A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A general term for various neoplastic diseases of the lymphoid tissue.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.
A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Antibodies obtained from a single clone of cells grown in mice or rats.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tumors or cancer of the MEDIASTINUM.
An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.
A DNA-binding protein that represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES. Aberrant Blc-6 expression is associated with certain types of human B-CELL LYMPHOMA.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Therapeutic act or process that initiates a response to a complete or partial remission level.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Antibodies produced by a single clone of cells.
Transplantation of an individual's own tissue from one site to another site.
A cell line derived from cultured tumor cells.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Ordered rearrangement of B-lymphocyte variable gene regions of the IMMUNOGLOBULIN HEAVY CHAINS, thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the IMMATURE B-LYMPHOCYTES.
The return of a sign, symptom, or disease after a remission.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Tumors or cancer of the THYMUS GLAND.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.
DNA present in neoplastic tissue.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Tumors or cancer of the EYE.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Tumors or cancer of the NOSE.
A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumors or cancer of the SKIN.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Elements of limited time intervals, contributing to particular results or situations.
An octamer transcription factor expressed primarily in B-LYMPHOCYTES and the developing CENTRAL NERVOUS SYSTEM that regulates GENETIC TRANSCRIPTION of IMMUNOGLOBULIN GENES.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. It is expressed almost exclusively in B-LYMPHOCYTES and serves as a useful marker for B-cell NEOPLASMS.
Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.
Family of retrovirus-associated DNA sequences (v-rel) originally isolated from an avian reticuloendotheliosis virus strain. The proto-oncogene rel (c-rel) codes for a subcellular (nuclear and cytoplasmic) transcription factor that has a role in lymphocyte differentiation. Translocation or overexpression of c-rel or competition from v-rel causes oncogenesis. The human rel gene is located at 2p12-13 on the short arm of chromosome 2.
A transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.
A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
An experimental lymphocytic leukemia of mice.
A primary peripheral T-cell lymphoma in the gastrointestinal tract, most often in the jejunum, associated with a history of CELIAC DISEASE or other gastrointestinal diseases.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Two or more distinct types of malignant lymphoid tumors occurring within a single organ or tissue at the same time. It may contain different types of non-Hodgkin lymphoma cells or both Hodgkin and non-Hodgkin lymphoma cells.
Tumors or cancer of the INTESTINES.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the kappa or lambda IMMUNOGLOBULIN LIGHT CHAINS, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the IMMATURE B-LYMPHOCYTES.
Established cell cultures that have the potential to propagate indefinitely.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Neoplasms of the bony orbit and contents except the eyeball.
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the STOMACH.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
A galectin found abundantly in smooth muscle (MUSCLE, SMOOTH) and SKELETAL MUSCLE and many other tissues. It occurs as a homodimer with two 14-kDa subunits.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A lectin and cell adhesion molecule found in B-LYMPHOCYTES. It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A statistically significant excess of cases of a disease, occurring within a limited space-time continuum.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
A method of providing future reproductive opportunities before a medical treatment with known risk of loss of fertility. Typically reproductive organs or tissues (e.g., sperm, egg, embryos and ovarian or testicular tissues) are cryopreserved for future use before the medical treatment (e.g., chemotherapy, radiation) begins.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
A superorder of CEPHALOPODS comprised of squid, cuttlefish, and their relatives. Their distinguishing feature is the modification of their fourth pair of arms into tentacles, resulting in 10 limbs.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

The role of alternative splicing of the adhesion molecule, CD44, in lymphoid malignancy. (1/3916)

AIM: To investigate the expression of CD44 isoforms containing variant exon 6 (v6) in a well characterised cohort of patients with non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), and to correlate this with phenotype and disease course. METHODS: Cryostat sections of OCT embedded diagnostic nodal material from NHL patients and cryopreserved mononuclear preparations from CLL patients were used as sources of RNA. After reverse transcription, PCR was carried out with amplimers positioned at either side of the variant exon insertion site to amplify all possible CD44 isoforms. Those isoforms containing v6 were identified after Southern blotting and hybridisation with a radiolabelled oligonucleotide. RESULTS: Of 32 NHL samples analysed, 16 did not express CD44 isoforms containing v6, six expressed an isoform containing exon v6 alone, and 10 expressed v6 long isoforms which contained exon v6 in addition to other variant exons. These data did not correlate with lymphoma classification, disease staging, or the presence or absence of extranodal disease. However, those patients expressing v6 long CD44 isoforms had a worse overall survival than those that did not. The plateau of the survival curves was 50% compared with 82%. No v6 long isoforms were detected in the 21 CLL samples investigated. CONCLUSIONS: The expression of v6 long CD44 isoforms is associated with aggressive disease in NHL, independent of grade, stage, or presence of extranodal disease.  (+info)

Incidence and occupational pattern of leukaemias, lymphomas, and testicular tumours in western Ireland over an 11 year period. (2/3916)

STUDY OBJECTIVE: To determine incidence of the following malignancies, testicular tumours, all leukaemias and all lymphomas in the West of Ireland in an 11 year period. Secondly, to examine the relation between disease patterns and available occupational data in male subjects of working age. DESIGN: A census survey of all cases occurring in the three counties in the Western Health Board (WHB) area, Galway, Mayo and Roscommon, for the 11 year period 1980 to 1990 inclusive. Average annual age standardised incidence rates for the period were calculated using the 1986 census data. Rates for the area are compared with rates from the southern region of Ireland, which had a tumour registry. Trends over the time period are evaluated. All male subjects for whom occupational data were available were categorised using the Irish socioeconomic group classification and incidence rates by occupation were compared using the standardised incidence ratio method. In one of the counties, Galway, a detailed occupational history of selected cases and an age matched control group was also elicited through patients' general practitioners. SETTING: All available case records in the West of Ireland. RESULTS: There are no national incidence records for the period. Compared with data from the Southern Tumour Registry, the number of cases of women with myeloid leukaemias was significantly lower. Male leukaemia rates were significantly lower as a group (SIR 84 (95% CI 74, 95) but not when considered as individual categories. Regression analysis revealed an increasing trend in the number of new cases of non-Hodgkin's lymphoma among both men (r = 0.47, p = 0.02) and women (r = 0.90, p = 0.0001) and of chronic lymphocytic leukaemia in men (r = 0.77, p = 0.005) and women (r = 0.68 p = 0.02) in the WHB region over the last decade. Four hundred and fifty six male cases over the age of 15 years were identified and adequate occupational information was available for 74% of these. Standardised incidence ratios of testicular tumours 100, 938) and agriworkers other than farmers (SIR 377, 95% CI 103, 967). There were also significantly increased incidence ratios for both non-Hodgkin's lymphoma (SIR 169, 95% CI 124, 266) and three categories of leukaemias among farmers. Hodgkin's disease and acute myeloid leukaemias were significantly increased among semi-skilled people. Interview data with 90 cases and 54 controls of both sexes revealed that among farmers, cases (n = 31) were significantly less likely than controls (n = 20) to use tractor mounted spraying techniques (OR = 0.19 (95% CI 0.04, 0.80)) and less likely to wear protective masks (OR 0.22 (95% CI 0.05, 0.84)). CONCLUSIONS: Trends of increase in non-Hodgkin's lymphoma and some leukaemias are consistent with studies elsewhere. The study provides further evidence of the relation between agricultural work and certain lymphoproliferative cancers. The possible carcinogenic role of chemicals used in agricultural industries must be considered as an explanation.  (+info)

67Cu-2IT-BAT-Lym-1 pharmacokinetics, radiation dosimetry, toxicity and tumor regression in patients with lymphoma. (3/3916)

Lym-1, a monoclonal antibody that preferentially targets malignant lymphocytes, has induced therapeutic responses and prolonged survival in patients with non-Hodgkin's lymphoma when labeled with 1311. Radiometal-labeled antibodies provide higher tumor radiation doses than corresponding 1311 antibodies. 67Cu has an exceptional combination of properties desirable for radioimmunotherapy, including gamma and beta emissions for imaging and therapy, respectively, a biocompatible half-time and absence of pathways contributing to myelotoxicity. The radioimmunoconjugate, 67Cu-21T-BAT-Lym-1, has been shown to be efficacious in nude mice bearing human Burkitt's lymphoma (Raji) xenografts. Based on these results, a clinical study of the pharmacokinetics and dosimetry of 67Cu-21T-BAT-Lym-1 in patients with lymphoma was initiated. METHODS: Eleven patients with advanced stage 3 or 4 lymphoma were given a preload dose of unmodified Lym-1, then an imaging dose of 126-533 MBq (3.4-14.4 mCi) 67Cu-21T-BAT-Lym-1. Total Lym-1 ranged from 25 to 70 mg dependent on the specific activity of the radioimmunoconjugate and was infused at a rate of 0.5-1 mg/min. Imaging, physical examination, including caliper measurement of superficial tumors, and analysis of blood, urine and fecal samples were performed for a period of 6-13 d after infusion to assess pharmacokinetics, radiation dosimetry, toxicity and tumor regression. RESULTS: In 7 patients, in whom superficial tumors had been accurately measured, tumors regressed from 18% to 75% (mean 48%) within several days of 67Cu-21T-BAT-Lym-1 infusion. The uptake and biological half-time of 67Cu-21T-BAT-Lym-1 in tumors were greater than those of normal tissues, except the mean liver half-time exceeded the mean tumor half-time. The mean tumor-to-marrow radiation ratio was 32:1, tumor-to-total body was 24:1 and tumor-to-liver was 1.5:1. Images were of very good quality; tumors and normal organs were readily identified. Mild and transient Lym-1 toxicity occurred in 6 patients; 1 patient developed a human antimouse antibody. There were no significant changes in blood counts or serum chemistries indicative of radiation toxicity. CONCLUSION: Because of the long residence time of 67Cu-21T-BAT-Lym-1 in tumors, high therapeutic ratios were achieved and, remarkably, numerous tumor regressions were observed after imaging doses. The results indicate considerable therapeutic potential for 67Cu-21T-BAT-Lym-1.  (+info)

Second-line treatment for primary central nervous system lymphoma. (4/3916)

Failure after first-line treatment was reported in 35-60% of immunocompetent patients with primary central nervous system lymphoma (PCNSL). There are currently no reports focusing on salvage therapy. This review analyses prognostic factors and the efficacy of salvage therapy by focusing on data from papers reporting results of first-line treatment in 355 cases. The study group consisted of 173 patients presenting treatment failure. The interval between failure and death (TTD) was compared for age at relapse (< or =60 vs. >60 years), type of failure (relapse vs. progression), time to relapse (< or =12 vs. >12 months) and salvage treatment (yes vs no). Median TTD was similar in younger and older patients (P = 0.09). Relapsed patients had a longer TTD than patients with progressive disease (P = 0.002). Early relapse led to a shorter TTD than late relapse (P = 0.005). Median TTD was 14 months for patients who underwent salvage therapy and 2 months for untreated cases (P<0.00001). A multivariate analysis showed an independent prognostic role for salvage therapy and time to relapse. Age and type of failure had no predictive value. Salvage therapy significantly improves outcome and, possibly, quality of life. As many different treatments were used conclusions cannot be made regarding an optimal treatment schedule.  (+info)

Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin's disease and lymphocyte-rich classical Hodgkin's disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin's Disease. (5/3916)

PURPOSE: Recent studies have suggested that lymphocyte-predominant Hodgkin's disease (LPHD) is both clinically and pathologically distinct from other forms of Hodgkin's disease, including classical Hodgkin's disease (CHD). However, large-scale clinical studies were lacking. This multicenter, retrospective study investigated the clinical characteristics and course of LPHD patients and lymphocyte-rich classical Hodgkin's disease (LRCHD) patients classified according to morphologic and immunophenotypic criteria. MATERIALS AND METHODS: Clinical data and biopsy material of all available cases initially submitted as LPHD were collected from 17 European and American centers, stained, and reclassified by expert pathologists. RESULTS: The 426 assessable cases were reclassified as LPHD (51%), LRCHD (27%), CHD (5%), non-Hodgkin's lymphoma (3%), and reactive lesion (3%); 11% of cases were not assessable. Patients with LPHD and LRCHD were predominantly male, with early-stage disease and few risk factors. Patients with LRCHD were significantly older. Survival and failure-free survival rates with adequate therapy were similar for patients with LPHD and LRCHD, and were stage-dependent and not significantly better than stage-comparable results for CHD (German trial data). Twenty-seven percent of relapsing LPHD patients had multiple relapses, which is significantly more than the 5% of relapsing LRCHD patients who had multiple relapses. Lymphocyte-predominant Hodgkin's disease patients had significantly superior survival after relapse compared with LRCHD or CHD patients; however, this was partly due to the younger average age of LPHD patients. CONCLUSION: The two subgroups of LPHD and LRCHD bore a close clinical resemblance that was distinct from CHD; the course was similar to that of comparable nodular sclerosis and mixed cellularity patients. Thorough staging is necessary to detect advanced disease in LPHD and LRCHD patients. The question of how to treat such patients, either by reducing treatment intensity or following a "watch and wait" approach, remains unanswered.  (+info)

ESHAP as salvage therapy for refractory non-Hodgkin's lymphoma: Taiwan experience. (6/3916)

BACKGROUND: The ESHAP regimen, a combination of the chemotherapeutic drugs etoposide, methylprednisolone (solumedrol), high-dose cytarabine (ara-C) and cisplatin, has been shown to be active against refractory non-Hodgkin's lymphoma in therapeutic trials. We were interested in determining whether this regimen would be effective and tolerable for Chinese patients. METHODS: Thirty-two patients with refractory/relapsed non-Hodgkins lymphoma (23 intermediate-grade and nine high-grade) were enrolled in this study. Etoposide was administered at a dose of 40 mg/m2/day as a 1 h intravenous infusion from day 1 to day 4, solumedrol 500 mg/day was given as a 15 min intravenous infusion from day 1 to day 5, ara-C 2 g/m2 was given as a 2 h intravenous infusion on day 5 and cisplatin was given at a dose of 25 mg/m2/day as a continuous infusion from day 1 to day 4. Clinical efficacy and toxicity were assessed on the basis of the WHO criteria. RESULTS: Ten patients (31.3%, 95% Cl 15.2-47.4%) attained complete remission (CR) and seven had partial remission (PR). The overall response rate was 53.1% (95% Cl 35.8-70.4%). In eight of the 10 CR patients, the remission lasted for more than 8 months. The remaining two patients had CR of 5 and 6 months. The median duration of CR was 12.2 months (range 5-22 months). Myelosuppression with subsequent infections was the major toxicity. Severe leukopenia (WBC < 1000/microliter) lasted for an average of 12 days and thrombocytopenia (< 25,000/microliter) 18 days. One patient (3.1%) died of neutropenia-associated sepsis within 4 weeks after treatment. Non-myeloid toxicities included alopecia in 66% (28% grade 2, 22% grade 3), stomatitis in 72% (25% grade 2, 28% grade 3, 13% grade 4), hepatotoxicity in 9% (3% grade 2), renal toxicity in 13% (6% grade 2, 3% grade 3) and infection in 56% (18% grade 2, 25% grade 3, 13% grade 4). The majority of the responders relapsed within 2 years after ESHAP treatment. Median survival for all patients was 8.6 months. CONCLUSIONS: ESHAP is an active and tolerable regimen in Chinese patients with relapsed/refractory lymphoma, but the duration of remission is brief and without significant impact on survival.  (+info)

Fludarabine, cyclophosphamide, and dexamethasone (FluCyD) combination is effective in pretreated low-grade non-Hodgkin's lymphoma. (7/3916)

PURPOSE: Fludarabine phosphate is effective as a single agent in low-grade non-Hodgkin's lymphoma (NHL). Combined with other antineoplastic agents it enhances the antitumor effect. Our aim was to define the therapeutic efficacy and toxicity of a combination of fludarabine, cyclophosphamide and dexamethasone (FluCyD) in patients with advanced low-grade lymphoma. PATIENTS AND METHODS: Twenty-five adults with pretreated advanced-stage low-grade NHL were treated with three-day courses of fludarabine 25 mg/m2/day, cyclophosphamide 350 mg/m2/day, and dexamethasone 20 mg/day, every four weeks for a maximum of six courses. RESULTS: Of the 25 patients, 18 (72%) responded, 8 (32%) achieving CR and 10 (40%) PR. Seven were failures. The median follow-up was 21 months (5-26). Eight CR patients remain in CR after 5-21 months. Of 10 PR patients, 3 are in continuous PR without further treatment after 12, 17 and 18 months. Myelosuppression was the most prevalent toxic effect. Although severe granulocytopenia (granulocyte count nadir < 500/microliter) and thrombocytopenia (platelet count nadir < 50,000/microliter) occurred in only 10% and 16% of courses, respectively, slow granulocyte or platelet count recovery caused delay of 40% of the courses. Nine patients (36%) required discontinuation of therapy because of persistent granulocytopenia and/or thrombocytopenia: three after one course, three after 2-4 courses, and three after five courses. Thirteen infectious episodes in 11 patients complicated 11% of courses. Two of 10 patients monitored for the circulating EBV load showed increased viral load. One of these developed aggressive lymphoma. CD4+ lymphocytes declined from a pre-therapy median value of 425/microliter to 141/microliter post-treatment (P = 0.001). Non-hematologic toxicities were rare and mild. CONCLUSIONS: The combination of fludarabine with cyclophosphamide and dexamethasone is effective in pretreated advanced-stage low-grade NHL. It may broaden the range of therapeutic options in the salvage treatment of these patients. The main toxicity of this combination is prolonged myelosuppression that may cause treatment delay or withdrawal. The benefit of adding granulocyte colony-stimulating factor, particularly in patients with poor marrow reserve, needs to be investigated.  (+info)

Is primary CNS lymphoma really becoming more common? A population-based study of incidence, clinicopathological features and outcomes in Alberta from 1975 to 1996. (8/3916)

BACKGROUND: The incidence of primary CNS lymphoma (PCNSL) is believed to be increasing in immunocompetent patients but this may not be universally true. The objective of this study was to determine in a population if the incidence of PCNSL is increasing, if the histologic subtypes are changing, and to describe the clinicopathologic and outcome characteristics of PCNSL. PATIENTS AND METHODS: We identified all Alberta residents with a histologic diagnosis of PCNSL from 1 January 1975 to 31 December 1996 using the Alberta Cancer Registry. Annual age-standardized incidence rates (ASIR), clinicopathologic and outcome characteristics were determined. RESULTS: There were 50 immunocompetent PCNSL patients; the median age was 64 and 30 were male. Their median survival was 10.15 months. Histology was available for review in 37 (74%) patients: 19 (51%) were diffuse large cell, 16 (43%) were immunoblastic and 2 (5%) were unclassifiable malignant lymphomas. The ASIR ranged from 0.178-1.631/10(6) and no change in ASIR was found (test for trend, P = 0.26) for gender or age. The ASIR of malignant gliomas did not change either but increased for all other non-Hodgkin's lymphoma (94.95-138.7610(6); test for trend, P = 0.0001) The number of brain biopsies increased from 1979-1985 (test for trend, P < 0.0001) but remained stable from 1986-1996 (test for trend, P = 0.99). CONCLUSIONS: Unlike several other populations, PCNSL is not becoming significantly more common in Alberta. If this difference is real (i.e., not due to differences in cancer registry coding practices etc.) comparisons between Albertans and other populations in whom the incidence is rising may provide clues regarding the etiology of PCNSL.  (+info)

This is a Phase II single arm study of a novel T cell immunotherapy in patients with indolent non-Hodgkins lymphoma (NHL). Eligible patients will have
Patients with previously untreated low tumor burden indolent Non-Hodgkins Lymphoma (NHL) will receive either rituximab or GA101 weekly for 4 weeks foll
Gilead Sciences announced interim results from its Phase 2 Study 101-09 evaluating idelalisib, an oral PI3K delta inhibitor for the treatment of patients with indolent non-Hodgkins lymphoma that is refractory to rituximab and to alkylating-agent containing chemotherapy. If approved it may provide a new treatment option to patients with few remaining conventional treatment options.
TY - JOUR. T1 - Metabolic Characterization of Human Non-Hodgkins Lymphomas in Vivo with the Use of Proton-decoupled Phosphorus Magnetic Resonance Spectroscopy. AU - Negendank, William G.. AU - Padavic-Shaller, Kristin A.. AU - Li, Chun Wei. AU - Murphy-Boesch, Joseph. AU - Stoyanova, Radka. AU - Krigel, Robert L.. AU - Schilder, Russell J.. AU - Smith, Mitchell R.. AU - Brown, Truman R.. PY - 1995/8/1. Y1 - 1995/8/1. N2 - Development of biological and clinical uses of in vivo 31P magnetic resonance spectroscopy has been hampered by poor anatomic localization of spectra and poor resolution of overlapping signals within phosphomonoester and phosphodiester regions of the spectrum. We applied 1H decoupling and nuclear Overhauser enhancement to improve resolution of 31P magnetic resonance spectra accurately localized to 21 non-Hodgkins lymphomas (NHL) by using three-dimensional chemical shift imaging. All 21 spectra had large phosphomonoester signals (26% of total phosphorus) that contained high ...
Key clinical point: A bispecific anti-CD19, anti-CD20 chimeric antigen receptor (CAR) T cell approach is safe and produced complete responses in the majority of patients with relapsed or refractory non-Hodgkin lymphoma.Major finding: Eleven of 17 assessable patients had a response to treatment, and of those 11 patients, 9 had complete responses, all of which are ongoing.Study details: A phase 1 study of 17 patients with relapsed or refractory B-cell non-Hodgkin lymphomas.
Biopsy-proven relapsed or refractory non-Hodgkin lymphoma requiring treatment, who have failed, unable to tolerate, or refused other available active therapies; patients should not have other treatment options considered curative (NOTE: for patients with lymphoma without CNS involvement, a re-biopsy is necessary unless the patient has had a previous biopsy ≤ 6 months prior to treatment on this protocol if there has been no intervening treatment; patients with biopsy-proven CNS lymphoma at any time are not required to have a rebiopsy to be eligible for this study); NOTE: relapsed NHL is defined as NHL that relapses after at least one prior therapy and does not have available curative therapy; refractory NHL is defined as NHL that has progressed or not responded to most recent therapy and has had at least one prior therapy and have no available curative ...
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: Phase I trial to determine the effectiveness of thal
The UNM Comprehensive Cancer Center is the Official Cancer Center of New Mexico and the only National Cancer Institute-designated Comprehensive Cancer Center in the state.
This study aimed to systematically review and meta-analyze the value of pretransplant FDG-PET in predicting outcome after autologous stem cell transplantation (ASCT) in aggressive non-Hodgkin lymphoma. Medline was systematically searched, included studies were methodologically assessed and meta-analyzed, when possible. Overall methodological quality of included studies (n=11) was poor, with moderate ... read more risk of bias in the domains of study participation (n=7) and prognostic factor measurement (n=7), and high risk of bias in the domains of outcome measurement (n=10), and study confounding (n=11). In all aggressive non-Hodgkin lymphomas, pooled sensitivity and specificity were 54.0% and 73.1% in predicting treatment failure, and 54.5% and 68.7% in predicting death. Because of interstudy heterogeneity, additional subgroup analyses were performed. In newly diagnosed aggressive non-Hodgkin lymphoma, pooled sensitivity and specificity were 20.0% and 70.0% in predicting treatment failure, and ...
A recent study conducted by researchers from the Yale School of Public Health in New Haven, Connecticut has revealed that women who are exposed to organic solvents while at work have a higher risk of getting non-Hodgkin lymphoma. About Non-Hodgkin Lymphoma According to the Mayo Clinic, non-Hodgkin lymphoma originates from ones lymphatic system, the core disease-repelling system in the human body. In this condition, tumors arise from lymphocytes, which are a kind of white blood cell. In its initial stages, symptoms of the ailment may only be the presence of swollen lymph nodes in ones neck, armpit or groin areas; these are usually painless. Other possible warning signs include fever, fatigue, weight loss, abdominal swelling or pain, difficulty breathing, and very itchy skin. Statistics from the National Cancer Institute reveal that there were 66,120 new cases of non-Hodgkin lymphoma in the US in 2008, with 19,160 persons dying from it. According to the researchers, its incidence has increased ...
TY - JOUR. T1 - Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkins lymphoma. AU - Wiernik, Peter H.. AU - Lossos, Izidore S.. AU - Tuscano, Joseph M.. AU - Justice, Glen. AU - Vose, Julie Marie. AU - Cole, Craig E.. AU - Lam, Wendy. AU - McBride, Kyle. AU - Wride, Kenton. AU - Pietronigro, Dennis. AU - Takeshita, Kenichi. AU - Ervin-Haynes, Annette. AU - Zeldis, Jerome B.. AU - Habermann, Thomas M.. PY - 2008/10/20. Y1 - 2008/10/20. N2 - Purpose: The major cause of death in aggressive lymphoma is relapse or nonresponse to initial therapy. Lenalidomide has activity in a variety of hematologic malignancies, including non-Hodgkins lymphoma (NHL). We report the results of a phase II, single-arm, multicenter trial evaluating the safety and efficacy of lenalidomide oral monotherapy in patients with relapsed or refractory aggressive NHL. Patients and Methods: Patients were treated with oral lenalidomide 25 mg once daily on days 1 to 21, every 28 days, for 52 weeks, until ...
Lymphomas account for 5% of all cancers in the United States, with Non-Hodgkins lymphoma being far more prevalent than Hodgkins lymphoma. It is estimated that in 2012, 70,130 will be diagnosed with Non-Hodgkins lymphoma and 9,060 will be diagnosed with Hodgkins lymphoma. Further, it is estimated that 18,940 people will die from Non-Hodgkins lymphoma and 1,190 people will die from Hodgkins lymphoma this year. One out of every 47 people will be diagnosed with Non-Hodgkins lymphoma and one out of every 436 people will be diagnosed with Hodgkins lymphoma in their lifetimes. In the US, we spend approximately $10.2 billion annually treating lymphoma.. NCI allocated 2.7% of its annual budget (or $137.0 million) in 2010 for lymphoma research.. The information in this section was also provided to the public courtesy of the NCI. You can find more information about lymphoma in their What You Need to Know About Hodgkins Lymphoma and What You Need to Know About Non-Hodgkins Lymphoma booklets, here and ...
Non-Hodgkins lymphoma (or NHL) is one of the most common cancers among 9/11 responders and survivors. Turley Hansen has represented many claimants with Non-Hodgkin lymphoma since cancer was added to the list of illnesses covered under the Zadroga Act.. Non-Hodgkins lymphoma, also called non-Hodgkins lymphoma or NHL, is a cancer that originates in your lymph system - the network spread throughout your body to fight diseases. In non-Hodgkins lymphoma, tumors develop from lymphocytes - a type of white blood cell.. Non-Hodgkins lymphoma is more common than the other general type of lymphoma - Hodgkins lymphoma. Many different sub-types of non-Hodgkins lymphoma exist. The most common non-Hodgkins lymphoma sub-types include diffuse large B-cell lymphoma and follicular lymphoma.. ...
DISEASE CHARACTERISTICS: Histologically confirmed intermediate or high grade non-Hodgkins lymphoma, acute myelogenous leukemia, or acute lymphocytic leukemia that is refractory to or relapsed after prior therapy Must be HIV seropositive confirmed by Western blot Must have a 6/6 HLA matched sibling donor or 6/6, 5/6, or 4/6 HLA matched umbilical cord blood (UCB) from the New York Blood Centers Unrelated UCB Bank that is not homozygous for the CCR-5 mutation No active primary CNS lymphoma or chronic CNS infection No history of AIDS defining opportunistic infection or active invasive aspergillus infection A new classification scheme for adult non-Hodgkins lymphoma has been adopted by PDQ. The terminology of indolent or aggressive lymphoma will replace the former terminology of low, intermediate, or high grade lymphoma. However, this protocol uses the former terminology.. PATIENT CHARACTERISTICS: Age: 18 to 55 Performance status: Karnofsky 70-100% Life expectancy: At least 6 months ...
1 Hermans J, Drol AD, van Groningen K, et al. International Prognostic Index for aggressive non-Hodgkin lymphoma is valid for all malignancy grades. Blood. 1995l86:1460-1463.. 2 Alici S, Bavbek SE, Kaytan E, et al. Prognostic significance of the immunophenotype versus the International Prognostic Index in aggressive non-Hodgkin lymphoma. Clinical Lymphoma. 2003;4:52-55.. 3 De Santis V, Martelli M, Anticoli AP, et al. Localized stage I-IE aggressive non-Hodgkin lymphoma (NHL): results of prospective study with multimodality therapeutic approach. Anticancer Research. 2001;21:4169-4172.. 4 Bernard M, Cartron G, Rachieru P, et al. Long-term outcome of localized high-grade non-Hodgkin lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study. Haematologica. 2005:90:802-809.. 5 Roche. Study of MabThera in aggressive non-Hodgkin lymphoma in patients less than 60 years old halted two years early due to ...
Biopsy proven intermediate or high grade non-Hodgkins lymphoma (Working formulation groups D through H and J) except lymphoblastic lymphoma (Working formulation group I); no transformed lymphomas; High-Intermediate or High Risk Groups; Stage III, Stage IV, or bulky Stage II; bidimensionally measureable disease; BM aspirate and biopsy; CT scan of chest, abdomen, and pelvis; no CNS involvement; no non-lymphoma related hepatic and/or renal dysfunction; no prior chemo for lymphoma except for one cycle of CHOP prior to registration (if so all eligibility requirements for first registration must have been completed prior to the start of the first cycle of CHOP); no prior RT for lymphoma; no coronary artery disease, cardiomyopathy, congestive heart failure, or dysrhythmia requiring therapy; no known allergy to etoposide or a history of Grade 3 hemorrhagic cystitis with cyclophosphamide; no known AIDS or HIV ...
Full Title A Phase III, Randomized, Double-Blind, Controlled, Multicenter Study of Intravenous PI3K Inhibitor Copanlisib in Combination with Standard Immunochemotherapy versus Standard Immunochemotherapy in Patients with Relapsed Indolent Non-Hodgkins Lymphoma (iNHL) - CHRONOS-4 Purpose The purpose of this study is to compare treatment with copanlisib plus standard immunochemotherapy with immunochemotherapy alone in patients with slow-growing non-Hodgkin lymphoma (NHL) that has come back despite prior therapy.
Lymphomas account for 5% of all cancers in the United States, with Non-Hodgkins lymphoma being far more prevalent than Hodgkins lymphoma. It is estimated that in 2012, 70,130 will be diagnosed with Non-Hodgkins lymphoma and 9,060 will be diagnosed with Hodgkins lymphoma. Further, it is estimated that 18,940 people will die from Non-Hodgkins lymphoma and 1,190 people will die from Hodgkins lymphoma this year. One out of every 47 people will be diagnosed with Non-Hodgkins lymphoma and one out of every 436 people will be diagnosed with Hodgkins lymphoma in their lifetimes. In the US, we spend approximately $10.2 billion annually treating lymphoma.. NCI allocated 2.7% of its annual budget (or $137.0 million) in 2010 for lymphoma research.. The information in this section was also provided to the public courtesy of the NCI. You can find more information about lymphoma in their What You Need to Know About Hodgkins Lymphoma and What You Need to Know About Non-Hodgkins Lymphoma booklets, here and ...
DUBLIN, June 11, 2019 /PRNewswire/ -- The Global Non-Hodgkin Lymphoma Clinical Trial Pipeline Highlights - 2019 report has been added to ResearchAndMarkets.coms offering. Non-Hodgkin Lymphoma Pipeline Highlights - 2019, provides most up-to-date information on key pipeline products in the global Non-Hodgkin Lymphoma market. It covers emerging therapies for Non-Hodgkin Lymphoma in active clinical development stages including early and late stage clinical trials. The pipeline data presented in this report helps executives for tracking competition, identifying partners, evaluating opportunities, formulating business development strategies, and executing in-licensing and out-licensing deals.. Clinical Trial Stages:. The report provides Non-Hodgkin Lymphoma pipeline products by clinical trial stages including both early and late stage development - phase 3 clinical trials, phase 2 clinical trials, phase 1 clinical trials, preclinical research, and discovery stage.. Drug Mechanism Classes:. The ...
TY - JOUR. T1 - Allogeneic transplantation for recurrent or refractory non-Hodgkins lymphoma with poor prognostic features after conditioning with thiotepa, busulfan, and cyclophosphamide. T2 - Experience in 44 consecutive patients. AU - Van Besien, Koen. AU - Thall, Peter. AU - Korbling, Martin. AU - Pugh, William C.. AU - Khouri, Issa. AU - Mehra, Rakesh. AU - Giralt, Sergio. AU - Anderlini, Paolo. AU - Amin, Kamal. AU - Mirza, Nadeem. AU - Seong, David. AU - Gajewski, James. AU - Hester, Jeane. AU - Andersson, Borje. AU - Cabanillas, Fernando. AU - Champlin, Richard. AU - Przepiorka, Donna. PY - 1997/8/1. Y1 - 1997/8/1. N2 - We report the outcomes of 44 consecutive patients with non-Hodgkins lymphoma (NHL) who participated in prospective studies of allogeneic transplantation after conditioning with thiotepa, busulfan and cyclophosphamide. Within a range of 27-57 years, the median age was 37. Of the 44 patients, 12 (27.2%) had high-grade lymphomas, 27 (61.4%) had intermediate-grade ...
PRIMARY OBJECTIVES:. I. To determine the efficacy of MLN8237 (alisertib) alone in patients with relapsed and refractory non-Hodgkin lymphoma (NHL) and transformed NHL.. SECONDARY OBJECTIVES:. I. To determine the efficacy of MLN8237 when combined with rituximab in NHL patients who fail to respond to MLN8237 alone in patients with relapsed and refractory NHL and transformed NHL.. II. To determine specific toxicities associated with MLN8237 alone and when combined with rituximab (in NHL patients) in patients with relapsed and refractory NHL and transformed NHL.. III. To determine pharmacokinetics of MLN8237 alone and in combination with rituximab (for NHL patients) in patients with relapsed and refractory NHL and transformed NHL.. IV. To evaluate specific molecular characteristics of the NHL for patients treated with MLN8237 alone and with rituximab in order to correlate particular molecular markers with response and survival.. V. To evaluate long term survival of patients treated with MLN8237 ...
Low-grade non-Hodgkins lymphoma (NHL) is an indolent form of the disease with a generally slow course of progression. Although still usually incurable, low-grade disease has shown responsiveness to some of the newer
The beta 2-adrenergic transmembrane signal transduction was investigated in malignant B-cells from 15 patients with low grade non-Hodgkins lymphoma as compared with normal lymphocytes of seven healthy adults. The number of beta 2-adrenoceptors and the response of adenylate cyclase (AC) to isoproterenol were slightly decreased in lymphoma cells. The responsiveness of AC to forskolin was 8-fold lower in lymphoma cells, whereas the response to cholera toxin showed no difference. These findings demonstrate an impairment of the beta 2-adrenergic signal transduction in low grade lymphoma cells that particularly affects the function of AC. The comparison with forskolin resistant mutants of an adrenocortical tumor cell line, Y1 (Schimmer et al., J Biol Chem 262: 15521-15526, 1987), suggests that the availability of functional active alpha subunits of stimulatory G proteins (Gs) might be reduced in human B-cell lymphoma, although other mechanisms known to inhibit the AC activity might be involved. ...
Middelkoop, O P.; Roos, E; and Pavert, I V., Infiltration of lymphosarcoma cells into hepatocyte cultures: inhibition of univalent antibodies against liver plasma membranes and lymphosarcoma cells. (1982). Subject Strain Bibliography 1982. 3428 ...
There are numerous signs and symptoms that can indicate that an individual has developed non-Hodgkins lymphoma. Because the condition can affect numerous areas of the body, the symptoms of the condition can also be found in several areas of the body. Not ever patient diagnosed with non-Hodgkins lymphoma will experience all of the symptoms of the condition and some of the indicating symptoms may appear without the individual developing non-Hodgkins lymphoma. If a person suspects that they may be developing or have developed non-Hodgkins lymphoma, it is very important to seek a confirming medical diagnosis right away. Non-Hodgkins lymphoma can be an aggressive condition and the sooner treatment can be started, the better chance the individual has of beating the condition.. Because non-Hodgkins lymphoma primarily affects the lymphatic system, the most common symptom of non-Hodgkins lymphoma is swollen lymph nodes in the body. The swollen lymph nodes can occur in the neck, groin, collarbone ...
non-hodgkins lymphoma - MedHelps non-hodgkins lymphoma Center for Information, Symptoms, Resources, Treatments and Tools for non-hodgkins lymphoma. Find non-hodgkins lymphoma information, treatments for non-hodgkins lymphoma and non-hodgkins lymphoma symptoms.
Twelve patients with primary non-Hodgkins lymphomas of the CNS are described. Out of 5 CSF cytologies performed, 4 were positive. Radiotherapy was given to the tumour area in 3 patients, or to the whole brain in 5 patients. Four cases received radiotherapy to the spinal cord as well. Patients receiving ... read more whole CNS irradiation, including the spinal cord, seem to have a longer survival than patients with brain irradiation only. Out of the 5 patients with total brain irradiation, 2 showed a relapse in the spinal cord. It is suggested that therapy should be given not only to the tumour bearing areas, but should comprise the entire CNS. show less ...
The addition of radioimmunotherapy to chemotherapy for previouslyuntreated patients with non-follicular indolent non-Hodgkins lymphoma proved to be well tolerated and effective, producing a 100percent complete remission at the end of treatment. An estimated 89percent of patients remained in remission at three years, according toresults from a phase II clinical study, published in January issue of Cancer.
This information is about non-Hodgkin lymphoma, a cancer that starts in the immune system. Non-Hodgkin lymphoma is also called NHL.. Non-Hodgkin lymphoma begins when a lymphocyte (usually a B cell) becomes abnormal. The abnormal cell divides to make copies of itself. The new cells divide again and again, making more and more abnormal cells. The abnormal cells dont die when they should. They dont protect the body from infections or other diseases. The buildup of extra cells often forms a mass of tissue called a growth or tumor.. Because lymphatic tissue is in many parts of the body, Hodgkin lymphoma can start almost anywhere. Usually, its first found in a lymph node.. When lymphoma is found, the pathologist reports the type. There are many types of lymphoma. The most common types are diffuse large B-cell lymphoma and follicular lymphoma.. Lymphomas may be grouped by how quickly they are likely to grow:. ...
Overview. Non-Hodgkins lymphoma is the seventh most common cancer in men and women in the United States. According to the American Cancer Society, 74000 new cases of non-Hodgkins lymphoma are diagnosed each year in the US. Non-Hodgkins lymphoma originates in the lymphatic system of the body. The lymphatic system fights diseases throughout the body. In non-Hodgkins lymphoma, tumors develop from white blood cells called lymphocytes. Lymph tissue is found in many places throughout the body, so lymphomas can start almost anywhere. Non-Hodgkins lymphoma is more common than the other type of general lymphoma, Hodgkin lymphoma. The major sites of lymph tissue are:. ...
Non-Hodgkin Lymphoma, Read about Non-Hodgkin Lymphoma symptoms, causes, diagnosis, and treatment. Also read Non-Hodgkin Lymphoma articles about how to live with Non-Hodgkin Lymphoma, and more.
DEAR DR. ROACH: Have you heard that lymphoma patients are more likely than others to develop blood clots after surgery? I nearly died of a pulmonary embolus six days after hernia surgery. I have indolent non-Hodgkins lymphoma and never have had chemotherapy or radiation treatment. -- P.R.. ANSWER: People with many different types of cancers are at higher risk for blood clotting. Those with cancer of the pancreas, colon, stomach, lung, kidney or brain are among the highest risk. Blood cancers, like leukemia and lymphoma, also increase the risk of a blood clot. Surgery already increases blood clot risk, but cancer further increases the risk of blood clots. The combination of cancer, even an indolent lymphoma, and routine surgery imparts about a 6 percent risk of blood clots, which is high enough that routine anticoagulation certainly should be considered. People with cancer should have a discussion with their surgeon about anticoagulation around surgery.. DEAR DR. ROACH: Maybe you will be able to ...
Both Hodgkins lymphoma and non-Hodgkins lymphoma are lymphomas - a type of cancer that begins in a subset of white blood cells called lymphocytes. Lymphocytes are an integral part of your immune system, which protects you from germs.. The main difference between Hodgkins lymphoma and non-Hodgkins lymphoma is in the specific lymphocyte each involves.. A doctor can tell the difference between Hodgkins lymphoma and non-Hodgkins lymphoma by examining the cancer cells under a microscope. If in examining the cells, the doctor detects the presence of a specific type of abnormal cell called a Reed-Sternberg cell, the lymphoma is classified as Hodgkins. If the Reed-Sternberg cell is not present, the lymphoma is classified as non-Hodgkins.. Many subtypes of lymphoma exist, and your doctor will use laboratory tests to examine a sample of your lymphoma cells to determine your specific subtype. Expect to wait a few days to receive results from these specialized tests.. Your type of lymphoma helps ...
ORLANDO-Preliminary results of a French study show improved event-free survival for patients with indolent non-Hodgkins lymphoma (NHL) who received high-dose chemotherapy with purged autologous stem cell transplantation as first-line therapy, compared with conventional standard therapy. 1
A bispecific monoclonal antibody is made up of two different monoclonal antibodies that bind to two different substances and kills cancer cells. Bispecific monoclonal antibody therapy is used in the treatment of Burkitt and Burkitt-like lymphoma/leukemia and diffuse large B-cell lymphoma.. Tyrosine kinase inhibitors (TKIs) block signals that tumors need to grow. Some TKIs also keep tumors from growing by preventing the growth of new blood vessels to the tumors. Other types of kinase inhibitors, such as crizotinib, are being studied for childhood non-Hodgkin lymphoma.. Immunotoxins can bind to cancer cells and kill them. Denileukin diftitox is an immunotoxin used to treat cutaneous T-cell lymphoma.. Targeted therapy is being studied for the treatment of childhood non-Hodgkin lymphoma that has recurred (come back).. See Drugs Approved for Non-Hodgkin Lymphoma for more information.. Other drug therapy. Retinoids are drugs related to vitamin A. Retinoid therapy with bexarotene is used to treat ...
The Working formulation is an obsolete classification of non-Hodgkin lymphomas, first proposed in 1982. It has since been replaced by other lymphoma classifications, the latest published by the WHO in 2008, but is still used by cancer agencies for compilation of lymphoma statistics. Low Grade Malignant lymphoma, small lymphocytic (chronic lymphocytic leukemia) Malignant lymphoma, follicular, predominantly small cleaved cell Malignant lymphoma, follicular, mixed (small cleaved and large cell) Intermediate grade Malignant lymphoma, follicular, predominantly large cell Malignant lymphoma, diffuse, small cleaved cell Malignant lymphoma, diffuse, mixed small and large cell Malignant lymphoma, diffuse, large cell High grade Malignant lymphoma, large cell, immunoblastic Malignant lymphoma, lymphoblastic Malignant lymphoma, small noncleaved cells (Burkitt lymphoma) Miscellaneous Composite Mycosis fungoides Histiocytic Extramedullary plasmacytoma Unclassifiable MacKenzie RG, Rusthoven JJ (1985). ...
Roche has won European approval for cancer drug Gazyvaro as a treatment for some patients with previously treated follicular lymphoma, the most common type of indolent non-Hodgkins lymphoma. - News - PharmaTimes
According to a recently published study, people who drink alcohol may have a lower risk of developing a type of cancer which affects the lymphatic system known as non-Hodgkin lymphoma (NHL). related to Beer & cider, Spirits, Wine,
Learn more about Treatments for Non-Hodgkins Lymphoma at Reston Hospital Center Main Page Risk Factors ...
Learn more about Treatments for Non-Hodgkins Lymphoma at Memorial Hospital Main Page Risk Factors Symptoms ...
In this single-group study, idelalisib showed antitumor activity with an acceptable safety profile in patients with indolent non-Hodgkins lymphoma who had received extensive prior treatment. (Funded by Gilead Sciences and others; ClinicalTrials.gov number, NCT01282424.).
The use of high-dose chemotherapy and autologous hematopoietic blood or marrow transplantation for high-risk aggressive non-Hodgkin lymphoma has been extensively evaluated over the past few decades. This treatment was originally used only for patients with relapsed aggressive lymphoma. However, as the patients who were at higher risk for relapse could more easily be identified by clinical features and the technique became safer, it was used in some trials earlier in the course of the disease for higher-risk patients according to the International Prognostic Index (IPI).1. Prior to the addition of rituximab (Rituxan) to standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), several trials demonstrated an improvement when early transplantation was performed in first remission.2,3 However, there were also conflicting trials that did not demonstrate a benefit for early transplantation in this patient population.4,5 A meta-analysis of these earlier randomized trials demonstrated ...
Learn about non-hodgkins lymphoma clinical trials for those who are experiencing cancer recurrence from Cancer.com, a cancer information resource hub.
Members of Non-Hodgkins Lymphoma Support Group - Cancers. Discuss with people facing similar health challenges as yours. Seek advice from our online experts.
Non-Hodgkins Lymphoma Support Group - Cancers. Discuss with people facing similar health challenges as yours. Seek advice from our online experts.
Overview Of Global Non-Hodgkins Lymphoma Treatment Market In Covid-19 With Business Opportunities. The report named Global Non-Hodgkins Lymphoma Treatment Market report 2020 abbreviates some basic segments of the business. Non-Hodgkins Lymphoma Treatment Market current conditions, advertise demands and urgent business procedures that are picked by the business players and Non-Hodgkins Lymphoma Treatment Market improvement circumstance. The business procedures picked by players are examined in the Non-Hodgkins Lymphoma Treatment Market report dependent on driving players, item type, application and overall locales. When contrasted with the current market situation, the worldwide Non-Hodgkins Lymphoma Treatment Market report uncovers different realities identified with driving variables, patterns, openings, limitations, and significant Non-Hodgkins Lymphoma Treatment Market difficulties experienced by the market players.. Non-Hodgkins Lymphoma Treatment Market: Premier Players and their ...
RnRMarketResearch.com adds report B-Cell Non-Hodgkin Lymphoma Global Clinical Trials Review, H1, 2014 to its store.. B-Cell Non-Hodgkin Lymphoma Global Clinical Trials Review, H1, 2014. Summary. GlobalDatas clinical trial report, B-Cell Non-Hodgkin Lymphoma Global Clinical Trials Review, H1, 2014″ provides data on the B-Cell Non-Hodgkin Lymphoma clinical trial scenario. This report provides elemental information and data relating to the clinical trials on B-Cell Non-Hodgkin Lymphoma. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating B-Cell Non-Hodgkin Lymphoma. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis ...
The cytokine soluble CD23 (sCD23) has been shown to act as a B cell growth factor and to be elevated in serum prior to development of AIDS-related non-Hodgkins lymphoma (AIDS NHL). To further characterize the elevation of serum sCD23 in AIDS NHL patients and investigate its potential as a diagnostic test, a matched case-control study of AIDS NHL (n = 101) was nested within the Multicenter AIDS Cohort Study. Serum sCD23 was measured in cases and controls serum specimens at three different time periods (0-6, 6-12, and 12-18 months) and CD4+ thresholds (0-99, 100-199, and 200-299 cells/microl) prior to the cases NHL diagnosis. Changes in serum sCD23 over time were examined in AIDS NHL cases relative to controls, and t tests were performed to determine whether cases serum sCD23 exceeded that of controls at each time period and CD4+ threshold. Overall, cases median serum sCD23 levels were approximately double those of controls. Serum sCD23 concentration was positively correlated with lymphocyte counts
Can you still get life insurance if you have non-hodgkins lymphoma? While classifying this cancer is complex, we can help you find good rates TODAY.
immune Uncategorized PP121, Rabbit polyclonal to BMPR2 Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse cellular procedures including PP121 proliferation adhesion success and motility. III tests in individuals with advanced indolent non-Hodgkins lymphoma and mantle cell lymphoma. With this review we summarized the main substances of PI3K signaling pathway and talked about the preclinical versions and clinical tests of powerful small-molecule PI3K inhibitors. Intro Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that play central part in rules of cell routine apoptosis DNA restoration senescence angiogenesis mobile rate of metabolism and motility [1]. They become intermediate signaling substances PP121 and are renowned for their jobs in the PI3K/AKT/mTOR signaling pathway [2 3 PI3Ks transmit indicators through the cell surface towards the cytoplasm by producing second messengers - phosphorylated phosphatidylinositols - which activate multiple effector ...
Background: In 2008, non-Hodgkin lymphoma ranked tenth among other malignancies worldwide with an incidence of around 5 cases per 100,000 in both genders. The latest available rates in Tunisia are from 2006. Materials and Methods: This study aimed to provide an update about NHL incidence for 2009 and its trend between 1998 and 2009 as well as a projection until 2024, using data from the Salah Azaiz Institute hospital registry and the Noth Tunisia cancer registry. Results: In 2009, the NHL incidence in the north of Tunisia was 4.03 cases per 100,000, 4.97 for men and 3.10 for women. Diffuse large B-cell lymphoma (DLBCL) accounted for 63.2% of all NHL subtypes. Between 1998 and 2009, the overall trend showed no significant change. When we compared the trend between two periods (1998-2005 and 2005-2009), joinpoint regression showed a significant decrease of NHL incidence in the first period with an annual percentage change (APC) of -6.7% (95% CI:[-11.2%;-2%]), then the incidence significantly increased
Healthcare Sales & Marketing Network: Cephalon Submits New Drug Application for TREANDA for the Treatment of Patients with Relapsed Indolent Non-Hodgkins Lymphoma
In endometrioid cancer cases, the depth of myometrial invasion, the lymphovascular space invasion (LVSI) and the microcystic, elongated, and fragmented (MELF) glands type of invasion are predictors for a metastasis. Although the intermediate grade papillary endometrioid adenocarcinoma of the endometrium is currently not included in the latest classification of the tumors in the female reproductive system, its existence provokes an interest due to the necessity to perform differential diagnosis against other endometrioid tumors. Hereby presented is a case of papillary endometrioid carcinoma of intermediate grade with invasion in leiomyoma, expressed via LVSI and MELF syndrome with intact myometrium. Morphological and immunohistochemical algorithms have been performed.
Non-Hodgkin lymphoma treatment depends on the type of cancer you have, its stage, your health and your age. If only one lymph node is affected by the tumor, you can definitely be cured by radiotherapy. In advanced non-Hodgkins lymphoma, survival chance decreased considerably. In general, non-Hodgkins lymphoma treatment includes radiotherapy, chemotherapy, biotherapy, and other therapeutic methods such as stem cell transplantation.. Radiotherapy (Radiation therapy) Radiotherapy consists of using high doses of X-rays to kill cancer cells in order to eliminate or shrink the tumor. If the cancer is too advanced to be completely destroyed, radiation therapy can reduce symptoms and prolong your life. In the case of a non aggressive non-Hodgkin lymphoma, radiotherapy combined with chemotherapy can lead to a complete cure in about 50% of cases.. Chemotherapy Chemotherapy is the use of anticancer drugs to kill cancer cells and prevent metastases. Chemotherapy is often used to treat advanced non-Hodgkin ...
Rituximab is a monoclonal antibody approved for treatment of non-Hodgkin lymphomas that targets CD20, an antigen expressed by mature B cells. Single-agent rituximab treatment elicits clinical responses in many patients with non-Hodgkin lymphomas such as follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), but few treatment options are available for patients who relapse or are refractory to rituximab. Another B-cell antigen, CD22, which is expressed by the vast majority of B-cell cancers but not by lymphocyte precursors or memory B cells, also represents an attractive target for non-Hodgkin lymphoma therapy. Inotuzumab ozogamicin (INO) is a CD22-targeted therapy in which a humanized CD22 antibody is conjugated to calicheamicin, a cytotoxic antibiotic. In a multicenter open-label phase I/II study, Fayad and colleagues evaluated the combination of rituximab and inotuzumab ozogamicin (R-INO) in patients with relapsed FL, relapsed DLBCL, or refractory non-Hodgkin lymphomas. A ...
Non-Hodgkins lymphoma (NHL) remains the second most common malignant complication in patients with human immunodeficiency virus (HIV) infection. As we enter the third decade of the acquired immunodeficiency syndrome (AIDS) epidemic, it is apparent that the evolution of antiretroviral therapy and the emergence of combination antiviral strategies have greatly affected the natural history of HIV infection and its neoplastic complications. For example, there may be a trend for declining incidence of AIDS-related lymphoma in the United States for the first time. However, in regions of the world where the burden of HIV infection is greatest, such as in East Africa, AIDS-related lymphoma is an increasing cause of morbidity and mortality. Treatment of lymphoma has evolved coincident with improvements in antiretroviral therapy. Infusional chemotherapy regimens may offer advantages over other regimens and schedules, but comparative trials have not been done. Clinical trial data are available on which to ...
The Agricultural Health Study investigated the relationship between specific fungicides and pesticides and the development of Non-Hodgkin Lymphoma (NHL) in pesticide applicators, primarily farmers, from North Carolina and Iowa. In a recent article published in PLOS One, health information was analyzed from 54,306 participants enrolled in the study, including 523 applicators who were diagnosed with NHL between 1993 and 2010. Twenty-six different pesticides including insecticides, fungicides and fumigants were investigated to determine if exposure was linked to NHL incidence. Results suggest that exposure to pesticides from many different classes of chemicals was linked to an increased risk of NHL. This study is the first to find a correlation between exposure to the pesticides DDT, lindane, permethrin, diazinon and terbufos with specific types of Non-Hodgkin Lymphoma.. ...
Hillman, J, The amount of antibody needed to lyse gardner lymphosarcoma cells. Abstr. (1963). Subject Strain Bibliography 1963. 1186 ...
TY - JOUR. T1 - Role of radiotherapy for primary orbital lymphoma. AU - Lee, Sang Wook. AU - Suh, Chang Ok. AU - Kim, Gwi Eon. AU - Yang, Woo Ick. AU - Lee, Sang Yeul. AU - Hahn, Jee Sook. AU - Park, Joon Oh. PY - 2002/6/18. Y1 - 2002/6/18. N2 - To define the role of radiation therapy of primary orbital lymphoma, a retrospective analysis was undertaken for 18 patients with primary orbital lymphoma who were treated with curative radiotherapy between 1984 and 1995. The histology was found to be low grade lymphoma in 11 patients, intermediate grade in 7. All patients were of Ann Arbor stage IE, but bilateral involvement of the orbit was observed in 3 patients (16.6%). Anatomical subsites involved were the retrobulbar, eyelid, and conjunctiva in eight, five, and four patients, respectively. The median radiation dose was 30 Gy ranging from 20 Gy to 50 Gy. Twelve of 18 patients received a radiation dose of 30 Gy or less. To properly protect the lens during irradiation, the contact lens blocks were ...
Treatment varies depending on the exact type of B or T-cell lymphoma you have, where it has spread in your body and how fast it is likely to grow. Your age and your general health are also taken into account. When deciding how to treat your lymphoma it is important to know how fast it is likely to grow and cause problems in your body. This is called the grade of your lymphoma.. Some types of lymphoma grow slowly, cause few symptoms and may not need to be treated urgently. These are known as indolent lymphomas (also called low-grade lymphomas). Others grow more quickly, cause more severe symptoms and generally need to be treated soon after they are diagnosed. These are known as aggressive lymphomas (also called intermediate-grade and high-grade lymphomas).. Low-grade lymphomas (indolent). Many low-grade lymphomas take years to grow, cause few if any symptoms and do not necessarily need to be treated initially. In these cases the doctor may recommend regular checkups to carefully monitor your ...
Researchers affiliated with the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) have reported that conventional chemoimmunotherapy was superior to sequential high-dose chemotherapy with autologous stem cell support for the treatment of high-risk patients with aggressive B-cell lymphoma. The details of this randomized study were presented at the 2011 meeting of the American Society of Clinical Oncology.. Non-Hodgkins lymphoma (NHL) is a form of cancer that begins in the cells of the lymph system. The lymph system includes the spleen, thymus, tonsils, bone marrow, lymph nodes, and circulating immune cells. The main cells in the lymph system are lymphocytes, of which there are two types: B- and T-cells. Each cell type has a specific function in helping the body fight infection.. Non-Hodgkins lymphoma is characterized by the excessive accumulation of atypical (cancerous) lymphocytes. These lymphocytes can crowd the lymph system and suppress the formation and function of other immune ...
Fourteen-day CHOP supported with granulocyte colony-stimulating factor in patients with aggressive non-Hodgkins lymphoma: results of a phase II study.
Transformation is the evolution of an indolent lymphoma/leukemia to an aggressive lymphoma, typically harboring a very poor prognosis. This phenomenon is well described in humans , but under-estimated in dogs although recognized as a possible evolution of indolent lymphomas/leukemias. In canine chronic leukemias blast crisis (mainly in myeloid ) and Richter syndrome (transformation into a high grade lymphoma) (mainly in B-cell lymphocytic leukemia) has been reported. Transformation is a possible event also in canine low grade lymphomas, although rare. The increased knowledge has also generated new questions and posed challenges that need to be addressed to improve outcome, including the recognition of the clinical characteristics at diagnosis associated with a higher risk of transformation in an attempt of anticipating the typical evolution.
Lymphomas. Lymphoma is a type of cancer that originates in cells of the lymphatic system. There are many types of lymphomas; however, these tumors are commonly divided into two main categories: Hodgkins and Non-Hodgkins Lymphomas.. Lymphomas are curable if detected early and treatments are well tolerated. Historically, Non-Hodgkins Lymphomas were one of the first cancers cured with Radiation Therapy alone due to its radiation sensitivity.. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These sub-types behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.. Lymphomas Treatment. The management of lymphoma requires a multidisciplinary team as the efforts of the surgeon, the hematologist, and the radiation oncologist must interact in the management of ...
Species: Human Category: Cancer Tissue of Origin: B-cell / Plasma Cell Cancer Type: B-cell Non-Hodgkin Lymphoma Description SK-LY-18 is a human lymphoma cell line. Source This cell line was established from a B-cell in a person with lymphoma
Lymphomas are any cancers of the lymphatic tissues. They are distinguished/classified by the World Health Organization (WHO) system, using the latest information on the appearance and growth pattern of the lymphoma cells and genetic features, including whether or not it is a Hodgkin lymphoma, a T-cell or B-cell lymphoma, and the site from which the lymphoma arises.. Hodgkin lymphoma is marked by the presence of a type of cell called the Reed-Sternberg cell.. Non-Hodgkin lymphomas, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma. A wide variety of lymphomas are in this class, and the causes, the types of cells involved, and the prognosis vary by type. The incidence of non-Hodgkin lymphoma increases with age. It is further divided into several subtypes ...
Hoster, E, Dreyling, M, Klapper, W. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood. vol. 111. 2008. pp. 558(This analysis of outcome of 455 patients identified a new prognostic index predictive of survival in patients with advanced stage mantle cell lymphoma.). Determann, O, Hoster, E, Ott, G. Ki-67 predicts outcome in advanced-staged mantle cell lymphoma patients treated with anti-CD20 immunochemotherapy: results from randomized trials of the European MCL Network and the German Low Grade Lymphoma Study Group. Blood.. vol. 111. 2008. pp. 2385-7. (In this paper, the Ki-67 fraction was identified as an independent predictor of survival in MCL.). Herrmann, A, Hoster, E, Zwingers, T. Improvement of overall survival in advanced stage Mantle Cell Lymphoma. J Clin Oncol.. vol. 27. 2009. pp. 511(This paper demonstrated a significant improvement in the overall of patients with mantle cell lymphoma treated in the 1970 s and 80s compared to patients ...
Survivor: Non-Hodgkin Lymphoma (NHL) > B-Cell Lymphoma > Burkitt Lymphoma Patient Info: Finished active treatment more than 5 years ago, Diagnosed: almost 25 years ago, Female, Age: 54, Stage IV
CD19-specific chimeric antigen receptor (CAR)-modified T cells have antitumor activity in B cell malignancies, but factors that affect toxicity and efficacy have been difficult to define because of differences in lymphodepletion and heterogeneity of CAR-T cells administered to individual patients. We conducted a clinical trial in which CD19 CAR-T cells were manufactured from defined T cell subsets and administered in a 1:1 CD4+/CD8+ ratio of CAR-T cells to 32 adults with relapsed and/or refractory B cell non-Hodgkins lymphoma after cyclophosphamide (Cy)-based lymphodepletion chemotherapy with or without fludarabine (Flu). Patients who received Cy/Flu lymphodepletion had increased CAR-T cell expansion and persistence, and higher response rates [50% complete remission (CR), 72% overall response rate (ORR)] than patients who received Cy-based lymphodepletion without Flu (8% CR, 50% ORR). The CR rate in patients treated with Cy/Flu at the maximally tolerated dose was 64% (82% ORR; n = 11). Cy/Flu ...
INTRODUCTION Lymphomas are malignant neoplasms arisen from lymphocytes (B or T) that affect mainly lymph nodes, spleen, and other non-hematopoietic tissues. They are classified as Hodgkin´s lymphoma or non-Hodgkin´s lymphoma.1 Diffuse large B-cell lymphoma (DLBL) is the most common variant of non-Hodgkin´s intermediate-grade lymphomas, and frequently involves extranodal sites. Even though DLBL is characterized by an aggressive behavior, it responds favorably to chemotherapy.2 Non-Hodgkin´s lymphomas are usually manifested as localized or generalized lymphadenopathy. However, the primary lesion can occur in other sites, principally where lymphoid tissue is present such as oropharynx, intestine, bone marrow and skin.3 DLBL is often associated with systemic symptoms such as night sweats, weight loss and fever. In the oral soft tissues, lesions can occur as hard and diffuse tumors involving oral vestibule, gums and the posterior region of the hard palate. In bone tissue, they may cause mild ...
The flvi-2 locus is a target of insertional mutagenesis in thymic lymphosarcomas induced by feline leukemia virus (FeLV). flvi-2 encodes the gene bmi-1, whose product is implicated as a myc-collaborator in the induction of B- and T-cell lymphoma. We have examined the involvement of flvi -2 and myc in natural and experimentally induced FeLV-positive feline lymphosarcomas which are heterogeneous in anatomical origin, geographic origin, and strain of FeLV involved. We further compared these findings with previous reports of novel FeLV env genes in the same tumors. The results show that proviral insertion at flvi-2 occurs commonly in natural and experimental feline thymic lymphosarcomas of diverse origins [52% overall], and that alterations in c-myc commonly accompany insertional mutagenesis of flvi-2 [54% overall]. However, 46% of tumors with flvi-2 insertions apparently lack involvement of c-myc. These observations support the hypothesis that interruption of flvi-2 may be an early event in a ...
The treatment of non-Hodgkin lymphoma (NHL) patients has been recently informed by several important studies, which were discussed at the Best of ASCO Boston meeting by Michael E. Williams, MD, of the University of Virginia Cancer Center in Charlottesville.. Bendamustine Outperforms R-CHOP in NHL In a presentation at this years ASCO Annual Meeting Plenary Session, German investigators reported that in the phase III Study Group Indolent Lymphomas (StiL) NHL1 trial, the combination of bendamustine (Treanda) plus rituximab (Rituxan), or BR, more than doubled the median progression-free survival vs standard treatment with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) and proved more tolerable as well in patients with NHL.1 While B-R has been a recommended treatment option by the National Comprehensive Cancer Network since the initial study data were announced in 2009, many U.S. oncologists have not yet utilized the regimen.. The updated StiL NHL1 results will likely ...
Shop eye-catching Non-Hodgkins Lymphoma shirts, apparel and gifts featuring a variety of lime green ribbon designs created by cancer survivors who understand.
Shop eye-catching Non-Hodgkins Lymphoma shirts, apparel and gifts featuring a variety of lime green ribbon designs created by cancer survivors who understand.
Non-Hodgkins Lymphoma accounts for about four percent of all cancers in the United States, according to the American Cancer Society Cancer Treatment Centers of America American Cancer Society Enlarged lymph nodes Swollen abdomen (belly) Feeling full after only a small amount of food Chest pain or pressure Shortness of breath or cough Fever Weight loss Night sweats Fatigue (extreme tiredness) Low red blood cell counts (anemia) Non-Hodgkins lymphoma 1. Lymph nodes 2. Abdomen 3.
Hodgkins disease was the primary lymphoma to be defined as early as 1832 by Prof. Hodgkins. Over the years, non-Hodgkins lymphoma has become quite common. In the United States, it is estimated that 69,000 new cases and 19,000 deaths from non-Hodgkins lymphoma will occur yearly. It has not been pursued in detail as of now, and there are many points still in the dark.. Many doctors adopt a waiting policy where they inspect the patient patiently before coming to a practical conclusion. It is diagnosed (Understanding a Lymphoma Diagnosis) by biopsy through needle insertion. In severe manifestations, the whole part containing affected lymph nodes needs to be taken out. A combination treats it of radiation and chemotherapy. The logic is to retain the white blood cells to grow and multiply. Since it is an immune system-specific disease, immunotherapy or boosting the immune system is deemed the best antidote.. Stem cell transplant that has its precepts on DNA strands is also quite active but highly ...
Non Hodgkins Lymphoma (search for the word non hodgkin to pull up this testimonial). Hippocrates Health Institute Success Stories To learn more about their program, visit http://hippocratesinst.org/ View over 100 of their best success stories at https://itunes.apple.com/us/book/hippocrates-health-institute-success-stories/id1033283953?mt=11 - Non-Hodgkins Lymphoma - Sherrie Clark. ...
Follicular non-Hodgkins lymphoma. Biopsy of a left posterior auricular lymph node and pathology showed follicular non-Hodgkins lymphoma. Received six cycles
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Between January 2001 and December 2013, all patients (n= 19) that underwent surgical management for primary DLBL were identified from a retrospective database. All data of the clinical and pathological features were reviewed retrospectively. Gastrointestinal intestinal DLBL satisfied the lymphoma definition of Lewin et al. [7]. A total of 19 patients were included in this study, of which 69 were extranodal type of Non-Hodgkin lymphoma patients, 25 were gastrointestinal lymphoma and 21 were primary gastrointestinal DLBCL patients. Of these patients, a total of 19 patients were included in the study, excluding 2 patients who underwent palliative surgery during chemotherapy (Fig. 1). All patients underwent surgery and adjuvant chemotherapy using cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (CHOP) or rituximab CHOP (R-CHOP) regimens except postoperative mortality. All patients underwent gastroduodenoscopy, colonoscopy, and a biopsy, staging scans (computed tomography scan of the ...
Non-Hodgkin lymphomas (NHLs) in the head and neck region are malignant lymphoid neoplasms that usually originate from B-lymphocytic cell lines. Primary extranodal manifestations of this hematolymphoid tumor in the oral cavity are rare and involve the maxillary jaw including the palatal soft tissues, the mandible, and gingival tissues in patients between 60 and 70 years of age without sex predilection. This case report of an extra nodal NHL in the palate of a 75-year-old patient emphasizes the importance of accurate clinical, radiographic, and histologic diagnostic procedures to avoid delayed diagnosis or inappropriate treatment strategies. Chemotherapy, radiotherapy, or a combination of the two with a regular clinical and hemic follow-up is recommended. (Quintessence Int 2010;41:93 97 ...
Mantle-Cell Lymphoma: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin, somatic; 605027; RAD54L Lymphoproliferative syndrome, EBV- ... GNE Non-Hodgkin lymphoma, somatic; 605027; CASP10 Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in; 211980; ... HMGCS2 Hodgkin's lymphoma; 236000; KLHDC8B Holocarboxylase synthetase deficiency; 253270; HLCS Holoprosencephaly-2; 157170; ... RECQL4 Rapp-Hodgkin syndrome; 129400; TP63 Recombination rate QTL 1; 612042; RNF212 Refsum disease; 266500; PEX7 Refsum disease ...
"Non-Hodgkin's Lymphoma , Doctor , Patient". Patient. Retrieved 2016-03-11. "Primary biliary cirrhosis: MedlinePlus Medical ... In the case of lymphoma the treatment options include single-agent (or multi-agent) chemotherapy and regional radiotherapy, ... infections Hydatid cyst Leptospirosis Actinomycosis Metastatic tumours Hepatocellular carcinoma Myeloma Leukemia Lymphoma ...
Hodgkin's lymphoma and non-Hodgkin's lymphoma, throat cancer, prostate cancer, lung cancer, colon cancer, Ischemic heart ... non-Hodgkin lymphoma (NHL); Hodgkin disease; Chronic lymphocytic leukemia (CLL); including hairy cell leukemia and other ... Hodgkin's disease, non-Hodgkin's lymphoma, soft tissue sarcoma, chloracne, porphyria cutanea tarda, peripheral neuropathy, ... Hodgkin's lymphoma, and various kinds of cancer in exposed US military veterans. An epidemiological study done by the Centers ...
"Chemotherapy for Non-Hodgkin Lymphoma". cancer.org. American Cancer Society. May 31, 2016. Retrieved June 22, 2017. " ... "Chemotherapy for Hodgkin Lymphoma". cancer.org. American Cancer Society. March 29, 2017. Retrieved June 22, 2017. "Chemotherapy ... "Chemotherapy for Hodgkin Lymphoma". cancer.org. American Cancer Society. March 29, 2017. Retrieved June 22, 2017. " ... lymphomas, and childhood cancers, as well as several other types of cancer and some non-cancerous conditions. Vinblastine is a ...
It includes Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL): Hodgkin lymphoma (HL) Chemotherapy with ABVD or BEACOPP ... Non-Hodgkin lymphoma (NHL) Chemo-immunotherapy (R-CHOP) for B cell lymphomas, and chemotherapy (CHOP) for T cell lymphomas. ... "Prognostic value of B-symptoms in low-grade non-hodgkin's lymphomas". Leukemia & Lymphoma. 13 (3-4): 357-358. doi:10.3109/ ... Hande, K. R.; Garrow, G. C. (1993-02-01). "Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma". The ...
Thomas Hodgkin first describes abnormalities in the lymph system later known as Hodgkin's lymphoma. James Rennell's An ... Hodgkin Lymphoma (2nd ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 3-6. ISBN 978-0-7817-6422-3 ... "Brief Consideration of Thomas Hodgkin and His Times". In Hoppe, R. T.; Mauch, P. T.; Armitage, J. O.; Diehl, V.; Weiss, L. M. ( ... Hodgkin, T. (1832). "On some morbid experiences of the absorbent glands and spleen". Medico-Chirurgical Transactions. London. ...
Hjalgrim, H.; Engels, E. A. (2008). "Infectious aetiology of Hodgkin and non-Hodgkin lymphomas: a review of the epidemiological ... "Association between SV40 and non-Hodgkin's lymphoma". Leukemia & Lymphoma. 44 Suppl 3: S33-9. doi:10.1080/10428190310001623784 ... Mazzaro, C; Tirelli, U; Pozzato, G (2005). "Hepatitis C virus and non-Hodgkin's lymphoma 10 years later". Digestive and Liver ... Carbone, Antonino; Gloghini, Annunziata; Serraino, Diego; Spina, Michele (2009). "HIV-associated Hodgkin lymphoma". Current ...
Hodgkin's lymphoma (HL)Edit. Main article: Hodgkin's lymphoma. A study concluded, "The results of this large-scale European ... Non-Hodgkin lymphoma (NHL)Edit. Main article: Non-Hodgkin lymphoma. A study concluded, "People who drink alcoholic beverages ... September 2007). "Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma risk". American ... July 2005). "Alcohol consumption and risk of non-Hodgkin lymphoma: a pooled analysis". The Lancet Oncology. 6 (7): 469-76. doi: ...
On December 8, 2014, it was reported that a mass was discovered in Berry's chest and he was diagnosed with Hodgkin's lymphoma. ... Berry was diagnosed with Hodgkin's lymphoma on December 8, 2014. After going through chemotherapy in the offseason and being ... Teicher, Adam (December 8, 2014). "Eric Berry has Hodgkin's lymphoma". ESPN.com. Retrieved March 21, 2015. Rosenthal, Gregg ( ... Christopher Flowers, a lymphoma specialist at Emory University Hospital in Atlanta, said of Berry's diagnosis, "This is a ...
Transcriptional profiling of Hodgkin's Lymphoma; relationship to EBV status, histological subtype and geographical locale. ...
"Facts and Statistics: Hodgkin Lymphoma". Facts 2010-2011. USA: Leukemia and Lymphoma Society. 23 February 2011. Retrieved 7 ... Hodgkin's disease is a highly treatable, even curable, type of lymphoma; 96% of young patients survive at least five years ... refusal to allow him to receive chemotherapy for Hodgkin's lymphoma, the same disease at issue in Virginia v. Cherrix. The ... Cherrix was diagnosed with Hodgkin's disease in 2005 and underwent three months of chemotherapy, a standard medical treatment ...
He died of Hodgkin's lymphoma. Bromley was born on 1 February 1947 and named after his uncle Allan, who was killed in New ... In 1998, after a long spell of illness, he was diagnosed with Hodgkin's lymphoma. He met Anne Mitchell at that time and, on 15 ...
In Hodgkin's lymphoma, Reed-Sternberg cells harbor amplification of chromosome 9p24.1, which encodes PD-L1 and PD-L2 and leads ... "Nivolumab (Opdivo) for Hodgkin Lymphoma". U.S. Food and Drug Administration (FDA). 17 May 2016. "FDA grants regular approval to ... The evidence is very uncertain about the effect of Nivolumab for patients with a Hodgkin's lymphoma on the overall survival, ... In May 2016, the FDA approved nivolumab for the treatment of patients with classical Hodgkin lymphoma (cHL) who have relapsed ...
Hodgkin's lymphoma. 86.4% Non-Hodgkin's lymphoma. 71% Thyroid cancer. 98.2% Leukemia (Acute lymphocytic). 68.2% ...
... and other High grade non-Hodgkin lymphomas Hodgkin lymphoma Low-grade non-Hodgkin lymphoma Myelodysplastic syndromes (MDS) The ... "High Grade non-Hodgkin Lymphoma" (PDF). Blood Cancer UK. Retrieved 5 April 2020. "Hodgkin lumphoma" (PDF). Blood Cancer UK. ... "Low-grade non-Hodgkin lymphoma" (PDF). Blood Cancer UK. Retrieved 5 April 2020. "Myelodysplastic syndromes (MDS)" (PDF). Blood ... In 2010 the charity renamed itself Leukaemia and Lymphoma Research, and in 2015 it became Bloodwise. In November 2019 the ...
This includes to treat melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, and stomach cancer. It is given by slow ... the treatment of adults with relapsed or refractory classical Hodgkin lymphoma (cHL) who have failed autologous stem cell ... "Pembrolizumab (Keytruda) for classical Hodgkin lymphoma". U.S. Food and Drug Administration (FDA). 14 March 2017. Retrieved 12 ... for the treatment of adult and pediatric patients with refractory classic Hodgkin's lymphoma (cHL), and recurrent locally ...
... and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma. CD30 is the target of the FDA approved ... Scott LJ (March 2017). "Brentuximab Vedotin: A Review in CD30-Positive Hodgkin Lymphoma". Drugs. 77 (4): 435-445. doi:10.1007/ ... Horie R, Higashihara M, Watanabe T (Jan 2003). "Hodgkin's lymphoma and CD30 signal transduction". International Journal of ... of CD30-positive B cell lymphomas Various types of CD30-positive T cell lymphomas CD30-positive cases of the NK cell lymphoma, ...
"Ross Hutchins diagnosed with Hodgkin's lymphoma". BBC Sport. 6 January 2013. Retrieved 20 April 2013. "2013 Australian Open - ... Marsden Cancer Charity after his best friend and fellow British player Ross Hutchins was diagnosed with Hodgkin's lymphoma. The ...
Alex Fields battles Non-Hodgkin's lymphoma. The documentary not only reveals the personal lives of the children, but shows ... He was recently diagnosed with non-Hodgkin's lymphoma, which was originally misdiagnosed by doctors as asthma. His first ... Timothy Woods is diagnosed with Hodgkin's lymphoma while Alexandra Lougheed, Justin Ashcraft, and Jennifer Moone are diagnosed ... It is explained that Tim was diagnosed with Hodgkin's lymphoma, a cancer of the lymph node glands. His symptoms, which were ...
The most common cancers are non-Hodgkin's lymphoma and skin cancers. The risk appears to be related to the intensity and ... "Key Statistics for Non-Hodgkin Lymphoma". www.cancer.org. Retrieved 19 February 2020. Hanifin JM, Paller AS, Eichenfield L, ...
Hutchins was diagnosed with Hodgkin's lymphoma in late 2012, which was treated and went into remission by July 2013. At the ... Ross Hutchins was diagnosed with Hodgkin's lymphoma in December 2012, and took an indefinite break from tennis while he ... "Ross Hutchins diagnosed with Hodgkin's lymphoma". BBC Sport. 6 January 2013. "Ross Hutchins' cancer in remission". ESPN. 22 ...
"Kleybanova has Hodgkin's lymphoma, a cancer".. ... but was unable to compete due to Hodgkins Lymphoma. María José ...
MabThera (rituximab), for B-cell chronic lymphocytic leukemia (and other hematological malignancies), non-Hodgkin lymphomas and ... Rituxan (rituximab), for non-Hodgkin's lymphoma. Rocaltrol (calcitriol), for osteoporosis and hypocalcaemia. Rocephin ( ... Polivy (polatuzumab vedotin), for diffuse large B-cell lymphoma. Protropin (somatrem), for growth hormone deficiency, later ...
In Hodgkin lymphoma and natural killer T-cell lymphoma, response rates are high, at 50-60%. Response rates are quite low for ... These include aggressive and indolent lymphomas such as diffuse large B-cell lymphoma and follicular lymphoma and leukemias ... Plosker GL, Figgitt DP (2003). "Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia". ... "Pembrolizumab (KEYTRUDA) for classical Hodgkin lymphoma". FDA. 9 February 2019. "FDA approves pembrolizumab for Merkel cell ...
In December, Ross Hutchins was diagnosed with Hodgkin's lymphoma, and took an indefinite break from tennis while he recovered. ... In September, Ross Hutchins decided to quit the Tour, soon after his return following treatment for Hodgkin's Lymphoma. That ... "Ross Hutchins diagnosed with Hodgkin's lymphoma". BBC Sport. 6 January 2013. "Jonny Marray and Colin Fleming lift Britain in ...
The scan reveals non-Hodgkin lymphoma. Anya's fear of her mother's death initially leads her to skip a family medical ...
"China Approves Tyvyt For Hodgkin's Lymphoma". Asian Scientist Magazine. Apr 20, 2017. Retrieved January 9, 2019. Ansell, S. M ... Another effective immune checkpoint inhibitor in classical Hodgkin lymphoma". The Lancet. Haematology. 6 (1): e2-e3. doi: ... by the National Medical Products Administration for marketing in China for relapsed or refractory classical Hodgkin's lymphoma ...
The cause was non-Hodgkin's lymphoma. He was 71 and lived on the Upper West Side. His marriages to Rachel Aubrey Rustow, a ...
Treatment results with Siltuximab in B-cell non-Hodgkin's lymphoma are inferior to those obtained in multicentric Castleman ... A focus in non Hodgkin lymphoma". Expert Opinion on Investigational Drugs. 26 (3): 367-373. doi:10.1080/13543784.2017.1288213. ...
EBV has also been implicated in several other diseases, including Burkitt's lymphoma, Hodgkin's lymphoma, stomach cancer, ... Epstein-Barr virus-positive Hodgkin lymphoma, and primary effusion lymphoma. The Epstein-Barr virus has been implicated in ... Gandhi MK, Tellam JT, Khanna R (May 2004). "Epstein-Barr virus-associated Hodgkin's lymphoma". British Journal of Haematology. ... and Hodgkin's lymphoma; non-lymphoid malignancies such as gastric cancer and nasopharyngeal carcinoma; and conditions ...
... particularly in Hodgkin's lymphoma, non-Hodgkin lymphoma, and lung cancer.[citation needed] ...
... including non-Hodgkin's lymphoma and lymphocyte predominant subtype, of Hodgkin's Lymphoma.[12] ... "Chronic Hepatitis After Hepatitis E Virus Infection in a Patient With Non-Hodgkin Lymphoma Taking Rituximab" (PDF). Retrieved ... "Rituximab in Hodgkin lymphoma: Is the target always a hit?". Cancer Treat Rev. 37 (5): 385-90. doi:10.1016/j.ctrv.2010.11.005. ... A monoclonal antibody for B cell non Hodgkin lymphoma and other affections". Crit Rev Oncol Hematol. 97: 275-290. doi:10.1016/j ...
... lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott- ... conditioning in patients with CNS involvement by non-Hodgkin lymphoma". Biol Blood Marrow Transplant. 18 (1): 76-83. doi: ... Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League ... These advantages have established autologous HSCT as one of the standard second-line treatments for such diseases as lymphoma.[ ...
... including non-Hodgkin's lymphoma and lymphocyte predominant subtype, of Hodgkin's Lymphoma.[12] This also includes ... Scott, Shane D. (1998). "Rituximab: A New Therapeutic Monoclonal Antibody for Non-Hodgkin's Lymphoma". Cancer Practice. 6 (3): ... "Rituximab in Hodgkin lymphoma: Is the target always a hit?". Cancer Treat Rev. 37 (5): 385-90. doi:10.1016/j.ctrv.2010.11.005. ... A monoclonal antibody for B cell non Hodgkin lymphoma and other affections". Crit Rev Oncol Hematol. 97: 275-290. doi:10.1016/j ...
Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...
Non-Hodgkin lymphoma. O. *Oncogene. *Oncology. *Oral cancer. *Oropharyngeal cancer. *Ovarian cancer ...
... non-Hodgkin's lymphoma (NHL) - non-nucleoside reverse transcriptase inhibitors (NNRTI) - non-steroidal anti-inflammatory drugs ... B-cell lymphoma - B cells - B lymphocytes (B cells) - bactericidal - bacteriostatic - bacterium - baculovirus - baseline - ... Hodgkin's disease - holistic medicine - homology (biology) - hormone - host - host factors - HPTN - HPV - HRSA - HTLV-I - HTLV- ...
"Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to ...
... with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma". ... particularly some types of non-Hodgkin's lymphoma.[108] Clinical results also seem to justify use of proteasome inhibitor ... Schenkein D (June 2002). "Proteasome inhibitors in the treatment of B-cell malignancies". Clinical Lymphoma. 3 (1): 49-55. doi: ... Lymphoma (TACL) Study". Blood. 120 (2): 285-90. doi:10.1182/blood-2012-04-418640. PMID 22653976.. ...
... is a medication used to treat cancer.[1] This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer ... Bleomycin is mostly used to treat cancer.[1] This includes testicular cancer, ovarian cancer, and Hodgkin's disease, and less ... Therefore, bleomycin is used in combination with doxorubicin in Hodgkins lymphoma, as they have additive and complementary ... commonly non-Hodgkin's disease.[1] It can be given intravenously, by intramuscular injection, or under the skin.[1] ...
states that he died of Hodgkin's disease, complicated with uremia, on November 1, 1955. ... Deaths from lymphoma. *Male biographers. *People from Maryville, Missouri. *People from Belton, Missouri ...
Fda Approves First Radiopharmaceutical Product To Treat Non-Hodgkin'S Lymphoma Archived January 19, 2009, at the Wayback ... Lymphoma may be radically curable if it is localised to one area of the body. Similarly, many of the common, moderately ... For curative cases, the typical dose for a solid epithelial tumor ranges from 60 to 80 Gy, while lymphomas are treated with 20 ... These include leukemias, most lymphomas and germ cell tumors. The majority of epithelial cancers are only moderately ...
MALT lymphoma, Waldenström macroglobulinemia, lupus erythematosus, Hodgkin's lymphoma, myelodysplastic syndrome and more. ... Orphan indications include diffuse large B-cell lymphoma, chronic lymphocytic leukemia and mantle cell lymphoma. Lenalidomide ... phase II trial observed efficacy in treating Non-Hodgkin's lymphoma. Pomalidomide (3-aminothalidomide) was the second ... Some of these indications include acute myeloid leukemia, follicular lymphoma, ...
Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH). *Anaplastic large-cell lymphoma t(2 ALK;5 NPM1) ... Rapp-Hodgkin syndrome/Hay-Wells syndrome. Elastic/Connective. *Ehlers-Danlos syndromes. *Cutis laxa (Gerodermia ...
The next most common is primary intraocular lymphoma (PIOL) which is usually non-Hodgkin's, large cell lymphoma of the B-cell ... The most common orbital malignancy is orbital lymphoma. This tumor can be diagnosed by biopsy with histopathologic and ... "Lymphoma of the Conjunctiva - The Eye Cancer Network". Retrieved 2010-03-10.. ... Most patients with orbital lymphoma can be offered chemotherapy or radiation therapy. ...
1960s - Developed an effective combination drug regimen for Hodgkin's lymphoma.. *1960s - Discovery that tooth decay is caused ...
Articles link the development of some forms of cancer (including leukemia, non-Hodgkin's lymphoma, bladder cancer, blood cancer ... "Hair Dye Linked to Blood Cancer: Long-Term Use of Dark, Permanent Dye May Raise Lymphoma Risk". Web MD. Retrieved 2007-07-29 ...
... including a twofold to fourfold increased risk of non-Hodgkin's lymphoma and a more than 30-fold increased risk of small ...
B21.2) HIV disease resulting in other types of non-Hodgkin's lymphoma ... B21.1) HIV disease resulting in Burkitt's lymphoma. *( ...
Carr had previously battled Hodgkin's lymphoma, and reported developing his hoarse speaking voice during his coverage of the ...
"Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma". Cancer. 67 (9): 2262-8. doi:10.1002/ ... Leukemia, lymphoma and multiple myeloma, 1950-1987". Radiation Research. 137 (2 Suppl): S68-97. Bibcode:1994RadR..137S..68P. ... Infectious mononucleosis, acute myeloid leukemia, lymphoblastic lymphoma, aplastic anemia[3]. Treatment. Chemotherapy, stem ... August 2005). "Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas". ...
Mulatero P, Rabbia F, Veglio F. "Paraneoplastic hyperaldosteronism associated with non-Hodgkin's lymphoma.", New England ... a lymphoma). Sometimes, the symptoms of paraneoplastic syndromes show before the diagnosis of a malignancy, which has been ...
Non-Hodgkin lymphoma (which is also known as B-cell and T-cell lymphomas) is a cancer of the lymphatic system. The lymphatic ... The most common symptom of non-Hodgkin lymphoma is a painless swelling in a lymph node, usually in the neck, armpit or groin. ... The usual way to know that a person has non-Hodgkin lymphoma is to do a biopsy (testing a sample of affected lymph node tissue ... In lymphoma, these lymphocytes start to multiply in an abnormal way. A lot of them appear in certain parts of the lymphatic ...
On May 30, 2007, Andruzzi was diagnosed with non-Hodgkin's Burkitt's lymphoma, predicted to double in size in just 24 hours.[1] ...
Non-Hodgkin's lymphoma. Cyclophosphamide, doxorubicin, vincristine, prednisolone. CHOP. Germ cell tumor. Bleomycin, etoposide, ... granted accelerated approval for the treatment of refractory Hodgkin's lymphoma and systemic anaplastic large cell lymphoma.[ ... such as acute myelogenous leukemia and the aggressive lymphomas, including Hodgkin's disease) are more sensitive to ... Hodgkin's disease. Mustine, vincristine, procarbazine, prednisolone. MOPP. Doxorubicin, bleomycin, vinblastine, dacarbazine. ...
Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ... of all cases of lymphomas in HIV infections (other types are Burkitt's lymphomas and immunoblastic lymphomas). Primary CNS ... Brain magnetic resonance imaging showing primary central nervous system B-cell non-Hodgkin lymphoma of the sella turcica and ...
... for use against non-Hodgkin's lymphoma, myelodysplastic syndromes, and multiple myeloma with AstraZeneca receiving $450 million ...
In easily cured forms of cancer, such as childhood leukemias, testicular cancer and Hodgkin lymphoma, cure rates may approach ...
... grant for translational research studies for Hodgkin and non-Hodgkin lymphoma - Five-year, $11.5 million.[18] ... California Institute for Regenerative Medicine (CIRM) grants for AIDS-related lymphoma and brain cancer research - $32.5 ... lymphoma, and diabetes. City of Hope has been designated a Comprehensive Cancer Center by the National Cancer Institute, a ...
AIDS-related Lymphoma. Childhood Non-Hodgkins Lymphoma. Cutaneous T-Cell Lymphoma. Primary Bone Lymphoma. Primary CNS Lymphoma ... PubMed Central search for free-access publications about Non-Hodgkin Lymphoma. MeSH term: Lymphoma, Non-Hodgkin. US National ... Primary bone lymphoma and primary adrenal lymphoma are rare clinicopathological entities of non-Hodgkins lymphoma (NHL). We ... BACKGROUND: Canine B-cell lymphoma is deemed an ideal model of human non-Hodgkins lymphoma where the lymphomas of both species ...
There are two major types of Hodgkin lymphoma: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma.[ ... Hodgkins lymphoma can be sub-classified by histological type. The cell histology in Hodgkins lymphoma is not as important as ... Hodgkins lymphoma was first described in an 1832 report by Thomas Hodgkin, although Hodgkin noted that perhaps the earliest ... Hodgkins Lymphoma at the American National Cancer Institute. *Clinically reviewed Hodgkins lymphoma information for patients ...
Although cancer can seem scary, most teens who get Hodgkins disease get better. ... Hodgkins disease is a type of lymphoma, which is a cancer of the lymphatic system. ... Hodgkin Lymphoma. Resources. Please Note: By clicking a link to any resource listed on this page, you will be leaving the ... The Societys mission is to cure leukemia, lymphoma, Hodgkins disease, and myeloma, and to improve the quality of life of ...
The different types of lymphomas are grouped into two broad categories: Hodgkin lymphoma and non-Hodgkin lymphoma. Lymphomas ... Hodgkin Lymphoma. Hodgkin lymphoma is a type of cancer that affects the lymphatic system. This highly sophisticated filtering ... Lymphomas without Reed-Sternberg cells are usually classified as non-Hodgkin lymphomas. ... If Hodgkin lymphoma is suspected, one of these biopsies may be done:. *Core biopsy: the doctor uses a hollow needle to remove a ...
Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkins lymphomas.[1] ... Less aggressive non-Hodgkin lymphomas are compatible with a long survival while more aggressive non-Hodgkin lymphomas can be ... To this day, lymphoma statistics are compiled as Hodgkins versus non-Hodgkin lymphomas by major cancer agencies, including the ... Patient information on non-Hodgkin lymphoma from The Lymphoma Association. *Lymphoma Association - Specialist UK charity ...
... which is absent in non-Hodgkin lymphoma cells. See also ,b>Hodgkin disease,/b>, ,b>immune system,/b>, ,b>lymphatic system,/b>. ... The difference between non-Hodgkin lymphoma and Hodgkin disease is the Reed-Sternberg cell,i>,,/i> ... non-Hodgkins lymphoma,/b>. A cancer of the,i> ,/i>lymphatic system (a network of thin vessels and nodes throughout the body ... non-Hodgkin lymphoma. Phonetic. Description. formerly called non-Hodgkins lymphoma. A cancer of the lymphatic system (a ...
Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the ... Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the ... non-Hodgkin lymphoma. Go to external page http://purl.obolibrary.org/obo/MONDO_0018908 Copy ...
... and management of Hodgkins lymphoma, with an emphasis on external beam radiotherapy technique and published evidence. ... Dose escalation of BEACOPP chemotherapy for advanced Hodgkins disease in the HD9 trial of the German Hodgkins Lymphoma Study ... Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the International Lymphoma Radiation Oncology ... results of the German Hodgkins Lymphoma Study Group (GHSG) trial HD7. Leuk Lymphoma. 2002;43(Suppl 2):52.Google Scholar ...
Visit the Lymphoma Research Foundations dedicated website for people with Hodgkin lymphoma, www.FocusOnHL.org, for additional ... Hodgkin Lymphoma with Dr. Sonali M. Smith , Everything You Need to Know - Duration: 10:00. Lymphoma Research Foundation 923 ... Visit the Lymphoma Research Foundations dedicated website for people with Hodgkin lymphoma, www.FocusOnHL.org, for additional ... T-Cell Lymphoma with Barbara Pro, MD , Everything You Need to Know - Duration: 7:31. Lymphoma Research Foundation 636 views ...
If you are facing non-Hodgkin lymphoma, we can help you learn about the treatment options and possible side effects, and point ... How is non-Hodgkin lymphoma treated?. Depending on the type and stage (extent) of the lymphoma and other factors, treatment ... Who treats non-Hodgkin lymphoma?. Based on your treatment options, you may have different types of doctors on your treatment ... If youve been diagnosed with non-Hodgkin lymphoma, your treatment team will discuss your options with you. Its important to ...
Recent developments in the therapy of non-Hodgkin lymphoma have improved response and survival rates in patients with these ... prognostic factors and novel targets of non-Hodgkin lymphoma. We believe that understanding the pathophysiology of non-Hodgkin ... Recent developments in the therapy of non-Hodgkin lymphoma have improved response and survival rates in patients with these ... for medical and healthcare professionals involved in the research and clinical care of patients with non-Hodgkin lymphoma. ...
The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin. The swelling is usually painless, ... However, its highly unlikely that you have Hodgkin lymphoma if you have swollen lymph nodes, as these glands often swell as a ... The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin. The swelling is usually painless, ... While the symptoms are unlikely to be caused by Hodgkin lymphoma, it is best to get them checked out. ...
Hodgkins Disease Info Stem Cell Transplants Thank You Page (coming soon) Photo Gallery (coming soon) Home Trouble is part of ... They list Hodgkins as oncology, even though it really is hematology.) January 23, 2004 ESHAP day 1 of 5 The new PICC catheter ... I called another Hodgkins patients mother. They live in West Virginia. She had sent me her number when she found out that ... We read it and need to return it to you.) What he had is treated sort of like Hodgkins. He had some of the same chemos that ...
Most kids and teens who get Hodgkin lymphoma get better. ... Hodgkin lymphoma is a type of cancer that affects the lymphatic ... Linfoma de Hodgkin. What Is Hodgkin Lymphoma?. Hodgkin lymphoma is a type of cancer. It develops in white blood cells in the ... These large cancer cells are not seen in other lymphomas.. Who Gets Hodgkin Lymphoma?. Hodgkin lymphoma can happen at any age. ... What Are the Risk Factors for Hodgkin Lymphoma?. Hodgkin lymphoma is caused by a mutation (a change in a gene) in the DNA of ...
... or Hodgkins disease (HD), is a blood cancer that starts in the lymphatic system. There are two main types of lymphoma. ... one is Hodgkin lymphoma and the other is non-Hodgkin lymphoma. The difference between Hodgkin lymphoma and non-Hodgkin lymphoma ... Classic Hodgkin lymphoma has four subtypes:. *Nodular sclerosis Hodgkin lymphoma (NSCHL): the most common type of Hodgkin ... then the lymphoma is categorized as non-Hodgkin lymphoma.. According to Healthline, Hodgkin lymphoma is most likely to occur in ...
Hodgkin lymphoma is a cancer of lymph tissue. Lymph tissue is found in the lymph nodes, spleen, liver, bone marrow, and other ... The cause of Hodgkin lymphoma is not known. Hodgkin lymphoma is most common among people 15 to 35 years old and 50 to 70 years ... Adult Hodgkin lymphoma treatment (PDQ) - health professional version. www.cancer.gov/types/lymphoma/hp/adult-hodgkin-treatment- ... Childhood Hodgkin lymphoma treatment (PDQ) - health professional version. www.cancer.gov/types/lymphoma/hp/child-hodgkin- ...
Hodgkin disease, Hodgkin lymphoma, Hodgkins sarcoma, Hodgkins lymphoma, stage I Subdiaphragmatic Hodgkin Lymphoma, stage II ... Hodgkins lymphoma, โรคฮอด์จกิน, มะเร็งต่อมน้ำเหลืองชนิดฮอด์จกิน (th); Хвороба Ходжкіна (uk); Hodgkins lymphoma, Hodgkins ... Hodgkins lymphoma, Hodgkins, Hodgkins disease, ہاجکنز ڈیزیز, ہاجکنز لمفوما (ur); Paltauf-Sternberg-Krankheit, Hodgkin- ... limfomul Hodgkin (ro); Hodgkins lymphoma (tl); Hoçkin hastalığı, Hodgkins disease
Non-Hodgkins lymphoma isnt one cancer, but a whole group of them. Learn the most common kinds, and the signs that you might ... for Non-Hodgkin Lymphoma," "Tests for Non-Hodgkin Lymphoma," "Treating B-Cell Non-Hodgkin Lymphoma," "Types of B-Cell Lymphoma ... "Peripheral T-cell Lymphoma.". Lymphoma Research Foundation: "Peripheral T-Cell Lymphoma," "Understanding Non-Hodgkin Lymphoma." ... "Anaplastic Large Cell Lymphoma," "Diffuse Large B-Cell Lymphoma," "Follicular Lymphoma," "Mantle Cell Lymphoma," "Non-Hodgkin ...
Hodgkins lymphoma is a rare cancer of the lymphatic system that affects groups of lymph nodes, such as those found in the neck ... which are referred to as non-Hodgkins lymphoma.. Although Hodgkins lymphoma can occur at any age, it is most likely to affect ... Hodgkins lymphoma is a rare cancer of the lymphatic system that affects groups of lymph nodes, such as those found in the neck ... The cause of Hodgkins lymphoma is not yet understood and the majority of patients who develop this condition do not have risk ...
Hodgkin disease is a type of lymphoma, cancer of the lymph system. It is a rare; but serious condition. Can cause swelling in ... Stages of Adult Hodgkin Lymphoma (National Cancer Institute) Also in Spanish * Stages of Childhood Hodgkin Lymphoma (National ... Whats the Difference between Hodgkins Lymphoma and Non-Hodgkins Lymphoma? (Mayo Foundation for Medical Education and ... Adult Hodgkin Lymphoma) (National Cancer Institute) * Treatment Option Overview (Childhood Hodgkin Lymphoma) (National Cancer ...
Non-Hodgkin lymphoma is caused by a change (mutation) in the DNA of a type of white blood cell called lymphocytes, although the ... Causes of non-Hodgkin lymphoma Non-Hodgkin lymphoma is caused by a change (mutation) in the DNA of a type of white blood cell ... Non-Hodgkin lymphoma can occur at any age, but most cases are diagnosed in people over 65. The condition is slightly more ... Non-Hodgkin lymphoma isnt infectious and isnt thought to run in families, although your risk may be slightly increased if a ...
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, a cancer that begins in certain immune ... A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back ... Investigational CAR-T therapy for Hodgkin lymphoma receives fast-track designation from FDA Based on proof-of-concept results ... Study examines racial disparities in survival outcomes of pediatric patients with Hodgkin lymphoma In what is believed to be ...
... is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma," Journal of Experimental Medicine, vol ... Hodgkins lymphoma (HL) is now basically considered to be a germinal centre-related B-cell lymphoma. Notably, significant ... with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma," in WHO Classification of ... and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma," Blood, ...
Hodgkin disease) is a potentially curable lymphoma with distinct histology, biologic behavior, and clinical characteristics. ... Hodgkin Lymphoma) and Hodgkin Lymphoma What to Read Next on Medscape. Related Conditions and Diseases. * Hodgkin Lymphoma ... Non-Hodgkin lymphoma, particularly diffuse large B cell lymphoma and anaplastic large cell lymphoma, both of which may have ... Treating limited-stage nodular lymphocyte predominant Hodgkin lymphoma similarly to classical Hodgkin lymphoma with ABVD may ...
AIDS-associated non-Hodgkin lymphoma.. Roithmann S, Tourani JM, Andrieu JM.. Comment on. *AIDS-associated non-Hodgkin lymphoma. ...
... including special clinical situations such as Hodgkin lymphoma in children, ... This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the ... This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the ... First and only book that covers ALL aspects of radiotherapy in Hodgkin lymphoma ...
Hodgkin lymphoma is a type of cancer that affects a persons lymphatic system. It can be aggressive, but there are many ... Nodular lymphocyte predominant Hodgkin lymphoma. About 5% of Hodgkin lymphoma cases are nodular lymphocyte predominant Hodgkin ... With treatment, Hodgkin lymphoma has a high cure and survival rate.. In this article, we discuss Hodgkin lymphoma, including ... There are two major types of Hodgkin lymphoma:. CHL At least 90% of Hodgkin lymphoma cases are CHL. This type of cancer occurs ...
In general, lymphomas are divided into 2 large groups of neoplasms, namely non-Hodgkin lymphoma (NHL) and Hodgkin disease. ... The term lymphoma describes a heterogeneous group of malignancies with different biology and prognosis. ... encoded search term (Non-Hodgkin Lymphoma) and Non-Hodgkin Lymphoma What to Read Next on Medscape. Related Conditions and ... A predictive model for aggressive non-Hodgkins lymphoma. The International Non-Hodgkins Lymphoma Prognostic Factors Project. ...
Bob Kaufman beat stage IV non-Hodgkin Lymphoma with a stem-cell transplant, and now hes giving back by sharing his story in ... Life After Non-Hodgkin Lymphoma. Bob focused on one thing during his fight with non-Hodgkin Lymphoma: Getting back to a normal ... Thats when he was diagnosed with stage IV non-Hodgkin Lymphoma. After chemo treatments, the non-Hodgkin Lymphoma returned. His ... I lost my brother to non Hodgkin Lymphoma in Dec. 2009 after he had a stem cell transplant earlier that year. It bought him ...
Hodgkins Lymphoma Hodgkins lymphoma is a type of cancer in the lymphatic system. Hodgkins lymphoma causes the cells in the ... Hodgkins lymphoma is a type of cancer in the lymphatic system. Hodgkins lymphoma causes the cells in the lymphatic system to ... Hodgkins disease is distinguished from other types of lymphomas by the presence of a particular type of diseased cell, called ... Hodgkins disease is distinguished from other types of lymphomas by the presence of a particular type of diseased cell, called ...
  • The stage at diagnosis can help medical professionals choose the best therapy and predict how someone with lymphoma will do in the long term. (kidshealth.org)
  • Visit the Lymphoma Research Foundation's dedicated website for people with Hodgkin lymphoma, www.FocusOnHL.org, for additional information on Hodgkin lymphoma diagnosis, treatment options, and clinical trials. (youtube.com)
  • However, histology experts do agree that the Reed-Sternberg cells or a variant of these cells needs to be identified in a biopsy in order for a diagnosis of Hodgkin's lymphoma to be confirmed. (news-medical.net)
  • Hodgkin lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (medscape.com)
  • Thus, the diagnosis of non-Hodgkin lymphoma (NHL) relies on pathological confirmation following appropriate tissue biopsy. (medscape.com)
  • Low- grade lymphoma can usually be managed and controlled effectively and the earlier the diagnosis the better the chance of survival. (medic8.com)
  • Living with non-Hodgkin's lymphoma can be extremely difficult and you may feel angry, upset and confused all at the same time, as you struggle to come to accept your diagnosis. (medic8.com)
  • During diagnosis - When diagnosing lymphoma, it's typically ideal to examine an entire lymph node for signs of cancer. (moffitt.org)
  • See 'Clinical manifestations, pathologic features, and diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma' . (uptodate.com)
  • After the diagnosis of NLPHL is confirmed, the patient should undergo a work-up and staging evaluation similar to that performed for patients with classical Hodgkin lymphomas. (uptodate.com)
  • The appearance of the mass was highly suggestive of a lymphoproliferative disease, and biopsy confirmed the diagnosis of Hodgkin lymphoma (Appendix 1, available at www.cmaj.ca/lookup/suppl/doi:10.1503/cmaj.190910/-/DC1 ). (cmaj.ca)
  • Mediastinal lymphoma is a rare cause of Horner syndrome, but should be kept in the differential diagnosis because the respiratory symptoms may be absent or subtle. (cmaj.ca)
  • Diagnosis of lymphoma begins with a history and physical exam. (innerbody.com)
  • A booklet explaining non-Hodgkin lymphoma, covering the causes and symptoms, diagnosis, staging and grading, treatments and clinical trials. (macmillan.org.uk)
  • [2] [3] Diagnosis is by finding Hodgkin cells such as multinucleated Reed-Sternberg cells (RS cells) in lymph nodes. (wikipedia.org)
  • Currently, in most institutions the identification of the different DLBCL subtypes at diagnosis is addressed through immunohistochemistry, which often relies on the skills of experienced hemato-pathologists with expertise in the field of lymphoma. (elsevier.com)
  • The most recent data suggest that about 71 percent of people of all races with non-Hodgkin lymphoma are still alive five years after diagnosis. (cbsnews.com)
  • Hodgkin lymphoma is a type of cancer that affects the lymphatic system . (kidshealth.org)
  • When lymphoma happens, cancer cells develop in a person's lymphatic system and start to grow uncontrollably. (kidshealth.org)
  • There are four stages of lymphoma, ranging from Stage I (cancer involving only one area of lymph nodes or only one organ outside the lymph nodes) to Stage IV (cancer has spread, or metastasized, to one or more tissues or organs outside the lymphatic system). (kidshealth.org)
  • See also Hodgkin disease , immune system , lymphatic system . (cancer.org)
  • Hodgkin lymphoma begins in the lymph nodes of the neck or chest and then spreads from one part of the lymphatic system to another. (kidshealth.org)
  • Also known as Hodgkin's disease (HD), Hodgkin lymphoma is a blood cancer that starts in the lymphatic system. (redorbit.com)
  • Hodgkin's lymphoma is a rare cancer of the lymphatic system that affects groups of lymph nodes, such as those found in the neck, armpits or groin. (news-medical.net)
  • However, in some cases, non-Hodgkin lymphoma first develops in an organ or somewhere else outside the lymphatic system (the network of lymph vessels and glands found throughout the body). (www.nhs.uk)
  • lymphoma, non-Hodgkin's, any cancer of the lymphoid tissue (see lymphatic system ) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present. (factmonster.com)
  • Hodgkin lymphoma is a type of cancer that affects the lymphatic system, including the lymph nodes. (medicalnewstoday.com)
  • Hodgkin lymphoma is a type of cancer that develops in the lymphatic system , which is a part of the immune system . (medicalnewstoday.com)
  • Hodgkin's lymphoma is a type of cancer in the lymphatic system. (merlot.org)
  • Hodgkin's lymphoma causes the cells in the lymphatic system to abnormally reproduce, eventually making the body less able to fight infection and cause swelling in the lymph nodes. (merlot.org)
  • Non-Hodgkin's lymphoma, also known as non-Hodgkin lymphoma or NHL, is a form of cancer that has an effect on the lymphatic system. (medic8.com)
  • Non-Hodgkin lymphoma is an uncommon cancer that develops in the lymphatic system. (nidirect.gov.uk)
  • Because lymphatic tissue is in many parts of the body, Hodgkin lymphoma can start almost anywhere. (smartdraw.com)
  • Hodgkin lymphoma causes abnormal growth of the cells in the lymphatic system. (nationwidechildrens.org)
  • Hodgkin lymphoma is a type of cancer called a lymphoma , which is a cancer of the lymphatic system. (rchsd.org)
  • non-Hodgkin lymphoma (NHL) is the main subtype of lymphoma that originated from the lymphatic hematopoietic system. (medscape.com)
  • Non-Hodgkin's lymphoma is a type of cancer of the lymph glands and other lymphatic tissue-a part of your body's immune system that helps to fight infection and illness. (va.gov)
  • Non- Hodgkin's lymphoma (NHL) is cancer that originates in the lymphatic system. (medicinenet.com)
  • Non-Hodgkin's lymphoma is a type of cancer that originates in the cells of the lymphatic and immune systems, such as the blood cells known as lymphocytes and the lymph node tissues. (medicinenet.com)
  • Another type of lymphatic cancer is Hodgkin's disease, which is a type of lymphoma (cancer of the lymph nodes ). (medicinenet.com)
  • Lymphoma is the name for a group of blood cancers that develop in the lymphatic system. (lls.org)
  • Hodgkin Lymphoma (HL) Is a cancer that affects the lymphatic system, which is part of the body's immune system Is one of the most curable forms of cancer Is named for Dr. Thomas Hodgkin who, in 1832, described several cases of people with symptoms of a cancer involving the lymph nodes. (lls.org)
  • Non-Hodgkin Lymphoma (NHL) Is a type of cancer that generally develops in the lymph nodes and lymphatic tissue found in organs such as the stomach, intestines or skin. (lls.org)
  • Eventually lymphoma cells crowd out healthy lymphocytes and form tumors in the organs of the lymphatic system. (innerbody.com)
  • Lymphoma is a general term for cancers that develop in the lymphatic system (the tissues and organs that produce, store and carry white blood cells). (mdanderson.org)
  • Hodgkin lymphoma is a type of cancer that originates in certain white blood cells (B cells) in the lymphatic system. (moffitt.org)
  • By traveling through the lymphatic system, lymphoma can spread among lymph nodes and also to other tissues and organs. (moffitt.org)
  • Researchers are still discovering new characteristics of Hodgkin lymphoma, a common form of cancer of the lymphatic system. (innovations-report.com)
  • In Hodgkin's lymphoma, cells in the lymphatic system grow abnormally and may spread beyond the lymphatic system. (ucsfhealth.org)
  • Hodgkin lymphoma, sometimes called Hodgkin disease, is a type of lymphoma - a general term for cancer of the lymphatic system (the various lymph glands around the body). (cancer.org.au)
  • Non-Hodgkin lymphoma, or non-Hodgkin disease, is a cancer of the lymphatic system. (drugs.com)
  • A large group of lymphomas (cancers of the lymphatic system). (nih.gov)
  • Common signs and symptoms of Hodgkin lymphoma One of the two major types of lymphoma that begin in the lymph nodes and tissues of the lymphatic system. (lymphoma.org)
  • Children with this type of non-Hodgkin lymphoma usually have lymphatic system involvement, as well as a non-lymph structure (such as lung, jaw, skin, and bone) involvement. (childrensnational.org)
  • Non-Hodgkin lymphoma (NHL) is cancer that affects the lymphatic system, a part of the body's immune system. (medicinenet.com)
  • Hodgkin lymphoma may be treated with chemotherapy , radiation therapy , and stem cell transplant . (wikipedia.org)
  • Abbreviated 8-week chemotherapy (CT) plus involved node radiotherapy (INRT) for nonbulky stage I-II Hodgkin lymphoma: preliminary results of the Stanford G5 Study. (springer.com)
  • Involved field radiotherapy for patients in partial remission after chemotherapy for advanced Hodgkin's lymphoma. (springer.com)
  • Recent interim analysis of the HD11 trial of the GHSG: intensification of chemotherapy and reduction of radiation dose in early unfavorable stage Hodgkin's lymphoma. (springer.com)
  • Ten-year results of a German Hodgkin Study Group randomized trial of standard and increased dose BEACOPP chemotherapy for advanced Hodgkin lymphoma (HD9). (springer.com)
  • Dose escalation of BEACOPP chemotherapy for advanced Hodgkin's disease in the HD9 trial of the German Hodgkin's Lymphoma Study Group (GHSG). (springer.com)
  • a doctor who treats lymphoma with chemotherapy, immunotherapy, and targeted therapy. (cancer.org)
  • High-dose chemotherapy may be given when Hodgkin lymphoma returns after treatment or does not respond to the first treatment. (medlineplus.gov)
  • Treatment options for non-Hodgkin's lymphoma include new mixes of medicine ( chemotherapy and targeted therapy ), stem cell transplants , surgery, radiation therapy and new approaches offered in research studies. (seattlechildrens.org)
  • Low-grade lymphoma is regularly treated with chemotherapy, while high-grade lymphoma is treated with a combination of chemotherapy and steroids. (medic8.com)
  • In June 2007, a 48-year-old male patient, diagnosed with Stage 4 Non-Hodgkin's Follicular Lymphoma (NHL), was treated for 3 months with conventional chemotherapy resulting in a complete remission. (hindawi.com)
  • Treatment for Hodgkin's lymphoma depends on the stage of the lymphoma and may include radiation or chemotherapy. (healthlinkbc.ca)
  • With the support of her mother, a 17-year-old Connecticut patient battles child services, which is forcing her to undergo unwanted chemotherapy treatments for Hodgkin's lymphoma. (medicaldaily.com)
  • The most common treatment for Hodgkin's lymphoma is chemotherapy (drugs). (webmd.com)
  • Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. (nih.gov)
  • U.S. regulators on Tuesday approved Seattle Genetics Inc.'s Adcetris as part of a chemotherapy cocktail to treat advanced Hodgkin's lymphoma in newly diagnosed patients, making it the first new treatment in over 40 years. (newsmax.com)
  • The drug already has approval in the U.S. to treat other forms of blood cancer as well as patients with Hodgkin's lymphoma who have already received a stem cell transplant or two chemotherapy treatments. (newsmax.com)
  • U.S. regulators approved Seattle Genetics Inc.'s Adcetris as part of a chemotherapy cocktail to treat advanced Hodgkin's lymphoma in newly diagnosed patients. (newsmax.com)
  • Hodgkin lymphoma patients who fail to achieve complete remission following frontline therapy or who relapse after achieving complete remission are often treated with second-line chemotherapy regimens, followed by a bone marrow or stem cell transplant. (lymphoma.org)
  • Most patients with Hodgkin's lymphoma receive chemotherapy, radiation therapy or a combination of both. (ucsfhealth.org)
  • A combination of radiotherapy and chemotherapy is often used to treat early stage Hodgkin lymphoma. (cancer.org.au)
  • In advanced Hodgkin lymphoma, chemotherapy is the principal treatment. (cancer.org.au)
  • it combines an anti-CD30 monoclonal antibody with a chemotherapy drug to directly target classical Hodgkin lymphoma cells, which express CD30 on their surfaces (Figure 3). (healio.com)
  • The drug was approved in 2011 for the treatment of patients with classical Hodgkin lymphoma who have failed high-dose chemotherapy with autologous stem cell rescue (HDT/ASCR) or have failed at least two prior chemotherapy regimens. (healio.com)
  • If you are newly diagnosed with Hodgkin lymphoma, your doctor may recommend chemotherapy alone or a combination of radiation and chemotherapy. (mskcc.org)
  • With chemotherapy, drugs are taken intravenously (IV) or in pill form to kill rapidly dividing lymphoma cells throughout your body. (mskcc.org)
  • One of the most common and highly effective chemotherapy regimens used for Hodgkin lymphoma is called ABVD. (mskcc.org)
  • We are studying whether novel drugs can be safely and effectively combined with chemotherapy, radiotherapy, and stem cell transplantation to increase the cure rate for newly diagnosed, relapsed, and refractory Hodgkin lymphoma patients. (mskcc.org)
  • Non-Hodgkin lymphoma has also been linked to chemotherapy and radiation therapy. (childrensnational.org)
  • What Are the Signs & Symptoms of Hodgkin Lymphoma? (kidshealth.org)
  • The symptoms of Hodgkin lymphoma can be like other health conditions. (nationwidechildrens.org)
  • The signs and symptoms of Hodgkin lymphoma vary from person to person. (rchsd.org)
  • In fact, all of the symptoms of Hodgkin lymphoma can also be caused by other conditions, which is why only a doctor can determine what's really wrong. (rchsd.org)
  • Symptoms of Hodgkin lymphoma include swollen lymph nodes, a fever, weight loss, and night sweats. (rexhealth.com)
  • In Hodgkin lymphoma, the tumors usually contain unique cells called Reed-Sternberg cells. (kidshealth.org)
  • The genome of the Epstein-Barr virus is present in 20 to 80 percent of Hodgkin lymphoma tumors. (redorbit.com)
  • BRIEF SUMMARY: This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with solid solid tumors or lymphoma that are recurrent or refractory to standard therapy. (cincinnatichildrens.org)
  • Surgery is rarely used to treat Hodgkin lymphoma, considering that lymphomas do not often produce solid tumors in the way that many other cancers do. (moffitt.org)
  • Nanovector is currently preparing a final test phase for its Betalutin drug candidate, a treatment for Non-Hodgkin Lymphoma (NHL) designed to attach itself to tumors in a novel way before killing them with a dose of radiation. (reuters.com)
  • In a report in The Journal of Molecular Diagnostics , researchers describe their development of a reliable, accessible, rapid, and cost-effective new gene expression signature assay that can enhance lymphoma management by helping to match tumors with the appropriate targeted therapy. (elsevier.com)
  • Non-Hodgkin lymphoma causes lymphocytes to grow and divide without control and to form tumors. (drugs.com)
  • [2] [3] There are two major types of Hodgkin lymphoma: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma . (wikipedia.org)
  • Histopathological features of classical Hodgkin lymphoma (cHL). (hindawi.com)
  • This topic is about the most common type of Hodgkin lymphoma, called classical Hodgkin lymphoma. (rexhealth.com)
  • classical Hodgkin lymphoma accounts for approximately 95% of the cases in the United States, while nodular lymphocyte predominant Hodgkin lymphoma represents the remaining cases. (healio.com)
  • The immunotherapeutic agents discussed in this section are approved for the treatment of classical Hodgkin lymphoma only. (healio.com)
  • In 2016, the anti-PD-1 checkpoint inhibitor nivolumab was approved for the treatment of classical Hodgkin lymphoma in patients who have relapsed or progressed following HDT/ASCR and treatment with brentuximab vedotin. (healio.com)
  • On March 14, the Food and Drug Administration (FDA) approved pembrolizumab (Keytruda®) for the treatment of some patients with classical Hodgkin lymphoma (cHL). (cancer.gov)
  • The Society's mission is to cure leukemia, lymphoma, Hodgkin's disease, and myeloma, and to improve the quality of life of patients and their families. (kidshealth.org)
  • However, there is a very slightly increased risk of Hodgkin lymphoma if other family members have had the disease. (kidshealth.org)
  • The Center for Disease Control and Prevention (CDC) included certain types of non-Hodgkin's lymphoma as AIDS-defining cancers in 1987. (wikipedia.org)
  • The difference between non-Hodgkin lymphoma and Hodgkin disease is the Reed-Sternberg cell , which is absent in non-Hodgkin lymphoma cells. (cancer.org)
  • When Hodgkin disease is suspected, doctors will order a number of tests. (kidshealth.org)
  • More specifically, children who have a parent with Hodgkin lymphoma are more likely develop the disease. (redorbit.com)
  • Hodgkin disease is a type of lymphoma. (medlineplus.gov)
  • The first sign of Hodgkin disease is often an enlarged lymph node. (medlineplus.gov)
  • Hodgkin disease is rare. (medlineplus.gov)
  • To diagnose Hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. (medlineplus.gov)
  • In most cases, Hodgkin disease can be cured. (medlineplus.gov)
  • How Is Hodgkin Disease Diagnosed? (medlineplus.gov)
  • What Are the Risk Factors for Hodgkin Disease? (medlineplus.gov)
  • What Happens After Treatment for Hodgkin Disease? (medlineplus.gov)
  • What Are the Key Statistics for Hodgkin Disease? (medlineplus.gov)
  • What's New in Hodgkin Disease Research and Treatment? (medlineplus.gov)
  • Accordingly, the disease has been included among malignant lymphomas, and the term "Hodgkin's lymphoma" has been proposed [ 10 - 12 ]. (hindawi.com)
  • In lymphoma, bulky disease may mean a person requires more treatment. (medicalnewstoday.com)
  • Are you going through treatment for non-Hodgkin Lymphoma or another disease that may require a stem-cell transplant? (caringbridge.org)
  • Hodgkin's disease is distinguished from other types of lymphomas by the presence of a particular type of diseased cell, called the Reed-Sternberg cell. (merlot.org)
  • In most cases the cause of non-Hodgkin's lymphoma is unknown and some people who are diagnosed with the disease could have no risk factors. (medic8.com)
  • This book, now in its third edition, examines the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the appropriate management in special clinical circumstances, including in the elderly, pregnant women, and those with nodular lymphocyte-predominant disease (NLPHL). (springer.com)
  • 8 in 10 (80%) people diagnosed with Hodgkin lymphoma in England and Wales survive their disease for ten years or more (2010-11). (cancerresearchuk.org)
  • Around 9 in 10 (91%) people diagnosed with Hodgkin lymphoma in England and Wales survive their disease for one year or more (2010-11). (cancerresearchuk.org)
  • 95% of people in England diagnosed with Hodgkin lymphoma aged 15-39 survive their disease for five years or more, compared with more than a quarter of people diagnosed aged 80 and over (2009-2013). (cancerresearchuk.org)
  • In the 1970s, almost half of people diagnosed with Hodgkin lymphoma survived their disease beyond ten years, now it's 8 in 10. (cancerresearchuk.org)
  • Treatment for Hodgkin's lymphoma depends on what type you have and the stage of the disease. (healthlinkbc.ca)
  • Swerdlow, A.J. (2003) Epidemiology of hodgkin's disease and non-Hodgkin's lymphoma. (scirp.org)
  • But when the medicine did not decrease the swelling, the doctor recommended some tests, telling Justin and his mother that they were necessary to check for disease, including lymphoma. (rchsd.org)
  • People who have a close relative who has had Hodgkin lymphoma seem to be slightly more likely to get the disease, as are people who have had an organ transplant or who have acquired immunodeficiency syndrome (AIDS). (rchsd.org)
  • Both Hodgkin's disease (sometimes referred to as Hodgkin's lymphoma) and non-Hodgkin's lymphoma are cancers that originate in a type of white blood cell known as a lymphocyte, an important component of the body's immune system. (medicinenet.com)
  • The distinction between Hodgkin's disease and non-Hodgkin's lymphoma is made upon examination of the cancerous material (from a biopsy or aspiration of the tumor tissue). (medicinenet.com)
  • The type of abnormal cells identified in the sample determines whether a lymphoma is classified as Hodgkin's disease or non-Hodgkin's lymphoma. (medicinenet.com)
  • What is the difference between non-Hodgkin's lymphoma and Hodgkin's disease (or Hodgkin's lymphoma)? (medicinenet.com)
  • Distinguishing the type of lymphoma is important because treatment, disease course, and prognosis can be quite different. (medicinenet.com)
  • The disease was called "Hodgkin's disease" until it was officially renamed "Hodgkin lymphoma" in the late 20th ce. (lls.org)
  • The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
  • In 2014, about 9,000 people will be diagnosed with Hodgkin lymphoma, and 1,000 will die from the disease. (innerbody.com)
  • Some types of Hodgkin lymphoma are more common in people whose relatives also have the disease. (innerbody.com)
  • At MD Anderson's Lymphoma and Myeloma Center, our goal is to treat non-Hodgkin's lymphoma with methods that are strong on the disease, but as gentle as possible on your body. (mdanderson.org)
  • While some patients with non-Hodgkin's lymphoma can be successfully treated, for many the most effective course is to keep knocking back the disease over a period of many years. (mdanderson.org)
  • Hodgkin's disease is a type of lymphoma that develops in white blood cells. (mdanderson.org)
  • It was not until 1994, some 160 years after Hodgkin's lymphoma (HL) was first described by the British physician Thomas Hodgkin (1832), that - using molecular biological methods - scientists discovered that the disease originates from the white blood cells, the B cells. (innovations-report.com)
  • Hodgkin lymphoma, also called Hodgkin disease, is a cancer of a part of the immune system called the lymph system, which is made up of lymph tissue. (bidmc.org)
  • Treatment for Hodgkin lymphoma will depend on how advanced the disease is as well as your age, symptoms and overall health. (cancer.org.au)
  • It has the capability to simultaneously evaluate the expression of 21 markers, allowing differentiation of the three subtypes of DLBCLs (GCB, ABC, and primary mediastinal B-cell lymphoma, PMBL) as well as other individualized disease characteristics, such as Epstein Barr infection status. (elsevier.com)
  • Hematologic oncologists like David Straus help develop a personalized treatment plan for Hodgkin lymphoma that takes into account the type and stage of the disease. (mskcc.org)
  • The Lymphoma Research Foundation's mission is to eradicate lymphoma and serve those touched by this disease. (lymphoma.org)
  • Staging and classification of non-Hodgkin lymphoma is based on the extent of the disease and the specific cells involved. (childrensnational.org)
  • Children and adults with certain hereditary immune system abnormalities have an increased risk of developing non-Hodgkin lymphoma, including patients with ataxia telangiectasia, X-linked lymphoproliferative disease, or Wiskott-Aldrich syndrome. (childrensnational.org)
  • Nephrotic syndrome can occur in individuals with Hodgkin lymphoma and is most commonly caused by minimal change disease. (wikipedia.org)
  • B cell lymphoma is not one disease but a few dozen heterogeneous diseases, or individual cancers, that affect the b. (lymphomainfo.net)
  • Also known as Hodgkin's disease , Hodgkin's lymphoma (HL) is a cancer of the white blood cells, or. (lymphomainfo.net)
  • Patients with either relapsed or refractory non-Hodgkin lymphoma or chronic lymphocytic leukemia treated with CAR NK cells had a response without the development of cytokine release syndrome, neurotoxicity, or graft-versus-host disease. (medworm.com)
  • Keep clicking to learn more about non-Hodgkin lymphoma and other famous people who battled the disease. (cbsnews.com)
  • Former first lady Jackie Kennedy was diagnosed with non-Hodgkin lymphoma in early 1994 and died of the disease a few months later. (cbsnews.com)
  • Just a few decades ago, non-Hodgkin lymphoma was a relatively rare disease. (cbsnews.com)
  • Each year, about 74,600 new cases of non-Hodgkin lymphoma are diagnosed, and about 19,900 people will die from the disease, according to 2018 estimates from the American Cancer Society. (cbsnews.com)
  • the surgical management of Hodgkin's Disease and non-Hodgkin's lymphomas. (upenn.edu)
  • Non-Hodgkin lymphoma ( NHL ) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas . (wikipedia.org)
  • Hodgkin lymphoma is one of the most curable cancers. (medlineplus.gov)
  • Unlike other cancers, Hodgkin lymphoma is also very curable in its late stages. (medlineplus.gov)
  • Non-Hodgkin's lymphoma is a group of cancers that start in lymphocytes -- your immune system's infection-fighting white blood cells . (webmd.com)
  • Peripheral T-cell lymphomas are a group of aggressive cancers that start in T cells. (webmd.com)
  • Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the Investigational New Drug (IND) application for Calibr's "switchable" CAR-T cell therapy, which is being evaluated for the treatment of certain cancers, including relapsed/refractory B-cell malignancies such as non-Hodgkin lymphoma and chronic lymphocytic leukemia. (news-medical.net)
  • Hodgkin lymphoma is not among the 20 most common cancers in the UK, accounting for less than 1% of all new cancer cases (2016). (cancerresearchuk.org)
  • In females in the UK, hodgkin lymphoma is not among the 20 most common cancers, with around 880 new cases in 2016. (cancerresearchuk.org)
  • Like other cancers, Hodgkin lymphoma can spread (metastasize) to other parts of the body. (rexhealth.com)
  • Hodgkin lymphoma is a very curable cancer compared to other cancers. (rexhealth.com)
  • Both of these cancers are lymphomas, a cancer that begins in lymphocytes. (medicinenet.com)
  • Hodgkin lymphoma accounts for less than 1% of all cancers in the UK (2014). (cancerresearchuk.org)
  • Non-Hodgkin lymphoma is one of the most common cancers in the United States, accounting for about four percent of all cancers. (innerbody.com)
  • All cancers, including lymphoma, begin when a cell's genetic information is damaged. (innerbody.com)
  • We are dedicated to discovering better treatments for lymphoma and other cancers through research. (ucsfhealth.org)
  • Hodgkin lymphoma is a rare cancer accounting for approximately 0.5% of all cancers diagnosed in Australia. (cancer.org.au)
  • The Hematologic Malignancies Program conducts research related to non-Hodgkin's lymphoma and other blood and bone marrow cancers. (mayoclinic.org)
  • Certain types of NHLs, such as Burkitt lymphoma and immunoblastic lymphoma, are AIDS-defining cancers in people with HIV. (nih.gov)
  • Non-Hodgkin may be a second malignancy as a result of the treatment for certain cancers. (childrensnational.org)
  • Approximately 8,000 cases (4,400 males and 3,820 females) of Hodgkin's Lymphoma are detected per year which represents less than 1% of all cancers. (lymphomainfo.net)
  • There are some cancers such as mantle cell lymphoma, which do not fall into either category. (medicinenet.com)
  • Like most cancers, the exact cause of Non-Hodgkin's lymphoma is unknown. (medicinenet.com)
  • Hodgkin's lymphoma ( HL ) is a type of lymphoma in which cancer originates from a specific type of white blood cells called lymphocytes . (wikipedia.org)
  • Lymphomas are types of cancer that develop from lymphocytes , a type of white blood cell . (wikipedia.org)
  • Hodgkin lymphoma usually begins in B lymphocytes, a type of white blood cells that produce antibodies to help the immune system mount a response to infection . (medicalnewstoday.com)
  • In non-Hodgkin lymphoma, the affected lymphocytes start to multiply in an abnormal way. (nidirect.gov.uk)
  • Hodgkin's lymphoma is cancer that begins in the lymph system in white blood cells called lymphocytes. (healthlinkbc.ca)
  • Lymphoma is a form of cancer that affects the infection-fighting cells of the immune system called lymphocytes. (medicaldaily.com)
  • Non-Hodgkin lymphoma is a cancer that starts in immune-boosting white blood cells called lymphocytes. (upi.com)
  • Epidemiology: Non-Hodgkin's lymphomas (NHLs) arise from the malignant, monoclonal transformation of lymphocytes. (cmaj.ca)
  • Non-Hodgkin lymphoma (NHL) is a collection of about 50 subtypes of lymphoma that grow at different rates and affect different kinds of lymphocytes. (innerbody.com)
  • Lymphoblastic non-Hodgkin lymphoma accounts for about 30 percent of the cases, usually involves the T-cells (T-lymphocytes), and typically presents with a mass in the chest, swollen lymph node(s), with or without bone marrow and central nervous system involvement. (childrensnational.org)
  • In T cell lymphoma, T lymphocytes, which are an essential part of the body's immune response, become malignant. (lymphomainfo.net)
  • Lymphoma is a cancer affecting the white blood cells (lymphocytes) of the body's immune system. (lymphomainfo.net)
  • Non-Hodgkin's lymphoma involves the abnormal production of white blood cells (lymphocytes) affecting the immune system. (medicinenet.com)
  • PURPOSE: This is a 2-part study of pembrolizumab (MK-3475) in pediatric participants who have either advanced melanoma or a programmed cell death ligand 1 (PD-L1)-positive advanced, relapsed or refractory solid tumor or lymphoma. (cincinnatichildrens.org)
  • The term "refractory" is used to describe when the lymphoma does not respond to treatment (meaning that the cancer cells continue to grow) or when the response to treatment does not last very long. (lymphoma.org)
  • To learn about treatments under investigation for HL, download the Hodgkin Lymphoma Booklet or Relapsed/ Refractory Hodgkin Lymphoma Fact Sheet . (lymphoma.org)
  • Phase 1/2 trials are underway evaluating nivolumab for the treatment of previously treated or newly diagnosed Hodgkin lymphoma, and nivolumab in combination with brentuximab vedotin for the treatment of older patients with previously untreated Hodgkin lymphoma and patients with relapsed or refractory Hodgkin lymphoma. (healio.com)
  • Both ipilimumab and pembrolizumab are being investigated in combination with brentuximab vedotin for the treatment of relapsed or refractory Hodgkin lymphoma. (healio.com)
  • If you have Hodgkin lymphoma that doesn't get better after the first treatment, it is called refractory. (mskcc.org)
  • There are a number of treatment options we may recommend for refractory lymphoma or lymphoma that has returned (relapsed). (mskcc.org)
  • Experts at MSK have led efforts to gain FDA approval of lifesaving and novel treatment approaches for relapsed and refractory Hodgkin lymphoma. (mskcc.org)
  • University of Texas M. D. Anderson Cancer Center) According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), with no major toxicities observed. (medworm.com)
  • A few people with lymphoma have abnormal cells in their bone marrow when they're diagnosed. (www.nhs.uk)
  • Intensive lymphoma treatment affects the bone marrow, causing anemia , easy bleeding, and increasing the risk for serious infections. (kidshealth.org)
  • Some patients have abnormal cells in their bone marrow at the time they are diagnosed with Hodgkin's lymphoma. (news-medical.net)
  • Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
  • Non-Hodgkin lymphoma also can develop in your bone marrow and blood. (familydoctor.org)
  • I had to eventually get a bone marrow biopsy, and that was when I realized I had stage 4 Hodgkin lymphoma, as the cancer had spread to my bone marrow. (healthline.com)
  • Patients with aggressive non Hodgkin's lymphoma don't necessarily benefit from bone marrow transplant (BMT), a new study shows. (healthy.net)
  • Hodgkin lymphoma can spread to nearby lymph nodes, and later may spread to the lungs, liver, or bone marrow. (bidmc.org)
  • The lymphoma is in the chest or spine, or it has spread widely in the abdomen, or it is both above and below the diaphragm, but it does not involve bone marrow or the central nervous system. (childrensnational.org)
  • Any lymphoma that has bone marrow and/or central nervous system involvement when it is first found. (childrensnational.org)
  • Bone trauma and microfractures associated with diffuse large B-cell lymphoma originating in bone marrow. (wikipedia.org)
  • Revised response criteria for malignant lymphoma. (medscape.com)
  • Since then, his group focused on developing antibody-based immunotherapy for patients with malignant lymphoma leading to a number of phase I/II clinical trials. (springer.com)
  • Malignant lymphomas and chronic lymphocytic leukaemia. (cmaj.ca)
  • If you have further questions about Hodgkin lymphoma, you are welcome to reach out to the multispecialty team in the Malignant Hematology Program at Moffitt Cancer Center. (moffitt.org)
  • They noticed, however, that the malignant Hodgkin/Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) exhibit a phenotype and characteristics that are considerably altered. (innovations-report.com)
  • Hodgkin lymphoma differs from non-Hodgkin lymphoma in that Hodgkin lymphoma shows the presence of Reed-Sternberg cells - mature B cells (a type of white blood cell) that are unusually large and malignant. (bidmc.org)
  • Non-Hodgkin lymphoma (NHL) consists of a diverse group of malignant neoplasms variously derived from B cell progenitors, T cell progenitors, mature B cells, mature T cells, or (rarely) natural killer cells. (uptodate.com)
  • Complete response as assessed by CT and PET scans and revised response criteria for malignant lymphoma. (clinicaltrials.gov)
  • The different subtypes of Hodgkin lymphoma are classified based on how the cancerous tissue looks under a microscope. (kidshealth.org)
  • But first, it is important to examine the main subtypes of Hodgkin lymphoma. (redorbit.com)
  • There are several different subtypes of Hodgkin lymphoma, based on how the cancerous tissue looks under a microscope. (rchsd.org)
  • The Leukemia & Lymphoma Society is dedicated to funding blood-cancer research, education, and patient services. (kidshealth.org)
  • The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against cancer. (lls.org)
  • The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (lls.org)
  • In 2014, there were about 584,000 people in the United States living with non-Hodgkin lymphoma, according to the Leukemia & Lymphoma Society. (everydayhealth.com)
  • Addition of rituximab to BEACOPP escalated to improve the outcome of early interim PET positive advanced stage Hodgkin lymphoma patients: second planned interim analysis of the HD18 study. (springer.com)
  • Eight cycles of BEACOPP escalated compared with 4 cycles of BEACOPP baseline with or without radiotherapy in patients in advanced stage Hodgkin lymphoma (HL): final analysis of the HD12 trial of the Germa Hodgkin Study Group (GHSG). (springer.com)
  • There are several factors and tests to correctly diagnose Hodgkin lymphoma. (redorbit.com)
  • A lymph node biopsy is needed to diagnose Hodgkin lymphoma. (nationwidechildrens.org)
  • This is the most common test to diagnose Hodgkin lymphoma. (cancer.org.au)
  • Understanding Hodgkin Lymphoma, Cancer Council NSW © 2017. (cancer.org.au)
  • The first sign of Hodgkin lymphoma is often a swollen lymph node that appears without a known cause. (medlineplus.gov)
  • The most common symptom of Hodgkin lymphoma is a swollen lymph node under the skin. (medicalnewstoday.com)
  • My doctor told me it could be Hodgkin lymphoma and sent me to see a specialist to undergo a lymph node biopsy. (healthline.com)
  • The most common symptom of non-Hodgkin lymphoma is a painless swelling in a lymph node. (nidirect.gov.uk)
  • The most common symptom of lymphoma is an enlarged lymph node, which usually appears in the neck, groin, armpit or above the collarbone . (innerbody.com)
  • If lymphoma is suspected, the doctor will order a biopsy (surgical removal) of lymph node tissue. (innerbody.com)
  • Hodgkin lymphoma must be distinguished from non-cancerous causes of lymph node swelling (such as various infections) and from other types of cancer. (wikipedia.org)
  • Nodular sclerosis Hodgkin lymphoma (NSCHL): the most common type of Hodgkin lymphoma in developed countries found in 7 out of 10 cases. (redorbit.com)
  • The several subtypes of Hodgkin's lymphoma are nodular sclerosing, lymphocyte depleted, lymphocyte predominant, and mixed cellularity. (merlot.org)
  • Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of Hodgkin lymphoma (HL). (uptodate.com)
  • [5] It was named after the English physician Thomas Hodgkin , who first described the condition in 1832. (wikipedia.org)
  • Treatments for Hodgkin lymphoma can have complications. (medlineplus.gov)
  • After chemo treatments, the non-Hodgkin Lymphoma returned. (caringbridge.org)
  • MD Anderson has helped advance the treatment of non-Hodgkin's lymphoma in many areas, including development of new, leading-edge treatments. (mdanderson.org)
  • It may also be offered when the lymphoma has not responded well to other treatments. (cancer.org.au)
  • Mayo applies that research to developing more effective and less toxic treatments for all forms of lymphoma. (mayoclinic.org)
  • He received a number of awards including the Ludwig-Heilmeyer-Medal, the DGHO Arthur-Pappenheim Prize, the Research Award of the University of Cologne, the award of the German Cancer Society 2011, the Paul-Martini-Prize 2013 and the John Ultmann Lymphoma Award 2017 and others. (springer.com)
  • Hodgkin lymphoma involves the presence of an abnormal cell called a Reed-Sternberg cell. (redorbit.com)
  • If you have non-Hodgkin lymphoma, your white blood cells become abnormal. (familydoctor.org)
  • Hodgkin lymphoma (also called Hodgkin's lymphoma) is characterized by the presence of large, abnormal cells. (innerbody.com)
  • Follicular lymphoma international prognostic index. (medscape.com)
  • A population-based cohort study in Taiwan showed that HBV infection was significantly associated with an increased risk of diffuse large B-cell lymphoma (DLBCL) but not with the risk of T-cell NHL and follicular lymphoma (FL). (medscape.com)
  • Examples of lymphomas that typically have indolent presentations include follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and splenic marginal zone lymphoma. (uptodate.com)
  • The most common type of lymphoma is follicular lymphoma. (medicinenet.com)
  • This book is intended for medical and healthcare professionals involved in the research and clinical care of patients with non-Hodgkin lymphoma. (springer.com)
  • Hodgkin's lymphoma (HL) is a lymphoid tumor representing less than 1% of all de novo neoplasms occurring every year world wide [ 1 ]. (hindawi.com)
  • Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging. (medscape.com)
  • [ 12 ] However, it is not known whether scores developed in ambulatory solid tumor patients can be used in lymphoma patients in general and in HL patients in particular. (medscape.com)
  • Björn Lamprecht and Dr. Stephan Mathas (Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch and Charité - Universitätsmedizin Berlin, Germany) have demonstrated the production of interleukin 21 (IL-21) in the tumor cells of Hodgkin lymphoma. (innovations-report.com)
  • The production of such chemoattractants could, according to the researchers, also be a cause for why Hodgkin lymphoma contains so few tumor cells. (innovations-report.com)
  • If we could block IL-21 or also MIP-3 alpha in human tumor cells," Dr. Mathas added, "this might be a new therapeutic approach for Hodgkin lymphoma. (innovations-report.com)
  • It binds to a protein found on the surface of Hodgkin lymphoma tumor cells and kills the cells. (mskcc.org)
  • Humboldt Ashlyn Clark was diagnosed with Hodgkin's lymphoma in May. (desmoinesregister.com)
  • It's an unbelievable story': Humboldt softball player Ashlyn Clark inspiring others as she fights cancer Humboldt Ashlyn Clark was diagnosed with Hodgkin's lymphoma in May. (desmoinesregister.com)
  • Burkitt lymphoma grows from B-cells, one type of lymphocyte. (nationwidechildrens.org)
  • 95% CI: 1.11-2.12), but not with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) and Burkitt lymphoma. (medscape.com)
  • It makes grants to medical researchers at the Lymphoma Trials Office who organise clinical trials and operate a database containing details of over 19,600 patients. (cancerindex.org)
  • Based on proof-of-concept results from clinical trials at University of North Carolina Lineberger Comprehensive Cancer Center and Baylor College of Medicine, an investigational cellular immunotherapy for Hodgkin lymphoma has received a Regenerative Medicine Advanced Therapy designation from the U.S. Food and Drug Administration. (news-medical.net)
  • Dr Younes also conducts laboratory-based research aiming at translating the current knowledge into innovative clinical trials to improve the cure rate and survival of patients with Hodgkin and non-Hodgkin lymphoma. (springer.com)
  • To learn more about available lymphoma clinical trials, contact us at [email protected] or 513-636-2799. (cincinnatichildrens.org)
  • This means we are able to offer a wide range of clinical trials (research studies) for every type and stage of non-Hodgkin's lymphoma. (mdanderson.org)
  • Our researchers are continually running clinical trials to improve treatment options for people with Hodgkin lymphoma. (mskcc.org)
  • There are around 2,100 new hodgkin lymphoma cases in the UK every year, that's nearly 6 every day (2014-2016). (cancerresearchuk.org)
  • In males in the UK, hodgkin lymphoma is the 19th most common cancer, with around 1,200 new cases in 2016. (cancerresearchuk.org)
  • There are around 330 hodgkin lymphoma deaths in the UK every year, that's around 1 every day (2014-2016). (cancerresearchuk.org)
  • Mortality rates for Hodgkin lymphoma in the UK are highest in people aged 80 to 84 (2014-2016). (cancerresearchuk.org)
  • In 2016, 82 people died from Hodgkin lymphoma in Australia. (cancer.org.au)
  • Diffuse B-cell lymphoma . (webmd.com)
  • Diffuse B-cell lymphoma mainly affects people in their 60s. (webmd.com)
  • Diffuse B-cell lymphoma has its own subtypes. (webmd.com)
  • Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer and the most frequently diagnosed non-Hodgkin lymphoma worldwide (nearly 40% of cases). (elsevier.com)
  • Burkitt's and non-Burkitt's lymphoma are fast-growing lymphomas in which the cells are undifferentiated and diffuse. (childrensnational.org)
  • Large cell or diffuse histiocytic non-Hodgkin lymphoma. (childrensnational.org)
  • Large cell or diffuse histiocytic non-Hodgkin involves the B-cells or T-cells and accounts for about 25 percent of the cases. (childrensnational.org)
  • The most common type is diffuse large B cell lymphoma. (medicinenet.com)
  • Also searched for Diffuse Small Cleaved-Cell Lymphoma . (clinicaltrials.gov)
  • Symptoms of Hodgkin's lymphoma include enlargement of the lymph nodes, fever, appetite loss, weight loss, and night sweats. (healthlinkbc.ca)
  • Aggressive lymphomas commonly present acutely or subacutely with a rapidly growing mass, systemic B symptoms (ie, fever, night sweats, weight loss), and/or elevated levels of serum lactate dehydrogenase and uric acid. (uptodate.com)
  • You can read more detailed information about the outlook for non-Hodgkin lymphoma on the Cancer Research UK website. (nidirect.gov.uk)
  • The most common first symptom of Hodgkin lymphoma is a painless enlargement of the lymph nodes (often called "swollen glands") in the neck, the underarm area, or the groin. (kidshealth.org)
  • However, it's highly unlikely that you have Hodgkin lymphoma if you have swollen lymph nodes , as these glands often swell as a response to infection. (www.nhs.uk)
  • Lymphoma is a cancer of a part of the immune system called the lymph system. (medlineplus.gov)
  • Non-Hodgkin lymphoma is cancer that begins in cells of the immune system. (smartdraw.com)
  • But just because you've had an organ transplant or have a compromised immune system doesn't mean you'll get Hodgkin lymphoma. (rchsd.org)
  • Nathan Fowler, M.D., is focusing his clinical research on finding new therapies that use the body's own immune system to fight non-Hodgkin's lymphoma. (mdanderson.org)
  • Researchers think that non-Hodgkin lymphoma may be associated with certain bacteria or viruses that weaken the immune system. (everydayhealth.com)
  • Non-Hodgkin lymphoma is rare in children, but those with congenital (present at birth) immune system problems may have a higher risk of developing NHL. (everydayhealth.com)
  • The non-Hodgkin's lymphoma that took Allen's life is a type of cancer that develops in the body's white blood cells and lymph nodes, which are part of the immune system. (usatoday.com)
  • Hodgkin lymphoma is a cancer of the immune system. (harvard.edu)
  • Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). (webmd.com)
  • If the biopsy confirms Hodgkin lymphoma, more tests might be done to see if the cancer has spread. (kidshealth.org)
  • To diagnose (or rule out) lymphoma, your doctor may order a biopsy. (familydoctor.org)
  • If the results of your biopsy indicate you have Hodgkin lymphoma you may have additional tests to determine how far the cancer has spread. (cancer.org.au)
  • Further tests after a biopsy will tell your doctor how far Hodgkin lymphoma has spread. (cancer.org.au)
  • Hodgkin lymphoma has characteristic cell, the Reed-Sternberg cell, seen by the pathologist under the microscope when looking at the tissue from the biopsy. (lymphoma.org)
  • Biopsy: A biopsy will be suggested if the size, texture, location, or presence of other symptoms strongly suggest a Non-Hodgkin's lymphoma. (medicinenet.com)
  • Indolent lymphomas grow slowly and may not need to be treated right away. (webmd.com)
  • Patients with indolent lymphomas may undergo watchful waiting at first, but eventually they will require treatment with an alkylating agent such as chlorambucil, with or without steroid therapy. (cmaj.ca)
  • Some types of non-Hodgkin lymphoma grow and spread slowly and are called indolent. (drugs.com)
  • Non-Hodgkin's lymphoma has two types: indolent lymphomas and aggressive lymphomas. (medicinenet.com)
  • The different types of lymphomas are grouped into two broad categories: Hodgkin lymphoma and non-Hodgkin lymphoma. (kidshealth.org)
  • [6] Within the four groups for NHL, there are over 60 specific types of lymphoma. (wikipedia.org)
  • Unfortunately, it is one of the more aggressive types of Hodgkin lymphoma. (redorbit.com)
  • There are about 10 different types of non-Hodgkin's lymphomas, some slower- or faster-growing than others. (factmonster.com)
  • The experts in our Leukemia and Lymphoma Program provide advanced therapies for children with all types of non-Hodgkin lymphoma, including lymphoma that recurs. (seattlechildrens.org)
  • There are two main types of lymphoma: Hodgkin's lymphoma and non-Hodgkin's lymphoma. (medic8.com)
  • There are many different types of non-Hodgkin's lymphoma and they are classed according to the type of cell they affected, categorising them as either B-cell or T-cell lymphomas. (medic8.com)
  • There are two types of non-Hodgkin lymphoma: B-cell and T-cell. (familydoctor.org)
  • Make people aware of the different types of Lymphoma I started this cause for anyone who has a relative or friend suffering from Non-Hodgkin's Lymphoma. (causes.com)
  • There are other types of Hodgkin lymphoma. (rexhealth.com)
  • WEDNESDAY, Aug. 8, 2018 -- Poteligeo (mogamulizumab) injection has been approved by the U.S. Food and Drug Administration to treat adults with two types of non-Hodgkin lymphoma. (upi.com)
  • Mycosis fungoides and Sézary syndrome are rare, hard-to-treat types of non-Hodgkin lymphoma and this approval fills an unmet medical need for these patients," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in an agency news release. (upi.com)
  • For Hodgkin lymphoma, like most cancer types, differences between countries largely reflect risk factor prevalence in years past. (cancerresearchuk.org)
  • For Hodgkin lymphoma, like most cancer types, incidence increases with age. (cancerresearchuk.org)
  • The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). (lls.org)
  • There many types of NHL, all of which are divided into two major groups: B cell lymphoma and T cell lymphoma. (mskcc.org)
  • There are also several types of relatively rare T cell non-Hodgkin lymphoma. (mskcc.org)
  • The many types of non-Hodgkin lymphoma (NHL) are classified according to how fast the cancer spreads. (nih.gov)
  • What are the different types of non-Hodgkin lymphoma? (childrensnational.org)
  • There are more than 80 types of non-Hodgkin lymphoma, according to the Lymphoma Research Foundation . (cbsnews.com)
  • Within the four groups for NHL are over 60 specific types of lymphoma. (wikipedia.org)
  • The Reed-Sternberg cell is not present in other forms of lymphoma, which are referred to as non-Hodgkin's lymphoma. (news-medical.net)
  • It is only possible to tell the difference between the two forms of lymphoma by examining the cancerous cells under a microscope. (medic8.com)
  • Mixed cellularity Hodgkin lymphoma (MCCHL): the second most common type of Hodgkin lymphoma, and is found in 4 out of 10 cases in developed countries. (redorbit.com)
  • Lymphocyte-rich Hodgkin lymphoma: the least common type of Hodgkin lymphoma. (redorbit.com)
  • But treatment success depends on your gender, the type of Hodgkin lymphoma you have, its stage, and your age when you are diagnosed. (rexhealth.com)
  • The specific Hodgkin lymphoma treatment you receive will depend on the sub-type of Hodgkin lymphoma you have, how far it has progressed when your Hodgkin lymphoma treatment starts, how the lymphoma responds to initial treatment, and other factors. (bidmc.org)
  • On the other hand, its positive predictive value is high enough for it to be regarded as a pathognomonic sign of Hodgkin lymphoma. (wikipedia.org)
  • The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin. (www.nhs.uk)
  • The swelling of the lymph nodes is the most common symptom of Hodgkin lymphoma. (redorbit.com)
  • The prognosis of Hodgkin lymphoma (HL) is excellent rendering research into treatment complications highly important. (medscape.com)
  • The prognosis of Hodgkin lymphoma (HL) is excellent and most patients can be cured with stage and risk factor adapted first line treatment [ 1 , 2 ] rendering treatment complications with potential long-term effects highly relevant for this group of patients. (medscape.com)
  • What Are the Side Effects of Treatment of Hodgkin Lymphoma? (kidshealth.org)
  • Infection with HIV can increase a person's risk of Hodgkin lymphoma. (medicalnewstoday.com)
  • A. Lymphoma is a cancer of the lymph system, a collection of ducts, nodes, and organs that transports lymph and helps protect the body against infection. (bhg.com)
  • Hodgkin lymphoma tends to occur more often in teens and in people with severe immune deficiencies from things such as inherited immune defects, human immunodeficiency virus (HIV) infection, or treatment with immunosuppressive drugs after organ transplants. (rchsd.org)
  • Previous studies have focused on the relationship between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL). (medscape.com)
  • [ 5 ] Studies on the aetiology of lymphoma have indicated that virus infection is the primary risk factor for NHL. (medscape.com)
  • These new "lymphoma" cells are flawed like the parent cell and don't help the body fight infection. (innerbody.com)
  • There are no proven measures to prevent lymphoma, however, people with an HIV infection or Epstein-Barr virus have an increased risk of contracting lymphoma. (cancer.org.au)
  • Unlike people with non-Hodgkin lymphoma, those with Hodgkin lymphoma have Reed-Sternberg cells . (medicalnewstoday.com)
  • Some people with non-Hodgkin lymphoma also have other more general symptoms. (nidirect.gov.uk)
  • More than 11,800 cases of non-Hodgkin's lymphoma are diagnosed every year in the UK. (medic8.com)
  • According to the American Cancer Society, about 66,000 new cases of non-Hodgkin's lymphoma are diagnosed each year in the United States. (mdanderson.org)
  • Lymphoma usually (but not always) begins in the lymph nodes. (innerbody.com)