Primary Graft Dysfunction
Bone Marrow Transplantation
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation
Collagen Type V
Tissue and Organ Procurement
Islets of Langerhans Transplantation
Extracorporeal Membrane Oxygenation
Lung Diseases, Interstitial
Respiratory Function Tests
Graft vs Host Disease
Cord Blood Stem Cell Transplantation
Idiopathic Pulmonary Fibrosis
Bronchoalveolar Lavage Fluid
Carcinoma, Non-Small-Cell Lung
Organ Dysfunction Scores
Peripheral Blood Stem Cell Transplantation
Forced Expiratory Volume
Fetal Tissue Transplantation
Pulmonary Veno-Occlusive Disease
Blood Group Incompatibility
Pulmonary Disease, Chronic Obstructive
Acute Lung Injury
Total Lung Capacity
Organ Preservation Solutions
Tissue and Organ Harvesting
Mesenchymal Stem Cell Transplantation
Severity of Illness Index
Delayed Graft Function
Health Care Rationing
Tomography, X-Ray Computed
Lung Diseases, Obstructive
Proportional Hazards Models
Brain Tissue Transplantation
Lung Volume Measurements
Bronchial artery perfusion scintigraphy to assess bronchial artery blood flow after lung transplantation. (1/1390)The bronchial arterial system is inevitably interrupted in transplanted lungs when removing the organs from the donor, but it can be reestablished by direct bronchial artery revascularization (BAR) during implantation. The purpose of this study was to visualize and quantify the distribution of bronchial artery perfusion after en bloc double lung transplantation with BAR, by injecting radiolabeled macroaggregated albumin directly into the bronchial artery system. METHODS: BAR was performed using the internal mammary artery as conduit. Patients were imaged 1 mo (n = 13) or 2 y (n = 9) after en bloc double lung transplantation with BAR. Immediately after bronchial arteriography, 100 MBq macroaggregated albumin (45,000 particles) were injected through the arteriographic catheter. Gamma camera studies were then acquired in the anterior position. At the end of imaging, with the patient remaining in exactly the same position, 81mKr-ventilation scintigraphy or conventional intravenous pulmonary perfusion scintigraphy or both were performed. Images were evaluated by visual analysis, and a semiquantitative assessment of the bronchial arterial supply to the peripheral parts of the lungs was obtained with conventional pulmonary scintigraphy. RESULTS: The bronchial artery scintigraphic images showed that the major part of the bronchial arterial flow supplied central thoracic structures, but bronchial artery perfusion could also be demonstrated in the peripheral parts of the lungs when compared with conventional pulmonary scintigraphy. There were no differences between scintigrams obtained from patients studied 1 mo and 2 y post-transplantation. CONCLUSION: Total distribution of bronchial artery supply to the human lung has been visualized in lung transplant patients. This study demonstrates that this nutritive flow reaches even the most peripheral parts of the lungs and is present 1 mo as well as 2 y after lung transplantation. The results suggest that bronchial artery revascularization may be of significance for the long-term status of the lung transplant. (+info)
Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. (2/1390)Human cytomegalovirus (HCMV) infection was monitored retrospectively by qualitative determination of pp67 mRNA (a late viral transcript) by nucleic acid sequence-based amplification (NASBA) in a series of 50 transplant recipients, including 26 solid-organ (11 heart and 15 lung) transplant recipients (SOTRs) and 24 bone marrow transplant recipients (BMTRs). NASBA results were compared with those obtained by prospective quantitation of HCMV viremia and antigenemia and retrospective quantitation of DNA in leukocytes (leukoDNAemia). On the whole, 29 patients were NASBA positive, whereas 10 were NASBA negative, and the blood of 11 patients remained HCMV negative. NASBA detected HCMV infection before quantitation of viremia did but after quantitation of leukoDNAemia and antigenemia did. In NASBA-positive blood samples, median levels of viremia, antigenemia, and leukoDNAemia were significantly higher than the relevant levels detected in NASBA-negative HCMV-positive blood samples. By using the quantitation of leukoDNAemia as the "gold standard," the analytical sensitivity (47.3%), as well as the negative predictive value (68. 3%), of NASBA for the diagnosis of HCMV infection intermediate between that of antigenemia quantitation (analytical sensitivity, 72. 3%) and that of viremia quantitation (analytical sensitivity, 28.7%), while the specificity and the positive predictive value were high (90 to 100%). However, with respect to the clinically relevant antigenemia cutoff of >/=100 used in this study for the initiation of preemptive therapy in SOTRs with reactivated HCMV infection, the clinical sensitivity of NASBA reached 100%, with a specificity of 68. 9%. Upon the initiation of antigenemia quantitation-guided treatment, the actual median antigenemia level was 158 (range, 124 to 580) in SOTRs who had reactivated infection and who presented with NASBA positivity 3.5 +/- 2.6 days in advance and 13.5 (range, 1 to 270) in the group that included BMTRs and SOTRs who had primary infection (in whom treatment was initiated upon the first confirmation of detection of HCMV in blood) and who presented with NASBA positivity 2.0 +/- 5.1 days later. Following antiviral treatment, the durations of the presence of antigenemia and pp67 mRNA in blood were found to be similar. In conclusion, monitoring of the expression of HCMV pp67 mRNA appears to be a promising, well-standardized tool for determination of the need for the initiation and termination of preemptive therapy. Its overall clinical impact should be analyzed in future prospective studies. (+info)
Retransplantation in a patient with cystic fibrosis. (3/1390)A patient with cystic fibrosis is described who requested a third lung transplant. The medical and ethical issues involved are discussed. (+info)
Recurrence of bronchioloalveolar carcinoma in transplanted lungs. (4/1390)BACKGROUND: Bronchioloalveolar carcinoma is a distinctive subtype of typical adenocarcinoma of the lung that tends to metastasize widely throughout the lungs but less commonly elsewhere. Because conventional therapies for intrapulmonary metastatic bronchioloalveolar carcinoma are generally ineffective, we treated seven patients who had intrapulmonary metastatic bronchioloalveolar carcinoma with lung transplantation. METHODS: Seven patients with biopsy-proved bronchioloalveolar carcinoma and no evidence of extrapulmonary disease received transplants of either one or two cadaveric lungs. At transplantation, all native lung tissue was removed and replaced with a donor lung or lungs. The patients received the usual post-transplantation care given at the institution. RESULTS: Four of the seven patients had recurrent bronchioloalveolar carcinoma within the donor lungs; the recurrences appeared from 10 to 48 months after transplantation. All recurrences were limited to the donor lungs. Histologic and molecular analyses showed that the recurrent tumors in three patients originated from the recipients of the transplants. CONCLUSIONS: Lung transplantation for bronchioloalveolar carcinoma is technically feasible, but recurrence of the original tumor within the donor lungs up to four years after transplantation was common. (+info)
Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease. (5/1390)BACKGROUND: Alpha-1 antitrypsin (alpha 1-AT) is the most abundant proteinase inhibitor within the lung. We have recently reported the surprising observation that cystic fibrosis patients with mild to moderate deficiency of alpha 1-antitrypsin have significantly better pulmonary function than non-deficient patients. This study may have been biased as it did not include the most severely affected patients who have died in childhood or those who have undergone orthotopic lung transplantation. The prevalence of alpha 1-antitrypsin deficiency alleles in this most severely affected group of patients with cystic fibrosis was therefore assessed. METHODS: DNA was obtained from neonatal blood spots from children with cystic fibrosis who had died from pulmonary disease and from formalin fixed lung tissue from transplanted cystic fibrosis patients. The common S and Z deficiency alleles of alpha 1-AT were sought by amplification mutagenesis of the appropriate region of the alpha 1-AT gene followed by restriction enzyme digestion with Xmn I and Taq I, respectively. RESULTS: Seventy-nine patients were identified (seven dead, 72 transplanted). Two patients (2.5%) were heterozygous for the Z allele of alpha 1-AT and four (5.1%) were heterozygous for the S allele. This is not significantly different from the incidence in the normal population of 4% and 8% for the S and Z alleles, respectively. CONCLUSIONS: These data support previous findings that deficiency of alpha 1-AT is not associated with more severe pulmonary disease in cystic fibrosis and may be associated with milder lung disease. Further work is needed to clarify the mechanisms underlying the progressive lung damage in cystic fibrosis. (+info)
Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases. (6/1390)The MR imaging findings of fungal spinal osteomyelitis in three recipients of organ transplants showed hypointensity of the vertebral bodies on T1-weighted sequences in all cases. Signal changes and enhancement extended into the posterior elements in two cases. Multiple-level disease was present in two cases (with a total of five intervertebral disks involved in three cases). All cases lacked hyperintensity within the disks on T2-weighted images. In addition, the intranuclear cleft was preserved in four of five affected disks at initial MR imaging. MR features in Candida and Aspergillus spondylitis that are distinct from pyogenic osteomyelitis include absence of disk hyperintensity and preservation of the intranuclear cleft on T2-weighted images. Prompt recognition of these findings may avoid delay in establishing a diagnosis and instituting treatment of opportunistic osteomyelitis in the immunocompromised patient. (+info)
Exogenous surfactant improves survival and surfactant function in ischaemia-reperfusion injury in minipigs. (7/1390)Reperfusion injury is the major cause of early morbidity and mortality after lung transplantation. This complication has been experimentally linked to dysfunction of pulmonary surfactant. Therefore, the hypothesis that reperfusion injury might be preventable by exogenous surfactant treatment was tested. Left lungs of minipigs were exposed to 120 min of ischaemia, and the lungs were then reperfused for up to 7 h. Animals were divided into a control group and a surfactant group (n=5 each). The surfactant group received 50 mg x kg(-1) Alveofact intrabronchially via a bronchoscope at the beginning of the ischaemic period. Bronchoalveolar lavage was performed at baseline before ischaemia and 90 min after reperfusion. Surfactant treatment significantly improved short-term survival. Pulmonary vascular resistance increased markedly in control animals leading to right heart failure and death within 3 h after reperfusion whereas the surfactant-treated animals survived the 7 h observation period. After reperfusion, alveolar accumulation of neutrophils and exuded proteins was present in both groups to the same extent. Surfactant activity after reperfusion deteriorated markedly in the control group but was preserved in the surfactant group. In conclusion, early surfactant treatment alleviates the deterioration of surfactant function and improves survival in this minipig model of ischaemia-reperfusion injury. (+info)
Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cells. (8/1390)The inflammatory pathogenesis in airways of patients with cystic fibrosis (CF) is still unresolved. We demonstrate here that in in situ human DeltaF508 homozygous CF bronchial tissues, submucosal gland cells exhibit an absence of inhibitor factor kappaBalpha (IkappaBalpha) and high levels of chemokine interleukin-8 (IL-8) expression. These results were confirmed by cultured human CF bronchial gland cells in which a lack of cytosolic IkappaBalpha and high levels of constitutively activated nuclear factor kappaB (NFkappaB) associated with an up-regulation of IL-8 production (13-fold increase) were found when compared to non-CF (control) disease bronchial gland cells. We also demonstrated that the isoflavone genistein, a well known CFTR mutant Cl(-) channel stimulator, significantly reduces the endogenous and Pseudomonas aeruginosa lipopolysaccharide-induced IL-8 production in cultured CF bronchial gland cells by increasing cytosolic IkappaBalpha protein levels. Overall, results show that genistein is a potent inhibitor of the activated NFkappaB identified in CF gland cells. This strong inhibition of constitutively activated NFkappaB and the resulting down-regulation of IL-8 production by genistein in the CF gland cells highlights the key role played by cytosolic IkappaBalpha in the regulation of inflammatory processes in CF human airway cells. (+info)
Bronchiolitis obliterans is a chronic lung disease characterized by inflammation and scarring of the small airways (bronchioles) in the lungs. This scarring can lead to narrowing or complete blockage of the bronchioles, making it difficult for air to flow in and out of the lungs. The condition is often caused by exposure to harmful substances, such as cigarette smoke, air pollution, or certain chemicals. Symptoms of bronchiolitis obliterans may include shortness of breath, wheezing, coughing, and chest tightness. Treatment may involve the use of medications to reduce inflammation and open up the airways, as well as oxygen therapy and pulmonary rehabilitation. In severe cases, a lung transplant may be necessary.
Primary graft dysfunction (PGD) is a condition that occurs when a transplanted organ or tissue fails to function properly soon after transplantation. It is a common complication of organ transplantation and can occur in various organs, including the heart, liver, kidney, and lung. PGD is caused by a variety of factors, including ischemia-reperfusion injury, immunological rejection, and infection. Ischemia-reperfusion injury occurs when the transplanted organ is deprived of oxygen and nutrients for a period of time before being reperfused with blood, causing damage to the organ's cells. Immunological rejection occurs when the recipient's immune system recognizes the transplanted organ as foreign and mounts an attack against it. Infection can also cause PGD by damaging the transplanted organ. Symptoms of PGD may include decreased organ function, fever, and inflammation. Treatment for PGD typically involves addressing the underlying cause of the dysfunction, such as administering immunosuppressive drugs to prevent rejection or treating an infection. In severe cases, the transplanted organ may need to be removed and replaced with a new one.
Lung diseases refer to a wide range of medical conditions that affect the lungs and their ability to function properly. These conditions can be acute or chronic, and can range from mild to severe. Some common examples of lung diseases include: 1. Chronic Obstructive Pulmonary Disease (COPD): A group of lung diseases that includes chronic bronchitis and emphysema, characterized by difficulty breathing and shortness of breath. 2. Asthma: A chronic inflammatory disease of the airways that causes wheezing, shortness of breath, chest tightness, and coughing. 3. Pulmonary Fibrosis: A progressive lung disease that causes scarring and thickening of the lung tissue, making it difficult to breathe. 4. Tuberculosis: A bacterial infection that primarily affects the lungs, causing coughing, fever, and weight loss. 5. Pneumonia: An infection of the lungs that can be caused by bacteria, viruses, or fungi, and can cause fever, cough, and difficulty breathing. 6. Emphysema: A lung disease that causes damage to the air sacs in the lungs, making it difficult to breathe. 7. Interstitial Lung Disease: A group of lung diseases that affect the tissue between the air sacs in the lungs, causing difficulty breathing and shortness of breath. 8. Lung Cancer: A type of cancer that starts in the lungs and can spread to other parts of the body. These are just a few examples of the many different types of lung diseases that can affect people. Treatment for lung diseases depends on the specific condition and can include medications, lifestyle changes, and in some cases, surgery.
Cystic Fibrosis (CF) is a genetic disorder that affects the respiratory, digestive, and reproductive systems. It is caused by mutations in the CFTR gene, which codes for a protein that regulates the movement of salt and water in and out of cells. In people with CF, the protein is not functioning properly, leading to the production of thick, sticky mucus in the lungs, pancreas, and other organs. The thick mucus can cause blockages in the airways, leading to chronic lung infections and damage to the lungs over time. It can also affect the pancreas, making it difficult to produce digestive enzymes and leading to malnutrition. In the reproductive system, it can cause infertility in both men and women. CF is a lifelong condition that requires ongoing medical care and management. Treatment typically involves medications to thin the mucus, antibiotics to treat infections, and physical therapy to improve lung function. With proper care, people with CF can lead long and relatively healthy lives, although the condition can still be challenging and require significant lifestyle adjustments.
Postoperative complications are adverse events that occur after a surgical procedure. They can range from minor issues, such as bruising or discomfort, to more serious problems, such as infection, bleeding, or organ damage. Postoperative complications can occur for a variety of reasons, including surgical errors, anesthesia errors, infections, allergic reactions to medications, and underlying medical conditions. They can also be caused by factors such as poor nutrition, dehydration, and smoking. Postoperative complications can have serious consequences for patients, including prolonged hospital stays, additional surgeries, and even death. Therefore, it is important for healthcare providers to take steps to prevent postoperative complications and to promptly recognize and treat them if they do occur.
Collagen Type V is a protein that is found in the extracellular matrix of connective tissues in the human body. It is a component of the fibrillar collagen network, which provides strength and support to tissues such as skin, tendons, ligaments, and bone. Collagen Type V is a heterotrimeric protein, meaning that it is composed of three different chains of collagen, called alpha chains. The three alpha chains of collagen Type V are called alpha 1(V), alpha 2(V), and alpha 3(V). Collagen Type V is known for its unique triple helical structure, which is formed by the winding of the three alpha chains around each other. This structure gives collagen its strength and flexibility. In addition to its structural role in connective tissues, collagen Type V has also been implicated in a number of biological processes, including cell signaling, tissue development, and wound healing. It is also involved in the regulation of blood vessel formation and the development of blood clots. Research has suggested that collagen Type V may play a role in the development of certain diseases, including osteoporosis, atherosclerosis, and certain types of cancer. As a result, there is ongoing interest in understanding the function of collagen Type V and developing therapies that target this protein.
Bronchial diseases refer to a group of medical conditions that affect the bronchi, which are the two tubes that carry air from the trachea (windpipe) to the lungs. These diseases can cause inflammation, narrowing, or blockage of the bronchi, leading to difficulty breathing, coughing, and other respiratory symptoms. Some common bronchial diseases include: 1. Chronic bronchitis: A long-term condition characterized by persistent coughing and production of mucus. 2. Asthma: A chronic inflammatory disorder of the airways that causes wheezing, shortness of breath, and coughing. 3. Emphysema: A progressive lung disease that causes damage to the air sacs in the lungs, making it difficult to breathe. 4. Bronchiectasis: A condition in which the bronchi become enlarged and infected, leading to chronic coughing and production of mucus. 5. Bronchopulmonary dysplasia (BPD): A lung disease that occurs in premature babies and is characterized by abnormal lung development. 6. Chronic obstructive pulmonary disease (COPD): A group of lung diseases that includes chronic bronchitis and emphysema, characterized by chronic airflow obstruction and breathlessness. Treatment for bronchial diseases depends on the specific condition and may include medications, lifestyle changes, and in some cases, surgery.
Pulmonary fibrosis is a chronic lung disease characterized by the scarring and thickening of the lung tissue, which can lead to difficulty breathing and a reduced ability to transfer oxygen from the lungs to the bloodstream. This scarring, or fibrosis, is caused by damage to the lungs, which can be the result of a variety of factors, including exposure to environmental pollutants, certain medications, infections, and autoimmune diseases. Pulmonary fibrosis can be a progressive disease, meaning that the scarring and thickening of the lung tissue can worsen over time, leading to more severe symptoms and a reduced quality of life. Treatment for pulmonary fibrosis typically involves managing symptoms and slowing the progression of the disease, but there is currently no cure.
Lung neoplasms refer to abnormal growths or tumors that develop in the lungs. These growths can be either benign (non-cancerous) or malignant (cancerous). Lung neoplasms can occur in any part of the lung, including the bronchi, bronchioles, and alveoli. Lung neoplasms can be further classified based on their type, including: 1. Primary lung neoplasms: These are tumors that develop in the lungs and do not spread to other parts of the body. 2. Secondary lung neoplasms: These are tumors that develop in the lungs as a result of cancer that has spread from another part of the body. 3. Benign lung neoplasms: These are non-cancerous tumors that do not spread to other parts of the body. 4. Malignant lung neoplasms: These are cancerous tumors that can spread to other parts of the body. Some common types of lung neoplasms include lung adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and small cell carcinoma. The diagnosis of lung neoplasms typically involves a combination of imaging tests, such as chest X-rays and CT scans, and a biopsy to examine a sample of tissue from the tumor. Treatment options for lung neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient.
Hypertension, Pulmonary refers to high blood pressure that affects the blood vessels in the lungs. It is also known as Pulmonary Arterial Hypertension (PAH) or Pulmonary Hypertension (PH). PAH is a rare and serious condition that causes the blood vessels in the lungs to narrow and stiffen, leading to increased blood pressure in the pulmonary arteries. This increased pressure can cause the heart to work harder to pump blood through the lungs, which can lead to heart failure over time. Symptoms of Pulmonary Hypertension may include shortness of breath, fatigue, chest pain, dizziness, and fainting. The condition can be caused by a variety of factors, including genetic mutations, infections, autoimmune disorders, and exposure to certain toxins. Treatment for Pulmonary Hypertension typically involves medications to lower blood pressure and improve blood flow in the lungs, as well as oxygen therapy and in some cases, surgery. Early diagnosis and treatment are important for improving outcomes and reducing the risk of complications.
Lung injury refers to any damage or injury to the lungs, which can be caused by a variety of factors such as infections, physical trauma, chemical exposure, or medical procedures. The severity of lung injury can range from mild to severe, and it can affect different parts of the lungs, including the airways, alveoli, and blood vessels. Some common types of lung injury include: 1. Acute respiratory distress syndrome (ARDS): A severe lung injury that occurs when the lungs become inflamed and unable to function properly, leading to difficulty breathing and low oxygen levels in the blood. 2. Pneumonia: An infection of the lungs that can cause inflammation, fluid buildup, and damage to the alveoli. 3. Pulmonary edema: A condition in which fluid accumulates in the lungs, causing difficulty breathing and shortness of breath. 4. Pulmonary embolism: A blockage of a blood vessel in the lungs, which can cause shortness of breath, chest pain, and other symptoms. 5. Asbestosis: A lung disease caused by exposure to asbestos fibers, which can lead to scarring and inflammation of the lungs. Treatment for lung injury depends on the underlying cause and severity of the injury. In some cases, supportive care such as oxygen therapy or mechanical ventilation may be necessary. In other cases, medications or surgery may be required to treat the underlying cause of the injury.
Interstitial lung diseases (ILDs) are a group of disorders that affect the lungs' interstitium, which is the tissue that lies between the air sacs (alveoli) and the walls of the blood vessels. The interstitium is responsible for providing structural support to the lungs and facilitating gas exchange. ILDs can be classified into several categories based on their underlying cause, such as autoimmune disorders, environmental exposures, genetic disorders, infections, and connective tissue diseases. Some common examples of ILDs include idiopathic pulmonary fibrosis (IPF), sarcoidosis, hypersensitivity pneumonitis, and chronic obstructive pulmonary disease (COPD). The symptoms of ILDs can vary depending on the specific disease and the severity of the condition. Common symptoms include shortness of breath, cough, fatigue, and chest pain. In some cases, ILDs can progress to a point where breathing becomes difficult, and oxygen therapy may be required. Treatment for ILDs depends on the underlying cause and the severity of the condition. In some cases, medications may be used to manage symptoms or slow the progression of the disease. In more severe cases, lung transplantation may be considered as a treatment option.
Pulmonary emphysema is a chronic lung disease characterized by the destruction of the air sacs (alveoli) in the lungs, leading to a loss of elasticity and a decrease in the ability of the lungs to expand and contract properly. This results in difficulty breathing, shortness of breath, and a persistent cough, which may produce mucus or blood. Pulmonary emphysema is typically caused by long-term exposure to cigarette smoke or other irritants, and is a common complication of chronic obstructive pulmonary disease (COPD). It is a progressive disease that can lead to respiratory failure and death if left untreated. Treatment options for pulmonary emphysema include medications to manage symptoms, oxygen therapy, and in severe cases, lung transplantation.
Reperfusion injury is a type of damage that occurs when blood flow is restored to an organ or tissue that has been deprived of oxygen for a prolonged period of time. This can happen during a heart attack, stroke, or other conditions that cause blood flow to be blocked to a particular area of the body. When blood flow is restored, it can cause an inflammatory response in the affected tissue, leading to the release of free radicals and other harmful substances that can damage cells and tissues. This can result in a range of symptoms, including swelling, pain, and organ dysfunction. Reperfusion injury can be particularly damaging to the heart and brain, as these organs are highly sensitive to oxygen deprivation and have a limited ability to repair themselves. Treatment for reperfusion injury may involve medications to reduce inflammation and prevent further damage, as well as supportive care to manage symptoms and promote healing.
Respiratory aspiration is a medical condition that occurs when a person inhales foreign material into their lungs. This can happen when a person is unconscious, has difficulty swallowing, or has a weakened cough reflex, among other reasons. Aspiration can lead to a variety of complications, including pneumonia, lung abscesses, and respiratory failure. Treatment for respiratory aspiration typically involves removing the foreign material from the lungs and providing supportive care to manage any complications that may arise.
Tacrolimus is a medication that is used to prevent the rejection of transplanted organs, such as the kidney, liver, or heart. It is also used to treat certain types of autoimmune diseases, such as rheumatoid arthritis and psoriasis. Tacrolimus works by suppressing the immune system, which helps to prevent the body from attacking the transplanted organ or treating the autoimmune disease. It is usually given as a pill or as a cream or ointment applied to the skin. Side effects of tacrolimus can include nausea, vomiting, diarrhea, headache, and skin rash. It can also cause more serious side effects, such as high blood pressure, kidney problems, and an increased risk of infection. It is important to carefully follow the instructions of your healthcare provider when taking tacrolimus and to report any side effects that you experience.
Bronchomalacia is a condition in which the walls of the bronchi (the airways that carry air from the trachea to the lungs) are weakened and floppy, making them prone to collapse. This can cause difficulty breathing, wheezing, and shortness of breath, especially during exercise or when lying down. Bronchomalacia is most commonly seen in infants and young children, but it can also occur in adults. It is often associated with other conditions such as cystic fibrosis, chronic obstructive pulmonary disease (COPD), and bronchiectasis. Treatment for bronchomalacia may include medications to open the airways, physical therapy, and in severe cases, surgery.
Graft-versus-host disease (GVHD) is a condition that can occur after a bone marrow or stem cell transplant. It happens when the transplanted cells (the graft) attack the recipient's (the host) tissues and organs. This can cause a range of symptoms, including skin rash, diarrhea, liver problems, and inflammation of the lungs, gut, and blood vessels. GVHD can be a serious and potentially life-threatening complication of transplantation, but it can also be treated with medications and other therapies.
Lymphangioleiomyomatosis (LAM) is a rare lung disease that affects women, particularly those of childbearing age. It is characterized by the abnormal growth of smooth muscle cells in the walls of the lymphatic vessels and blood vessels in the lungs, leading to the formation of cysts and scarring of lung tissue. This can cause shortness of breath, chest pain, and other respiratory symptoms. LAM is also associated with the growth of tumors in the kidneys and other organs. There is no cure for LAM, but treatments such as oxygen therapy, bronchodilators, and lung transplantation can help manage symptoms and improve quality of life.
Cytomegalovirus (CMV) infections are a group of viral infections caused by the cytomegalovirus, a member of the herpesvirus family. CMV is a common virus that can infect people of all ages, but it is most commonly transmitted from mother to child during pregnancy or childbirth, or through breast milk. In healthy individuals, CMV infections are usually asymptomatic or cause mild flu-like symptoms. However, in people with weakened immune systems, such as those with HIV/AIDS, organ transplant recipients, or pregnant women with HIV, CMV infections can cause serious complications, including pneumonia, encephalitis, and retinitis. CMV infections can also be transmitted through blood transfusions, organ transplantation, and from mother to child during pregnancy or childbirth. Treatment for CMV infections typically involves antiviral medications to help control the virus and prevent complications.
Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive lung disease characterized by the scarring and thickening of the lung tissue, leading to decreased lung function and difficulty breathing. The exact cause of IPF is unknown, which is why it is referred to as "idiopathic." It typically affects people over the age of 50 and is more common in men than women. The symptoms of IPF can include shortness of breath, coughing, fatigue, and a persistent dry cough. There is currently no cure for IPF, but treatments such as oxygen therapy, pulmonary rehabilitation, and medications can help manage symptoms and slow the progression of the disease.
Cyclosporine is an immunosuppressive medication that is used to prevent the rejection of transplanted organs, such as the heart, liver, or kidney. It works by suppressing the immune system's response to the transplanted organ, allowing it to integrate into the body without being attacked by the immune system. Cyclosporine is typically administered orally in the form of capsules or tablets. It is also available as an intravenous injection for patients who cannot take it by mouth. Cyclosporine can have side effects, including increased blood pressure, kidney damage, and an increased risk of infections. It is important for patients taking cyclosporine to be closely monitored by their healthcare provider to ensure that the benefits of the medication outweigh the risks.
Carcinoma, Non-Small-Cell Lung (NSCLC) is a type of lung cancer that starts in the cells that line the airways or the alveoli (tiny air sacs) in the lungs. NSCLC is the most common type of lung cancer, accounting for about 85% of all lung cancer cases. NSCLC is further classified into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Adenocarcinoma is the most common subtype of NSCLC and is often associated with long-term exposure to tobacco smoke or other environmental factors. Squamous cell carcinoma is also associated with smoking, while large cell carcinoma is less common and can occur in both smokers and non-smokers. Treatment options for NSCLC depend on the stage of the cancer, the patient's overall health, and other factors. Treatment may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches. The goal of treatment is to remove or destroy the cancer cells and prevent them from spreading to other parts of the body.
Brain death is a medical condition in which the brain is no longer capable of performing any vital functions, including maintaining heartbeat and respiration. It is a state of irreversible coma, and it is considered to be equivalent to death in most legal and ethical contexts. The diagnosis of brain death is typically made by a team of medical professionals, including neurologists, neurosurgeons, and critical care physicians. The process involves a series of tests and evaluations, including a neurological examination, imaging studies, and tests of brain function. Once brain death has been diagnosed, the patient is considered legally and medically dead, and organ donation may be considered. However, it is important to note that brain death is not the same as clinical death, which refers to the absence of heartbeat and breathing.
In the medical field, recurrence refers to the reappearance of a disease or condition after it has been treated or has gone into remission. Recurrence can occur in various medical conditions, including cancer, infections, and autoimmune diseases. For example, in cancer, recurrence means that the cancer has come back after it has been treated with surgery, chemotherapy, radiation therapy, or other treatments. Recurrence can occur months, years, or even decades after the initial treatment. In infections, recurrence means that the infection has returned after it has been treated with antibiotics or other medications. Recurrence can occur due to incomplete treatment, antibiotic resistance, or other factors. In autoimmune diseases, recurrence means that the symptoms of the disease return after they have been controlled with medication. Recurrence can occur due to changes in the immune system or other factors. Overall, recurrence is a significant concern for patients and healthcare providers, as it can require additional treatment and can impact the patient's quality of life.
Liver failure is a medical condition in which the liver is unable to perform its normal functions effectively. The liver is a vital organ that plays a crucial role in many bodily processes, including metabolism, detoxification, and the production of bile, which helps to digest fats. There are several types of liver failure, including acute liver failure and chronic liver failure. Acute liver failure occurs suddenly and is often caused by a severe injury or infection to the liver, such as from alcohol abuse, viral hepatitis, or drug toxicity. Chronic liver failure, on the other hand, develops gradually over time and is often caused by long-term liver damage from conditions such as cirrhosis, fatty liver disease, or autoimmune hepatitis. Symptoms of liver failure can include jaundice (yellowing of the skin and eyes), abdominal pain, nausea and vomiting, fatigue, and confusion. Treatment for liver failure depends on the underlying cause and may include medications, lifestyle changes, or liver transplantation in severe cases.
Pulmonary Veno-Occlusive Disease (PVOD) is a rare and progressive lung disease characterized by the narrowing or occlusion of small blood vessels in the lungs, leading to high blood pressure in the pulmonary arteries. This can cause shortness of breath, fatigue, chest pain, and other symptoms. PVOD is often associated with other conditions such as connective tissue disorders, congenital heart defects, and exposure to certain toxins. There is currently no cure for PVOD, and treatment typically involves managing symptoms and improving quality of life.
Respiratory insufficiency is a medical condition in which the body is unable to take in enough oxygen or expel enough carbon dioxide. This can occur due to a variety of factors, including lung disease, heart disease, neurological disorders, or other medical conditions that affect the respiratory system. Symptoms of respiratory insufficiency may include shortness of breath, fatigue, confusion, dizziness, and bluish discoloration of the skin or nails. In severe cases, respiratory insufficiency can lead to respiratory failure, which is a life-threatening condition that requires immediate medical attention. Treatment for respiratory insufficiency depends on the underlying cause of the condition. In some cases, oxygen therapy may be used to increase the amount of oxygen in the blood. In other cases, medications or surgery may be necessary to treat the underlying condition causing the respiratory insufficiency. In severe cases, mechanical ventilation may be required to help the patient breathe.
In the medical field, a cadaver refers to a dead human body that has been donated for the purpose of medical education, research, or training. Cadavers are often used in anatomy classes, surgical training, and other medical education programs to help students and professionals learn about the human body and its structures. The process of donating a body for medical use is known as body donation or anatomical donation. It involves signing a consent form and making arrangements with a medical school or other organization that accepts body donations. The body is then prepared for use through a process called embalming, which involves preserving the body with chemicals to prevent decay and decomposition. Cadavers are an important resource in medical education and research, as they provide a way for students and professionals to study the human body in detail and gain hands-on experience with surgical procedures and other medical techniques.
Blood group incompatibility refers to a condition where the blood of two individuals has different blood types, resulting in an immune response when the two types are mixed. This immune response can lead to the destruction of red blood cells, which can cause symptoms such as anemia, jaundice, and organ damage. Blood group incompatibility is most commonly associated with Rh incompatibility, where a person with Rh-negative blood reacts to Rh-positive blood, but it can also occur with other blood types and antigens. In severe cases, blood group incompatibility can be life-threatening and may require medical intervention such as blood transfusions or immunosuppressive therapy.
In the medical field, an acute disease is a condition that develops suddenly and progresses rapidly over a short period of time. Acute diseases are typically characterized by severe symptoms and a high degree of morbidity and mortality. Examples of acute diseases include pneumonia, meningitis, sepsis, and heart attacks. These diseases require prompt medical attention and treatment to prevent complications and improve outcomes. In contrast, chronic diseases are long-term conditions that develop gradually over time and may persist for years or even decades.
Chronic Obstructive Pulmonary Disease (COPD) is a long-term lung disease characterized by a persistent and progressive airflow limitation that is not fully reversible. It is caused by long-term exposure to irritants such as cigarette smoke, air pollution, and chemical fumes. COPD includes two main conditions: chronic bronchitis and emphysema. Chronic bronchitis is characterized by inflammation and thickening of the lining of the bronchial tubes, which leads to increased mucus production and difficulty breathing. Emphysema, on the other hand, involves damage to the air sacs in the lungs, which makes it difficult to exhale and leads to shortness of breath. Symptoms of COPD include coughing, wheezing, shortness of breath, and chest tightness. The severity of symptoms can vary from person to person and can worsen over time. COPD is a progressive disease, and there is currently no cure. However, treatment can help manage symptoms and slow the progression of the disease.
Acute Lung Injury (ALI) is a medical condition that occurs when the lungs become inflamed and are unable to function properly. It is a serious and potentially life-threatening condition that can develop rapidly and without warning. ALI is often caused by a variety of factors, including infections, toxins, and physical trauma to the lungs. It is characterized by a decrease in the amount of oxygen that can be absorbed into the bloodstream and an increase in the amount of fluid that accumulates in the lungs. Symptoms of ALI may include shortness of breath, coughing, fever, and bluish discoloration of the skin and mucous membranes. Treatment for ALI typically involves supportive care, such as oxygen therapy, mechanical ventilation, and medications to reduce inflammation and prevent further damage to the lungs. In severe cases, ALI can progress to a more serious condition called Acute Respiratory Distress Syndrome (ARDS), which can be fatal if not treated promptly and effectively.
Lymphoproliferative disorders are a group of conditions characterized by the abnormal growth and proliferation of lymphocytes, a type of white blood cell that plays a crucial role in the immune system. These disorders can affect any part of the lymphatic system, including the lymph nodes, spleen, bone marrow, and thymus. Lymphoproliferative disorders can be classified into two main categories: Hodgkin lymphoma and non-Hodgkin lymphoma. Hodgkin lymphoma is a type of cancer that affects the lymphatic system, while non-Hodgkin lymphoma is a more general term that encompasses a wide range of lymphatic system disorders, including lymphoma, leukemia, and myeloma. Lymphoproliferative disorders can be caused by a variety of factors, including viral infections, genetic mutations, and exposure to certain chemicals or radiation. Symptoms of these disorders can vary widely depending on the specific type and location of the affected lymphatic tissue, but may include swelling of the lymph nodes, fatigue, fever, night sweats, and weight loss. Treatment for lymphoproliferative disorders typically involves a combination of chemotherapy, radiation therapy, and/or immunotherapy, depending on the specific type and stage of the disorder. In some cases, a stem cell transplant may also be necessary. The prognosis for lymphoproliferative disorders varies depending on the specific type and stage of the disorder, as well as the age and overall health of the patient.
Mycophenolic acid is an immunosuppressive drug that is used to prevent the rejection of transplanted organs, such as kidneys, liver, and heart. It works by inhibiting the production of immune cells that can attack the transplanted organ. Mycophenolic acid is often used in combination with other immunosuppressive drugs, such as corticosteroids and calcineurin inhibitors, to increase the effectiveness of the treatment and reduce the risk of rejection. It is usually administered orally in the form of a tablet or capsule. Mycophenolic acid can also be used to treat autoimmune diseases, such as rheumatoid arthritis and psoriasis, by suppressing the immune system and reducing inflammation.
Burkholderia infections are a group of bacterial infections caused by members of the Burkholderia genus. These bacteria are gram-negative, aerobic rods that are commonly found in soil and water. They can cause a variety of infections in humans, including pneumonia, meningitis, and skin infections. Some species of Burkholderia are also known to cause chronic infections in people with weakened immune systems, such as those with cystic fibrosis or HIV/AIDS. Treatment for Burkholderia infections typically involves antibiotics, although some strains of the bacteria are resistant to certain antibiotics.
Pneumonia is a respiratory infection that affects the lungs. It is caused by bacteria, viruses, or fungi, and can be acute or chronic. Symptoms of pneumonia include cough, fever, chest pain, difficulty breathing, and fatigue. Pneumonia can be treated with antibiotics, antiviral medication, or antifungal medication, depending on the cause of the infection. In severe cases, hospitalization may be necessary.
Hematologic neoplasms are a group of disorders that affect the blood and bone marrow, including the production of blood cells. These disorders are characterized by the abnormal growth and proliferation of blood cells, which can lead to an overproduction of certain types of blood cells (such as leukemias) or a deficiency of certain types of blood cells (such as anemia). Hematologic neoplasms can be either benign (non-cancerous) or malignant (cancerous), and they can affect people of all ages. Some common types of hematologic neoplasms include leukemia, lymphoma, multiple myeloma, and myelodysplastic syndromes. Treatment for hematologic neoplasms typically involves a combination of chemotherapy, radiation therapy, and/or stem cell transplantation.
Pulmonary edema is a medical condition characterized by the accumulation of excess fluid in the lungs. This can occur due to a variety of factors, including heart failure, kidney failure, severe dehydration, and certain medications. Pulmonary edema can cause shortness of breath, coughing, and difficulty breathing, and can be life-threatening if left untreated. Treatment typically involves addressing the underlying cause of the edema and providing supportive care to help the body eliminate the excess fluid.
Delayed graft function (DGF) is a condition that occurs after a kidney transplant, where the transplanted kidney does not function normally immediately after the surgery. It is characterized by a slow increase in the level of creatinine, a waste product that is normally filtered by the kidneys, in the blood. DGF can be caused by a variety of factors, including ischemia-reperfusion injury (damage to the kidney due to lack of blood flow during the transplant surgery followed by sudden restoration of blood flow), surgical complications, and rejection of the transplanted kidney by the recipient's immune system. The symptoms of DGF may include increased thirst, frequent urination, fatigue, and nausea. Treatment for DGF typically involves supportive care, such as fluid and electrolyte management, and medications to prevent rejection of the transplanted kidney. In some cases, DGF may lead to acute kidney injury or even kidney failure, which can be life-threatening. Therefore, prompt diagnosis and treatment of DGF are crucial for the success of kidney transplantation.
Lung diseases, obstructive, refer to a group of conditions that obstruct the flow of air in and out of the lungs. These conditions are characterized by a blockage or narrowing of the airways, which can make it difficult to breathe. Some common examples of obstructive lung diseases include chronic obstructive pulmonary disease (COPD), asthma, and bronchitis. These conditions can be caused by a variety of factors, including smoking, air pollution, and genetics. Treatment for obstructive lung diseases typically involves medications to open up the airways and reduce inflammation, as well as lifestyle changes such as quitting smoking and avoiding exposure to irritants. In severe cases, oxygen therapy or lung transplantation may be necessary.
In the medical field, the term "Eisenmenger Complex" refers to a rare and serious condition that affects the circulatory system. It is characterized by the presence of a congenital heart defect, specifically a hole in the heart (atrial or ventricular septal defect), that allows blood to flow abnormally from one chamber of the heart to another. Over time, this abnormal flow can cause the affected blood vessel to become enlarged and weakened, leading to a condition called pulmonary hypertension. Pulmonary hypertension is a condition in which the blood pressure in the lungs is abnormally high, which can cause the heart to work harder to pump blood through the lungs. In severe cases, Eisenmenger Complex can lead to heart failure and death. Treatment for Eisenmenger Complex typically involves medications to manage symptoms and improve quality of life, as well as surgery to repair or replace the affected blood vessel.
Viral pneumonia is a type of pneumonia caused by a viral infection. It is a common respiratory illness that can affect people of all ages, but it is most common in children and older adults. The symptoms of viral pneumonia can include fever, cough, shortness of breath, chest pain, fatigue, and body aches. Viral pneumonia is usually self-limiting, meaning that it will resolve on its own within a few days to a week without any specific treatment. However, in some cases, hospitalization may be necessary to manage severe symptoms or complications. There are many different viruses that can cause viral pneumonia, including influenza, respiratory syncytial virus (RSV), and adenovirus.
Azathioprine is a medication that is used to suppress the immune system. It is often prescribed to prevent the body from rejecting transplanted organs, such as a kidney or liver. Azathioprine is also used to treat autoimmune diseases, such as rheumatoid arthritis, lupus, and inflammatory bowel disease. It works by inhibiting the production of white blood cells, which are responsible for attacking foreign substances in the body. Azathioprine is usually taken as a pill and is often used in combination with other medications to treat these conditions.
Ganciclovir is an antiviral medication used to treat cytomegalovirus (CMV) infections. It is a nucleoside analog that works by inhibiting the replication of the virus. Ganciclovir is typically used to treat CMV retinitis, a serious eye infection that can lead to blindness, in people with AIDS or other immune system disorders. It may also be used to treat other CMV infections, such as pneumonia, colitis, and esophagitis. Ganciclovir is usually administered intravenously or intramuscularly, and the dosage and duration of treatment depend on the type and severity of the infection.
Liver diseases refer to a wide range of medical conditions that affect the liver, which is a vital organ responsible for many essential functions in the body. These diseases can be caused by various factors, including viral infections, alcohol abuse, drug toxicity, autoimmune disorders, genetic mutations, and metabolic disorders. Some common liver diseases include: 1. Hepatitis: An inflammation of the liver caused by a viral infection, such as hepatitis A, B, or C. 2. Cirrhosis: A chronic liver disease characterized by the scarring and hardening of liver tissue, which can lead to liver failure. 3. Non-alcoholic fatty liver disease (NAFLD): A condition in which excess fat accumulates in the liver, often as a result of obesity, insulin resistance, or a high-fat diet. 4. Alcoholic liver disease (ALD): A group of liver diseases caused by excessive alcohol consumption, including fatty liver, alcoholic hepatitis, and cirrhosis. 5. Primary biliary cholangitis (PBC): A chronic autoimmune liver disease that affects the bile ducts in the liver. 6. Primary sclerosing cholangitis (PSC): A chronic autoimmune liver disease that affects the bile ducts in the liver and can lead to cirrhosis. 7. Wilson's disease: A genetic disorder that causes copper to accumulate in the liver and other organs, leading to liver damage and other health problems. 8. Hemochromatosis: A genetic disorder that causes the body to absorb too much iron, leading to iron overload in the liver and other organs. Treatment for liver diseases depends on the underlying cause and severity of the condition. In some cases, lifestyle changes such as diet and exercise may be sufficient to manage the disease. In more severe cases, medications, surgery, or liver transplantation may be necessary.
The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation
Interstitial lung disease
Duke University Hospital
Andrew Logan (surgeon)
Pulmonary alveolar proteinosis
University of Mississippi
Ventricular assist device
Lung allocation score
Sharon Ann Hunt
Mandeep R. Mehra
José de Jesus Peixoto Camargo
Willis J. Potts
Pulmonary venoocclusive disease
Lung Transplantation | Lung Transplant | MedlinePlus
Lung Transplantation-Related Pathology: Definition, Epidemiology, Etiology
Lung Transplantation-Related Pathology: Definition, Epidemiology, Etiology
Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT
DCD transplantation of lungs | Lund University Publications
Heart and Lung transplantation | Lund University
Lung transplantation in telomerase mutation carriers with pulmonary fibrosis | European Respiratory Society
Ineffective esophageal motility is associated with acute rejection after lung transplantation independent of gastroesophageal...
Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation. | Thorax
Ciliary beat frequency and structure of recipient and donor epithelia following lung transplantation - ePrints Soton
ISHLT: The International Society for Heart & Lung Transplantation - Registries
ISHLT: The International Society for Heart & Lung Transplantation - Publications
Lung and Heart-Lung Transplantation - Immunology; Allergic Disorders - MSD Manual Professional Edition
Pediatric lung transplantation and end of life care in cystic fibrosis: Barriers and successful strategies<...
Lung Transplantation | NYU Langone Health
OUH - Lung transplantation and inflammation
Cardiac luxation to facilitate off-pump bilateral lung transplantation<...
Reasons for Lung Transplantation | Lung Transplant Reasons
Infectious Considerations for Lung Transplantation Archives - ATC Abstracts
Engineering Bioartificial Lungs for Transplantation
The European Society Heart and Lung Transplantation | Programme 2016
Criteria for Selecting COVID-19 Patients for Lung Transplantation - - Medtelligence
4-International-Society-of-Heart-and-Lung-Transplantation - aptiva medical s.r.l.
Transplant Medicine & Organ Transplant Services | Mount Sinai - New York
Second Wind St. Louis :: Helping Lung Transplantees to Successful Outcomes » Malignancy after Lung Transplantation
Associate Medical Director of Lung Transplantation in Manhasset, NY for quality, executive, infusion, transplant
Elective Intraoperative Use of an Avalon Elite Catheter During Lung Transplantation - Fingerprint - Northwestern Scholars
EtR for Use of an Additional COVID-19 Vaccine Dose in Immunocompromised People | CDC
XVIVO | 7. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. - XVIVO
- With greater experience and analysis of significant numbers of cases, lung transplant recipients are living longer, and follow-up regimens are becoming streamlined. (medscape.com)
- Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
- To investigate possible changes following lung transplantation, the structure and in vitro ciliary beat frequency (CBF) of airway epithelium from the cytology brushings of 9 heart-lung (HLT) and 5 single-lung (SLT) transplant recipients were examined. (soton.ac.uk)
- Donor and recipients must be size-matched anatomically (by chest x-ray), physiologically (by total lung capacity), or both. (msdmanuals.com)
- Despite the survival benefit and significant improvement in pulmonary function associated with lung transplantation, physical fitness often remains poor among recipients. (ous-research.no)
- The High Intensity Training after Lung Transplantation (HILT) study is a randomized controlled trial of a high intensity training intervention among lung transplant recipients at our centre. (ous-research.no)
- The objectives are to better understand the relationships between pulmonary function, cardiovascular fitness and physical activity among lung transplant recipients, and to determine the effects of high intensity training in this patient group. (ous-research.no)
- All solid organ transplant recipients are at risk, and lung transplant recipients are among those at highest risk. (secondwindstl.org)
- These cases generally occur in recipients who have never been infected with Epstein-Barr virus and have no immunity to the virus who receive lungs from a donor who has been infected with the virus. (secondwindstl.org)
- Background The incidence and consequences of deep venous thrombosis (DVT) and pulmonary embolism (PE) have not been described recently in lung transplant recipients. (elsevierpure.com)
- We sought to characterize DVT and PE in a contemporary series of lung transplant recipients and describe their association with clinical outcomes. (elsevierpure.com)
- Methods The records of all lung transplant recipients from July 1, 2008, to June 30, 2013, were reviewed and analyzed. (elsevierpure.com)
- Conclusions The incidence of DVT and PE in lung transplant recipients is high. (elsevierpure.com)
- Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality. (bvsalud.org)
- In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
- Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
- Effect of an Electrostimulation Program in Lung Transplant Recipients During Their Stay in the Intensive Critical Care Unit. (who.int)
- Lung transplants are used for people who are likely to die from lung disease within 1 to 2 years. (medlineplus.gov)
- Despite this, many challenges in lung transplantation remain and result in worse outcomes than other solid organ transplants. (umn.edu)
- We have collated the first experiences in the world of performing lung transplants on Covid-19 patients. (medtelligence.net)
- The Vienna team performs around 100 lung transplants a year, making it one of the largest programs in the world, alongside Toronto, Cleveland, and Hanover. (medtelligence.net)
- Mount Sinai is one of the leading health care organizations in the diagnosis and treatment of lung transplants in the country. (mountsinai.org)
- We report a case of Acetobacter indonesiensis pneumonia organism is not in any Food and Drug Administration-ap- in a 51-year-old woman after bilateral lung transplanta- proved databases and therefore would not have been identi- tion. (cdc.gov)
- we practice in Boston, where she ultimately underwent a Although this patient's isolate was resistant to the anti- bilateral lung transplant from a high-risk donor without in- microbial drugs she had received, her symptoms ultimately duction immunosuppression. (cdc.gov)
- To facilitate access to the left hilum during off-pump bilateral lung transplantation we used the Xpose 4 (TM) apical suction device (Guidant Corp., Indianapolis, IN), an off-pump coronary bypass device to luxate the heart out of the pericardium. (rug.nl)
- A roentgenogram showed bilateral lung contusion. (xvivoperfusion.com)
- Chronic GVHD (cGVHD) associated bronchiolitis obliterans syndrome (BOS) is a serious complication after allo-SCT, and lung transplantation (LTx) may be the ultimate treatment option. (nih.gov)
- A significant proportion of the lung transplant (TX) patients develop Bronchiolitis Obliterans Syndrome (BOS) (~50%), a disease marked by loss of lung function and excessive and destructive airways inflammation, frequently involving airways neutrophilia. (ous-research.no)
- Bronchiolitis obliterans syndrome after single-lung transplantation: impact of time to onset on functional pattern and survival. (bvsalud.org)
- Among risk factors for the progression of bronchiolitis obliterans syndrome (BOS) after lung transplantation (LT), the influence of time to BOS onset is not known. (bvsalud.org)
- The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
- Our department is the national referral centre for organ transplantation in Norway and is a medium-sized centre for lung transplantation by international standards. (ous-research.no)
- Low bone mass is extremely common among patients awaiting solid organ transplantation. (medscape.com)
- A large and rapid decrease in bone mineral density (BMD) occurs within the first year following virtually all forms of solid organ transplantation. (medscape.com)
- In addition to these traditional risk factors, other risk factors are associated with solid organ transplantation. (medscape.com)
- Even before transplantation, bone homeostasis may be adversely influenced by the disease process or diseased organ itself (eg, liver, lung, or kidney failure). (medscape.com)
- Long-term survival following organ transplantation has improved considerably. (medscape.com)
- Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
- Diabetes is the most common cause of kidney and pancreas transplantation. (who.int)
- Although aimed at protecting the host from infection, in the context of transplantation, this injury leads to allograft rejection. (medscape.com)
- A quick intraoperative gross examination of the lung allograft may reveal previously unrecognized lesions, the nature of which could be addressed with frozen section analysis. (medscape.com)
- Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
- Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation. (bmj.com)
- Utilizing data from the registry of lung transplantated patients and including data from the other Nordic centres in the Scandiatransplant collaboration, predictive factors for the development of allograft dysfunction and for survival are studied. (ous-research.no)
- Complications of lung transplantation include rejection of the transplanted lung and infection. (medlineplus.gov)
- Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
- After transplantation, high-dose steroid therapy and immunosuppression further promote bone loss and fracture development. (medscape.com)
- Lung or heart-lung transplantation is an option for patients who have respiratory insufficiency or failure and who remain at risk of death despite optimal medical treatment. (msdmanuals.com)
- Pediatric lung transplantation has advanced over the years, providing a potential life-prolonging therapy to patients with cystic fibrosis. (umn.edu)
- In a study published in the leading journal " The Lancet Respiratory Medicine ", the consortium has now proposed the first general selection criteria for lung transplantation in Covid-19 patients. (medtelligence.net)
- It is clear that such a complex intervention should only be considered for patients who, by virtue of their age and good general health, have a good chance of recovery with new lungs," explains Konrad Hoetzenecker, Head of the lung transplantation program at MedUni Vienna and Vienna General Hospital. (medtelligence.net)
- These guidelines can be applied worldwide for making a sound selection of patients who are suitable for a lung transplant following a Covid-19 infection. (medtelligence.net)
- The surgical team at MedUni Vienna and Vienna General Hospital has meanwhile carried out twelve lung transplantations on Covid-19 patients, demonstrating that even the most seriously ill patients, who would otherwise die, can survive with a lung transplant. (medtelligence.net)
- Our teams of specialists work with our patients to provide rehabilitation and transplantation services for people suffering from severe intestinal problems. (mountsinai.org)
- Lung transplantation can prolong and dramatically improve the quality of life for patients with advanced lung diseases. (mountsinai.org)
- Prior experience in management of lung transplant patients in an established lung transplant program is required. (nahse.org)
- The Associate Director will work with the Director on clinical duties related to management of pre- and post- lung transplant patients in both ambulatory and in-patient settings. (nahse.org)
- ISHLT is the world's largest multidisciplinary organization dedicated to improving the care of patients with advanced heart or lung disease through transplantation, mechanical circulatory support and innovative therapies. (asaecenter.org)
- Because patients often wait 2 or more years before transplantation, this represents an opportunity to prevent further bone loss and to help restore what may already have been lost. (medscape.com)
- Osteoporosis is very common among patients awaiting lung transplantation. (medscape.com)
- Shane and colleagues studied 70 patients awaiting transplant for end-stage lung disease and found osteoporosis in 30% at the lumbosacral (LS) spine and in 49% at the femur neck. (medscape.com)
- [ 7 ] Prior to transplantation, BMD was decreased at all sites measured, and 35% of patients awaiting transplant had established osteoporosis, as defined by the World Health Organization (WHO). (medscape.com)
- Aris et al reported that nearly half (45%) of patients with end-stage lung disease awaiting transplant were at or below the fracture threshold. (medscape.com)
- Moreover, following lung transplantation, nearly three quarters (73%) of patients were at or below the fracture threshold. (medscape.com)
- Donor-Derived DNA Predicts Lung Transplant Rejection Before any clinical signs of graft failure are evident in patients who undergo lung transplant, experimental research suggests that donor-derived cell-free DNA could help predict a poor outcome. (medscape.com)
- Survival Trend Seen With LVAD in Advanced Heart Failure Some patients with advanced heart failure not on the transplantation wait list might benefit from an LVAD, but robust evidence is lacking on the optimal management of patients in this 'grey zone. (medscape.com)
- Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
- Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)
- The significance of the genetic diagnosis of telomerase-mediated pulmonary fibrosis to lung transplant management has not been examined. (ersjournals.com)
- The Division of Pulmonary, Critical Care and Sleep Medicine at Northwell Health is seeking a lung transplant pulmonologist to serve as Associate Medical Director of Lung Transplantation. (nahse.org)
- The left lung was reconditioned ex vivo and kept in topical extracorporeal membrane oxygenation until it was transplanted into a 70-year-old man with chronic obstructive pulmonary disease 17 hours later. (xvivoperfusion.com)
- Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
- 7. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. (xvivoperfusion.com)
Performed a lung transplant1
- In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with Covid-19, making her the first patient in Europe to receive a lung transplant for this indication. (medtelligence.net)
- The MedUni Vienna/Vienna General Hospital thoracic surgeons and the surgical team managed to replace the patient's completely destroyed lungs with new donor lungs. (medtelligence.net)
- The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)
- Mount Sinai Transplant offers a wide range of transplantation services, including procedures related to the bone marrow , cornea , heart , intestinal , kidney , liver , and pancreas . (mountsinai.org)
- Transplantation is often used to treat end-stage kidney disease. (who.int)
- Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
- Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
- At 3 months control, a computed tomographic thoracic scan and transbronchial biopsies showed a normal left lung, and the patient was in very good clinical condition, only to succumb to death from unrelated events 11 months after the transplantation. (xvivoperfusion.com)
- The clinical focus should be to both optimize bone mass before transplantation and to prevent bone loss in the postoperative period. (medscape.com)
- Cystic fibrosis, a common indication for transplantation, is itself associated with low bone mass and fragility fractures because of (1) delayed puberty and hypogonadism and (2) chronic malnutrition with pancreatic insufficiency causing calcium and vitamin D malabsorption. (medscape.com)
- The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)
- Cor pulmonale often reverses after lung transplantation alone and is therefore rarely an indication for heart-lung transplantation. (msdmanuals.com)
- The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
- There is no cure for silicosis and only symptomatic treatment is available, including lung transplantation for the most severe cases. (cdc.gov)
- The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
- For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)
- the exception is chronic diffuse infection (eg, bronchiectasis), for which double lung transplantation is best. (msdmanuals.com)
- The cut surface shows the characteristic findings of the disease for which lung transplantation was indicated. (medscape.com)
- A Society that Includes Basic Science, the Failing Heart and Advanced Lung Disease. (ishlt.org)
- As CF lung disease progresses, children and their caregivers are often simultaneously preparing for lung transplantation and end of life. (umn.edu)
- Purpose of Review: The purposes of this study were to review current progress being made in engineering bioartificial lungs for transplantation and identify tangible benefits to the implementation of this research into development of 4D lung models for disease modeling, drug screening, and personalized medicine that could be realized in the next 5 years. (duke.edu)
- Recent Findings: We focused primarily on the generation and analysis of decellularized lung scaffolds, the repopulation of acellular lung scaffolds by primary cells and pluripotent stem cells-derived cells, and current disease modeling approaches. (duke.edu)
- After transplantation, lymphoma is often called post-transplant lymphoproliferative disease or PTLD because this represents the full spectrum of lymphoid proliferations seen after transplantation, ranging from an infectious mononucleosis-like illness to malignant non-Hodgkin's lymphoma. (secondwindstl.org)
- B-cell lymphocytic bronchiolitis and alveolar ductitis in a man with exposure to metalworking fluid s - a novel occupational lung disease. (cdc.gov)
- Introduction: Identification of a novel lung disease in workers can lead to further understanding of occupational hazards. (cdc.gov)
- Silicosis is a potentially fatal but preventable occupational lung disease caused by inhaling respirable particles containing crystalline silicon dioxide (silica). (cdc.gov)
- Those who attend the rehabilitation consultation of the hospital under study to undergo treatment prior to transplantation. (who.int)
- Over the last few decades, lung transplantation has become an accepted modality of treatment for many end-stage lung diseases. (medscape.com)
- In addition to this, candidates for a lung transplant must be in the good physical condition and have a good chance of complete physical rehabilitation following the transplant. (medtelligence.net)
- Ferrari et al also prospectively evaluated changes in bone mass in 21 consecutive lung transplant candidates and confirmed this increased osteoporosis prevalence. (medscape.com)
- BOS represents the single most important obstacle to successful long term outcome in lung transplantation.The cause of BOS is unknown, but evidence indicates that the innate host defense function may be impaired. (ous-research.no)
- The following factors were established as criteria for potential transplantation: exhaustion of all conservative treatment options, no recovery of the Covid-19-damaged lungs despite at least four weeks of ventilation/ECMO, evidence of advanced and irreversible lung damage in several consecutive CT scans, age below 65 and no relevant comorbidities. (medtelligence.net)
- Single and double lung procedures are about equally common and are at least 8 times more common than heart-lung transplantation. (msdmanuals.com)
- The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. (atcmeetingabstracts.com)
- Grafts from non-heart-beating donors, called donation-after-cardiac-death (DCD) donors, are being increasingly used because lungs from more suitable donors are lacking. (msdmanuals.com)
- Rejected donor lungs may be successfully transplanted after being reconditioned ex vivo. (xvivoperfusion.com)
- In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
- An organization of more than 3000 professionals dedicated to advancing the field of transplantation. (atcmeetingabstracts.com)
- Rarely, living adult (usually parent-to-child) lobar transplantation is done when deceased-donor organs are unavailable. (msdmanuals.com)
- In this article, we will discuss the current barriers to success in pediatric CF lung transplantation as well as approaches to end of life care in this population. (umn.edu)
- Explanted lungs should be fixed in formalin (preferably by inflating through the main bronchus) for 8-12 hours and sliced at 1-cm intervals. (medscape.com)