental media. 3.Chemical bonding and ...
Biopolymers are polymers synthesized by living organisms that play a role in the formation of macromolecular structures and are ... In protein science, Polypeptides, as biopolymeric substances, are peptides composed of a single linear chain of approximately ... In our bodys cells, Polynucleotides (Nucleic Acids) are biopolymeric substances of deoxyribonucleic acid (dna) and ribonucleic ... In protein science, Collagen, a polypeptide substance, with a unique configuration of a triple helical structure, in which ...
Results of search for su:{Macromolecular Substances.} Refine your search. *Availability * Limit to currently available items. ...
Macromolecular Substances. Molecular Weight. Mollusca / analysis*. Mucins. Protein Conformation. Sialic Acids. ... 0/Amino Acids; 0/Carbohydrates; 0/Lectins; 0/Macromolecular Substances; 0/Mucins; 0/Sialic Acids ...
Increasingly powerful methods of analysis have opened up complex macromolecular assemblies to scrutiny at atomic detail. They ... Macromolecular Substances. Microscopy, Electron. Models, Molecular. Nucleic Acid Conformation. Protein Conformation. Ribosomes ... Next Document: Macromolecular crowding: an important but neglected aspect of the intracellular environment.. ... Increasingly powerful methods of analysis have opened up complex macromolecular assemblies to scrutiny at atomic detail. They ...
Any reaction that depends on the available volume can be affected by macromolecular crowding, but the effects of crowding in ... Macromolecular Substances / metabolism* * Microscopy, Confocal * Microscopy, Fluorescence * Molecular Dynamics Simulation * ... Design and Properties of Genetically Encoded Probes for Sensing Macromolecular Crowding Biophys J. 2017 May 9;112(9):1929-1939. ... Any reaction that depends on the available volume can be affected by macromolecular crowding, but the effects of crowding in ...
Clarke, R. M., & Hardy, R. N. (1969). An analysis of the mechanism of cessation of uptake of macro‐molecular substances by the ... Clarke, Rufus M. ; Hardy, R. N. / An analysis of the mechanism of cessation of uptake of macro‐molecular substances by the ... An analysis of the mechanism of cessation of uptake of macro‐molecular substances by the intestine of the young rat (closure) ... An analysis of the mechanism of cessation of uptake of macro‐molecular substances by the intestine of the young rat (closure) ...
Substance. *Macromolecular Substances. LinkOut - more resources. Full Text Sources. *Public Library of Science ... Given the limited accuracy of force fields, macromolecular simulations sometimes produce results that are at not in complete ... Publication types, MeSH terms, Substance. Publication types. *Research Support, Non-U.S. Govt ...
Substance. *Macromolecular Substances. Grant support. *KL2 TR000428/TR/NCATS NIH HHS/United States ... The diffusion of any substance within the CNS may be affected by a number of properties associated with the brain ... Regardless of whether a drug or other substance crosses the blood-brain barrier or is directly applied within the brain, ... While the range of substances that may be explored using the ventriculo-cisternal perfusion method is broad, the complexity of ...
Modification of Macromolecular Substances Pages 329-379 * Back Matter Pages 381-385 ... manual Labormanual Materials Science Polymer chemistry Polymer theory Polymerchemie Polymertheorie experiments macromolecular ...
Modification of Macromolecular Substances. Pages 323-373. Braun, Dietrich (et al.). Preview Buy Chapter £19.95 ... Matthias Rehahn holds a professorship at the Ernst-Berl-Institute for Technical and Macromolecular Chemistry at the Technical ... h. c. Helmut Ritter is head of the Institute of Organic Chemistry and Macromolecular Chemistry at the University Düsseldorf. ... and head of the IPF Institute Macromolecular Chemistry. ...
Inducing macromolecular interactions with small substances to trigger cellular signaling is. Posted on December 10, 2018. by ... Inducing macromolecular interactions with small substances to trigger cellular signaling is definitely a challenging objective ... 9). We following tested the experience of the brand new structure-designed substances to stimulate degradation of Wager ...
Macromolecular Substances • Homosexuality • Immunity • Life Style • Tomography, X-Ray Computed • Herpes Zoster • Regional Blood ...
Anthraquinone derivatives for pigmenting organic macromolecular substances. US4286957. Jan 10, 1979. Sep 1, 1981. Essilor ... Process of integrating a photochromic substance into an ophthalmic lens and a photochromic lens of organic material. ... Test Report, Japan Food Research Laboratories, "Qualitative test of fluorescent substances", Mar. 13, 1996, No. 49022440, 2 ...
Polarographic analysis of cholesterol and other macromolecular substances. US4053381 *. 19 May 1976. 11 Oct 1977. Eastman Kodak ... The term "mediator" is defined as a substance that may be oxidized or reduced and that may transfer one or more electrons. A ... The use of the term "on" does not exclude the presence of substances between the upper and lower elements being described. For ... The term "analyte" is defined as one or more substances present in a sample. The analysis determines the presence and/or ...
Process and compounds for surface modification of macromolecular substances. US4752426 *. Jun 27, 1986. Jun 21, 1988. Yoshito ... a substance which inhibits platelet aggregation will hereinafter be referred to as antithrombotic and a substance which ... II above and R is a substance which inhibits the thrombotic or clotting activity of the material and is that portion of a ... Once the diazonium salt is formed, it can be coupled with a substance which possesses antithrombotic or anticlotting activity ...
5. Macromolecular substances. D) The principles of materials corrosion. Recommended or Required Reading. ...
Modes of Absorption of Macromolecular Substances G. Gebert. Pages 23-28 * The Quantitative Absorption of Orally Administered ...
1990) The clearance of macromolecular substances such as cartilage markers from synovial fluid and serum. in Methods in ... Macromolecular removal from joints is chiefly by drainage of the fluid across the synovial lining into the subsynovial ... Curve B shows the effect of doubling the macromolecular input rate, or of halving the fluid turnover rate. Curve C shows the ... It is found that, when the intra-articular half lives of albumin and a macromolecular test solute are determined simultaneously ...
... oligomers and natural or synthetic macromolecular substances as well as their mixtures, if the monomers or starting substances ... Other substances or matter may be added to such macromolecular compounds.. However, the following shall not be regarded as ... natural or synthetic macromolecular substances used in the manufacture of modified macromolecules, if the monomers or the other ... by including new substances, i.e. substances which are listed neither in Section A nor in Section B of Annex II, according to ...
  • The group includes compounds with relatively small molecules, such as the simple sugars (monosaccharides, disaccharides, etc.), as well as macromolecular (polymeric) substances such as starch, glycogen, and cellulose. (thefreedictionary.com)
  • Substances studied by chemists range from the commonplace such as air and water to unique compounds produced in research laboratories. (edu.au)
  • Most of the chemical substances have unique features that allows sorting them to ionic, molecular, macromolecular and metallic compounds. (ipl.org)
  • Understanding the theoretical fundaments of macromolecular chemistry with a focus on the theory of degradation and pyrolysis. (vsb.cz)
  • Since 1999 Prof. Dr. Matthias Rehahn holds a professorship at the Ernst-Berl-Institute for Technical and Macromolecular Chemistry at the Technical University Darmstadt, and he is the leader of the German Institute for Synthetic Materials in Darmstadt. (springer.com)
  • Helmut Ritter is head of the Institute of Organic Chemistry and Macromolecular Chemistry at the University Düsseldorf. (springer.com)
  • Prof. Dr. Brigitte Voit is Managing Director/Chief Scientific Officer (CSO) of the "Leibniz-Institut für Polymerforschung Dresden e.V." (IPF) and head of the IPF Institute Macromolecular Chemistry. (springer.com)
  • Chemistry is concerned with the structure, properties and reactions of substances at the atomic, molecular and macromolecular scale. (edu.au)
  • These substances are among the most versatile and efficient building blocks of macromolecular chemistry. (industrysourcing.com)
  • This contribution will provide a brief overview of our past and ongoing work in this new field of environmental (bio-) macromolecular chemistry. (ufz.de)
  • DESCRIPTION (provided by applicant): The objective of the proposed research is to determine structures of reaction intermediates in two separate metalloenzyme systems that operate within macromolecular complexes. (elsevier.com)
  • PUBLIC HEALTH RELEVANCE: The proposed work, determining X-ray crystal structures of reaction intermediates in two distinct prokaryotic enzymes that operate within macromolecular complexes, is motivated by the information it will provide about the mechanistic details of the reactions catalyzed, both of which are completely novel. (elsevier.com)
  • Woodson, Sarah A. / Macromolecular complexes : How RNA and protein get together . (elsevier.com)
  • this term includes gene products that are parts of macromolecular complexes, by the definition that all members of a complex normally copurify under all except extreme conditions. (wikipedia.org)
  • Transmission electron microscopy is a powerful tool that is used to explore the internal structure of tissues, cells, organelles and macromolecular complexes. (elsevier.com)
  • For example, (1) a comparison of macromolecular reflection by rheumatoid compared with healthy human synovium would increase our understanding of the pathophysiology of synovial effusions, would quantify the changes in the state of the synovial lining brought about by the disease, and also allow quantification of synovial responses to drug treatment. (bmj.com)
  • Dynamic contrast-enhanced MR imaging was performed using a small-molecular contrast medium (gadopentetate, molecular weight = 0.5 kDa) and a macromolecular contrast medium (albumin-(Gd-DTPA)30, molecular weight = 92 kDa) at an interval of 1-2 days. (nih.gov)
  • It is found that, when the intra-articular half lives of albumin and a macromolecular test solute are determined simultaneously, the reflected fraction of the test solute is given by the complement of the half life ratio. (bmj.com)
  • Lastly, we present several known molecular modifications in the albumin molecule itself, as well as substances bound to it, which may be important and potentially clinically relevant mediators of albumin-induced glomerular injury. (deepdyve.com)
  • Macromolecular Substances" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rtrn.net)
  • In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure. (drugbank.com)
  • Compound that includes simple sugars and macromolecular (polymeric) substances (e.g., starch, glycogen). (thefreedictionary.com)
  • The experimental, methodological and conceptual challenges of working with macromolecular ('polymeric') organic substances in water and soil systems will be highlighted by two illustrative examples. (ufz.de)
  • The interrelationship among histamine, various vasoactive substances, and macromolecular permeability in the canine forelimb. (ahajournals.org)
  • Quantitative tumor microvascular permeability assays generated with macromolecular MR imaging contrast medium correlate closely with histologic tumor grade. (nih.gov)
  • We following tested the experience of the brand new structure-designed substances to stimulate degradation of Wager proteins in cells, ABT-751 and noticed impressive Brd4-selective depletion whatsoever concentrations examined, with depletion of Brd4 after 24 h treatment with 1C3 M of AT1 and negligible activity against Brd2 and Brd3 (Fig. 4e, observe Supplementary Fig. 9 for AT2C6). (studioinathens.com)
  • A macromolecular complex of proteins that includes DYSTROPHIN and DYSTROPHIN-ASSOCIATED PROTEINS. (curehunter.com)
  • 3) Seed germination was accompanied by the decrease in macromolecular substances such as soluble sugar, soluble starch, and soluble protein. (scirp.org)
  • Extracted from tobacco or its fragment, tobacco extract usually contains a large quantity of macromolecular substances such as protein, pectin, and starch, which are suspected to have an adverse effect on the quality of tobacco extract [ 4 ]. (hindawi.com)
  • There are several types of structures for covalent substances, including individual molecules, molecular structures, macromolecular structures and giant covalent structures. (wikipedia.org)
  • Most biological reactions rely on interplay between binding and changes in both macromolecular structure and dynamics. (duke.edu)
  • Hyaluronic acid preparation is mainly a biological macromolecular substance extracted and refined from cockscomb and human umbilical cord, which appears as sodium hyaluronate sa. (himfr.com)
  • The papers are divided into sections concerning the hydration of: ions, nonionic substances, biological and macromolecular substances, surfactants as well as a section containing methods, models and theo- ries, which may stimulate investigations on hydrations. (springer.com)
  • Any reaction that depends on the available volume can be affected by macromolecular crowding, but the effects of crowding in cells are complex and difficult to track. (nih.gov)
  • The enclosed chamber is uniquely designed to be impermeable to substances, like liquid and cells, that possibly can interfere with the supply of the oxygen permeating through the membrane to the enzymatic reaction. (google.com.au)
  • 7. A device of claim 4 wherein said optical sensor comprises an optical substance in contact with said enzyme for optical reaction with the product or reactant from the enzymatic reaction and a fiber optic for sensing the optical reaction which functions as a measure of the analyte. (google.com.au)
  • Fever is the reaction of the thermoregulatory apparatus to those macromolecular substances, called pyrogens, that affect the chemoreceptors. (thefreedictionary.com)
  • Clarke, RM & Hardy, RN 1969, ' An analysis of the mechanism of cessation of uptake of macro‐molecular substances by the intestine of the young rat ('closure') ', Journal of Physiology , vol. 204, no. 1, pp. 127-134. (edu.au)
  • This phenomenon may influence macromolecular drug uptake. (sigmaaldrich.com)
  • Our data can be used in modeling of drug uptake, and give indications on ECM components to be targeted to increase the uptake of macromolecular substances. (sigmaaldrich.com)
  • Macromolecular assemblies: greater than their parts. (biomedsearch.com)
  • Increasingly powerful methods of analysis have opened up complex macromolecular assemblies to scrutiny at atomic detail. (biomedsearch.com)
  • Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway. (nih.gov)
  • Roman Saliwanchik [5 7] ABSTRACT 10 Claims, No Drawings 1 METHOD FOR BINDING ANTITHROMBOTIC OR ANTICLOTTING SUBSTANCES TO A SUSCEPTIBLE MATERIAL INVOLVING THE USE OF AN AROMATIC SULFONYL NITRENE BACKGROUND OF THE INVENTION Technological advances in the last few decades have brought the mammalian body in intimate contact with a variety of devices incorporating foreign materials which were not present in the evolution of theirsysterns. (google.com)
  • The aim of this contribution is to describe advantages and disadvantages of transdermal administration of drugs and the structure of the skin as a barrier preventing penetration of any heterogeneous substances into the body. (omicsonline.org)
  • a sweet white (or brownish yellow) crystalline substance, of a sandy or granular consistency, obtained by crystallizing the evaporated juice of certain plants, as the sugar cane, sorghum, beet root, sugar maple, etc. (definitions.net)
  • The diffusion of any substance within the CNS may be affected by a number of properties associated with the brain microenvironment, e.g., the volume fraction, geometry, width, and local viscosity of the ECS, as well as interactions with cell surfaces, the extracellular matrix, and components of the interstitial fluid. (nih.gov)
  • Our studies focus on the interactions between water, cellular and macromolecular systems, and physicochemical parameters such as the various activities of solutes. (spaceref.com)
  • WHO HQ Library catalog › Results of search for 'su:{Macromolecular Substances. (who.int)
  • Given the limited accuracy of force fields, macromolecular simulations sometimes produce results that are at not in complete and quantitative accordance with experiments. (nih.gov)
  • The development in the field of pharmaceutical dosage forms results in discovery of additional highly sophisticated drug delivery systems that allow maintaining constant level of active substance in organism. (omicsonline.org)
  • Many of these records describe chemical substances. (bionity.com)
  • Since 1978, berberine was classed as a toxic substance in Singapore. (hindawi.com)
  • Prominent among these is the 'cumulative-damage' hypothesis, which suggests that accumulation of toxic substances or of macromolecular damage gradually destroys individual neurons. (alzforum.org)
  • 17. A device of claim 1 wherein said container contains an oxygen transport substance. (google.com.au)
  • 18. A device of claim 17 wherein said oxygen transport substance is a perfluorocarbon or derivative thereof. (google.com.au)
  • This graph shows the total number of publications written about "Macromolecular Substances" by people in this website by year, and whether "Macromolecular Substances" was a major or minor topic of these publications. (rtrn.net)
  • Physical and chemical parameters affecting the distribution of substances in environmental media. (vsb.cz)
  • Purification and macromolecular properties of a sialic acid-specific lectin from the slug Limax flavus. (biomedsearch.com)
  • Pyrogens are classified as either exogenous, that is, entering the body from without (for example, microbes and the products of their life activities), or endogenous, that is, formed in the body itself (for example, products secreted by leukocytes in the process of phagocytosis or substances that appear as a result of damage to the cell-tissue structure). (thefreedictionary.com)
  • Regardless of whether a drug or other substance crosses the blood-brain barrier or is directly applied within the brain, distribution within the brain microenvironment usually must involve diffusion over some distance within the brain ECS. (nih.gov)
  • The solution self-assembly of macromolecular amphiphiles offers an efficient, bottom-up strategy for producing well-defined nanocarriers, with applications ranging from drug delivery to nanoreactors. (nih.gov)
  • However, transdermal drug delivery often faces the problem of insufficient or no penetration of active pharmaceutical substances through the skin. (omicsonline.org)
  • This is evidenced by our Level 3 (at world standard) and Level 4 (above world standard) star ratings in the latest Excellence in Research for Australia (ERA) for Chemical Sciences and Macromolecular and materials areas of research. (edu.au)
  • The criteria should, in particular, promote sustainable sourcing of materials, limited use of hazardous substances, high-quality and high-performance products which are fit-for-use and are designed to minimise waste production. (europa.eu)
  • A theory for water and macromolecular transport in the pulmonary artery wall with a detailed comparison to the aorta. (rtrn.net)
  • Water is arguably a ubiquitous substance which is certainly not confined to Earth. (spaceref.com)
  • Rubber is a collective term for macromolecular substances of natural rubber (NR) or synthetic rubber (SR) origin. (environmental-expert.com)
  • A glycosan is a general term for a macromolecular substance which is hydrolyzed to yield almost exclusively sugars. (springer.com)
  • Since there is not a generic description covering both of these processes, a substance which inhibits platelet aggregation will hereinafter be referred to as antithrombotic and a substance which inhibits fibrin clot formation will hereinafter be referred to as anticlotting. (google.com)
  • Best quality pure hyaluronic acid CAS 9004-61-9 in raw material bulk Hyaluronic Acid Description Pure 99% HA ( hyaluronic acid ) is a straight-chain macromolecular mucopolysaccharide consisting of repeated dis. (himfr.com)