The transference of either one or both of the lungs from one human or animal to another.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The transference of a part of or an entire liver from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transference of a kidney from one human or animal to another.
Pathological processes involving any part of the LUNG.
The transference of a heart from one human or animal to another.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Transplantation of an individual's own tissue from one site to another site.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Prospective patient listings for appointments or treatments.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transference of an organ between individuals of the same species or between individuals of different species.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Tumors or cancer of the LUNG.
The transference of a pancreas from one human or animal to another.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Elements of limited time intervals, contributing to particular results or situations.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the BRONCHI. This results in a floppy bronchial wall making patency difficult to maintain. It is characterized by wheezing and difficult breathing.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
Endoscopic examination, therapy or surgery of the bronchi.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A specific type of health insurance which provides surgeons' fees for specified amounts according to the type of surgery listed in the policy.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Ratings that express, in numerical values, the degree of impairment or abnormality in the function of specific organs.
The period following a surgical operation.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
The return of a sign, symptom, or disease after a remission.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Pathological process resulting in the fibrous obstruction of the small- and medium-sized PULMONARY VEINS and PULMONARY HYPERTENSION. Veno-occlusion can arise from fibrous proliferation of the VASCULAR INTIMA and VASCULAR MEDIA; THROMBOSIS; or a combination of both.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
A dead body, usually a human body.
The excision of lung tissue including partial or total lung lobectomy.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Disease having a short and relatively severe course.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Transplantation between animals of different species.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
The circulation of the BLOOD through the LUNGS.
Infections with bacteria of the genus BURKHOLDERIA.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Infection of the lung often accompanied by inflammation.
Partial or total replacement of the CORNEA from one human or animal to another.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
Planning for the equitable allocation, apportionment, or distribution of available health resources.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
A condition associated with VENTRICULAR SEPTAL DEFECT and other congenital heart defects that allow the mixing of pulmonary and systemic circulation, increase blood flow into the lung, and subsequent responses to low oxygen in blood. This complex is characterized by progressive PULMONARY HYPERTENSION; HYPERTROPHY of the RIGHT VENTRICLE; CYANOSIS; and ERYTHROCYTOSIS.
Inflammation of the lung parenchyma that is caused by a viral infection.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
Pathological processes of the LIVER.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.

Bronchial artery perfusion scintigraphy to assess bronchial artery blood flow after lung transplantation. (1/1390)

The bronchial arterial system is inevitably interrupted in transplanted lungs when removing the organs from the donor, but it can be reestablished by direct bronchial artery revascularization (BAR) during implantation. The purpose of this study was to visualize and quantify the distribution of bronchial artery perfusion after en bloc double lung transplantation with BAR, by injecting radiolabeled macroaggregated albumin directly into the bronchial artery system. METHODS: BAR was performed using the internal mammary artery as conduit. Patients were imaged 1 mo (n = 13) or 2 y (n = 9) after en bloc double lung transplantation with BAR. Immediately after bronchial arteriography, 100 MBq macroaggregated albumin (45,000 particles) were injected through the arteriographic catheter. Gamma camera studies were then acquired in the anterior position. At the end of imaging, with the patient remaining in exactly the same position, 81mKr-ventilation scintigraphy or conventional intravenous pulmonary perfusion scintigraphy or both were performed. Images were evaluated by visual analysis, and a semiquantitative assessment of the bronchial arterial supply to the peripheral parts of the lungs was obtained with conventional pulmonary scintigraphy. RESULTS: The bronchial artery scintigraphic images showed that the major part of the bronchial arterial flow supplied central thoracic structures, but bronchial artery perfusion could also be demonstrated in the peripheral parts of the lungs when compared with conventional pulmonary scintigraphy. There were no differences between scintigrams obtained from patients studied 1 mo and 2 y post-transplantation. CONCLUSION: Total distribution of bronchial artery supply to the human lung has been visualized in lung transplant patients. This study demonstrates that this nutritive flow reaches even the most peripheral parts of the lungs and is present 1 mo as well as 2 y after lung transplantation. The results suggest that bronchial artery revascularization may be of significance for the long-term status of the lung transplant.  (+info)

Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. (2/1390)

Human cytomegalovirus (HCMV) infection was monitored retrospectively by qualitative determination of pp67 mRNA (a late viral transcript) by nucleic acid sequence-based amplification (NASBA) in a series of 50 transplant recipients, including 26 solid-organ (11 heart and 15 lung) transplant recipients (SOTRs) and 24 bone marrow transplant recipients (BMTRs). NASBA results were compared with those obtained by prospective quantitation of HCMV viremia and antigenemia and retrospective quantitation of DNA in leukocytes (leukoDNAemia). On the whole, 29 patients were NASBA positive, whereas 10 were NASBA negative, and the blood of 11 patients remained HCMV negative. NASBA detected HCMV infection before quantitation of viremia did but after quantitation of leukoDNAemia and antigenemia did. In NASBA-positive blood samples, median levels of viremia, antigenemia, and leukoDNAemia were significantly higher than the relevant levels detected in NASBA-negative HCMV-positive blood samples. By using the quantitation of leukoDNAemia as the "gold standard," the analytical sensitivity (47.3%), as well as the negative predictive value (68. 3%), of NASBA for the diagnosis of HCMV infection intermediate between that of antigenemia quantitation (analytical sensitivity, 72. 3%) and that of viremia quantitation (analytical sensitivity, 28.7%), while the specificity and the positive predictive value were high (90 to 100%). However, with respect to the clinically relevant antigenemia cutoff of >/=100 used in this study for the initiation of preemptive therapy in SOTRs with reactivated HCMV infection, the clinical sensitivity of NASBA reached 100%, with a specificity of 68. 9%. Upon the initiation of antigenemia quantitation-guided treatment, the actual median antigenemia level was 158 (range, 124 to 580) in SOTRs who had reactivated infection and who presented with NASBA positivity 3.5 +/- 2.6 days in advance and 13.5 (range, 1 to 270) in the group that included BMTRs and SOTRs who had primary infection (in whom treatment was initiated upon the first confirmation of detection of HCMV in blood) and who presented with NASBA positivity 2.0 +/- 5.1 days later. Following antiviral treatment, the durations of the presence of antigenemia and pp67 mRNA in blood were found to be similar. In conclusion, monitoring of the expression of HCMV pp67 mRNA appears to be a promising, well-standardized tool for determination of the need for the initiation and termination of preemptive therapy. Its overall clinical impact should be analyzed in future prospective studies.  (+info)

Retransplantation in a patient with cystic fibrosis. (3/1390)

A patient with cystic fibrosis is described who requested a third lung transplant. The medical and ethical issues involved are discussed.  (+info)

Recurrence of bronchioloalveolar carcinoma in transplanted lungs. (4/1390)

BACKGROUND: Bronchioloalveolar carcinoma is a distinctive subtype of typical adenocarcinoma of the lung that tends to metastasize widely throughout the lungs but less commonly elsewhere. Because conventional therapies for intrapulmonary metastatic bronchioloalveolar carcinoma are generally ineffective, we treated seven patients who had intrapulmonary metastatic bronchioloalveolar carcinoma with lung transplantation. METHODS: Seven patients with biopsy-proved bronchioloalveolar carcinoma and no evidence of extrapulmonary disease received transplants of either one or two cadaveric lungs. At transplantation, all native lung tissue was removed and replaced with a donor lung or lungs. The patients received the usual post-transplantation care given at the institution. RESULTS: Four of the seven patients had recurrent bronchioloalveolar carcinoma within the donor lungs; the recurrences appeared from 10 to 48 months after transplantation. All recurrences were limited to the donor lungs. Histologic and molecular analyses showed that the recurrent tumors in three patients originated from the recipients of the transplants. CONCLUSIONS: Lung transplantation for bronchioloalveolar carcinoma is technically feasible, but recurrence of the original tumor within the donor lungs up to four years after transplantation was common.  (+info)

Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease. (5/1390)

BACKGROUND: Alpha-1 antitrypsin (alpha 1-AT) is the most abundant proteinase inhibitor within the lung. We have recently reported the surprising observation that cystic fibrosis patients with mild to moderate deficiency of alpha 1-antitrypsin have significantly better pulmonary function than non-deficient patients. This study may have been biased as it did not include the most severely affected patients who have died in childhood or those who have undergone orthotopic lung transplantation. The prevalence of alpha 1-antitrypsin deficiency alleles in this most severely affected group of patients with cystic fibrosis was therefore assessed. METHODS: DNA was obtained from neonatal blood spots from children with cystic fibrosis who had died from pulmonary disease and from formalin fixed lung tissue from transplanted cystic fibrosis patients. The common S and Z deficiency alleles of alpha 1-AT were sought by amplification mutagenesis of the appropriate region of the alpha 1-AT gene followed by restriction enzyme digestion with Xmn I and Taq I, respectively. RESULTS: Seventy-nine patients were identified (seven dead, 72 transplanted). Two patients (2.5%) were heterozygous for the Z allele of alpha 1-AT and four (5.1%) were heterozygous for the S allele. This is not significantly different from the incidence in the normal population of 4% and 8% for the S and Z alleles, respectively. CONCLUSIONS: These data support previous findings that deficiency of alpha 1-AT is not associated with more severe pulmonary disease in cystic fibrosis and may be associated with milder lung disease. Further work is needed to clarify the mechanisms underlying the progressive lung damage in cystic fibrosis.  (+info)

Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases. (6/1390)

The MR imaging findings of fungal spinal osteomyelitis in three recipients of organ transplants showed hypointensity of the vertebral bodies on T1-weighted sequences in all cases. Signal changes and enhancement extended into the posterior elements in two cases. Multiple-level disease was present in two cases (with a total of five intervertebral disks involved in three cases). All cases lacked hyperintensity within the disks on T2-weighted images. In addition, the intranuclear cleft was preserved in four of five affected disks at initial MR imaging. MR features in Candida and Aspergillus spondylitis that are distinct from pyogenic osteomyelitis include absence of disk hyperintensity and preservation of the intranuclear cleft on T2-weighted images. Prompt recognition of these findings may avoid delay in establishing a diagnosis and instituting treatment of opportunistic osteomyelitis in the immunocompromised patient.  (+info)

Exogenous surfactant improves survival and surfactant function in ischaemia-reperfusion injury in minipigs. (7/1390)

Reperfusion injury is the major cause of early morbidity and mortality after lung transplantation. This complication has been experimentally linked to dysfunction of pulmonary surfactant. Therefore, the hypothesis that reperfusion injury might be preventable by exogenous surfactant treatment was tested. Left lungs of minipigs were exposed to 120 min of ischaemia, and the lungs were then reperfused for up to 7 h. Animals were divided into a control group and a surfactant group (n=5 each). The surfactant group received 50 mg x kg(-1) Alveofact intrabronchially via a bronchoscope at the beginning of the ischaemic period. Bronchoalveolar lavage was performed at baseline before ischaemia and 90 min after reperfusion. Surfactant treatment significantly improved short-term survival. Pulmonary vascular resistance increased markedly in control animals leading to right heart failure and death within 3 h after reperfusion whereas the surfactant-treated animals survived the 7 h observation period. After reperfusion, alveolar accumulation of neutrophils and exuded proteins was present in both groups to the same extent. Surfactant activity after reperfusion deteriorated markedly in the control group but was preserved in the surfactant group. In conclusion, early surfactant treatment alleviates the deterioration of surfactant function and improves survival in this minipig model of ischaemia-reperfusion injury.  (+info)

Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cells. (8/1390)

The inflammatory pathogenesis in airways of patients with cystic fibrosis (CF) is still unresolved. We demonstrate here that in in situ human DeltaF508 homozygous CF bronchial tissues, submucosal gland cells exhibit an absence of inhibitor factor kappaBalpha (IkappaBalpha) and high levels of chemokine interleukin-8 (IL-8) expression. These results were confirmed by cultured human CF bronchial gland cells in which a lack of cytosolic IkappaBalpha and high levels of constitutively activated nuclear factor kappaB (NFkappaB) associated with an up-regulation of IL-8 production (13-fold increase) were found when compared to non-CF (control) disease bronchial gland cells. We also demonstrated that the isoflavone genistein, a well known CFTR mutant Cl(-) channel stimulator, significantly reduces the endogenous and Pseudomonas aeruginosa lipopolysaccharide-induced IL-8 production in cultured CF bronchial gland cells by increasing cytosolic IkappaBalpha protein levels. Overall, results show that genistein is a potent inhibitor of the activated NFkappaB identified in CF gland cells. This strong inhibition of constitutively activated NFkappaB and the resulting down-regulation of IL-8 production by genistein in the CF gland cells highlights the key role played by cytosolic IkappaBalpha in the regulation of inflammatory processes in CF human airway cells.  (+info)

Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. The unilateral shift values on Q-scinti were calculated and compared between the CLAD group (N=27) and the non-CLAD group (N=31) from 5 years before to 5 years after the diagnosis of CLAD. The unilateral shift values in Q-scinti were significantly higher in the CLAD group than in the non-CLAD group from 5 years before the diagnosis of CLAD to 5 years after the diagnosis ( ...
TY - JOUR. T1 - Stage I adenocarcinoma presenting in the pneumonectomy specimen at the time of single lung transplantation. AU - Svendsen, Charles A.. AU - Bengtson, Ross B.. AU - Park, Soon J.. AU - Shumway, Sara J.. PY - 1998/10/27. Y1 - 1998/10/27. N2 - Two patients at our institution underwent single lung transplantation. The procedure and the patients postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lung showed no evidence of adenocarcinoma and all lymph nodes were negative. Work-ups for an occult malignancy before and after surgery were negative. This is believed to be the first report of a single lung transplant in a patient with a primary adenocarcinoma of the lung. The implications and management of these patients are discussed.. AB - Two patients at our institution underwent single lung transplantation. The procedure and ...
TY - JOUR. T1 - Surgical issues in lung transplantation. T2 - Options, donor selection, graft preservation, and airway healing. AU - Daly, Richard C.. AU - Mcgregor, Christopher G.A.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1997. Y1 - 1997. N2 - To present an overview of the surgical issues in lung transplantation, including the historical context and the rationale for choosing a particular procedure for a specific patient, we reviewed and summarized the current medical literature and our personal experience. Several surgical options are available, including single lung transplantation; double lung transplantation; heart-lung transplantation; bilateral, sequential single lung transplantation; and (recently) single lobe transplantation. Although single lung transplantation is preferred for maximal use of the available organs, bilateral lung transplantation is necessary for septic lung diseases and may be appropriate for pulmonary hypertension and bullous ...
TY - JOUR. T1 - Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome. AU - Date, Hiroshi. AU - Sano, Yoshifumi. AU - Aoe, Motoi. AU - Goto, Keiji. AU - Tedoriya, Takeo. AU - Sano, Shunji. AU - Andou, Akio. AU - Shimizu, Nobuyoshi. PY - 2002/1/1. Y1 - 2002/1/1. UR - UR - U2 - 10.1067/mtc.2002.119331. DO - 10.1067/mtc.2002.119331. M3 - Article. C2 - 11828317. AN - SCOPUS:0036164451. VL - 123. SP - 389. EP - 391. JO - Journal of Thoracic and Cardiovascular Surgery. JF - Journal of Thoracic and Cardiovascular Surgery. SN - 0022-5223. IS - 2. ER - ...
This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with severe cGVHD develop BO, which portends a poor prognosis. Lung transplantation may be performed for severe refractory BO. In this group, 6 patients underwent bilateral lung transplantation and 1 underwent single lung transplantation. Explanted lung pathology confirmed BO in all patients. The median survival after lung transplantation in this group was 24 months. The authors conclude that lung transplantation is a possible therapeutic option for certain patients with severe therapy-refractory BO.. ...
TY - JOUR. T1 - Improved results of lung transplantation for patients with cystic fibrosis. AU - Egan, Thomas M.. AU - Detterbeck, Frank C.. AU - Mill, Michael R.. AU - Paradowski, Linda J.. AU - Lackner, Rudy P.. AU - Ogden, W. David. AU - Yankaskas, James R.. AU - Westerman, Jan H.. AU - Thompson, Jeanette T.. AU - Weiner, Meredith A.. AU - Cairns, Ellen L.. AU - Wilcox, Benson R.. PY - 1995/2. Y1 - 1995/2. N2 - Patients with cystic fibrosis pose particular challenges for lung transplantation surgeons. Earlier reports from North America centers suggested that patients with cystic fibrosis were greater risk for heart-lung or isolated lung transplantation than other patients with end-stage pulmonary disease. During a 3 1/2 year period, 44 patients with end-stage lung disease resulting from cystic fibrosis underwent double lung transplantation at this institution. During the same interval, 18 patients with cystic fibrosis, died while waiting for a double lung transplantation. The ages of the ...
TY - JOUR. T1 - Effects of inhaled nitric oxide following lung transplantation. AU - Yerebakan, Can. AU - Ugurlucan, Murat. AU - Bayraktar, Selcan. AU - Bethea, Brian T.. AU - Conte, John V.. PY - 2009/5/1. Y1 - 2009/5/1. N2 - Background: Lung transplantation offers an established therapeutic option for end-stage lung disease. It is associated with several complications, and early allograft failure is one of the most devastating among all. Different studies are focused on an attempt to minimize these complications, especially transplant failure. We aimed to evaluate the effects of inhaled nitric oxide (iNO) treatment in patients receiving lung transplantation. Methods: Nine patients (six female, three male; mean age 42.9 ± 15.8) requiring lung transplantation for end-stage pulmonary disease - chronic obstructive pulmonary disease (three patients), cystic fibrosis (three patients), scleroderma and systemic sclerosis (two patients), Eisenmengers syndrome (one patient), and treated with iNO were ...
Airway complications following lung transplantation remain a significant cause of morbidity and mortality. The management of bronchial complications in Bronchus Intermedius (BI) is challenging due to the location of right upper bronchus. The aim of this study was to analyze the results of BI Montgomery T-tube stent in a consecutive patients with lung transplantations. Between January 2007 and December 2010, 132 lung transplantations were performed at Foch Hospital, Suresnes, France. All the patients who had BI Montgomery T-tube after lung transplantation were included in this retrospective study. The demographic and interventional data and also complications were recorded. Out of 132 lung transplant recipients, 12 patients (9 male and 3 female) were entered into this study. The indications for lung transplantation were: cystic fibrosis 8 (67%), emphysema 3 (25%), and idiopathic pulmonary fibrosis 1 (8%). Most of the patients (83%) had bilateral lung transplantation. The mean interval between lung
Experience with cyclosporine in living-donor lobar lung transplantation.: Living-donor lobar lung transplantation is an alternative to conventional cadaveric lu
TY - JOUR. T1 - An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK. AU - Fisher, Andrew. AU - Andreasson, Anders. AU - Chrysos, Alexandros. AU - Lally, Joanne. AU - Mamasoula, Chrysovalanto. AU - Exley, Catherine. AU - Wilkinson, Jennifer. AU - Qian, Jessica. AU - Watson, Gillian. AU - Lewington, Oli. AU - Chadwick, Thomas. AU - McColl, Elaine. AU - Pearce, Mark. AU - Mann, Kay. AU - McMeekin, Nicola. AU - Vale, Luke. AU - Tsui, Steven. AU - Yonan, Nizar. AU - Simon, Andre. AU - Marczin, Nandor. AU - Mascaro, Jorge. AU - Dark, John. PY - 2016/11/1. Y1 - 2016/11/1. N2 - Background - Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. Objective - The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in ...
article{25205500-431b-46ab-9210-2bfbb4cda0fd, abstract = {,p,AIMS: The aims of this study were two-fold: to develop the concept analysis by Allvin et al. from lung recipients perspective of their post-transplant recovery process and to identify the recovery trajectories including critical junctions in the post-transplant recovery process after lung transplantation.,/p,,p,BACKGROUND: Lung transplantation is an established treatment for patients with end-stage lung disease. The recovery process after lung transplantation is very demanding. Today, patients are expected to play an active role in their own recovery but require ongoing support during the process.,/p,,p,DESIGN: A deductive, retrospective interview study using directed content analysis and Allvins recovery concept analysis.,/p,,p,METHOD: Fifteen adult lung transplant recipients who were due their 12-month follow-up were consecutively included and interviewed during 2015. Patients who were medically unstable or had difficulties ...
Background Many benefits and adverse effects of positioning are related to changes in ventilation and perfusion. A number of unique factors related to the allograft make the effects of positioning difficult to determine in single-lung transplant recipients.. • Objectives To determine the effect of 3 body positions (supine, lateral with allograft lung down, and lateral with native lung down) on oxygenation and blood flow in single-lung transplant recipients in the 24 hours immediately after surgery.. • Methods A quasi-experimental repeated-measures design with stratified assignment to 1 of 3 different sequencing patterns for turning group was used to study 15 transplant recipients, 9 with emphysema and 6 with fibrosis. Oxygenation, ventilation, and blood flow measures (heart rate, blood pressure) were assessed after each turn. The effect of ischemic reperfusion injury was also explored.. • Results The oxygenation, ventilation, and blood flow variables did not differ significantly across ...
Inhaled nitric oxide during anesthesia for bilateral single lung transplantation. Case report - Minerva Anestesiologica 1998 June;64(6):297-301 - Minerva Medica - Journals
TY - JOUR. T1 - Removal and repositioning of permanent expandable wire stents in bronchial airway stenosis after lung transplantation. AU - Sonett, J. R.. AU - Conte, John. AU - Orens, J.. AU - Krasna, M.. PY - 1998/4/29. Y1 - 1998/4/29. N2 - Significant airway stenosis occurs in 7% to 14% of lung transplant recipients. The use of permanent, nonadjustable, wire mesh stents can be of concern in the transplant recipient with nonmalignant stricture. We report the replacement and repositioning of an expandable wire mesh stent in a double lung transplantation with distal bronchial stenosis.. AB - Significant airway stenosis occurs in 7% to 14% of lung transplant recipients. The use of permanent, nonadjustable, wire mesh stents can be of concern in the transplant recipient with nonmalignant stricture. We report the replacement and repositioning of an expandable wire mesh stent in a double lung transplantation with distal bronchial stenosis.. UR - ...
Background: Lung transplantation is an important option to treat patients with advanced cystic fibrosis (CF) lung disease. The outcomes of a large UK cohort of CF lung transplantation recipients is reported.. Methods: Retrospective review of case notes and transplantation databases.. Results: 176 patients with CF underwent lung transplantation at our centre. The majority (168) had bilateral sequential lung transplantation. Median age at transplantation was 26 years. Diabetes was common pretransplantation (40%). Polymicrobial infection was common in individual recipients. A diverse range of pathogens were encountered, including the Burkholderia cepacia complex (BCC). The bronchial anastomotic complication rate was 2%. Pulmonary function (forced expiratory volume in 1 s % predicted) improved from a pretransplantation median of 0.8 l (21% predicted) to 2.95 l (78% predicted) at 1 year following transplantation. We noted an acute rejection rate of 41% within the first month. Our survival values were ...
TY - JOUR. T1 - Nitrite reduces acute lung injury and improves survival in a rat lung transplantation model. AU - Sugimoto, R.. AU - Okamoto, T.. AU - Nakao, A.. AU - Zhan, J.. AU - Wang, Y.. AU - Kohmoto, J.. AU - Tokita, D.. AU - Farver, C. F.. AU - Tarpey, M. M.. AU - Billiar, T. R.. AU - Gladwin, M. T.. AU - McCurry, K. R.. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2012/11. Y1 - 2012/11. N2 - Ischemia/reperfusion injury (IRI) is the most common cause of early mortality following lung transplantation (LTx). We hypothesized that nitrite, an endogenous source of nitric oxide (NO), may protect lung grafts from IRI. Rat lung grafts were stored in preservation solution at 4°C for 6 hours. Both grafts and recipients were treated with nitrite. Nitrite treatment was associated with significantly higher levels of tissue oxygenation, lower levels of cytokines and neutrophil/macrophage infiltration, lower myeloperoxidase activity, reduced oxidative injury and increased ...
Once a patient has been selected as a possible organ recipient, the process of waiting for a donor organ match begins. The donor organ must meet specific requirements for tissue match in order to reduce the chance of organ rejection. It is estimated that it takes an average of one to two years to receive a suitable donor lung, and the wait is made less predictable by the necessity for tissue match. Patients on a recipient list must be available and ready to come to the hospital immediately when a donor match is found, since the life of the lungs outside the body is brief. Single lung transplantation is performed via a standard thoracotomy (incision in the chest wall) with the patient under general anesthesia. Cardiopulmonary bypass (diversion of blood flow from the heart) is not always necessary for a single lung transplant. If bypass is necessary, it involves re-routing of the blood through tubes to a heart-lung bypass machine. Double lung transplantation involves implanting the lungs as two ...
Lung Transplantation may be suitable for those patients, physically eligible to undergo a major transplant operation.. In IPF patients, lung transplantation reduces the risk of death by 75% as compared with patients who remain on the waiting list.. Since the introduction of the lung allocation score (LAS), which prioritizes transplant candidates based on survival for lung transplantation in the USA.. Symptomatic patients with IPF younger than 65 years of age and with a body mass index (BMI) ≤ 26kg/m² should be referred for lung transplantation, but there are no clear data to guide the precise timing for LT.. Bilateral lung transplantation is superior to single lung transplantation in patients with IPF ...
Lung transplantation has become a therapeutic option for a number of end-stage pulmonary disorders. Lung transplant recipients experience more complications due to acute and chronic allograft rejection as compared to recipients of other solid organs. We postulated that the generation of TNF-alpha plays a significant role in the pathogenesis of acute lung allograft rejection. To test our hypothesis, we used a RT1-incompatible rat lung allograft model and demonstrated the time course, cellular source(s), and major compartment(s) of TNF production during the course of lung allograft rejection. This model allowed for immunogenetic standardization and reproducibility of lung allograft rejection across disparate major histocompatibility barriers. TNF production was characterized at the whole animal, organ, cellular, and molecular levels, and was found to be compartmentalized and expressed in a bimodal fashion from the lung allograft during lung allograft reimplantation and maximal rejection. Lung ...
Norihisa Shigemura, MD, PhD, has been appointed Surgical Director of Lung Failure, and Surgical Director of Lung Transplantation at Temple University Hospital (TUH), and Associate Professor of Surgery at the Lewis Katz School of Medicine at Temple University (LKSOM).. Dr. Shigemura earned his medical degree from Osaka University School of Medicine in Osaka, Japan. He completed a general surgery residency at Ohtemae General Hospital in Osaka, Japan, as well as cardiovascular surgery and thoracic surgery residencies at Osaka Prefectural Hospital in Osaka, Japan. In addition, Dr. Shigemura completed cardiothoracic surgery fellowships in Osaka, Japan; Hong Kong, China; and at University of Pittsburgh Medical Center (UMPC) in Pittsburgh, PA.. Dr. Shigemuras clinical and research interests include advanced lung failure/ end-stage lung disease; lung transplantation; minimally invasive thoracic surgery; extracorporeal circulatory support; artificial lungs; lung repair/regeneration; and organ ...
TY - JOUR. T1 - Effect of calcitriol on bone loss after cardiac or lung transplantation. AU - Sambrook, Philip. AU - Henderson, N. Kathy. AU - Keogh, Anne. AU - MacDonald, Peter. AU - Glanville, Allan. AU - Spratt, Phillip. AU - Bergin, Peter. AU - Ebeling, Peter. AU - Eisman, John. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Rapid bone loss after cardiac and lung transplantation results in an increased risk of osteoporotic fracture. This study examined the efficacy of treatment with calcitriol (1,25-dihydroxyvitamin D3) in preventing bone loss in patients undergoing cardiac or lung transplantation. In this 2-year double-blind, stratified study, 65 patients undergoing cardiac or single lung transplantation were randomly allocated to receive either placebo or calcitriol (0.5-0.75 μg/day), the latter for either 12 months or 24 months. All patients received 600 mg calcium/day. Bone mineral density (BMD) was measured every 6 months for 2 years by dual-energy X-ray absorptiometry. There was no significant ...
Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically C4a and C5a - is associated with PGD, and an increase in C3a and C5a levels is associated with mortality, independent of PGD. However, serum levels appear to be high at baseline post-lung transplantation (LTx); and hence, make it harder to distinguish patients at risk. Given that PGD manifests as an acute lung injury, we hypothesized that local complement activation would help identify those who go on to develop PGD post-LTx.. *Methods: Bronchoalveolar lavage (BAL) specimens were obtained from recipients at 2 and 24h post-LTx. PGD was scored based on the consensus definition at 24, 48 and 72h post-LTx by an investigator blinded to the results. Complement activation proteins were measured using ELISA. Specifically, levels of C4d, indicating classical/lectin pathway activation and soluble C5b-9 (sC5b-9), a marker of ...
Michael W. Sims, Michael F. Beers, Vivek N. Ahya, Steven M. Kawut, Karen D. Sims, David J. Lederer, Scott M. Palmer, Keith Wille, Vibha N. Lama, Pali D. Shah, Jonathan B. Orens, Sangeeta Bhorade, Maria Crespo, Ann Weinacker, Ejigayehu Demissie, Scarlett Bellamy, Jason D. Christie, Lorraine B. Ware ...
Home , International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung ...
TY - JOUR. T1 - cAMP-mediated vascular protection in an orthotopic rat lung transplant model. T2 - Insights into the mechanism of action of prostaglandin E1 to improve lung preservation. AU - Naka, Yoshifumi. AU - Roy, Dilip K.. AU - Liao, Hui. AU - Chowdhury, Nepal C.. AU - Michler, Robert E.. AU - Oz, Mehmet C.. AU - Pinsky, David J.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Prostaglandin E1 (PGE1) is often added to the donor pulmonary flush solution to enhance clinical lung preservation for transplantation. Although PGE1 is thought to act as a pulmonary vasodilator during the harvest period, the precise mechanism(s) of action whereby PGE1 enhances lung preservation is unknown. Because cAMP levels decline in endothelial and vascular smooth muscle cells exposed to hypoxia, we hypothesized that a PGE1-mediated increase in cAMP levels within the preserved lungs might improve pulmonary vascular homeostasis following lung transplantation. Rat lungs demonstrated a time-dependent decline in cAMP levels ...
THURSDAY, June 11, 2020 (HealthDay News) -- A young COVID-19 survivor received a double-lung transplant to save her life in whats believed to be the first such surgery in the United States, Northwestern Medicine doctors report.. Following her infection, the Hispanic woman in her 20s suffered irreversible lung damage and had to be put on a life-support machine that does the work of the heart and lungs.. A lung transplant was her only chance for survival, said Dr. Ankit Bharat, surgical director of Northwestern Medicines lung transplant program.. We are one of the first health systems to successfully perform a lung transplant on a patient recovering from COVID-19. We want other transplant centers to know that while the transplant procedure in these patients is quite technically challenging, it can be done safely, and it offers the terminally ill COVID-19 patient another option for survival, Bharat said in a Northwestern news release.. Before the patient could be put on the transplant ...
TY - JOUR. T1 - Lung transplantation. T2 - Chronic allograft dysfunction and establishing immune tolerance. AU - Gracon, Adam S.A.. AU - Wilkes, David S.. PY - 2014/8. Y1 - 2014/8. N2 - Despite significant medical advances since the advent of lung transplantation, improvements in long-term survival have been largely unrealized. Chronic lung allograft dysfunction, in particular obliterative bronchiolitis, is the primary limiting factor. The predominant etiology of obliterative bronchiolitis involves the recipients innate and adaptive immune response to the transplanted allograft. Current therapeutic strategies have failed to provide a definitive treatment paradigm to improve long-term outcomes. Inducing immune tolerance is an emerging therapeutic strategy that abrogates allograft rejection, avoids immunosuppression, and improves long-term graft function. The aim of this review is to discuss the key immunologic components of obliterative bronchiolitis, describe the state of establishing immune ...
Background Right-heart-catheterization and transthoracic echocardiography are routine tests to measure pulmonary artery systolic pressure among lung transplantation candidates. Echocardiography may be as accurate as right-heart-catheterization, without the inherent risks of an invasive test. Methods We examined the correlation between pulmonary pressures estimated by echocardiography versus right-heart-catheterization among lung transplantation candidates and their correlation to measurements during lung transplantation. Our cohort included all lung transplantation candidates during 1997 through 2004 who initially underwent pulmonary pressure evaluation by right-heart-catheterization and echocardiography, as well as measurements during lung transplantation. Results Of the 106 candidates, evaluation by transthoracic echocardiography was possible in 79 (74.5%). Median pulmonary systolic pressures by right-heart-catheterization was 44.0 [33.2-50.0] mm Hg and by echocardiography 40.0 [32.5-51.5] mm ...
Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust...
Figure S1: Low donor lung SP-A mRNA-level associates with decreased survival. The graph shows the survival curves for recipients of double lung transplant excluding patient with ILD. This ad hoc analysis was to address the possible selection bias that is shown in Table S1 with greater percentage of ILD and single lung transplant in the study cohort. Lung transplant patients that received lung allografts with low levels of SP-A mRNA expression prior to implantation had significantly reduced survival. The number of patients in each group is indicated in brackets. The x-axis represents the cumulative survival. Circles indicate the censored patients within the analysis. ...
CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.: Studies on persistent viral infections demonstrate t
Targeting viral proteins early during infection may limit exacerbation of human cytomegalovirus infection. The viral chemokine-receptor homologue US28 interferes with leukocyte trafficking and, possibly, viral replication. Because US28 molecules are abundant on the surface of infected cells, this homologue is a potential target for antiviral therapy. To assess the relationship between US28 and disease activity, we measured, by quantitative reverse-transcription polymerase chain reaction, the levels of US28 and immediate-early (IE) 1 gene transcripts in the blood of lung-transplant recipients. We found that, during primary and secondary infection, the IE1 and US28 genes have early transcription kinetics and are expressed at similar levels. This may render US28 an attractive target for antiviral therapy ...
Researchers have shown for the first time that lung transplant patients in Europe who live on or near busy roads with high levels of air pollution are more likely to die or to experience chronic organ rejection, than those living in less polluted areas.. Dr David Ruttens, from the University of Leuven (Belgium) told the European Respiratory Societys International Congress today (29 September, 2015) that the risk of dying increased by 10% for patients living in an area where air pollution was above World Health Organization (WHO) recommended maximum levels, compared with patients living in areas with lower levels of pollution. However, this increased risk was not seen in lung transplant patients who were taking a class of antibiotics called macrolides, which include azithromycin and clarithromycin.. WHO estimates that 3.7 million people worldwide die prematurely every year as a result of exposure to small particulate matter measuring between 2.5-10 micrometers in diameter (known as PM10). Ten ...
TY - JOUR. T1 - Tuberculosis in lung transplant recipients. AU - Bravo, Carlos. AU - Roldán, Juan. AU - Roman, Antonio. AU - DeGrada, Javier. AU - Majo, Joaquim. AU - Guerra, Javier. AU - Monforte, Víctor. AU - Vidal, Rafael. AU - Morell, Ferran. PY - 2005/1/15. Y1 - 2005/1/15. N2 - Background. Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define the incidence, clinical presentation, and course of tuberculosis in a cohort of lung transplant patients at a single center in Spain. Methods. Between 1990 and 2002, cutaneous delayed-type hypersensitivity testing and pathologic and microbiologic study of explanted lungs were conducted in 187 lung transplant patients. Serial bronchoscopies with transbronchial biopsy and bronchioalveolar lavage were ...
Chronic rejection significantly limits long-term success of solid organ transplantation. De novo donor-specific antibodies (DSAs) to mismatched donor human leukocyte antigen after human lung transplantation predispose lung grafts to chronic rejection. We sought to delineate mediators and mechanisms of DSA pathogenesis and to define early inflammatory events that trigger chronic rejection in lung transplant recipients and obliterative airway disease, a correlate of human chronic rejection, in mouse. Induction of transcription factor zinc finger and BTB domain containing protein 7a (Zbtb7a) was an early response critical in the DSA-induced chronic rejection. A cohort of human lung transplant recipients who developed DSA and chronic rejection demonstrated greater Zbtb7a expression long before clinical diagnosis of chronic rejection compared to nonrejecting lung transplant recipients with stable pulmonary function. Expression of DSA-induced Zbtb7a was restricted to alveolar macrophages (AMs), and ...
Blatter JA, Noyes B, Sweet SC. Pediatric lung transplantation. In: Wilmott RW, Deterding R, Li A, et al. eds. Kendigs Disorders of the Respiratory Tract in Children. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 67.. Brown LM, Puri V, Patterson GA. Lung transplantation. In: Sellke FW, del Nido PJ, Swanson SJ, eds. Sabiston and Spencer Surgery of the Chest. 9th ed. Philadelphia, PA: Elsevier; 2016:chap 14.. Chandrashekaran S, Emtiazjoo A, Salgado JC. Intensive care unit management of lung transplant patients. In: Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink MP, eds. Textbook of Critical Care. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 158.. Kliegman RM, Stanton BF, St. Geme JW, Schor NF. Pediatric heart and heart-lung transplantation. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 443.. Kotloff RM, Keshavjee S. Lung transplantation. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray & Nadels ...
BackgroundGastroesophageal reflux disease (GERD) is common in patients with end-stage lung disease (ESLD). GERD may cause obliterative bronchiolitis after lung
Pulmonary rehabilitation (PR) is a cornerstone of treatment following lung transplantation (LTx). The aim of this study was to observe the influence of a prolonged postsurgical clinical course on success of a 3-week inpatient PR. LTx recipients were divided according to their clinical course defined …
TY - JOUR. T1 - The registry of the international society for heart and lung transplantation. T2 - Twenty-eighth adult lung and heart-lung transplant report-2011. AU - Christie, Jason D.. AU - Edwards, Leah B.. AU - Kucheryavaya, Anna Y.. AU - Benden, Christian. AU - Dobbels, Fabienne. AU - Kirk, Richard. AU - Rahmel, Axel O.. AU - Stehlik, Josef. AU - Hertz, Marshall I.. PY - 2011/10/1. Y1 - 2011/10/1. UR - UR - U2 - 10.1016/j.healun.2011.08.004. DO - 10.1016/j.healun.2011.08.004. M3 - Article. C2 - 21962018. AN - SCOPUS:80053316665. VL - 30. SP - 1104. EP - 1122. JO - Journal of Heart and Lung Transplantation. JF - Journal of Heart and Lung Transplantation. SN - 1053-2498. IS - 10. ER - ...
TY - JOUR. T1 - The Registry of the International Society for Heart and Lung Transplantation. T2 - Twenty-seventh official adult lung and heart-lung transplant report2010. AU - Christie, Jason D.. AU - Edwards, Leah B.. AU - Kucheryavaya, Anna Y.. AU - Aurora, Paul. AU - Dobbels, Fabienne. AU - Kirk, Richard. AU - Rahmel, Axel O.. AU - Stehlik, Josef. AU - Hertz, Marshall I.. PY - 2010/10. Y1 - 2010/10. UR - UR - U2 - 10.1016/j.healun.2010.08.004. DO - 10.1016/j.healun.2010.08.004. M3 - Article. C2 - 20870165. AN - SCOPUS:77957229065. VL - 29. SP - 1104. EP - 1118. JO - Journal of Heart and Lung Transplantation. JF - Journal of Heart and Lung Transplantation. SN - 1053-2498. IS - 10. ER - ...
Living-donor lobar lung transplantation (LDLLT) was developed to deal with the severe shortage of brain dead door for patients who would not survive the long waiting period. In standard LDLLT, right and left lower lobes removed from two healthy donors are implanted into a recipient after right and left pneumonectomies using cardiopulmonary bypass (CPB). The number of LDLLT has decreased in the USA due to the recent change in allocation system for cadaveric donor lungs. For the past several years, most of the reports on LDLLT have been from Japan, where the average waiting time for a cadaveric lung is exceeding 800 days. LDLLT has been performed both for adult and pediatric patients suffering from various end-stage lung diseases including restrictive, obstructive, vascular and infectious lung diseases. Since only two lobes are implanted, size matching is a very important issue. Functional size matching by measuring donor pulmonary function and anatomical size matching by three-dimensional ...
The lung allocation score (LAS) is a numerical value used by the United Network for Organ Sharing (UNOS) to assign relative priority for distributing donated lungs for transplantation within the United States. The lung allocation score takes into account various measures of a patients health in order to direct donated organs towards the patients who would best benefit from a lung transplant. The LAS system replaces the older method within the United States of allocating donated lungs strictly on a first-come, first-served basis, according to blood type compatibility and distance from the donor hospital. The older method is still used for patients under the age of 12. The LAS system is still being evaluated and revised.[1] The reason for this continuing analysis is the need to balance on one hand the desire to help those patients in direct need, versus the statistical likelihood of the patient to survive the procedure, as well as the post-operative risks of infection and transplant rejection.[2] ...
End-stage lung disease (ESLD) is a frequent cause of death. What are the differences in the supports needed by caregivers of individuals with ESLD at end of life versus other life-limiting diagnoses? The South Australian Health Omnibus is an annual, random, face-to-face, cross-sectional survey. In 2002, 2003 and 2005-2007, respondents were asked a range of questions about end-of-life care; there were approximately 3000 survey participants annually (participation rate 77.9%). Responses were standardised for the whole population. The families and friends who cared for someone with ESLD were the focus of this analysis. In addition to describing caring, respondents reported additional support that would have been helpful. Of 1504 deaths reported, 145 (9.6%) were due to ESLD. The ESLD cohort were older than those with other expected causes of death (| 65 years of age; 92.6% versus 70.6%; p | 0.0001) and were less likely to access specialised palliative care services (38.4% versus 61.9%; p | 0.0001). For
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BACKGROUND: In an era of increasing ex vivo lung perfusion (EVLP) use, it remains important to describe what outcomes can be achieved without EVLP, by taking an aggressive approach to donor use to maximize lung transplantation. METHODS: Data for all lung transplant donor referrals to the Alfred Hospital in Melbourne, Australia were collected for 2012 to 2013. Donor variables were analyzed and calculated into a previously validated lung donor score. Lung transplant recipient outcome data included the following: primary graft dysfunction; duration of mechanical ventilation; need for cardiopulmonary bypass extracorporeal membrane oxygenation; intensive care and hospital length of stay; 30-day, 1-year, and 3- to 4-year survival rates; rates of acute rejection and chronic lung allograft dysfunction; and peak and 12-month lung function (forced expiratory volume in 1 second ...
Lung transplant survival is usually limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. CD4, T-cells, lung transplantation, Th17 cells, STAT3, T-cells Introduction Lung transplantation is usually a useful therapeutic option for patients with end-stage lung diseases. The major obstacle limiting lung transplant survival and function is usually chronic lung allograft dysfunction (CLAD), Cichoric Acid IC50 with one of the major manifestations being obliterative bronchiolitis (OB) with fibrous obliteration of the airways (1). Progressive air passage injury mediated by ongoing alloimmune and nonalloimmune responses to the lung allograft is usually thought to be the precursor of subsequent graft CALML3 fibrosis (2). OB/BOS remains one of the major limitations to long term success of lung transplant with approximately 50% of lung transplant recipients affected by 5 years (3). Recently, IL-17 and T helper 17 (Th17) cells have been linked to OB/BOS development ...
Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS). Survey of 278 recipients who underwent LTx. The endpoint used was BOS (BOS grade ≥ 2), death or Re-lung transplantation (Re-LTx) assessed by competing risk regression analyses. The incidence of BOS grade ≥ 2 among double LTx (DLTx) recipients was 16 ± 3% at 5 years, 30 ± 4% at 10 years, and 37 ± 5% at 20 years, compared to single LTx (SLTx) recipients whose corresponding incidence of BOS grade ≥ 2 was 11 ± 3%, 20 ± 4%, and 24 ± 5% at 5, 10, and 20 years, respectively (p | 0. 05). The incidence of BOS grade ≥ 2 by major indications ranked in descending order: other, PF, CF, COPD, PH and AAT1 (p | 0. 05). The mortality rate by major indication ranked in descending order: COPD, PH, AAT1, PF, Other and CF (p | 0. 05). No differences were seen in the incidence of BOS grade ≥ 2 regarding type of transplant, however, DLTx recipients showed a better chance of survival despite developing BOS
Bronchiolitis obliterans syndrome (BOS) is a form of chronic lung allograft dysfunction that affects a majority of lung transplant recipients and is the primary factor limiting long-term transplant survival. It is characterized by progressive airflow obstruction resulting in acute rejection of the graft, followed by infections, or other coexistent condition.. It is an uncommon respiratory disease characterized by fixed airway obstruction, where the bronchioles in the lung become narrowed or blocked by fibrous tissue. The disease is disabling and can be potentially severe. It may be caused occupationally by accidental, acute, high concentration exposure to industrial gases, such as nitrogen dioxide etc.. Bronchiolitis obliterans can also be associated with rheumatoid arthritis and graft-versus-host disease following a lung or hematopoietic cell transplantation. Exposure to certain food flavoring agents, notably the buttery food flavoring agent diacetyl, with the development of bronchiolitis ...
TY - JOUR. T1 - Clinical risk factors for primary graft dysfunction after lung transplantation. AU - Diamond, Joshua M.. AU - Lee, James C.. AU - Kawut, Steven M.. AU - Shah, Rupal J.. AU - Localio, A. Russell. AU - Bellamy, Scarlett L.. AU - Lederer, David J.. AU - Cantu, Edward. AU - Kohl, Benjamin A.. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta M.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Sonett, Joshua. AU - Wille, Keith. AU - Orens, Jonathan. AU - Shah, Ashish S.. AU - Weinacker, Ann. AU - Arcasoy, Selim. AU - Shah, Pali D.. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Palmer, Scott M.. AU - Christie, Jason D.. PY - 2013/3/1. Y1 - 2013/3/1. N2 - Rationale: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. Objectives: We sought to identify donor, recipient, and perioperative risk factors for PGD. Methods: Weperformeda 10-center prospective ...
In 2002 the International Society for Heart and Lung Transplantation (ISHLT) modified the 1993 criteria for the bronchiolitis obliterans syndrome (BOS, obliterative bronchiolitis).
TY - JOUR. T1 - Endovascular management of pseudoaneurysm formation in the ascending aorta following lung transplantation. AU - Joyce, David L.. AU - Singh, Steve K.. AU - Mallidi, Hari R.. AU - Dake, Michael D.. PY - 2012. Y1 - 2012. N2 - Purpose: To demonstrate the role of endovascular approaches to the ascending aorta in the post-transplant context. Case Reports: Three patients (2 women and 1 man aged 52, 68, and 43 years, respectively) developed pseudoaneurysm of the ascending aorta following thoracic organ transplantation. Due to the prohibitive risk of open surgery in each case, an endovascular repair of the ascending aorta was performed, with implantation of 1 to 3 stent-grafts to span the lesions. Follow-up imaging demonstrated complete exclusion of the pseudoaneurysms, with excellent outcomes at 4 months, 6 months, and 3 years. Conclusion: Stent-grafting of the ascending aorta represents a viable approach to pseudoaneurysm in the post-transplant setting.. AB - Purpose: To demonstrate ...
TY - JOUR. T1 - Post-operative Infections in Cystic Fibrosis and Non-Cystic Fibrosis Patients After Lung Transplantation. AU - Bonvillain, Ryan W.. AU - Valentine, Vincent G.. AU - Lombard, Gisele. AU - LaPlace, Stephanie. AU - Dhillon, Gundeep. AU - Wang, Guoshun. PY - 2007/9. Y1 - 2007/9. N2 - Background: Cystic fibrosis (CF) lung disease is the major cause of mortality in CF patients. Lung transplantation remains a valid therapeutic option. It is unknown whether CF patients receiving healthy lungs have an equal susceptibility to infections when compared with non-CF lung transplant patients. Herein we present the largest analyses to date of the post-operative infection profiles of 60 CF and 60 non-CF lung transplant patients. Methods: Bilateral allogeneic lung transplantations and post-transplant management were performed according to standard clinical procedures. Post-operative infections were diagnosed by conventional methods based on clinical symptoms and laboratory cultures. Results: Sixty ...
TY - JOUR. T1 - Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. AU - Palmer, S. M.. AU - Klimecki, W.. AU - Yu, L.. AU - Reinsmoen, N. L.. AU - Snyder, L. D.. AU - Ganous, T. M.. AU - Burch, L.. AU - Schwartz, D. A.. PY - 2007/3. Y1 - 2007/3. N2 - We have developed the hypothesis that genetic polymorphisms which alter the expression or function of innate immune receptors contribute to the marked interindividual differences in the onset and severity of lung transplant rejection. In this analysis, we considered the effects of a common promotor polymorphism of the lipopolysaccharide receptor CD14 associated with increased transcriptional activity upon the development of posttransplant rejection and graft survival. Genotyping was performed in 226 lung transplant recipients well characterized with regards to clinical outcomes. An earlier onset of acute rejection, bronchiolitis obliterans syndrome (BOS) and worse posttransplant ...
TY - JOUR. T1 - Reconstruction of pulmonary artery with donor aorta and autopericardium in lung transplantation. AU - Noda, Masafumi. AU - Okada, Yoshinori. AU - Saiki, Yoshikatsu. AU - Sado, Tetsu. AU - Hoshikawa, Yasushi. AU - Endo, Chiaki. AU - Sakurada, Akira. AU - Maeda, Sumiko. AU - Oishi, Hisashi. AU - Kondo, Takashi. PY - 2013/7/1. Y1 - 2013/7/1. N2 - A 44-year-old man with Eisenmengers syndrome due to ventricular septal defect (VSD) was listed for lung transplantation. The patients condition was complicated by a giant pulmonary artery (PA) aneurysm. Concurrent VSD closure and total reconstruction of the recipient PA with the donor aorta were planned. When the patient underwent bilateral lung transplantation, the aortic graft obtained turned out to be too short to complete the reconstruction. A PA graft made of the recipients pericardium was successfully interposed between the donors PA and the donors aortic graft.. AB - A 44-year-old man with Eisenmengers syndrome due to ...
TY - JOUR. T1 - A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. AU - Shah, Rupal J.. AU - Bellamy, Scarlett L.. AU - Localio, A. Russell. AU - Wickersham, Nancy. AU - Diamond, Joshua M.. AU - Weinacker, Ann. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta. AU - Belperio, John A.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Kawut, Steven M.. AU - Wille, Keith M.. AU - Lederer, David J.. AU - Lee, James C.. AU - Palmer, Scott M.. AU - Orens, Jonathan. AU - Reynolds, John. AU - Shah, Ashish. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Christie, Jason D.. PY - 2012/9. Y1 - 2012/9. N2 - Background: We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research. Methods: Biomarkers reflecting lung epithelial injury (soluble receptor for advance glycation end products [sRAGE] and surfactant protein-D [SP-D]), coagulation cascade (plasminogen ...
TY - JOUR. T1 - Does reperfusion injury still cause significant mortality after lung transplantation?. AU - Ailawadi, Gorav. AU - Lau, Christine L.. AU - Smith, Philip W.. AU - Swenson, Brian R.. AU - Hennessy, Sara A.. AU - Kuhn, Courtney J.. AU - Fedoruk, Lynn M.. AU - Kozower, Benjamin D.. AU - Kron, Irving L.. AU - Jones, David R.. N1 - Funding Information: Supported in part through National Institutes of Health Cardiovascular Surgery Research Training grant T32 HL007849 (to PWS). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2009/3. Y1 - 2009/3. N2 - Objectives: Severe reperfusion injury after lung transplantation has mortality rates approaching 40%. The purpose of this investigation was to identify whether our improved 1-year survival after lung transplantation is related to a change in reperfusion injury. Methods: We reported in March 2000 that early institution of extracorporeal membrane oxygenation can improve lung transplantation survival. The records of ...
Implementation of an evidence-based guideline for managing respiratory and hemodynamic status is feasible and safe and was associated with reduction in severity of primary graft dysfunction. Further studies are required to determine whether such a guideline would lead to a consistent reduction in severity of primary graft dysfunction at other institutions. Creation of a protocol for postoperative care provides a template for further studies of novel therapies or management strategies for primary graft dysfunction ...
The St Vincents Hospital transplant program is one of the largest and longest running programs in Australia with survival rates which exceed that of the international figures. The first heart transplant in Australia was performed by Dr Harry Windsor at St Vincents Hospital in 1968. However, it was not until 1984 that the National Heart Transplant Program was commenced by Dr Victor Chang and the second heart transplant was carried out eventually leading to the first heart-lung transplant in 1986. It was only natural that the heart transplantation program would soon be followed by the development of a lung transplantation program. This milestone was reached in 1990 when the first single lung transplant in Australia was performed at St Vincents Hospital and the program has since expanded to include bilateral lung transplantation. The transplant unit also runs a mechanical heart device program which can offer patients waiting for a donor to become available an improved quality of life and ...
TY - JOUR. T1 - Registry of the International Society for Heart and Lung Transplantation. T2 - Eleventh Official Pediatric Heart Transplantation Report-2008. AU - Kirk, Richard. AU - Edwards, Leah B.. AU - Aurora, Paul. AU - Taylor, David O.. AU - Christie, Jason. AU - Dobbels, Fabienne. AU - Kucheryavaya, Anna Y.. AU - Rahmel, Axel O.. AU - Hertz, Marshall I.. PY - 2008/9/1. Y1 - 2008/9/1. UR - UR - U2 - 10.1016/j.healun.2008.06.016. DO - 10.1016/j.healun.2008.06.016. M3 - Article. C2 - 18765188. AN - SCOPUS:50249105267. VL - 27. SP - 970. EP - 977. JO - Journal of Heart and Lung Transplantation. JF - Journal of Heart and Lung Transplantation. SN - 1053-2498. IS - 9. ER - ...
Traffic-related air pollution, as estimated by the proximity of the home to a major road, is a major risk factor for BOS and mortality after lung transplantation. The risk was present in either a dichotomous or a continuous analysis, and was not affected by adjustments for relevant covariables. Indicators of pulmonary (BAL neutrophils, IL-6) and systemic (plasma CRP) inflammation, which are probably involved in the onset of BOS, were also associated with proximity to traffic.. The strengths of our study include the relatively large lung transplant population from a single centre and the statistically robust associations. The statistical significance of our observations follows in part from the high incidence of BOS and mortality. The robustness of the associations is apparent from the fact that inclusion of relevant potential confounders, ranging from SES, transplantation-related characteristics to active smoking, tended to increase the risk estimates.18. Many other authors have estimated ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
Paraquat is a water soluble quaternary ammonium derivative, poorly absorbed by the oral route (5-10%) and unbound to plasma proteins. Peak plasma concentrations are reached within 1-4 hours and decrease rapidly thereafter as the compound is taken up by the tissues and cleared by the kidney.2 In our case paraquat was undetectable in plasma obtained four days after the start of gastrointestinal symptoms whereas high levels were found on lung and muscle samples taken as late as nine weeks after herbicide ingestion. Indeed, paraquat is actively concentrated in alveolar pneumocytes and skeletal muscles. The acute pulmonary lesions have been attributed to the formation of oxygen derived free radicals and lipid peroxidation products whereas activation of resident macrophages are implicated in lung fibrosis.3 All pharmacological treatments including free radical scavengers, iron chelators, cochicine or corticoids are of unproven value, but encouraging results have recently been reported with a ...
TY - JOUR. T1 - Pirfenidone alleviates lung ischemia-reperfusion injury in a rat model. AU - Saito, Masao. AU - Chen-Yoshikawa, Toyofumi F.. AU - Suetsugu, Kimitaka. AU - Okabe, Ryo. AU - Takahagi, Akihiro. AU - Masuda, Satohiro. AU - Date, Hiroshi. PY - 2019/7. Y1 - 2019/7. N2 - Objective: Lung ischemia-reperfusion injury is among the complications seen after lung transplantation, resulting in morbidity and mortality. Pirfenidone, an antifibrotic agent for the treatment of idiopathic pulmonary fibrosis, is reported to have cytoprotective properties in various disease models. The purpose of this study was to investigate the effect of pirfenidone on lung ischemia-reperfusion injury. Methods: Male Lewis rats (260-290 g) were divided into 3 groups: sham group (n = 5), warm ischemia (WI) group (n = 10), and WI plus pirfenidone (WI+PFD) group (n = 10). The sham group underwent 210 minutes of perfusion without ischemia. The WI and WI+PFD groups underwent 90 minutes of warm ischemia and 120 minutes of ...
Now in its 18th year of continuous publication, The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential clinical information about the rapidly evolving field of intrathoracic transplantation, support, and replacement. Peer-reviewed articles cover topics that include: assist devices and artificial hearts; diagnosis and treatment of complications; immunosuppressive therapies; new techniques in noninvasive diagnosis of rejection; outcome analyses; preoperative and postoperative evaluation; socioeconomic and ethical aspects of transplantation.. The journals scope also addresses all aspects of advanced diseases of native thoracic organs, and includes articles with new insights into the immunology, pathogenesis, diagnosis, and management of heart failure and advanced lung disease. In addition, the journal has expanded its coverage in the rapidly maturing field of nontransplantation cardiac ...
Respiratory viral infections can cause severe pneumonia in lung transplant recipients as well are associated with acute rejection and long-term morbidity with bronchiolitis obliterans syndrome. There are no specific antiviral options for the majority of respiratory viruses. DAS181 is a novel sialidase fusion protein and is administered by inhalation. The authors describe the use of this new antiviral in a lung transplant patient with parainfluenza virus infection requiring ICU admission. The authors obtained this drug under an emergency investigational new drug application. The case report describes clinical and virologic improvement with use of this medication, which was also well-tolerated. Newer therapies for respiratory virus infections are a welcome addition especially for transplant patients where disease is severe and options are limited.. ...
TY - JOUR. T1 - Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. AU - Shaver, Ciara M.. AU - Wickersham, Nancy. AU - McNeil, J. Brennan. AU - Nagata, Hiromasa. AU - Sills, Gillian. AU - Kuck, Jamie L.. AU - Janz, David R.. AU - Bastarache, Julie A.. AU - Ware, Lorraine B.. PY - 2017/9/1. Y1 - 2017/9/1. N2 - RATIONALE: Cell-free hemoglobin (CFH) is a potent oxidant associated with poor clinical outcomes in a variety of clinical settings. Recent studies suggest that acetaminophen (APAP), a specific hemoprotein reductant, can abrogate CFH-mediated oxidative injury and organ dysfunction. Preoperative plasma CFH levels are independently associated with primary graft dysfunction (PGD) after lung transplant ( 1 ).OBJECTIVES: Our objectives were to determine whether CFH would increase lung vascular permeability in the isolated perfused human lung and whether APAP would limit these effects.METHODS: Human lungs ...
The development of bronchiolitis obliterans in the allograft lung does not necessarily mean that it is due to immunologic activity. Numerous causes of small airway scarring have been recognized in lung transplant and non-transplant patients. Particularly relevant to the lung allograft recipient is the role of infection. Numerous infectious agents (to which the immunocompromised lung recipient is exposed) have been documented to cause bronchiolitis obliterans. These include many bacterial infections, viral infections, and some atypical organisms, including mycoplasma and chlamydia. In our practice, if we note histologic OB after a non-rejection related inflammatory process, we are certain to note this etiology in our pathology reports so that patients are not treated as for rejection induced OB. Second the development of acute harvest (ischemic) injury to the lung parenchyma has been associated with airway and interstitial scarring. This is particularly relevant in individuals who experience ...
During the last 20 years, there has been a shift away from combined heart-lung transplantation (HLT) in favor of bilateral lung transplantation. This paradigm shift allowed for the donor heart to be t
TY - JOUR. T1 - Long-term lung preservation with the PAF antagonist BN 52021. AU - Conte, John. AU - Katz, Nevin M.. AU - Wallace, Robert B.. AU - Foegh, Marie L.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - Platelet activating factor (PAF, l-alkyl-2(R)-acetyl- glycero-3-phosphorylcholine) is a phospholipid that is released by a variety of cells. The similarity between the pathophysiological effects of PAF and posttrans-plant pulmonary dysfunction led to an evaluation of a PAF antagonist as an adjunct to lung preservation. The ginkgolide B, BN 52021, was selected as the PAF antagonist to be studied because of the large data base available on this compound. BN 52021 was given to the donor and recipient (10 mg/kg i.v.) prior to harvest and transplantation and was included in 1 L of preservation solution (10 mg/kg) used for flushing the pulmonary artery and for storage. Left single-lung transplantation was performed following a 22-hr preservation period at 10°C. Arterial oxygen tension (pO2), pulmonary ...
Chronic allograft dysfunction in form of bronchiolitis obliterans is the most important hurdle to improved longterm survival after clinical lung transplantation to date. Recently, it was observed that the progression of bronchiolitis obliterans in lung transplant recipients might be inhibited by macrolide antibiotics. The authors therefore tested whether macrolide therapy can attenuate fibrous obliteration of airways in an animal model of bronchiolitis obliterans. Rats with heterotopic tracheal allografts were treated intraperitoneally with clarithromycin and compared to untreated transplanted animals with respect to allograft histology and expression of selected cytokines. At day 21 after transplantation, the tracheal allografts of treated animals were free of fibrous material or partially occluded dependent of clarithromycin dosage. Untreated animals had completely obliterated allografts. In treated animals, tumor necrosis factor alpha (TNF-alpha) was down-regulated early (5 days) and late (21 ...
Birch, Jodie, Sunny, Syba, Hester, Katy, Parry, Gareth, Gould, F. Kate, Dark, John, Clark, Stephen, Meachery, Gerard, Lordan, James, Fisher, Andrew, Corris, Paul and De Soyza, Anthony (2018) Outcomes of lung transplantation in adults with bronchiectasis. BMC Pulmonary Medicine, 18. ISSN 1471-2466 Sithamparanathan, Sasiharan, Thirugnanasothy, Logan, Clark, Stephen, Dark, John, Fisher, Andrew, Gould, Kate, Hasan, Asif, Lordan, James, Meachery, Gerard, Parry, Gareth and Corris, Paul (2016) Observational study of lung transplant recipients surviving 20 years. Respiratory Medicine, 117. pp. 103-108. ISSN 0954-6111 Ong, Lay Ping, Thompson, Emily, Sachdeva, Ashwin, Ramesh, B. C., Muse, Hazel, Wallace, Kirstie, Parry, Gareth and Clark, Stephen (2016) Allogeneic blood transfusion in bilateral lung transplantation: impact on early function and mortality. European Journal of Cardio-Thoracic Surgery, 49 (2). pp. 668-674. ISSN 1010-7940 Ong, Lay Ping, Sachdeva, Ashwin, Ramesh, Bandigowdanapalya Channaiah, ...
Pulmonary hypertension is one of the indications for lung transplantation. Recent advances on medical management of the disease have dramatically decreased the number of patients who required lung transplantation. In reported series, single or double lung transplantation have been successfully undertaken by many transplant centers. In patients, whose cardiac functions are irreversibly damaged heart-lung transplantation remains as an only option for long term survival. Transplantation should only be considered in those patients who are having optimal medical support and relatively good condition for a major operation.
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2017 The Authors. Background: Extended criteria donor lungs deemed unsuitable for immediate transplantation can be reconditioned using ex vivo lung perfusion (EVLP). Objective identification of which donor lungs can be successfully reconditioned and will function well post-operatively has not been established. This study assessed the predictive value of markers of inflammation and tissue injury in donor lungs undergoing EVLP as part of the DEVELOP-UK study. Methods: Longitudinal samples of perfusate, bronchoalveolar lavage, and tissue from 42 human donor lungs undergoing clinical EVLP assessments were analyzed for markers of inflammation and tissue injury. Levels were compared according to EVLP success and post-transplant outcomes. Neutrophil adhesion to human pulmonary microvascular endothelial cells (HPMECs) conditioned with perfusates from EVLP assessments was investigated on a microfluidic platform. Results: The most effective markers to differentiate between in-hospital survival and ...
Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and morta...
TY - JOUR. T1 - Increased levels of circulating nitrates and impaired endothelium- mediated vasodilation suggest multiple roles of nitric oxide during acute rejection of pulmonary allografts. AU - Wiklund, L.. AU - Lewis, D. H.. AU - Sjoquist, P. O.. AU - Nilsson, F.. AU - Tazelaar, H.. AU - Miller, V. M.. AU - McGregor, C. G.A.. PY - 1997/7/22. Y1 - 1997/7/22. N2 - Experiments were designed to determine whether changes in pulmonary artery function could be reduced by treatment with a lipid peroxidation inhibitor (H 290/51) during acute rejection of pulmonary allografts. Single lung transplantation was performed in three groups of dogs: group 1 was maintained on immunosuppression for 8 days after operation (immunosuppressed, n = 5); in group 2, immunosuppression was discontinued on postoperative day 5, so that rejection occurred on postoperative day 8 (rejecting, n = 6); in group 3, immunosuppression was discontinued after 5 days, and the lipid peroxidation inhibitor H 290/51 (25 mg/kg) was ...
Importance: Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). Previous studies have suggested that azithromycin may reduce the incidence of post-lung transplant bronchiolitis obliterans syndrome. Objective: To evaluate if the early administration of azithromycin can improve airflow decline-free survival after allogeneic HSCT. Design, Setting, and Participants: The ALLOZITHRO parallel-group trial conducted in 19 French academic transplant centers and involving participants who were at least 16 years old, had undergone allogeneic HSCT for a hematological malignancy, and had available pretransplant pulmonary function test results. Enrollment was from February 2014 to August 2015 with follow-up through April 26, 2017. Interventions: Patients were randomly assigned to receive 3 times a week either 250 mg of azithromycin (n = 243) or placebo (n = 237) for 2 years, starting at the time of the ...
Despite his underlying lung condition, Anthony was able to move around and exercise with little or no supplemental oxygen before getting infected with COVID-19. After COVID-19, it was a different ballgame, he said. He required higher and higher levels of oxygen but it became clear that he couldnt survive on a ventilator. He was placed on a transplant wait list, and, to buy time, his care team put him on ECMO (extracorporeal membrane oxygenation), which works like the heart and lungs to remove carbon dioxide and return oxygen-filled blood back to the tissues. Then, on Feb. 6, Anthony became the first COVID-related lung transplantation patient at UMMC.. COVID-19 was also a different ballgame for the UMMC lung transplant team, which routinely performs 25-30 lung transplants each year. Unique to COVID-19 is the rapid ebb and flow of symptoms. Within a matter of months, the two men were sick with COVID-19, then seemingly recovered from their initial infection only to get sick again, the second ...
2016 Elsevier Inc. Background Primary graft dysfunction (PGD) is a frequent complication after cardiac transplantation and remains one of the leading causes of mortality in these patients. The objective of this case-control study is to identify donor and surgical procedures factors associated with PGD, and further guide possible strategies to prevent PGD. Methods Retrospective analysis of the medical records of patients who underwent cardiac transplantation at Memorial Hermann Hospital at Texas Medical Center between October 2012 and February 2015. Results The study population included 99 patients, of which 18 developed PGD. Univariate analysis of donor characteristics revealed opioid use (P =.049) and death owing to anoxia (P =.021) were associated with PGD. The recipient/donor blood type match AB/A was significantly associated with PGD (P =.031). Time from brain death to aortic cross clamp (TBDACC) of ≥3 and ≥5 days were also found to be associated with PGD (P =.0011 and.0003, ...
The survival associated with double lung transplantation (LTx) is 7.1 years, however, closer inspection of recipient pre-LTx disease demonstrates that survival amongst COPD patients (related to cigarette smoke [CS] exposure) is amongst the worst at 5.5 years, as compared to 8.9 years in cystic fibrosis patients. A number of risk factors are thought to lead to this observed inferior outcome, chief amongst these, are pre-LTx diagnosis, recipient and donor age, and donor CS history. Indeed, CS exposure in either the recipients or donors has been linked with increased rates of severe primary graft dysfunction, acute rejection (AR), and ultimately earlier graft failure. The goal of these proposed studies is to demonstrate evidence that CS exposure, either donor or recipient, alters the local lung-specific immune environment in such a way as to predispose to exacerbated ischemia-reperfusion injury (IRI), with a resultant worsening of AR. We first examined the role of CS exposure on the lung ...
Global Markets Directs, Lung Transplant Rejection - Pipeline Review, H1 2020, provides an overview of the Lung Transplant Rejection pipeline
By Megan Rauscher. NEW YORK (Reuters Health) - Lung transplantation in children with cystic fibrosis (CF) is not likely to prolong life and may do more harm than good, according to a look back at essentially the entire U.S. pediatric experience with lung transplantation for cystic fibrosis for the period 1992 through 2002.. According to a report in November 22 issue of The New England Journal of Medicine, a total of 248 of the 514 children with cystic fibrosis who were on the waiting list during the 10-year-period underwent lung transplantation.. Children undergoing lung transplant did much worse than expected, Dr. Theodore G. Liou of the University of Utah, Salt Lake City, told Reuters Health.. We fully expected, at the start of the study, that we would find a group that did well and others that did not do so well. Unfortunately, we found that the group that most likely did well with transplant was very small, while the group that most likely did poorly (worse than if not transplanted) was ...
Citing reports, the drug device platform of Breath Therapeutics involves a liposomal cyclosporine A for the delivery of inhaled drug with PARI Pharmas eFlow nebulizer technology. L-CsA-i, the lead product candidate, has initiated two global phase 3 clinical trials to treat Bronchiolitis obliterans syndrome (BOS), the post-lung transplantation which is respiratory orphan disease that can be fatal and has no approved therapies.. Breath Therapeutics Board Member and Sofinnova Partners Managing Partner, Graziano Seghezzi, said that Breath Therapeutics is a cutting-edge platform with smart entrepreneurs developing products to treat devastating diseases that have no effective treatment, standing as perfect symbol for the companys investment strategy.. The company had clear vision for transatlantic operation that has strong bases in the U.S. and Europe in order to maximize any commercial opportunity. The company believes it has achieved the said vision and has gathered an excellent management team ...
PubMed journal article Primary graft dysfunction and long-term pulmonary function after lung transplantatio were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Lung transplantation[edit]. The Duffy antigen has been implicated in lung transplantation rejection.[92] ... Its expression is increased in the vascular beds and alveolar septa of the lung parenchyma during suppurative pneumonia.[94] ... Transplantation. 75 (7): 1030-4. doi:10.1097/01.TP.0000054679.91112.6F. PMID 12698093. S2CID 22739165.. ... "The role of chemokine receptors in acute lung allograft rejection". Eur. Respir. J. 35 (1): 167-75. doi:10.1183/ ...
Lung transplantation. *Intestinal transplantation (isolated small bowel, intestine & liver, multivisceral). *Liver transplants ... Allotransplant (allo- meaning "other" in Greek) is the transplantation of cells, tissues, or organs to a recipient from a ... It is contrasted with autotransplantation (from one part of the body to another in the same person), syngeneic transplantation ... Allogeneic stem cell transplantation entry in the public domain NCI Dictionary of Cancer Terms ...
"History of Lung Transplantation". Emory University. April 12, 2005. Archived from the original on October 2, 2009. Retrieved ... The heart of a chimpanzee was used for the heart transplant because of Hardy's research on transplantation, consisting of ... University of Mississippi Medical Center surgeons, led by James Hardy, performed the world's first human lung transplant, in ...
Supportive care, various medications, lung transplantation[1][6]. Medication. Epoprostenol, treprostinil, iloprost, bosentan, ... "National Heart, Lung, and Blood Institute.. *^ a b c d e f g Frank Gaillard. "Pulmonary hypertension". Radiopaedia. Retrieved ... Lung transplantation may be an option in severe cases.[6] While the exact frequency of the condition is unknown, it is ... The Journal of Heart and Lung Transplantation. 31 (9): 913-33. doi:10.1016/j.healun.2012.06.002. PMID 22884380.. ...
Lau, CL; Patterson, GA (Nov 2003). "Current status of lung transplantation". The European Respiratory Journal. Supplement. 47: ... a b c ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young ... Nicod, LP (Jul 2006). "Mechanisms of airway obliteration after lung transplantation". Proceedings of the American Thoracic ... "Current status of paediatric heart, lung, and heart-lung transplantation". Archives of Disease in Childhood. 89 (4): 386-389. ...
"The Journal of Heart and Lung Transplantation. 34 (11): 1366-1375. doi:10.1016/j.healun.2015.05.025. PMID 26210752.. ...
Bhorade, S. M.; Stern, E. (2009-01-15). "Immunosuppression for Lung Transplantation". Proceedings of the American Thoracic ... Abdi, Reza; Spencer Martin; Steven Gabardi (2009). "Immunosuppressive Strategies in Human Renal Transplantation - Induction ... Clinical Transplantation. 17 (1): 69-74. doi:10.1034/j.1399-0012.2003.02105.x. PMID 12588325. S2CID 8677441. Mutschler, Ernst; ... Bone Marrow Transplantation. 38 (5): 365-370. doi:10.1038/sj.bmt.1705450. ISSN 1476-5365. PMID 16862164. S2CID 31056997. " ...
Matthew, Henry; Logan, Andrew; Woodruff, M. F. A.; Heard, Brian (1968). "Paraquat Poisoning-Lung Transplantation". British ... In 1968 he performed the first lung transplant in the UK (the fifth in the world) on a patient whose lungs had been damaged by ... He assisted at the first pneumonectomy in the UK and performed the first lung transplant in the UK. He was born in Strathaven, ... Logan later described how he was left to remove the necrotic lung as planned on the 10th post-operative day. During World War ...
Heart and Lung Transplantation. 4 February 2019. Bogaev, R; Chen, L; Russell, SD; et al. (2007). "Medical Aspects of End-Stage ... The Journal of Heart and Lung Transplantation. 29 (4): S1-39. doi:10.1016/j.healun.2010.01.011. PMID 20181499. Fukamachi, Kiyo ... Normally, the long-term VAD is used as a bridge to transplantation (BTT) - keeping the patient alive, and in reasonably good ... The study is to assess the system as bridge-to-transplantation for patients with end-stage heart failure. The study, Evaluation ...
... is one-year survival after transplantation of the lungs. Factors used to predict it include ... Vigneswaran, Wickii; Garrity, Edward; Odell, John (2016). Lung Transplantation: Principles and Practice. CRC Press. p. 67. ISBN ... The final lung allocation score, which is meant to reflect the overall transplant benefit, incorporates this element as well. ...
Vigneswaran, Wickii; Garrity, Edward; Odell, John (2016-01-05). Lung Transplantation: Principles and Practice. ISBN ... Lung Transplantation: Principles and Practice. ISBN 9781482233940. Ghatak, Subrata (2009-09-21). Life Care Planning and Case ... measure is a measure of evaluating the conditions of the patient before transplantation of an organ especially the lungs. It is ... It is used, for example, for calculation of Lung allocation score based on the formula: Raw LAS = Transplant benefit measure - ...
His research focused largely on the lungs and on the liver, though he is also known for his work on intestinal transplantation ... He performed the first ever simultaneous bilateral lung transplantation in canines, one of many such operations paving the way ... Hardy, James D.; Alican, Fikri (1966). "Lung Transplantation". Advances in Surgery. 2: 235-264. ISSN 0065-3411. PMID 5333296. ... Alican, Fikri (December 1970). "The Present Status of Lung Transplantation". Journal of the Tennessee Medical Association [ ...
Lung transplantation as a case study". Ann Surg. 218 (4): 465-73, discussion 474-5. doi:10.1097/00000658-199310000-00007. PMC ... He received the International Society for Heart and Lung Transplantation (ISHLT) Lifetime Achievement Award in 1999. Reemtsma ... "ISHLT: The International Society for Heart & Lung Transplantation - 1999 Lifetime Achievement Award Recipient". ... In 1963, James Hardy, who had carried out the first human lung allotransplant, visited Reemtsma and was impressed by the ...
Lung Transplantation. Retrieved April 4, 2015. "ISHLT: The International Society for Heart & Lung Transplantation - 2012 ... "Severe tricuspid regurgitation after heart transplantation". The Journal of Heart and Lung Transplantation. 20 (7): 709-717. ... She is a past president of the International Society for Heart and Lung Transplantation and received their lifetime achievement ... Hunt succeeded John Wallwork in 1995 to serve as president of the International Society for Heart & Lung Transplantation from ...
He has served as president of the International Society for Heart and Lung Transplantation (ISHLT) and is the editor-in-chief ... History of International Heart and Lung Transplantation, co-authored with James K. Kirklin and Lori J. West, Elsevier (2010). ... The International Society for Heart and Lung Transplantation (31 March 2016), Mandeep R. Mehra, MBBS, FACC, FACP, retrieved 6 ... Journal of Heart and Lung Transplantation. Retrieved June 6, 2015. Stiles, Steve (February 1, 2012). "Dr Mandeep Mehra leaves ...
His team did the first lung transplantation of Brazil and Latin America, in 1989. He also did the first double lung transplant ... S.l.: s.n.] 87 páginas Pêgo-Fernandes, Paulo Manuel; Mariani, Alessandro Wasum (November 2009). "Brazilian lung transplantation ... His team is the team that transplant more lung in the country. In 2015, 60% of the Brazilian lung transplants are of his team. ...
Lung Transplantation Reveals 2014 Award Winners" (PDF). International Society for Heart & Lung Transplantation. 10 April 2014. ... 2014 - Lifetime Achievement Award from the International Society for Heart and Lung Transplantation in Recognition of ... he has also been President of International Society of Heart and Lung Transplantation 1984-1985 and holds multiple ... A Jarvic 7 heart was used as a bridge to transplantation until a human donor heart could be found and the patient subsequently ...
"What's old is new again: Palliative Potts shunt in children with PAH". International Society for Heart & Lung Transplantation. ... In 1953, Potts was the first surgeon to successfully repair a pulmonary artery sling, an abnormality in which the lung blood ... she had decreased blood flow to the left lung, but she was doing well. Potts and his team also advanced the treatment of a ... the group of heart defects that result in insufficient blood flow to the lungs. They became intrigued by the idea of somehow ...
The definitive therapy is lung transplantation, though transplant rejection is always a possibility, in this measures must be ... The definitive therapy is lung transplantation. The symptoms for pulmonary veno-occlusive disease are the following: Shortness ... Cite journal requires ,journal= (help) "Lung Transplantation: MedlinePlus". Retrieved 2015-11-07. CS1 maint: ... The blockage leads to high blood pressures in the arteries of the lungs, which, in turn, leads to heart failure. The disease is ...
Palmer SM, Layish DT, Kussin PS, Oury T, Davis RD, Tapson VF (February 1998). "Lung transplantation for Williams-Campbell ... Burguete SR, Levine SM, Restrepo MI, Angel LF, Levine DJ, Coalson JJ, Peters JI (September 2012). "Lung transplantation for ... Surgery to remove part of the lungs is often considered for people with extreme damage to one or two lobes of the lung who are ... However, lung biopsy has several complications and is not always diagnostic.[citation needed] Considering its non-invasive ...
Eddy, S. "Dextrocardia and Proper Lead Placement". Deuse, Tobias; Reitz, Bruce A. (September 2009). "Heart-Lung Transplantation ... When heart transplantation is required in a person with situs inversus, reconstruction of the venous pathways to accommodate a ...
... a dilemma for lung transplantation". The Journal of Heart and Lung Transplantation. 22 (2): 210-3. doi:10.1016/S1053-2498(02) ... Lung toxicity is a serious complication associated with sirolimus therapy, especially in the case of lung transplants. The ... The Journal of Heart and Lung Transplantation. 26 (3): 296-8. doi:10.1016/j.healun.2006.12.004. PMID 17346635. Delgado JF, ... The Journal of Heart and Lung Transplantation. 25 (9): 1171-4. doi:10.1016/j.healun.2006.05.013. PMID 16962483. McWilliams TJ, ...
The Journal of Heart and Lung Transplantation. 29 (5): 509-516. doi:10.1016/j.healun.2009.11.602. PMID 20061166. Sombogaard F, ... 2008). "Association of four DNA polymorphisms with acute rejection after kidney transplantation". Transpl. Int. 21 (9): 879-91 ... a 2-year follow-up in kidney transplantation". Clin. Pharmacol. Ther. 83 (2): 328-35. doi:10.1038/sj.clpt.6100300. PMID ...
The Journal of Heart and Lung Transplantation. 28 (10): 1007-1022. doi:10.1016/j.healun.2009.08.014. PMID 19782283.CS1 maint: ... "Registry of the International Society for Heart and Lung Transplantation: twenty-sixth official adult heart transplant report- ... In typical anatomy, the left side of the heart receives oxygen-rich blood from the lungs and pumps it to the rest of the body. ... As blood returns from the lungs to the left atrium, it cannot be pumped to the rest of the body by the left ventricle. The ...
Lung transplantation may be an option in those with very severe disease. The disease affects between 1 per 1000 and 1 per ... Corris, PA (Jun 2013). "Lung transplantation for cystic fibrosis and bronchiectasis". Seminars in Respiratory and Critical Care ... Obstructive lung impairment is the most common finding but restrictive lung impairment can be seen in advanced disease. ... In preventing bronchiectasis, it is necessary to prevent the lung infections and lung damage that can cause it. Children should ...
The Journal of Heart and Lung Transplantation. 27 (4): 457-61. doi:10.1016/j.healun.2008.01.013. PMID 18374884. Basic & ... Circulation & Lung Physiology I Archived 2011-07-26 at the Wayback Machine M.A.S.T.E.R. Learning Program, UC Davis School of ...
The Journal of Heart and Lung Transplantation. 21 (10): 1131-4. doi:10.1016/s1053-2498(02)00404-7. PMID 12398880. Athar MA, ... "Delayed sternotomy wound infection due to Paecilomyces variotii in a lung transplant recipient". ...
Cabrol was involved with the International Society for Heart and Lung Transplantation (ISHLT) from its inception in 1981. In ... The subject of his thesis was the anatomy of the lung. The book on the right lung was published in 1953, and on the left lung ... "ISHLT: The International Society for Heart & Lung Transplantation - Past Presidents". Retrieved 3 January 2019. ... Copeland, Jack (September 2017). "Professor Christian Cabrol (1925 to 2017)". The Journal of Heart and Lung Transplantation. 36 ...
It is possible for candidiasis to spread to/from the mouth, from sites such as the pharynx, esophagus, lungs, liver, anogenital ... organ transplantation and use of indwelling catheters). Oral candidiasis has been recognized throughout recorded history. The ...
... (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation. American Society for Blood and Marrow Transplantation. 2 (1): 3-14. PMID 9078349. ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ... a b Memorial Sloan-Kettering Cancer Center , Blood & Marrow Stem Cell Transplantation , The Graft-versus-Tumor Effect Archived ...
... lungs, digestive tract, urinary tract, etc.). ... Transplantation medicine. *Tropical medicine *Travel medicine. ...
... such as lungs) especially lend themselves to projection radiography. It is a relatively low-cost investigation with a high ...
Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... The physical examination typically includes an assessment of volume state, blood pressure, heart, lungs, peripheral arteries, ... Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ... At present, renal transplantation is the most effective treatment for end-stage kidney failure although its worldwide ...
National Heart, Lung, and Blood Institute Working Group on Restless Legs Syndrome". American family physician 62 (1): 108-14. ... Nephrology Dialysis Transplantation 21: 184-90. doi:10.1093/ndt/gfi144. ...
Liver transplantation may be a valid option if no improvement occurs.[33] ... while the lung and kidneys may also be capable of storage.[20] ...
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The "donor" hand usually comes ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team,[14] performed a hand ... "Hand transplantation" - news · newspapers · books · scholar · JSTOR (April 2017) (Learn how and when to remove this template ...
lung. Pneumonectomy. Lobectomy. Wedge resection. Lung transplantation. Decortication of lung. Heart-lung transplant. ... Total lung capacity (TLC)[edit]. Total lung capacity (TLC) is the maximum volume of air present in the lungs ... Static lung compliance (Cst)[edit]. When estimating static lung compliance, volume measurements by the spirometer needs to be ... Tidal volume: that volume of air moved into or out of the lungs during quiet breathing (TV indicates a subdivision of the lung ...
For those with very severe disease, surgery is sometimes helpful and may include lung transplantation or lung volume-reduction ... Stopping smoking, respiratory rehabilitation, lung transplantation[2]. Medication. Vaccinations, inhaled bronchodilators and ... Gross pathology of a lung showing centrilobular emphysema characteristic of smoking. This close-up of the fixed, cut lung ... "Morbidity & Mortality: 2009 Chart Book on Cardiovascular, Lung, and Blood Diseases" (PDF). National Heart, Lung, and Blood ...
People with Hunter syndrome may also have limited lung capacity due to pulmonary involvement. As the liver and spleen grow ... For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... long term follow-up on patients undergone to hematopoietic stem cell transplantation, Minerva Pediatr. 2013 Oct;65(5):487-96. ...
Iradj Gandjbakhch (b. 1941), cardiac surgeon, performed Europe's first heart transplantation on 27 April 1968 along with Dr. ... from the metastatic spread of lung cancer). ... performed Europe's first heart transplantation on 27 April 1968 ...
As the diaphragm and intercostal muscles of the rib cage that support breathing weaken, measures of lung function such as vital ... "Intraspinal stem cell transplantation for amyotrophic lateral sclerosis". Annals of Neurology. 79 (3): 342-53. doi:10.1002/ana ... with chewing and swallowing make eating very difficult and increases the risk of choking or of aspirating food into the lungs. ...
Joseph's Lung Transplantation Program", Accessed October 13, 2010. *^ "St. Joseph's Expects Lung Transplant Program to Nearly ... "Center for Thoracic Transplantation", Accessed September 24, 2010. *^ "Best Hospitals 2009 Specialty Search: Neurology and ... It includes the Barrow Neurological Institute, the Heart & Lung Institute, and a Level I Trauma Center verified by the American ... Joseph's Hospital also has a Lung Transplant Program, which offers transplants to those individuals diagnosed with high-risk ...
VUMC has also had more than 2000 liver transplants and 600 heart and lung transplants. Among Vanderbilt's other transplant ... Vanderbilt also offers an organ transplantation center. Vanderbilt's first kidney transplant was in 1962; since then there have ... lungs and liver in 2000.[16] The Vanderbilt-Ingram Cancer Center is one of 42 National Cancer Institute-designated cancer ... milestones were Tennessee's first pancreas transplant in 1985, the first successful heart-lung transplant in the state, in 1987 ...
Stimulation of the larynx by ingested matter produces a strong cough reflex in order to protect the lungs. ... Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ... opening to prevent any food that is being swallowed from entering the larynx which leads to the lungs; the larynx is also ...
lung. Pneumonectomy. Lobectomy. Wedge resection. Lung transplantation. Decortication of lung. Heart-lung transplant. ... It is a very common approach for operations on the lung or posterior mediastinum, including the esophagus. When performed over ... the lungs, or the esophagus, or for access to the thoracic aorta or the anterior spine (the latter may be necessary to access ... complications such as pleural effusion or hemothorax can occur if the chest tubes fail to drain the fluid around the lung in ...
For the development of liver transplantation, which has restored normal life to thousands of patients with end-stage liver ... 1980 - National Heart, Lung, and Blood Institute. *1984 - Dorothy T. Krieger. *1987 - Centennial Salute to the National ...
The hospital is the largest centre for child heart surgery in the UK and one of the largest centres for heart transplantation ... In 1962 they developed the first heart and lung bypass machine for children. With children's book author Roald Dahl, they ... They raised over £800,000 for a new lung function unit at the hospital.[32] ...
The blood type needs to be determined to prepare for a blood transfusion or an organ transplantation. ... in the lungs or gills and release them throughout the body. Oxygen can easily diffuse through the red blood cell's cell ... is transported back to the pulmonary capillaries of the lungs as bicarbonate (HCO3−) dissolved in the blood plasma. Myoglobin, ... RBCs take up oxygen in the lungs, or gills of fish, and release it into tissues while squeezing through the body's capillaries ...
The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ... lung. This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918) editor-in-chief, Susan ...
Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ... Medical imaging (such as ultrasound or CT scanning) can find invasion of other organs commonly the lung, liver, spleen, lymph ... Chemotherapies or stem cell transplantations may require a platelet transfusion to prevent bleeding.[58][59] Moreover, patients ... Stem cell transplantation may be used if the disease recurs following standard treatment.[2] Additional treatments such as ...
Hematopoietic stem cell transplantation (HSCT) with high intensity conditioning protocol has been performed in a few cases with ... In a minority of patients with SPS, breast, ovarian, or lung cancer manifests paraneoplasticly as proximal muscle stiffness. ... There is a limited but encouraging therapeutic experience of hematopoietic stem cell transplantation for SPS. ... "Autologous Stem Cell Transplantation for Stiff Person Syndrome". JAMA Neurology. 71 (10): 1296-9. doi:10.1001/jamaneurol. ...
There are also reports of hematopoiesis taking place in the lungs. These cases are associated with hypertension in the ... The one known curative treatment is allogeneic stem cell transplantation, but this approach involves significant risks.[15] ...
... or deposited in the lungs of personnel. These instruments will normally give a local alarm, but are often connected to an ... a similar concept which is applied in hematopoietic stem cell transplantation (HSCT), which is a common treatment for patients ...
It also occasionally affects spleen, lymph nodes, lungs, kidneys, adrenal glands, bone marrow, and other parts of ... "Laparoscopic study of peliosis hepatis and nodular transformation of the liver before and after renal transplantation: natural ...
... because the damage done to the lungs can cause the same types of changes to lung function testing that are seen in asthma. ... Thoracentesis Diet rich in medium-chain triglycerides and protein Chemotherapy Sclerotherapy Transplantation Skeletal: ... Lymphangiomatosis patients, families, and caregivers are encouraged to join the NIH Rare Lung Diseases Consortium Contact ... lung): Pleurodesis Ligation of thoracic duct Pleurperitoneal shunt Radiation therapy Pleurectomy Surgical resection Thalidomide ...
"Risk factors for death of patients with cystic fibrosis awaiting lung transplantation". Am. J. Respir. Crit. Care Med. 173 (6 ... "Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease 11 (11): ... 48.0 48.1 Saiman L (2004). "Microbiology of early CF lung disease". Paediatric Respiratory Reviews 5 (Suppl A): S367-69. . PMID ... Ciofu, O; Lykkesfeldt, J (Aug 7, 2014). "Antioxidant supplementation for lung disease in cystic fibrosis.". The Cochrane ...
"Biology of Blood and Marrow Transplantation. 15 (12): 1628-33. PMC 2861656 . PMID 19896087. doi:10.1016/j.bbmt.2009.07.004.. ... Lung cancer. Cyclophosphamide, doxorubicin, vincristine,. CAV. Colorectal cancer. 5-fluorouracil, folinic acid, oxaliplatin. ... Colorectal, lung, ovarian and brain cancer. 3. $6.56 billion. Trastuzumab. Herceptin. Roche. Breast, esophagus and stomach ... Isolated limb perfusion (often used in melanoma),[61] or isolated infusion of chemotherapy into the liver[62] or the lung have ...
According to the American Lung Association's Center for Tobacco Policy and Organizing, 12 cities and 1 county in California ... and organ transplantation.[137][138][139] ...
Lung Transplantation Lung transplantation research such as mechanisms of acute cellular and antibody-mediated rejection; ... primary graft dysfunction; and chronic lung allograft dysfunction, including bronchiolitis obliterans and restrictive allograft ...
Discover what to expect before, after, and during a lung transplant. ... A lung transplant removes a diseased lung and replaces it with a healthy one. ... Article: Bilateral lobar lung transplantation and a single lung transplantation using lungs... ... A lung transplant removes a persons diseased lung and replaces it with a healthy one. The healthy lung comes from a donor who ...
J Heart Lung Transplant. 1996 May;15(5):536-8.. Heart-lung-liver transplantation.. Dennis CM1, McNeil KD, Dunning J, Stewart S ... Heart-lung and concurrent liver transplantation is a feasible and successful procedure with a satisfactory long-term outcome in ... Liver transplantation was necessary in the three patients with cystic fibrosis because of portal hypertension secondary to ... Three of the four patients were alive at 20, 50, and 100 months after transplantation (one patient with cystic fibrosis died on ...
Candidates for Lung Transplantation. Candidates for lung transplants have end-stage lung disease with a poor prognosis and have ... The native diseased lung or lungs are removed from the recipient while the donor lung is being recovered. The donor lung (or ... double lung transplantation for those under 65 and heart-lung transplantation for those under 60.. Patients must be ambulatory ... lung transplantation and heart-lung transplantation. *Follow-up care including spirometry, bronchoscopy, transbronchial ...
Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the ... bronchiolitis obliterans syndrome delayed allograft dysfunction lung allograft rejection lung transplantation obliterative ... Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important ... Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the ...
Interstitial lung disease (ILP) (34.0%) Chronic obstructive pulmonary disease (COPD) (21.4%) ... more ... The main indications for single-lung transplantation, as reported by ISHLT 2018, include the following: ... Drugs & Diseases , Pathology , Lung Transplantation-Related Pathology Q&A What are the indications for lung transplantation?. ... The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung ...
Lung transplantation (LTx) is a treatment option for infants and children with untreatable and otherwise fatal pulmonary ... Pediatric lung transplantation: indications and outcomes.. Kirkby S1, Hayes D Jr1. ... Section of Pulmonary Medicine, Lung and Heart-Lung Transplant Program, Nationwide Childrens Hospital and The Ohio State ... To date, over 1,800 lung transplants have been performed, most frequently in children over the age of five years. The most ...
... Montefiores Advanced Lung Disease Program is home to a team of nationally recognized specialists with ... From complex cardiac surgery for patients experiencing lung failure and other pulmonary issues, to lung surgery required as ... The Advanced Lung Disease Program at Montefiore and our Department of Cardiothoracic and Vascular Surgery and Department of ... Our surgeons have performed a combined total of more than 1,000 lung transplants throughout their careers and achieved outcome ...
Research in the Laboratory of Transplantation Immunotherapy, led by Dr. Richard W. Childs, is focused on finding ways to adapt ...
We report 2 cases of lung transplant recipients treated with tacrolimus who developed cerebral microbleeds on T2*-weighted ... Tacrolimus-Related Cerebral Microbleeds after Lung Transplantation. L. Mechtouff. ,1 F. Piegay. ,2. ,. 3. ,. 4 J. Traclet. ,4 F ... A 26-year-old cystic fibrosis patient underwent double lung transplantation with a troubled course and a long stay in the ... A 19-year-old cystic fibrosis patient with a history of diabetes underwent double lung transplantation. He was started on ...
Lung transplantation can extend and improve your quality of life, but it involves an extensive evaluation process and a ... commitment to living the lifestyle required to keep your new lungs healthy. ... Many people with cystic fibrosis face the possibility of a lung transplant. ... Lung Transplantation Many people with cystic fibrosis face the possibility of a lung transplant. Lung transplantation can ...
Make research projects and school reports about Lung transplantation easy with credible articles from our FREE, online ... and pictures about Lung transplantation at ... The purpose of lung transplantation is to replace a lung that ... Lung transplantation. Definition. Lung transplantation involves removal of one or both diseased lungs from a patient and the ... Lung Transplantation. Definition. Lung transplantation involves removal of one or both diseased lungs from a patient and the ...
by Applied Radiology; Health, general Cardiac patients Organ transplantation Transplantation of organs, tissues, ... Overview of lung transplantation For many patients with end-stage lung disease, lung transplant is the only option available, ... Registry of the International Society for Heart and Lung Transplantation: Twenty-first official adult lung and heart Lung ... J Heart Lung Transplant. 2004;23:804-815. (3.) Collins J. Imaging of the chest after lung transplantation. J Thorac Imaging. ...
... After a lung transplant, patents are generally given drugs ... More articles about Lung Transplantation:. * Before Transplantation - Getting on the Transplant List ... This information originally appeared in the University Hospitals Lung Transplantation Patient Handbook, and was adapted for use ... This is to prevent the body from rejecting the new lungs.. Because the bodys immune system is being suppressed, patients may ...
Bilateral Lung Transplantation With Interventional Occlusion of an Atrial Septal Defect in a Patient With Eisenmenger Syndrome ... Bilateral Lung Transplantation With Interventional Occlusion of an Atrial Septal Defect in a Patient With Eisenmenger Syndrome ... Home , May 2017 - Volume 101 - Issue 5S-3 , Bilateral Lung Transplantation With Interventional Occlusion... ... On October 20, 2014, the patient was admitted to our Hospital to undergo preoperative assessment for lung transplantation. An ...
A forum that includes all aspects of pre-clinical and clinical science of the failing heart and lung.The Official Publication ... The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Lung and Heart-Lung Transplant ... The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Lung and Heart-Lung Transplant ... The Journal of Heart and Lung Transplantation. A forum that includes basic science, the failing heart, and advanced lung ...
A lung transplant removes a persons diseased lung and replaces it with a healthy one. The healthy lung comes from a donor who ... Complications of lung transplantation include rejection of the transplanted lung and infection. ... Lung transplants are used for people who are likely to die from lung disease within 1 to 2 years. Their conditions are so ... Lung transplants most often are used to treat people who have severe ...
Pediatric lung transplantation. Proc Am Thorac Soc. 2009 Jan 15;6(1):122-7. doi: 10.1513/pats.200808-095GO. Review. ... MedlinePlus related topics: Lung Transplantation Genetic and Rare Diseases Information Center resources: Bronchiolitis ... Lung transplantation: past, present, and future. Minerva Chir. 2009 Feb;64(1):37-44. Review. ... Saber-sheath trachea in a patient with bronchiolitis obliterans syndrome after lung transplantation. Chron Respir Dis. 2009;6(1 ...
... G. M. Ferraroli,3 M. Ravini,1 M ... "Successful Treatment of Bronchial Dehiscence With Endobronchial Stent in Lung Transplantation," Diagnostic and Therapeutic ...
... to receive a minimally invasive double lung transplant. The procedure was performed at the Smidt Heart Institute. ...
Viral Triggers in Pediatric Lung Transplantation. The safety and scientific validity of this study is the responsibility of the ... Pediatric lung transplantation. Proc Am Thorac Soc. 2009 Jan 15;6(1):122-7. doi: 10.1513/pats.200808-095GO. Review. ... MedlinePlus related topics: Lung Transplantation Genetic and Rare Diseases Information Center resources: Bronchiolitis ... Lung transplantation: past, present, and future. Minerva Chir. 2009 Feb;64(1):37-44. Review. ...
... lung transplantation can be a valuable therapy for patients with end-stage lymphangioleiomyomatosis. ... pneumothorax in the native lung after single-lung transplantation in 6 patients; postoperative chylothorax in 3; and recurrent ... Lung transplantation for lymphangioleiomyomatosis N Engl J Med. 1996 Oct 24;335(17):1275-80. doi: 10.1056/NEJM199610243351704. ... Lung transplantation is a recent therapeutic approach. Methods: We conducted a retrospective study by questionnaire of 34 ...
... heart and lung transplant surgeons have followed a strict directive: Get the donor organ into the recipient as soon as possible ... Lung Transplantation.. "This is the most exciting advance in lung transplantation since we first started 25 years ago," said ... "Its converting lungs you cant use into lungs you can use. At the moment, we are only using about 20%, worldwide, of the lungs ... The technique marks a paradigm shift in the transplantation field, experts noted. About 85% of lungs made available for ...
... Chest. 1996 May;109(5):1176-83. doi: 10.1378/chest.109.5.1176. ... lung transplantation (LTx). We measured bone mineral density (BMD) before and after LTx to determine the frequency and severity ... Nevertheless, considerable osteoporosis was present in the patients with COPD and other lung diseases before and after LTx. The ... mean spine and femoral BMD than patients with COPD or other lung diseases both before and after LTx. ...
Natural killer (NK) cells are innate lymphoid cells that have been increasingly recognised as important in lung allograft ... further understanding of NK cell biology in lung allograft recipients may allow these cells to serve as biomarkers of graft ... their diverse receptors and the mechanisms through which NK cells are postulated to mediate important lung transplant clinical ...
... study published in this months Anesthesiology highlights the potential of cell-based therapies for the treatment of acute lung ... Lam, however, emphasized that more animal studies need to be performed before EPC transplantation for acute lung injury can be ... "Our results obtained from a rabbit model of acute lung injury showed that transplantation of these premature EPCs significantly ... New Acute Lung Injury Study Finds Benefits of Autologous Cell Transplantation Therapy. ...
... lung transplantation offers hope for a second chance at life. Today, lung transplantation is a routine treatment, however, it ... Denton A. Cooley conducted the first successful heart-lung transplant in a 2-month-old girl with congestive heart failure and ... Lung Transplantation. For patients with end-stage lung disease, lung transplantation offers hope for a second chance at life. ... Today, lung transplantation is a routine treatment, however, it took twenty years of research between the 40s and 60s to ...
Pulmonary Fibrosis Lung Transplantation Webinar presented by Sangeeta Bhorade, MD of Northwestern University and David J. ... Lung Transplantation. January 14, 2015. Presented by:. Sangeeta Bhorade, MD. Medical Director, Lung Transplant Program ... For additional information on Lung Transplantation as a treatment for PF, visit our webinar series today!. Slides are available ... PFF Senior Medical Advisor, Patient Communications and Associate Medical Director of the New York Presbyterian Lung Transplant ...
Timing of Single Lung Transplantation for Primary Pulmonary Hypertension. Journal of Heart and Lung Transplantation, Vol. 13, ...
  • Lung transplants are used for people who are likely to die from lung disease within 1 to 2 years. (
  • Today, lung transplants are performed under the auspices of the multidisciplinary Women's Guild Lung Institute, part of the Comprehensive Transplant Center. (
  • As one of only a few medical centers in Southern California with Medicare certification for lung transplants, Cedars-Sinai offers a high level of experience and expertise in the surgical treatment of lung disease. (
  • Candidates for lung transplants have end-stage lung disease with a poor prognosis and have failed to respond to conventional medical therapy. (
  • To date, over 1,800 lung transplants have been performed, most frequently in children over the age of five years. (
  • Our surgeons have performed a combined total of more than 1,000 lung transplants throughout their careers and achieved outcome rates higher than the national average. (
  • Heart-lung transplants always require the use of cardiopulmonary bypass. (
  • 2) Although the procedure itself remains limited to various regional centers, as more and more patients with lung transplants return to their home communities, it will be important for radiologists to appropriately image as well as recognize complications that can result from the procedure. (
  • however, in cases of pulmonary fibrosis and selected cases of emphysema, single-lung transplants are acceptable and help to distribute needed organs to a larger population of critically ill patients. (
  • Because of the risk of infection and cross-contamination, unilateral lung transplants are contraindicated in patients with cystic fibrosis and bronchiectasis. (
  • Overall, an equal number of single- and double-lung transplants have been performed annually since 1995. (
  • Modern developments of oral drugs that protect against CMV and screening tests to detect CMV in the bloodstream have significantly decreased the burden of this agent in lung transplants. (
  • In a study published Wednesday in the New England Journal of Medicine , researchers said the number of donor lungs and successful transplants may be dramatically increased by treating the organs on a perfusion machine for several hours before transplantation. (
  • In October 2007 (93rd annual Clinical Congress Congress of the American College of Surgeons), Dr. Weiss reported that lung transplants improved survival rates in patients over 60 years of age. (
  • The number of deceased donor lung transplants increased by 78% since 1996, reaching 1407 in 2005 (up 22% from 2004). (
  • While lung transplants carry certain associated risks, they can also extend life expectancy and enhance the quality of life for end-stage pulmonary patients. (
  • Similarly, select HIV-infected individuals have received lung transplants after being evaluated on a case-by-case basis. (
  • 2 I agree that large-volume units are desirable, yet of the 158 centres reporting adult lung transplantation to the International Society for Heart and Lung Transplantation, 59% averaged fewer than 10 lung transplants a year. (
  • Over 100 pediatric lung transplants are reported to the International Society for Heart and Lung Transplantation ( ISHLT) Thoracic Transplant Registry annually. (
  • The article focuses on the under 12 rule of the Organ Procurement and Transplant Network (OPTN) wherein children under the age of 12 are prohibited from receiving adult sized lungs during transplants. (
  • Relevant SNPs related to Tac and MPA in other solid organ transplants also seem to be related to the efficacy and safety of treatment in the complex setting of lung transplantation. (
  • Only one in five of the potential donor lungs available in the UK are used in lung transplants, the rest are turned down as they are in too poor a condition to safely transplant. (
  • and heart-lung transplants. (
  • Lung transplants can now be performed in all ages--from newborn to adult. (
  • The availability of suitable donor lungs for transplantation continues to be a major obstacle to increasing the number of lung transplants performed annually," said William Whited, MD, of the University of Louisville in Kentucky. (
  • Between January 2005 and June 2014, 14,222 lung transplants were performed. (
  • The use of lungs from donors older than 60 years is rare, constituting only 2% of all lung transplants performed on younger patients from 2005 to 2014. (
  • Our team performs up to 60 transplants per year and has done nearly 1000 lung transplants. (
  • Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. (
  • Unlike transplantation of other solid organs, vascularized mouse lung transplants have only recently been reported by Okazaki and colleagues for the first time in 2007 5 . (
  • Applying the basic principles of the rat lung transplant, our lab initiated the obliterative bronchiolitis model using minor histoincompatible antigen murine orthotopic single-left lung transplants which allows the further study of obliterative bronchiolitis immunopathogenesis 6 . (
  • More than 50,000 lung transplants have been performed worldwide, and approximately 4,000 new lung transplants are performed each year. (
  • Idiopathic pulmonary fibrosis (IPF) is the most common indication for lung transplantation, accounting for 33% of transplants worldwide. (
  • Non-IPF interstitial lung diseases (8%), lung re-transplantation after graft failure (4%) and alpha-1 antitrypsin deficiency-associated emphysema (2%) are the other major indications, while a variety of other disorders of the lung parenchyma, airways, and vasculature each account for a small percentage of transplants annually. (
  • The presence of significant extrapulmonary vital organ dysfunction can sometimes be addressed with multi-organ transplants (e.g., heart-lung, liver-lung) in select candidates. (
  • Further analysis indicated that double-lung transplants were associated with better graft survival in patients with IPF (adjusted median survival, 65.2 months vs 50.4 months) but not in patients with COPD (adjusted median survival, 67.7 months vs 64.0 months). (
  • Increased risk of PTLD in lung transplant recipients with cystic fibrosis. (
  • Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. (
  • Tikkanen J, Lemstrom K, Halme M, Pakkala S, Taskinen E, Koskinen P. Cytological monitoring of peripheral blood, bronchoalveolar lavage fluid, and transbronchial biopsy specimens during acute rejection and cytomegalovirus infection in lung and heart--lung allograft recipients. (
  • Re-transplantation is an option for selected recipients with chronic allograft rejection. (
  • Other outcomes such as the incidence of bronchiolitis obliterans (BO) and the presence of key post-transplant co-morbid conditions are also similar to the experience in adult lung transplant recipients. (
  • We report 2 cases of lung transplant recipients treated with tacrolimus who developed cerebral microbleeds on T2*-weighted sequences in the acute setting of posterior reversible encephalopathy syndrome. (
  • We recently observed CMBs on MRI in two-lung-transplant recipients treated with tacrolimus in the acute setting of PRES. (
  • While the effects of immunosuppression agents on NK cells may currently be largely unintentional, further understanding of NK cell biology in lung allograft recipients may allow these cells to serve as biomarkers of graft injury and as therapeutic targets. (
  • To clarify the effect of CPB on lung transplant recipients, we reviewed our last four years' experience in 74 patients of whom 30 required CPB support. (
  • The International Society for Heart and Lung Transplantation (ISHLT) reports that since 1985 the percentage of older patients receiving lung transplantation has increased steadily, with 24 percent of recipients in 2006 being older than age 60. (
  • These data underscore the importance of carefully considering age among potential lung transplantation recipients," said Eric S. Weiss, MD, division of cardiac surgery, The John Hopkins Hospital, Baltimore, MD. "Although age is only one of many important criteria, advanced age appears to have a major impact on post-surgical mortality. (
  • The vast majority of lung transplant recipients receive a triple-drug maintenance regimen including a calcineurin inhibitor, a cell-cycle inhibitor and steroids. (
  • Indeed, lung transplant recipients may not consider themselves cured as 5‐yr actuarial survival only approximates 50% 1 . (
  • This article examines the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients data on heart and lung transplantation in the United States from 1996 to 2005. (
  • Death rates for both candidates and recipients have been dropping, as has the time spent waiting for a lung transplant. (
  • They demonstrate its efficacy as a means of reducing waiting-list mortality for paediatric lung transplantation recipients. (
  • Birks EJ, Yacoub MH, Anyanwu A, Smith RR, Banner NR, Khaghani A (2004) Transplantation using hearts from primary pulmonary hypertensive donors for recipients with a high pulmonary vascular resistance. (
  • Donor culture results identifying multidrug-resistant organisms should be promptly shared with the Organ Procurement and Transplantation Network so recipient healthcare centers can be notified in order to inform treatment of clinical infections and enable implementation of infection control measures to prevent further spread within the recipients' healthcare facilities. (
  • The diagnosis of humoral rejection in lung transplant recipients is sometimes elusive, involving histopathologic (capillaritis), immunopathologic (C4d staining), and serologic (donor-specific anti-HLA antibodies, DSA) parameters. (
  • A total of 60 consecutive lung transplant recipients were followed in our Institution from 2015. (
  • A total of 5 lung transplant recipients (8.33%) were C4d+ on biopsy but only one of them developed de novo DSA without evidence of non-HLA antibodies. (
  • In total, 117 lung transplant recipients, all white, due for their yearly follow-up at one (n=35), two (n=28), three (n=23), four (n=20) or five years (n=11) after transplantation were included. (
  • Many of the lung recipients lacked pain treatment and were uncertain about the reasons behind their pain. (
  • Female lung recipients experience more pain and pain related illness than men. (
  • Fig. 1 Radiographic and intraoperative findings in lung transplant recipients with severe COVID-19. (
  • Background: Lung transplant recipients are a high-risk population for invasive Aspergillus infections. (
  • Dr. Whited, along with senior author Matthew Fox, MD, and other colleagues from the University of Louisville queried the United Network of Organ Sharing (UNOS) thoracic transplant database to identify lung transplant recipients age 18 years or older. (
  • Of these lung transplant recipients, 26% were age 50 years or younger, with 2% receiving lungs from donors older than age 60. (
  • Does Donor Age and Double Versus Single Lung Transplantation Affect Survival of Young Recipients? (
  • This ERS/ESTS joint course will provide state-of-the-art knowledge of all issues regarding lung transplantation, including referral and selection criteria for potential lung transplant candidates, supply management and selection of suitable donor organs, early and long-term management issues of lung transplant recipients, management of immunosuppression and its side effects, and specific clinical and organizational issues of newly established or running lung transplant programmes, among others. (
  • Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. (
  • from lung recipients' perspective of their post-transplant recovery process and to identify the recovery trajectories including critical junctions in the post-transplant recovery process after lung transplantation. (
  • METHOD: Fifteen adult lung transplant recipients who were due their 12-month follow-up were consecutively included and interviewed during 2015. (
  • METHODS: Retrospective analyses of 75 lung transplant recipients who received downsized lungs with a special focus on 23 recipients with BLLT performed since January 2000. (
  • Overall survivals at 1 and 5 years were 82 ± 8 and 64 ± 11%, respectively and were comparable with those of 219 other recipients who received bilateral lung transplantation during the same period (log rank test, P = 0.56). (
  • The limitation of lung transplantation due to size-mismatch, particularly in smaller recipients, could be overcome by utilizing lobar lung transplantation. (
  • Methods 179 adults lung transplantation recipients between 1997 and 2014, that were evaluated for OP in Rheumatology Outpatient Clinic and who had available densitometry (BMD) lumbar and femoral (BMD) (Lunar Prodigy DXA System) prior and post transplantation were included. (
  • at 5 years, there has been no survival difference between single- and double-lung transplant recipients in patients with chronic obstructive pulmonary disease (COPD), according to a study in the March 3 issue of JAMA . (
  • Recipients were euthanized 7 days after transplantation. (
  • ACUTE cellular rejection is a type of organ dysfunction initiated by cell-mediated immunity in lung-transplant recipients. (
  • We report three patients with cystic fibrosis and one patient with primary biliary cirrhosis and plexogenic pulmonary hypertension who have undergone heart-lung-liver transplantation as a combined procedure. (
  • Liver transplantation was necessary in the three patients with cystic fibrosis because of portal hypertension secondary to either hepatic fibrosis or established cirrhosis in addition to their advanced lung disease. (
  • Three of the four patients were alive at 20, 50, and 100 months after transplantation (one patient with cystic fibrosis died on day 16 of pneumonia) with well-preserved pulmonary function (forced expiratory volume in 1 second 110%, 49%, and 100% predicted, respectively), normal hepatic function and New York Heart Association class 1 performance status. (
  • The most common indications for transplantation in children overall are cystic fibrosis (CF) and idiopathic pulmonary hypertension (PH). (
  • A 19-year-old cystic fibrosis patient with a history of diabetes underwent double lung transplantation. (
  • A 26-year-old cystic fibrosis patient underwent double lung transplantation with a troubled course and a long stay in the intensive care unit and a secondary neuropathy. (
  • Learn about cystic fibrosis, a genetic disorder that affects the lungs, pancreas, and other organs, and how to treat and live with this chronic disease. (
  • 5) In young patients with cystic fibrosis who are being considered for bilateral lung transplantation, CT has limited utility and has not been shown to change the surgical approach and, thus, may be omitted in this limited circumstance. (
  • A 48-year-old woman with cystic fibrosis and a previous left pneumonectomy had surgery planned for single lung transplantation under general anesthesia. (
  • With other lung diseases such as cystic fibrosis, it is imperative that a recipient receive two lungs. (
  • 1983: First successful long-term single lung transplant (Tom Hall) by Joel Cooper (Toronto) 1986: First successful long-term double lung transplant (Ann Harrison) by Joel D. Cooper (Toronto) 1988: First successful long-term double lung transplant for cystic fibrosis by Joel Cooper (Toronto). (
  • A 13-year-old girl with cystic fibrosis was referred for consideration of lung transplantation. (
  • Primary diagnostic indications for lung transplantation in children is cystic fibrosis (CF) pulmonary disease overall, followed by pulmonary hypertension and interstitial lung disease and obliterative bronchiolitis. (
  • Alexander BD, Petzold EW, Reller LB et al (2008) Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex. (
  • Lung transplantation is a treatment option for children and young adults with severe cystic fibrosis (CF), with end-stage lung disease, and other chronic lung diseases. (
  • We provide lung transplantation for a wide variety of patients including those with emphysema/COPD, pulmonary fibrosis and other interstitial lung diseases, cystic fibrosis, pulmonary hypertension, sarcoid, lymphangioleiomyomatosis (LAM), as well as other less common lung diseases. (
  • Diagnosis will indicate that the patient may need a single or double lung replacement due to cystic fibrosis. (
  • Lung transplantation is indicated for end stage pulmonary disease most commonly from cystic fibrosis, alpha 1 antitrypsin disease, Langerhan cell histiocysosis, idiopathic pulmonary arterial hypertension, primary cystic lung disease (lymphangioleiomyomatosis) and COPD/fibrotic lung disease. (
  • In the present study, 4 patients with cystic fibrosis undergoing lung transplantation (from a total of 137) who developed fulminant pseudomembranous colitis are described. (
  • It is concluded that Clostridium difficile colitis may be a difficult diagnosis in patients with cystic fibrosis and follows a fulminant course after lung transplantation. (
  • The outcome of patients with cystic fibrosis aged under 10 years referred for heart-lung transplantation assessment (n=58) was determined and compared with older children (n=109). (
  • Lung transplantation remains the final therapeutic option for end stage lung disease in cystic fibrosis. (
  • Accordingly we assessed the outcome of children with cystic fibrosis aged less than 10 years who had been referred for transplantation assessment and compared this with older children. (
  • We conducted a retrospective review of all children with cystic fibrosis who had been referred since our transplantation programme began in March 1988 until November 1995 (7.7 years). (
  • There are recommended age limitations: single lung transplantation is recommended for individuals who are under 75 years of age, double lung transplantation for those under 65 and heart-lung transplantation for those under 60. (
  • Transplantation surgery is performed with general anesthesia, using an incision on the side of the chest for single lung transplantation or across the sternum or breastbone for double and heart-lung transplantation. (
  • Single lung transplantation is performed via a standard thoracotomy (incision in the chest wall) with the patient under general anesthesia. (
  • Cardiopulmonary bypass (diversion of blood flow from the heart) is not always necessary for a single lung transplant. (
  • The preoperative imaging evaluation is designed to assess the transplant candidate for suitability and to select the most appropriate hemithorax in those considered for single-lung transplantation. (
  • A 52-year-old male with mixed interstitial lung disease/COPD presents for right single-lung transplantation via right thoracotomy and left hemidiaphragm plication. (
  • With some lung diseases, a recipient may only need to receive a single lung. (
  • Following a single-lung transplantation, the patient, identified later as convicted murderer John Richard Russell, survived for 18 days. (
  • Later on that year, she received a single lung transplant in the UK. (
  • In November 2018, Ms. Dwyer was recognized as the world's longest surviving single lung transplant recipient in an event at the Mater Hospital in Dublin. (
  • The researchers also examined the impact of double versus single lung transplant on long-term survival, finding that younger patients who received older donor lungs experienced much better outcomes when a double versus a single transplantation was performed. (
  • Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation. (
  • Since May 2005, the researchers identified 4,134 patients with IPF (of whom 2,010 underwent single-lung and 2,124 underwent double-lung transplantation) and 3,174 patients with COPD, of whom 1,299 underwent single-lung and 1,875 underwent double-lung transplantation. (
  • Like-wise, prognostic models designed to account for the time-varying effect of double-lung transplantation (compared with single-lung transplantation) showed that double- lung transplantation was significantly associated with graft survival among patients with IPF but not among patients with COPD," the authors write. (
  • The Advanced Lung Disease Program at Montefiore and our Department of Cardiothoracic and Vascular Surgery and Department of Medicine bring together teams that include pulmonologists, cardiothoracic surgeons, cardiologists specializing in pulmonary hypertension, radiologists, rheumatologists and other related specialists to provide groundbreaking care for patients with complex medical conditions who have exhausted other treatment options. (
  • The first successful transplant surgery involving the lungs was a heart-lung transplant, performed by Dr. Bruce Reitz of Stanford University in 1981 on a woman who had idiopathic pulmonary hypertension. (
  • Choong CK, Sweet SC, Guthrie TJ, Mendeloff EN, Haddad FJ, Schuler P et al (2005) Repair of congenital heart lesions combined with lung transplantation for the treatment of severe pulmonary hypertension: a 13-year experience. (
  • Most often, the diagnosis includes primary pulmonary hypertension brought on by congenital blood vessel defects that include malformations in the lung. (
  • The immediate post-transplantation course was uncomplicated and shortly afterwards his requirement for nasal desmopressin was reduced, presumably as a result of immunosuppressive therapy. (
  • The ABCB1 variant in rs1045642 was associated with significantly higher Tac concentration, at six months post-transplantation (CT vs. CC). In the MPA analysis, CT patients in ABCC2 rs3740066 presented significantly lower blood concentrations than CC or TT, three months after transplantation. (
  • Protocol biopsy at day 21 post transplantation and screening for serum HLA and non-HLA antibodies by Luminex, LABScreen Autoantibody (One Lambda), before lung transplant and at the moment of the biopsy, were performed. (
  • All invasive infections occurred in the first 6 months post-transplantation, and in some cases in association with periods of refurbishment in the vicinity of our Department. (
  • A higher overall percentage of patients with pre and post-transplantation OP was evidenced in the COPD and CF/BE groups, probably due to the use of corticosteroids in COPD and the risk of osteopenia in CF. A loss of BMD at all localizations and in all the groups, some with statistical significance, was found except for the COPD group. (
  • A patient's LAS is based on risk factors associated with either wait list or post-transplantation mortality. (
  • what effect this may have on post-transplantation outcomes has not been assessed, according to background information in the article. (
  • Two children with advanced lung disease underwent successful cadaveric bilateral lobar lung transplantation, using lungs "cut down" from deceased adult donors - the first reported use of the technique in Australia. (
  • Objective: To report the long-term follow-up of the first living-donor lobar lung transplantation performed in Latin America. (
  • Native upper lobe-sparing living-donor lobar lung transplantation maximizes respiratory function of the donor graft. (
  • OBJECTIVES: Lobar lung transplantation is an option that provides the possibility of transplanting an urgent listed recipient of small size with a size-mismatched donor lung by surgically reducing the size of the donor lung. (
  • We report our short- and long-term results with bilateral lobar lung transplantation (BLLT) and compare it with the long-term outcomes of our cohort. (
  • In the United States, 1,786 people are on the waiting list for a lung transplant, according to the Department of Health and Human Services' Organ Procurement and Transplantation Network. (
  • As part of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee, CDC conducted an investigation. (
  • Donor matching is managed by the Organ Procurement and Transplantation Network (OPTN), in which all organ centers must participate according to Federal Medicare and Medicaid programs. (
  • Lung transplantation involves removal of one or both diseased lungs from a patient and the replacement of the lungs with healthy organs from a donor. (
  • The journal's scope also addresses all aspects of advanced diseases of native thoracic organs, and includes articles with new insights into the immunology, pathogenesis, diagnosis, and management of heart failure and advanced lung disease. (
  • Second, the lung graft, in contrast to all other transplanted organs, is in permanent contact with the external environment and is thus exposed to various inhaled agents, such as fumes, toxins and infectious agents, which may potentially cause local inflammation and trigger acute rejection. (
  • Donors after cardiac death have increasingly provided organs for lung transplantation in Belgium. (
  • It was only after the invention of the heart-lung machine, coupled with the development of immunosuppressive drugs such as ciclosporin, that organs such as the lungs could be transplanted with a reasonable chance of patient recovery. (
  • This approach, while it cannot address the lack of donor organs, may enable us to redress any size bias limiting paediatric lung transplantation. (
  • She was listed for lung transplantation in May 2007, but, given the severity of her lung disease and in the absence of appropriately matched donor organs, the transplant team gave early consideration to cadaveric bilateral lobar transplantation using an adult "oversized" donor. (
  • Their work is part of an ongoing investigation into why and how transplanted organs are rejected by the body so that new and improved methods for protecting a transplanted lung can evolve. (
  • This experimental option, not yet approved by the FDA, may lead to better ways to keep lungs (the most fragile of organs) stable during transplant. (
  • The organization is responsible for the recovery of organs and tissue for medical transplantation in the service area, as well as for professional and public education on organ and tissue donation. (
  • Out of all the organs in the body the lungs are the most sensitive,' said Prof Andrew Fisher of Newcastle. (
  • Once completed, the cardiac chambers are deaired as the organs fill with the patient's blood that is diverted away from the heart and lung machine. (
  • The key problem in organ transplantation remains the shortage of available donor organs. (
  • However, it is often perceived that transplantation is not a viable option for younger children because of difficulties in obtaining suitably sized donor organs. (
  • Complications of lung transplantation include rejection of the transplanted lung and infection. (
  • ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. (
  • Hypoxic gene expression of donor bronchi linked to airway complications after lung transplantation. (
  • Although disease-related complications are frequent, lung transplantation can be a valuable therapy for patients with end-stage lymphangioleiomyomatosis. (
  • Despite advances in current medical therapeutics, the overall mortality of acute lung injury remains as high as 40 percent, and even people who survive may suffer from certain respiratory complications. (
  • Adequate pain control is essential following lung transplantation to reduce patient stress and minimize perioperative complications. (
  • Most transplant surgeries are now performed without using the heart-lung bypass machine, sparing patients from associated postoperative complications. (
  • However, because of surgical and anesthesia innovations, most of the Program's lung transplant patients do not require the assistance of the by-pass machine, thereby reducing certain potential post-operative complications. (
  • Lung Ultrasound in the Assessment of Pulmonary Complications After Lung Transplantation. (
  • Aside from dealing with complications, patients requiring lung transplantation face surmountable problems. (
  • Postoperative surgical complications, lung function tests, late complications and survival were analyzed. (
  • Percutaneous closure of coronary artery fistula prior to lung transplantation is a safe and effective option that reduces the risk associated with volume overload, coronary steal and other complications encountered in patients with this anomaly. (
  • The Official Publication of the International Society for Heart and Lung Transplantation , The Journal of Heart and Lung Transplantation brings readers essential scholarly and timely information in the. (
  • The Official Publication of the International Society for Heart and Lung Transplantation , The Journal of Heart and Lung Transplantation brings readers essential scholarly and timely information in the field of cardiopulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. (
  • The Journal of Heart and Lung Transplantation has an Impact Factor of 5.611 and is ranked 2nd of 26 journals in Transplantation category, 6th out of 53 journals in the Respiratory System category, and 17th of 125 journals in Cardiac and Cardiovascular Systems category in the 2013 Journal Citation Reports®, published by Thomson Reuters. (
  • Journal of Heart and Lung Transplantation , Vol. 13 , 276 - 281. (
  • Now in its 18th year of continuous publication, The Journal of Heart and Lung Transplantation , the official publication of the International Society for Heart and Lung Transplantation , brings readers essential clinical information about the rapidly evolving field of intrathoracic transplantation, support, and replacement. (
  • The Journal of Heart and Lung Transplantation is a monthly peer-reviewed medical journal covering heart and lung transplantation. (
  • RxPG] New research published in the March issue of the Journal of the American College of Surgeons suggests that lung transplantation should be used with caution in patients older than 60 years and that the procedure is associated with high rates of mortality after one year in patients 70 and older. (
  • Abstract: Objective: Pulmonary retransplantation remains controversial due to the increased morbidity and mortality compared with primary lung transplantation. (
  • increased mortality in the P. aeruginosa -infected BMT mice correlates with increased bacterial burden in the lungs as well as increased systemic dissemination. (
  • Given the considerable risks associated with lung transplantation, including a mortality rate that approaches 50 percent at five years, this option should be reserved for patients whose lung disease poses a significant risk of short-term mortality. (
  • Respiratory failure that requires mechanical ventilation or extracorporeal life support (ECLS) prior to transplantation is a risk factor for increased short-term post-transplant mortality. (
  • After lung transplantation, the 30-day mortality decreased from 24% in the 1997-2004 group to 6% in the 2005-2010 group (P = .007). (
  • The 30-day mortality after lung transplantation improved significantly over time, but the long-term survival remained similar between the two cohorts. (
  • Lung transplantation is an active investigative arena at Michigan Medicine with focus on chronic allograft rejection or bronchiolitis obliterans syndrome (BOS), the primary cause of long term mortality after transplantation. (
  • The benefit of lung transplantation comes in the form of both survival and quality of life. (
  • Pediatric lung transplant is nowadays an accepted therapy in well-selected children with end-stage pulmonary disease, offering prolonged overall survival and better quality of life. (
  • Twelve-year survival of the first living-donor pediatric lung transplantation in Brazil. (
  • Study of psychosocial parameters related to the survival rate of renal transplantation in children. (
  • Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (
  • A National Institute for Heath Research Study will now assess survival in recipient patients the first 12 months after transplant with EVLP-improved lungs comparable to that achieved with standard donor lungs. (
  • Among this group of younger patients who received older donor lungs, there was no significant difference in 5-year survival when compared to patients who received lungs from younger donors. (
  • Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival. (
  • Lung transplantation offers patients with advanced, debilitating, and often life-threatening lung disease the possibility of extended survival, improved functional status, and enhanced quality of life. (
  • Collected statistical information includes outcome data, survival data, and risk factor data segregated into subgroups according to various demographic criteria as well as the type of transplant (heart/heart-lung/lung). (
  • Lung Transplantation Survival Rates Drop? (
  • However, national and local statistics show that 55 percent of lung transplantation patients survive after five years, and it indicates a drop in survival rates. (
  • The National Heart Lung and Blood Institute report that the survival rate of double lung transplant is better than a single transplant, which translates to a survival rate of 6.6 and 4.6 years respectively. (
  • Long-term survival after lung transplantation (LTx) is hampered by development of chronic lung allograft dysfunction (CLAD). (
  • Variables associated with graft survival included undergoing transplantation at a high-performing center, undergoing transplantation at a moderate- or high- volume transplant center, receiving a locally allocated organ, and donor-recipient race match (in patients with IPF). (
  • Abstract: Objective: Cardiopulmonary bypass (CPB) support is required in some lung transplantation (LTX) operations. (
  • Abstract: Background: Extracorporeal membrane oxygenation (ECMO) is currently accepted in lung transplantation either to bridge patients to transplantation or to treat postoperatively arising severe primary graft failure. (
  • article{01394bb3-6dff-4aca-b82a-69f65324d8ed, abstract = {Chronic bodily pain after lung transplantation has received little attention. (
  • Treatment with immunosuppressive medication is begun to prevent rejection of the transplanted lung by the patient's immune system. (
  • we practice in Boston, where she ultimately underwent a Although this patient's isolate was resistant to the anti- bilateral lung transplant from a high-risk donor without in- microbial drugs she had received, her symptoms ultimately duction immunosuppression. (
  • From complex cardiac surgery for patients experiencing lung failure and other pulmonary issues, to lung surgery required as part of a patient's cancer treatment, our team of highly-trained specialists have the clinical expertise needed to ensure you the care you need in a leading edge and collaborative environment. (
  • The patient's lung or lungs are removed and the donor lungs are stitched into place. (
  • Lung transplantation, or pulmonary transplantation, is a surgical procedure in which a patient's diseased lungs are partially or totally replaced by lungs which come from a donor. (
  • Despite the severity of a patient's respiratory condition, certain pre-existing conditions may make a person a poor candidate for lung transplantation: Concurrent chronic illness (e.g., congestive heart failure, kidney disease, liver disease) Current infections, including HIV and hepatitis However, more and more often, hepatitis C patients are both being transplanted and are also being used as donors if the recipient is hepatitis C positive. (
  • New immunological surveillance techniques are now being developed at Columbia to enable the diagnosis of more subtle forms of rejection earlier than ever before, which ultimately could improve a lung transplant patient's quality and length of life. (
  • During a lung transplant, the chest is opened to reveal the heart, lungs, and major blood vessels (A). Inferior and superior pulmonary veins and pulmonary artery are separated, and lung is removed (B). The bronchus of the donor lung is connected to the patient's existing bronchus (C). The pulmonary artery is attached (D), and the pulmonary vein and other blood vessels are also connected (E). (
  • Major blood vessels are severed, and the heart is removed (B). Bronchus and blood vessels leading to the lung are severed, and the lung is removed (C). Donor heart and lung are placed in the patient's the chest cavity (D). They are sutured to their appropriate connections, and the heart is restarted before the patient is taken off the heart-lung machine (E). (
  • Under general cardiac anesthesia, an incision is made in the patient's chest to access the heart and lungs. (
  • In addition, other factors that should be considered include the clinical trajectory of the patient's disease (i.e., stable vs. deteriorating), functional status, quality of life, and the patient's willingness to accept the risks, uncertainties, and commitments of transplantation. (
  • Pediatric lung transplantation: indications and outcomes. (
  • Surgery outcomes were compared with 116 patients who received conventional donor lungs. (
  • Here, we review NK cells, their diverse receptors and the mechanisms through which NK cells are postulated to mediate important lung transplant clinical outcomes. (
  • It examines the operational principles which underpin successful lung transplantation and shows how an evidenced based approach combined with wisdom borne of experience leads to better outcomes in day-to-day management. (
  • Focused on simplicity and elegance of style with ample visual images, this book provides a unique overview of trends and strategies for the best outcomes in lung transplantation. (
  • These studies will ultimately provide more successful lung transplant outcomes. (
  • CHICAGO (November 9, 2017) - With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery . (
  • Founded in 1964, The Society of Thoracic Surgeons is a not-for-profit organization representing more than 7,400 cardiothoracic surgeons, researchers, and allied health care professionals worldwide who are dedicated to ensuring the best possible outcomes for surgeries of the heart, lung, and esophagus, as well as other surgical procedures within the chest. (
  • Reasonable post-transplant outcomes can be achieved with lungs from older donors. (
  • OBJECTIVE: To analyze the outcomes of patients with pulmonary arterial hypertension referred for lung transplantation and determine the changes over time. (
  • CONCLUSIONS: This study demonstrates that BLLT has short- and long-term outcomes comparable with those of standard bilateral lung transplantation. (
  • Successful Pseudomonas aeruginosa eradication improves outcomes after lung transplantation: a retrospective cohort analysis. (
  • Hari R. Mallidi, M.D., of the Baylor College of Medicine, Houston, and colleagues reviewed data from the United Network for Organ Sharing thoracic registry to summarize the contemporary demographics and outcomes in adults with IPF or COPD who underwent single- or double- lung transplantation in the United States between May 2005 and December 2012. (
  • Every lung transplant program in the country depends on the generosity of potential organ donors and their families. (
  • We won't just transplant an organ," said Dr. Shaf Keshavjee, the senior author of the study and director of the Toronto Lung Transplant Program at Toronto General Hospital. (
  • The Lung Transplant Program has also been in the vanguard of improving postoperative care by addressing the most significant risks to lung transplantation patients - rejection of the new "foreign" donor organ(s) and infections. (
  • Additionally, lung transplant program clinical investigators are focusing on identifying specific factors in patients that may help determine the optimal timing of transplantation. (
  • The lung transplant program at UW Medical Center - Montlake was established in 1991 and is the only lung transplant program in the Pacific Northwest. (
  • Our lung transplant program emphasizes a multidisciplinary team approach through all phases of the transplant process. (
  • The surfactant protein deficiencies, other interstitial lung diseases (ILDs), and congenital heart disease are important indications among young children and infants. (
  • Association of the RPA3-UMAD1 locus with interstitial lung diseases complicated with rheumatoid arthritis in Japanese. (
  • During 2018, CDC was notified of a rare case of organ-donor derived transmission of a multidrug-resistant bacteria (OXA-23-producing carbapenem-resistant Acinetobacter baumannii) during lung transplantation. (
  • J Heart Lung Transplant 2018. (
  • Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the diagnosis and management of BOS. (
  • Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important new text, that is essential reading for pulmonologists, primary care practitioners, respiratory care practitioners and clinical researchers. (
  • McKane BW, Trulock EP, Patterson GA, Mohanakumar T. Lung transplantation and bronchiolitis obliterans: an evolution in understanding. (
  • The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of itacitinib in participants with post-lung transplant bronchiolitis obliterans syndrome (BOS). (
  • Benden C (2012b) ECMO use as a bridge to pediatric lung transplantation. (
  • Benden C, Edwards LB, Kucheryavaya AY et al (2012a) The Registry of the International Society for Heart and Lung Transplantation: fifteenth official pediatric lung and heart-lung transplantation report - 2012. (
  • Discusses the waiting period for pediatric lung transplantation. (
  • Comments on a study which describes pediatric lung transplantation. (
  • Aurora P, Edwards LB, Kucheryavaya AY, Christie JD, Dobbels F, Kirk R et al (2010) The registry of the international society for heart and lung transplantation: thirteenth official pediatric lung and heart-lung transplantation report-2010. (
  • Due to no effective therapies for obliterative bronchiolitis, the leading cause of death in lung transplant patients, there has been an intensive search for pre-clinical models that replicate obliterative bronchiolitis. (
  • The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. (
  • Lung transplantation (LTx) is a treatment option for infants and children with untreatable and otherwise fatal pulmonary diseases. (
  • Patients who have diseases or conditions that may make them more susceptible to organ rejection are not selected for lung transplant. (
  • 0.05) mean spine and femoral BMD than patients with COPD or other lung diseases both before and after LTx. (
  • Nevertheless, considerable osteoporosis was present in the patients with COPD and other lung diseases before and after LTx. (
  • The research group works with registry based clinical studies and with translational studies in the field of lung transplantation and interstitial and inflammatory pulmonary diseases. (
  • Lung transplantation has been the gold-standard treatment for a variety of end-stage lung diseases, but candidate selection varies greatly among transplantation centers. (
  • In the end stage of various lung diseases, transplantation is the last remaining option for treatment, and it can both prolong life and improve its quality. (
  • What Infectious Diseases are Important to Consider in Transplantation Patients? (
  • Heart-lung and concurrent liver transplantation is a feasible and successful procedure with a satisfactory long-term outcome in selected patients with advanced pulmonary and hepatic disease. (
  • This score is calculated using objective criteria that predict how serious their disease is and the probability of their getting benefit from a lung transplant. (
  • Montefiore's Advanced Lung Disease Program is home to a team of nationally recognized specialists with extensive lung transplant experience. (
  • Learn more about the Advanced Lung Disease Program at Montefiore. (
  • Many candidates for this procedure have end-stage fibrotic lung disease, are dependent on oxygen therapy , and are likely to die of their disease in 12 to 18 months. (
  • Patients with emphysema or chronic obstructive pulmonary disease (COPD) should be under 60 years of age, have a life expectancy without transplantation of two years or less, progressive deterioration, and emotional stability in order to be considered for lung transplantation. (
  • the results measure the progress of the lung disease. (
  • For many patients with end-stage lung disease, lung transplant is the only option available, and it offers the chance for their quality of life to be significantly improved. (
  • Important considerations include the presence or absence of suspicious lung nodules, the presence or absence of pleural disease, or the presence of any other anatomic features that may impact surgical technique and differential perfusion. (
  • Our experience of successful treatment for this patient indicates that it's feasible approach to carry out bilateral allogeneic lung transplantation together with heart defect repair for end-stage congenital heart disease. (
  • Lymphangioleiomyomatosis is a rare disease of unknown origin that usually leads to progressive deterioration of lung function and eventual death from respiratory failure. (
  • For patients with end-stage lung disease, lung transplantation offers hope for a second chance at life. (
  • As the disease progresses there may result a combination of fibrosis and focal emphysema culminating in the development of honeycomb lung. (
  • We report a case of a young man transplanted for Langerhans' cell granulomatosis in whom there was documented evidence of recurrence of disease in the transplanted lung which responded to treatment with cyclophosphamide. (
  • During the last two decades lung transplantation (LTx) has become a life-saving intervention for patients presenting with end-stage respiratory disease. (
  • Lung transplantation is the therapeutic measure of last resort for patients with end-stage lung disease who have exhausted all other available treatments without improvement. (
  • In 1988, Vera Dwyer, a woman from County Sligo in Ireland, was diagnosed with an irreversible, chronic and fibrotic lung disease. (
  • The National Heart, Lung, and Blood Institute's 2014 evidence-based guideline for sickle cell disease -management states additional research is needed before investigational curative the. (
  • Discussion Transplantation is not a common problem for primary care physicians but when a child's disease has progressed to end-stage organ failure, transplantation can be the only treatment available. (
  • Lung transplantation is now an established treatment for patients with severe end-stage lung or pulmonary vascular disease. (
  • in Europe, over two-thirds of children suffer with CF. Today, the ISHLT has international consensus guidelines in place, including general guidance on the selection of pediatric candidates and disease-specifics on referral and timing for listing for lung transplantation. (
  • Heart, heart-lung, and lung transplantation have become accepted modalities for treatment in children with serious cardiopulmonary disease. (
  • Specialized multidisciplinary programs are able to provide alternatives to transplantation for many patients as well as help treat other important medical problems that develop or co-exist in patients with advanced lung disease. (
  • Patients at the NewYork-Presbyterian Center for Lung Disease and Transplantation at Columbia University Medical Center benefit from numerous advances in surgery. (
  • While lung transplant is not a cure for lung disease, it has been shown to have an impressive record in prolonging life among patients with end-stage lung disease: 50 percent of patients live another five years, and 20 percent live another 10 years. (
  • Our multidisciplinary team 1 of lung transplant physicians are experienced in all manner of advanced lung disease. (
  • This organization is working to save lives by improving lung health and preventing lung disease through research, education and advocacy. (
  • CF is the most common underlying disease that may require a lung transplant among children, adolescents, and young adults. (
  • Bronchopulmonary dysplasia or chronic lung disease, CLD (This is a general term for long-term respiratory problems in premature babies resulting from lung injury to babies who must use a mechanical ventilator and oxygen for breathing. (
  • From September 1993 to December 2000,71 patients with end-stage lung disease received lung transplantation. (
  • Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive damage of lung structure and decline in lung function.This study intends to carry out an open, single-center, non-randomized, self control phase I clinical trial. (
  • Van Muylem A, Gevenois PA, Kallinger E, Bankier AA, Knoop C, Verleden G, Estenne M. Single-breath test in lateral decubitus reflects function of single lungs grafted for interstitial lung disease. (
  • Disease-specific guidelines for referral of patients to a lung transplant center, and for active listing for transplantation, are shown in Table I . These guidelines are drawn from consensus expert opinion based on disease-specific prognostic data. (
  • Dr David Weill, director of Stanford's Center for Advance Lung Disease did his first lung operations in the 90s. (
  • (5) describe the extent of RV and left ventricular remodeling after lung transplantation for advanced lung disease (9) . (
  • BACKGROUND: Lung transplantation is an established treatment for patients with end-stage lung disease. (
  • Twelve patients on the provisional list are still undergoing reassessments, and three have died of respiratory failure after unpredictable precipitous deterioration of their lung disease. (
  • In effect, the new technique, called ex vivo lung perfusion (EVLP) cleans the lungs then attaches them to a modified heart-lung bypass machine that pumps a specialised nutrient liquid through, while at the same time providing the lungs with oxygen via a breathing machine. (
  • Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion. (
  • Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. (
  • Ex vivo lung perfusion (EVLP) is a technique developed to counteract the increased risk which follows. (
  • Ex vivo lung perfusion (EVLP) is a technique developed to counteract this increased risk in two ways: first, EVLP improves the method of preserving donor lungs while outside the body. (
  • The Lung Assist for ex vivo lung perfusion (figure 1) is developed by Organ Assist (Groningen, The Netherlands) based on proprietary organ perfusion techniques, in close cooperation with the thoracic surgery department of the University Medical Center Groningen (Groningen, the Netherlands). (
  • Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. (
  • Boehler A, Vogt P, Zollinger A, Weder W, Speich R (1996) Prospective study of the value of transbronchial lung biopsy after lung transplantation. (
  • Harms A, Fuehner T, Warnecke G, Haverich A, Gottlieb J, Trummer A. Epithelial and erythrocyte microvesicles from bronchoalveolar lavage fluid Are elevated and associated with outcome in chronic lung allograft dysfunction. (
  • We conducted a retrospective study by questionnaire of 34 patients, treated at 16 transplantation centers, who underwent lung transplantation for end-stage lymphangioleiomyomatosis between 1983 and 1995. (
  • Ventilation perfusion scan (lung scan, V/Q scan) is a test that compares right and left lung function. (
  • About 85% of lungs made available for donation are not used due to tissue damage that potentially could be repaired with perfusion or other techniques. (
  • Lungs, however, provide a unique opportunity because they are greatly needed and appear so amenable to perfusion treatment, said John Dark, a professor of cardiothoracic surgery at Newcastle University, U.K., and president of the International Society for Heart & Lung Transplantation. (
  • Keshavjee and his team used the Toronto XVIVO Lung Perfusion System, which was designed for this purpose. (
  • Researchers treated 23 sets of lungs that were impaired in some manner - and would have been rejected for transplant - with perfusion for four hours and transplanted 20 of them that looked viable after the treatment. (
  • The perfusion technique essentially repairs damage caused by swelling or inflammation in the lung, Dark said. (
  • Antegrade pulmoplegia was started with 2.8L Perfadex solution while the lungs were ventilated with 50% inspired oxygen, followed by retrograde flush with one additional liter of the same perfusion solution after the heart was extracted. (
  • Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. (
  • Instead of having to survive in a cold static solution, the lungs are continuously perfused with warm optimized perfusion solution and ventilated. (
  • Organ Assist successfully introduced the Lung Assist, and other organ perfusion devices, worldwide and continues to innovate in the field of organ perfusion and transplantation. (
  • We evaluated SNPs in genes that have previously shown correlations in other kinds of solid organ transplantation, namely ABCB1 and CYP3A5 genes with tacrolimus (Tac) and ABCC2 , UGT1A9 and SLCO1B1 genes with mycophenolic acid (MPA), during the first six months after lung transplantation (51 patients). (
  • was possible to expand to fit the lung transplantation context and a new contextual definition of post-transplant recovery after solid organ transplantation was developed. (
  • The thoracic team then opened pleural cavities and quickly inspected both lungs before topical cooling with ice-cold saline was started. (
  • Thoracic Organ Transplantation in Children: The State of Heart, Heart-Lung, and Lung Transplantation. (
  • Thoracic surgeons remove small wedges of damaged lung tissue in order to help the remaining lung tissue function more efficiently. (
  • This multicenter, cross-sectional study is a part of the Swedish national study: Self-management after thoracic transplantation (SMATT). (
  • The ISHLT International Registry for Heart and Lung Transplantation was established to provide on-going up-to-date information on the thoracic organ transplant experience around the world. (
  • 1 The only major changes since this 1991 report are that children are now assessed on a day care basis and that previous thoracic surgery is no longer an absolute contraindication for transplantation. (
  • Close to a third of those waiting for a lung transplant at any one time will never be matched with a donor organ, meaning that many patients who would benefit from a lung transplant will die before suitable donor lungs are identified. (
  • Once OPTN receives the data from local hospitals, people waiting for a lung transplant are placed on a waiting list and given a "status" code. (
  • The U.S. Organ Procurement & Transplant Network (OPTN) reports that 1,399 people currently are waiting for a lung transplant in the United States. (
  • The overall median waiting time for candidates on the wait list is 4 months, while more than 200 people die annually waiting for a lung transplant, according to an OPTN report. (
  • Replacing cardiopulmonary bypass with extracorporeal membrane oxygenation in lung transplantation operations Bittner, Hartmuth B. (
  • After receiving a lung transplant, patients must be on lifelong immunosuppression to prevent rejection of the transplanted lung. (
  • Routine triple therapy immunosuppression (cyclosporin A, azathioprine, prednisolone) was maintained until 12 months after transplantation but azathioprine was then discontinued due to a persistently low white cell count. (
  • Other lung topics covered are living donation, recent surgical advances and changes in immunosuppression regimens. (
  • The patient was transferred to the tertiary care hospital in which we practice in Boston, where she ultimately underwent a bilateral lung transplant from a high-risk donor without induction immunosuppression. (
  • Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. (
  • Neither patient developed allograft rejection, and lung function gradually improved ( Box 2 ). (
  • The screening of non-HLA and HLA antibodies could help to identify patient at risk of lung-allograft rejection. (
  • Our observations of lymphatic phenotype after heart and lung transplantation in human patients are the first of their kind and provide the evidence, that acute allograft rejection is associated with significant changes of lymphatic endothelial phenotype. (
  • The native diseased lung or lungs are removed from the recipient while the donor lung is being recovered. (
  • The new lung is then attached to the recipient by way of three anastomosis or connections, one for the bronchus, one for the pulmonary artery and one for the pulmonary veins. (
  • Patients on a recipient list must be available and ready to come to the hospital immediately when a donor match is found, since the life of the lungs outside the body is brief. (
  • The heart, lung, and supporting structures are transplanted into the recipient at the same time. (
  • For decades, heart and lung transplant surgeons have followed a strict directive: Get the donor organ into the recipient as soon as possible. (
  • Preoperative evaluation of the lung transplant recipient allows for optimal planning of intraoperative ventilation, hemodynamic support, and the need for extracorporeal support. (
  • Finally, the lung graft contains a huge amount of donor antigen-presenting cellsconstantly processing and presenting HLA alloantigens to recipient lymphocytes that initiate a process of immune recognition. (
  • Donor-recipient matching in lung transplantation: which variables are important? (
  • Donor to recipient (D/R) matching in lung transplantation (LTx) is usually directed by blood group (identity or compatibility) and predicted total lung capacity (pTLC) based on height and age. (
  • Lungs were then explanted, packed and transported to the recipient hospital in the standard way. (
  • There are certain requirements for potential lung donors, due to the needs of the potential recipient. (
  • The researchers are also investigating methods for preserving donor lungs for a longer period of time before they must be transplanted into the recipient. (
  • The donor left lung is prepared for the recipient by the attachment of cuffs. (
  • In the case of a double lung transplant, the procedure is repeated for the second lung in the other side of the chest. (
  • He deteriorated despite prednisolone, oxygen, diltiazem and warfarin and underwent bilateral sequential lung transplantation. (
  • Previous data suggested that outcome in small children with cadaveric renal transplantation might be improved with sequential therapy. (
  • Clamshell sternotomy is the standard incision for sequential bilateral lung transplantation. (
  • Newswise - A study published in this month's Anesthesiology highlights the potential of cell-based therapies for the treatment of acute lung injury and acute respiratory distress syndrome (ARDS). (
  • Acute lung injury and acute respiratory distress syndrome continue to be major causes of death in seriously ill patients," said Dr. Lam. (
  • By sparing the respiratory muscles, median sternotomy is probably less invasive and preserves lung function. (
  • Due to progressive dyspnea and recurrent respiratory infection, she could not maintain her normal daily life without lung transplantation. (
  • We studied the association between systemic inflammation, markers for bone turnover and recent weight change in underweight (n=48) and normal-weight patients (n=23) candidates for lung transplantation where the majority (56%) had COPD. (
  • The cumulative dose of corticosteroids after transplantation was higher in the ILD group followed by the COPD group. (
  • The interaction between diagnosis (COPD or IPF) and treatment type (single- and double-lung transplantation) was significant, supporting the finding that the benefit of double-lung transplantation may differ by diagnosis. (
  • Young patients with end-stage silicosis may be candidates for lung or heart-lung transplantation. (
  • While there are no specific age or weight cutoffs for lung-transplant candidates, the team puts together the entire picture of the person's health and prognosis to determine his or her suitability to receive a transplant. (
  • Our findings suggest that lung transplantation remains a viable option for appropriate candidates younger than age 70. (
  • In this previous study the Johns Hopkins researchers looked at factors that create positive results in a 60-plus patient population, which has typically been regarded as not being the best candidates for lung transplantation. (
  • Cytokines, bone turnover markers and weight change in candidates for lung transplantation. (
  • Patients who are limited in daily activity, as defined by their doctors, and have a limited life expectancy, are candidates for heart-lung transplantation. (
  • Dr. Whited explained that while the use of extended criteria donor lungs varies from program to program, most surgeons should be willing to accept non-ideal donors, especially those who are older but otherwise good candidates. (
  • A lung function test showed severely obstructive ventilation dysfunction. (
  • After 72 hours, 15% of the patients who received treated lungs suffered primary graft dysfunction, a potentially fatal complication, compared with 30% of the patients in the control group. (
  • There are factors which absolutely contraindicate (rule out) heart-lung transplantation, including multiple organ system dysfunction, current substance abuse, bone marrow failure, active malignancy, and HIV infection. (
  • Between 01/2007-12/2009 in Leuven 17 isolated lung transplantations were performed from cardiac death donors, including four after euthanasia, Dirk van Raemdonck and colleagues (Leuven) report. (
  • Initial Experience with Transplantation of Lungs Recovered from Donors after Euthanasia. (
  • Anyanwu AC, Banner NR, Radley-Smith R, Khaghani A, Yacoub MH (2002) Long-term results of cardiac transplantation from live donors: the domino heart transplant. (
  • Damaged lungs from organ donors could soon be made viable for transplantation owing to a new technique. (
  • The majority of lungs that are transplanted come from deceased organ donors. (
  • The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report--2010. (
  • This new retrospective study examined 8,363 adult patients who underwent lung transplantation between 1999 and 2006. (
  • I read with interest the article by Morton et al, summarising their impressive results of lung transplantation in adolescents treated in an adult hospital. (
  • Orthotopic lung transplantation in rats was first reported by Asimacopoulos and colleagues in 1971 1 . (
  • Two patients who had fatal hyperammonemia after orthotopic lung transplantation. (
  • Of the 100 patients listed for lung transplantation, 57 underwent bilateral lung transplantation, 22 underwent heart-lung transplantation, 18 died while waiting, and 3 were still waiting. (
  • In 1983, lung transplantation became a clinical reality and the number of procedures performed is steadily increasing. (
  • A forum that includes all aspects of pre-clinical and clinical science of the failing heart and lung. (
  • This book presents a clear and concise summary of the clinical tenets of lung transplantation with an update on recent developments in the field. (
  • Through their scientific and clinical research and participation in multi-center clinical trials, the Center's physicians contribute to the advancement of lung transplantation by investigating new immunosuppressive drugs and exploring possible drug combinations to increase the longevity of the transplanted organ while decreasing side effects associated with therapy. (
  • We analysed prevalence, clinical presentation, treatment options and outcome of invasive Aspergillus infections in our population of patients submitted to lung transplantation. (
  • Patients will receive 10^6 (1 million)/Kg/person cells of clinical grade lung stem cells (LSCs)injected via fiberoptic bronchoscopy after fully lavage of the localized lesions. (
  • The UMCG has implemented EVLP in clinical practise and increased their number of lung transplantations significantly. (
  • Variation between multidisciplinary tumor boards in clinical staging and treatment recommendations for patients with locally advanced non-small cell lung cancer. (
  • Approachable and easily digested, this book will be a go-to resource for professionals seeking a succinct and well-illustrated guide to this growing area of surgical transplantation. (
  • Surgical refinements have reduced the size of the incision required during transplantation. (
  • A lung transplant is a surgical procedure performed to remove one or both diseased lungs from a patient and replace it with a healthy one from another person. (
  • The operation requires surgical replacement of either one or two badly diseased lungs from a human donor. (
  • Clamshell sternotomy wires and bilateral hilar surgical clips in keeping with bilateral lung transplantation. (
  • If bypass is necessary, it involves re-routing of the blood through tubes to a heart-lung bypass machine. (
  • Throughout the surgery, a heart-lung bypass machine is on standby in case it becomes necessary to use this equipment to temporarily take over the work of the heart and lungs by pumping and oxygenating the blood. (
  • Burton CM, Iversen M, Scheike T, Carlsen J, Andersen CB (2008) Minimal acute cellular rejection remains prevalent up to 2 years after lung transplantation: a retrospective analysis of 2697 transbronchial biopsies. (
  • Therefore, the aim was to provide a multidimensional assessment of self-reported chronic pain 1-5 years after lung transplantation and its relationship with self-reported psychological general well-being (PGWB) and self-efficacy. (
  • Chronic bodily pain is a common and serious symptom up to five years after lung transplantation. (
  • In older children, CF is the most frequent indication for lung transplantation. (