Radionuclide imaging of the LYMPHATIC SYSTEM.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.
A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.
Edema due to obstruction of lymph vessels or disorders of the lymph nodes.
Radiographic study of the lymphatic system following injection of dye or contrast medium.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.
Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
A system of organs and tissues that process and transport immune cells and LYMPH.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A transient dilatation of the lymphatic vessels.
Inorganic compounds that contain tin as an integral part of the molecule.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
The presence of chyle in the thoracic cavity. (Dorland, 27th ed)
Presence of milky lymph (CHYLE) in the PERITONEAL CAVITY, with or without infection.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
The external junctural region between the lower part of the abdomen and the thigh.
An opaque, milky-white fluid consisting mainly of emulsified fats that passes through the lacteals of the small intestines into the lymphatic system.
External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Tumors or cancer of the SKIN.
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Tumors or cancer of the human BREAST.
A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
The period during a surgical operation.
The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.
Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. (1/67)

PURPOSE: To compare the effect of pathologic sentinel lymph node (SLN) status with that of other known prognostic factors on recurrence and survival in patients with stage I or II cutaneous melanoma. PATIENTS AND METHODS: We reviewed the records of 612 patients with primary cutaneous melanoma who underwent lymphatic mapping and SLN biopsy between January 1991 and May 1995 to determine the effects of tumor thickness, ulceration, Clark level, location, sex, and SLN pathologic status on disease-free and disease-specific survival. RESULTS: In the 580 patients in whom lymphatic mapping and SLN biopsy were successful, the SLN was positive by conventional histology in 85 patients (15%) but negative in 495 patients (85%). SLN status was the most significant prognostic factor with respect to disease-free and disease-specific survival by univariate and multiple covariate analyses. Although tumor thickness and ulceration influenced survival in SLN-negative patients, they provided no additional prognostic information in SLN-positive patients. CONCLUSION: Lymphatic mapping and SLN biopsy is highly accurate in staging nodal basins at risk for regional metastases in primary melanoma patients and identifies those who may benefit from earlier lymphadenectomy. Furthermore, pathologic status of the SLN in these patients with clinically negative nodes is the most important prognostic factor for recurrence. The information from SLN biopsy is particularly helpful in establishing stratification criteria for future adjuvant trials.  (+info)

Lymphoscintigraphy in tumors of the head and neck using double tracer technique. (2/67)

Knowledge of possible lymphatic drainage may facilitate planning of surgery for patients with head and neck tumors. Therefore, the aim of this study was to present a method of lymphoscintigraphy with special attention to an accurate correlation of lymphatic drainage to anatomic regions. METHODS: Lymphoscintigraphy was performed using a double tracer technique before surgery in a total of 75 patients with squamous cell carcinoma of the head and neck. All patients received 100 MBq 99mTc-colloid at three to four peritumoral sites. A perchlorate solution (2 mL) was given orally to block salivary glands and the thyroid gland. Patients received 50 MBq 99mTc-pertechnetate intravenously for body contouring 20 min postinjection. Planar images were obtained over 5 min each, at 30 min and 4 h postinjection from anterior, right lateral and left lateral views with a large-field-of-view gamma camera. Lymphatic drainage was assessed by visual inspection and assigned to six cervical compartments. RESULTS: Neither the salivary glands nor the thyroid gland were seen in any of the patients. In 22 of 75 patients (29.3%), the injection site was the only focal tracer uptake seen. In contrast, lymphatic drainage was identified in the remaining 53 patients (70.7%), and lymph nodes could be assigned easily to the six cervical compartments. Of 75 patients, 36 (48%) exhibited ipsilateral lymphatic drainage. In addition, 17 patients (22.7%) with unilateral tumor showed bilateral (n = 12), contralateral (n = 2) or retropharyngeal (n = 3) lymphatic drainage. In 3 of these 17 patients, bilateral lymph node metastases were proven. A subgroup of 12 patients (16%) exhibited N2c nodal status, despite a unilateral localized primary tumor. In 3 of these 12 patients, surgery was extended as a result of scintigraphic findings from unilateral toward bilateral neck dissection, and histology confirmed nodal involvement in these patients. CONCLUSION: Lymphoscintigraphy using the double tracer technique allows an accurate correlation of lymphatic drainage to the six cervical compartments. This may provide the basis for a re-evaluation of its impact in treatment planning of patients with head and neck tumors.  (+info)

Lymphoscintigraphy using (99m)Tc filtered sulfur colloid in chylothorax: a case report. (3/67)

OBJECTIVE: A 66-y-old man was diagnosed with esophageal carcinoma and underwent a right thoracotomy and esophagectomy. Postoperatively, a recurring right pleural effusion developed. Because an attempt at lymphangiography failed, lymphoscintigraphy was suggested. Because of the inability to obtain radiolabeled albumin, dextran, or nanocolloid, we used filtered sulfur colloid. (0.1 um). The study confirmed the diagnosis of chylothorax.  (+info)

Reversal of abnormal lymphoscintigraphy after placement of venous stents for correction of associated venous obstruction. (4/67)

PURPOSE: The purpose of this study was to report improvement or normalization of abnormal lymphoscintigraphy in swollen lower limbs after correction of associated venous stenosis by balloon dilatation and placement of venous stent of the iliac veins. MATERIAL: Twenty-six patients with lower-limb swelling underwent balloon dilatation and placement of venous stent of the iliac veins for correction of venous stenosis. Technetium 99M-sulfur colloid lymphoscintigraphy was also abnormal (8 absent, 18 reduced) before stent placement in all 26 limbs, suggesting combined venous/lymphatic etiology for the limb swelling. Median age was 53 years. Male-to-female ratio was 1:8 and left-to-right ratio, 3:1. Fifteen patients had limb pain associated with the swelling. Severity of venous stenosis was generally underestimated by preoperative transfemoral venography as compared with intravascular ultrasound, (mean, 50% versus 77%); in five limbs (19%), transfemoral venography altogether failed to identify the venous lesion evident on intravascular ultrasound. The etiology of venous obstruction was post-thrombotic in nine limbs and nonthrombotic (web, stricture, or May-Thurner syndrome) in 17 limbs. RESULTS: Poststent lymphoscintigraphy completely normalized in 10 limbs, improved but remained abnormal in 9, and remained unchanged in 7. Clinical follow-up (mean, 1 year) showed improvement in swelling in 16 of 26 limbs (P <.022), with complete resolution of swelling in six; degree of pain also improved (P <.02), with total relief of pain in 9 of 15 patients. There was also significant improvement in all categories of a quality of life questionnaire. CONCLUSION: These findings suggest that patients with a diagnosis of lymphedema made on the basis of lymphoscintigraphy alone and consigned to conservative therapy on that basis may benefit from additional venous investigations regardless of clinical presentation suggestive of lymphedema. This report supports the practice of aggressively searching for a venous basis of edema in these patients. Correction of the venous lesion may result in normalization or improvement of the lymphoscintigraphic abnormality and in any case may yield significant symptom relief, even in some limbs where the lymphoscintigraphic abnormality failed to improve after placement of venous stent.  (+info)

Treatment of symptomatic primary chylous disorders. (5/67)

PURPOSE: Primary chylous disorders (PCDs) are rare. Rupture of dilated lymph vessels (lymphangiectasia) may result in chylous ascites, chylothorax, or leakage of chyle through chylocutanous fistulas in the lower limbs or genitalia. Chyle may reflux through incompetent lymphatics, causing lymphedema. To assess the efficacy of surgical treatment, we reviewed our experience. METHODS: The clinical data of 35 patients with PCDs treated between January 1, 1976, and August 31, 2000, were reviewed retrospectively. RESULTS: Fifteen men and 20 women (mean age, 29 years; range, 1 day-81 years) presented with PCDs. Sixteen (46%) patients had chylous ascites, and 19 (54%) had chylothorax (20 patients), and of these, 10 (29%) had both. In 16 patients, reflux of chyle into the pelvic or lower limb lymphatics caused lymphedema (14, 88%) or lymphatic leak through cutaneous fistulae (11, 69%). Presenting symptoms included lower-limb edema (19, 54%), dyspnea (17, 49%), scrotal or labial edema (15, 43%), or abdominal distention (13, 37%). Primary lymphangiectasia presented alone in 23 patients (66%), and it was associated with clinical syndromes or additional pathologic findings in 12 (yellow nail syndrome in 4, lymphangiomyomatosis in 3, unknown in 3, Prasad syndrome (hypogammaglobulinemia, lymphadenopathy, and pulmonary insufficiency) in 1, and thoracic duct cyst in 1). Twenty-one (60%) patients underwent 26 surgical procedures. Preoperative imaging included computed tomography scan in 15 patients, magnetic resonance imaging in 3, lymphoscintigraphy in 12, and lymphangiography in 14. Fifteen patients underwent 18 procedures for chylous ascites or pelvic reflux. Ten (56%) procedures were resection of retroperitoneal/mesenteric lymphatics with or without sclerotherapy of lymphatics, 4 (22%) were lymphovenous anastomoses or grafts, 3 (17%) were peritoneovenous shunts, and 1 (6%) patient had a hysterectomy. Six patients underwent eight procedures for chylothorax, including thoracotomy with decortication and pleurodesis (4 procedures), thoracoscopic decortication (1 patient), ligation of thoracic duct (2 procedures), and resection of thoracic duct cyst (1 patient). Postoperative mean follow-up was 54 months (range, 0.3-276). Early complications included wound infections in 3 patients, elevated liver enzymes in 1, and peritoneovenous shunt occlusion with innominate vein occlusion in 1. All patients improved initially, but four (19%) had recurrence of symptoms at a mean of 25 months (range, 1-43). Three patients had postoperative lymphoscintigraphy confirming improved lymphatic transport and diminished reflux. One patient died 12 years postoperatively, from causes unrelated to PCD. CONCLUSIONS: More than half of the patients with PCDs require surgical treatment, and surgery should be considered in patients with significant symptoms of PCD. Lymphangiography is recommended to determine anatomy and the site of the lymphatic leak, especially if lymphovenous grafting is planned. All patients had initial benefit postoperatively and two thirds of patients demonstrated durable clinical improvement after surgical treatment.  (+info)

Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood. (6/67)

The object of this study was to develop a new technique for the quantitative measurement of lymphatic function. The rate of clearance of radiolabeled protein from a subcutaneous depot is supplemented by measurement of the appearance of the protein in venous blood. This initial study was performed on normal arms, with a view to subsequent clinical application such as in the investigation of women with breast cancer--related lymphedema (BCRL). METHODS: Fourteen healthy volunteers (12 women, 2 men) and 8 women awaiting surgery for breast cancer were recruited for the study. Each received subcutaneous depot injection of protein solution in the second dorsal web space of each hand, labeled with (111)In on one side and with (99m)Tc on the other side. Human serum albumin (HSA) was the protein used in the first 8 subjects and human polyclonal immunoglobulin G (HIgG) was used thereafter. The activity at each depot was measured at regular intervals using a collimated sodium iodide scintillation detector, and the activity in venous blood sampled from both arms was measured in an automatic sample counter. RESULTS: (99m)Tc-HSA cleared from the depot consistently faster than (111)In-HSA (P = 0.001). The proportions of radionuclide remaining bound to protein in venous blood were higher for (99m)Tc than for (111)In. HIgG displayed improved labeling stability for both nuclides, reflected in equal rates of clearance. Blood activity rose steadily after an early latent phase and for HIgG correlated strongly with the rate of clearance from the depot (P < 0.001). Marked variation between individuals was observed. CONCLUSION: A dual-isotope technique relies on identical behavior of the 2 radiopharmaceuticals used. This study shows that this is the case with respect to HIgG but not HSA. (99m)Tc-HSA cleared faster than (111)In-HSA and yet displayed better in vivo labeling stability. We conclude that (111)In dissociates from HSA in the depot but then becomes locally bound. Using HIgG, a close correlation was observed between the rates of clearance from the depot and the appearance in venous blood. This finding suggests that HIgG would be a suitable marker for subsequent dual-isotope studies on women with BCRL.  (+info)

Whole-body lymphoscintigraphy using transmission scans. (7/67)

OBJECTIVE: Our objective was to show the advantages of performing whole-body lymphoscintigraphy using transmission sources. This technique should decrease scanning time, help locate the sentinel lymph node, and decrease radiation exposure to the technologist. METHODS: Twenty patients with proven melanoma received 18.5 MBq (0.5 mCi) filtered (0.22 microm) (99m)Tc-sulfur colloid in a 0.2-mL volume, administered as multiple intradermal or subcutaneous injections around the known melanoma lesion or scar. All 20 patients underwent serial static imaging immediately after the injection, along with whole-body scanning after the static imaging. The static emission images were acquired for 5 min and the transmission images for 1 min using a 256 x 256 matrix. The whole-body transmission scans were acquired after the whole-body emission scans. The transmission scans were obtained with the same parameters as the emission scans, with the addition of placement of a (57)Co sheet source on one of the detectors of the large-field-of-view dual-head camera. The planar static axial images (transmission, emission) were compared with the whole-body images (transmission, emission) to determine whether the same number of lymph nodes was visualized with each technique. Posterior outlines were obtained through computer manipulation of anterior transmission images. RESULTS: In all 20 patients, the number of lymph nodes seen on the static images was the same as that seen on the whole-body emission and transmission images. The whole-body emission and transmission scanning time was an average of 30 min less than the time required to acquire the serial static images. CONCLUSION: The anatomic location of the sentinel lymph node is seen more easily on whole-body images, both anterior transmission and posterior transmission, than on planar static images. Whole-body emission and transmission imaging decreased scanning time and thus improved patient comfort and throughput. Technologists received less radiation exposure when handling the (57)Co source only twice during whole-body imaging, as opposed to several times during static imaging.  (+info)

Contamination problem with sentinel node localization procedure: a case study. (8/67)

Lymphoscintigraphy for sentinel node (SN) localization was performed on a 60-y-old man with a melanoma on his back. Skin contamination occurred as a result of the radiopharmaceutical dose administration. Skin contamination could result in a misinterpretation of the SN location. Careful observation of the procedure avoided a misinterpretation with this study.  (+info)

Lymphoscintigraphy is a medical imaging technique that uses radioactive tracers to examine the lymphatic system, specifically the lymph nodes and vessels. In this procedure, a small amount of radioactive material is injected into the area of interest, usually an extremity or the site of a surgical incision. The tracer then travels through the lymphatic channels and accumulates in the regional lymph nodes. A specialized camera called a gamma camera detects the radiation emitted by the tracer and creates images that reveal the function and anatomy of the lymphatic system.

Lymphoscintigraphy is often used to diagnose and assess conditions affecting the lymphatic system, such as lymphedema, cancer metastasis to lymph nodes, or unusual lymphatic flow patterns. It can help identify sentinel lymph nodes (the first node(s) to receive drainage from a tumor) in patients with melanoma and breast cancer, which is crucial for surgical planning and staging purposes.

In summary, lymphoscintigraphy is a non-invasive imaging technique that utilizes radioactive tracers to visualize the lymphatic system's structure and function, providing valuable information for diagnostic and therapeutic decision-making in various clinical scenarios.

Technetium compounds refer to chemical substances that contain the radioactive technetium (Tc) element. Technetium is a naturally rare element and does not have any stable isotopes, making it only exist in trace amounts in the Earth's crust. However, it can be produced artificially in nuclear reactors.

Technetium compounds are widely used in medical imaging as radioactive tracers in diagnostic procedures. The most common technetium compound is Technetium-99m (Tc-99m), which has a half-life of 6 hours and emits gamma rays that can be detected by external cameras. Tc-99m is often bound to various pharmaceuticals, such as methylene diphosphonate (MDP) or human serum albumin (HSA), to target specific organs or tissues in the body.

Technetium compounds are used in a variety of diagnostic procedures, including bone scans, lung perfusion scans, myocardial perfusion imaging, and brain scans. They provide valuable information about organ function, blood flow, and tissue metabolism, helping doctors diagnose various medical conditions such as cancer, heart disease, and bone fractures.

It is important to note that technetium compounds should only be used under the supervision of trained medical professionals due to their radioactive nature. Proper handling, administration, and disposal procedures must be followed to ensure safety and minimize radiation exposure.

Technetium Tc 99m Sulfur Colloid is a radioactive tracer used in medical imaging procedures, specifically in nuclear medicine. It is composed of tiny particles of sulfur colloid that are labeled with the radioisotope Technetium-99m. This compound is typically injected into the patient's body, where it accumulates in certain organs or tissues, depending on the specific medical test being conducted.

The radioactive emissions from Technetium Tc 99m Sulfur Colloid are then detected by a gamma camera, which produces images that can help doctors diagnose various medical conditions, such as liver disease, inflammation, or tumors. The half-life of Technetium-99m is approximately six hours, which means that its radioactivity decreases rapidly and is eliminated from the body within a few days.

Technetium Tc 99m Aggregated Albumin is a radiopharmaceutical preparation used in diagnostic imaging. It consists of radioactive technetium-99m (^99m^Tc) chemically bonded to human serum albumin, which has been aggregated to increase its size and alter its clearance from the body.

The resulting compound is injected into the patient's bloodstream, where it accumulates in the reticuloendothelial system (RES), including the liver, spleen, and bone marrow. The radioactive emission of technetium-99m can then be detected by a gamma camera, producing images that reflect the distribution and function of the RES.

This imaging technique is used to diagnose and monitor various conditions, such as liver disease, inflammation, or tumors. It provides valuable information about the patient's health status and helps guide medical decision-making.

Antimony is a toxic metallic element with the symbol Sb and atomic number 51. It exists in several allotropic forms and can be found naturally as the mineral stibnite. Antimony has been used for centuries in various applications, including medicinal ones, although its use in medicine has largely fallen out of favor due to its toxicity.

In a medical context, antimony may still be encountered in certain medications used to treat parasitic infections, such as pentavalent antimony compounds (e.g., sodium stibogluconate and meglumine antimoniate) for the treatment of leishmaniasis. However, these drugs can have significant side effects and their use is typically reserved for severe cases that cannot be treated with other medications.

It's important to note that exposure to antimony in high concentrations or over prolonged periods can lead to serious health issues, including respiratory problems, skin irritation, gastrointestinal symptoms, and even neurological damage. Therefore, handling antimony-containing substances should be done with caution and appropriate safety measures.

A sentinel lymph node biopsy is a surgical procedure used in cancer staging to determine if the cancer has spread beyond the primary tumor to the lymphatic system. This procedure involves identifying and removing the sentinel lymph node(s), which are the first few lymph nodes to which cancer cells are most likely to spread from the primary tumor site.

The sentinel lymph node(s) are identified by injecting a tracer substance (usually a radioactive material and/or a blue dye) near the tumor site. The tracer substance is taken up by the lymphatic vessels and transported to the sentinel lymph node(s), allowing the surgeon to locate and remove them.

The removed sentinel lymph node(s) are then examined under a microscope for the presence of cancer cells. If no cancer cells are found, it is unlikely that the cancer has spread to other lymph nodes or distant sites in the body. However, if cancer cells are present, further lymph node dissection and/or additional treatment may be necessary.

Sentinel lymph node biopsy is commonly used in the staging of melanoma, breast cancer, and some types of head and neck cancer.

Lymphedema is a chronic condition characterized by swelling in one or more parts of the body, usually an arm or leg, due to the accumulation of lymph fluid. This occurs when the lymphatic system is unable to properly drain the fluid, often as a result of damage or removal of lymph nodes, or because of a genetic abnormality that affects lymphatic vessel development.

The swelling can range from mild to severe and may cause discomfort, tightness, or a feeling of heaviness in the affected limb. In some cases, lymphedema can also lead to skin changes, recurrent infections, and reduced mobility. The condition is currently not curable but can be managed effectively with various treatments such as compression garments, manual lymphatic drainage, exercise, and skincare routines.

Lymphography is not a commonly used term in current medical practice. However, historically, it referred to a radiographic imaging technique that involved the injection of a contrast material into the lymphatic system to visualize the lymph nodes and lymph vessels. This procedure was used primarily for diagnostic purposes, particularly in the evaluation of cancerous conditions like lymphoma or melanoma.

The process typically involved injecting a radiopaque substance into the interstitial tissue, which would then be taken up by the lymphatic vessels and transported to the regional lymph nodes. X-ray imaging was used to track the progression of the contrast material, creating detailed images of the lymphatic system.

Due to advancements in medical imaging technology, lymphography has largely been replaced by other non-invasive imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scans. These modern methods provide high-resolution images of the body's internal structures without requiring invasive procedures or the use of contrast materials.

Lymph nodes are small, bean-shaped organs that are part of the immune system. They are found throughout the body, especially in the neck, armpits, groin, and abdomen. Lymph nodes filter lymph fluid, which carries waste and unwanted substances such as bacteria, viruses, and cancer cells. They contain white blood cells called lymphocytes that help fight infections and diseases by attacking and destroying the harmful substances found in the lymph fluid. When an infection or disease is present, lymph nodes may swell due to the increased number of immune cells and fluid accumulation as they work to fight off the invaders.

Colloids are a type of mixture that contains particles that are intermediate in size between those found in solutions and suspensions. These particles range in size from about 1 to 1000 nanometers in diameter, which is smaller than what can be seen with the naked eye, but larger than the molecules in a solution.

Colloids are created when one substance, called the dispersed phase, is dispersed in another substance, called the continuous phase. The dispersed phase can consist of particles such as proteins, emulsified fats, or finely divided solids, while the continuous phase is usually a liquid, but can also be a gas or a solid.

Colloids are important in many areas of medicine and biology, including drug delivery, diagnostic imaging, and tissue engineering. They are also found in nature, such as in milk, blood, and fog. The properties of colloids can be affected by factors such as pH, temperature, and the presence of other substances, which can influence their stability and behavior.

A gamma camera, also known as a scintillation camera, is a device used in nuclear medicine to image gamma-emitting radionuclides in the body. It detects gamma radiation emitted by radioisotopes that have been introduced into the body, usually through injection or ingestion. The camera consists of a large flat crystal (often sodium iodide) that scintillates when struck by gamma rays, producing light flashes that are detected by an array of photomultiplier tubes.

The resulting signals are then processed by a computer to generate images that reflect the distribution and concentration of the radionuclide in the body. Gamma cameras are used in a variety of medical imaging procedures, including bone scans, lung scans, heart scans (such as myocardial perfusion imaging), and brain scans. They can help diagnose conditions such as cancer, heart disease, and neurological disorders.

Rosaniline dyes are a type of basic dye that were first synthesized in the late 19th century. They are named after rosaniline, which is a primary chemical used in their production. Rosaniline dyes are characterized by their ability to form complexes with metal ions, which can then bind to proteins and other biological molecules. This property makes them useful as histological stains, which are used to highlight specific structures or features within tissues and cells.

Rosaniline dyes include a range of different chemicals, such as methyl violet, crystal violet, and basic fuchsin. These dyes are often used in combination with other staining techniques to provide contrast and enhance the visibility of specific cellular components. For example, they may be used to stain nuclei, cytoplasm, or other structures within cells, allowing researchers and clinicians to visualize and analyze tissue samples more effectively.

It's worth noting that some rosaniline dyes have been found to have potential health hazards, particularly when used in certain forms or concentrations. Therefore, it's important to follow proper safety protocols when handling these chemicals and to use them only under the guidance of trained professionals.

The term "axilla" is used in anatomical context to refer to the armpit region, specifically the space located lateral to the upper part of the chest wall and medial to the upper arm. This area contains a number of important structures such as blood vessels, nerves, and lymph nodes, which play a critical role in the health and functioning of the upper limb. Understanding the anatomy of the axilla is essential for medical professionals performing various procedures, including surgeries and injections, in this region.

Lymphatic metastasis is the spread of cancer cells from a primary tumor to distant lymph nodes through the lymphatic system. It occurs when malignant cells break away from the original tumor, enter the lymphatic vessels, and travel to nearby or remote lymph nodes. Once there, these cancer cells can multiply and form new tumors, leading to further progression of the disease. Lymphatic metastasis is a common way for many types of cancer to spread and can have significant implications for prognosis and treatment strategies.

Technetium is not a medical term itself, but it is a chemical element with the symbol Tc and atomic number 43. However, in the field of nuclear medicine, which is a branch of medicine that uses small amounts of radioactive material to diagnose or treat diseases, Technetium-99m (a radioisotope of technetium) is commonly used for various diagnostic procedures.

Technetium-99m is a metastable nuclear isomer of technetium-99, and it emits gamma rays that can be detected outside the body to create images of internal organs or tissues. It has a short half-life of about 6 hours, which makes it ideal for diagnostic imaging since it decays quickly and reduces the patient's exposure to radiation.

Technetium-99m is used in a variety of medical procedures, such as bone scans, lung scans, heart scans, liver-spleen scans, brain scans, and kidney scans, among others. It can be attached to different pharmaceuticals or molecules that target specific organs or tissues, allowing healthcare professionals to assess their function or identify any abnormalities.

The lymphatic system is a complex network of organs, tissues, vessels, and cells that work together to defend the body against infectious diseases and also play a crucial role in the immune system. It is made up of:

1. Lymphoid Organs: These include the spleen, thymus, lymph nodes, tonsils, adenoids, and Peyer's patches (in the intestines). They produce and mature immune cells.

2. Lymphatic Vessels: These are thin tubes that carry clear fluid called lymph towards the heart.

3. Lymph: This is a clear-to-white fluid that contains white blood cells, mainly lymphocytes, which help fight infections.

4. Other tissues and cells: These include bone marrow where immune cells are produced, and lymphocytes (T cells and B cells) which are types of white blood cells that help protect the body from infection and disease.

The primary function of the lymphatic system is to transport lymph throughout the body, collecting waste products, bacteria, viruses, and other foreign substances from the tissues, and filtering them out through the lymph nodes. The lymphatic system also helps in the absorption of fats and fat-soluble vitamins from food in the digestive tract.

Radiopharmaceuticals are defined as pharmaceutical preparations that contain radioactive isotopes and are used for diagnosis or therapy in nuclear medicine. These compounds are designed to interact specifically with certain biological targets, such as cells, tissues, or organs, and emit radiation that can be detected and measured to provide diagnostic information or used to destroy abnormal cells or tissue in therapeutic applications.

The radioactive isotopes used in radiopharmaceuticals have carefully controlled half-lives, which determine how long they remain radioactive and how long the pharmaceutical preparation remains effective. The choice of radioisotope depends on the intended use of the radiopharmaceutical, as well as factors such as its energy, range of emission, and chemical properties.

Radiopharmaceuticals are used in a wide range of medical applications, including imaging, cancer therapy, and treatment of other diseases and conditions. Examples of radiopharmaceuticals include technetium-99m for imaging the heart, lungs, and bones; iodine-131 for treating thyroid cancer; and samarium-153 for palliative treatment of bone metastases.

The use of radiopharmaceuticals requires specialized training and expertise in nuclear medicine, as well as strict adherence to safety protocols to minimize radiation exposure to patients and healthcare workers.

Lymphangiectasis is a medical condition characterized by the dilation and abnormal expansion of lymphatic vessels, which are responsible for transporting lymph fluid throughout the body. These dilated lymphatic vessels can be found in various tissues and organs, including the intestines, lungs, or other parts of the body.

In the case of intestinal lymphangiectasis (also known as Waldmann's disease), the lymphatic vessels in the small intestine become enlarged, leading to impaired absorption of nutrients and lymph fluid. This can result in protein-losing enteropathy, malnutrition, diarrhea, and edema (swelling) due to the loss of proteins and lymphatic fluids into the gastrointestinal tract.

Pulmonary lymphangiectasis is a rare congenital disorder where the lymphatic vessels in the lungs are abnormally developed and dilated, causing respiratory distress, recurrent lung infections, and chylous effusions (accumulation of milky lymph fluid in the pleural space surrounding the lungs).

Treatment for lymphangiectasis depends on the underlying cause and severity of the condition. It may involve dietary modifications, medications to manage symptoms, or surgical interventions in some cases.

Tin compounds refer to chemical substances that contain tin (Sn) combined with one or more other elements. Tin can form various types of compounds, including oxides, sulfides, halides, and organometallic compounds. These compounds have different properties and uses depending on the other element(s) they are combined with.

For example:

* Tin (IV) oxide (SnO2) is a white powder used as an opacifying agent in glass and ceramics, as well as a component in some types of batteries.
* Tin (II) sulfide (SnS) is a black or brown solid used in the manufacture of some types of semiconductors.
* Tin (IV) chloride (SnCl4) is a colorless liquid used as a catalyst in the production of polyvinyl chloride (PVC) and other plastics.
* Organotin compounds, such as tributyltin (TBT), are used as biocides and antifouling agents in marine paints. However, they have been found to be toxic to aquatic life and are being phased out in many countries.

Radionuclide imaging, also known as nuclear medicine, is a medical imaging technique that uses small amounts of radioactive material, called radionuclides or radiopharmaceuticals, to diagnose and treat various diseases and conditions. The radionuclides are introduced into the body through injection, inhalation, or ingestion and accumulate in specific organs or tissues. A special camera then detects the gamma rays emitted by these radionuclides and converts them into images that provide information about the structure and function of the organ or tissue being studied.

Radionuclide imaging can be used to evaluate a wide range of medical conditions, including heart disease, cancer, neurological disorders, gastrointestinal disorders, and bone diseases. The technique is non-invasive and generally safe, with minimal exposure to radiation. However, it should only be performed by qualified healthcare professionals in accordance with established guidelines and regulations.

Chylothorax is a medical condition characterized by the accumulation of lymphatic fluid called chyle in the pleural space, which is the space between the lungs and the chest wall. Chyle is a milky-white fluid that contains nutrients, electrolytes, and immune cells, and it is normally transported through the thoracic duct to the bloodstream.

Chylothorax can occur due to various reasons, such as trauma, surgery, tumors, or congenital abnormalities that disrupt the normal flow of chyle. As a result, chyle leaks into the pleural space, causing symptoms such as cough, chest pain, difficulty breathing, and fever.

The diagnosis of chylothorax is usually made through imaging studies such as chest X-ray or CT scan, and confirmed by analyzing the fluid for the presence of chylomicrons, which are lipid particles found in chyle. The treatment options for chylothorax include dietary modifications, such as a low-fat diet with medium-chain triglycerides, chest tube drainage, and surgical interventions such as thoracic duct ligation or pleurodesis.

Chylous ascites is a medical condition characterized by the accumulation of milky, fat-containing fluid in the peritoneal cavity, which is the space within the abdomen that contains the intestines, liver, and other organs. The fluid, called chyle, is normally found in the lymphatic system and is formed when dietary fats are absorbed from the small intestine.

Chylous ascites can occur as a result of damage to the lymphatic vessels that transport chyle from the intestines to the bloodstream. This damage can be caused by various conditions, such as trauma, surgery, tumors, inflammation, or congenital abnormalities. When the lymphatic vessels are damaged, chyle leaks into the peritoneal cavity and accumulates there, leading to ascites.

Symptoms of chylous ascites may include abdominal distension, pain, nausea, vomiting, and weight loss. The condition can be diagnosed through various tests, such as imaging studies or analysis of the fluid in the peritoneal cavity. Treatment typically involves addressing the underlying cause of the condition, as well as managing symptoms and preventing complications. This may include dietary modifications, medications to reduce lymphatic flow, or surgical interventions to repair damaged lymphatic vessels.

Melanoma is defined as a type of cancer that develops from the pigment-containing cells known as melanocytes. It typically occurs in the skin but can rarely occur in other parts of the body, including the eyes and internal organs. Melanoma is characterized by the uncontrolled growth and multiplication of melanocytes, which can form malignant tumors that invade and destroy surrounding tissue.

Melanoma is often caused by exposure to ultraviolet (UV) radiation from the sun or tanning beds, but it can also occur in areas of the body not exposed to the sun. It is more likely to develop in people with fair skin, light hair, and blue or green eyes, but it can affect anyone, regardless of their skin type.

Melanoma can be treated effectively if detected early, but if left untreated, it can spread to other parts of the body and become life-threatening. Treatment options for melanoma include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, depending on the stage and location of the cancer. Regular skin examinations and self-checks are recommended to detect any changes or abnormalities in moles or other pigmented lesions that may indicate melanoma.

In medical terms, the "groin" refers to the area where the lower abdomen meets the thigh. It is located on both sides of the body, in front of the upper part of each leg. The groin contains several important structures such as the inguinal canal, which contains blood vessels and nerves, and the femoral artery and vein, which supply blood to and from the lower extremities. Issues in this region, such as pain or swelling, may indicate a variety of medical conditions, including muscle strains, hernias, or infections.

Chyle is a milky, slightly opaque fluid that is present in the lymphatic system. It is formed in the small intestine during the digestion of food, particularly fats. Chyle consists of emulsified fat droplets (chylomicrons), proteins, electrolytes, and lymphocytes suspended in a watery solution. It is transported through the lacteals in the villi of the small intestine into the cisterna chyli and then to the thoracic duct, where it empties into the left subclavian vein. From there, it mixes with blood and circulates throughout the body. Chyle formation plays a crucial role in fat absorption and transportation in the human body.

Lymphatic irradiation is a medical procedure that involves the use of radiation therapy to target and treat the lymphatic system. This type of treatment is often used in cancer care, specifically in cases where cancer has spread to the lymph nodes. The goal of lymphatic irradiation is to destroy any remaining cancer cells in the lymphatic system and reduce the risk of cancer recurrence.

The procedure typically involves the use of a linear accelerator, which directs high-energy X-rays or electrons at the affected area. The radiation oncologist will determine the appropriate dose and duration of treatment based on the location and extent of the cancer, as well as the patient's overall health and medical history.

It is important to note that lymphatic irradiation can have side effects, including fatigue, skin changes, and swelling in the affected area. Patients may also experience longer-term side effects, such as lymphedema, which is a chronic swelling of the limbs due to damage to the lymphatic system.

Overall, lymphatic irradiation is an important tool in cancer care and can help improve outcomes for patients with cancer that has spread to the lymphatic system. However, it should be administered by trained medical professionals and accompanied by appropriate supportive care to manage side effects and optimize patient outcomes.

Lymph node excision is a surgical procedure in which one or more lymph nodes are removed from the body for the purpose of examination. This procedure is often conducted to help diagnose or stage various types of cancer, as malignant cells may spread to the lymphatic system and eventually accumulate within nearby lymph nodes.

During a lymph node excision, an incision is made in the skin overlying the affected lymph node(s). The surgeon carefully dissects the tissue surrounding the lymph node(s) to isolate them from adjacent structures before removing them. In some cases, a sentinel lymph node biopsy may be performed instead, where only the sentinel lymph node (the first lymph node to which cancer cells are likely to spread) is removed and examined.

The excised lymph nodes are then sent to a laboratory for histopathological examination, which involves staining and microscopic evaluation of the tissue to determine whether it contains any malignant cells. The results of this examination can help guide further treatment decisions and provide valuable prognostic information.

Preoperative care refers to the series of procedures, interventions, and preparations that are conducted before a surgical operation. The primary goal of preoperative care is to ensure the patient's well-being, optimize their physical condition, reduce potential risks, and prepare them mentally and emotionally for the upcoming surgery.

Preoperative care typically includes:

1. Preoperative assessment: A thorough evaluation of the patient's overall health status, including medical history, physical examination, laboratory tests, and diagnostic imaging, to identify any potential risk factors or comorbidities that may impact the surgical procedure and postoperative recovery.
2. Informed consent: The process of ensuring the patient understands the nature of the surgery, its purpose, associated risks, benefits, and alternative treatment options. The patient signs a consent form indicating they have been informed and voluntarily agree to undergo the surgery.
3. Preoperative instructions: Guidelines provided to the patient regarding their diet, medication use, and other activities in the days leading up to the surgery. These instructions may include fasting guidelines, discontinuing certain medications, or arranging for transportation after the procedure.
4. Anesthesia consultation: A meeting with the anesthesiologist to discuss the type of anesthesia that will be used during the surgery and address any concerns related to anesthesia risks, side effects, or postoperative pain management.
5. Preparation of the surgical site: Cleaning and shaving the area where the incision will be made, as well as administering appropriate antimicrobial agents to minimize the risk of infection.
6. Medical optimization: Addressing any underlying medical conditions or correcting abnormalities that may negatively impact the surgical outcome. This may involve adjusting medications, treating infections, or managing chronic diseases such as diabetes.
7. Emotional and psychological support: Providing counseling, reassurance, and education to help alleviate anxiety, fear, or emotional distress related to the surgery.
8. Preoperative holding area: The patient is transferred to a designated area near the operating room where they are prepared for surgery by changing into a gown, having intravenous (IV) lines inserted, and receiving monitoring equipment.

By following these preoperative care guidelines, healthcare professionals aim to ensure that patients undergo safe and successful surgical procedures with optimal outcomes.

Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.

Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.

It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.

A "false negative" reaction in medical testing refers to a situation where a diagnostic test incorrectly indicates the absence of a specific condition or disease, when in fact it is present. This can occur due to various reasons such as issues with the sensitivity of the test, improper sample collection, or specimen handling and storage.

False negative results can have serious consequences, as they may lead to delayed treatment, misdiagnosis, or a false sense of security for the patient. Therefore, it is essential to interpret medical test results in conjunction with other clinical findings, patient history, and physical examination. In some cases, repeating the test or using a different diagnostic method may be necessary to confirm the initial result.

Breast neoplasms refer to abnormal growths in the breast tissue that can be benign or malignant. Benign breast neoplasms are non-cancerous tumors or growths, while malignant breast neoplasms are cancerous tumors that can invade surrounding tissues and spread to other parts of the body.

Breast neoplasms can arise from different types of cells in the breast, including milk ducts, milk sacs (lobules), or connective tissue. The most common type of breast cancer is ductal carcinoma, which starts in the milk ducts and can spread to other parts of the breast and nearby structures.

Breast neoplasms are usually detected through screening methods such as mammography, ultrasound, or MRI, or through self-examination or clinical examination. Treatment options for breast neoplasms depend on several factors, including the type and stage of the tumor, the patient's age and overall health, and personal preferences. Treatment may include surgery, radiation therapy, chemotherapy, hormone therapy, or targeted therapy.

Indocyanine green (ICG) is a sterile, water-soluble, tricarbocyanine dye that is used as a diagnostic agent in medical imaging. It is primarily used in ophthalmology for fluorescein angiography to examine blood flow in the retina and choroid, and in cardiac surgery to assess cardiac output and perfusion. When injected into the body, ICG binds to plasma proteins and fluoresces when exposed to near-infrared light, allowing for visualization of various tissues and structures. It is excreted primarily by the liver and has a half-life of approximately 3-4 minutes in the bloodstream.

Organotechnetium compounds are chemical substances that contain carbon-technetium bonds, where technetium is an element with the symbol Tc and atomic number 43. These types of compounds are primarily used in medical imaging as radioactive tracers due to the ability of technetium-99m to emit gamma rays. The organotechnetium compounds help in localizing specific organs, tissues, or functions within the body, making them useful for diagnostic purposes in nuclear medicine.

It is important to note that most organotechnetium compounds are synthesized from technetium-99m, which is generated from the decay of molybdenum-99. The use of these compounds requires proper handling and administration by trained medical professionals due to their radioactive nature.

I'm sorry for any confusion, but "Rhenium" is not a medical term. It is a chemical element with the symbol "Re" and atomic number 75. Rhenium is a heavy, silvery-white, metallic element that is highly resistant to corrosion and is used in high-temperature alloys and electronics.

It does not have any direct medical relevance or application as a drug, treatment, or diagnostic tool in human medicine. However, like many other elements, rhenium compounds are being studied for their potential medicinal uses, such as in cancer therapy. But it's important to note that these are still in the research phase and have not yet been approved for use in humans.

Coloring agents, also known as food dyes or color additives, are substances that are added to foods, medications, and cosmetics to improve their appearance by giving them a specific color. These agents can be made from both synthetic and natural sources. They must be approved by regulatory agencies such as the U.S. Food and Drug Administration (FDA) before they can be used in products intended for human consumption.

Coloring agents are used for various reasons, including:

* To replace color lost during food processing or preparation
* To make foods more visually appealing
* To help consumers easily identify certain types of food
* To indicate the flavor of a product (e.g., fruit-flavored candies)

It's important to note that while coloring agents can enhance the appearance of products, they do not affect their taste or nutritional value. Some people may have allergic reactions to certain coloring agents, so it's essential to check product labels if you have any known allergies. Additionally, excessive consumption of some synthetic coloring agents has been linked to health concerns, so moderation is key.

The intraoperative period is the phase of surgical treatment that refers to the time during which the surgery is being performed. It begins when the anesthesia is administered and the patient is prepared for the operation, and it ends when the surgery is completed, the anesthesia is discontinued, and the patient is transferred to the recovery room or intensive care unit (ICU).

During the intraoperative period, the surgical team, including surgeons, anesthesiologists, nurses, and other healthcare professionals, work together to carry out the surgical procedure safely and effectively. The anesthesiologist monitors the patient's vital signs, such as heart rate, blood pressure, oxygen saturation, and body temperature, throughout the surgery to ensure that the patient remains stable and does not experience any complications.

The surgeon performs the operation, using various surgical techniques and instruments to achieve the desired outcome. The surgical team also takes measures to prevent infection, control bleeding, and manage pain during and after the surgery.

Overall, the intraoperative period is a critical phase of surgical treatment that requires close collaboration and communication among members of the healthcare team to ensure the best possible outcomes for the patient.

The pelvis is the lower part of the trunk, located between the abdomen and the lower limbs. It is formed by the fusion of several bones: the ilium, ischium, and pubis (which together form the hip bone on each side), and the sacrum and coccyx in the back. The pelvis has several functions including supporting the weight of the upper body when sitting, protecting the lower abdominal organs, and providing attachment for muscles that enable movement of the lower limbs. In addition, it serves as a bony canal through which the reproductive and digestive tracts pass. The pelvic cavity contains several vital organs such as the bladder, parts of the large intestine, and in females, the uterus, ovaries, and fallopian tubes.

Lymphatic vessels are thin-walled, valved structures that collect and transport lymph, a fluid derived from the interstitial fluid surrounding the cells, throughout the lymphatic system. They play a crucial role in immune function and maintaining fluid balance in the body. The primary function of lymphatic vessels is to return excess interstitial fluid, proteins, waste products, and immune cells to the bloodstream via the subclavian veins near the heart.

There are two types of lymphatic vessels:

1. Lymphatic capillaries: These are the smallest lymphatic vessels, found in most body tissues except for the central nervous system (CNS). They have blind ends and are highly permeable to allow the entry of interstitial fluid, proteins, and other large molecules.
2. Larger lymphatic vessels: These include precollecting vessels, collecting vessels, and lymphatic trunks. Precollecting vessels have valves that prevent backflow of lymph and merge to form larger collecting vessels. Collecting vessels contain smooth muscle in their walls, which helps to propel the lymph forward. They also have valves at regular intervals to ensure unidirectional flow towards the heart. Lymphatic trunks are large vessels that collect lymph from various regions of the body and eventually drain into the two main lymphatic ducts: the thoracic duct and the right lymphatic duct.

Overall, lymphatic vessels play a vital role in maintaining fluid balance, immune surveillance, and waste removal in the human body.

Carcinoma, ductal refers to a type of cancer that begins in the milk ducts (tubes that carry milk from the breast to the nipple). It is most commonly found in the breast and is often referred to as "invasive ductal carcinoma" when it has spread beyond the ducts into the surrounding breast tissue. Ductal carcinoma can also occur in other organs, such as the pancreas, where it is called "pancreatic ductal adenocarcinoma." This type of cancer is usually aggressive and can metastasize (spread) to other parts of the body.

Dextrans are a type of complex glucose polymers that are formed by the action of certain bacteria on sucrose. They are branched polysaccharides consisting of linear chains of α-1,6 linked D-glucopyranosyl units with occasional α-1,3 branches.

Dextrans have a wide range of applications in medicine and industry. In medicine, dextrans are used as plasma substitutes, volume expanders, and anticoagulants. They are also used as carriers for drugs and diagnostic agents, and in the manufacture of immunoadsorbents for the removal of toxins and pathogens from blood.

Dextrans can be derived from various bacterial sources, but the most common commercial source is Leuconostoc mesenteroides B-512(F) or L. dextranicum. The molecular weight of dextrans can vary widely, ranging from a few thousand to several million Daltons, depending on the method of preparation and purification.

Dextrans are generally biocompatible and non-toxic, but they can cause allergic reactions in some individuals. Therefore, their use as medical products requires careful monitoring and testing for safety and efficacy.

Carcinoma, lobular is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It can be either invasive or non-invasive (in situ). Invasive lobular carcinoma (ILC) occurs when the cancer cells break through the wall of the lobule and invade the surrounding breast tissue, and can potentially spread to other parts of the body. Non-invasive lobular carcinoma (LCIS), on the other hand, refers to the presence of abnormal cells within the lobule that have not invaded nearby breast tissue.

ILC is usually detected as a mass or thickening in the breast, and it may not cause any symptoms or show up on mammograms until it has grown quite large. It tends to grow more slowly than some other types of breast cancer, but it can still be serious and require extensive treatment. LCIS does not typically cause any symptoms and is usually found during a biopsy performed for another reason.

Treatment options for carcinoma, lobular depend on several factors, including the stage of the cancer, the patient's overall health, and their personal preferences. Treatment may include surgery, radiation therapy, chemotherapy, hormone therapy, or targeted therapy. Regular follow-up care is essential to monitor for recurrence or the development of new cancers.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

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Another, more commonly used type of lymphogram is nuclear lymphoscintigraphy; this procedure requires human pentetic acid ...
Villa, G.; Campisi, C. C. (2019). "Procedural Recommendations for Lymphoscintigraphy in the Diagnosis of Peripheral Lymphedema ... "Rationale for Study of the Deep Subfascial Lymphatic Vessels During Lymphoscintigraphy for the Diagnosis of Peripheral ...
It is sometimes diagnosed prenatally by a nuchal scan or postnatally by lymphoscintigraphy.[medical citation needed] The most ... Imaging studies such as lymphoscintigraphy and indocyanine green lymphography are only required when surgery is being ...
"Effect of Lymphoscintigraphy Drainage Patterns on Sentinel Lymph Node Biopsy in Patients with Breast Cancer", Am. J. Surg., ... 2005). "Effect of lymphoscintigraphy drainage patterns on sentinel lymph node biopsy in patients with breast cancer". Am J Surg ...
"89Zr-Nanocolloidal Albumin-Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical ...
Scintigraphy of lymph flow (lymphoscintigraphy) shows delays in drainage of lymph (sometimes asymmetrically), although this ...
A process called lymphoscintigraphy is performed in which a radioactive tracer is injected at the tumor site to localize the ...
... with particular reference to the best use of Lymphoscintigraphy diagnostics for the study of lymphatic insufficiency of the ...
... lymphoscintigraphy for sentinel lymph node biopsy, parathyroid imaging for hyperparathyroidism, pulmonary perfusion and ...
... lymphoscintigraphy - Lynch syndrome - lysis - lysosome - lytic - lytic lesion M protein - macroglobulinemia - macrophage - ...
Background Lymphoscintigraphy (sentinel lymph node mapping) is an imaging technique used to identify the lymph drainage basin, ... Breast Cancer Lymphoscintigraphy (Sentinel Lymph Node Mapping) * Sections Breast Cancer Lymphoscintigraphy (Sentinel Lymph Node ... encoded search term (Breast Cancer Lymphoscintigraphy (Sentinel Lymph Node Mapping)) and Breast Cancer Lymphoscintigraphy ( ... Breast Cancer Lymphoscintigraphy (Sentinel Lymph Node Mapping) Updated: Nov 15, 2022 * Author: Durre Sabih, MBBS, MSc, FRCP( ...
Stress Lymphoscintigraphy.. Lymphoscintigraphy can be performed after an intervention designed to augment lymphatic flow-such ... Clinical Applications of Extremity Lymphoscintigraphy. Differential Diagnosis of Extremity Edema.. Lymphoscintigraphy offers ... Ter SE, Alavi A, Kim CK, Merli G. Lymphoscintigraphy: a reliable test for the diagnosis of lymphedema. Clin Nucl Med. 1993;18: ... The Third Circulation: Radionuclide Lymphoscintigraphy in the Evaluation of Lymphedema. Andrzej Szuba, William S. Shin, H. ...
Lymphoscintigraphy for the Assessment of Autologous Stem Cell Implantation in Chronic Lymphedema.. Quián YPeña, Ramirez ... Lymphoscintigraphy for the Assessment of Autologous Stem Cell Implantation in Chronic Lymphedema. Clin Nucl Med. 2014. ...
Lymphoscintigraphy in patients with non-extremity lymphedema following axilla dissection and radiotherapy .. * Authors: Hana ... Authors of this article have focused on the evaluation of the benefit of lymphoscintigraphy in patients with suspect non- ... Lymphoscintigraphy in patients with non-extremity lymphedema following axilla dissection and radiotherapy . ... Besides breast lymphedema imaging, the lymphoscintigraphy enables to depict alternative lymphatic routes which drain to other ...
The lymphoscintigraphy sounds scarier than the actual surgery to me, the surgeon looked me right in the eye and said it would ... The lymphoscintigraphy sounds scarier than the actual surgery to me, the surgeon looked me right in the eye and said it would ... I had my lymphoscintigraphy this morning. Mine didnt hurt anymore than my monthly allergy shot. It may have been because the ... I had my lymphoscintigraphy this morning. Mine didnt hurt anymore than my monthly allergy shot. It may have been because the ...
Lymphoscintigraphy is a diagnostic imaging method that uses tracers labeled with radioactive isotopes to study lymphatic ... Lymphoscintigraphy. Nuclear Medicine studies (scintigraphy) are methods of Diagnostic Imaging that use radioactive isotopes. ...
Lymphoscintigraphy. As mentioned earlier, the most commonly used modality is lymphoscintigraphy, in which a radioactive tracer ... Lymphoscintigraphy is also useful for obtaining a precise determination of the pattern of lymphatic drainage. SLNs can be ... Identification of the sentinel lymph node (SLN) is usually achieved by means of both lymphoscintigraphy and the injection of a ...
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Lymphoscintigraphy in experimental maligant ascites Bloomer, W.D.; Adelstein, S.J.; Harvard Medical School, Boston, MA; Harvard ...
Lymphoscintigraphy. Description This imaging option shows how fluid moves through the lymphatic system over time. Although it ... Before surgery, you may need to undergo a special type of imaging called lymphoscintigraphy. It helps your surgeon map out your ...
Preoperative planar lymphoscintigraphy Preoperative planar lymphoscintigraphy in conjunction with SPECT/CT [single ... BNMS (August 2011). "Lymphoscintigraphy Clinical Guidelines" (PDF). Retrieved 3 January 2017. Tanis PJ, Boom RP, Koops HS, ... To perform a sentinel lymph node biopsy, the physician performs a lymphoscintigraphy, wherein a low-activity radioactive ...
Lymphoscintigraphy was performed with 99 m-Tc sulfur colloid which showed tracer accumulation into thoracic cavity, and single- ... We, thus, emphasize the role of lymphoscintigraphy with SPECT/CT in identification of cause and guiding the management of ... Small Chyle Leak Localized on Lymphoscintigraphy with Single-Photon Emission Computed Tomography-Computed Tomography.. Parneet ...
Lymphoscintigraphy (American College of Radiology; Radiological Society of North America) Also in Spanish ...
30 minutes post radiotracer injection static lymphoscintigraphy images were acquired using low energy high resolution ... a method for outlining the body during lymphoscintigraphy without using external flood source Background. We evaluated the ... Lymphoscintigraphy with double tracer technique in carcinomas of the head-neck region]. Laryngo- rhino- otologie, 76 12 ... Static lymphoscintigraphy images were acquired 30 minutes post-injection using a dual head variable angle gamma camera (E.CAM ...
Lymphoscintigraphy: radiopharmaceutical selection and methods. Kramer EL. Kramer EL. Int J Rad Appl Instrum B. 1990;17(1):57-63 ... Lymphoscintigraphy: defining a clinical role. Kramer EL. Kramer EL. Lymphat Res Biol. 2004;2(1):32-7. doi: 10.1089/ ...
Vapocoolant Analgesia for Breast Lymphoscintigraphy. NCT04768426. Serial Circulating Tumor DNA (ctDNA) Monitoring During ...
Lymphoscintigraphy * Mammogram * Modified Barium Swallow * Pelvic Us Obstetric * Small Bowel Follow Through ...
Essner R: The role of lymphoscintigraphy and sentinel node mapping in assessing patient risk in melanoma. Semin Oncol 24 (1 ... Uren RF, Howman-Giles R, Thompson JF, et al.: Lymphoscintigraphy to identify sentinel lymph nodes in patients with melanoma. ...
Lymphoscintigraphy in unilateral lower limb and scrotal lymphedema caused by filariasis. Am J Trop Med Hyg. 2012 Dec. 87(6):963 ...
Moshiri M, Katz DS, Boris M, Yung E (2002) Using lymphoscintigraphy to evaluate suspected lymphedema of the extremities. AJR Am ... Weissleder H, Weissleder R (1988) Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients. ...
Lymphoscintigraphy. *Meckels scan for Meckels diverticulum. *Myocardial perfusion scan. *Parathyroid SPECT/CT scan ...
This imaging study is called lymphoscintigraphy). The surgeon removes the sentinel node(s) to check for cancer cells. ...
... assessment with use of lymphoscintigraphy. Clin Infect Dis1996;23:1007-11. doi:10.1093/clinids/23.5.1007 pmid:8922794. ...
Neither lymphoscintigraphy nor intraoperative blue-dye sentinel-node biopsy (eg, selective neck dissection) is useful in ... Sentinel-node biopsy or lymphoscintigraphy, which is beneficial in staging of cutaneous melanoma, has less value in staging or ...
Ultrasound and lymphoscintigraphy can be used to detect presence of motile adult worms in lymphatic vessels, known as filarial ...
Lymphoscintigraphy is a test that involves injecting a tracer dye into lymph vessels and then observing the flow of fluid using ...
EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma (2015). in cooperation with the ... The EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers ( ... EANM/SNMMI practice guideline for lymphoscintigraphy and sentinel node localization in breast cancer (2013) ...
From the site of the metastasis on the right scapular region, lymphoscintigraphy with axillary sentinel lymph node biopsy was ...
The addition of SPECT/CT lymphoscintigraphy to breast cancer radiation planning spares lymph nodes critical for arm drainage. ...

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