An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.
A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).
Pathological processes involving any part of the LUNG.
A condition caused by an apical lung tumor (Pancoast tumor) with involvement of the nearby vertebral column and the BRACHIAL PLEXUS. Symptoms include pain in the shoulder and the arm, and atrophy of the hand.
A condition that is characterized by inflammation, ulceration, and perforation of the nose and the PALATE with progressive destruction of midline facial structures. This syndrome can be manifested in several diseases including the nasal type of EXTRANODAL NK-T-CELL LYMPHOMA and GRANULOMATOSIS WITH POLYANGIITIS.
A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.

Lymphomatoid granulomatosis following autologous stem cell transplantation. (1/49)

Lymphomatoid granulomatosis (LYG) is a rare angio-destructive lymphoproliferative disorder (LPD) of uncertain etiology, with prominent pulmonary involvement. Recent studies indicate that LYG is an Epstein-Barr virus (EBV)-associated B cell LPD with large numbers of background reactive T lymphocytes (T cell-rich B cell lymphoma). Although the disease frequently, but not exclusively, occurs in various immunodeficiency states, it has not been reported in association with the transient immunosuppression following autologous bone marrow/peripheral stem cell transplantation (ABM/PSCT). We describe a patient who developed lymphomatoid granulomatosis of the lung approximately 2 weeks after high-dose chemotherapy and autologous peripheral stem cell transplantation for multiple myeloma. Although molecular studies showed no evidence of EBV genome in the biopsy material, the serologic profile with high IgM titers was suggestive of primary EBV infection. Complete radiologic remission occurred following reconstitution of the patient's immune response after a 2-week course of ganciclovir treatment. Despite the apparently low frequency of LPD (both LYG and EBV-associated post-transplant lymphoma) in the ABMT setting, we believe that it should be considered in the differential diagnosis of patients whose clinical course following ABMT is complicated by fevers, in the absence of an identifiable infectious process.  (+info)

Expression of thioredoxin in granulomas of sarcoidosis: possible role in the development of T lymphocyte activation. (2/49)

BACKGROUND: Activated T lymphocytes are one of the characteristic features of sarcoidosis. The mechanism of T cell activation, expressing various activation markers including interleukin 2 receptor (IL-2R), has been extensively investigated but the precise mechanism remains unknown. Although thioredoxin (TRX) displays a number of biological activities including IL-2R inducing activity, its role in the induction of IL-2R expression on T cells in sarcoidosis has not been determined. The expression of TRX and IL-2R in granulomas of patients with sarcoidosis has been studied to clarify a possible role for TRX in the induction of IL-2R expression. METHODS: Granulomas in specimens of lung tissue and lymph nodes from five patients with sarcoidosis were immunohistochemically stained with anti-TRX antibody and anti-IL-2Ralpha chain antibody and the concentration of TRX in the bronchoalveolar lavage (BAL) fluid from 20 patients with pulmonary sarcoidosis was measured. RESULTS: Granulomas in lung and lymph node tissue from patients with sarcoidosis showed strong reactivity with anti-TRX antibody. Positive staining was present in the macrophages, epithelioid cells, and Langhans' type giant cells but not in lymphocytes. IL-2R was expressed on lymphocytes in the same granulomas. By contrast, positive immunoreactivity was not found in lung tissue specimens from 12 control subjects. Concentrations of TRX in BAL fluid were higher in patients with pulmonary sarcoidosis (median (range) 122.6 (20.9-303.3) ng/ml) than in control subjects (32.9 (16.8-52.8) ng/ml, p<0.05). CONCLUSIONS: TRX is highly expressed and is locally produced by granulomas in patients with sarcoidosis. The coexistence of immunoreactive TRX and IL-2R in the same granulomas suggests that TRX might act as a local inducing factor for IL-2R expression on T cells.  (+info)

Pulmonary lymphomatoid granulomatosis in a cat. (3/49)

Pulmonary lymphomatoid granulomatosis was diagnosed in a 9-year-old castrated male domestic shorthair cat with a history of coughing, lethargy, and anorexia. Radiographic examination revealed multiple pulmonary opacities, consolidation of left lung lobes, and enlarged tracheobronchial lymph nodes. Cytologic examination of impression smears of abnormal pulmonary tissue revealed erythrocytes, lymphocytes, and macrophages, with scattered atypical lymphocytes and binucleate cells. Histopathologic evaluation of abnormal lung tissue revealed multiple, coalescing, densely cellular nodules composed of anaplastic and pleomorphic lymphocytes, with scattered binucleate and multinucleate cells. Marked infiltration and effacement of bronchiolar and vascular smooth muscle were present. These features are characteristic of lymphomatoid granulomatosis. To the authors' knowledge, this is the first report of pulmonary lymphomatoid granulomatosis in a cat.  (+info)

MR imaging of the brain in lymphomatoid granulomatosis. (4/49)

BACKGROUND AND PURPOSE: Clinical diagnosis of lymphomatoid granulomatosis (LG) of the brain, in patients without skin or chest lesions, usually is difficult because of the nonspecific neurologic manifestations, laboratory data, and CT appearance. Our aim was to characterize the MR appearance of LG of the brain. METHODS: We retrospectively reviewed the MR images in four patients (35 to 72 years old) with histologically confirmed LG of the brain. RESULTS: On T2-weighted images, we noted diffuse hyperintense lesions in the cerebral white matter bilaterally (n = 3), in the brain stem and cerebellar hemisphere (n = 1), and patchy hyperintense lesions the brain stem (n = 2). On contrast-enhanced T1-weighted images, we observed multiple punctate or linear enhancements residing along the perivascular space (n = 4), nodular enhancements (n = 2), ringlike enhancements (n = 1), and a large, enhanced mass (n = 1). All patients had multifocal lesions. CONCLUSION: Although the MR appearance of LG of the brain varies, multiple punctate or linear enhancements that reside along the perivascular space suggest LG.  (+info)

Expression of cytolytic lymphocyte-associated antigens in pulmonary lymphomatoid granulomatosis. (5/49)

Paraffin-embedded lung wedge biopsy specimens from 14 patients with pulmonary lymphomatoid granulomatosis (LYG) were analyzed using immunoperoxidase stains specific for T cell- and natural killer cell-associated antigens. Nine cases had a minor population of CD20+ large B-cells (B-cell LYG) amidst a background of CD3- and betaF1-immunoreactive T cells. In 8 of the 9 B-cell LYG cases, the majority of the background T lymphocytes had a cytotoxic phenotype as defined by the expression of CD8 and the cytotoxic granule proteins TIA-1 (granule membrane protein 17) and granzyme B. Five cases lacked CD20+ large cells and, instead, showed predominantly CD3+ and betaF1 + T cells (T-cell LYG). Whereas the small, medium, and large atypical lymphocytes were all positive for CD3 and betaF1 in the T-cell LYG cases, immunoreactivity for CD8, TIA-1, and granzyme B was limited to the small lymphocytes, with a distribution indistinguishable from that seen in B-cell LYG. These findings indicate that LYG is composed of a heterogeneous group of lymphoproliferative disorders that share, as unifying features, a relative paucity of neoplastic cells and a prominent reactive infiltrate rich in cytolytic lymphocytes.  (+info)

Primary pulmonary lymphoma. (6/49)

Three distinct entities are now covered by the definition of primary pulmonary clonal lymphoid proliferation. The aim of this review is to describe the pathophysiological, diagnostic, prognostic and therapeutic aspects of these three entities. Low-grade pulmonary B-cell lymphoma is the most frequent form of primary pulmonary clonal lymphoid proliferation. It arises from mucosa-associated lymphoid tissue. It is usually indolent and appears in the form of a chronic alveolar opacity. The prognosis is excellent, but treatment is controversial (simple monitoring, surgery or single-agent chemotherapy). High-grade pulmonary B-cell lymphoma is far rarer and usually occurs in individuals with an underlying disorder (e.g. immunodeficiency). The prognosis is poor and therapeutic options depend on the underlying disorder. The inclusion of lymphomatoid granulomatosis in the definition of primary pulmonary lymphomas is controversial. The clonal nature of the proliferation is very rarely demonstrated and extrapulmonary involvement is frequent (upper airways, skin, kidneys, central nervous system, etc.). The prognosis is extremely variable, with some authors reporting complete remission with steroids and cyclophosphamide and others reporting failure of combination chemotherapy.  (+info)

Pulmonary lymphomatoid granulomatosis evolving to large cell lymphoma in the skin. (7/49)

Lymphomatoid granulomatosis is an angiodestructive, angioinvasive lymphoproliferative disorder. It involves most frequently lungs, central nervous system and skin. Recent studies indicate that lymphomatoid granulomatosis is an Epstein-Barr virus associated B cell disorder with a background of reactive T lymphocytes. In a 49 year old woman presenting with fever, malaise and pulmonary masses the diagnosis of lymphomatoid granulomatosis was established histologically by open lung biopsy. Following the initial diagnosis the patient was found to have gastric and skin involvement. The skin lesion was diagnosed as diffuse large B-cell lymphoma.  (+info)

Isolated EBV lymphoproliferative disease in a child with Wiskott-Aldrich syndrome manifesting as cutaneous lymphomatoid granulomatosis and responsive to anti-CD20 immunotherapy. (8/49)

Patients with primary immunodeficiencies such as the Wiskott-Aldrich syndrome (WAS) are prone to develop Epstein-Barr virus (EBV) related lymphoproliferative disorders (LPDs). EBV LPD is most frequently seen in patients receiving immunosuppressive treatment after organ transplantation (post-transplant lymphoproliferative disorder), but can also arise in the primary immunodeficiencies. Typically, EBV LPD presents as a diffuse systemic disease with lymphadenopathy and organ involvement. A rare angiocentric and angiodestructive form of EBV associated B cell LPD, lymphomatoid granulomatosis (LyG), has also been reported in association with WAS. LyG most commonly involves the lung, but can also be seen in brain, kidney, liver, and skin. This report describes the case of a 16 year old boy with WAS who presented with an isolated non-healing ulcerating skin lesion. Biopsy revealed an EBV related LPD with the histological features of LyG. This cutaneous lesion responded dramatically to treatment with specific anti-CD20 immunotherapy and the patient remains clinically free of LPD at 18 months.  (+info)

Lymphomatoid Granulomatosis is a rare, progressive and potentially fatal inflammatory disorder characterized by the proliferation of atypical B-lymphocytes infiltrating the lungs, skin, and less frequently other organs. It is considered an angiocentric and angiodestructive lymphoproliferative disease with varying degrees of malignancy. The condition is often associated with Epstein-Barr virus (EBV) infection and is more prevalent in middle-aged men.

The disorder presents with a wide range of symptoms, depending on the affected organs. Lung involvement can cause cough, shortness of breath, chest pain, or hemoptysis, while skin manifestations may include papules, nodules, or ulcers. Other possible sites of involvement are the central nervous system, kidneys, and liver.

Lymphomatoid Granulomatosis is classified into three grades based on the number of atypical lymphocytes and degree of necrosis: grade I (few atypical cells, minimal necrosis), grade II (more atypical cells, mild to moderate necrosis), and grade III (large numbers of atypical cells, extensive necrosis). Grades II and III are considered high-grade lymphomas.

The diagnosis is established through a combination of clinical presentation, radiological findings, and histopathological examination of biopsy specimens. Treatment options include corticosteroids, chemotherapy, immunomodulatory agents, and radiation therapy. The prognosis varies depending on the grade, extent of disease, and response to treatment.

Wegener Granulomatosis is a rare, chronic granulomatous vasculitis that affects small and medium-sized blood vessels. It is also known as granulomatosis with polyangiitis (GPA). The disease primarily involves the respiratory tract (nose, sinuses, trachea, and lungs) and kidneys but can affect other organs as well.

The characteristic features of Wegener Granulomatosis include necrotizing granulomas, vasculitis, and inflammation of the blood vessel walls. These abnormalities can lead to various symptoms such as cough, shortness of breath, nosebleeds, sinus congestion, skin lesions, joint pain, and kidney problems.

The exact cause of Wegener Granulomatosis is unknown, but it is believed to be an autoimmune disorder where the body's immune system mistakenly attacks its own tissues and organs. The diagnosis of Wegener Granulomatosis typically involves a combination of clinical symptoms, laboratory tests, imaging studies, and biopsy findings. Treatment usually includes immunosuppressive therapy to control the inflammation and prevent further damage to the affected organs.

Lung diseases refer to a broad category of disorders that affect the lungs and other structures within the respiratory system. These diseases can impair lung function, leading to symptoms such as coughing, shortness of breath, chest pain, and wheezing. They can be categorized into several types based on the underlying cause and nature of the disease process. Some common examples include:

1. Obstructive lung diseases: These are characterized by narrowing or blockage of the airways, making it difficult to breathe out. Examples include chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, and cystic fibrosis.
2. Restrictive lung diseases: These involve stiffening or scarring of the lungs, which reduces their ability to expand and take in air. Examples include idiopathic pulmonary fibrosis, sarcoidosis, and asbestosis.
3. Infectious lung diseases: These are caused by bacteria, viruses, fungi, or parasites that infect the lungs. Examples include pneumonia, tuberculosis, and influenza.
4. Vascular lung diseases: These affect the blood vessels in the lungs, impairing oxygen exchange. Examples include pulmonary embolism, pulmonary hypertension, and chronic thromboembolic pulmonary hypertension (CTEPH).
5. Neoplastic lung diseases: These involve abnormal growth of cells within the lungs, leading to cancer. Examples include small cell lung cancer, non-small cell lung cancer, and mesothelioma.
6. Other lung diseases: These include interstitial lung diseases, pleural effusions, and rare disorders such as pulmonary alveolar proteinosis and lymphangioleiomyomatosis (LAM).

It is important to note that this list is not exhaustive, and there are many other conditions that can affect the lungs. Proper diagnosis and treatment of lung diseases require consultation with a healthcare professional, such as a pulmonologist or respiratory therapist.

Pancoast syndrome is a constellation of symptoms resulting from the invasion and compression of various neurological and vascular structures at the apex (top) of the lung, most commonly caused by a specific type of lung cancer known as Pancoast tumor or superior sulcus tumor. The syndrome is characterized by shoulder pain, Horner's syndrome (meiosis, ptosis, and anhidrosis), and weakness or atrophy of the hand muscles due to involvement of the lower brachial plexus.

A lethal midline granuloma (LMG) is a rare and aggressive form of necrotizing granulomatous inflammation that typically involves the nasopharynx, paranasal sinuses, and/or the central nervous system. It is called "lethal" because of its rapid progression and high mortality rate if left untreated.

LMG is a type of granuloma, which is a collection of immune cells that form in response to chronic inflammation or infection. In LMG, the granulomas are characterized by extensive necrosis (tissue death) and vasculitis (inflammation of blood vessels).

The exact cause of LMG is not fully understood, but it is believed to be associated with a variety of factors, including infections (such as fungal or mycobacterial infections), autoimmune disorders, and lymphoproliferative diseases. Treatment typically involves a combination of surgical debridement, antimicrobial therapy, and immunosuppressive drugs. Despite treatment, the prognosis for LMG is generally poor, with a high rate of recurrence and significant morbidity and mortality.

The Stellate Ganglion is a part of the sympathetic nervous system. It's a collection of nerve cells (a ganglion) located in the neck, more specifically at the level of the sixth and seventh cervical vertebrae. The stellate ganglion is formed by the fusion of the inferior cervical ganglion and the first thoracic ganglion.

This ganglion plays a crucial role in the body's "fight or flight" response, providing sympathetic innervation to the head, neck, upper extremities, and heart. It's responsible for various functions including regulation of blood flow, sweat gland activity, and contributing to the sensory innervation of the head and neck.

Stellate ganglion block is a medical procedure used to diagnose or treat certain conditions like pain disorders, by injecting local anesthetic near the stellate ganglion to numb the area and interrupt nerve signals.

... (LYG or LG) is a very rare lymphoproliferative disorder first characterized in 1972. Lymphomatoid ... Lymphomatoid granulomatosis involves malignant B cells and reactive, non-malignant T cells and is almost always associated with ... Boone, J. M.; Zhang, D; Fan, F (2013). "Lymphomatoid granulomatosis: A case report with unique clinical and histopathologic ... Barakat, Athar; Grover, Karan; Peshin, Rohit (2014). "Rituximab for pulmonary lymphomatoid granulomatosis which developed as a ...
EBV+ lymphomatoid granulomatosis (EBV+ LG, also termed lymphomatoid granulomatosis [LG]) is a rare disease that involves ... Roschewski M, Wilson WH (2012). "Lymphomatoid granulomatosis". Cancer Journal (Sudbury, Mass.). 18 (5): 469-74. doi:10.1097/PPO ... "Lymphomatoid granulomatosis: A case series from South India". Indian Journal of Pathology & Microbiology. 61 (2): 228-232. doi: ... "Lymphomatoid Granulomatosis: A Single Institution Experience and Review of the Literature". Clinical Lymphoma, Myeloma & ...
Katzenstein, A. L. A., Carrington, C. B., & Liebow, A. A. (1979). Lymphomatoid granulomatosis. A clinicopathologic study of 152 ... Liebow, A. A. (1972). Lymphomatoid granulomatosis. California medicine, 116(5), 48. Bahadori, M., & Liebow, A. A. (1973). ... lymphomatoid granulomatosis, pulmonary Langerhans cell histiocytosis, pulmonary epithelioid hemangioendothelioma and pulmonary ... Carrington, C. B., & Liebow, A. A. (1966). Limited forms of angiitis and granulomatosis of Wegener's type. The American journal ...
Sunderrajan, E V; Passamonte, PM (1984). "Lymphomatoid granulomatosis presenting as central neurogenic hyperventilation". Chest ...
Lymphomatoid granulomatosis (LYG) is a DLBCL in which large, atypical B-cells with immunoblastic or Hodgkin disease-like ... Lymphomatoid granulomatosis almost always involves the lung but may concurrently involve the brain, peripheral nervous system, ... "Lymphomatoid Granulomatosis: A Single Institution Experience and Review of the Literature". Clinical Lymphoma, Myeloma & ...
In 1979, Cignetti was diagnosed with lymphomatoid granulomatosis, a form of cancer. He had a splenectomy and spent 35 days in ...
August 2013). "Lymphomatoid granulomatosis: A practical review for pathologists dealing with this rare pulmonary ... and lymphomatoid granulomatosis. Specifically, EBV infected B cells have been shown to reside within the brain lesions of ...
The disease is still sometimes confused with lethal midline granuloma and lymphomatoid granulomatosis, both malignant lymphomas ... Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), after the Nazi German physician ... "Granulomatosis with polyangiitis (Wegener's): an alternative name for Wegener's granulomatosis". Annals of the Rheumatic ... leading to the eponymous name Wegener's granulomatosis or Wegener granulomatosis (English: /ˈvɛɡənər/). In 2011, the American ...
... and lymphomatoid granulomatosis. In a 1985 Stanford University Arthritis Center Survey, members of the American Rheumatism ... Wikidata () Fauci, Anthony S.; Haynes, Barton F.; Katz, Paul; Wolff, Sheldon M. (January 1983). "Wegener's Granulomatosis: ... He developed therapies for formerly fatal diseases such as polyarteritis nodosa, granulomatosis with polyangiitis, ... Association ranked Fauci's work on the treatment of polyarteritis nodosa and granulomatosis with polyangiitis as one of the ...
Leukemia cutis Lymphoma cutis Lymphomatoid granulomatosis Lymphomatoid papulosis Malignant histiocytosis (histiocytic medullary ... orofacial granulomatosis) Cutaneous sinus of dental origin (dental sinus) Cyclic neutropenia Desquamative gingivitis Drug- ... Granulomatosis with polyangiitis Harlequin color change Hematopoietic ulcer Hennekam syndrome (Hennekam lymphangiectasia- ... Eosinophilic granuloma Eosinophilic granulomatosis with polyangiitis Eosinophilic pustular folliculitis of infancy ( ...
2 Lymphomatoid granulomatosis, grade 3 Primary mediastinal (thymic) large B-cell lymphoma Intravascular large B-cell lymphoma ... ulcer DLBCL associated with chronic inflammation Fibrin-associated diffuse large B-cell lymphoma Lymphomatoid granulomatosis, ... lymphoma Mycosis fungoides Sézary syndrome Primary cutaneous CD30-positive T-cell lymphoproliferative disorders Lymphomatoid ...
... lymphoma Intravascular NK-cell lymphoma Intravascular T-cell lymphoma Primary effusion lymphoma Lymphomatoid granulomatosis ...
... diffuse large B-cell lymphoma of the CNS 9.1.1.2 Immunodeficiency-associated CNS lymphoma 9.1.1.3 Lymphomatoid granulomatosis ...
Intravascular large B-cell lymphoma Large granular lymphocytic leukemia Lymphoplasmacytic lymphoma Lymphomatoid granulomatosis ...
Angiocentric immunoproliferative lesion LYmphoid granulomatosis Lymphomatoid granulomatosis M9767/1 Angioimmunoblastic ... Lymphomatoid papulosis Primary cutaneous anaplastic large cell lymphoma Primary cutaneous CD30+ large T-cell lymphoma M9719/3 ... unifocal Langerhans cell granulomatosis, unifocal Langerhans cell histiocytosis, mono-ostotic Eosinophilic granuloma M9753/1 ...
... as well as in granulomatosis with polyangiitis, lymphomatoid granulomatosis, and sarcoidosis. CT showing diffuse ground-glass ... This may coexist with granulomatosis with polyangiitis, leading to diffuse areas of increased attenuation with ground-glass ... Important non-infectious causes include granulomatosis with polyangiitis, metastatic disease with pulmonary hemorrhage, and ... pneumonia Cholesterol granulomas Focal interstitial fibrosis Granulomatosis with polyangiitis Lymphatoid granulomatosis ...
... lymphomatoid granulomatosis - lymphoproliferative disorder - lymphosarcoma - lymphoscintigraphy - Lynch syndrome - lysis - ...
... follicular Lymphoma Lymphomatoid granulomatosis Lymphomatoid Papulosis (LyP) Lymphomatous thyroiditis Lymphosarcoma Lynch-Lee- ... Murday syndrome Lynch-Bushby syndrome Lyngstadaas syndrome LyP (lymphomatoid papulosis) Lysine alpha-ketoglutarate reductase ... Landy-Donnai syndrome Langdon Down Langer-Nishino-Yamaguchi syndrome Langer-Giedion syndrome Langerhans cell granulomatosis ...
Polyarteritis nodosa Granulomatosis with polyangiitis Behçet's disease Lymphomatoid granulomatosis Vasculitis Currently, there ...
... lymphomatoid granulomatosis MeSH C15.604.515.700 - marek disease MeSH C15.604.515.827 - sarcoidosis MeSH C15.604.515.827.725 - ...
... not otherwise specified Lymphomatoid granulomatosis Primary mediastinal (thymic) large B-cell lymphoma Intravascular large B- ... and lymphomatoid gastropathy, a disease wherein these cells' infiltrative lesions are limited to the stomach. These diseases do ... cutaneous CD30-positive T cell lymphoproliferative disorders Primary cutaneous anaplastic large cell lymphoma Lymphomatoid ...
... congenital cerebral Granulomatosis, lymphomatoid Granulomatous allergic angiitis Granulomatous hypophysitis Granulomatous ...
Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized in 1972. Lymphomatoid ... Lymphomatoid granulomatosis involves malignant B cells and reactive, non-malignant T cells and is almost always associated with ... Boone, J. M.; Zhang, D; Fan, F (2013). "Lymphomatoid granulomatosis: A case report with unique clinical and histopathologic ... Barakat, Athar; Grover, Karan; Peshin, Rohit (2014). "Rituximab for pulmonary lymphomatoid granulomatosis which developed as a ...
Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus -associated systemic angiodestructive lymphoproliferative ... encoded search term (Lymphomatoid Granulomatosis) and Lymphomatoid Granulomatosis What to Read Next on Medscape ... The pathogenesis of lymphomatoid granulomatosis is unknown; however, there is overwhelming evidence that lymphomatoid ... Lymphomatoid Granulomatosis. Updated: Jan 03, 2023 * Author: Nazir A Lone, MD, MBBS, MPH, FACP, FCCP; Chief Editor: Zab ...
Jaffre S, Jardin F, Dominique S, Duet E, Hubscher P, Genevois A, Fatal haemoptysis in a case of lymphomatoid granulomatosis ... Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med. 1982;306:68-74. DOI ... Lymphomatoid granulomatosis: a clinicopathologic study of 42 patients. Pathology. 1986;18:283-8. DOIPubMedGoogle Scholar ... Lymphomatoid granulomatosis. Hum Pathol. 1972;3:457-558. DOIPubMedGoogle Scholar ...
"Lymphomatoid Granulomatosis" by people in this website by year, and whether "Lymphomatoid Granulomatosis" was a major or minor ... "Lymphomatoid Granulomatosis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Rao R, Vugman G, Leslie WT, Loew J, Venugopal P. Lymphomatoid granulomatosis treated with rituximab and chemotherapy. Clin Adv ... Below are the most recent publications written about "Lymphomatoid Granulomatosis" by people in Profiles. ...
what is Lymphomatoid Granulomatosis? Symptoms, Treatment what is Lymphomatoid Granulomatosis? Lymphomatoid granulomatosis (LYG ...
Lymphomatoid granulomatosis: A clinicopathologic study of 42 patients. Michael N. Koss, Liselotte Hochholzer*, John M. Langloss ... Lymphomatoid granulomatosis : A clinicopathologic study of 42 patients. In: Pathology. 1986 ; Vol. 18, No. 3. pp. 283-288. ... Lymphomatoid granulomatosis: A clinicopathologic study of 42 patients. Pathology. 1986 Jul;18(3):283-288. doi: 10.3109/ ... title = "Lymphomatoid granulomatosis: A clinicopathologic study of 42 patients",. abstract = "We studied the histological and ...
Possible relationship of lymphomatoid granulomatosis and EBV infection. Clinical Immunology and Immunopathology, 41(3), 479-484 ... Possible relationship of lymphomatoid granulomatosis and EBV infection, Clinical Immunology and Immunopathology, vol. 41, no. ... Possible relationship of lymphomatoid granulomatosis and EBV infection. In: Clinical Immunology and Immunopathology. 1986 ; Vol ... Possible relationship of lymphomatoid granulomatosis and EBV infection. Together they form a unique fingerprint. ...
This study will evaluate the response and long-term effects of alpha-interferon in patients with lymphomatoid granulomatosis ( ... Lymphomatoid granulomatosis (LYG) is an angiocentric destructive proliferation of lymphoid cells predominantly involving the ... To determine the response and long-term efficacy of alpha-Interferon in patients with lymphomatoid granulomatosis (LYG).. To ... This study will evaluate the response and long-term effects of alpha-interferon in patients with lymphomatoid granulomatosis ( ...
Lymphomatoid granulomatosis * Primary mediastinal (thymic) large B-cell lymphoma * Intravascular large B-cell lymphoma ...
Lymphomatoid granulomatosis * Vascular aneurysms * Amyloid nodules * Cervical rib syndrome * Inflammatory pseudotumor (plasma ...
Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder Melani C, Jaffe ES, Wilson WH. ... We have had a longstanding interest in lymphomatoid granulomatosis, an Epstein-Barr virus (EBV) lymphoproliferative disorder ...
Lymphomatoid granulomatosis. Mature T cell and natural killer (NK) cell neoplasms. **T cell prolymphocytic leukemia ...
Lymphomatoid granulomatosis is a rare precancerous condition triggered by Epstein-Barr virus infection. The findings suggest ... NIH study finds that immunotherapy substantially increases survival of people with lymphomatoid granulomatosis Results from a ... clinical trial conducted by CCR researchers show that people with low-grade lymphomatoid granulomatosis who are treated with ...
... lymphomatoid granulomatosis type; and (g) a variant expressing full-length anaplastic large cell lymphoma (2). The prognostic ...
Treatment and Natural History Study of Lymphomatoid Granulomatosis. Participants currently recruited/enrolled. 12-125 Years. ...
Lymphomatoid granulomatosis. Intravascular large B-cell lymphoma. ND. ND. 1,2,3 ...
Lymphomatoid granulomatosis, a single institute experience: pathologic findings and clinical correlations. American Journal of ...
Lymphomatoid granulomatosis with involvement of the hard palate: a case report. J Oral Maxillofac Surg 66(10):2161-3, 2008. ... Lymphomatoid Papulosis With a Unique T Follicular Helper-Like Phenotype (*Mentor of a Medical Student). Am J Dermatopathol. e- ... Lymphomatoid papulosis with DUSP22-IRF4 rearrangement: A case report and literature review. J Cutan Pathol. e-Pub 2023. PMID: ... The differential diagnosis of CD8-positive ("type D") lymphomatoid papulosis *Mentor of a Pathology resident. First place among ...
... granulomatosis with polyangiitis (formerly Wegeners granulomatosis), and lymphomatoid granulomatosis. ...
A diagnosis of isolated central nervous system lymphomatoid granulomatosis (CNS-LYG) was made based on the brain biopsy ... Complete Remission of Acquired Immunodeficiency Syndrome-associated Isolated Central Nervous System Lymphomatoid Granulomatosis ...
... lymphomatoid granulomatosis (LYG), and excessive use of intranasal corticosteroids. WG is commonly associated with PR3-ANCA and ... The aim of our poster is to present several cases of Wegeners granulomatosis (WG) patients with head and neck manifestations ...
Lymphomatoid Granulomatosis. Rabinowitz, J. G., Cohen, B. A. & Mendelson, D. S., 27 Dec 1985, In: JAMA - Journal of the ...
A rare case of pulmonary lymphomatoid granulomatosis that clinically mimics sarcoidosis. p. 951. ...
Pitfall of 18F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis Kelly Tung, Allison C. ... Pitfall of 18F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis Kelly Tung, Allison C. ... Pitfall of 18F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis Kelly Tung, Allison C. ... Pitfall of 18F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis Kelly Tung, Allison C. ...
Lymphomatoid granulomatosis. *Post-transplant lymphoproliferative disorder. *Classic Hodgkin lymphoma. *Burkitts lymphoma. * ...
Lymphomatoid granulomatosis of the central nervous system (CNS-LYG) posing a management challenge. Soleja, M., Jaso, J. M., ...
Lymphomatoid granulomatosis of the central nervous system (CNS-LYG) posing a management challenge. Soleja, M., Jaso, J. M., ...
Lymphomatoid granulomatosis. *Posttransplant lymphoproliferative disorders (PTLDs). *X-linked lymphoproliferative disease ( ...
Lymphomatoid granulomatosis. 1. Vasculitis. 7 (10.4%). CSF analysis. 62 (92%). Pleocytosis. 19 (30.6%). ...
  • Lymphomatoid means lymphoma-like and granulomatosis denotes the microscopic characteristic of the presence of granulomas with polymorphic lymphoid infiltrates and focal necrosis within it. (wikipedia.org)
  • however, there is overwhelming evidence that lymphomatoid granulomatosis is a distinctive type of malignant lymphoma associated with immunosuppression. (medscape.com)
  • Lymphomatoid granulomatosis is considered a distinct form of T cell-rich large B-cell lymphoma. (medscape.com)
  • Lymphomatoid granulomatosis (LYG) is a rare type of angiocentric and angiodestructive lymphoproliferative disorder, which is a type of non-Hodgkin lymphoma. (healthplantip.com)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • The single father of two little boys has a rare lymphoma -- lymphomatoid granulomatosis (LYG). (thebatavian.com)
  • The differential diagnosis of septal perforations associated with WG includes sarcoidosis, cocaine use, SLE, extranodal nasal lymphoma, lymphomatoid granulomatosis (LYG), and excessive use of intranasal corticosteroids. (egms.de)
  • [ 15 ] Simultaneous presentation of multiple myeloma and lymphomatoid granulomatosis in rheumatoid arthritis patients is also reported. (medscape.com)
  • Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized in 1972. (wikipedia.org)
  • Lymphomatoid granulomatosis was first described as a distinct clinicopathologic entity in 1972. (medscape.com)
  • He developed effective therapies for formerly fatal inflammatory and immune-mediated diseases such as polyarteritis nodosa, granulomatosis with polyangiitis (formerly Wegener's granulomatosis), and lymphomatoid granulomatosis. (nih.gov)
  • The aim of our poster is to present several cases of Wegener's granulomatosis (WG) patients with head and neck manifestations including epistaxis, nasal crusting, prolonged sinus infections with atypical microbiological causes and nasal polyposis. (egms.de)
  • Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus -associated systemic angiodestructive lymphoproliferative disease histopathologically defined by angiocentric, angioinvasive and extranodal lesions with polymorphic lymphocyte infiltration. (medscape.com)
  • Lymphomatoid granulomatosis (LYG) involves a B-cell lymphoproliferative process associated with Epstein-Barr virus ( 1 ). (cdc.gov)
  • We describe a 12-year-old boy with Wiskott-Aldrich syndrome who developed a pulmonary vasculitis associated with lymphoreticular proliferation, consistent with the histological and clinical diagnosis of lymphomatoid granulomatosis. (elsevierpure.com)
  • Results from a clinical trial conducted by CCR researchers show that people with low-grade lymphomatoid granulomatosis who are treated with interferon-alpha, a type of immunotherapy, can live for decades after diagnosis. (cancer.gov)
  • An NCI study shows that people with low-grade lymphomatoid granulomatosis who are treated with interferon alfa-2b, a type of immunotherapy, can live for decades after diagnosis. (blueridgecancercare.com)
  • Lymphomatoid granulomatosis (LYG) is an angiocentric destructive proliferation of lymphoid cells predominantly involving the lungs, skin, kidneys, and central nervous system. (survivornet.com)
  • We studied the histological and clinicopathological findings in 42 patients who had lymphomatoid granulomatosis (LYG). (usuhs.edu)
  • Lymphomatoid granulomatosis is a rare disease of unknown prevalence. (medscape.com)
  • Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder. (medscape.com)
  • Lymphomatoid granulomatosis is a rare precancerous condition triggered by Epstein-Barr virus infection. (cancer.gov)
  • Hospitalized with lymphomatoid granulomatosis, a rare cancer, the father of little two boys has only limited means to deal with his illness. (thebatavian.com)
  • [ 2 , 7 ] A small number of patients with isolated lymphomatoid granulomatosis of the CNS (CNS-LYG) have been reported. (medscape.com)
  • This study will evaluate the response and long-term effects of alpha-interferon in patients with lymphomatoid granulomatosis (LYG). (survivornet.com)
  • To determine the response and long-term efficacy of alpha-Interferon in patients with lymphomatoid granulomatosis (LYG). (survivornet.com)
  • The presence of Epstein-Barr virus (EBV) in the large B cells in lymphomatoid granulomatosis has been confirmed in numerous studies, and large B cells showing the presence of EBV-positive cells by in situ hybridization with the EBER probe is now definitional for lymphomatoid granulomatosis according to the WHO. (medscape.com)
  • This graph shows the total number of publications written about "Lymphomatoid Granulomatosis" by people in this website by year, and whether "Lymphomatoid Granulomatosis" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Lymphomatoid Granulomatosis" by people in Profiles. (rush.edu)
  • Lymphomatoid granulomatosis usually is progressive and fatal. (medscape.com)
  • Barakat A, Grover K, Peshin R. Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis. (medscape.com)
  • Pulmonary lymphomatoid granulomatosis in a 4-year-old girl: A case report. (nih.gov)
  • 5. Pulmonary lymphomatoid granulomatosis. (nih.gov)
  • 13. Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. (nih.gov)
  • 19. Expression of cytolytic lymphocyte-associated antigens in pulmonary lymphomatoid granulomatosis. (nih.gov)
  • Gangar P, Venkatarajan S. Granulomatous Lymphoproliferative Disorders: Granulomatous Slack Skin and Lymphomatoid Granulomatosis. (medscape.com)
  • Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized in 1972. (wikipedia.org)
  • Treatment with interferon alfa-2b led to the disappearance of a large lesion (top image) in the lungs of a patient with lymphomatoid granulomatosis, as shown in this computed tomography chest scan. (nih.gov)
  • Results from a clinical trial conducted by researchers at the National Institutes of Health (NIH) show that people with low-grade lymphomatoid granulomatosis who are treated with interferon alfa-2b, a type of immunotherapy, can live for decades after diagnosis . (nih.gov)
  • He and his colleagues treated four people with low-grade lymphomatoid granulomatosis with interferon alfa-2b over a 5-year period, and the treatment eradicated all signs of the disease in three of those patients, known as a complete remission. (nih.gov)
  • That study laid the foundation for the phase 2 trial of interferon alfa-2b in lymphomatoid granulomatosis, which has taken 30 years to complete because of the rarity of the disease and the challenges of recruiting enough patients for the study. (nih.gov)
  • An NCI study shows that people with low-grade lymphomatoid granulomatosis who are treated with interferon alfa-2b, a type of immunotherapy, can live for decades after diagnosis. (feedburner.com)
  • Lymphomatoid Granulomatosis Involving the Lung and Brain in a Child: A Case Report. (nih.gov)
  • A) Bilateral multiple lung nodules and lymphomatoid granulomatosis were diagnosed after lung biopsy. (cdc.gov)
  • 2. Lymphomatoid granulomatosis of the skin and lung. (nih.gov)
  • 17. [Primary and isolated cutaneous lymphomatoid granulomatosis following heart-lung transplantation]. (nih.gov)
  • 1. Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. (nih.gov)
  • 6. EBV-Negative Cutaneous Lymphomatoid Granulomatosis With Concomitant EBV-Positive Pulmonary Involvement: A Potential Diagnostic and Prognostic Pitfall. (nih.gov)
  • 15. Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature. (nih.gov)
  • Primary cutaneous Compact disc30-positive T-cell lymphoproliferative disorders (LPDs), which take into account 30% of cutaneous T-cell lymphomas (CTCLs), express CD30 always, aside from a uncommon subtype called type B lymphomatoid papulosis (LyP) [42]. (spierarchitecturalarts.com)
  • lymphomatoid granulomatosis (LYG)/angiocentric immunoproliferative lesions (AIL) consist of angiocentric and angiodestructive lymphoreticular proliferation predominantly involving the lungs and other extranodal sites, such as the central nervous system (CNS). (lookfordiagnosis.com)
  • Lymphomatoid granulomatosis: a clinical case]. (nih.gov)
  • 4. Lymphomatoid granulomatosis--a single institute experience: pathologic findings and clinical correlations. (nih.gov)
  • A case of lymphomatoid granulomatosis /angiocentric immunoproliferative lesion with long clinical course and diffuse brain involvement. (lookfordiagnosis.com)
  • Although some of these case reports appear promising, larger studies are needed to substantiate the efficacy of rituximab in the treatment of lymphomatoid granulomatosis. (medscape.com)
  • Failure of rituximab monotherapy in lymphomatoid granulomatosis. (medscape.com)
  • Lymphomatoid granulomatosis treated successfully with rituximab in a renal transplant patient. (medscape.com)
  • Cervera P, Guihot A, Gorochov G, Lassoued K, Coppo P. Epstein-Barr virus-driven B Cell Proliferation with CD4(+) T Cell Expansion: A Lymphomatoid Granulomatosis-like Disease Related to Hyperinterleukin-10 Secretion of Remarkably Favourable Outcome with Rituximab. (medscape.com)
  • Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy. (medscape.com)
  • Methotrexate-related lymphomatoid granulomatosis in a patient with rheumatoid arthritis]. (nih.gov)
  • Lymphomatoid granulomatosis is a progressive blood vessel disease characterized by a proliferation of abnormal white blood cells (lymphocytes containing the Epstein-Barr virus) that systematically destroy the small arteries in the lungs, skin, and nervous system by forming harmful nodules in the tissues. (callfred.com)
  • Although lymphomatoid granulomatosis is uncommon, the effects of high-grade disease can be debilitating," said Jeffrey Cohen, M.D., chief of the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Diseases and a co-leader of the study. (nih.gov)
  • A patient with lymphomatoid granulomatosis and positive EBV serology post-stem cell transplant for multiple myeloma was reported to have complete radiologic remission following 2 weeks of ganciclovir therapy. (medscape.com)
  • Lymphomatoid granulomatosis (LYG) involves a B-cell lymphoproliferative process associated with Epstein-Barr virus ( 1 ). (cdc.gov)
  • Primary orbital lymphomatoid granulomatosis. (medscape.com)
  • Primary cerebral lymphomatoid granulomatosis: report of four cases and literature review. (medscape.com)
  • Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b. (medscape.com)
  • Lymphomatoid granulomatosis of the vulva: case report with immunohistochemical analysis. (medscape.com)
  • 8. Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis. (nih.gov)
  • Lymphomatoid granulomatosis is more common in males than in females and usually presents between ages 30 - 50. (callfred.com)
  • The trial included 67 people with lymphomatoid granulomatosis, 37 with low-grade disease and 30 with high-grade disease. (nih.gov)
  • Grade III lymphomatoid granulomatosis is a disabling condition on the Compassionate Allowance List , which qualifies an individual for an expedited approval process. (callfred.com)
  • Grade III lymphomatoid granulomatosis automatically qualifies you for social security disability benefits under the Social Security Administration's guidelines. (callfred.com)
  • If you or a loved one has been diagnosed with grade III lymphomatoid granulomatosis, contact an experienced social security disability lawyer today. (callfred.com)
  • This study will evaluate the response and long-term effects of alpha-interferon in patients with lymphomatoid granulomatosis (LYG). (nih.gov)