Fumarates: Compounds based on fumaric acid.MaleatesATP Citrate (pro-S)-Lyase: An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.Polysaccharide-Lyases: A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.Adenylosuccinate Lyase: An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.Oxo-Acid-Lyases: Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.Argininosuccinate Lyase: An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC ACIDURIA in man. EC 4.3.2.1.Comamonadaceae: A family of gram-negative aerobic bacteria in the class BETA PROTEOBACTERIA, encompassing the acidovorans rRNA complex. Some species are pathogenic for PLANTS.Argininosuccinate Synthase: An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.Comamonas: A genus of gram-negative, straight or slightly curved rods which are motile by polar flagella and which accumulate poly-beta-hydroxybutyrate within the cells.Argininosuccinic Aciduria: Rare autosomal recessive disorder of the urea cycle which leads to the accumulation of argininosuccinic acid in body fluids and severe HYPERAMMONEMIA. Clinical features of the neonatal onset of the disorder include poor feeding, vomiting, lethargy, seizures, tachypnea, coma, and death. Later onset results in milder set of clinical features including vomiting, failure to thrive, irritability, behavioral problems, or psychomotor retardation. Mutations in the ARGININOSUCCINATE LYASE gene cause the disorder.Argininosuccinic Acid: This amino acid is formed during the urea cycle from citrulline, aspartate and ATP. This reaction is catalyzed by argininosuccinic acid synthetase.Lyases: A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.Rhizobium: A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.Agrobacterium tumefaciens: A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.Rhizobiaceae: A family of gram-negative bacteria which are saprophytes, symbionts, or plant pathogens.Agrobacterium: A genus of gram negative, aerobic, rod-shaped bacteria found in soil, plants, and marine mud.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Adenylosuccinate Synthase: A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.Purine-Pyrimidine Metabolism, Inborn ErrorsSalmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Salmonella enterica: A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.Salmonella Infections, Animal: Infections in animals with bacteria of the genus SALMONELLA.Citric Acid Cycle: A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.Salmonella Infections: Infections with bacteria of the genus SALMONELLA.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Fumarate Hydratase: An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the citric acid cycle enzymes. EC 4.2.1.2.MalatesLeiomyomatosis: The state of having multiple leiomyomas throughout the body. (Stedman, 25th ed)Aconitate Hydratase: An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.Enoyl-CoA Hydratase: An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. EC 4.2.1.17.Silymarin: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Liver Diseases: Pathological processes of the LIVER.Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.Time Factors: Elements of limited time intervals, contributing to particular results or situations.omega-Chloroacetophenone: A potent eye, throat, and skin irritant. One of its uses is as a riot control agent.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Waste Products: Debris resulting from a process that is of no further use to the system producing it. The concept includes materials discharged from or stored in a system in inert form as a by-product of vital activities. (From Webster's New Collegiate Dictionary, 1981)Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Methanobacteriaceae: A family of anaerobic, coccoid to rod-shaped METHANOBACTERIALES. Cell membranes are composed mainly of polyisoprenoid hydrocarbons ether-linked to glycerol. Its organisms are found in anaerobic habitats throughout nature.Methanobrevibacter: A genus of gram-positive, anaerobic, cocci to short rod-shaped ARCHAEA, in the family METHANOBACTERIACEAE, order METHANOBACTERIALES. They are found in the GASTROINTESTINAL TRACT or other anoxic environments.Methanobacteriales: An order of anaerobic, coccoid to rod-shaped methanogens, in the kingdom EURYARCHAEOTA. They are nonmotile, do not catabolize carbohydrates, proteinaceous material, or organic compounds other than formate or carbon monoxide, and are widely distributed in nature.Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Enzymes: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.International Agencies: International organizations which provide health-related or other cooperative services.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Fumarate is then cleaved off forming adenosine monophosphate. This step is catalyzed by adenylosuccinate lyase. Inosine ...
... class of carbon-carbon lyases. The systematic name of this enzyme class is benzylsuccinate fumarate-lyase (toluene-forming). ... toluene and fumarate. This enzyme belongs to the family of lyases, specifically in the "catch-all" ... This enzyme is also called benzylsuccinate fumarate-lyase. This enzyme participates in benzoate degradation via coa ligation. ... fumarate Hence, this enzyme has one substrate, benzylsuccinate, and two products, ...
CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ... GMP GMP reductase converts GMP back into IMP adenylosuccinate synthase converts IMP to adenylosuccinate adenylosuccinate lyase ...
... fumarate-forming). Other names in common use include: fumarase L-malate hydro-lyase (S)-malate hydro-lyase The FH gene is ... Fumarase (or fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. ... This led to the conclusion that in the formation of S-Malate from fumarate E1 elimination, protonation of fumarate to the ... This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic ...
... is a precursor to fumarate in the citric acid cycle via argininosuccinate lyase. Argininosuccinate ...
Fumarate hydratase then catalyses the dehydration of malate to produce fumarate. phosphoenolpyruvate + HCO3 → oxaloacetate + ... This reaction requires the enzyme formate-hydrogen lyase. It can be used to prevent the conditions inside the cell becoming too ... It is catalysed by the enzyme fumarate reductase. fumarate + NADH + H+ → succinate + NAD+ This reduction is an anaerobic ... Vitamin K2, also known as menaquinone, is very important for electron transport to fumarate in E. coli. Formate can be ...
... fumarate reductase, and pyruvate formate lyase. Arc A is regulated by FNR in anaerobic conditions. Anaerobic activation of arcA ... The fnr (fumarate and nitrate reductase) gene of Escherichia coli encodes a transcriptional activator (FNR) which is required ... The FNR (Fumarate and Nitrate reductase Regulatory) protein of E. coli is an oxygen - responsive transcriptional regulator ... Only if neither O2 nor nitrate are available, fumarate reductase and the fermentative enzymes are synthesized. The switch from ...
2Fdox ATP citrate lyase: ACL, acetyl-CoA + oxaloacetate + ADP + Pi ⇌ citrate + CoA + ATP α-keto-glutarate:ferredoxin ... fumarate + reduced acceptor Anoxic event Purple sulfur bacteria Green non-sulfur bacteria Bryant DA, Frigaard NU (November 2006 ...
The fumarate that is produced in step three is also an intermediate in the citric acid cycle and is returned to that cycle. ... 1 carbamoyl phosphate synthetase I OTC Ornithine transcarbamoylase ASS argininosuccinate synthetase ASL argininosuccinate lyase ... The fumarate released in the cytosol is hydrated to malate by cytosolic fumarase. This malate is then oxidized to oxaloacetate ... Thus, the overall equation of the urea cycle is: NH3 + CO2 + aspartate + 3 ATP + 2 H2O → urea + fumarate + 2 ADP + 2 Pi + AMP ...
... pectin lyase EC 4.2.2.11: poly(a-L-guluronate) lyase EC 4.2.2.12: xanthan lyase EC 4.2.2.13: exo-(1-4)-α-D-glucan lyase EC 4.2. ... fumarate hydratase EC 4.2.1.3: aconitate hydratase EC 4.2.1.4: citrate dehydratase EC 4.2.1.5: arabinonate dehydratase EC 4.2. ... pectate lyase EC 4.2.2.3: poly(b-D-mannuronate) lyase EC 4.2.2.4: chondroitin ABC lyase EC 4.2.2.5: chondroitin AC lyase EC 4.2 ... oligogalacturonide lyase EC 4.2.2.7: heparin lyase EC 4.2.2.8: heparin-sulfate lyase EC 4.2.2.9: pectate disaccharide-lyase EC ...
Adenylosuccinate is cleaved by the enzyme adenylosuccinate lyase to release fumarate and regenerate the starting material of ... 1) Synthesis of fumarate Fumarate is an intermediate of TCA cycle and enters the mitochondria by converting into malate and ... The Purine Nucleotide Cycle is a metabolic pathway in which fumarate is generated from aspartate in order to increase the ... to sustain mitochondrial membrane potential during anoxic stress by utilizing fumarate produced by adenylosuccinate lyase as an ...
L-arginine continues through the urea cycle to form urea and ornithine, while fumarate can enter the citric acid cycle. ASL, δ- ... Argininosuccinate lyase is an intermediate enzyme in the urea synthesis pathway and its function is imperative to the ... ASL (argininosuccinate lyase, also known as argininosuccinase) is an enzyme that catalyzes the reversible breakdown of ... GeneReviews/NCBI/NIH/UW entry on Urea Cycle Disorders Overview GeneReviews/NCBI/NIH/UW entry on Argininosuccinate Lyase ...
... fumarate and glycolate. This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that cleave ... fumarate-forming). Other names in common use include carbon-oxygen lyase, and carboxymethyloxysuccinate glycolate-lyase. ... Peterson D, Llaneza J (1974). "Identification of a carbon-oxygen lyase activity cleaving the ether linkage in ... In enzymology, a carboxymethyloxysuccinate lyase (EC 4.2.99.12) is an enzyme that catalyzes the chemical reaction ...
ASL cleaves adenylosuccinate into AMP and fumarate, and cleaves SAICAR into AICAR and fumarate. Adenylosuccinate lyase is part ... Adenylosuccinate lyase converts adenylosuccinate to AMP and fumarate as part of the purine nucleotide cycle. ASL catalyzes two ... Mutated adenylosuccinate lyase (ASL) causes clinical disease in patients that is referred to as adenylosuccinate lyase ... "The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase ...
In the cytosol there are fumarate molecules. Fumarate can be transformed into malate by the actions of the enzyme fumarase. ... It is an anabolic pathway occurring in plants and bacteria utilizing the enzymes isocitrate lyase and malate synthase. Some ...
The family of enzymes to which ADSL belongs and that catalyze β-eliminations in which fumarate is one of the products are ... Treatment of adenylosuccinate lyase deficiency can be done via epilepsy management with anticonvulsive drugs.Additionally the ... "Adenylosuccinate lyase deficiency - Conditions - GTR - NCBI". www.ncbi.nlm.nih.gov. Retrieved 22 December 2016. RESERVED, ... Adenylosuccinate lyase deficiency, also called adenylosuccinase deficiency, is a rare autosomal recessive metabolic disorder ...
... fumarate and NH3. This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds ... The systematic name of this enzyme class is L-aspartate ammonia-lyase (fumarate-forming). Other names in common use include ... In enzymology, an aspartate ammonia-lyase (EC 4.3.1.1) is an enzyme that catalyzes the chemical reaction L-aspartate ⇌ {\ ... displaystyle \rightleftharpoons } fumarate + NH3 Hence, this enzyme has one substrate, L-aspartate, and two products, ...
Aspartate ammonia-lyase, EC 4.3.1.1 (aspartase), which catalyzes the reversible conversion of aspartate to fumarate and ammonia ... A number of enzymes, belonging to the lyase class, for which fumarate is a substrate, have been shown to share a short ... Class I Fumarase enzyme, EC 4.2.1.2 (fumarate hydratase), which catalyzes the reversible hydration of fumarate to L-malate. ... argininosuccinate lyase), which catalyzes the formation of arginine and fumarate from argininosuccinate, the last step in the ...
... succinate is subsequently oxidized to fumarate: Succinate + FAD → Fumarate + FADH2 SDH also participates in the mitochondrial ... The pathway avoids the decarboxylation steps of the TCA cycle via the enzyme isocitrate lyase which cleaves isocitrate into ... Succinate and fumarate inhibit the TET (ten-eleven translocation) family of 5-methylcytosine DNA modifying enzymes and the JmjC ... Accumulation of fumarate can drive the reverse activity of SDH, thus enhancing succinate generation. Under pathological and ...
... tyrosine phenol-lyase MeSH D08.811.520.232.300 --- amidine-lyases MeSH D08.811.520.232.300.200 --- adenylosuccinate lyase MeSH ... fumarate hydratase MeSH D08.811.520.241.300.500 --- phosphopyruvate hydratase MeSH D08.811.520.241.300.500.500 --- tau- ... oxo-acid-lyases MeSH D08.811.520.224.600.200 --- anthranilate synthase MeSH D08.811.520.224.600.700 --- isocitrate lyase MeSH ... ethanolamine ammonia-lyase MeSH D08.811.520.232.400.500 --- histidine ammonia-lyase MeSH D08.811.520.232.400.600 --- l-serine ...
... ammonia lyase (TAL) is an enzyme in the natural phenols biosynthesis pathway. It transforms L-tyrosine into p-coumaric ... Thereby fumarate (also a metabolite of the citric acid cycle) and acetoacetate (3-ketobutyroate) are liberated. Acetoacetate is ... The second utilizes enzymatic synthesis from phenolics, pyruvate, and ammonia through the use of tyrosine phenol-lyase. ...
There it is cleaved by ATP citrate lyase into acetyl-CoA and oxaloacetate. The oxaloacetate is returned to mitochondrion as ... In the citric acid cycle all the intermediates (e.g. citrate, iso-citrate, alpha-ketoglutarate, succinate, fumarate, malate and ... Excess citrate is exported from the mitochondrion back into the cytosol, where ATP citrate lyase regenerates acetyl-CoA and ...
Aspartic acid is produced by the addition of ammonia to fumarate using a lyase.[22] ... Cystathionine-β-lyase (in mammals, this step is performed by homocysteine methyltransferase or betaine-homocysteine S- ...
One was malate synthase, which condenses acetate with glyoxylate to form malate, and the other was isocitrate lyase, which ... One hypothesis involving succinate, fumarate, and malate proved to be useful because all these molecules increased oxygen ...
Prenylcysteine lyase (PCLase) catalyzes the cleavage of prenylcysteine (a protein modification) to form an isoprenoid aldehyde ... requires covalently bound FAD to catalyze the oxidation of succinate to fumarate by coupling it with the reduction of ... Of all flavoproteins, 90% perform redox reactions and the other 10% are transferases, lyases, isomerases, ligases. Monoamine ...
... which catalyzes the oxidation of succinate to fumarate in the Krebs cycle. Malonate is a competitive inhibitor of succinic ... Lyase (EC 4). *4.1 Dopa decarboxylase. *4.2 Carbonic anhydrase. Miscellaneous. *Steroidogenesis inhibitor ...
Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate. ... Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.. * ... Human Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.. ...
Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... Definition: an enzyme catalyzing the nonhydrolytic cleavage of adenylosuccinic acid producing AMP and fumarate and also of 4-(N ... adenylosuccinate lyase. Pronunciation: ad′e-nil-ō-sŭk′sin-āt lī′ās ... succinocarboxamido)-5-aminoimidazole nucleotide to yield fumarate and aminoimidazole carboxamide ribosyl-5-phosphate. Both are ...
Aspartate ammonia-lyase, EC 4.3.1.1 (aspartase), which catalyzes the reversible conversion of aspartate to fumarate and ammonia ... A number of enzymes, belonging to the lyase class, for which fumarate is a substrate, have been shown to share a short ... Class I Fumarase enzyme, EC 4.2.1.2 (fumarate hydratase), which catalyzes the reversible hydration of fumarate to L-malate. ... argininosuccinate lyase), which catalyzes the formation of arginine and fumarate from argininosuccinate, the last step in the ...
Fumarate lyase, conserved site (IPR020557). Short name: Fumarate_lyase_CS Description. A number of enzymes, belonging to the ... P04422: Aspartate ammonia-lyase, EC:4.3.1.1 (aspartase), which catalyses the reversible conversion of aspartate to fumarate and ... P04424: Arginosuccinase, EC:4.3.2.1 (argininosuccinate lyase), which catalyses the formation of arginine and fumarate from ... P05042: Class I Fumarase enzyme, EC:4.2.1.2 (fumarate hydratase), which catalyses the reversible hydration of fumarate to L- ...
... citrate lyase; [64] citrate synthase; [65] fumarate reductase; [66] aconitase; [67] isocitrate dehydrogenase; [68] Fe-Fe ... Numbers in parentheses refer to enzymes as follows: [1] alginate lyase; [2] oligoalginate lyase; [3] endo-xyloglucanase; [4] ... sohal and alginate lyases in Naso species capable of breaking down agar (in red algae) and alginates (in brown algae), ... S6). However, this is largely driven by the lack of alginate lyases for processing alginate polysaccharides of brown algae in ...
The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three ... Fumarate lyase Residues 17-456 266779 10 1C3U 1 A, B ADENYLOSUCCINATE LYASE 2336 4.3.2.2 , Details ...
Fumarate is then cleaved off forming adenosine monophosphate. This step is catalyzed by adenylosuccinate lyase. Inosine ...
... fumarate reductase; fum, fumarase; icd, isocitrate dehydrogenase; icl, isocitrate lyase; kgd, -ketoglutarate dehydrogenase; ldh ... Both oxaloacetate and malate may be further converted to fumarate by malate dehydrogenase (mdh) and fumarase (fum). Fumarate ... S. Meijer, J. Otero, R. Olivares, M. R. Andersen, L. Olsson, and J. Nielsen, "Overexpression of isocitrate lyase-glyoxylate ... V. Coustou, S. Besteiro, L. Rivière et al., "A mitochondrial NADH-dependent fumarate reductase involved in the production of ...
IPR020557 Fumarate_lyase_CS. IPR000362 Fumarate_lyase_fam. IPR022761 Fumarate_lyase_N. IPR008948 L-Aspartase-like. ... IPR020557 Fumarate_lyase_CS. IPR000362 Fumarate_lyase_fam. IPR022761 Fumarate_lyase_N. IPR008948 L-Aspartase-like. ... Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation. Manual assertion according to rulesi ... IPR029419 Arg_succ_lyase_C. IPR009049 Argininosuccinate_lyase. IPR024083 Fumarase/histidase_N. ...
IPR020557 Fumarate_lyase_CS. IPR000362 Fumarate_lyase_fam. IPR022761 Fumarate_lyase_N. IPR008948 L-Aspartase-like. IPR004769 ... IPR020557 Fumarate_lyase_CS. IPR000362 Fumarate_lyase_fam. IPR022761 Fumarate_lyase_N. IPR008948 L-Aspartase-like. IPR004769 ... Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB_1), Adenylosuccinate lyase (pcaB_2), Adenylosuccinate lyase (EA770_ ... Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB_1), Adenylosuccinate lyase (pcaB_2), Adenylosuccinate lyase (EA770_ ...
... formate hydrogen lyase complex; FRD, fumarate reductase; GlyD, glycerol dehydratase; glyDH, glycerol dehydrogenase; glpF, ... formate hydrogen lyase complex; FRD, fumarate reductase; GlyD, glycerol dehydratase; glyDH, glycerol dehydrogenase; glpF, ... Chemical intermediates and products: DHA, dihydroxyacetone; DHAP, dihydroxyacetone phosphate; FUM, fumarate; GAL3P, ... Chemical intermediates and products: DHA, dihydroxyacetone; DHAP, dihydroxyacetone phosphate; FUM, fumarate; GAL3P, ...
... fumarate hydratase; FHL, formate hydrogen lyase; FRD, fumarate reductase; HYD, hydrogenase; ICL, Isocitrate lyase; IDH, ... Macy, J., Schröder, I., Thauer, R., and Kröger, A. (1986). Growth the Wolinella succinogenes on H2S plus fumarate and on ... Moreover, all the genomes possess the gene encoding pyruvate:formate lyase (PFL), involved in pyruvate metabolism and leading ... ACK, acetate kinase; ACLY, ATP citrate lyase; ACS, acetyl-CoA synthetase; CS, citrate synthase; DSR, Dissimilatory sulfite ...
Adenylosuccinate Lyase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... fumarate-forming) activity and (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate- ... lyase activity. IEA. --. GO:0070626. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase ( ... N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. IEA,IDA. 16973378. ...
... fumarate reductase (frdABCD); FUM, fumarase (fumA fumB fumC); MDH, malate dehydrogenase (mdh); ICL, isocitrate lyase (aceA); MS ... fumarate or Na·α-ketoglutarate. Although supplementation of NO·-exposed 14028s with either citrate or isocitrate has a general ...
... lyase_CS. DR InterPro; IPR000362; Fumarate_lyase_fam. DR InterPro; IPR022761; Fumarate_lyase_N. DR InterPro; IPR008948; L- ... lyase; 1. DR InterPro; IPR029419; Arg_succ_lyase_C. DR InterPro; IPR009049; Argininosuccinate_lyase. DR InterPro; IPR024083; ... DR SUPFAM; SSF48557; SSF48557; 1. DR TIGRFAMs; TIGR00838; argH; 1. DR PROSITE; PS00163; FUMARATE_LYASES; 1. PE 3: Inferred from ... Belongs to the lyase 1 family. Argininosuccinate lyase CC subfamily. {ECO:0000255,HAMAP-Rule:MF_00006}. DR EMBL; CP000633; ...
Fumarate_lyase_fam. DR InterPro; IPR022761; Fumarate_lyase_N. DR InterPro; IPR008948; L-Aspartase-like. DR Pfam; PF10397; ADSL_ ... DR Gene3D; 1.10.275.10; -; 1. DR InterPro; IPR019468; AdenyloSucc_lyase_C. DR InterPro; IPR024083; Fumarase/histidase_N. DR ... C; 1. DR Pfam; PF00206; Lyase_1; 1. DR PRINTS; PR00149; FUMRATELYASE. DR SMART; SM00998; ADSL_C; 1. DR SUPFAM; SSF48557; ...
... or fumarate hydratase/lyase) is linked to downstream genes orfX (of unknown function) and sodA (encodes Mn-cofactored Sod) in ... fumarate lyase (FumC, Pput 0984), the antioxidative enzyme superoxide dismutase (Fe-Mn family, Pput 0985), haem oxygenase (Pput ... fumarate lyase (Pput 0984), superoxide dismutase (Pput 0985), a TonB-dependent hemoglobin/transferrin/lactoferrin family ... an iron-responsive operon [32]. Fumarase catalyzes the reversible conversion of fumarate to malate in the TCA cycle and has ...
Fhl for formate hydrogen lyase; FrdABCD for fumarate reductase; FumB for fumarase B (anaerobic); FumC for fumarase C; Ldh for ... In the latter reaction, malate is converted to fumarate by FUM and the fumarate is reduced to succinate (Figure 6); this ... 2006). Pyruvate formate-lyase and a novel route of eukaryotic ATP synthesis in Chlamydomonas mitochondria. J. Biol. Chem. 281, ... The pyruvate can be converted to formate and acetyl-coenzyme A (acetyl-CoA) by pyruvate formate lyase (Pfl; Wolfe, 2005; Figure ...
... argininosuccinate lyase; Arg1, arginase 1; Fh1, fumarate hydratase 1; Mdh2, malate dehydrogenase 2; Acly, ATP citrate lyase; ... These two enzymes will facilitate the generation of fumarate and urea. Fumarate further enters the citrate cycle and, together ...
Fumarate Hydratase: An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the ... Lyases: 25*Carbon-Oxygen Lyases*Hydro-Lyases: 12*Fumarate Hydratase: 192*Fumaric aciduria: 18 ... Fumarate Hydratase (Fumarase). Subscribe to New Research on Fumarate Hydratase An enzyme that catalyzes the reversible ... 12/08/2014 - "DisABLing kidney cancers caused by fumarate hydratase mutations.". 01/01/2011 - "Reduced expression of fumarate ...
The fourth step involves the cleavage of argininosuccinate to form fumarate and arginine. Argininosuccinate lyase is the enzyme ... Argininosuccinate → arginine + fumarate. *In the fifth and last step of the urea cycle, arginine is hydrolyzed to form urea and ...
Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells. Cancer Metab. 1, 12 (2013).. ... 4K). While argininosuccinate lyase (ASL) produces arginine and fumarate from argininosuccinate in the urea cycle, we ... In addition, their arginine concentrations reverse the urea cycle reaction catalyzed by argininosuccinate lyase, an effect not ... The reversal of the ASL-catalyzed reaction has been previously reported in fumarate hydratase-deficient cells, where the high ...
The enzyme argininosuccinate lyase converts argininosuccinate to arginine and fumarate (Supplemental Figure 9). We found that ... Despite high fumarate levels, we found no changes in malate or oxaloacetate levels in liver. However, the alternative ... liver arginine levels were reduced, presumably as a result of high arginase activity, while fumarate levels were elevated ( ...
SAICAR => AICAR + Fumarate (Canis familiaris) * adenylosuccinate lyase tetramer [cytosol] (Canis familiaris) * Homologues of ... adenylosuccinate => adenosine 5-monophosphate + fumarate (Canis familiaris) * adenylosuccinate lyase tetramer [cytosol] (Canis ...
DR InterPro; IPR024083; Fumarase/histidase_N. DR InterPro; IPR000362; Fumarate_lyase_fam. DR InterPro; IPR022761; Fumarate_ ... lyase; 1. DR InterPro; IPR029419; Arg_succ_lyase_C. DR InterPro; IPR009049; Argininosuccinate_lyase. ... Belongs to the lyase 1 family. Argininosuccinate lyase CC subfamily. {ECO:0000255,HAMAP-Rule:MF_00006}. DR EMBL; CP000102; ... Lyase; Reference proteome. FT CHAIN 1 465 Argininosuccinate lyase. FT /FTId=PRO_0000240791. SQ SEQUENCE 465 AA; 52209 MW; ...
  • an enzyme catalyzing the nonhydrolytic cleavage of adenylosuccinic acid producing AMP and fumarate and also of 4-( N- succinocarboxamido)-5-aminoimidazole nucleotide to yield fumarate and aminoimidazole carboxamide ribosyl-5-phosphate. (drugs.com)
  • Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. (genecards.org)
  • Polysaccharide lyases (EC 4.2.2.x) are carbon-oxygen lyases that harness β-elimination chemistry (reviewed in ref. 1 ) to bring about degradation of C5 uronic acid containing pyranoside substrates such as polygalacturonates, alginates, hyaluronan, and chondroitin. (pnas.org)
  • A number of enzymes, belonging to the lyase class, for which fumarate is a substrate, have been shown to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this type of enzymes. (wikipedia.org)
  • (genome.jp)
  • The three-dimensional crystal structure of the catalytic module of a "family PL-10" polysaccharide lyase, Pel10Acm from Cellvibrio japonicus , solved at a resolution of 1.3 Å, reveals a new polysaccharide lyase fold and is the first example of a polygalacturonic acid lyase that does not exhibit the "parallel β-helix" topology. (pnas.org)
  • The "Michaelis" complex of an inactive mutant in association with the substrate trigalacturonate/Ca 2+ reveals the catalytic machinery harnessed by this polygalacturonate lyase, which displays a stunning resemblance, presumably through convergent evolution, to the tetragalacturonic acid complex observed for a structurally unrelated polygalacturonate lyase from family PL-1. (pnas.org)
  • Here we report the 1.3-Å resolution three-dimensional structure of the competent catalytic module of the polygalacturonic acid lyase Pel10A (Pel10Acm), from Cellvibrio japonicus, together with analysis of the activity of wild-type and mutant enzymes. (pnas.org)
  • The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid. (embl.de)
  • However, the mutant E. coli strains deficient in ldhA (coding lactate dehydrogenase) and pflB (coding pyruvate-formate lyase), adhE (coding alcohol dehydrogenase) and pta (coding phosphotransacetylase) or their combinations were unable to anaerobically grow on glucose media and the titer and yield of succinate were relatively low. (biomedcentral.com)
  • 2VD6: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate. (rcsb.org)
  • In contrast to the 87 sequence-derived families of glycoside hydrolases, polysaccharide lyases have been classified into just 12 families on the basis of amino acid sequence similarities ( 5 ), reflecting the requirement for substrate uronic acid groups in the elimination mechanism. (pnas.org)