Antipain: An oligopeptide produced by various bacteria which acts as a protease inhibitor.Pneumocytes: Epithelial cells that line the PULMONARY ALVEOLI.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Lung Diseases: Pathological processes involving any part of the LUNG.Pulmonary Surfactants: Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.Lung Neoplasms: Tumors or cancer of the LUNG.Jaagsiekte sheep retrovirus: A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).Pulmonary Surfactant-Associated Protein A: An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.Pulmonary Adenomatosis, Ovine: A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.Pulmonary Surfactant-Associated Proteins: Proteins found in the LUNG that act as PULMONARY SURFACTANTS.Lung Diseases, Interstitial: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.Pulmonary Surfactant-Associated Protein B: A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.Respiratory Mucosa: The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.Plutonium: Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.Macrophages, Alveolar: Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.Pulmonary Surfactant-Associated Protein C: A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.Lung Injury: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Blood-Air Barrier: The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Interferons: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.Middle East: The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).Coronaviridae Infections: Virus diseases caused by CORONAVIRIDAE.Saudi ArabiaCamels: Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.Spike Glycoprotein, Coronavirus: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.Atlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.rap1 GTP-Binding Proteins: A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. They bind to Ras effectors but do not activate them, therefore they may antagonize the effects of RAS PROTEINS. This enzyme was formerly listed as EC 3.6.1.47.rap GTP-Binding Proteins: A family of MONOMERIC GTP-BINDING PROTEINS that are related to RAS PROTEINS.This enzyme was formerly listed as EC 3.6.1.47.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Cervical Atlas: The first cervical vertebra.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.AxisTeaching Materials: Instructional materials used in teaching.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Spondylolisthesis: Forward displacement of a superior vertebral body over the vertebral body below.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Idiopathic Pulmonary Fibrosis: A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Digoxigenin: 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Hahon, N; Castranova, V (1989). "Interferon production in rat type II pneumocytes and alveolar macrophages". Exp Lung Res. 15 ( ...
"Parachlamydia Acanthamoebae Enters and Multiplies within Pneumocytes and Lung Fibroblast". Microbes and Infections. 8 (5): 1294 ... and lyse in human macrophages and pneumocytes. A study in 2003 examined P. acanthamoebae's ability to enter and survive in ...
... , or pneumocytes, are cells lining the alveoli of the lungs. Two types of alveolar cell exist: type I alveolar ... Type I pneumocytes are unable to replicate and are susceptible to toxic insults. In the event of damage, type II cells can ... They are also capable of cellular division, giving rise to more type II alveolar cells when the lung tissue is damaged. These ...
TTF-1 positive cells are found in the lung as type II pneumocytes and club cells. In the thyroid, follicular and parafollicular ... TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in ... small-cell lung carcinomas, neuroendocrine tumors other than small-cell lung carcinomas and extrapulmonary small-cell ... "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung". American Journal of Physiology. Lung Cellular ...
2004). "Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes". Arch. Biochem. ... LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar ... During human fetal development, between weeks 10 and 20, LAMP3 is highly expressed in the lungs, while in normal adult tissue ... "CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes,". Am J ...
This is significant because cortisol induces type II pneumocytes of the lungs to synthesize and secrete pulmonary surfactant; ...
Lung compliance is defined as the volume change per unit of pressure change across the lung. Measurements of lung volume ... It can be both broken down by macrophages and / or reabsorbed into the lamellar structures of type II pneumocytes. Up to 90% of ... The lung's compliance decreases and ventilation decreases when lung tissue becomes diseased and fibrotic. As the alveoli ... extracted from cow lung lavage fluid (Survanta) - extracted from minced cow lung with additional DPPC, palmitic acid and ...
JSRV acutely transforms the lung epithelia into cancerous cells, with type-2 pneumocytes and club cells being the likely target ... The only sign specific to OPA is a watery nasal discharge, consisting of lung fluid produced by the affected lung tissue; ... OPA has been used as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in ... Some of these are small discrete nodules and others will involve the entire half of a lung lobule. ...
The alveolar septum separates adjacent alveoli in lung tissue. The minimal components of an alveolar septum consist of the ... basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium. Thicker alveolar septa ...
... and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung". J. Biol. Chem. 278 (49): 49006-14 ... is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas". FEBS Lett. 462 (1-2): 129- ... The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully ... 2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells". Biochim. Biophys. ...
In humans, this protein was shown to be localized to the human alveolar type II pneumocytes, which synthesize and secrete ... the mice who did not have this protein also displayed a significantly reduced lung capacity in a variety of tests. As LCAD ...
... is a subtype of pneumocytic hyperplasia in the lung. It can be a precursor lesion of in situ ... Kobashi, Y; Sugiu, T; Mouri, K; Irei, T; Nakata, M; Oka, M (2008). "Multifocal micronodular pneumocyte hyperplasia associated ... The needle biopsy rate is less than 1%. Multifocal micronodular pneumocyte hyperplasia (MMPH) in situ pulmonary adenocarcinoma ... "Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: Differentiation from multiple atypical ...
Circulating free fatty acids are directly toxic to pneumocytes and capillary endothelium in the lung, causing interstitial ... Embolized fat travels through the venous system to the lungs and can occlude pulmonary capillaries, fat emboli may cause cor ...
The blood-air barrier (alveolar-capillary barrier or membrane) exists in the gas exchanging region of the lungs. It exists to ... It is formed by the type 1 pneumocytes of the alveolar wall, the endothelial cells of the capillaries and the basement membrane ... ISBN 0-443-07116-0. Anatomy photo: Respiratory/lung/vasc4/vasc - Comparative Organology at University of California, Davis - " ... "Mammal, lung vasculature (EM, High)" Swiss embryology (from UL, UB, and UF) rrespiratory/phasen05. ...
... proteins and glycoproteins that are produced in specialized lung cells called Type II cells or Type II pneumocytes. The ... In addition, the lungs show bleeding, over-distention of airways and damage to the lining cells. The lungs of infants with ... "Insulin inhibits the accumulation of the major lung surfactant apoprotein in human fetal lung explants maintained in vitro". ... The presence of PG usually indicates fetal lung maturity. For the S/A ratio, the result is given as mg of surfactant per gm of ...
Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ... Injury to the lungs and airways is not only due to deposition of fine particulate soot but also due to the gaseous components ... 2008) Animal models of acute lung injury. Am J Physiol. 295:L379-99. Li X, Li S, Zhang M, Li X, Zhang X, Zhang W, Li C. (2010) ...
Type II pneumocyte of lung (surfactant secretion) Club cell of lung Anterior pituitary cells Somatotropes Lactotropes ... Type I pneumocyte (lining air space of lung cell) Pancreatic duct cell (centroacinar cell) Nonstriated duct cell (of sweat ...
Fluid accumulation in the lungs and decreased surfactant production by type II pneumocytes may cause whole air sacs to collapse ... a lung right-to-left shunting occurs within the lungs since some blood from the right side of the heart will enter capillaries ... It is typically provoked by an acute injury to the lungs that results in flooding of the lungs' microscopic air sacs ... The position of lung infiltrates in acute respiratory distress syndrome is non-uniform. Repositioning into the prone position ( ...
Measurement of static lung volumes using body plethysmography or other techniques typically reveals reduced lung volumes ( ... pneumocytes), which line the majority of the alveolar surface. When type I AECs are damaged or lost, it is thought that type II ... Idiopathic pulmonary fibrosis (IPF) belongs to a large group of more than 200 lung diseases known as interstitial lung diseases ... The latter finding reflects the increased lung stiffness (reduced lung compliance) associated with pulmonary fibrosis, which ...
... an air sac in the lungs Alveolar cell or pneumocyte Alveolar duct Alveolar macrophage Mammary alveolus, a milk sac in the ...
It is easily absorbed through the lungs and its inhalation result in heart failure and sometimes death in severe and fatal ... Mucous membrane is primarily affected alongside with type I pneumocyte and the respiratory epithelium. The generation of free ... Nitrogen dioxide is sparingly soluble in water and on inhalation, it diffuses into the lung and slowly hydrolyzes to nitrous ... If chronic exposure causes lungs damage, it could take several days or months for the pulmonary function to improve. Meanwhile ...
The protein encoded by this gene (SP-A2) is primarily synthesized in lung alveolar type II cells (see type II pneumocyte), as ... Using specific monoclonal antibodies for Surfactant protein A, the protein can be detected in lung alveolar type II pneumocytes ... Mutations in the SFTPA2 gene are found in patients with interstitial lung disease and lung cancer. SFTPA2 mutations also ... but also for maintaining lung health, and normal lung function throughout life. Quantitative and/or qualitative alterations in ...
... reticulum cell sarcoma Lung: type II pneumocyte lesions (type II cell hyperplasia, dysplastic type II cells, apical alveolar ... Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins ... Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. Joyce Taylor-Papadimitriou ...
... expressed in type II pneumocytes. Other proteins with elevated expression in the lung are the dynein protein DNAH5 in ciliated ... Humans have two lungs, a right lung and a left lung. They are situated within the thoracic cavity of the chest. The right lung ... These fixed size lungs are called "circulatory lungs", as distinct from the "bellows-type lungs" found in most other animals. ... Some types of chronic lung diseases are classified as restrictive lung disease, because of a restriction in the amount of lung ...
The alveolar epithelium begins to differentiate into two distinct types of cells: type I pneumocytes and type II pneumocytes, ... forming the lung bud. Around the 28th day, during the separation of the lung bud from the foregut it forms the trachea and ... After the lung buds have formed, they begin to grow and branch forming a primitive version of the bronchial tree, determining ... Phases of lung development Morrisey EE, Hogan BL (2010). "Preparing for the first breath: genetic and cellular mechanisms in ...
This affects in the cells action potential profile, as seen in cardiomyocytes, pneumocytes and neurons leading to conduction ... "National Heart, Lung, and Blood Institute. October 1, 2010. Retrieved January 15, 2014.. ... People at higher risk for mold allergies are people with chronic lung illnesses, which will result in more severe reactions ... lung and skin infections are also possible. Mycotoxins may or may not be produced by the invading mold. ...
... infection of a lung pneumocyte. The central cell displays the dramatically enlarged nuclei characteristic of CMV. ... Cytomegalovirus (CMV) infection of a lung pneumocyte. The central cell displays the dramatically enlarged nuclei characteristic ...
Type-II pneumocytes and alveolar macrophages isolated from the lungs of male Sprague-Dawley-rats were inoculated with Ao/PR/8/ ... Interferon production in rat type-II pneumocytes and alveolar macrophages in response to viral stimulation was examined. ... Type-II pneumocytes and alveolar macrophages isolated from the lungs of male Sprague-Dawley-rats were inoculated with Ao/PR/8/ ... The authors conclude that rat type-II pneumocytes are active producers of interferon in response to a viral inducer. Type-II ...
Fingerprint Dive into the research topics of Significance of alveolar macrophages, pneumocyte type II and Clara cells in lung ... Significance of alveolar macrophages, pneumocyte type II and Clara cells in lung toxicology. ...
Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung. American Journal of Clinical ... Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung. In: American Journal of ... Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung. / Chow, Kuan Chih; Hsiao, ... title = "Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung", ...
"A case of micronodular pneumocyte hyperplasia diagnosed through lung biopsy using thoracoscopy". Respiration; international ... Multifocal micronodular pneumocyte hyperplasia (MMPH) is a subtype of pneumocytic hyperplasia (hyperplasia of pneumocytes ... Type II pneumocytes without nuclear atypia lined thickened alveolar septa and proliferated papillary structures. Enlarged ... Shintani, Y; Ohta, M; Iwasaki, T; Ikeda, N; Tomita, E; Nagano, T; Kawahara, K (2010). "A case of micronodular pneumocyte ...
Lung. Krause (2001) Cell 105: 369-377. pneumocytes. Neuronal. Multiple. Marrow. Bjornson (1999) Science 283: 534-537. ... lung, liver, pancreas, kidney, nervous system, skin, bone and skeletal muscle. 28. The use of claim 22, wherein said matrix ...
Hahon, N; Castranova, V (1989). "Interferon production in rat type II pneumocytes and alveolar macrophages". Exp Lung Res. 15 ( ...
Studies on normal lungs show that 7% of the alveolar surface is covered by type II pneumocytes, which make up 16% of the total ... lung tissue was obtained by open lung biopsy from two different sites, most often the upper and lower lobes of the same lung. ... Sections of lung from patients with usual interstitial pneumonia examined by electron microscopy. (A) Type II pneumocytes ... Because type I pneumocytes are produced by the proliferation and transformation of type II pneumocytes, the progressive ...
SARS-CoV primarily targeted ciliated HAEs and type 1 and 2 pneumocytes in the lung (13, 23). In ex vivo human lung cultures, ... Recombinant virus growth in primary human lung cells. HAEs, primary alveolar type II pneumocytes, primary lung microvascular ... pneumocytes, lung microvascular endothelial (MVE) cells, and lung fibroblasts (FBs). SARS-CoV did not replicate in any of the ... primary lung fibroblasts, primary lung microvascular endothelial cells, and primary alveolar type II pneumocytes, demonstrating ...
Lung cancer is the major cause of death among cancer patients. OPA can be an extremely useful animal model in order to identify ... Importantly, induction of lung injury increased dramatically the number of LAPCs in adult sheep and rendered these animals ... JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major ... In this study, we demonstrated that lung adenocarcinoma in sheep originates from infection and transformation of proliferating ...
a) CXCL1 expression on type 2 pneumocytes. (b) Alveolar macrophages positive for CXCL1. (c) Type II pneumocytes positive for ... A three-state model was developed to assess the likelihood of transitioning from lung transplant (state 1) to BOS (state 2), ... Pseudomonas aeruginosa is the most commonly isolated gram-negative bacterium after lung transplantation and has been shown to ... Movement from transplant to death was facilitated by pseudomonas infection and single lung transplant. Transition from BOS to ...
hAT-MSCs give rise to type 2 pneumocyte-like cells, and to Clara-like cells that line the airways when cultured in the lung ... Lung bioreactor cultures seeded with hBM-MSCs. (A) H&E histological section of lungs seeded with hBM-MSCs and cultured for 7 ... A) hAT-MSCs robustly repopulate the lung matrix following 7 days of culture in SAGM in the acellular rat lung bioreactor. H&E ... Identification of appropriate donor cell types is important for lung cell therapy and for lung regeneration. Previous studies ...
Inferior part of pleural cavity not occupied by lung (between diaphragm and rib cage) ... What percentage of the alveoli surface area do T1 and T2 pneumocytes cover? ...
These results show that MKK7 functions as a major tumor suppressor in lung and mammary cancer in mouse and identify MKK7 as a ... Here we report that tissue-specific inactivation of the stress signaling kinase MKK7 in KRasG12D-driven lung carcinomas and ... Josef Penninger and colleagues show that deletion of the stress kinase MKK7 in mouse models of lung and mammary tumors ... Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. Am. J. Physiol. Lung Cell. Mol. Physiol. ...
Lung zones: V/Q at the apex of lung=3 (wasted ventilation); V/Q at base of lung=0.6 (wasted perfusion). Both ventilation and ... Type I pneumocytes They cover 97% of alveolar surfaces and line the alveoli. They are squamous; Thin is optimal for gas ... The right lung has three lobes; Left has Less Lobes (2) and Lingula (homolog of the right middle lobe). The right lung is more ... Restricted lung expansion causes a decrease in lung volumes (decrease in FVC and TLC). PFTs will show FEV1/FVC ratio is equal ...
Ultrastructural pathology of the alveolar type II pneumocytes of human donor lungs. Electron microscopy, stereology, and ... Effect of interleukin-1beta inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory ... Division of Asthma Exacerbation & Regulation, Priority Area Asthma and Allergy, Leibniz Lung Center Borstel, Airway Research ... and airway remodeling in the adult murine lung. Am. J.Respir. Cell Mol. Biol. 32, 311-318 (2005). ...
... in lung tissue. Antibody staining with HPA001922 in immunohistochemistry. ... Pneumocytes: 40. Bronchial epithelium: 5. Endothelial cells: 25. Macrophages: 10. Other cell types: 20. ... Lung cancer. Melanoma. Ovarian cancer. Pancreatic cancer. Prostate cancer. Renal cancer. Stomach cancer. Testis cancer. Thyroid ... Lung. Lymph node. Nasopharynx. Oral mucosa. Ovary. Pancreas. Parathyroid gland. Pituitary gland. Placenta. Prostate. Rectum. ...
Viral antigen was detected in pneumocytes by immunohistochemical tests. Tumor necrosis factor-α mRNA was seen in lung tissue. ... and the major site of H5N1 viral replication in the lung is the pneumocyte. ... However, limited previous data from human autopsies have not shown evidence of virus dissemination beyond the lung. We ... Viral RNA was detected by reverse transcription-polymerase chain reaction in lung, intestine, and spleen tissues, but positive- ...
Also, the study has shown that such cells are most pervasive in the liver, lungs and spleen when all of the tissues are ... E-F) Immunofluorescence for virus antigen expression in pneumocytes. (E) nucleocapsid of SARS-CoV-2 (Green); (F) negative ... Characteristic pathological changes and virus antigen expression in the lungs of one SARSr-CoV-2 positive pangolin . (A-C) An ... Furthermore, computed tomography (CT) scan revealed diffused bilateral distribution of ground-glass opacities in the lungs, ...
What part of the type II pneumocyte released surfactant?. lamellar bodies. What do bronchiolar exocrine cells do and how are ... reduces the surface tension in the lungs faciltating exoansion and preventing collapse. ... Which pneumocytes are more abundant?. Type II @ ~60%, but they only cover ~5% of alveolar surface. ... 1. type I pneumocytes and surfactant layer 2. basal lamina 3. endothelium (inside capillary). ...
... histologically normal lung tissue from a control patient. M, alveolar macrophage; P, pneumocyte; F, fibroblast; L, lymphocyte. ... The cause of ARDS/ALI was direct lung injury in 22 patients (related to pneumonia, n = 12; lung resection, n = 6; aspiration ... In this part of the study, patients undergoing lung resection for malignancy (n = 9), in whom lung tissue (normal appearance on ... Background: Acute lung injury (ALI) and its extreme manifestation the acute respiratory distress syndrome (ARDS) complicate a ...
2012) Influenza A viruses target type II pneumocytes in the human lung. J Infect Dis 206:1685-1694. ... B) Forty-eight hours after challenge with KGF, lungs were harvested and dissociated, and dispersed lung cells were stained with ... C) Seventy-two hours after challenge with KGF, lungs were harvested and dissociated, and dispersed lung cells were stained with ... Preparation of Dispersed Cells from Whole Lung.. Explanted lungs were instilled with 5,000 caseinolytic units (c.u.)/mL dispase ...
The type II pneumocytes showed reactive hyperplasia without cytopathic changes. Predominant macrophage infiltrates in the lung ... H5N1 virus genomic sequence has been identified in fetal lung tissue without severe lung injury compared with severe adult lung ... Influenza is an acute infection of the respiratory tract that involves the nose, throat, and, sometimes, the lungs. Following ... 10] Lung changes include diffuse alveolar damage, interstitial pneumonia, bronchiolitis, and hemorrhages. ...
SBP is produced by type II pneumocytes in the alveoli. An increase of its plasmatic levels is correlated to a decay of ... Lung Diseases. Anesthetics. Carbon Monoxide. Central Nervous System Depressants. Physiological Effects of Drugs. ... Evaluation of Gas Exchange by the Measurement of Lung Diffusion for Carbon Monoxide During General Anaesthesia. The recruitment ... is able to induce lung injury (as shown by histologic findings). The most sensitive and specific tools the investigators can ...
Coronavirus predominantly infects type II pneumocytes in the human lung. Previously, it was demonstrated that SARS-CoV-2 cell ... In type II pneumocytes, TMPRSS2 expression is associated with an increase in androgen receptor (AR) expression, specifically ...
  • Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation. (nih.gov)
  • Pseudomonas aeruginosa is the most commonly isolated gram-negative bacterium after lung transplantation and has been shown to up-regulate glutamic acid-leucine-arginine-positive (ELR(+)) CXC chemokines associated with bronchiolitis obliterans syndrome (BOS), but the effect of pseudomonas on BOS and death has not been well defined. (nih.gov)
  • Ventilator-dependent patients are considered poor candidates for lung transplantation. (bmj.com)
  • A single lung transplantation was carried out with a successful outcome. (bmj.com)
  • Although ventilator dependence has traditionally been regarded as a relative contraindication for lung transplantation, candidates who deteriorate while on a waiting list and patients who develop acute respiratory failure in the absence of any associated organ dysfunction represent unique situations that merit cautious examination. (bmj.com)
  • Partial cardiopulmonary bypass was instituted and lung transplantation was performed through a standard thoracotomy in the fifth intercostal space. (bmj.com)
  • In this report, we investigated a case of fatal H5N1 disease in a child for tissue tropism caused by the virus in the lungs and other organs. (cdc.gov)
  • Although the vascular niche is anatomically and functionally well-characterized in several organs such as bone marrow and neurons, the effects of endothelial signals on other resident cells and anatomy of the vascular niche in the lung have not been well-explored. (frontiersin.org)
  • Therefore, the lung is one of the most vital organs in the human body. (frontiersin.org)
  • Toxicity from hydrocarbon ingestion can affect many different organs, but the lungs are the most commonly affected. (medscape.com)
  • In addition, ExlA conferred on bacteria the capacity to proliferate in lungs and to disseminate in secondary organs, similar to bacteria possessing a functional T3SS. (archives-ouvertes.fr)
  • P2X 7 R −/− mice failed to increase surfactant secretion in response to hyperventilation, pointing to the physiological relevance of P2X 7 R in maintaining surfactant homeostasis in the lung. (biologists.org)
  • Coronavirus predominantly infects type II pneumocytes in the human lung. (clinicaltrials.gov)
  • SPA is an animal model of human bronchioloalveolar carcinoma (BAC) ( 45 ), a human lung cancer that is not etiologically associated with smoking ( 29 ) and that is increasing in prevalence in the United States ( 6 ). (asm.org)
  • Human lung cancer is a disease with high incidence and accounts for most cancer-related deaths in both men and women. (aacrjournals.org)
  • Analyses of data from The Cancer Genome Atlas (TCGA) revealed that expression, promoter methylation, or copy number of CEBPB was not significantly altered in human lung adenocarcinoma. (jove.com)
  • It is expressed at high levels in human lung and kidney, and at lower levels in spleen. (clontech.com)
  • High frequency jet ventilation was applied on the left lung until clamping of the pulmonary artery. (bmj.com)
  • Lungs of heart failure patients undergo extensive remodeling ( 18 , 25 , 26 ), resulting in architectural changes such as pulmonary artery and vein wall thickening, pulmonary arteriole muscularization, and capillary endothelial and alveolar epithelial basement membrane thickening ( 18 ). (physiology.org)
  • Fetal circulation is marked by right-to-left shunting of blood around the unventilated lungs through a patent ductus arteriosus (connecting the pulmonary artery to the aorta) and foramen ovale (connecting the right and left atria). (merckmanuals.com)
  • Because the lungs are not ventilated, only a small amount of blood needs to go through the pulmonary artery. (merckmanuals.com)
  • (A) H&E histological section of lungs seeded with hBM-MSCs and cultured for 7 days in small airway growth medium (SAGM). (nih.gov)
  • Lung dynamic behavior has different components, and many studies have focused on separating the effects of tissue dissipation and flow through the airway tree on lung resistance, and on the effects of surface tension in elastance (4,5). (scielo.br)
  • Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Other investigators detected E 2 -induced proliferation and activation of intracellular MAPK and PI3K by ERα, ERβ, GPR30, and epidermal growth factor receptor (EGFR) in lung adenocarcinoma cell lines in a gender-independent manner ( 4 , 5 ). (pubmedcentralcanada.ca)
  • The right lung is bigger than the left, which shares space in the chest with the heart . (wikipedia.org)
  • The right lung has three lobes and the left has two. (wikipedia.org)
  • Around 2010, chest radiography revealed bilateral reticulonodular opacities and decreased lung volumes, with right lung predominance ( fig. 1a ). (ersjournals.com)
  • Computed tomography showed small lung volumes, reticular opacities, airspace consolidation, diffuse traction bronchiectasis and cystic changes, mainly in the right lung ( fig. 1b ). (ersjournals.com)
  • a) Chest radiography shows reduced lung volumes and reticulonodular shadows, mainly in the right lung. (ersjournals.com)
  • c) Chest radiography shows complete collapse of the right lung. (ersjournals.com)
  • Chest radiography showed complete collapse of the right lung ( fig. 1c ), and the patient was diagnosed as having secondary pneumothorax caused by HPS. (ersjournals.com)
  • The left lung (pulmo sinister) is subdivided into two, the right lung (pulmo dexter) into three lobes (lobi pulmonis). (doccheck.com)
  • The right lung consists of 10 segments, the left lung of 9 segments. (doccheck.com)
  • Conventional mechanical ventilation was applied selectively on the right lung with inhaled NO (8-15 ppm). (bmj.com)
  • Therefore, it is critically important to understand the innate alveolar repair programs in order to prevent or treat end-stage lung diseases. (frontiersin.org)
  • The tissue of the lungs can be affected by a number of diseases , including pneumonia and lung cancer . (wikipedia.org)
  • The regulation of extracellular matrix remodeling, in normal conditions or in several pulmonary diseases, such as ARDS, results from a complex mechanism that integrate the transcription of elements that destroy the matrix protein and produce activation/inhibition of several cellular types of lung tissue. (scielo.br)
  • The UC Heart, Lung and Vascular Institute builds upon its nationally known cardiovascular diseases discoveries to make significant contributions to research, education and patient care. (uc.edu)
  • People with TSC can be affected with many other lung diseases, just like everyone else in the community. (tsa.org.au)
  • Mutations within the ABCA3 gene may functionally impair the transporter, causing lung diseases in newborns, children and adults. (uni-muenchen.de)
  • These results explicate novel aspects of local GC:retinoid interactions that may contribute to alveolar tissue remodeling in chronic lung diseases that affect children and, possibly, adults. (plos.org)
  • Furthermore, computed tomography (CT) scan revealed diffused bilateral distribution of ground-glass opacities in the lungs, akin to the early phase COVID-19 pneumonia. (news-medical.net)
  • High resolution computed tomography (HRCT) showed ground glass opacities on bilateral lower lungs. (hindawi.com)
  • Because oxygenation could not be maintained by single-lung ventilation during the surgery, intermittent bilateral lung ventilation was adopted. (ersjournals.com)
  • The plasma creatinine level was raised (272 μM/l) and bilateral lung infiltrates were seen on the chest radiograph. (bmj.com)
  • Although activation of A 3 adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. (springer.com)
  • Herein, the ability of hBM-MSCs and hAT-MSCs to repopulate acellular rodent lung tissue was evaluated. (nih.gov)
  • Cellular atypia in rodent lungs is characterized by one or more of the following features: cytoplasmic basophilia, hyperchromatic nuclei, loss of nuclear polarity, high nuclear to cytoplasmic ratio, karyomegaly, anisokaryosis, and pleomorphism. (nih.gov)
  • Lung cancer is the main cause of mortality among cancer patients ( 32 ), and the characteristics BAC and SPA have in common suggest that the latter could offer novel insights into pulmonary carcinogenesis. (asm.org)
  • Interestingly, breast cancer patients receiving antiestrogens for breast cancer had lower lung cancer mortality, indicating a possible role for estrogens in disease progression ( 2 ). (pubmedcentralcanada.ca)
  • The left lung shares space with the heart, and has an indentation in its border called the cardiac notch of the left lung to accommodate this. (wikipedia.org)
  • A three-state model was developed to assess the likelihood of transitioning from lung transplant (state 1) to BOS (state 2), from transplant (state 1) to death (state 3), and from BOS (state 2) to death (state 3). (nih.gov)
  • Pseudomonas and the ELR(+) CXC chemokines may interact to negatively influence lung transplant outcomes. (nih.gov)
  • After a multidisciplinary consultation he was accepted as a candidate for an urgent lung transplant since there was no evidence of a septic state or an associated organ failure, and the patient's relatives denied a suicidal attempt. (bmj.com)
  • p = 0.002) and higher frequency of primary graft (PGD) dysfunction after lung transplant (p = 0.02). (nih.gov)
  • however, its roles on normal lung homeostasis and lung cancer development have not been well described. (jove.com)
  • These cysts take the place of the normal fine lacy pattern of the normal lung. (tsa.org.au)
  • A balance between the actions of retinoids and glucocorticoids (GCs) promotes normal lung development and, in particular, alveolarization. (plos.org)
  • Using this approach, our laboratory has identified several receptors and signaling proteins that participate in mechanotransduction in fetal lung development and lung injury. (jove.com)
  • The most significant improvement in survival from ALI/ARDS results from limiting the extent to which mechanical ventilation exacerbates existing lung injury. (bmj.com)
  • A recent study about the effect of positive end-expiratory pressure (PEEP) on DLCO (diffusing capacity of the lung for carbon monoxide) in patients undergoing invasive mechanical ventilation has proved that patients without any evident pulmonary disease (negative medical history, negative chest clinical examination, normal chest X-ray radiography and normal arterial oxygen tension [PaO after 24 hours of invasive mechanical ventilation show a significant worsening of pulmonary gas exchange properties. (clinicaltrials.gov)
  • This hypothesis finds support in some studies carried out on animal models which founds that mechanical ventilation, even when low tidal volumes (Vt) are set for a few hours, is able to induce lung injury (as shown by histologic findings). (clinicaltrials.gov)
  • The primary end-point of this study is to evaluate the changes of anatomical (SPB) and functional (DLCO) features of alveolar-capillary membrane between the spontaneous breathing and mechanical ventilation as well as the progressive changes affecting DLCO and SPB over time during general anaesthesia and mechanical ventilation in patients with otherwise healthy lung undergoing elective surgery. (clinicaltrials.gov)
  • Effects of General Anaesthesia and Invasive Mechanical Ventilation on Alveolo-capillary Membrane: Evaluation of Gas Exchange by the Measurement of Lung Diffusion for Carbon Monoxide (DLCO) and Plasma Dosage of Surfactant Protein-B (SPB). (clinicaltrials.gov)
  • Mechanical ventilatory support was continued for five weeks until a suitable lung donor was found. (bmj.com)
  • After a cold ischaemia time of 270 minutes the donor lung was reperfused and conventional mechanical ventilation was resumed on both lungs with the application of a PEEP of 5 cm H 2 O. Weaning from cardiopulmonary bypass was successful with inotropic support (epinephrine 0.1 μg/kg/min). (bmj.com)
  • Mechanical forces contribute to neonatal lung growth: the influence of altered diaphragm function in. (biomedsearch.com)
  • Hence, paraquat poisoning provides a suitable model of acute lung injury with alveolar instability that can be easily used in experimental protocols of mechanical ventilation. (scielo.br)
  • Due to its simplicity (single ip administration), low cost and rapid effect, paraquat intoxication is a suitable model of acute lung injury to be used in protocols of mechanical ventilation. (scielo.br)
  • In type II pneumocytes, TMPRSS2 expression is associated with an increase in androgen receptor (AR) expression, specifically connecting AR expression to SARS-CoV-2, due to AR-regulated TMPRSS2 gene promoter. (clinicaltrials.gov)
  • Finally the JSRV 21 LTR contains putative enhancer binding motifs for transcription factors such as hepatocyte nuclear factor 3 (HNF-3) that are involved in lung-specific gene expression. (asm.org)
  • A MUC1 gene polymorphism for the large MUC1 allele was associated with lung adenocarcinoma but not with squamous cell carcinoma ( 10 ). (pubmedcentralcanada.ca)
  • Discoidin domain receptor 1 (DDR1) 3 is a receptor tyrosine kinase that is activated by binding to its ligand-collagen, including collagen type IV ( 1 , 2 ), a component of the extracellular matrix (ECM) of the lungs. (jimmunol.org)
  • Differential Replication, Lung Tissue Tropism, and Inflammatory and Innate Immune Responses in Macaques Infected with H5N1 and 1918 Reassortant Influenza Viruses. (pnas.org)
  • Studies were performed in an in vivo spontaneously breathing cat model, in which the left lower lobe of the lung was isolated and subjected to 2 hours of ischemia and 3 hours of reperfusion. (springer.com)