5,7,3',4'-tetrahydroxy-flavone, one of the FLAVONES.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.
The possession of a third chromosome of any one type in an otherwise diploid cell.
A group of FLAVONOLS based on kaempferol. They are derived from naringenin and can be hydroxylated to QUERCETIN or reduced to leucopelargonidin.
A characteristic symptom complex.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
A plant genus of the family ASTERACEAE. Members contain chicoric and chlorogenic acids and germacrane- and eudesmane-type SESQUITERPENES.
A plant genus of the family SIMAROUBACEAE. Members contain ailantinols and other quassinoids.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
The reproductive organs of plants.
Asexual reproduction resulting in the formation of viable seeds from FLOWERS without fertlization (i.e. use of POLLEN). Progeny plants produced from apomictic seeds are perfect clones of the parent.
An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
An enzyme of the lyase class that catalyzes the conversion of ATP and oxaloacetate to ADP, phosphoenolpyruvate, and carbon dioxide. The enzyme is found in some bacteria, yeast, and Trypanosoma, and is important for the photosynthetic assimilation of carbon dioxide in some plants. EC 4.1.1.49.
5,7,4'-trihydroxy-flavone, one of the FLAVONES.
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
A group of 4-keto-FLAVONOIDS.
An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoenolpyruvate, and carbon dioxide. This reaction is part of gluconeogenesis in the liver. The enzyme occurs in both the mitochondria and cytosol of mammalian liver. (From Dorland, 27th ed) EC 4.1.1.32.
A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. Mutations in HNF-3beta have been associated with CONGENITAL HYPERINSULINISM.

Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. (1/177)

The protective effect of flavonoids against linoleic acid hydroperoxide (LOOH)-induced cytotoxicity was examined by using cultured endothelial cells. When the cells were incubated with both LOOH and flavonoids, most flavonols protected the cells from injury by LOOH. Flavones bearing an ortho-dihydroxy structure also showed a protective effect against the cytotoxicity of LOOH. However, flavanones had no effect. The structure-activity relationship revealed the presence of either the ortho-di-hydroxy structure in the B ring of the flavonoids or 3-hydroxyl and 4-oxo groups in the C ring to be important for the protective activities. The interaction between flavonoids and a-tocopherol was also examined in this system. Flavonoids that were protective against LOOH-induced cytotoxicity had at least an additive effect on the action of alpha-tocopherol against LOOH-induced damage.  (+info)

Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. (2/177)

1. Flavonoids display a wide range of pharmacological properties including anti-inflammatory. Anti-mutagenic, anti-carcinogenic and anti-cancer effects. Here, we evaluated the effects of eight flavonoids on the tumour cell proliferation, cellular protein phosphorylation, and matrix metalloproteinase (MMPs) secretion. 2. Of the flavonoids examined, luteolin (Lu) and quercetin (Qu) were the two most potent agents, and significantly inhibited A431 cell proliferation with IC50 values of 19 and 21 micronM, respectively. 3. The epidermal growth factor (EGF) (10 nM) promoted growth of A431 cells (+25+/-4.6%) and mediated epidermal growth factor receptor (EGFR) tyrosine kinase activity and autophosphorylation of EGFR were inhibited by Lu and Qu. At concentration of 20 micronM, both Lu and Qu markedly decreased the levels of phosphorylation of A431 cellular proteins, including EGFR. 4. A431 cells treated with Lu or Qu exhibited protuberant cytoplasmic blebs and progressive shrinkage morphology. Lu and Qu also time-dependently induced the appearance of a ladder pattern of DNA fragmentation, and this effect was abolished by EGF treatment. 5. The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase. 6. EGF increased the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), while Lu and Qu appeared to suppress the secretion of these two MMPs in A431 cells. 7. Examination of the relationship between the chemical structure and inhibitory effects of eight flavonoids reveal that the double bond between C2 and C3 in ring C and the OH groups on C3' and C4' in ring B are critical for the biological activities. 8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory effects of EGF, on tumour cell proliferation, cellular protein phosphorylation, and MMP secretion may be mediated at least partly through EGFR. This study supports the idea that Lu and Qu may have potential as anti-cancer and anti-metastasis agents.  (+info)

Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. (3/177)

BACKGROUND: Plant-derived flavonoids, which occur abundantly in our daily dietary intake, possess antitumor, antibacterial, and free radical scavenging properties. They form active constituents of a number of herbal and traditional medicines. Several flavonoids have been shown to exert their action by interacting with DNA topoisomerases and promoting site-specific DNA cleavage. Therefore, flavonoids are potential candidates in drug design. We report here that, although the flavonoids luteolin and quercetin are potent antileishmanial agents, luteolin has great promise for acting as a lead compound in the chemotherapy of leishmaniasis, a major concern in developing countries. MATERIALS AND METHODS: Kinetoplast DNA (kDNA) minicircle cleavage in drug-treated parasites was measured by electrophoresis of the total cellular DNA, followed by Southern hybridization using 32P labeled kDNA as a probe. Cell cycle progression and apoptosis were measured by flow cytometry using propidium iodide and fluorescein isothiocyanate (FITC)-labeled Annexin V. RESULTS: Luteolin and quercetin inhibited the growth of Leishmania donovani promastigotes and amastigotes in vitro, inhibited DNA synthesis in promastigotes, and promoted topoisomerase-II-mediated linearization of kDNA minicircles. The IC50 values of luteolin and quercetin were 12.5 microM and 45.5 microM, respectively. These compounds arrest cell cycle progression in L. donovani promastigotes, leading to apoptosis. Luteolin has no effect on normal human T-cell blasts. Both luteolin and quercetin reduced splenic parasite burden in animal models. CONCLUSION: Luteolin and quercetin are effective antileishmanial agents. Quercetin has nonspecific effects on normal human T cells, but luteolin appears nontoxic. So, luteolin can be a strong candidate for antileishmanial drug design.  (+info)

Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. (4/177)

We investigated the growth inhibitory activity of several flavonoids, including apigenin, luteolin, kaempherol, quercetin, butein, isoliquiritigenin, naringenin, genistein, and daizein against B16 mouse melanoma 4A5 cells. Isoliquiritigenin and butein, belonging to the chalcone group, markedly suppressed the growth of B16 melanoma cells and induced cell death. The other flavonoids tested showed little growth inhibitory activity and scarcely caused cell death. In cells treated with isoliquiritigenin or butein, condensation of nuclei and fragmentation of nuclear DNA, which are typical phenomena of apoptosis, were observed by Hoechst 33258 staining and by agarose gel electrophoresis of DNA. Flowcytometric analysis showed that isoliquiritigenin and butein increased the proportion of hypodiploid cells in the population of B16 melanoma cells. These results demonstrate that isoliquiritigenin and butein inhibit cell proliferation and induce apoptosis in B16 melanoma cells. Extracellular glucose decreased the proportion of hypodiploid cells that appeared as a result of isoliquiritigenin treatment. p53 was not detected in cells treated with either of these chalcones, however, protein of the Bcl-2 family were detected. The level of expression of Bax in cells treated with either of these chalcones was markedly elevated and the level of Bcl-XL decreased slightly. Isoliquiritigenin did not affect Bcl-2 expression, but butein down-regulated Bcl-2 expression. From these results, it seems that the pathway by which the chalcones induce apoptosis may be independent of p53 and dependent on proteins of the Bcl-2 family. It was supposed that isoliquiritigenin induces apoptosis in B16 cells by a mechanism involving inhibition of glucose transmembrane transport and promotion of Bax expression. On the other hand, it was suggested that butein induces apoptosis via down-regulation of Bcl-2 expression and promotion of Bax expression. This mechanism differs from the isoliquiritigenin induction pathway.  (+info)

Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. (5/177)

Flavonoids are naturally occurring polyphenolic compounds with a wide distribution throughout the plant kingdom. In the present study, we compared the ability of several flavonoids to modulate the production of proinflammatory molecules from lipopolysaccharide (LPS)-stimulated macrophages and investigated their mechanism(s) of action. Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and interleukin-6 release, whereas eriodictyol and hesperetin only inhibited TNF-alpha release. From the compounds tested luteolin and quercetin were the most potent in inhibiting cytokine production with an IC(50) of less than 1 and 5 microM for TNF-alpha release, respectively. To determine the mechanisms by which flavonoids inhibit LPS signaling, we used luteolin and determined its ability to interfere with total protein tyrosine phosphorylation as well as Akt phosphorylation and nuclear factor-kappaB activation. Pretreatment of the cells with luteolin attenuated LPS-induced tyrosine phosphorylation of many discrete proteins. Moreover, luteolin inhibited LPS-induced phosphorylation of Akt. Treatment of macrophages with LPS resulted in increased IkappaB-alpha phosphorylation and reduced the levels of IkappaB-alpha. Pretreatment of cells with luteolin abolished the effects of LPS on IkappaB-alpha. To determine the functional relevance of the phosphorylation events observed with IkappaB-alpha, macrophages were transfected either with a control vector or a vector coding for the luciferase reporter gene under the control of kappaB cis-acting elements. Incubation of transfected RAW 264.7 cells with LPS increased luciferase activity in a luteolin-sensitive manner. We conclude that luteolin inhibits protein tyrosine phosphorylation, nuclear factor-kappaB-mediated gene expression and proinflammatory cytokine production in murine macrophages.  (+info)

Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. (6/177)

Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.  (+info)

In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. (7/177)

The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and antitumor promoting agent. In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the polyhydroxyflavonoid (PHF), luteolin (LT). NOB preferentially accumulated in a differentiated Caco-2 cell monolayer, which is a model for small intestinal epithelial cells, while LT did not. Treatment of NOB with a rat liver S-9 mixture led to the formation of 3'-demethyl-NOB, while that of LT did not. We thus suggest that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro.  (+info)

Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. (8/177)

In this study, we investigated whether luteolin monoglucuronide was converted to free aglycone during inflammation using human neutrophils stimulated with ionomycin/cytochalasin B and rats treated with lipopolysaccharide (LPS). beta-Glucuronidase activity was assayed using 4-methylumbelliferyl-glucuronide and methanol extracts of rat plasma containing luteolin monoglucuronide. The released 4-methylumbelliferone, a fluorescent molecule, was quantified by fluorometry. Deglucuronidation of luteolin monoglucuronide was examined by high-performance liquid chromatography (HPLC) analysis. HPLC analyses showed that the supernatants obtained from neutrophils stimulated with ionomycin/cytochalasin B hydrolyzed luteolin monoglucuronide to free luteolin. beta-Glucuronidase activity in human serum from patients on hemodialysis increased significantly compared with that from healthy volunteers. The beta-glucuronidase activity in rat plasma increased after i.v. injection of LPS. The ratio of luteolin to luteolin monoglucuronide in plasma of LPS-treated rats also increased. These results suggest that during inflammation beta-glucuronidase is released from stimulated neutrophils or certain injured cells and then deglucuronidation of flavonoids occurs.  (+info)

Luteolin (3,4,5,7-tetrahydroxyflavone) is a common diet flavonoid, which includes been proven to exert anticancer results in multiple cancers models. was proven to participate in these procedures. The outcomes of todays study demonstrated which the flavonoid luteolin decreased the migration of glioblastoma cells by changing p-IGF-1R/PI3K/AKT/mTOR activation, and could have got potential applications for chemoprevention within a scientific setting. strong course=kwd-title Keywords: luteolin, glioblastoma, migration, epithelial-mesenchymal changeover, phosphorylated insulin-like development aspect-1 receptor/phosphoinositide 3-kinase/proteins kinase B/mammalian focus on of rapamycin Launch Glioblastoma multiforme (GBM) may be the most common malignant principal human brain tumors in human beings (1). A significant quality of GBM may be the capability to invade regular, healthy brain tissues, which creates brand-new malignant foci and leads to low total resection and a higher recurrence price, ...
Sigma-Aldrich offers abstracts and full-text articles by [Irina Iakovleva, Afshan Begum, Malgorzata Pokrzywa, Malin Walfridsson, A Elisabeth Sauer-Eriksson, Anders Olofsson].
TY - JOUR. T1 - RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin. AU - Lin, Cheng Wei. AU - Lai, Gi Ming. AU - Chen, Ku Chung. AU - Lin, Tsung Han. AU - Fan, Jhen Jia. AU - Hsu, Rhu Long. AU - Chou, Chih Ming. AU - Lin, Chun Mao. AU - Kandaswami, Chithan C.. AU - Lee, Ming Ting. AU - Cheng, Chia Hsiung. PY - 2015/12/1. Y1 - 2015/12/1. N2 - The dietary flavonoids luteolin and quercetin are reported to inhibit cancer mobility; however, the regulatory effect of luteolin and quercetin on RPS12 is still unclear. Here, we found that A431-III cells expressed a higher level of RPS12 than A431-P cells. The flavonoids luteolin and quercetin reduced RPS12 and c-Myc expressions via Akt/mTOR signalling. The Akt inhibitor LY294002 and mTOR inhibitor rapamycin reduced RPS12 and c-Myc expressions. The c-Myc inhibitor 10058-F4 reduced RPS12 expression and promoter transactivation. The overexpression of c-Myc increased RPS12 ...
Studies have shown that the natural flavonoid luteolin has neurotrophic activity. In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. Ts65Dn mice, which are frequently used as a model of Down syndrome, were intraperitoneally injected with 10 mg/kg luteolin for 4 …
Fingerprint Dive into the research topics of Dietary flavonoids luteolin and quercetin inhibit migration and invasion of squamous carcinoma through reduction of src/stat3/s100a7 signaling. Together they form a unique fingerprint. ...
The effectiveness of luteolin in diminishing clinical symptoms in crEAE rats after its onset was evaluated by treating crEAE animals with 50 mg/kg luteolin after the first clinical episode, from day 15 onwards. Clinical symptoms were completely abolished within 5 d of luteolin administration, whereas vehicle-treated crEAE animals suffered a severe relapse (Fig. 3 B). Upon ending treatment at day 24, luteolin-treated rats remained free of clinical symptoms until day 27, after which disease developed and progressed to become as severe as that in control crEAE animals (n = 5; not depicted). This indicates that the continuous presence of luteolin will be required to maintain suppression of crEAE.. As shown for the acEAE model (Fig. 1, C and D), luteolin treatment reduced the infiltration of leukocytes into the CNS in crEAE when treatment was started both at day 6 and at day 15. Significantly reduced numbers of macrophages (P , 0.05; Fig. 3 C) and T cells (P , 0.05; not depicted) were found in the ...
The researchers then measured and compared the number of cancer cells present after one, two and three days, across all the exposure groups. The researchers compared the average number of cells, and determined whether or not there was a statistically significant difference in the number of cells present in each group.. The researchers also carried out a variety of experiments to determine what components of the IGF-IR pathway luteolin interferes with.. When assessing the effect of luteolin on the growth of bowel cancer cells, the researchers found that the cells exposed to only IGF-I significantly increased in number, while those exposed to only luteolin significantly reduced in number. The group exposed to both luteolin and IGF-I showed the same reduction in the number of cells as the luteolin-only group, implying that luteolin interferes with the effect of IGF-I.. They also found that luteolin reduces the secretion of a protein called IGF-II by the cancer cells, reduces the amount of a key ...
The researchers then measured and compared the number of cancer cells present after one, two and three days, across all the exposure groups. The researchers compared the average number of cells, and determined whether or not there was a statistically significant difference in the number of cells present in each group.. The researchers also carried out a variety of experiments to determine what components of the IGF-IR pathway luteolin interferes with.. When assessing the effect of luteolin on the growth of bowel cancer cells, the researchers found that the cells exposed to only IGF-I significantly increased in number, while those exposed to only luteolin significantly reduced in number. The group exposed to both luteolin and IGF-I showed the same reduction in the number of cells as the luteolin-only group, implying that luteolin interferes with the effect of IGF-I.. They also found that luteolin reduces the secretion of a protein called IGF-II by the cancer cells, reduces the amount of a key ...
467 Prostate cancer (PCa) has become one of the most frequently diagnosed malignancies in the United States with similar trend in most Western countries. The substantial mortality and morbidity associated with PCa and its poor treatment options have led a surge to develop novel means for its prevention. The development of chemoprevention strategies against PCa would have huge impact, both medically and economically. Because of its ubiquity and disease burden, PCa is an attractive target for chemoprevention. Fisetin (3,3,4,7-tetrahydroxyflavone), is found in fruits andvegetables, such as strawberry, apple, persimmon, grape, onionand cucumber. The aim of this study was to determine the effect of fisetin on cell-growth and apoptosis in human PCa cells. Treatment of fisetin (10-60 μM; 48 h) was found to result in a decrease in the viability of LNCaP, CWR22Rυ1 and PC-3 cells but had only minimal effect on normal prostate epithelial PrEC cells as assessed by MTT assay. To decipher the mechanism of ...
Learn more about luteolin-7-3-di-o-glucoside. We enable science by offering product choice, services, process excellence and our people make it happen.
Both reactive oxygen- and nitrogen-derived reactive species play important roles in physiological and pathophysiological conditions. Flavones, luteolin and luteolin-7-O-glucoside along with a rich...
Quercetin (QUE; 3,5,7,3′,4′-tetrahydroxyflavone) has been shown to possess several beneficial biological activities including antitumor, anti-inflammation and antioxidant properties; however, the effects of QUE in preventing invasion by breast carcinoma cells are still undefined. Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin. A translocation of protein kinase C (PKC)δ from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCδ inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin). Application of QUE significantly suppressed TPA-induced activation ...
In the present work we investigated the banana peels (|i|Musa cavendishii|/i|) of organic silk variety from Pachacamac (Lurín, Lima) for being waste contaminants without use that avoid the damage to the environment. The qualitative presence of polyphenols and flavonoids was determined by phytochemical marching developed in ethanol extract of banana peels. Using thin layer chromatography on an analytical and preparative scale and rapid column chromatography, it was possible to separate nine soluble fractions in methanol and five soluble fractions in double distilled water as well as their respective Rf values; and by UV-visible spectrophotometry were elucidated nine structures of methanol soluble flavones (5,7-dihydroxy-4-methoxyflavone, 4,5,6,7-tetrahydroxyflavone, 5,7-dihydroxy-6-methoxyflavone, 4,5,7,8-tetrahydroxyflavone; 5,7,8-trihydroxyflavone, 45,7-trihydroxyflavone; 5,6-dihydroxy-7-methoxyflavone, 5,6,7-trihydroxy-4-methoxyflavone and 5,7-dihydroxy-4,6-dimethoxyflavone) and two flavones
...Plant-based diets are healthy. Plants are high in flavonoids. So flavo... Even outside these specific findings with cancer what were saying i...His study explored the effects of the flavonoids luteolin and querceti...Nordeen and colleagues show that luteolin blocks some of the endocrine...,Common,autism,supplement,affects,endocrine,system,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Buy Tetrahydroxyl diphenylethylene-2-o-glucoside,Tetrahydroxyl diphenylethylene-2-o-glucoside Suppliers,Tetrahydroxyl diphenylethylene-2-o-glucoside Prices,We Provide the most accurate Tetrahydroxyl diphenylethylene-2-o-glucoside quotations as well as Tetrahydroxyl diphenylethylene-2-o-glucoside prices.Welcome to contact us,Email:[email protected]
You may also wish to search for items by Zheng, X. and Zheng. Only one matching reference was found. Sun, Q.-L.; Hua, S.; Ye, J.-H.; Zheng, X.-Q.; Liang, Y.-R., Flavonoids and volatiles in Chrysanthemum morifolium Ramat flower from Tongxiang County in China, Afr. J. Biotechnol., 2010, 9, 25, 3817-3821. [all data] ...
TY - CHAP. T1 - Effects of flavonoids on the vascular endothelium: What is known and what is next?. AU - Weseler, A.R.. AU - Bast, A.. PY - 2012/1/1. Y1 - 2012/1/1. M3 - Chapter. SP - 309. EP - 330. BT - Flavonoids and related compounds. Bioavailability and function.. A2 - Spencer, J.P.E.. A2 - Crozier, A.. PB - CRC Press. ER - ...
ALB Technology Limited provides 2,3,5,4-tetrahydroxyl diphenylethylene-2-O-glucoside | CAS Number: 82373-94-2 at competitive price. | Reference Standard., ALB-RS-0092, 2,3,5,4-tetrahydroxyl diphenylethylene-2-O-glucoside, 82373-94-2,
Attinenze scientifiche: propriet sedative, antispasmodiche, calmanti; con azione favorevole in caso di nervosismo, insonnia, spasmi in genere, mestruazioni dolorose, turbe della menopausa, ecc.; stomachico, carminativo; indigestione, crampi di stomaco, meteorismo; influenza, febbre, raffreddore; coleretico, diuretico, diaforetico, rinfrescante, antivirale, vulnerario; uso locale a giusta diluizione dellolio essenziale: frizioni stimolanti sui muscoli intorpiditi e contro cefalee, aggiunto al bagno come blando emmenagogo, applicato sulle ferite come disinfettante e cicatrizzante. Contenuto naturale: olio essenziale (citrale (geraniale e nerale) circa 10-20%, citronellale, geraniolo, eugenilacetato; cis e trans-beta-ocimene; linalolo, citronellolo; beta-cariofillene, alfa-cubebene, copaene, beta-bourbonene); flavonoidi (luteolin-7-glucoside, ramnazina); acidi fenolici (caffeico, protocatechico, rosmarinico, clorogenico); triterepeni (acido oleanolico e ursolico); mucillagini (12% nelle foglie) ...
ChemFaces is Reference Standard and high-purity Natural Products Manufacturer of Isomucronulatol 7-O-glucoside(CFN93256) CAS no.:94367-43-8
We have 1195 words starting with QU. If you're looking for a word definitions starting with the QU then check out our words below.. These are useful for Scrabble and other word games. ...
We examine the effects of high-glucose (HG) and flavonoids on ICAM-1 in HUVECs. ► HG increased the levels of ICAM-1 in HUVECs. ► Pretreatment with flavonoids ...
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Este módulo explora la variedad de reacciones químicas agrupándolos en tipos generales. Miremos la síntesis, descomposición, reemplazo singular, doble reemplazo doble, REDOX (incluyendo combustión) y reacciones de acido y base, con ejemplos de cada uno.
Ciprofloxacino dose cachorro - valitsev mju, ritegevus toimub eestis. arvestades koondumise osaliste tekkivat turuosa, konkurentide.
1970, c. 37, s. 52; 1971, c. 47, s. 13; 1973, c. 46, s. 43, s. 44, s. 49; 1973, c. 49, s. 40, s. 41, s. 45; 1973, c. 51, s. 39, s. 40, s. 46; 1973, c. 52, s. 27, s. 28, s. 31; 1977, c. 5, s. 229; 1979, c. 1, s. 41; 1979, c. 77, s. 34; 1979, c. 63, s. 329; 1979, c. 45, s. 150; 1981, c. 9, s. 7; 1981, c. 22, s. 20; 1982, c. 53, s. 57; 1984, c. 47, s. 209; 1985, c. 21, s. 18; 1985, c. 23, s. 24; 1986, c. 95, s. 20; 1988, c. 41, s. 88; 1988, c. 82, s. 215; 1990, c. 19, s. 11; 1991, c. 42, s. 577; 1992, c. 19, s. 6; 1991, c. 42, s. 577; 1992, c. 44, s. 81; 1992, c. 21, s. 108, s. 375; 1993, c. 51, s. 17; 1994, c. 8, s. 12; 1994, c. 12, s. 16; 1994, c. 15, s. 34; 1994, c. 16, s. 50; 1994, c. 17, s. 76; 1994, c. 40, s. 457; 1996, c. 29, s. 43; 1996, c. 21, s. 33; 1997, c. 63, s. 128; 1997, c. 73, s. 90; 1998, c. 39, s. 180; 1999, c. 36, s. 37; 1999, c. 89, s. 33, s. 42; 2001, c. 24, s. 105; 2001, c. 44, s. 30; 2002, c. 66, s. 20; 2004, c. 11, s. 62; 2005, c. 11, s. 22; 2005, c. 24, s. 22; 2005, c. 28, ...
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When I was a mere toddler, my great-uncle used to tell me lies are fun|stories about Rawhead and Bloodybones, two terrible bugbears&qu...
Mnoge biljne vrste sadrže različite aktivne supstancije koje mogu pomoći pri liječenju ili ublažavanju simptoma određenih bolesti. Jedna vrsta takvih aktivnih tvari su polifenoli, za koje u posljednje vrijeme raste zanimanje upravo zbog brojnih znanstvenih dokaza o njihovom pozitivnom učinku na zdravlje. U ovom radu korištena je tekućinska kromatografija visoke djelotvornosti (HPLC) za kvalitativnu i kvantitativnu analizu polifenola u tri biljne vrste: Sambucus nigra, Artmisiia absinthium i Achillea millefolium. Detekcija ispitivanih polifenola izvršena je pomoću DAD detektora. U etanolnom ekstraktu biljne vrste Achillea millefolium pronađena je klorogenska kiselina, ružmarinska kiselina, ferulična kiselina te flavonoid luteolin, dok su u vodenom ekstraktu pronađene ferulična kiselina, klorogenska kiselina te ružmarinska kiselina. U etanolnom ekstraktu biljne vrste Sambucus nigra pronađene su klorogenska kiselina, ružmarinska kiselina te ferulična kiselina, a u vodenom ...
The flowers of Chrysanthemum morifolium were extracted with 5% sodium hydroxide, yielding a neutral polysaccharide (JHB0S2) with a molecular weight of 16 kDa by anion-exchange chromatography on a DEAE-cellulose column and gel permeation chromatography on a Sephacryl S-200 HR column. JHB0S2 was found …
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Low prices on Chrysin! Anti-aromatase chrysin unlocks more testosterone power. Chrysin is a plant flavonoid that can influence the enzymatic conversion of testosterone to estrogen. In this way, chrysin may optimize testosterone activity while minimizing its conversion to estrogen.*
Create an overview of the optimal primers print(summary(optimal.primers$opti)) #, Iteration Marginal_Coverage_Gain Cumulative_Coverage #, Min. :1 Min. :2 Min. :2 #, 1st Qu.:1 1st Qu.:2 1st Qu.:2 #, Median :1 Median :2 Median :2 #, Mean :1 Mean :2 Mean :2 #, 3rd Qu.:1 3rd Qu.:2 3rd Qu.:2 #, Max. :1 Max. :2 Max. :2 #, #, Cumulative_Coverage_Ratio Identifier ID #, Min. :1 1fw :1 1-1,18*01,1:25,_fw:1 #, 1st Qu.:1 2fw :0 1-1,18*01,2:26,_fw:0 #, Median :1 3fw :0 1-1,18*01,3:27,_fw:0 #, Mean :1 4fw :0 1-1,18*01,4:28,_fw:0 #, 3rd Qu.:1 5fw :0 1-1,18*01,5:29,_fw:0 #, Max. :1 6fw :0 1-1,18*01,6:30,_fw:0 #, (Other):0 (Other) :0 #, Forward Reverse primer_length_fw primer_length_rev #, Length:1 Length:1 Min. :25 Min. :0 #, Class :character Class :character 1st Qu.:25 1st Qu.:0 #, Mode :character Mode :character Median :25 Median :0 #, Mean :25 Mean :0 #, 3rd Qu.:25 3rd Qu.:0 #, Max. :25 Max. :0 #, #, Direction Degeneracy_fw Degeneracy_rev Run #, Length:1 Min. :1 Min. :1 Length:1 #, Class :character 1st Qu.:1 ...
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Research into quercetin,a plant flavonoid with potent antioxidant action, has observed numerous health benefits, lets take a look at the top six!
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Dans notre petite encyclopédie des produits du Québec, nous lavons bien dit comment cuire ses têtes de violon fraîche. La Vie Rurale nous rappelle cependant ce quil convient de faire pour éviter toute intoxication. En attendant, on peut toujours consommé des produits déjà préparés ! A commander sur TerroirsQuébec : T
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Effect of chrysin on MAPKs protein expressions following isoproterenol-induced myocardial injury. (a) ERK½ and P-ERK½; (b) JNK and P-JNK; (c) p38 and P-p38 an
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Les médicaments antidiabétiques sont des médicaments qui peuvent êtres prescrits à la personne diabétique de type 2 ou prédiabétique lorsquun changement dhabitudes de vie ne permet pas de maintenir des glycémies[a1] près des val
T. megapotamicum contains luteolin. It also appears that many of the species contain a very similar chromatographic profile, ...
It is the luteolin-6-C-glucoside. Bioassay-directed fractionation techniques led to isolation of isoorientin as the main ... Isoorientin 3'-O-methyltransferase Orientin, the 8-C glucoside of luteolin. Hypoglycaemic activity of Gentiana olivieri and ...
... and luteolin; and coumarin. German chamomile is used in herbal medicine for a sore stomach, skin care, irritable bowel syndrome ...
DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
It is the 8-C glucoside of luteolin. Orientin is found in Adonis vernalis, in Anadenanthera colubrina and Anadenanthera ... Its identification using mass spectrometry is established Isoorientin (or homoorientin) is the luteolin-6-C-glucoside. ...
Gutiérrez-Venegas, Gloria; Kawasaki-Cárdenas, Perla; Rita Arroyo-Cruz, Santa; Maldonado-Frías, Silvia (2006-07-10). "Luteolin ...
It is a 7-O-glucoside of luteolin. It can be found in Ferula varia and F. foetida in Campanula persicifolia and C. rotundifolia ... Teslov, L. S.; Teslov, S. V. (1972). "Cynaroside and luteolin from Campanula persicifolia and C. Rotundifolia". Chemistry of ... Flavone 7-O-beta-glucosyltransferase adds a glucose to luteolin. A cynaroside 7-O-glucosidase has been identified in the ...
It is the 7-O-neohesperidoside of luteolin. It can be found in Veronicastrum sibiricum var. japonicum and in Teucrium ... japonicum Hara und Synthese des Luteolin-7-neohesperidosids (Veronicastrosid)". Chemische Berichte (in German). 102 (9): 3009- ...
Luteolin reduces IL-6 production in some neurons. Jones SA, Scheller J, Rose-John S (2011). "Therapeutic strategies for the ... Jang S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and ...
... contains the bioactive agents apigenin and luteolin. The total antioxidant capacity of artichoke flower heads is one ...
japonicum Hara und Synthese des Luteolin-7-neohesperidosids (Veronicastrosid). Hiroyuki Inouye, Yasuhiko Aoki, Hildebert Wagner ...
... luteolin-7-O-glucoside, luteolin-7-О-glucuronide, orientin, isoorientin, phenylpropanoids acteoside (verbascoside), ... Glyzin, V. I.; Peshkova, V. A.; Khokhrina, T. A. (November 1972). "Luteolin 7-β-D-glucosiduronic acid from Phlomis tuberosa". ... Phytochemical analyses of Phlomoides tuberosa leaves have found flavonoids apigenin, apigenin-7-O-glucuronide, luteolin, ... The roots shown the presence of oligosaccharides raffinose, stachyose, verbascose, flavonoids luteolin, linarin, quercitrin, ...
Various species contain apigenin, luteolin, quercetin, other flavonoids and ecdysteroids. Species Serratula alata Desf. ...
Flavonoids found in Scorzonera include apigenin, kaempferol, luteolin, and quercetin. Other secondary metabolites reported from ...
Luteolin - anti-mutagenic, anti-tumor, anti-oxidant, and anti-inflammatory. Quercetin - 3-O-β-D-galactoside is common in plants ...
... is a flavone, chemically the 3'-methoxy derivative of luteolin. Diosmetin is one of three possible regioisomers of ...
Her group discovered that a flavone (luteolin) derived from alfalfa seed extracts is necessary for activation of nodulation ... Peters, NK; Frost, JW; Long, SR (29 August 1986). "A plant flavone, luteolin, induces expression of Rhizobium meliloti ... Peters, NK; Frost, JW; Long, SR (29 August 1986). "A plant flavone, luteolin, induces expression of Rhizobium meliloti ...
Zhao G, Qin GW, Wang J, Chu WJ, Guo LH (2010). "Functional activation of monoamine transporters by luteolin and apigenin ... 2010). "Discovery and synthesis of novel luteolin derivatives as DAT agonists". Bioorg. Med. Chem. 18 (22): 7842-8. doi:10.1016 ...
Hartwig UA, Maxwell CA, Joseph CM, Phillips DA (January 1990). "Chrysoeriol and Luteolin Released from Alfalfa Seeds Induce nod ... Peters NK, Frost JW, Long SR (August 1986). "A plant flavone, luteolin, induces expression of Rhizobium meliloti nodulation ... luteolin, 3′,5-dimethoxyluteolin, 5-methoxyluteolin, medicarpin, stachydrine, and trigonelline. These compounds attract S. ...
Heartsease contains flavonoids (such as quercetin, luteolin and rutin), colorless crystalline compounds proven to be useful in ... Plants contain aglycones: apigenin, chrysoeriol, isorhamnetin, kaempferol, luteolin, quercetin and rutin. The fresh plant Viola ...
Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Drotaverine, used to alleviate renal colic ... Yu MC, Chen JH, Lai CY, Han CY, Ko WC (2009). "Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, ...
Yu, M. C.; Chen, J. H.; Lai, C. Y.; Han, C. Y.; Ko, W. C. (2009). "Luteolin, a non-selective competitive inhibitor of ... Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Mesembrenone, an alkaloid from the herb ...
Luteolin beets, artichokes, celery, carrots, celeriac, rutabaga, parsley, mint, chamomile, lemongrass, chrysanthemum. Flavan-3- ...
An, Sang Mi; Kim, Hyo Jung; Kim, Jung-Eun; Boo, Yong Chool (2008). "Flavonoids, taxifolin and luteolin attenuate cellular ...
Other compounds identified in the fruit include the polyphenols, luteolin, and kaempferol. In late 2012, a United States ...
Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance. Luteolin is the principal yellow dye compound ... Tambor synthesized luteolin. Luteolin is most often found in leaves, but it is also seen in rinds, barks, clover blossom, and ... Luteolin was first isolated in pure form, and named, in 1829 by the French chemist Michel Eugène Chevreul. The luteolin ... "Intestinal absorption of luteolin and luteolin 7-O-[beta]-glucoside in rats and humans". FEBS Letters. 438 (3): 220-4. doi: ...
Other names in common use include o-dihydric phenol methyltransferase, luteolin methyltransferase, luteolin 3-O- ... In enzymology, a luteolin O-methyltransferase (EC 2.1.1.42) is an enzyme that catalyzes the chemical reaction S-adenosyl-L- ... luteolin), whereas its two products are S-adenosylhomocysteine and 5,7,4-trihydroxy-3-methoxyflavone. This enzyme belongs to ...
... Lei Tang,1 Bin Deng,1 Lijuan Shi,2 Binghua ... Furthermore, we explored the influence of Luteolin on gene and protein expressions of 11β-HSD I/II in rat liver and kidney ... In this paper, we chose Luteolin which is one of the main ingredients of EP and evaluated its effect and metabolism in ... Our results showed that oral administration of Luteolin significantly increased the gene and protein expressions of hepatic 11β ...
1, 2: control group; 3, 4: Luteolin 5 mg/kg; 5, 6: Luteolin 10 mg/kg; 7, 8: Luteolin 20 mg/kg. ... Effects of Luteolin on Enzyme Activity of 11β-HSD I and 11β-HSD II in Rat Liver and Kidney. Effects of Luteolin on enzyme ... The effects of Luteolin on rat liver/kidney 11β-HSD indicated that Luteolin could affect the metabolism of prednisone/ ... The content of Luteolin in EP was 0.45 mg/g, determined by HPLC. The content of Luteolin was significantly higher than the ...
Luteolin is a flavonoid characterized by its yellow-green color. It is primarily produced among plants for their pigmentation ... Medicinal uses for luteolin. There is a wealth of evidence that prove the efficacy of luteolin in cancer growth interference. ... Body systems supported by luteolin. Luteolin keeps your entire body working at its most optimum state. By reducing the damage ... Luteolin is one of the few flavonoids that is not readily absorbed by the body. As such, it may - when taken incorrectly - ...
Luteolin is a bioactive flavonoid, isolated and characterized from the leaves of Vitex negundo. Lenses were extracted from ... Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo.. Rooban BN1, ... Luteolin treatment abated selenite induced oxidative stress and cataractogenesis by maintaining antioxidant status, reducing ... The antioxidant potential of luteolin was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. In the ...
In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. Ts65Dn mice, which are frequently used ... as a model of Down syndrome, were intraperitoneally injected with 10 mg/kg luteolin for 4 … ... Studies have shown that the natural flavonoid luteolin has neurotrophic activity. ... Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome Neural Regen Res. 2019 Apr;14(4):613-620. ...
The effects of luteolin and chloroquine on expression of cleaved-caspase 3 and LC3 in RPMI8826 cells was detected by Western ... METHODS: The effect of Luteolin on the growth of human multiple myeloma cell line RPMI-8226 was detected by CCK-8, and then the ... CONCLUSION: Luteolin inhibits the proliferation of RPMI-8226 cells by inducing the pathways of both apoptosis and autophagy, ... RESULTS: The luteolin significant inhibited RPMI-8226 cell proliferation in a dose-dependent manner. Treatment with lutedin 40- ...
Luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in ... To determine how luteolin inhibited IL-6 production in microglia, EMSAs were performed to establish the effects of luteolin on ... To determine whether luteolin might have similar effects in vivo, mice were provided drinking water supplemented with luteolin ... Luteolin consumption reduced LPS-induced IL-6 in plasma 4 h after injection. Furthermore, luteolin decreased the induction of ...
Luteolin has been reported earlier to be neuroprotective in models of spinal cord injury and traumatic brain injury and also ... Further, in a developing zebrafish model, luteolin treatment led to fewer numbers of mitotic cells in the brain. These specific ... However, the effect of luteolin on early differentiation, which might be important for its beneficial effects, is unknown. In ... These results show that luteolin perturbs neuronal differentiation of embryonic stem cells.KEYWORDS:Flavonoid, embryonic stem ...
Select 2018 high quality Wholesale Plant Extract Luteolin products in best price from certified Chinese Herb Extract ... Luteolin Powder Suppliers 98% Luteolin Supplements (491-70-3) Luteolin FOB Price: US $ 332-360 / kg. Min. Order: 25 kg ... Luteolin 98% Peanut Shell Extract Powder, Luteolin Peanut Powder FOB Price: US $ 5-25 / Kg. Min. Order: 1 Kg ... High Quality Luteolin Powder Peanut Shell Extract OEM Service FOB Price: US $ 10-455 / kg. Min. Order: 1 kg ...
2014). Luteolin protects against high fat diet-induced cognitive deficits in obesity mice. Behav. Brain Res. 267, 178-188. doi ... 2007). Effects of luteolin on learning acquisition in rats: involvement of the central cholinergic system. Life Sci. 80, 1692- ... Luteolin improved spatial memory in a scopolamine-induced model (Yoo et al., 2013) and in amyloid β-peptide-induced toxicity ( ... Luteolin was also shown to induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes (Xu et al., ...
Luteolin exhibited antiproliferative activity against LLC cells with IC50 of 12 microM. Luteolin effectively increased Annexin- ... mitochondrial membrane potential was reduced by luteolin as seen on fluorescence microscopy. Luteolin downregulated the ... In addition, luteolin significantly inhibited the growth of LLC cells implanted on the flank of mice to 40% and 60% of ... Luteolin was isolated from Scutellaria barbata D. Don (S. barbata). In the present study, we examined the underlying molecular ...
Flavones, luteolin and luteolin-7-O-glucoside along with a rich... ... Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion (Taraxacum ... Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. ... In this current study, luteolin and luteolin-7-O-glucoside at concentrations lower than 20 μM, significantly (p , 0.05) ...
Luteolin Explained. Leave a Comment WHAT IS LUTEOLIN? Luteolin is one of the many flavones that can be found in plant based ... In this article I will be discussing luteolin in greater detail. WHEN WAS LUTEOLIN DISCOVERED? Luteolin was discovered in 1938 ... Luteolin. - Tangeretin. The flavones are mainly found in green herbs and green leafy vegetables with artichokes, celery hearts ... Filed Under: Featured, Flavones Tagged With: antioxidants, apigenin, flavones, flavonoids, luteolin, phenolic compounds, ...
The flavonoid luteolin helped reduce inflammation in the brains of aged mice which restored memory to levels observed in ... Luteolin is found in carrots, rosemary, celery and other foods. The studys findings could have applications for treating ... "This demonstrated that luteolin isnt protecting the neurons directly," Dr Johnson stated. "Its doing it by affecting the ... "When we provided the old mice luteolin in the diet it reduced inflammation in the brain and at the same time restored working ...
Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett 438:220-224PubMedCrossRefGoogle ... Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. J Agric ... López-Lázaro M (2009) Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 9:31-59PubMedCrossRef ... Li L-P, Jiang H-D, Wu H, Zeng S (2005) Simultaneous determination of luteolin and apigenin in dog plamsa by RP-HPLC. J Pharm ...
Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats.. [Xiaobin Fu, ... However, long-term administration of luteolin significantly down-regulated the expression of NF-κB and BACE1, accompanied by ... Our results suggest a potential therapeutic use of luteolin for cerebral hypoperfusion associated cognitive dysfunction in AD. ... As expected, we found that luteolin could attenuate cognitive dysfunction in chronic cerebral hypoperfused rats, as assessed ...
2019 Apr 24;: Authors: Yao Y, Rao C, Zheng G, Wang S Abstract Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid ... In the present study, the role of luteolin and its unde... ... Luteolin was found to upregulate miR‑384 and downregulate PTN ... Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis. Oncol Rep. ... Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR ‑384/pleiotrophin axis.. *. ...
Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-α production, ... Keywords: Perilla frutescens, luteolin, anti-inflammation, anti-allergy, tumor necrosis factor-α ... Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens ... These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla. ...
Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects ... Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p.. [Chen Bian, ...
Luteolin is one of the major components of celery and green peppers, its inhibitory activity on XO and their i … ... Effect of Luteolin on Xanthine Oxidase: Inhibition Kinetics and Interaction Mechanism Merging With Docking Simulation Food Chem ... Luteolin is one of the major components of celery and green peppers, its inhibitory activity on XO and their interaction ... It was found that luteolin reversibly inhibited XO in a competitive manner with inhibition constant (Ki) value of (2.38±0.05)× ...
Adult and aged mice were provided control or luteolin supplemented diet for four weeks. Dietary supplementation of luteolin ... Finally, given these potent anti-inflammatory properties of luteolin, as well as the inverse relationship between flavonoid ... Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell ... Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation. Welcome to the IDEALS Repository. ...
... luteolin (LE), chlorogenic acid (CA) and apigenin (AP) are four major flavonoids with various promising bioactivities found in ... Keywords: UPLC; linarin; luteolin; chlorogenic; apigenin; Compositae UPLC; linarin; luteolin; chlorogenic; apigenin; Compositae ... Linarin (LA), luteolin (LE), chlorogenic acid (CA) and apigenin (AP) are four major flavonoids with various promising ... Simultaneous Ultra Performance Liquid Chromatography Determination and Antioxidant Activity of Linarin, Luteolin, Chlorogenic ...
... were decreased by treatment of the cells with luteolin. Luteolin inhibited PMA plus A23187-induced nuclear factor (NF)-κB ... Furthermore, luteolin suppressed the expression of TNF-α, IL-8, IL-6, GM-CSF, and COX-2 through a decrease in the intracellular ... Luteolin significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL ... Moreover, luteolin attenuated cyclooxygenase (COX)-2 expression and intracellular Ca2+ levels. In activated HMC-1 cells, the ...
Anti-bacterial Peanut Shell Extract Luteolin 98%,Luteolin,Peanut Shelll Extract Powder,Luteolin Powder from Other Extracts ... Anti-bacterial Peanut Shell Extract Luteolin 98% , Find Complete Details about Anti-tumor& ... Application of Luteolin Powder:. 1.Luteolin applied in food field, Luteolin is often used as food additives.. 2.Luteolin ... Function of Luteolin Powder:. 1.Luteolin has the function of anti-inflammatory, anti-microbial and anti-virus.. 2.Luteolin has ...
... luteolin) is a natural flavonoids, found in many plants. With various pharmacological activities, such as anti-inflammatory, ...
All-Union Scientific-Research Institute of Medicinal Plants. Tuymen Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 802-803, November-December, 1972. ...
Apigenin and luteolin were identified in our U-2 OS (human osteosarcoma) cell screening assay for micronutrients triggering ... PKB/AKT-, PRAS40-, p70S6K-, and S6-phosphorylation was reduced by apigenin and luteolin but not that of the insulin-like growth ... N-acetyl-L-cysteine did not prevent FOXO1 nuclear translocation induced by apigenin and luteolin, suggesting that these ... and luteolin (3′,4′,5,7,-tetrahydroxyflavone) are plant secondary metabolites with antioxidant, antiinflammatory, and ...
Raffoul on how can luteolin cure kidney failure: Depends on what they are made of. Uric acid stone are one type others are made ... Good luck for topic: How Can Luteolin Cure Kidney Failure ... Doctor insights on: How Can Luteolin Cure Kidney Failure Share ...
  • although this does not in any way suggest that luteolin does not offer any health benefits. (naturalpedia.com)
  • Taken together, these results suggest that luteolin exerts antitumor activity by caspase activation and ERK/Akt inhibition. (nih.gov)
  • These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla. (go.jp)
  • Our results suggest that luteolin could be a potent anti-angiogenic agent for retinal neovascularization, which is related to anti-oxidative activity to block ROS production and to subsequently suppress VEGF expression and the pro-angiogenic effect of VEGF. (arvojournals.org)
  • This suggest that luteolin can be used in the prevention and treatment of cardiovascular diseases . (selfhacked.com)
  • The present findings suggest that luteolin ameliorates D-GalN/LPS-induced liver injury and that this protection is likely due to inhibition of the extrinsic and intrinsic apoptotic pathways. (sparrho.com)
  • These results suggest that luteolin may be a regulatory molecule that facilitates the differentiation of osteoblasts . (bvsalud.org)
  • In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. (nih.gov)
  • Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats. (sigmaaldrich.com)
  • In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. (medworm.com)
  • The role of luteolin in colorectal cancer (CRC) has also been investigated. (spandidos-publications.com)
  • The objective of present study is to divulge the chemopreventive role of luteolin against benzo(a)pyrene [B(a)P] induced lung carcinogenesis in Swiss albino mice. (esmo.org)
  • Luteolin inhibits the proliferation of RPMI-8226 cells by inducing the pathways of both apoptosis and autophagy, moreover the actions of apoptosis and autophagy are interactive or/and promotive each other. (greenmedinfo.com)
  • Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. (nih.gov)
  • Luteolin has been found to inhibit CRC cells proliferation, induce cells apoptosis and cell cycle perturbation ( 13 - 15 ). (spandidos-publications.com)
  • In prostate cancer cells, luteolin treatment inhibited prostate cancer cells proliferation and induced apoptosis through downregulation of miR-301 by triggering DEDD2 expression ( 25 ). (spandidos-publications.com)
  • Luteolin also inhibited the tumorigenesis and induced the apoptosis of non-small cell lung cancer cells by upregulation of miR-34a-5p by targeting MDM4 ( 26 ). (spandidos-publications.com)
  • With the deepening of the study on luteolin, researchers have found that it have anti-cancer activities including inhibiting the proliferation of tumor cell, inducing the apoptosis of tumor cells as well as sensitizing anti-cancer drugs. (chemicalbook.com)
  • Preliminary studies have found that luteolin can inhibit the apoptosis of the angiogenesis induced cell, affect the tumor growth in animal models, reduce the tumor growth and also improve the cytotoxicity of certain anti-cancer drugs on the tumor cell, indicating that luteolin could be potential cancer chemo-preventive drugs and chemotherapy drugs. (chemicalbook.com)
  • Luteolin effectively inhibited cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. (aacrjournals.org)
  • To test this hypothesis, we showed that the combined use of luteolin and mTOR inhibitor rapamycin prevented low doses of luteolin from inducing p21 expression, and HER2-overexpressing cancer cells would be sensitized toward luteolin-induced apoptosis. (aacrjournals.org)
  • Apoptotic assays revealed that the multi-heavy metal mixture induced HL7702 cell apoptosis in a dose-dependent manner, which was significantly inhibited by 20 µM luteolin. (spandidos-publications.com)
  • The present results suggested luteolin exerts its inhibitory effects of on multi-heavy metal mixture induced cell apoptosis through downregulation of the ROS-activated mitochondrial pathway. (spandidos-publications.com)
  • Luteolin and lapatinib synergistically induced the apoptosis of BT474 cells. (alliedacademies.org)
  • The present study demonstrates that synergistic use of luteolin with lapatinib inhibits the growth of breast cancer cells, possibly by inducing apoptosis via the deactivation of AKT and ERK signaling pathways. (alliedacademies.org)
  • Next we studied the underlying mechanism of luteolin action, and found its inducing apoptosis of HepG2 cell, apoptosis was monitored based on propidium iodide internalization assay using flow cytometer (FACS). (alliedacademies.org)
  • Altogether our result clearly showed the details mechanistic pathway by which luteolin is inducing apoptosis in HepG2. (alliedacademies.org)
  • The biochemical events related to apoptosis such as DNA ladder formation and caspase-3 activation were also enhanced by luteolin. (jfda-online.com)
  • In another study, researchers found that pre-treatment with luteolin greatly sensitised TNF alpha-induced apoptosis in a number of human cell lines, including cancers of the colon and cervix. (supersmart.com)
  • Furthermore, luteolin treatment significantly reduced renal cell apoptosis and endoplasmic reticulum (ER) stress caused by renal I/R injury. (iitkgp.ac.in)
  • In conclusion, luteolin improved renal function in I/R rats by reducing oxidative stress, neutrophil infiltration, inflammation, renal cell apoptosis, and expression of HMGB1 and NF-κB, and ER stress. (iitkgp.ac.in)
  • Luteolin was shown to trigger apoptosis (programmed cell death) by arresting the normal cell cycle that typically results in uncontrolled growth. (blogspot.com)
  • Luteolin is one of the few flavonoids that is not readily absorbed by the body. (naturalpedia.com)
  • We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors. (springer.com)
  • Luteolin, a polyphenolic compound found in foods of plant origin, belonging to the flavone subclass of flavonoids, has been shown to possess antioxidant, anti-inflammatory and antitumorigenic properties. (sigmaaldrich.com)
  • Linarin (LA), luteolin (LE), chlorogenic acid (CA) and apigenin (AP) are four major flavonoids with various promising bioactivities found in Compositae (COP) species. (mdpi.com)
  • Luteolin is a very typical kind of natural flavonoid and belongs to weak acidic tetrahydroxy flavonoids. (chemicalbook.com)
  • Luteolin shown in Figure 1 is one of the important dietary flavonoids which are commonly present in various fruits and vegetables. (alliedacademies.org)
  • RP-HPLC-DAD detrmination of flavonoids: separation of quercetin, luteolin and apigenin in Marchantia Convoluta', Iranian Journal of Pharmaceutical Research , Volume 4(Number 3), pp. 175-181. (ac.ir)
  • Chen, X., Xiao, J. RP-HPLC-DAD detrmination of flavonoids: separation of quercetin, luteolin and apigenin in Marchantia Convoluta. (ac.ir)
  • The HPLC method showed an excellent performance in separating the flavonoids quercetin, luteolin and apigenin in Marchantia convoluta extracts, since the presence of interference has been previously evaluated and the mobile phase was chose carefully. (ac.ir)
  • Certain flavonoids, such as luteolin, have anti-oxidant and anti-inflammatory effects, including inhibition of activated peripheral blood leukocytes from MS patients. (longevityunlocked.com)
  • Moreover, luteolin and structurally similar flavonoids can inhibit experimental allergic allergic encephalomyelitis (EAE). (longevityunlocked.com)
  • Flavonoids such as Quercetin and Luteolin have potent anti-oxidant and anti-inflammatory activity. (longevityunlocked.com)
  • Luteolin (3',4',5,7-tetrahydroxyflavone) forms part of the large family of flavonoids which includes at least 4,000 different compounds. (supersmart.com)
  • Some studies have shown luteolin to be twice as effective at counteracting oxidative damage to DNA (using the Trolox test) as vitamins C and E and seven other flavonoids. (supersmart.com)
  • In vitro studies also show that certain flavonoids found in artichoke leaf, particularly luteolin, prevent oxidation of LDL-cholesterol and may therefore reduce the risk of atherosclerosis. (supersmart.com)
  • ANTIOXIDANT: Luteolin has been shown to be more effective than Vitamin C & E, and seven other flavonoids in reducing DNA oxidative damage. (healthcarebd.com)
  • Luteolin has been proven to be simpler than Diet C & E, and 7 different flavonoids in lowering DNA oxidative harm. (healthcarebd.com)
  • Luteolin, a flavonoid found in high concentrations in celery and green pepper, has been shown to reduce production of proinflammatory mediators in LPS-stimulated macrophages, fibroblasts, and intestinal epithelial cells. (greenmedinfo.com)
  • Luteolin (luteolin) is a natural flavonoid found in many plants. (alibaba.com)
  • Luteolin is a flavonoid found in many types of plants including fruits, vegetables, and medicinal herbs. (selfhacked.com)
  • The antioxidant potential of luteolin was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. (nih.gov)
  • Luteolin treatment abated selenite induced oxidative stress and cataractogenesis by maintaining antioxidant status, reducing ROS generation and lipid peroxidation in the lens. (nih.gov)
  • These finding demonstrated the anticataractogenic effect of luteolin by virtue of its antioxidant property, which has been reported in this paper for the first time. (nih.gov)
  • Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion ( Taraxacum officinale ) flower extract were studied for antioxidant activity in different in vitro model systems. (springer.com)
  • Daily oral administration of luteolin (50, 100 and 200mg/kg) significantly scavenged oxygen free radicals, enhanced antioxidant potential, decreased the lipid peroxide production and suppressed inflammatory reaction in the cerebral cortex and hippocampus induced by chronic cerebral hypoperfusion. (sigmaaldrich.com)
  • Luteolin significantly induces genes related to antioxidant defense. (selfhacked.com)
  • Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically. (longevityunlocked.com)
  • There has been a great deal of research into the various affects of Luteolin, common uses include its use as an antioxidant, plus the promotion of carbohydrate metabolism, modulation of the immune system and the treatment of type 2 diabetes. (lowtestosteroneexpert.com)
  • Luteolin is a potent bioflavonoid with antioxidant and anti-inflammatory properties. (youngnutra.com)
  • Is Antioxidant Luteolin an Anticancer Super-nutrient? (city-connect.org)
  • Luteolin has great anti-inflammatory and antioxidant effects. (iitkgp.ac.in)
  • Luteolin is one of a number of natural plant-derived compounds that are known to exhibit powerful anti-inflammatory, antioxidant and anti-cancer properties. (blogspot.com)
  • Consistent with this finding, luteolin did not inhibit LPS-induced degradation of IkappaB-alpha but inhibited JNK phosphorylation. (greenmedinfo.com)
  • Liu et al also reported that luteolin was able to inhibit CRC cells epithelial to mesenchymal transition by suppressing CREB1 expression ( 16 ). (spandidos-publications.com)
  • It was reported that luteolin, extracted from Chinese herbs, could potently inhibit influenza virus replication in vitro. (springermedizin.de)
  • In this paper, we predict and analyze the ability of luteolin to inhibit TNF-α and NF-κB pathways including TNFR1, TRADD, TRAF2, RIP1, and IKKβ. (eurekaselect.com)
  • Luteolin can also inhibit colitis (inflammation in the colon). (selfhacked.com)
  • In an experiment on rats, luteolin was found to inhibit cell death in the cells of the heart. (selfhacked.com)
  • Innovative ways of delivering select flavonoid combinations would be required to assure sufficient plasma levels, especially if luteolin can inhibit brain inflammation. (longevityunlocked.com)
  • New research published in BioMed Central's open access journal BMC Gastroenterology shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells. (nutritioninsight.com)
  • The result of a body of research published in the journal BMC Gastroenterology has found that consumption of the plant flavonoid, luteolin is able to inhibit the activity of cell signaling pathways (known as IGF and PI3K) important for the growth of colon cancer. (blogspot.com)
  • The flavone luteolin has numerous useful actions that include: anti-oxidant, anti-inflammatory, microglia inhibition, neuroprotection, and memory increase. (frontiersin.org)
  • miR‑384 inhibition and PTN overexpression partially reversed the inhibition of HT‑29 cells migration and invasion induced by luteolin. (medworm.com)
  • Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-α production, inhibition of arachidonic acid-induced ear edema, inhibition of 12- O -tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. (go.jp)
  • It was found that luteolin reversibly inhibited XO in a competitive manner with inhibition constant (Ki) value of (2.38±0.05)×10(-6) mol l(-1). (nih.gov)
  • Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained Akt/mTOR inhibition may contribute to p21 induction and provide a survival advantage to HER2-overexpressing cancer cells. (aacrjournals.org)
  • In nude mice with xenografted SKOV3.ip1-induced tumors, luteolin significantly inhibited HER2 expression and tumor growth in a dose-dependent manner, and rapamycin further enhanced the effect of luteolin with a concomitant p21 inhibition. (aacrjournals.org)
  • The present study is to investigate the synergistic effect of lapatinib and luteolin in the inhibition of the growth and proliferation of breast cancer cells, as well as the underlying mechanisms. (alliedacademies.org)
  • Introduction: Luteolin, a natural flavonoid is known to possess variety of pharmacological activity, particularly growth inhibition. (elsevier.com)
  • Concurrently, luteolin possesses potent estrogen agonist activity while quercetin is considerably less effective. (springer.com)
  • Finally, given these potent anti-inflammatory properties of luteolin, as well as the inverse relationship between flavonoid intake and cognitive decline in older persons and aged animals reported by others, we explored whether dietary supplementation of luteolin can ameliorate age-related deficits in spatial working memory and reduce inflammatory molecules in aged brain. (illinois.edu)
  • In this study, we showed that luteolin, a naturally occurring flavonoid, is a potent stimulator of HER2 degradation. (aacrjournals.org)
  • Luteolin also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. (semanticscholar.org)
  • Luteolin was found to have potent antiviral activity against Japanese encephalitis virus (JEV). (selfhacked.com)
  • Luteolin is a potent hypoglycemic agent and improves insulins sensitivity. (made-in-china.com)
  • Administration of B(a)P to mice resulted in increased lipid peroxides (LPO) with concomitant decrease in the levels of both enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), and non-enzymatic antioxidants such as reduced glutathione (GSH), vitamin E and vitamin C. Luteolin supplementation (15 mg/kg body weight) significantly attenuated these alterations thereby showing potent anticancer effect in lung cancer. (esmo.org)
  • Authors: Yao Y, Rao C, Zheng G, Wang S Abstract Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. (medworm.com)
  • The effects of different concentrations of Luteolin extract on prednisone/prednisolone metabolism indicated the enzyme activity of 11 β -HSD, so the production rate (pmol/min per mg protein) of metabolites was used to indicate enzyme activity. (hindawi.com)
  • A liposomal luteolin formulation in olive fruit extract improved attention in children with ASDs and brain "fog" in mastocytosis patients. (frontiersin.org)
  • Similar suppression for both inducible enzymes was also found with the presence of dandelion flower extract, specifically, the ethyl acetate fraction of dandelion flower extract which contained 10% luteolin and luteolin-7-O-glucoside. (springer.com)
  • Product Name: peanut shell extract luteolin 98% Latin Name: Arachis hypogaea L. (trader-china.com)
  • Our company is specialized exporter, manufacturer and supplier of Pure Natural Peanut Shell Extract 98% Luteolin Powder in 中国. (trader-china.com)
  • Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). (nii.ac.jp)
  • HPLC results of luteolin content in various extracts using luteolin as the marker compound indicated the ethanol extract to contain the highest concentration of luteolin (0.372% w/w). (biomedcentral.com)
  • The aqueous extract contained lower concentration of luteolin (0.282% w/w). (biomedcentral.com)
  • Artichoke Extract (Luteolin) has been shown to boost memory and learning, improve motivation and mood, and stimulate the growth of new neurons in the brain. (nootropicsexpert.com)
  • Artichoke Extract (Luteolin) is a natural PDE4 inhibitor in the brain. (nootropicsexpert.com)
  • Artichoke Extract contains a naturally occurring compound called luteolin . (nootropicsexpert.com)
  • Artichoke Extract (Luteolin) vs. Pure Luteolin: What's the Difference? (nootropicsexpert.com)
  • Luteolin, Herb Extracts, Bioflavonel manufacturer / supplier in China, offering 100% Natural High Quality Luteolin 98%, Pure Natural Mucuna Extract L-Dopa Levodopa, Traditional Herbology Memory Enhancer Huperzine a and so on. (made-in-china.com)
  • FibroProtek - All natural, dietary supplement in softgel form Exclusive combination of Coenzyme Q10, Carnitine, Luteolin, Quercetin, White Willow Extract, & Olive Oil Research has shown the ingredients in FibroProtek¨ may promote neuromuscular harmony. (vitaminsstore.net)
  • Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. (spandidos-publications.com)
  • The promising anticancer potential of luteolin can be effectively utilized in future for anticancer drug development. (alliedacademies.org)
  • Long term treatment did not show any apparent toxicity in rats at a dose of 30mg/kg, implying that luteolin is relatively safe as an anticancer agent. (selfhacked.com)
  • Observations propose that luteolin could be an anticancer agent for various cancers. (longevityunlocked.com)
  • A flavonoid compound found in fruit and vegetables, luteolin, was recently hailed as an anticancer supernutrient by the tabloid media. (city-connect.org)
  • The lab study is an essential first step to understanding whether luteolin or more likely a chemical cousin might eventually be developed as an anticancer drug, although this is preliminary, fundamental molecular biology not clinical testing and animal studies for initial testing of such a compound are still a long way off. (city-connect.org)
  • Further, the anticancer effect of luteolin was confirmed by histopathological and immunoblotting analysis of CYP1A1, NF-κB and Nrf2, where luteolin supplementation modulated the expression of these proteins and maintained cellular homeostasis. (esmo.org)
  • Luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia and may be useful for mitigating neuroinflammation. (greenmedinfo.com)
  • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. (greenmedinfo.com)
  • Because excessive production of proinflammatory cytokines by activated brain microglia can cause behavioral pathology and neurodegeneration, we sought to determine whether luteolin also regulates microglial cell production of a prototypic inflammatory cytokine, IL-6. (greenmedinfo.com)
  • To determine how luteolin inhibited IL-6 production in microglia, EMSAs were performed to establish the effects of luteolin on LPS-induced binding of transcription factors to the NF-kappaB and activator protein-1 (AP-1) sites on the IL-6 promoter. (greenmedinfo.com)
  • Taken together, these data suggest luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia. (greenmedinfo.com)
  • While pretreatment of neurons with luteolin showed no benefit, exposure of microglia to this compound prevented neuron death. (lifeextension.com)
  • Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and consequently, attenuating age-associated cognitive decline. (illinois.edu)
  • Luteolin suppressed pro-inflammatory marker expression and cytokine expression in LPS-activated microglia. (selfhacked.com)
  • The article offers information related to the research on the effect of luteolin in microglia. (encognitive.com)
  • Researchers studied the effect of Luteolin on immune system cells in the brain called microglia . (nootropicsexpert.com)
  • Animal sciences professor Rodney Johnson, and graduate student Saebyeol Jang found that a plant flavonoid, luteolin, inhibited a key pathway in the inflammatory response of microglia. (clinicalnews.org)
  • The researchers first studied the effect of luteolin on microglia. (clinicalnews.org)
  • Free radical mediated oxidative stress plays a crucial role in the pathogenesis of cataract and the present study was to determine the efficacy of luteolin in preventing selenite induced oxidative stress and cataractogenesis in vitro. (nih.gov)
  • It was demonstrated that luteolin had no effects on CRC cells proliferation while inhibited cells migration and invasion both in vitro and in vivo. (medworm.com)
  • Using the inhibitory activity of TNF-α production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. (go.jp)
  • Phytochylomicron as a dual nanocarrier for liver cancer targeting of luteolin: in vitro appraisal and pharmacodynamics. (semanticscholar.org)
  • Through in vitro and vivo experiments, luteolin was found to have therapeutic and preventative activities against cancer associated with estrogen . (selfhacked.com)
  • Luteolin potently inhibited UVB-induced MMP-1 expression and wrinkle formation in vitro and in vivo and therefore may be used for prevention of UVB-induced skin aging. (selfhacked.com)
  • NEUROPROTECTIVE: Luteolin possesses beneficial neuroprotective effects both in vitro and in vivo. (healthcarebd.com)
  • Luteolin possesses a good idea neuroprotective results each in vitro and in vivo. (healthcarebd.com)
  • There is a wealth of evidence that prove the efficacy of luteolin in cancer growth interference . (naturalpedia.com)
  • Overall, these findings confirm the chemopreventive potential of luteolin against B(a)P induced lung cancer in Swiss albino mice. (esmo.org)
  • In the present study, we examined the underlying molecular mechanism of luteolin and its effect on in vivo tumor growth of Lewis lung carcinoma (LLC) cells. (nih.gov)
  • To assess the effect and explore the fundamental mechanism of luteolin, we infected several cell lines with two subtypes of influenza A virus (IAV), including A/Jiangxi/312/2006 (H3N2) and A/Fort Monmouth/1/1947 (H1N1) and demonstrated that luteolin suppressed the replication of IAV by cytopathic effect reduction method, qRT-PCR, immunofluorescence and Western blot assays. (springermedizin.de)
  • Luteolin is the pigment that gives foods such as celery and parsley their lovely, green color. (naturalpedia.com)
  • Luteolin is found in carrots, rosemary, celery and other foods. (lifeextension.com)
  • Luteolin is one of the major components of celery and green peppers, its inhibitory activity on XO and their interaction mechanism were evaluated by multispectroscopic methods, coupled with molecular simulation. (nih.gov)
  • Luteolin is a common type of natural flavonoid that is abundant in the leaves of celery, green pepper and dandelion. (alliedacademies.org)
  • Green leaves such as parsley and celery top the list of luteolin-rich foods. (selfhacked.com)
  • As further studies are planned to better understand the impact of luteolin on colon cancer progression, most adults will want to ensure a regular intake by consuming plenty of vegetables including celery hearts, hot peppers, parsley or spinach or supplement with a full-spectrum multi-vitamin containing the flavonoid. (blogspot.com)
  • Luteolin is a flavonoid that exists in a glycosylated form in celery and green pepper . (bvsalud.org)
  • This work was designed, therefore, to develop an HPLC-DAD system to separate quercetin, luteolin and apigenin and to quantify them in extractive solutions from Marchantia convoluta. (ac.ir)
  • The HPLC system was operated at ambient temperature (28±1°C). The method showed linearity for quercetin, luteolin and apigenin in the range 2.0-20.8, 2.2-24.0 and 1.6-20.0 ?g/ml respectively, and the R.S.D. of the slope of the three lines was, respectively, 0.33%, 1.21% and 2.49% for quercetin, luteolin and apigenin. (ac.ir)
  • The recoveries were 95.92-98.10%, 92.18-95.13% and 98.72-103.19% for quercetin, luteolin and apigenin respectively. (ac.ir)
  • Luteolin is a natural anti-oxidant with not as much pro-oxidant (inducing oxidative stress ) potential than the most studied flavonoid quercetin, but apparently with a better safety profile. (longevityunlocked.com)
  • Quercetin and Luteolin are safe. (longevityunlocked.com)
  • Like quercetin or rutin, luteolin suppresses allergen-induced inflammatory response by inhibiting lipooxygenase. (supersmart.com)
  • NHS Choices emphasises that, "It is important to remember that this study used pure luteolin, and not dietary sources of the compound. (city-connect.org)
  • Product Name: Luteolin Botanical Source: The natural luteolin is extracted mainly from the shell of the peanut. (botanical-powder.com)
  • POTENCY: Luteolin 100 Supplies 100mg of ninety% Natural Luteolin in 1 Pills in step with Serving. (healthcarebd.com)
  • Mice studies have shown that luteolin was particularly efficient in reducing tumor growth in ovarian cancer cells. (naturalpedia.com)
  • Ts65Dn mice, which are frequently used as a model of Down syndrome, were intraperitoneally injected with 10 mg/kg luteolin for 4 consecutive weeks starting at 12 weeks of age. (nih.gov)
  • Our findings show that luteolin improves behavioral performance and promotes hippocampal neurogenesis in Ts65Dn mice. (nih.gov)
  • To determine whether luteolin might have similar effects in vivo, mice were provided drinking water supplemented with luteolin for 21 days and then they were injected i.p. with LPS. (greenmedinfo.com)
  • In addition, luteolin significantly inhibited the growth of LLC cells implanted on the flank of mice to 40% and 60% of untreated control group values at 2 mg/kg and 10 mg/kg, respectively. (nih.gov)
  • Similarly, luteolin significantly reduced the expression of proliferating cell nuclear antigen (PCNA) as well as increased the expression of terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) in tumor section of LLC-bearing mice as determined by immunohistochemistry. (nih.gov)
  • Rodney Johnson and his associates at the University of Illinois report in the October, 2010 issue of the Journal of Nutrition that the flavonoid luteolin helped reduce inflammation in the brains of aged mice, which restored memory to levels observed in younger animals. (lifeextension.com)
  • In an experiment with mice, adult and aged animals were fed a control diet or a luteolin-enhanced diet for four weeks. (lifeextension.com)
  • Assessment of spatial memory found increased learning and recall in older mice supplemented with luteolin compared to aged controls. (lifeextension.com)
  • When we provided the old mice luteolin in the diet it reduced inflammation in the brain and at the same time restored working memory to what was seen in young cohorts," Dr Johnson stated. (lifeextension.com)
  • Adult and aged mice were provided control or luteolin supplemented diet for four weeks. (illinois.edu)
  • Dietary supplementation of luteolin attenuated the age-related spatial working memory deficits along with alleviating hippocampal IL-1beta and major histocompatibility complex (MHC) class II mRNA expression in aged mice. (illinois.edu)
  • Researchers found that luteolin also reduced stem cell-like characteristics and blood vessel formation when tested in mice with breast cancer. (doctorshealthpress.com)
  • The toxicity of luteolin was evaluated through modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay in human retinal microvascular endothelial cells (HRMECs) as well as TUNEL staining in the retina of C57BL/6J mice. (arvojournals.org)
  • Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). (springermedizin.de)
  • In mice, luteolin suppressed growth of tumors formed from human skin carcinoma , hepatoma, and human ovarian cancer cells. (selfhacked.com)
  • Luteolin can go through the blood-brain-barrier (BBB), which shows anti-amnesic effects against the toxicity of amyloid in mice. (selfhacked.com)
  • Luteolin also protects against high-fat diet-induced cognitive defects in obesity mice. (selfhacked.com)
  • When scientists supplemented the diet of mice with luteolin, they noted a 40% decrease in rates of fibrosarcoma. (supersmart.com)
  • Protective effects of luteolin against apoptotic liver damage induced by D-galactosamine/lipopolysaccharide in mice. (sparrho.com)
  • Luteolin and luteolin-7- O -glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice. (sparrho.com)
  • To see if luteolin might have a similar effect in vivo, the researchers gave mice luteolin-laced drinking water for 21 days before injecting the mice with LPS. (clinicalnews.org)
  • Those mice that were fed luteolin had significantly lower levels of IL-6 in their blood plasma four hours after injection with the LPS. (clinicalnews.org)
  • An MTT assay demonstrated that 20 µM luteolin significantly alleviated the multi-heavy metal mixture-induced cell death and morphological changes. (spandidos-publications.com)
  • A JC-1 staining assay indicated that 20 µM luteolin inhibited the mitochondrial membrane potential-reducing effect of the multi-heavy metal mixture. (spandidos-publications.com)
  • Anti-angiogenic activity of luteolin was evaluated by VEGF-induced migration and tube formation assay. (arvojournals.org)
  • Next we measured ROS generation ability and lipid peroxidation effect induced by luteolin and measured using TBARS assay. (alliedacademies.org)
  • Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo. (nih.gov)
  • Luteolin substantially increased cell life while reducing evidence of oxidative stress-induced damage in the cells. (selfhacked.com)
  • Luteolin also improved the recovery of heart cells contracting function following simulated injury caused by loss of blood flow, by reducing oxidative stress . (selfhacked.com)
  • Luteolin is a natural supplement for fighting oxidative stress. (supersmart.com)
  • The neurons survived because the luteolin inhibited the production of neurotoxic inflammatory mediators. (lifeextension.com)
  • We believe dietary luteolin accesses the brain and inhibits or reduces activation of microglial cells and the inflammatory cytokines they produce. (lifeextension.com)
  • 1.Luteolin has the function of anti-inflammatory, anti-microbial and anti-virus. (alibaba.com)
  • Luteolin has been reported to display a wide range of bioactive properties, such as anti-virus ( 1 , 2 ), hepatoprotective ( 3 ), anti-inflammatory ( 4 ) and anti-diabetic effects ( 5 ). (spandidos-publications.com)
  • 4 Preclinical studies have shown that the pharmacological effects of luteolin might include anti-oxidant, anti-inflammatory, antibacterial and anti-cancer. (chemicalbook.com)
  • Chinese traditional medicine uses luteolin for treatment of hypertension, inflammatory diseases, and cancer. (eurekaselect.com)
  • In an experiment on rats with toxin-induced uveitis, luteolin had great success in anti-inflammatory treatment, comparable to that of prednisolone. (selfhacked.com)
  • Studies on rats with Alzheimer's Disease have confirmed the anti-inflammatory and brain-protecting effects of luteolin. (selfhacked.com)
  • Plants sources rich in luteolin have appeared in Chinese traditional medicine for treating many diseases such as hypertension, inflammatory disorders, and cancer. (longevityunlocked.com)
  • Basic research results indicate luteolin as an anti-inflammatory agent with other potential effects on septic shock. (longevityunlocked.com)
  • Luteolin is a natural substance in vegetarian capsules, extracted from groundnut with potential anti-ageing and anti-inflammatory benefits, now available to buy at Supersmart. (supersmart.com)
  • Luteolin-rich plants are used in traditional Chinese medicine to treat various disorders such as hypertension, inflammatory problems and cancer. (supersmart.com)
  • Certain studies have shown that luteolin can eliminate excessive inflammatory cytokines in the brain , such as interleukin 6 and interleukin 1b, by acting on microglial cells, thus maintaining cognitive function, particularly memory and learning. (supersmart.com)
  • When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant and neuroprotective properties. (youngnutra.com)
  • This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. (youngnutra.com)
  • Luteolin is a flavonoid contained in many workss and with a assortment of known pharmacological belongingss such as anti-inflammatory, anti-anxiety, and memory-improving effects, proposing that LUT penetrates into the encephalon. (yogurtlandsweettreats.com)
  • Those cells that were also exposed to luteolin showed a significantly diminished inflammatory response. (clinicalnews.org)
  • Jang showed that luteolin was shutting down production of a key cytokine in the inflammatory pathway, interleukin-6 (IL-6). (clinicalnews.org)
  • ANTI-INFLAMMATORY: Luteolin has been shown to reduce age-related memory deficits, may reduce the brain's production of inflammatory cytokines. (healthcarebd.com)
  • Luteolin has been proven to scale back age-comparable reminiscence deficits, would possibly cut back the mind's production of inflammatory cytokines. (healthcarebd.com)
  • Luteolin is one such naturally occurring dietary phytochemical possesses anti-oxidative, anti-inflammatory and anti-proliferative activity in a wide variety of cancer. (esmo.org)
  • Luteolin also induces cell death in cancer cells. (selfhacked.com)
  • Luteolin induces neurite outgrowth through CREB activation. (selfhacked.com)
  • Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR ‑384/pleiotrophin axis. (medworm.com)
  • Luteolin suppresses the growth of colorectal cancer by regulating Wnt/β-catenin/GSK-3β signaling pathway and activating Nrf2 signaling pathway [ 14 ], and enhances the effect of tamoxifen on breast cancer by inhibiting the expression of cyclin E2 [ 15 ]. (alliedacademies.org)
  • Experiments with animals show that luteolin suppresses bacteria-induced inflammation. (selfhacked.com)
  • An attempt was also made to estimate the luteolin content in different extracts of Anisochilus carnosus by HPLC (High Performance Liquid Chromatography). (biomedcentral.com)
  • We also detected the luteolin content in different extracts (ethanolic and aqueous) of A.carnosus by using HPLC as a tool of analysis. (biomedcentral.com)
  • Quantification of luteolin in various extracts was done through High Performance Liquid Chromatography (HPLC). (currentbioactivecompounds.com)
  • Thus our results demonstrate for the first time that luteolin, a dietary flavonoid, exerts chemopreventive and anticarcinogenic effects against DMH induced colon cancer. (ovid.com)
  • Luteolin, a plant derived flavonoid, exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. (semanticscholar.org)
  • For example, luteolin inhibits the proliferation of lung adenocarcinoma A549 cells via PI3K-Akt-IkBα-Snail signaling pathway by down-regulating the expression of E-cadherin [ 13 ]. (alliedacademies.org)
  • In addition, we found that luteolin suppressed coat protein I complex expression, which was related to influenza virus entry and endocytic pathway. (springermedizin.de)
  • Protein-ligand interactions were determined by executing docking the six TNF-α and NF-κB pathway models, including TNFR1, TRADD, TRAF2, RIP1, and IKKβ, with luteolin using AUTODOCK 4.0 software. (eurekaselect.com)
  • Jui-Chiang Sun, S. T. Wua, Kuei-Jen Lee and Yu-Ming Sun, " Docking Prediction for Luteolin Inhibiting TNF-α and NF-κB Pathway", Letters in Drug Design & Discovery (2012) 9: 169. (eurekaselect.com)
  • These results suggest the role of p21waf1/cip1 pathway in the overcoming BITC resistance by luteolin. (jfda-online.com)
  • NHS Choices , as ever, dissects the study, saying that the research may have homed in on the specific signalling pathway through which luteolin can kill bowel cancer cells in the laboratory. (city-connect.org)
  • 2.Luteolin has anti-tumor effect. (alibaba.com)
  • The luteolin displayed its anti-tumor effects by shrinking the breast cancer cells. (doctorshealthpress.com)
  • Luteolin attenuated the increased levels of serum and renal tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, renal high mobility group box-1 (HMGB1), and nuclear factor kappa β (NF-κB) expression levels in I/R rats. (iitkgp.ac.in)
  • This has been proven time and again in several animal studies - prompting scientists to believe that luteolin can have massive anti-amnesic effects against amyloid toxicity. (naturalpedia.com)
  • Effects of Luteolin on Proliferation and Programmed Cell Death of Human Multiple Myeloma Cell RPMI-8226]. (greenmedinfo.com)
  • The effects of luteolin and chloroquine on expression of cleaved-caspase 3 and LC3 in RPMI8826 cells was detected by Western blot. (greenmedinfo.com)
  • Seelinger G, Merfort I, Wölfle U, Schempp CM (2008) Anti-carcinogenic effects of the flavonoid luteolin. (springer.com)
  • In the present study, the effects of luteolin on chronic cerebral hypoperfusion-associated neurocognitive pathologies were investigated by using rats with permanent bilateral common carotid artery occlusion, a rat model of chronic cerebral hypoperfusion. (sigmaaldrich.com)
  • First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. (medworm.com)
  • Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. (sigmaaldrich.com)
  • Recently, the antitumor effects of luteolin have been extensively investigated in breast and gastric cancer ( 6 ), melanoma ( 7 ), esophageal carcinoma ( 8 ), glioblastoma ( 9 ), hepatocellular carcinoma ( 10 ), placental choriocarcinoma ( 11 ) and lung adenocarcinoma ( 12 ). (spandidos-publications.com)
  • Several studies have reported the involvement of miRNAs in the effects induced by luteolin. (spandidos-publications.com)
  • In the present study, the inhibitory effects of luteolin on the combined toxicity of multi-heavy metals (including zinc, manganese, lead, copper, cadmium, mercury, chromium and nickel) were investigated in HL7702 hepatocyte cells. (spandidos-publications.com)
  • Luteolin has inhibitory effects on several types of malignant tumors. (alliedacademies.org)
  • We have also measured how different concentrations of luteolin effects on cell proliferation of HepG2 over 48 h of window. (alliedacademies.org)
  • Luteolin inhibits NF-κB activity at low micromolar (μM) concentrations, and does not exhibit any cytotoxic effects up to 100 μM. (eurekaselect.com)
  • Read on to learn more about potential benefits and side effects of luteolin. (selfhacked.com)
  • The biological effects of luteolin could be functionally related to each other. (longevityunlocked.com)
  • However, the effects of luteolin on incursion of cancer cells remain unclear. (longevityunlocked.com)
  • Effects of the flavone luteolin, isolated. (ju.edu.jo)
  • At this dose luteolin is safe and no side effects have been reported. (youngnutra.com)
  • In this study, the protective effects of luteolin (1, a major component of Cirsium japonicum) were examined against d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. (sparrho.com)
  • The effects of luteolin exposure were dramatic, resulting in as much as a 90 percent drop in IL-6 production in the LPS-treated cells. (clinicalnews.org)
  • The effects of luteolin on the function of osteoblasts were investigated by measuring cell viability , alkaline phosphatase activity, type I collagen production , osteoprotegerin secretion , Wnt promoter activity, BMP-2 and Runx2 expression and calcified nodule formation. (bvsalud.org)
  • Luteolin has no effects upon osteoblast viability but induced an increase in alkaline phosphatase activity, type I collagen production and a decrease in osteoprotegerin secretion in these cells . (bvsalud.org)
  • Luteolin improved learning and memory abilities as well as novel object recognition ability, and enhanced the proliferation of neurons in the hippocampal dentate gyrus. (nih.gov)
  • Luteolin inhibits the proliferation of RPMI-8226 cells. (greenmedinfo.com)
  • To investigate the effect of Luteolin on proliferation and cell death of human multiple myeloma cell line RPMI-8226 and its mechanisms. (greenmedinfo.com)
  • The luteolin significant inhibited RPMI-8226 cell proliferation in a dose-dependent manner. (greenmedinfo.com)
  • Lapatinib, luteolin or the combination of both inhibited the proliferation of BT474 cells in a dose-dependent manner. (alliedacademies.org)
  • In this paper, we chose Luteolin which is one of the main ingredients of EP and evaluated its effect and metabolism in combination with prednisone. (hindawi.com)
  • Our results showed that oral administration of Luteolin significantly increased the gene and protein expressions of hepatic 11 β -HSD I and renal 11 β -HSD II, which may improve the efficacy and reduce the adverse drug effect of glucocorticoid in clinical application. (hindawi.com)
  • This inhibitory effect can also explain why many doctors suggest using luteolin to alleviate symptoms of multiple sclerosis. (naturalpedia.com)
  • The effect of Luteolin on the growth of human multiple myeloma cell line RPMI-8226 was detected by CCK-8, and then the minimal effective concentration was determined and was used to treat RPMI-8226 cells. (greenmedinfo.com)
  • Whereas luteolin had no effect on the LPS-induced increase in NF-kappaB DNA binding activity, it markedly reduced AP-1 transcription factor binding activity. (greenmedinfo.com)
  • In addition, 20 µM luteolin had a significant inhibitory effect on multi-heavy metal mixture-induced cleavage of caspase-9, caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein. (spandidos-publications.com)
  • The aim of the present study was to unravel the chemopreventive effect of luteolin on bacterial enzymes such as β-glucuronidase and mucinase in a colon carcinogenesis model induced by 1, 2-dimethyl hydrazine (DMH). (ovid.com)
  • This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization. (arvojournals.org)
  • The effect of luteolin on tertiary-butylhydroperoxide (t-BH)-induced ROS production was measured with 2′7′-dichlorofluorescein diacetate. (arvojournals.org)
  • The effect of luteolin on t-BH-induced and hypoxia-induced VEGF transcription and expression were evaluated by RT-PCR and Western blot, respectively. (arvojournals.org)
  • Overall, our findings demonstrated the antiviral effect of luteolin against IAV and its novel antiviral mechanism. (springermedizin.de)
  • Luteolin was found to have the greatest antiproliferative effect of all the substances tested. (supersmart.com)
  • The study did not investigate whether upping one's intake of luteolin-rich foods would have any effect on bowel cancer risk. (city-connect.org)
  • The effect of dietary luteolin on cancer is not clear from this research. (city-connect.org)
  • 23 Jan 2012 --- Luteolin inhibited the growth stimulatory effect of IGF-I and the team led by Prof Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. (nutritioninsight.com)
  • Luteolin inhibited the growth stimulatory effect of IGF-I and the team led by Prof Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. (nutritioninsight.com)
  • In this study, we studied the effect of luteolin on renal I/R injury in rats. (iitkgp.ac.in)
  • Luteolin is often used as an additive treatment for brain damage caused by inflammation. (naturalpedia.com)
  • 3.Luteolin applied in pharmaceutical field, Luteolin can play the role of inflammation. (alibaba.com)
  • Luteolin is also found to suppress two major pathways involved in response to inflammation, which greatly reduces both acute and chronic inflammation . (selfhacked.com)
  • Luteolin treatment in rats reduced brain damage caused by kainic acid by reducing glutamate levels, mitigating inflammation, and enhancing the hippocampus. (selfhacked.com)
  • Herbal traditions around the globe use luteolin-rich plants to strengthen the immune system , relieve inflammation, and even combat cancer [ 1 , 2 ]. (selfhacked.com)
  • Luteolin is considered by some to be a supper nutrient as it helps reduce inflammation, and promotes nerve and muscle function. (longevityunlocked.com)
  • The purpose of the study was to determine if luteolin could also reduce inflammation in the brain, said animal sciences professor and principal investigator Rodney Johnson. (clinicalnews.org)
  • One of the questions we were interested in is whether something like luteolin, or other bioactive food components, can be used to mitigate age-associated inflammation and therefore improve cognitive function and avoid some of the cognitive deficits that occur in aging," Johnson said. (clinicalnews.org)
  • Luteolin has also been found to have antitumor properties and poses special interest for the development of preventive and/or therapeutic agent for cancers. (longevityunlocked.com)
  • As expected, we found that luteolin could attenuate cognitive dysfunction in chronic cerebral hypoperfused rats, as assessed using Morris water maze tests. (sigmaaldrich.com)
  • Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p. (sigmaaldrich.com)
  • Luteolin (0.1, 0.2, or 0.3 mg/kg body weight/everyday (p.o.) was administered in a dose dependent manner at the initiation and also at the post-initiation stages of carcinogenesis to DMH treated rats. (ovid.com)
  • We compared the absorption and metabolism characteristics of NOB with those of luteolin (LT) in male SD rats. (iospress.com)
  • In an experiment on rats with streptozotocin induced Alzheimer's disease , luteolin significantly improved spatial learning and memory impairment. (selfhacked.com)
  • Intragastric administration of luteolin or saline was performed in Sprague-Dawley rats before (40 mg/kg for three days) and after (one day) renal I/R modeling. (iitkgp.ac.in)
  • Pretreatment of primary murine microlgia and BV-2 microglial cells with luteolin inhibited LPS-stimulated IL-6 production at both the mRNA and protein levels. (greenmedinfo.com)
  • Combination of luteolin and lapatinib inhibited the expression of ERBB1 and ERBB2 mRNA and protein in BT474 cells. (alliedacademies.org)
  • Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells. (longevityunlocked.com)
  • In addition, luteolin helps reduce levels of amyloid protein by protecting mitochondria from free radical attack . (supersmart.com)
  • Researchers from Korea showed that luteolin was able to block the secretion of IGF-II by colon cancer cells and within two hours decreased the amount of receptor (IGF-IR) precursor protein. (nutritioninsight.com)
  • Using electromobility shift assays, which measure the binding of transcription factors to DNA promoters, Jang eventually determined that luteolin inhibited IL-6 production by preventing activator protein-1 (AP-1) from binding the IL-6 promoter. (clinicalnews.org)
  • The cells were incubated with different concentrations of luteolin and/or lapatinib. (alliedacademies.org)
  • According to the report of the literature, method for extracting the active ingredient luteolin from the peanut shell includes solvent method, ultrasonic method, microwave method and supercritical CO2 method, wherein the solvent extraction method is the most widely used with the major extraction solvents used being methanol, acetone and ethyl acetate. (chemicalbook.com)
  • Plants rich in luteolin content are often used as a traditional Chinese medicine for treatment of disease. (chemicalbook.com)
  • The recommended daily dose of Mirica ® is equivalent to the amount of luteolin found in one artichoke. (youngnutra.com)
  • luteolin and phospholipid complex was prepared to improve the lipophilic properties of luteolin. (mdpi.com)
  • The study is the first to indicate that luteolin increases cognitive function by acting on the microglial cells. (lifeextension.com)
  • Results indicate that luteolin binds to TNFR1, TRADD, TRAF2, and RIP1 through covalent bonding. (eurekaselect.com)
  • However, long-term administration of luteolin significantly down-regulated the expression of NF-κB and BACE1, accompanied by diminishing the deposition of Aβ. (sigmaaldrich.com)
  • Studies do indicate that the daily supplementation of luteolin can without any doubt provide a boost to the treatment of low testosterone, and we should expect to see this name appearing on many supplement labels in the near future. (lowtestosteroneexpert.com)
  • Luteolin (3,4,5,7-tetrahydroxyflavone) is a natural flavonoid abundant in various fruits and vegetables. (spandidos-publications.com)
  • Jan 23 2012 --- Luteolin is a flavonoid commonly found in fruit and vegetables. (nutritioninsight.com)
  • The pure product of Luteolin appears as yellow crystalline powder. (chemicalbook.com)
  • Figure 1 the pale yellow powder of luteolin and its sources of plant. (chemicalbook.com)
  • Luteolin is the principal yellow dye compound that is obtained from the plant Reseda luteola, which has been used as a source of the dye since at least the first millennium B.C. Luteolin was first isolated in pure form, and named, in 1829 by the French chemist Michel Eugène Chevreul. (wikipedia.org)
  • The results showed that luteolin and phospholipid in the complex were joined by non-covalent-bonds and did not form a new compound. (mdpi.com)
  • Objective:In our study, we have identified synthetic analogues of luteolin from a chemical compound database (E molecule). (elsevier.com)
  • They concluded that although luteolin and paradatiscetin were isomeric (i.e., had the same empirical formula), they were distinct compounds. (wikipedia.org)
  • Although Luteolin is absorbed in humans ( R ), the body metabolizes luteolin and the bioavailability is not great ( R ). (selfhacked.com)
  • Although Luteolin is absorbed in humans ( R ). (selfhacked.com)
  • Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance. (wikipedia.org)
  • Jang found that luteolin inhibited JNK phosphorylation in microglial cell culture. (clinicalnews.org)
  • One Japanese study showed that luteolin can reduce the number and severity of the Japanese encephalitis virus. (naturalpedia.com)
  • In a new study published in the journal Springer Plus , University of Missouri researchers found that luteolin can decrease breast cancer risk in women taking hormone replacement therapy. (doctorshealthpress.com)
  • In this study we checked luteolin activity against number of cell line and according to our screen mouse liver cancer cells (HepG2) is found to be most susceptible to its action. (alliedacademies.org)
  • The study also compared the efficacy of various traditional and modern extraction methods for luteolin extraction. (currentbioactivecompounds.com)
  • Prof Jung Park continued, 'Our study, showing that luteolin interferes with cell signaling in colon cancer cells, is a step forward in understanding how this flavonoid works. (nutritioninsight.com)
  • Result: In the present study, we have successfully identified 3 analogues (flav 10, flav 11, flav 12) which exhibited comparable dock scores (-10.02 -10.438 and -10.083 kcal/mol respectively) when compared to the standard luteolin (-11.472). (elsevier.com)
  • The study leader, Professor Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. (blogspot.com)
  • Prof Jung Han Yoon Park explained, 'Luteolin reduced IGF-I-dependent activation of the cell signaling pathways PI3K, Akt, and ERK1/2 and CDC25c. (nutritioninsight.com)
  • Our results suggest a potential therapeutic use of luteolin for cerebral hypoperfusion associated cognitive dysfunction in AD. (sigmaaldrich.com)
  • The molecular docking results revealed luteolin actually interacted with the primary amino acid residues located within the active site pocket of XO. (nih.gov)
  • Finally Quantitative real time PCR analysis results showed that luteolin significantly up-regulated the expression of both intrinsic and extrinsic caspases as well as executioner caspases. (alliedacademies.org)
  • Results: Hot solvent extraction by reflux technique stood out to be the best technique and methanol was found to be the most effective solvent for luteolin extraction.Through the use of BBD, the optimal conditions for luteolin extraction were established as: solvent to drug ratio- 17.7 mL/g, extraction temperature- 55.5°C and extraction time-2.04 hours. (currentbioactivecompounds.com)