Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Tumors or cancer of the LUNG.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
The transference of either one or both of the lungs from one human or animal to another.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
A malignant epithelial tumor with a glandular organization.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Infection of the lung often accompanied by inflammation.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The circulation of the BLOOD through the LUNGS.
The excision of lung tissue including partial or total lung lobectomy.
Inhaling and exhaling the smoke of burning TOBACCO.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
A cell line derived from cultured tumor cells.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
An abnormal increase in the amount of oxygen in the tissues and organs.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Endoscopic examination, therapy or surgery of the bronchi.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A pathological accumulation of air in tissues or organs.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Measurement of volume of air inhaled or exhaled by the lung.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Functional competence of specific organs or body systems of the FETUS in utero.
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Established cell cultures that have the potential to propagate indefinitely.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A naturally radioactive element with atomic symbol Rn, atomic number 86, and atomic weight 222. It is a member of the noble gas family found in soil, and is released during the decay of radium.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Epithelial cells that line the PULMONARY ALVEOLI.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Refers to animals in the period of time just after birth.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Diseases caused by factors involved in one's employment.
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Any hindrance to the passage of air into and out of the lungs.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The volume of air remaining in the LUNGS at the end of a maximal expiration. Common abbreviation is RV.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Infections with bacteria of the genus PSEUDOMONAS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Relatively complete absence of oxygen in one or more tissues.
Measurement of oxygen and carbon dioxide in the blood.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
The upper part of the trunk between the NECK and the ABDOMEN. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Mechanical devices used to produce or assist pulmonary ventilation.
The measurement of an organ in volume, mass, or heaviness.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The act of BREATHING in.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An abnormality in lung development that is characterized by a multicystic mass resulting from an adenomatous overgrowth of the terminal BRONCHIOLES with a consequent reduction of PULMONARY ALVEOLI. This anomaly is classified into three types by the cyst size.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)
The act of BREATHING out.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
Antibodies produced by a single clone of cells.
Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Virus diseases caused by the ORTHOMYXOVIRIDAE.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Pleural effusion is usually present. Shallow breathing from pain can lead to lung collapse. Pancreatic enzymes may attack the ... Because pancreatitis can cause lung damage and affect normal lung function, oxygen is occasionally delivered through breathing ... pleural effusion) has been validated as similar to other prognostic scoring systems. Globally the incidence of acute ... lungs, causing inflammation. Severe inflammation can lead to intra-abdominal hypertension and abdominal compartment syndrome, ...
Figure B shows lungs with asbestos-related diseases, including pleural plaque, lung cancer, asbestosis, plaque on the diaphragm ... The presence of pleural plaques may provide supportive evidence of causation by asbestos. Although lung biopsy is usually not ... October 1982). "The pathology of asbestos-associated diseases of the lungs and pleural cavities: diagnostic criteria and ... In severe cases, the drastic reduction in lung function due to the stiffening of the lungs and reduced TLC may induce right- ...
Papiris SA, Roussos C (2004). "Pleural disease in the intensive care unit". In Bouros D (ed.). Pleural Disease (Lung Biology in ... When the pleural membranes are punctured, as occurs in penetrating trauma of the chest, air may travel from the lung to the ... Kosmas EN, Polychronopoulos VS (2004). "Pleural effusions in gastrointestinal tract diseases". In Bouros D (ed.). Pleural ... the membrane lining the lung), to the hilum of the lung, up to the trachea, to the neck and then to the chest wall. The ...
... and lung or pleural biopsies, while more technically demanding operations such as esophageal operations, mediastinal mass ... Heart Lung Circ 2007;16: 300-302 Calvin SH Ng, Innes YP Wan, Anthony PC Yim. Impact of Video-Assisted Thoracoscopic Major Lung ... Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open ... Video-Assisted Thoracic Surgery Pulmonary Resection for Lung Cancer in Patients with Poor Lung Function. Ann Thorac Surg 2006; ...
... and fusion of the layers of the pleural space surrounding the lungs resulting in decreased movement of the lung and ribcage. ... Restrictive lung disease from fibrothorax may occur when pleural fibrosis is so severe that it involves the diaphragm and ... "Pleural Thickening of Lungs: Causes, Symptoms & Treatment". Mesothelioma Center - Vital Services for Cancer Patients & Families ... These imaging techniques can detect fibrothorax and pleural thickening that surround the lungs. The presence of a thickened ...
The lungs sit in the pleural cavity. The intestines, liver, and spleen sit in the abdominal cavity. Height, weight, shape and ... ISBN 978-0-13-423435-9. "How the Lungs and Respiratory System Work", Web MD, Accessed 30 June 2019. "Lung Diseases Overview", ... there need to be as few impediments as possible to the movement of air within the lungs. Inflammation of the lungs and excess ... From here, the blood is pumped into the lungs where it receives oxygen and drains back into the left side of the heart. From ...
2000) p. 510 Miller LA (March 2006). "Chest wall, lung, and pleural space trauma". Radiologic Clinics of North America. 44 (2 ... Livingston DH, Hauser CJ (2003). "Trauma to the chest wall and lung". In Moore EE, Feliciano DV, Mattox KL (eds.). Trauma. ... Pneumothorax (an accumulation of air in the space outside the lung), clavicle fractures, and injuries to the blood vessels are ... People with scapular fractures often also have injuries of the ribs, lung, and shoulder. ...
Chest x-ray showing dense opacity pleural effusion in the lower left lung of primary pulmonary TB. 5. Hilar or mediastinal ... Blunting can be related to a small amount of fluid in the pleural space or to pleural thickening and, by itself, is a non- ... 4. Pleural effusion - Presence of a significant amount of fluid within the pleural space. This finding must be distinguished ... Pleural thickening - Irregularity or abnormal prominence of the pleural margin, including apical capping (thickening of the ...
This test shows how well the lungs are taking in oxygen. Once the presence of an excess fluid in the pleural cavity, or pleural ... Hemothorax also can occur in people with lung or pleural cancer. Hemothorax can put pressure on the lung and force it to ... It can result from acute lung injury or a lung disease like emphysema. Lung procedures, like surgery, drainage of fluid with a ... A chest X-ray takes a picture of the heart and lungs. It may show air or fluid in the pleural space. It also may show the cause ...
Intra-pleural pressure is sub-atmospheric. This is due to the recoil of the chest and lungs away from each other. Müller's ... The intrathoracic cavity is the space that includes the pleura, lungs and heart, while the pleural space is only the space ... Lungs do not collapse after forceful respiration because of residual volume. Khanorkar, p. 205 Blom, p. 7 Books Blom, J. A. ( ... When the pleural cavity is damaged/ruptured and the intrapleural pressure becomes equal to or exceeds the atmospheric pressure ...
... is highly expressed in pleural effusions (lung fluid) of patients with adenocarcinoma. Its expression was low in cancer ... "Lumican is overexpressed in lung adenocarcinoma pleural effusions". PLOS ONE. 10 (5): e0126458. Bibcode:2015PLoSO..1026458C. ...
Caplan's syndrome describes lung nodules in individuals with RA and additional exposure to coal dust. Exudative pleural ... Lung fibrosis is a recognized complication of rheumatoid arthritis. It is also a rare but well-recognized consequence of ... The disease may also affect other parts of the body, including skin, eyes, lungs, heart, nerves and blood. This may result in a ... Balbir-Gurman A, Yigla M, Nahir AM, Braun-Moscovici Y (June 2006). "Rheumatoid pleural effusion". Seminars in Arthritis and ...
... including reactive pleural disease, primary lung carcinoma, pleural metastases of other cancers, and other primary pleural ... A physical examination is performed, followed by chest X-ray and often lung function tests. The X-ray may reveal pleural ... Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space (pleural effusion) are ... pericardial and pleural cavities. Deposition of asbestos fibers in the parenchyma of the lung may result in the penetration of ...
Laterolateral chest radiographs can increase the diagnostic accuracy of lung consolidation and pleural effusion. A CT scan can ... In rare circumstances, bacteria in the lung will form a pocket of infected fluid called a lung abscess. Lung abscesses can ... Yu H (March 2011). "Management of pleural effusion, empyema, and lung abscess". Seminars in Interventional Radiology. 28 (1): ... Some viruses such as measles and herpes simplex may reach the lungs via the blood. The invasion of the lungs may lead to ...
Claims included asbestosis, lung cancer, pleural and peritoneal mesothelioma. As a condition of emerging from bankruptcy, B&W ...
Pleural effusion: Fluid in the space around the lungs. This can lead to hypoxia which can slow recovery. Pericarditis Lower ... Pneumothorax: An air collection around the lung that compresses the lung Hemothorax: Blood in the space around the lungs ... Chest tubes are placed in the mediastinal and pleural space to drain blood from around the heart and lungs. The sternum is ... The heart-lung blood circulation system and the surgery itself release a variety of debris, including bits of blood cells, ...
In the lungs, the bacteria cause abscesses, nodulary and cavitary lesions. Pleural effusion is often present. Other sites ... Pieces of the potentially infected clot can break off and travel through the right heart into the lungs as emboli, blocking ... As a consequence, the most frequently involved site of septic metastases are the lungs, followed by the joints (knee, hip, ... Memory loss Muscle pain Jaundice Decreased ability to open the jaw Crepitations are sometimes heard over the lungs Pericardial ...
Luke's Medical Center, Sugarbaker led the first multi-specialty Lung Institute in Texas, focused on the treatment of lung ... His later research focused on improving drugs for therapy of malignant pleural mesothelioma. The goal of Sugarbaker's project ... "The Henry D. Chadwick Medal". American Lung Association. American Lung Association of the Northeast. Retrieved September 28, ... "The First Comprehensive Lung Institute in Texas Offers Hope to Patients with a World Class Team of Experts". Mesothelioma.com. ...
With inhalation, the intrapleural pressure (the pressure within the pleural cavity) of the lungs decreases. Relaxing the ... Pleural pressure is the pressure in the pleural space. When this pressure is lower than the pressure of alveoli they tend to ... This phenomenon occurs because of the elastin in the elastic fibers in the connective tissue of the lungs, and because of the ... Elastic recoil means the rebound of the lungs after having been stretched by inhalation, or rather, the ease with which the ...
1]. World Health Organization Histological Classification of Lung and Pleural Tumours. 4th Edition.. ... Lung cancer was considered a very rare disease in the early part of the last century, and all malignant lung tumors were ... Lung Cancer Home Page. The National Cancer Institute site containing further reading and resources about lung cancer. [ ... Clear cell variants Giant cell carcinomas HOHMS applied to certain lung cancer variants Undifferentiated large cell lung cancer ...
Pleural carcinosis is associated with malignant pleural effusion and poor prognosis. The meningeal covering of the central ... When most tumors metastasize to the lung, they form distinct nodules, but about 7% spread through the lymph vessels of the lung ... Breast cancer, lung cancer and melanoma are the most common tumors. Colorectal cancer patients with peritoneal involvement can ... They may impair breathing in several ways; the lung becomes stiffer; blood vessels traveling alongside the distended lymph ...
This can be seen in the lungs, with the pleural cavity. Pericardial fluid is a serous fluid secreted by the serous layer of the ... Examples of effusion fluid are pleural effusion and pericardial effusion. There are many causes of effusions which include ...
Inhaling microscopic asbestos fibers can cause asbestosis, a fibrosing lung disease; pleural mesothelioma, a cancer of the ... lining (pleura) of the lung; and peritoneal mesothelioma, a cancer of the lining (peritoneum) of the abdomen. Professional ...
Complications may occur, such as exudative pleural effusion, empyema, and lung abscesses. If left untreated, aspiration ... Complications may include lung abscess. Some include chemical induced inflammation of the lungs as a subtype, which occurs from ... The two lung changes after acid aspiration are: a) direct toxic damage to the respiratory epithelium resulting in interstitial ... Aspiration pneumonia is a type of lung infection that is due to a relatively large amount of material from the stomach or mouth ...
The shadows that accompany the ribs may mimic pleural and lung disease. Scapular companion shadow overlie the scapula, with a ... Scapular companion shadows may be mistaken for a soft-tissue or pleural lesion. [1], Lange S., Walsh G. Radiology of chest ...
Anaerobic bacterial infections of the lung and pleural space.Clin Infect Dis. 1993 Suppl 4:S248-55. Brook I, Finegold SM. ... The origin of brain abscess is generally an adjacent chronic ear, mastoid, or sinus infection oropharynx, teeth or lungs. ... These infections include brain abscess, oral or dental infections, human or animal bites, aspiration pneumonia and lung ...
Flukes occasionally cause confusion when they invade the pleural space without entering the lung parenchyma. "In contrast to ... It may cause a sub-acute to chronic inflammatory disease of the lung. It is one of the most familiar lung flukes with the ... The species sometimes is called the Japanese lung fluke or oriental lung fluke. Human infections are most common in eastern ... A lung biopsy can also be used to diagnose this parasite. According to the CDC, praziquantel is the drug of choice to treat ...
Most cases of severe lung injury are due to ARDS, with or without sepsis. Pulmonary haemorrhage, pleural effusions, atelectasis ... Severe lung injury and hypoxemia result in high mortality. ...
Although pleural plaques are themselves asymptomatic, in some patients this develops into pleural thickening. Diffuse pleural ... Progressive fibrosis of the lungs of varying severity, progressing to bilateral fibrosis, honeycombing of the lungs on ... Pleural plaques: discrete fibrous or partially calcified thickened area which can be seen on X-rays of individuals exposed to ... Usually no symptoms shown but if exposure is extensive, it can cause lung impairment. Pneumothorax: Some reports have also ...
June 2018). "Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma". Lung Cancer. 120: 34-45. doi: ... interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 in lung ... proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung ... and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung ...
Pleural disease. Pleuritis/pleurisy Pneumothorax/Hemopneumothorax (Tension pneumothorax). Pleural effusion: Hemothorax · ... lung disease. Pneumoconiosis (Asbestosis, Baritosis, Bauxite fibrosis, Berylliosis, Caplan's syndrome, Chalicosis, Coalworker's ...
Lung Cancer: Usually when a lung cancer spreads to the pleural surface, the cancer has also spread to distant sites making the ... can seed the pleural surfaces in addition to invading the lung and other structures.[2][3] ... The pleura in this situation could be considered to include the surface linings of the chest wall, lungs, mediastinum, and ... Metastases to the pleural surface from any primary tumor represents Stage IV disease which carries in general an extremely poor ...
Decortication of lung. Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/pleural cavity. ... Total lung capacity (TLC)[edit]. Total lung capacity (TLC) is the maximum volume of air present in the lungs ... Static lung compliance (Cst)[edit]. When estimating static lung compliance, volume measurements by the spirometer needs to be ... Tidal volume: that volume of air moved into or out of the lungs during quiet breathing (TV indicates a subdivision of the lung ...
Gross pathology of a lung showing centrilobular emphysema characteristic of smoking. This close-up of the fixed, cut lung ... Pleural disease. *Pleuritis/pleurisy. *Pneumothorax/Hemopneumothorax. Pleural effusion. Hemothorax. Hydrothorax. Chylothorax. ... For those with very severe disease, surgery is sometimes helpful and may include lung transplantation or lung volume-reduction ... "Morbidity & Mortality: 2009 Chart Book on Cardiovascular, Lung, and Blood Diseases" (PDF). National Heart, Lung, and Blood ...
Legend: → tumor ←, ✱ central pleural effusion, 1 & 3 lungs, 2 spine, 4 ribs, 5 aorta, 6 spleen, 7 & 8 kidneys, 9 liver. ...
胸腔積液(英语:Pleural effusion). 血胸(英语:Hemothorax). 水胸(英语:Hydrothorax). 乳糜性水胸(英语:Chylothorax). 膿胸(英语:Pleural empyema). 惡性胸腔積液(英语: ... 職業性肺病(英语:Occupational lung disease). 肺塵病 石棉肺(英语:Asbestosis). 鋇塵肺(英语:Baritosis). 鐵釩土纖維化(英语:Bauxite fibrosis). 鈹肺病(英语:Berylliosis ... 養鳥人肺(英语:Bird fancier's lung). 農民肺(英语:Farmer's lung). 馬勃菌病(英语:Lycoperdonosis
It may also cause inflammation of the lungs that can result in lung scarring.[1] Chest X-rays every couple of weeks are ... It may also be put inside the chest to help prevent the recurrence of a pleural effusion due to cancer.[1] For scarring down ... Shaw, P; Agarwal, R (2004). "Pleurodesis for malignant pleural effusions". The Cochrane Database of Systematic Reviews (1): ... In our studies, mice developed classic PF with structural alteration of the lung following intravenous bleomycin treatment. ...
Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... Pleural disease. *Pleuritis/pleurisy. *Pneumothorax/Hemopneumothorax. Pleural effusion. Hemothorax. Hydrothorax. Chylothorax. ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ...
... such as pleural effusion or hemothorax can occur if the chest tubes fail to drain the fluid around the lung in the pleural ... lung. Pneumonectomy. Lobectomy. Wedge resection. Lung transplantation. Decortication of lung. Heart-lung transplant. ... pleura/pleural cavity. Thoracentesis. Pleurodesis. Thoracoscopy. Thoracotomy. Chest tube. mediastinum. Mediastinoscopy. Nuss ... A thoracotomy is a surgical procedure to gain access into the pleural space of the chest.[1] It is performed by surgeons (or ...
... pleural mesothelioma (lung) and peritoneal mesothelioma (abdomen). Fibre cement sheet is still readily available, but the ...
The pleural cavity and the pericardial cavity are exaggerated since normally there is no space between the pleurae or between ... Protects it from infections coming from other organs (such as lungs). *Prevents excessive dilation of the heart in cases of ... Here we can see its relation to the superior mediastinum a, the pleural cavities c, and the diaphragm e. ... an operation to create a hole between the pericardial and pleural spaces can be performed, known as a pericardial fenestration ...
Atin lang dakeng awsan dang "book lung" deng babagwa. Ala lang kaugnayan kareng baga (lungs) da reng vertebrate deti, pero ... Ating lang maimpis a pilatan deng adwang sapin a mitmung pleural fluid. Uli na niti, malyari lang mitagusgus king metung at ... Avian lungs[mag-edit , alilan ya ing pikuwanan]. Ing baga da reng ayup[mag-edit , alilan ya ing pikuwanan]. Komplikadu ya dapot ... Ibat ya iti king amanung Latin a pulmonarius ("of the lungs"), a kapareu na penibatan ning amanung Griyegu a pleumon ("baga"). ...
... bronchus or pleural cavity). Next, the patient's nearby lymph nodes within the chest cavity known as the mediastinum will be ... Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC ... Lung adenocarcinoma[edit]. Main article: Adenocarcinoma of the lung. Adenocarcinoma of the lung is currently the most common ... Large-cell lung carcinoma[edit]. Main article: Large-cell lung carcinoma. Large cell lung carcinoma (LCLC) is a heterogeneous ...
In the lungs, the bacteria cause abscesses, nodulary and cavitary lesions. Pleural effusion is often present.[5] Other sites ... Pieces of the potentially infected clot can break off and travel through the right heart into the lungs as emboli, blocking ... As a consequence, the most frequently involved site of septic metastases are the lungs, followed by the joints (knee, hip, ... Chest X-ray and chest CT may show pleural effusion, nodules, infiltrates, abscesses and cavitations. ...
... because the damage done to the lungs can cause the same types of changes to lung function testing that are seen in asthma. ... Extension of the lesions into the chest may lead to the development of chylous pleural and pericardial effusions. Chyle is rich ... Lymphangiomatosis patients, families, and caregivers are encouraged to join the NIH Rare Lung Diseases Consortium Contact ... lung): Pleurodesis Ligation of thoracic duct Pleurperitoneal shunt Radiation therapy Pleurectomy Surgical resection Thalidomide ...
胸腔積液(英語:Pleural effusion). 血胸(英語:Hemothorax). 水胸(英語:Hydrothorax). 乳糜性水胸(英語:Chylothorax). 膿胸(英語:Pleural empyema). 惡性胸腔積液(英語: ... 職業性肺病(英語:Occupational lung disease). 肺塵病 石棉肺. 鋇塵肺(英語:Baritosis). 鐵釩土纖維化(英語:Bauxite fibrosis). 鈹肺病(英語:Berylliosis). 類風濕塵肺綜合症(英語: ... 養鳥人肺(英語:Bird fancier's lung). 農民肺(英語:Farmer's lung). 馬勃
Thus, the hiccup is evolutionarily antecedent to modern lung respiration. Additionally, this group (C. Straus et al.) points ... as their lungs are not yet fully formed.[13] ... Pleural friction rub. *Fremitus. *Bronchophony. *Terminal ... before the motor pathways that enable normal lung ventilation form. ...
Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... Pleural disease. *Pleuritis/pleurisy. *Pneumothorax/Hemopneumothorax. Pleural effusion. Hemothorax. Hydrothorax. Chylothorax. ... Global Initiative for Chronic Obstructive Lung Disease. pp. 9-17.. *^ a b Reilly, John J.; Silverman, Edwin K.; Shapiro, Steven ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ...
October 2013). "Does external pleural suction reduce prolonged air leak after lung resection? Results from the AirINTrial after ... lung. Pneumonectomy. Lobectomy. Wedge resection. Lung transplantation. Decortication of lung. Heart-lung transplant. ... Pleural effusion: accumulation of fluid in the pleural space *Chylothorax: a collection of lymphatic fluid in the pleural space ... a pleural or system leak that should be evaluated critically. It can also indicate a leak of air from the lung. The third ...
... most often non-small-cell lung carcinoma (50 percent), small-cell lung carcinoma (25 percent), lymphoma, or metastasis, causing ... Pleural carcinomatosis is normally painless. Invasion of soft tissue by a tumor can cause pain by inflammatory or mechanical ... Dorsal root ganglion inflammation Small-cell lung cancer and, less often, cancer of the breast, colon or ovary may produce ... About 70 percent of breast and prostate cancer patients, and 40 percent of those with lung, kidney and thyroid cancers develop ...
This mechanism is meant to counteract hyperventilation, and decrease the amount of oxygen coming into the lungs. The body's " ...
Compressive asphyxia (also called chest compression) is mechanically limiting expansion of the lungs by compressing the torso, ...
In the 4th week the coelom divides into pericardial, pleural and peritoneal cavities.[2] ... At day 22, lung buds form, remaining ensheathed in a splanchnopleuric mesoderm ... which will eventually cause a partition to form the pericardial and pleural cavities. ...
Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... Pleural disease. *Pleuritis/pleurisy. *Pneumothorax/Hemopneumothorax. Pleural effusion. Hemothorax. Hydrothorax. Chylothorax. ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ...
Legend: → tumor ←, ✱ central pleural effusion, 1 & 3 lungs, 2 spine, 4 ribs, 5 aorta, 6 spleen, 7 & 8 kidneys, 9 liver. ... "Lung Cancer Screening". U.S. Preventive Services Task Force. 2004. Archived from the original on 4 November 2010.. ... "European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel". Ca. 48 (3): 167-76, discussion ... Evidence is insufficient to recommend for or against screening for skin cancer,[132] oral cancer,[133] lung cancer,[134] or ...
Spiracles are located in the pleural area. Variation of this ground plan includes the fusion of terga or terga and sterna to ... Insect respiration is accomplished without lungs. Instead, the insect respiratory system uses a system of internal tubes and ... Other theories are based on a pleural origin. These theories include suggestions that wings originated from modified gills, ... Some insects bear a sclerite in the pleural area called a laterotergite. Ventral sclerites are sometimes called laterosternites ...
Pleural effusions may occur when fluid also accumulates in the pleural cavity. ... Pulmonary edema occurs when the pressure in blood vessels in the lung is raised because of obstruction to the removal of blood ... For example, severe heart failure can cause pulmonary edema, pleural effusions, ascites and peripheral edema. Such severe ...
Measuring LDH in fluid aspirated from a pleural effusion (or pericardial effusion) can help in the distinction between exudates ... HIV and lung or liver disease.[23] ... LDH-3 (2H2M)-in the lungs. *LDH-4 (1H3M)-in the kidneys, ... Light RW, Macgregor MI, Luchsinger PC, Ball WC (October 1972). "Pleural effusions: the diagnostic separation of transudates and ... or fluid to serum albumin ratio better than the pleural fluid lactate dehydroginase in the diagnostic of separation of pleural ...
The lungs are the largest organs in the lower respiratory tract. The lungs are suspended within the pleural cavity of the ... allowing the lungs to move freely within the pleural cavity while expanding and contracting during breathing. The lungs are ... Lung cancer[edit]. Main article: Lung cancer. Some of these cancers have environmental causes such as smoking. When a tobacco ... The right lung has three lobes - upper, middle, and lower (or superior, middle and inferior), and the left lung has two - upper ...
... based on the mechanism of fluid formation and pleural fluid chemistry. Transudates result from an imbalance of oncotic and ... Pleural effusions are generally classified as transudates or exudates, ... Drugs & Diseases , Pulmonology , Pleural Effusion Q&A How are pleural effusions (fluid on the lungs) classified?. Updated: Dec ... encoded search term (How are pleural effusions (fluid on the lungs) classified?) and How are pleural effusions (fluid on the ...
... based on the mechanism of fluid formation and pleural fluid chemistry. Transudates result from an imbalance of oncotic and ... Pleural effusions are generally classified as transudates or exudates, ... Drugs & Diseases , Pulmonology , Pleural Effusion Q&A How are pleural effusions (fluid on the lungs) classified?. Updated: Dec ... Efthymiou CA, Masudi T, Thorpe JA, Papagiannopoulos K. Malignant pleural effusion in the presence of trapped lung. Five-year ...
Pleural thickening can develop when asbestos fibers cause intense scarring of the lungs. Learn about the common symptoms to ... Pleural thickening begins in the visceral pleura, the membrane covering the surface of each lung. Pleural plaques develop in ... Pleural thickening develops in the visceral pleura, the delicate membrane lining the lungs, after the lungs become inflamed. ... Treatment for Pleural Thickening. Unfortunately, it is impossible to reverse or cure this extensive lung damage. The good news ...
Pleural effusion is often referred to as "fluid in the lungs" or "water on the lungs." It is a buildup of excess pleural fluid ... Pleural effusion is common. More than 200,000 cases are diagnosed each year in the U.S. The most common cause of pleural ... Pleural effusion can become complicated if the pleural fluid becomes infected or if the extra fluid places enough pressure on ... Treating pleural effusion depends on the cause. First, treatment focuses on removing the extra fluid. Then it will treat the ...
Pleural Ultrasonography in Lung Cancer - PULC. Brief Summary Lung cancer remains the leading cause of mortality from malignant ... Pleural Ultrasonography in Lung Cancer (CT0018). The safety and scientific validity of this study is the responsibility of the ... Lung Cancer. Intervention *Procedure: thoracic ultrasound All patients will receive pre-operative pleural-based ultrasound ... Malignant pleural effusion is recognized as a poor prognosticator in non-small cell lung cancer patients and has recently been ...
... induced pleural fibrosis and lung function impairment in sheet metal workers. The evaluation group consisted of 1211 male ... An investigation was conducted of the association between asbestos (1332214) induced pleural fibrosis and lung function ... NIOSH-Grant; Lung-fibrosis; Chest-X-rays; Metal-workers; X-ray-diagnosis; Lung-function; Mathematical-models; Statistical- ... A total of 334 subjects had pleural fibrosis. Seventy eight percent of these had circumscribed plaques and 22% diffuse pleural ...
... clinicaltrials.gov Lung cancer remains the leading cause of mortality from malignant diseases in both men and women worldwide. ... Lung Cancer Lung cancer is the uncontrolled cell growth in tissues of the lung. Originating in the lungs, this growth may ... Malignant pleural effusion is recognized as a poor prognosticator in non-small cell lung cancer patients and has recently been ... More From BioPortfolio on "Pleural Ultrasonography in Lung Cancer". *Related Companies*Related Events*Related Clinical Trials* ...
... is a term which is used to refer to the buildup of extra fluid in the pleural space which is the space between the lungs and ... Almost 50% of the people with lung cancer develop a pleural effusion and the cancer that grows in the pleural space results in ... One of the ways to treat pleural effusion in lung cancer is to do tube thoracostomy which is a process that uses a tube ... It is a fact that more than 75% of patients with a malignant pleural effusion also have lymphoma or cancers of the lung, breast ...
Gazdar and associates in 1982 from the pleural fluid of a patient with large cell cancer of the lung. ... Organism: Homo sapiens, human / Tissue: lung: pleural effusion / Disease: carcinoma; large cell lung cancer ... Gazdar and associates in 1982 from the pleural fluid of a patient with large cell cancer of the lung. ... Gazdar and associates in 1982 from the pleural fluid of a patient with large cell cancer of the lung. ...
This study aimed to determine the occurrence of MMP and TIMP in lung cancer patients with malignant pleural effusions (CA). ... Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion].. [Article in German] ... MMP-1 and MMP-8 are increased in cellular rich CA pleural effusions only. The determination of MMP-9/MMP-2 ratios in pleural ... MMP-2, TIMP-1, and TIMP-2 accumulate in the pleural compartment in CA and CHF, probably reflecting an unspecific pleural ...
... have metastatic disease. The most appropriate therapy ... This patient has stage IV non-small cell lung cancer (NSCLC) as evidenced by a malignant pleural effusion. The 7th edition of ... Patients with non-small cell lung cancer and a malignant pleural effusion have, by definition, metastatic disease, and the most ... The lung fields are clear on the left, with diminished breath sounds and dullness to percussion over the lower half of the ...
Immunohistochemical and elastic fibers double staining method in assessing pleural invasion of lung cancer].. [Article in ...
PTNB should not be recommended in lung cancer patients with sub-pleural lesions. However, PTNB is recommendable to use in other ... but the risk of pleural recurrence in lung cancer patients remains undetermined. Our meta-analysis aims to answer the question ... in patients with sub-pleural lesions but not in patients without sub-pleural lesions (Odds Ratio, 0.96; 95% CI, 0.24 to 3.89). ... The results showed that PTNB does not increase risk of total recurrence (Odds Ratio,0.78; 95% CI, 0.53 to 1.15) or pleural ...
We studied the mortality from lung and pleural cancers in a cohort of 62,937 male workers employed for at least 1 year in the ... We studied the mortality from lung and pleural cancers in a cohort of 62,937 male workers employed for at least 1 year in the ... Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers.. ... The number of pleural cancer deaths among unexposed workers was 10; that among exposed workers was 14, most of which occurred ...
... the positivity and degree of staining of the well-known mesothelial marker D2-40 could be applied to differentiate pleural SM ... Aims: The differential diagnosis of pleural sarcomatoid mesothelioma (SM) from lung sarcomatoid carcinoma (LSC) invading ... The aim of this study was to identify useful antibodies that can be used for the differential diagnosis of pleural SM from LSC ... Methods and results: Forty-five cases of pleural SM and 27 cases of LSC were immunohistochemically analysed by using 15 ...
Asbestos-related pleural disease due to tremolite associated with progressive loss of lung function: Serial observations in 123 ... Of the 123 patients evaluated, the average annual age-corrected losses were 3.2% for vital capacity, 2.3% for total lung ... Montana; asbestos; asbestos mining; pulmonary function; pleural diseases. Descriptors (secondary). tremolite asbestos; USA; ... All these patients had predominantly pleural changes with minimal to no interstitial disease. The study demonstrates a ...
Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Pleural Effusion. Pleural Effusion, Malignant. Respiratory Tract Neoplasms. ... Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial Neoplasms. Pleural Diseases. Pleural Neoplasms. ... Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer (ZAP). The safety and scientific ... Malignant Pleural Effusion Non Small Cell Lung Cancer Drug: zoledronic acid Phase 2 ...
Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitroexposure to nanoscale SiO2 ... Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitroexposure to nanoscale SiO2 ... Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitroexposure to nanoscale SiO2 ...
Background:Lung cancer is the most common cause of the malignant pleural effusions(MPE).For patients with lung cancer and MPE, ... Survival of non small cell lung carcinoma patients with malignant pleural effusions. Umut Sabri Kasapoglu, Sibel Arinc, Armagan ... Survival of non small cell lung carcinoma patients with malignant pleural effusions ... Survival of non small cell lung carcinoma patients with malignant pleural effusions ...
b,I got pleural effusion in my right lung.,/b, One and a half years back, I had pneumonia. Is pleural effusion due to ... I got pleural effusion in my right lung. One and a half years back, I had pneumonia. Is pleural effusion due to tuberculosis? ... Is TB the cause of fluid around my lungs (pleural effusion)?. Answered by: Dr Sai Praveen Haranath , Senior Consultant ... Often there is lung tuberculosis along with pleural TB and you should make sure you are not infectious before traveling. This ...
Webster on lung cancer with pleural effusion: Is the lung cancer also in the lingula sometimes the cancer plugs the airway and ... Doctors help you with trusted information about Fluid In The Lungs in Lung Cancer: Dr. ... Stage iv metastatic breast cancer and malignant pleural effusion * Lung xray shows pleural thickening is that precursor to ... Lung (Definition) Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you ...
Lung Foundation Australia hosted and filmed an Asbestos-Related Lung Disease Workshop in Sydney in June 2015 which is now ... Living with a lung conditionSupport for youCOPDLung cancerRare lung diseaseOther lung conditionsPatient StoriesIndigenousUseful ... Lung Health. The lungsRecognising symptoms of lung diseaseLung testingSmoking CessationAsbestos AwarenessHealth Impacts of ... Asbestos-Related Lung Disease and Pleural Mesothelioma Training Video Now Available. Lung Foundation Australia hosted and ...
... could help doctors distinguish pleural mesothelioma from other types of lung cancer. ... Mesothelioma or Lung Cancer?. Although non-small cell lung cancer and pleural mesothelioma do share certain characteristics, ... Pleural mesothelioma is unique among cancers in that it starts on the pleural membrane that surrounds the lungs. ... Home / News / Gene Test May Help Distinguish Pleural Mesothelioma from Lung Cancer. Gene Test May Help Distinguish Pleural ...
Refined models have been developed to better predict outcomes for patients with malignant pleural mesothelioma who are ... Malignant pleural mesothelioma is a rare, but challenging disease, and the role of surgery is controversial, with a 4% ... The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of ... Founded in 1974, the associations membership includes more than 3,800 lung cancer specialists in 80 countries. To learn more ...
Palliative Surgery For Stage IV Lung Cancer - Tracheal and Pleural Disease. To view this video please enable JavaScript, and ... Adjuvant Therapy for Non-Small Cell Lung Cancer14:58. Combined Modality Therapy For Locally Advanced Non-Small Cell Lung Cancer ... Indwelling pleural catheters can result, or the placement of indwelling pleural catheters can result in a pleurodesis effect ... Molecularly Targeted Therapy for Non-Small Cell Lung Cancer28:03. FDG-PET Imaging of Non-Small Cell Lung Cancer: Treatment ...
... may be a more reliable way to diagnose malignant pleural mesothelioma than the protein fibulin-3. ... Diagnosing Pleural Mesothelioma with Lung Fluid: The Battle of the Biomarkers. Diagnosing Pleural Mesothelioma with Lung Fluid ... "Levels of FBLN3 were similar in pleural effusions from malignant pleural mesothelioma and pleural effusions from other ... The buildup of fluid around the lungs can be caused by a malignancy like pleural mesothelioma or by a non-malignant condition. ...
After pleural and liver biopsy procedures, he was conclusively diagnosed with IgG4-related lung pseudotumor and pleural ... Computed tomography showed tumors in the bilateral lower lobes of the lungs and pleural thickening. ...
Bacterial colonization of pleural drains in patients with lung cancer: an analysis of risk factors - Get your full text copy in ... Bacterial colonization of pleural drains in patients with lung cancer: an analysis of risk factors ... Conclusions: Patients with resectable lung cancer showed a high rate of pleural drain colonization, mainly by opportunistic ... Material and Method: A total of 72 pleural drain fluids obtained from 36 patients with NSCLC were microbiologically examined.. ...
Scanning electron microscopy and x-ray microanalysis of mineral deposits in lungs of a patient with pleural mesothelioma. ... Scanning electron microscopy and x-ray microanalysis of mineral deposits in lungs of a patient with pleural mesothelioma. ... Scanning electron microscopy of lung tissue, ashed at low temperature, and obtained from an insulation worker who had died of ... Despite a mean concentration of 33 x 10(6) fibres per gram of dry tissue no significant lung fibrosis was found. ...
Approximately 15% of lung cancer patients are found complicated with malignant pleural effusion (MPE) at initial diagnosis and ... Abstract #1431: Arrays analysis of lung adenocarcinoma cells in malignant pleural effusion reveals aberrant expression of ... Abstract #1431: Arrays analysis of lung adenocarcinoma cells in malignant pleural effusion reveals aberrant expression of ... Abstract #1431: Arrays analysis of lung adenocarcinoma cells in malignant pleural effusion reveals aberrant expression of ...
  • How are pleural effusions (fluid on the lungs) classified? (medscape.com)
  • Pleural effusions are generally classified as transudates or exudates, based on the mechanism of fluid formation and pleural fluid chemistry. (medscape.com)
  • Diagnosis and management of pleural effusions: a practical approach. (medscape.com)
  • The differential diagnosis of pleural effusions. (medscape.com)
  • Pleural effusions of extravascular origin. (medscape.com)
  • Diagnosis and management of malignant pleural effusions. (medscape.com)
  • Pleural effusions. (medscape.com)
  • Yinon Y, Kelly E, Ryan G. Fetal pleural effusions. (medscape.com)
  • Predicting survival in patients with recurrent symptomatic malignant pleural effusions: an assessment of the prognostic values of physiologic, morphologic, and quality of life measures of extent of disease. (medscape.com)
  • Emerging paradigms in the management of malignant pleural effusions. (medscape.com)
  • Diagnostic work-up of pleural effusions. (medscape.com)
  • Light RW, Macgregor MI, Luchsinger PC, Ball WC Jr. Pleural effusions: the diagnostic separation of transudates and exudates. (medscape.com)
  • Heffner JE, Brown LK, Barbieri CA. Diagnostic value of tests that discriminate between exudative and transudative pleural effusions. (medscape.com)
  • At this point in time, the pleural space evaluation is being performed using CT scan which does not allow the acquisition of real-time cytological material from pleural effusions due to the fact that the CT scans are done in a diagnostic setting. (clinicaltrials.gov)
  • Does the risk for development of pleural effusions (fluid on the lungs) vary by age? (medscape.com)
  • Pleural effusions usually occur in adults. (medscape.com)
  • [ 12 ] Fetal pleural effusions have also been reported and under certain circumstances may be treated prior to delivery. (medscape.com)
  • This study aimed to determine the occurrence of MMP and TIMP in lung cancer patients with malignant pleural effusions (CA). (nih.gov)
  • MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, TIMP-1, and IMP-2 oncentrations were determined by ELISA and zymography in pleural effusions and plasma of 31 CA and 14 congestive heart failure (CHF) patients and in plasma of 18 healthy controls (CON). (nih.gov)
  • MMP-1 and MMP-8 are increased in cellular rich CA pleural effusions only. (nih.gov)
  • The determination of MMP-9/MMP-2 ratios in pleural fluid may contribute to differentiate CHF from CA effusions. (nih.gov)
  • The purpose of this study is to evaluate whether the addition of the bisphosphonate Zometa (zoledronic acid) used along with standard regimens of chemotherapy, will help to control the need for palliative intervention of malignant pleural effusions due to non-small cell lung cancer. (clinicaltrials.gov)
  • Malignant pleural effusions are common in late stage non-small cell lung cancer and can lead to significantly increased morbidity in this patient population. (clinicaltrials.gov)
  • The recurrence rates are thought to be quite high overall and may approach 100% without any further treatment.Currently there is no available non-invasive, medical means for controlling the effusions other than systemic chemotherapy.Zoledronic acid has been shown in a mouse model of malignant pleural effusion to decrease fluid accumulation and tumor dissemination while prolonging survival. (clinicaltrials.gov)
  • Lung cancer is the most common cause of the malignant pleural effusions(MPE).For patients with lung cancer and MPE, the median survival is only 3-4 months.The aim of this study was evaluate the lung cancer patients with MPE clinical and laboratory findings on admission,analysis of 2 years survival and prognostic factors. (ersjournals.com)
  • And also discuss surgical options for malignant pleural effusions. (coursera.org)
  • A 2012 study published in the New England Journal of Medicine suggested that measuring the amount of FBLN3 in the plasma of people with pleural mesothelioma could help distinguish them from people with pleural effusions not due to mesothelioma. (survivingmesothelioma.com)
  • Levels of FBLN3 were similar in pleural effusions from malignant pleural mesothelioma and pleural effusions from other pathologies ," writes clinical pathology researcher Enrico Battolla. (survivingmesothelioma.com)
  • This is] in contrast to SMRP levels, which were significantly higher in pleural effusions from malignant pleural mesothelioma. (survivingmesothelioma.com)
  • The team concluded that FBLN3 was "not useful" as a diagnostic biomarker in the pleural effusions of people with malignant pleural mesothelioma since it was unable to discriminate mesothelioma from other causes of pleural effusions. (survivingmesothelioma.com)
  • Battolla, E, et al, "Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma", March 2017, Anticancer Research, pp. 1387-131. (survivingmesothelioma.com)
  • The mean value of HER-2/neu in pleural effusions of patients with ADCLC and other nonmalignant lung diseases was 9.9 and 2.7 ng/ml, respectively. (aacrjournals.org)
  • Pleural effusions in lung transplant recipients: image-guided small-bore catheter drainage. (qxmd.com)
  • Exudative pleural effusions are usually more serious and difficult to treat. (medicinenet.com)
  • There are many causes of pleural effusions. (medicinenet.com)
  • Symptoms of fever , chills , and loss of appetite often accompany pleural effusions caused by infectious agents. (medicinenet.com)
  • Pleural effusions are caused by the underlying medical problems listed previously, therefore the presence of any of these medical problems are risk factors for the development of pleural effusions. (medicinenet.com)
  • It is important to note, however, that not all individuals with these medical problems will develop pleural effusions. (medicinenet.com)
  • Congestive heart failure is the most common cause of transudative pleural effusions, while infection ( pneumonia ) and malignancy are the most common causes of exudative pleural effusions. (medicinenet.com)
  • Pleural effusions are rare. (google.com)
  • In the era of targeted therapy, the association between lung adenocarcinoma patient survival and malignant pleural effusions (MPEs) remains unclear. (cdc.gov)
  • From June 2005 to December 2010, consecutive pleural effusions were collected prospectively. (cdc.gov)
  • Methods: Using enzyme-linked immunoadsorbent assay, the concentrations of VEGF and endostatin were measured in pleural effusions (PE) and serum from a total of 70 lung cancer patients with MPE and 20 patients with tuberculosis. (koreascience.or.kr)
  • Management of malignant pleural effusions: questions that need answers. (koreascience.or.kr)
  • Transcription expression and clinical significance of vascular endothelial growth factor mRNA and endostatin mRNA in pleural effusions of patients with lung cancer. (koreascience.or.kr)
  • The priority for physicians is to distinguish non-infected reactive effusions ( "simple" parapneumonic effusions ) from pleural infection ( "complicated" parapneumonic effusions/empyema ) since this distinction is essential in determining appropriate treatment. (clinicaladvisor.com)
  • Simple parapneumonic effusions usually resolve with standard pneumonia antibiotic therapy, whereas an infected pleural space requires prompt chest tube drainage and prolonged broad-spectrum antibiotic therapy. (clinicaladvisor.com)
  • Pleural effusions found in association with pneumonia are classified as simple parapneumonic, complicated parapneumonic, and empyema. (clinicaladvisor.com)
  • Noninflammatory pleural effusions (such as transudates) are managed by treating the underlying cause and by supportive care of any functional disturbances. (medscape.com)
  • A pleural biopsy should be considered in all non-diagnostic chronic or recurrent pleural effusions. (pneumologia.eu)
  • Pleural effusions are common, with approximately 1 million cases diagnosed in the United States every year, according to the American Thoracic Society. (healthline.com)
  • In one study, 15 percent of hospitalized people diagnosed with pleural effusions died within 30 days. (healthline.com)
  • Certain types of cancer can cause pleural effusions, lung cancer in men and breast cancer in women being the most common. (healthline.com)
  • There are several types of pleural effusions, each with different causes and treatment options. (healthline.com)
  • The first classification of pleural effusions is either transudative or exudative. (healthline.com)
  • There are also complicated and uncomplicated pleural effusions. (healthline.com)
  • Uncomplicated pleural effusions contain fluid without signs of infection or inflammation. (healthline.com)
  • Complicated pleural effusions, however, contain fluid with significant infection or inflammation. (healthline.com)
  • 2011). Rapid pleurodesis for malignant pleural effusions: a pilot study. (tlc-newsletter.org)
  • The team studied 175 pleural mesothelioma patients between 2003 and 2012 who had a buildup of fluid (also known as pleural effusions) in the lungs. (prweb.com)
  • Lung cancer and breast cancer account for about 50-65% of malignant pleural effusions. (wikipedia.org)
  • Clinical factors predicting the diagnosis of malignant pleural effusions are symptoms lasting more than 1 month and the absence of fever. (wikipedia.org)
  • Ultrasound has a sensitivity of 73% and specificity of 100% at distinguishing malignant pleural effusions from other causes of pleural effusion, based on the presence of visible pleural metastases, pleural thickening greater than 1 cm, pleural nodularity, diaphragmatic thickening measuring greater than 7mm and an echogenic swirling pattern visible in the pleural fluid. (wikipedia.org)
  • Malignant pleural effusions are exudates. (wikipedia.org)
  • Identification of pleural fluid biomarkers to distinguish malignant pleural effusions from other causes of exudative effusions would help diagnosis. (wikipedia.org)
  • Biomarkers that have been shown to be raised in malignant pleural effusions compared to benign disease include vascular endothelial growth factor (VEGF), endostatin, matrix metalloproteinases and tumour markers such as carcinoembryonic antigen. (wikipedia.org)
  • The goal of treatment of malignant pleural effusions is relief of shortness of breath. (wikipedia.org)
  • Pleural fluid pH in malignant effusions. (wikipedia.org)
  • Low glucose and pH levels in malignant pleural effusions. (wikipedia.org)
  • A pleural pseudotumor is also associated with the presence of dependent pleural effusions. (wikipedia.org)
  • Accurate diagnosis, staging and therapeutic targeting of lung cancer and other pulmonary pathology are vital with regards to providing patients with expedient and accurate treatment and treatment plans. (clinicaltrials.gov)
  • The authors conclude that pleural fibrosis in asbestos exposed workers is independently associated with decrements in pulmonary function that are suggestive of an underlying restrictive defect. (cdc.gov)
  • Percutaneous transthoracic needle biopsies (PTNB) are widely used for the diagnosis of a peripheral pulmonary nodules, but the risk of pleural recurrence in lung cancer patients remains undetermined. (nature.com)
  • By the end of October 1999 pulmonary aspergillosis/empyema was diagnosed (based on lung and pleural tissue histology and culture). (aspergillus.org.uk)
  • Lung biopsies are most often done to identify pulmonary tumors or parenchymal changes (e.g. sarcoidosis). (expertsmind.com)
  • At least once during the disease course, 50% of those affected have pleural and/or pulmonary manifestations, which are associated with higher morbidity and mortality. (reumatologiaclinica.org)
  • Outcomes and pulmonary function in living lobar lung transplant donors. (qxmd.com)
  • People with lung cancer are at a higher risk of developing blood clots in the leg (called a deep vein thrombosis or DVT) and in the lung (called a pulmonary embolism). (cancer.ca)
  • Spontaneous pneumothorax may be caused by another medical condition that affects the lungs, such as chronic obstructive pulmonary disease (COPD) , but people who have no signs of lung disease can also have a spontaneous pneumothorax. (cdc.gov)
  • They are a common complication of cancers such as lung cancer and mesothelioma , as well as pulmonary conditions like pneumonia and tuberculosis . (brighamandwomens.org)
  • Pleural tuberculosis accounts for nearly 20% of Extra pulmonary tuberculosis. (springer.com)
  • Chronic obstructive pulmonary disease, or COPD, is a type of chronic lung disease that usually includes emphysema and chronic bronchitis. (medicinenet.com)
  • Treatment of tuberculous pleural effusion (TPE) is similar to that of pulmonary tuberculosis. (medscape.com)
  • A high amount of fluid can lead to fetal heart failure (hydrops) and pulmonary hypoplasia (underdeveloped lungs). (chop.edu)
  • Common conditions that could result in this type of pleural infusion include pulmonary embolisms , pneumonia , and fungal infections. (healthline.com)
  • Bringing together basic science and clinical faculty, collaboration among specialties reinforces Temple's leadership in lung transplantation, thoracic surgery, acute and chronic care of pulmonary diseases, clinical and scientific research, and medical education. (tlc-newsletter.org)
  • Pulmonary and pleural fibrosis is one of pathological characterized by Mycobacterium tuberculosis (M. tb) infection in the lungs. (elsevier.com)
  • When the lungs are infected with M. tb, the recruitment of immune cells and fibroblasts leads to granuloma formation and fibrotic scaring in interstitial lung tissue, which in turns causes irreversible loss of pulmonary function and pulmonary failure. (elsevier.com)
  • Therefore, the Central Hypothesis is that M. tb can induce CTGF expression, which in turns cause differentiation of pleural fibroblast and circulating fibrocyte to myofibroblast, and ultimately induce pleural and pulmonary fibrosis. (elsevier.com)
  • Although they do not undergo malignant transformation, patients with plaques are at risk for developing pulmonary fibrosis, lung cancer, and malignant mesothelioma. (renalandurologynews.com)
  • One of the ways scleroderma can affect the lungs is by causing pulmonary fibrosis, which is a scarring of the lungs. (sclero.org)
  • Pulmonary (Lung) Fibrosis is a scarring of the lungs, and is the consequence of untreated pulmonary inflammation (alveolitis). (sclero.org)
  • Examples of such lesions are: pleural plaques, thoracic splenosis, catamenial pneumothorax, pleural pseudotumor, diffuse pleural thickening, diffuse pulmonary lymphangiomatosis and Erdheim-Chester disease. (wikipedia.org)
  • It is a buildup of excess pleural fluid in the chest cavity and the outside of the lungs. (nationaljewish.org)
  • Symptoms of pleural effusion can include chest pain, difficulty breathing and fever. (nationaljewish.org)
  • A pleural effusion is a term which is used to refer to the buildup of extra fluid in the pleural space which is the space between the lungs and the chest wall. (onlinecancerguide.com)
  • One of the ways to treat pleural effusion in lung cancer is to do tube thoracostomy which is a process that uses a tube inserted into the chest for about 24 hours to drain out fluid. (onlinecancerguide.com)
  • A chest radiograph reveals a large right pleural effusion. (kevinmd.com)
  • The differential diagnosis of pleural sarcomatoid mesothelioma (SM) from lung sarcomatoid carcinoma (LSC) invading parietal pleura and chest wall is a challenging issue. (nih.gov)
  • Between 2008-2011, the retrospective cohort study was done in Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital and 199 cases of non small cell lung carcinoma with MPE were examined. (ersjournals.com)
  • If you get stabbed in the chest, the lung would collapse due to the destruction of the sub-atmospheric pressure in the pleural sacs in which the pressure would now be equal to that of the atmosphere. (coursehero.com)
  • A pneumothorax occurs when air or gas accumulates in the cavity between the exterior of the lung wall and the interior of the chest wall. (insiderfaq.com)
  • During normal respiration, the pleural cavity maintains an airtight seal between the chest wall and the lungs. (insiderfaq.com)
  • When air enters the pleural cavity, the lungs have no capacity to push back against the pressure building between them and the chest wall. (insiderfaq.com)
  • Treatments include the insertion of a chest tube to allow the trapped air to escape and the lungs to re-expand, as well as thoracic surgery to permanently adhere the lung to the chest wall and prevent future pneumothoraces. (insiderfaq.com)
  • Once air is allowed to enter the pleural cavity through the chest wall, the pressure will begin to restrict the expansion of the lungs and will result in a collapsed lung. (insiderfaq.com)
  • This type of pneumothorax is caused by inherent weaknesses in the lining of the lungs and can occur with or without accompanying trauma to the chest. (insiderfaq.com)
  • These imperfections in the lung linings are called blebs and they can burst, often for no discernible reason, and allow air from inside the lungs to escape into the pleural cavity between the lung and the chest wall. (insiderfaq.com)
  • When the pressure inside the pleural cavity reaches a certain point, it will begin to displace other organs inside the chest cavity. (insiderfaq.com)
  • His chest x-ray at that time showed a small unilateral pleural effusion with no other abnormalities. (advanceweb.com)
  • This helps the lungs to move smoothly in the chest when they are inflating and deflating as we breathe. (healthanddiets.com)
  • None of the guidelines recommend screening asymptomatic patients for lung cancer with chest radiograph (CXR) or sputum cytology. (medscape.com)
  • The American College of Chest Physicians (ACCP) updated its comprehensive set of lung cancer guidelines in 2013. (medscape.com)
  • Pleural effusion (or hepatic hydrothorax) is the buildup of fluid in the space between the lungs and the chest wall (called the pleural space). (cirrhosiscare.ca)
  • In many cases, the fluid build up starts in the abdomen (ascites) but eventually passes through holes in the diaphragm, into the chest (pleural effusion). (cirrhosiscare.ca)
  • Pleural effusion is usually diagnosed with a physical exam and tests like a chest X-ray or CT scan. (cirrhosiscare.ca)
  • Chest computed tomography (CT) and positron emission tomography (PET) scan showed right pleural effusion and thickness of the parietal pleura with a moderate uptake of flouro-deoxy-glucose (FDG) (Fig. 2 a, b), which was diagnosed as epithelioid MPM by thoracoscopic biopsy. (springeropen.com)
  • a Chest roentgenogram at presentation showing right pleural effusion. (springeropen.com)
  • a Chest computed tomography (CT) at presentation showing right pleural effusion and focal thickening of the parietal pleura. (springeropen.com)
  • Pleural disorders are conditions that affect the tissue that covers the outside of the lungs and lines the inside of your chest cavity. (cdc.gov)
  • Pleural effusion and pneumothorax occur when an infection, medical condition, or chest injury causes fluid, pus, blood, air, or other gases to build up in the pleural space. (cdc.gov)
  • Chest pain, shortness of breath, and coughing are common symptoms of all types of pleural disorders, but treatment for pleural disorders varies depending on what type you have and how serious it is. (cdc.gov)
  • A chest injury, even an injury that does not break the skin but causes internal damage, can allow air, fluid, or blood to leak into the pleural space. (cdc.gov)
  • Air or blood can also leak into the pleural space as a result of a medical procedure, such as a chest biopsy , mechanical ventilation , or thoracentesis . (cdc.gov)
  • chest X-rays may show the fluid or air in the pleural space or mediastinum. (templehealth.org)
  • Pleurodesis is a procedure where a mildly irritant drug is introduced into the space between the inner wall of the chest and the outer lining of the lung (pleural space). (melbourneheartsurgeon.com.au)
  • If there is already an accumulation of fluid or air in the space between your inner chest wall and outer lining of the lung, a tube is surgically placed into the chest to drain it out. (melbourneheartsurgeon.com.au)
  • Pleurodesis generally requires you to stay in the hospital for a longer period but the doctor may recommend a small flexible tube (indwelling pleural catheter) to be surgically inserted in the chest where you can go home with it and be taught how to drain or a nurse will visit you at home to drain it themselves. (melbourneheartsurgeon.com.au)
  • Normally, the body produces small amounts of fluid to lubricate the pleura-the lining around the lungs and chest cavity-and the pericardium which surrounds the heart sac. (brighamandwomens.org)
  • 26 pleural TB cases diagnosed on the basis of suggestive chest X-ray and raised serum ADA levels and healthy controls were included in the study. (springer.com)
  • A pleural effusion is a buildup of fluid in the pleural space, an area between the layers of tissue that line the lungs and the chest cavity. (medicinenet.com)
  • The development of a pleural effusion occurs from fluid seeping into the pleural space, a thin area between the visceral and pleural membranes in the chest cavity, which normally contains a small amount of fluid to facilitate smooth lung movement. (medicinenet.com)
  • For example, a patient with a history of congestive heart failure or cirrhosis with symptoms of cough, difficulty breathing, and pleuritic chest pain may have a pleural effusion. (medicinenet.com)
  • This is the thin tissue that lines the chest cavity and surrounds the lungs. (medlineplus.gov)
  • The provider will also listen to your lungs with a stethoscope and tap (percuss) your chest and upper back. (medlineplus.gov)
  • The pleural space is the area between the layers of the tissue lining the lung and the chest cavity. (medlineplus.gov)
  • ARDs were defined from chest X-rays indicating lower lung fibrosis (LFF), pleural disease (PD), and lung masses (LMs). (preprints.org)
  • To know which lung expansion techniques are chosen by chest physiotherapists who assist patients with drained and non-drained pleural effusion . (bvsalud.org)
  • Deep breathing is the most applied lung expansion technique in the treatment of patients with drained and non-drained pleural effusion by chest physiotherapists . (bvsalud.org)
  • Up to 57 percent of patients with pneumonia have an associated pleural effusion, which varies in size from a tiny sub-centimeter effusion not visible on chest X-ray to a large effusion that causes ventilatory compromise. (clinicaladvisor.com)
  • Other sources of pleural infection include esophageal rupture and intra-abdominal sources of infection (e.g., subphrenic abscess), traumatic pleural infection secondary to penetrating or blunt chest trauma, and iatrogenic pleural infection secondary to thoracic surgery or pleural procedures, such as thoracentesis or chest tube insertion. (clinicaladvisor.com)
  • [ 20 ] Other risk predictors indicating the need for chest tube placement include frank pus on thoracentesis, a positive pleural fluid Gram stain and culture finding, a pleural fluid pH level of less than 7, a glucose concentration of less than 40 mg/dL, or an LDH level of more than 1000 IU. (medscape.com)
  • Lung and pleural biopsies are essential procedures for the diagnosis of a large number of chest conditions. (pneumologia.eu)
  • Most cases affect the pleural lining, endangering the lungs, heart and chest wall, but a large fraction of cases develop in the peritoneal lining of the abdomen, potentially spreading into the organs of the gut. (asbestos.com)
  • Fetal pleural effusion is an accumulation of fluid in the chest cavity of a developing fetus. (chop.edu)
  • If fluid accumulates in the fetal chest and is severely compressing the fetal heart and lungs, we can perform a thoracentesis, a procedure performed under continuous ultrasound guidance in which we use a small needle to drain the fluid. (chop.edu)
  • need for further intervention in each group, improvement of the quality of life, respiratory improvement, radiological evaluation based on chest Xray findings, rate and duration of admissions that are related to pleural effusion during the year of study. (clinicaltrials.gov)
  • If the patient developed non expanded - trapped lung post chest tube insertion, or if he had persistence high chest tube output for more than 10 days, then the patient will remain with the PIGTAIL as an Indwelling Pleural Catheter. (clinicaltrials.gov)
  • chest tube type PIGTAIL 10 - 14 Fr will be inserted to the pleural space. (clinicaltrials.gov)
  • Pleural effusion, also called water on the lung, is an excessive buildup of fluid in the space between your lungs and chest cavity. (healthline.com)
  • Thin membranes, called pleura, cover the outside of the lungs and the inside of the chest cavity. (healthline.com)
  • There's always a small amount of liquid within this lining to help lubricate the lungs as they expand within the chest during breathing. (healthline.com)
  • This fluid accumulates in the chest cavity outside the lung, causing what's known as a pleural effusion. (healthline.com)
  • They may also order a chest X-ray to help diagnose pleural effusion. (healthline.com)
  • In a pleural fluid analysis, your doctor will remove fluid from the pleural membrane area by inserting a needle into the chest cavity and suctioning the fluid into a syringe. (healthline.com)
  • The lungs are organs of the respiratory system contained within the chest cavity. (nationalasbestos.co.uk)
  • There are two lungs, one on the left side of the chest and one on the right side. (nationalasbestos.co.uk)
  • Each lung is encased by a two-layered membrane, also known as pleura, which attach the lungs to the chest cavity. (nationalasbestos.co.uk)
  • Malignant pleural effusion is a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue (pleura) lining the outside of the lung and the wall of the chest cavity. (wikipedia.org)
  • Chest radiograph is usually performed first and may demonstrate an underlying lung cancer as well as the pleural effusion. (wikipedia.org)
  • On radiological studies, pleural plaques are visualized using conventional chest x-rays and computed tomography scans (CT scans). (wikipedia.org)
  • On radiological studies, a pleural pseudotumor is visualized as a biconcave or lenticular lesion using conventional chest x-rays and CT scans. (wikipedia.org)
  • Pleural effusion can include pleurisy, or inflammation of the pleura. (nationaljewish.org)
  • To assess how the biomarkers performed in both types of conditions, the research team included 33 patients with malignant pleural mesothelioma , 64 patients with benign tumors on their pleural membranes and 23 patients with other types of cancer that had metastasized to the pleura. (survivingmesothelioma.com)
  • However, in many cases, the cancer may exfoliate itself into the pleural cavity and may progress to a malignant pleural effusion without invading the parietal pleura. (ebscohost.com)
  • The inner-most of these membranes (the visceral pleura) is intimately connected to the lung itself. (coursehero.com)
  • Pleura is the lining that covers your lungs. (healthcaremagic.com)
  • Pleural Mesothelioma, pleura mesothelioma or malignant pleural mesothelioma is mesothelioma cancer in the lining of the lungs . (healthanddiets.com)
  • The pleura, is the tissues lining or covering that surrounds the lungs. (healthanddiets.com)
  • Background: The role of the pleura in lung cancer dissemination is of paramount importance. (eurekaselect.com)
  • Conclusion: Our study showed an impact on the prognosis of a lung cancer when tumor cells had infiltrated the elastic layer of the pleura in the PL1 and PL2 diagnostic groups. (eurekaselect.com)
  • It mainly affects the pleura, which is located in the lining of the lungs. (infobarrel.com)
  • The tissue is called the pleura, and the thin space between its two layers is called the pleural space. (cdc.gov)
  • The inset image on the left shows a closer view of the two layers of the pleura and the pleural space. (cdc.gov)
  • With pleural effusion or "water on the lungs," a build-up of excess fluid in the pleura can prevent normal breathing and cause shortness of breath . (brighamandwomens.org)
  • Pleural plaques are fibrous scar tissue on the pleura that may become calcified. (asbestos.com)
  • Pleural thickening is extensive scarring that thickens and restricts the pleura. (asbestos.com)
  • Atelectasis is a contraction of pleural scar tissue that folds the pleura into the lung. (asbestos.com)
  • Pleural mesothelioma is cancer of the pleura. (asbestos.com)
  • The body produces pleural fluid in small amounts to lubricate the surfaces of the pleura. (medlineplus.gov)
  • Moreover, tissue sampling is also essential for inflammatory conditions of the lung and the pleura, and also for microbiological diagnosis. (pneumologia.eu)
  • You can think of the lungs as the fruit or meat of an orange and the pleura or lining around the lungs as the orange peel. (summersfirm.com)
  • If the asbestos fibers do not become lodged in the airways of the lungs, the fibers may travel on to the ends of the airways, where they could continue and become blocked by the pleura, the thin lining around the lungs. (summersfirm.com)
  • Once inside the body, asbestos fibers can also migrate into the pleura, which is the tissue lining around the lungs. (asbestos.com)
  • Your doctor may also choose to perform a pleural biopsy, which involves taking a sample of tissue from the pleura. (healthline.com)
  • Malignant pleural mesothelioma (MPM) is a relatively rare but extremely aggressive cancer originating from transformation of mesothelial cells of the pleura. (nature.com)
  • Patients with malignant mesothelioma may have dullness to percussion at the base of the affected lung caused by pleural effusion and tumor invading the pleura. (renalandurologynews.com)
  • Pleural mesothelioma is a cancer of the protective lining of the lungs, which is known as the pleura. (mesothelioma.com)
  • Tumor-like disorders of the lung pleura are a group of conditions that on initial radiological studies might be confused with malignant lesions. (wikipedia.org)
  • Exposure to asbestos fibers reach the pleura of the lungs through the lymphatic channels or blood stream. (wikipedia.org)
  • The locations of the lesions are mostly in the parietal pleura of the lungs, especially in the posterior/lateral regions of the thorax, diaphragmatic domes, and lung fissures. (wikipedia.org)
  • Ectopic endometrial tissue reaches the pleural space of the lung or the right hemi-diaphragmatic region and erodes the visceral pleura, causing the formation of a spontaneous pneumothorax. (wikipedia.org)
  • Inflammatory pleuritis causes fusion of the parietal and visceral pleura of the lungs. (wikipedia.org)
  • Another diagnosis method that is used is thoracentesis which is the removal and analysis of fluid from the pleural cavity with a needle. (onlinecancerguide.com)
  • The expansion and contraction of the lungs rely on relative pressure differences between the air inside of the lungs, the fluid contained in the pleural cavity that surrounds the lungs, and the outside environment. (insiderfaq.com)
  • As the air pressure builds inside the pleural cavity, the expansion of the lung is restricted and eventually it will begin to collapse. (insiderfaq.com)
  • Pressure will continue to build inside the pleural cavity until lung expansion is restricted severely enough to cause a collapsed lung. (insiderfaq.com)
  • Because of the presence of pleural recesses, which form a kind of reserve space, the pleural cavity is larger than the lung volume. (britannica.com)
  • The plunger of the syringe was removed and the needle was slowly advanced until it reached the pleural space, where the sub-atmospheric intrapleural pressure allowed the fluid to enter the pleural cavity spontaneously. (biomedcentral.com)
  • The pressure pushes excess fluid into the pleural cavity. (cdc.gov)
  • Tuberculosis is a common cause of pleural effusion worldwide, but it is usually associated with a low mycobacterial load in the pleural cavity, and it normally develops as a type IV hypersensitivity reaction. (clinicaladvisor.com)
  • To Determine if CryoSpray Affects Production of Malignant Effusion Within the Treated Pleural Cavity. (clinicaltrials.gov)
  • To Determine if Pleural Cavity Treatment With CryoSpray is Dosimetry Dependent. (clinicaltrials.gov)
  • A Cochrane review concluded tentatively in favour of thoracoscopy to remove the fluid and blow talc into the pleural cavity (talc poudrage) compared to other commonly used methods. (wikipedia.org)
  • reported that PTNB could cause a higher pleural recurrence rate (9.1%) than bronchoscopy biopsy and sputum (1%) in patients with resected stage I non-small cell lung cancer 7 . (nature.com)
  • Randomized clinical trials (RCTs) and cohort studies, being published from 1966 to November 9, 2016, which reported comparisons of recurrence or pleural recurrence between patients diagnosed by PTNB or other invasive techniques, such as open surgery, video assisted thoracoscopic surgery or bronchoscopy biopsy etc., were included. (nature.com)
  • After pleural and liver biopsy procedures, he was conclusively diagnosed with IgG4-related lung pseudotumor and pleural inflammation with autoimmune hepatitis. (go.jp)
  • I have pleural mass in left lung 5cm I did the biopsy needle but the result was insufficient. (healthtap.com)
  • Rarely, a biopsy may be requested to assess the tissue of the pleural membrane and to rule out such things as cancer. (healthcaremagic.com)
  • As with pleural biopsy, lung biopsy may be done by surgical exposure of the lung (open lung biopsy) with or without endoscopy using a needle designed to remove a core of lung tissui. (expertsmind.com)
  • This leaflet gives you information about aftercare following your lung/pleural biopsy. (gloshospitals.nhs.uk)
  • At the same time, CT revealed a ground-glass nodule (GGN) in the left upper lobe (Fig. 2 c), which was diagnosed as lung adenocarcinoma by trans-bronchial biopsy. (springeropen.com)
  • Pleural biopsy, or lung biopsy, is recommended for the diagnosis of pleural and subpleural lung abnormalities (primary or secondary malignant tumor, tuberculosis, collagen disease, pachipleuritis, sarcoidosis etc. (pneumologia.eu)
  • There are several biopsy techniques: closed needle pleural biopsy, image-guided (thoracic ultrasound or computerized tomography) needle biopsy, and biopsy by thoracoscopy or open lung surgery. (pneumologia.eu)
  • The continuous development in the recent years of the use of thoracic ultrasound (TUS) has improved the technique and the results of the pleural and lung biopsy. (pneumologia.eu)
  • Ultrasound-guided pleural, or lung needle biopsy (USPLB), is a safe and minimal invasive real-time technique with less complications than CT-guided biopsy. (pneumologia.eu)
  • For example, no patient with suspected lung cancer should have oncological treatment in the absence of a biopsy. (pneumologia.eu)
  • The British Thoracic Society algorithm for pleural effusion (ref) indicates the need of a pleural biopsy before a thoracoscopic examination, but thora-coscopy remains the gold standard for the diagnosis of pleural pathology(2). (pneumologia.eu)
  • All specific contraindications for a pleural or lung biopsy are similar for ultrasound-guided biopsies(4 -8) (Table 2). (pneumologia.eu)
  • The proposed study is a pilot study consisting of an estimated 10 subjects with biopsy-proven metastatic cancer in the parietal pleural surface treated with CryoSpray at dye marked metastatic foci. (clinicaltrials.gov)
  • To Reduce Tumor Burden in the Pleural Space, as Determined by Visual Inspection and Biopsy of the Treatment Sites 2-5 Days Post Treatment. (clinicaltrials.gov)
  • Meanwhile, ENB is a powerful bronchoscopic technique using 'GPS'-like technology to guide tools to more distant lesions in the lung for biopsy. (rochester.edu)
  • However, in the remaining cases, pleural biopsy is required. (wikipedia.org)
  • Management of a malignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010. (medscape.com)
  • All patients being seen in the thoracic surgery pre-operative clinic with the new or presumed diagnosis of lung cancer will be approached for prospective enrolment into the study. (clinicaltrials.gov)
  • This course will provide a comprehensive, multidisciplinary introduction to state of the art approaches in the care of patients with thoracic malignancies, including various types of lung cancers and esophageal cancers. (coursera.org)
  • Board-certified thoracic surgeons and pulmonologists at the Brigham and Women's Hospital (BWH) Lung Center provide specialized medical and surgical services for pleural effusion-often using techniques that are less invasive than traditional surgery. (brighamandwomens.org)
  • The Temple Lung Center is the nation's first entirely multidisciplinary hub for thoracic medicine and surgery. (tlc-newsletter.org)
  • Thoracentesis is a procedure used to drain pleural fluid. (cirrhosiscare.ca)
  • Malignant pleural effusion can be managed with techniques including pleurodesis, repeat thoracentesis or insertion of a pleural catheter. (tlc-newsletter.org)
  • Should pleural fluid be found on the ipsilateral side to the mass (tumor), the fluid will be aspirated under sterile conditions in the clinic and sent for cytology analysis. (bioportfolio.com)
  • Intermediate filament and cross-linked envelope expression in human lung tumor cell lines. (atcc.org)
  • Compared with cytokeratin 19 fragment CYFRA 21-1, the performance of HER-2/neu as a tumor marker in pleural effusion diagnosis was better. (aacrjournals.org)
  • Overexpression of HER-2/neu in tumor tissues was found in 70% (23 of 32) of patients with MPE-associated ADCLC, 30% (13 of 43) with stage I/II non-small cell lung cancer (NSCLC), and 44% (14 of 32) with stage III NSCLC. (aacrjournals.org)
  • These findings indicate that HER-2/neu is important in the pathogenesis of MPE-associated ADCLC and is a potential tumor marker for a diagnosis of pleural effusion. (aacrjournals.org)
  • therefore, several investigators have tried to improve diagnosis by measuring tumor markers in pleural fluids. (aacrjournals.org)
  • Patients and methods: PLC was performed immediately after thoracotomy in consecutive lung cancer patients without carcinomatous pleuritis undergoing tumor resection between 1988 and 1997. (ebscohost.com)
  • A tumor may grow into an airway in the lung and block it. (medicalnewstoday.com)
  • The goal of this study was to provide a detailed evaluation of lung cancer tumor markers indicative of molecular abnormalities and to assess their diagnostic utility in non-small cell lung cancer (NSCLC) patients. (biomedcentral.com)
  • This is different from lung cancer, which refers to any type of malignant tumor that originates in the lungs. (healthanddiets.com)
  • Management of pleural mesothelioma depends largely on the staging of the tumor. (healthanddiets.com)
  • Malignant pleural mesothelioma (MPM) is an uncommon malignant tumor, and its synchronous occurrence with primary lung cancer is extremely rare. (springeropen.com)
  • Accordingly, we decided to perform a lung-sparing surgery for each tumor. (springeropen.com)
  • Here, using mice recombinant for green fluorescent protein (GFP) driven by the Wilms tumor-1 (WT-1) promoter, we demonstrate PMC trafficking into the lung and differentiation into myofibroblasts. (uab.edu)
  • Endostar combined with cisplatin inhibits tumor growth and lymphatic metastasis of lewis lung carcinoma xenografts in mice. (koreascience.or.kr)
  • Subjects will be treated with spray cryotherapy using the CryoSpray Ablation (TM) System at Day 0 using up to 3 cycles of 10-40 second sprays as the studied dosimetry and will cover the affected area, including the tumor and the parietal pleural surface. (clinicaltrials.gov)
  • When choosing a therapeutic option, we should take into account patient preference, social support, co-morbidities, presence of trapped lung or septation, prognosis, tumor biology and response to possible future therapy. (tlc-newsletter.org)
  • Sometimes doctors also insert a small tube called catheter to drain out fluid into a bottle as directed or needed as a treatment for pleural effusion. (onlinecancerguide.com)
  • A, indwelling pleural catheter. (coursera.org)
  • To evaluate the role of intrapleural positioning of a pleural catheter in early lung expansion and pleurodesis success in patients with recurrent malignant pleural effusion (RMPE). (scielo.br)
  • The patients underwent pleural catheter insertion followed by bedside pleurodesis. (scielo.br)
  • Our results suggest that the position of the tip of the pleural catheter influences neither early lung expansion nor bedside pleurodesis success in patients with RMPE. (scielo.br)
  • less than one month, The patients will be divided randomly for two groups, each group 60 patients, the first group will undergoes talc pleurodesis, the second group will undergoes Indwelling Pleural catheter insertion. (clinicaltrials.gov)
  • All patients from this group will have Indwelling Pleural Catheter insertion type PLEURAX inserted by ultrasound guided and under local anesthesia. (clinicaltrials.gov)
  • the patient and his/her family will be instructed and educated about the proper way of using the catheter, and how to perform pleural draining at home. (clinicaltrials.gov)
  • Indwelling Pleural Catheter type PLEURAX will be inserted to the pleural space. (clinicaltrials.gov)
  • malignant pleural effusion will NOT result in a pleurodesis of the space? (coursera.org)
  • We used the pleural volume on iCT scans to estimate early lung expansion and the difference between the pleural volumes on CT30 and iCT scans to evaluate radiological success of pleurodesis. (scielo.br)
  • Clinical pleurodesis success was defined as no need for any other pleural procedure. (scielo.br)
  • 20 were managed by pleural fluid drainage only whereas 14 underwent talc pleurodesis following pleural fluid drainage. (ntu.edu.sg)
  • Time taken for the pleural effusion to re-accumulate in those with and without pleurodesis was 9.9 vs. 11.7 months, p=0.59 respectively. (ntu.edu.sg)
  • Conclusion: In TKI eligible patients, early talc pleurodesis may not confer additional benefit in preventing re-accumulation of pleural effusion and may be reserved for non-adenocarcinoma histology, or EGFR negative adenocarcinoma. (ntu.edu.sg)
  • This study may allow a better understanding the mechanisms involved in the development of malignant pleural effusion and it may be promising in evaluating therapy to avoid recurrence, as the best time to indicate pleurodesis or target therapies. (biomedcentral.com)
  • The talc pleurodesis procedure involves draining lung lining of fluid and then using talc to seal the pleural layers. (prweb.com)
  • This study is significant in the fact that it could lead to more widespread acceptance of the talc pleurodesis method, which could make pleural mesothelioma patients significantly more comfortable while undergoing treatment," said Russell Budd, managing director of mesothelioma law firm Baron and Budd. (prweb.com)
  • A low pleural fluid pH is associated with poorer survival and reduced pleurodesis efficacy. (wikipedia.org)
  • This workshop aimed to inform and educate health professionals about best practice in the diagnosis, treatment and referral pathways of asbestos-related lung disease and quality care for those affected by an asbestos-related lung disease with a main focus on malignant pleural mesothelioma. (lungfoundation.com.au)
  • DENVER - Refined models have been developed to better predict outcomes for patients with malignant pleural mesothelioma who are candidates for cytoreductive surgery. (iaslc.org)
  • Malignant pleural mesothelioma is a rare, but challenging disease, and the role of surgery is controversial, with a 4% operative mortality rate. (iaslc.org)
  • The models are possible because of the development of the first large, international database that includes more than 2,000 patients with staged malignant pleural mesothelioma diagnosed from 1995-2008. (iaslc.org)
  • A biomarker called soluble mesothelin related peptide (SMRP) may be a more reliable way to diagnose malignant pleural mesothelioma from lung fluid than the protein fibulin-3. (survivingmesothelioma.com)
  • The buildup of fluid around the lungs can be caused by a malignancy like pleural mesothelioma or by a non-malignant condition. (survivingmesothelioma.com)
  • Scanning electron microscopy and x-ray microanalysis of mineral deposits in lungs of a patient with pleural mesothelioma. (bmj.com)
  • Scanning electron microscopy of lung tissue, ashed at low temperature, and obtained from an insulation worker who had died of pleural mesothelioma, showed the presence of numerous inorganic particles and fibres. (bmj.com)
  • Intravenous and oral etoposide (VP 16-213) were tested in two sequential phase II trials in chemotherapy-naive patients with malignant pleural mesothelioma. (eur.nl)
  • A grim diagnosis of malignant pleural mesothelioma (MPM) resulted. (advanceweb.com)
  • Pleural mesothelioma is the most common form of mesothelioma accounting for 80-90% of mesothelioma cases. (healthanddiets.com)
  • In addition to surgical options, radiation treatment and chemotherapy may be helpful in the overall therapeutic programfor treating pleural mesothelioma. (healthanddiets.com)
  • Pain management and home care are typical alternatives in the later stages of pleural mesothelioma. (healthanddiets.com)
  • Pleural mesothelioma is the type that occurs in almost 75% of the malignant mesothelioma cases, making it the most common kind of them all. (infobarrel.com)
  • Recombinant human endostatin (endostar) decreased recurrent ascites, pleural fluid and ascitic VEGF in a case of advanced mesothelioma. (koreascience.or.kr)
  • Lung cancer and pleural mesothelioma: What is the difference? (summersfirm.com)
  • In a post about mesothelioma last month, we explained the basics about that devastating asbestos-caused lung disease. (summersfirm.com)
  • Today we will look at the difference between the two kinds of asbestos-caused cancer in the lungs: mesothelioma and lung cancer. (summersfirm.com)
  • Lung cancer grows in the fruit or meat inside the peel and mesothelioma grows in the peel itself. (summersfirm.com)
  • Most manufacturers phased out the use of the toxic mineral when its link to terrible illnesses, such as lung cancer and mesothelioma, were publicly revealed, but asbestos still remains in millions of old buildings across the nation. (asbestos.com)
  • If you, a family member or a friend has been diagnosed with Mesothelioma, Pleural Thickening, Asbestosis, Asbestos Lung Cancer or Pleural Plaques, we are here to help. (nationalasbestos.co.uk)
  • In this chapter, the focus on two major diseases related to asbestos: pleural plaques and malignant mesothelioma. (renalandurologynews.com)
  • Diagnostic Confirmation: Are you sure your patient has Pleural plaques/Mesothelioma? (renalandurologynews.com)
  • Both forms have been associated with mesothelioma, pleural plaques, lung cancer as well as non-malignant respiratory disorders. (renalandurologynews.com)
  • Malignant pleural mesothelioma is caused by asbestos exposure in 85% of cases. (renalandurologynews.com)
  • C. History Part 3: Competing diagnoses that can mimic Pleural plaques and Mesothelioma. (renalandurologynews.com)
  • Researchers in the United Kingdom have found that a procedure that uses talc to help seal the lining of the lungs in patients suffering from pleural mesothelioma is superior to a video-assisted surgical procedure in reducing hospital stays and the occurrence of complications, the mesothelioma law firm of Baron and Budd reports. (prweb.com)
  • A method of treatment known as Video-Assisted Thoracoscopic Partial Pleurectomy (VATPP) is used in some instances in order to reduce the amount of fluid buildup that takes place between the layers of lung lining in pleural mesothelioma patients. (prweb.com)
  • Pleural mesothelioma is the most common type of the disease, accounting for 80 - 90% of all diagnoses. (mesothelioma.com)
  • What Is Pleural Mesothelioma? (mesothelioma.com)
  • Pleural mesothelioma is a type of cancer caused by asbestos fibers becoming embedded in the lining of the lungs. (mesothelioma.com)
  • Pleural malignant mesothelioma is the most common form of mesothelioma cancer. (mesothelioma.com)
  • Pleural mesothelioma is often treated with chemotherapy, surgery, radiation therapy and immunotherapy. (mesothelioma.com)
  • What Is the Prognosis for Pleural Mesothelioma? (mesothelioma.com)
  • As with all types of malignant mesothelioma, prognosis for pleural malignant mesothelioma is poor. (mesothelioma.com)
  • Most pleural mesothelioma patients are diagnosed with the epithelioid cell type , which is the most common. (mesothelioma.com)
  • Typically, pleural mesothelioma patients with the epithelioid cell type survive 19 months. (mesothelioma.com)
  • Patients with biphasic pleural mesothelioma experience an intermediate life expectancy, depending on whether epithelioid or sarcomatoid cells are more dominant. (mesothelioma.com)
  • According to recent data, within the last decade, malignant pleural mesothelioma patients have been surviving longer overall as available treatments and diagnostic methods improve. (mesothelioma.com)
  • Heather Von St. James was diagnosed with pleural mesothelioma in 2005 with an initial prognosis of 15 months. (mesothelioma.com)
  • What Are the Symptoms of Pleural Mesothelioma? (mesothelioma.com)
  • After asbestos exposure, it can take 10 to 50 years for pleural mesothelioma symptoms to present. (mesothelioma.com)
  • Other common causes include pleural mesothelioma and lymphoma. (wikipedia.org)
  • Pleural fluid mesothelin has a sensitivity of 71%, greater than that of cytology, and a specificity of 89% for the diagnosis of malignant mesothelioma. (wikipedia.org)
  • However, studies have demonstrated that pleural plaques are an independent risk factor for developing bronchogenic carcinoma and/or mesothelioma. (wikipedia.org)
  • Some of the other symptoms of pleural effusion in lung cancer include inability to exercise, inability to lie flat, pain and general feeling of being unwell. (onlinecancerguide.com)
  • Since you had symptoms and these findings are on CT scan , I think you should discuss them with a lung specialist or pulmonologist who can give you better guidance on how to proceed. (healthcaremagic.com)
  • Some of the more common lung cancer symptoms are caused by complications in the lungs. (medicalnewstoday.com)
  • It is often one of the first symptoms of lung cancer, but coughing may be a concern during all stages of the disease. (cancer.ca)
  • A very small pleural effusion may not cause any symptoms or need to be treated. (cirrhosiscare.ca)
  • In other cases where the pleural effusion is causing symptoms or there is concern about infection, treatment may be needed. (cirrhosiscare.ca)
  • Your doctor will ask you about your symptoms and medical history and will likely listen to your lungs. (templehealth.org)
  • What are the signs and symptoms of pleural effusion? (medicinenet.com)
  • Contact your provider if you have symptoms of pleural effusion. (medlineplus.gov)
  • Unlike standard bacterial pleural infection, acute presentation with TB pleuritis is uncommon, and dyspnea and constitutional symptoms develop insidiously. (clinicaladvisor.com)
  • Some people show no symptoms of pleural effusion. (healthline.com)
  • See your doctor immediately if you have symptoms of pleural effusion. (healthline.com)
  • Approximately 4% of those with localized scleroderma (such as morphea or linear or en coup de sabre) may develop respiratory symptoms, primarily restrictive pneumopathy. (sclero.org)
  • List of over a hundred medications that can cause lung disease or symptoms and also shows the associated patterns. (sclero.org)
  • Simple aspiration of pleural fluid can relieve shortness of breath rapidly but fluid and symptoms will usually recur within a couple of weeks. (wikipedia.org)
  • Infection, irritation or inflammation can create excess fluid and cause pleural effusion. (nationaljewish.org)
  • Pneumonia by itself can cause fluid collection and TB is one of the causes but other infections also cause pleural effusion. (ndtv.com)
  • Asbestos-induced pleural fibrosis and impaired lung function. (cdc.gov)
  • An investigation was conducted of the association between asbestos (1332214) induced pleural fibrosis and lung function impairment in sheet metal workers. (cdc.gov)
  • Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers. (cdc.gov)
  • Lung Foundation Australia hosted and filmed an Asbestos-Related Lung Disease Workshop in Sydney in June 2015 which is now available online. (lungfoundation.com.au)
  • Asbestos can wreak havoc on human lungs. (summersfirm.com)
  • Asbestos can cause disease and injury in the lungs when its microscopic fibers are inhaled. (summersfirm.com)
  • A comparison to the orange is helpful to understand the asbestos-related cancers that can impact the lungs . (summersfirm.com)
  • The tiny specks of asbestos when breathed in along with air pass through the airways of the lungs and may become lodged in the walls of the airways, potentially causing lung cancer. (summersfirm.com)
  • Lung cancer from asbestos exposure usually develops in the cells that line the airways, according to the National Institutes of Health or NIH. (summersfirm.com)
  • It cannot be overemphasized that anyone who smokes and has been exposed to asbestos, even years ago, should make every effort to stop smoking, as the risk of developing lung cancer from asbestos exposure rises sharply in people who also smoke tobacco. (summersfirm.com)
  • Amazingly, the National Cancer Institute at NIH says that a smoker with past asbestos exposure has a greater risk of lung cancer than "the individual risks from asbestos and smoking added together. (summersfirm.com)
  • When asbestos collects in the soft tissue of the lungs, scar tissue may build as the immune system tries to expel the fibers. (asbestos.com)
  • Lung cancer is usually caused by smoking tobacco products, but each year, many thousands of cases also trace back to asbestos exposure. (asbestos.com)
  • Asbestos-related lung cancer kills more Americans than any other asbestos-related illness. (asbestos.com)
  • Irritation from lodged asbestos fibers may lead to development of hard plaques or scarring in the two layers of the pleural lining, which can make breathing painful. (asbestos.com)
  • Pleural plaques are the most common pleural changes caused by asbestos. (renalandurologynews.com)
  • Asbestos is a known carcinogen and the risk of developing lung cancer can be multiplicative with use of cigarette smoking. (renalandurologynews.com)
  • The 7th edition of the TNM staging system has reclassified malignant pleural effusion as a distant metastasis, automatically placing such patients into stage IV disease status. (kevinmd.com)
  • Surgery would not be recommended in this patient because the presence of a malignant pleural effusion confirms that this patient's disease is not curable. (kevinmd.com)
  • Patients with non-small cell lung cancer and a malignant pleural effusion have, by definition, metastatic disease, and the most appropriate therapy is palliative systemic chemotherapy. (kevinmd.com)
  • also reported that PTNB might increase the risk of pleural implantation in stage I lung cancer patients, especially patients with stage IB disease 8 . (nature.com)
  • All these patients had predominantly pleural changes with minimal to no interstitial disease. (ilo.org)
  • specifically talking about tracheal and pleural disease. (coursera.org)
  • AngeboteThe people are the service-oriented spans at the lung biology in health disease volume 186 pleural of foundation nutrition business and source, then seek Dirty assumptions that start the community to important events in period people down such under the mandatory rat scene. (kung-fu-berlin.de)
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  • Approximately 15 % of lung cancer patients present pleural effusion at the time of diagnosis and half of them develop pleural effusion at disease advanced stages [ 1 - 5 ]. (biomedcentral.com)
  • Quantitative real-time RT-PCR was used to determine LunX, CK19, CEA, VEGF-C and hnRNP A2/B1 mRNA levels in peripheral blood and pleural fluid from NSCLC patients, compared with those from patients with other epithelial cancer (esophagus cancer and breast cancer), benign lung disease (pneumonia and tuberculo pleurisy) and from healthy volunteers. (biomedcentral.com)
  • In peripheral blood LunX mRNA was detectable in 75.0% (33/44) of patients with NSCLC, but not in patients with other epithelial cancer (0/28), benign lung disease (0/10) or in healthy volunteers (0/15). (biomedcentral.com)
  • In contrast, all other genetic markers were detected in patients with either NSCLC, other epithelia cancer or benign lung disease, and in healthy volunteers. (biomedcentral.com)
  • Eating properly can help your body fight disease and cope with the effects of lung cancer treatment. (cancer.ca)
  • The origin of the myofibroblast in fibrotic lung disease is uncertain, and no effective medical therapy for fibrosis exists. (uab.edu)
  • Buonsenso D, Piano A, Raffaelli F, Bonadia N, de Gaetano Donati K, Franceschi F. Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak. (google.com)
  • Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak. (google.com)
  • Patients in stage IV lung adenocarcinoma with MPEs at initial diagnosis have shorter overall survival and higher EGFR mutation rate, especially for L858R, than patients who develop MPEs following disease progression. (cdc.gov)
  • Malignant pleural disease at baseline was significantly associated with subsequent peritoneal spread. (elsevier.com)
  • Conclusions: Malignant pleural disease is highly associated with peritoneal metastasis in patients with advanced NSCLC. (elsevier.com)
  • Additional studies exploring treatment related factors in patients with malignant pleural disease that can reduce risk of peritoneal metastasis are warranted. (elsevier.com)
  • So it would stand to reason that for tobacco smokers, low-dose CT lung cancer screening (LDCT LCS) would be a worthwhile intervention, given their higher level of risk for the disease. (medpagetoday.com)
  • Clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP). Compared with cryptogenic organizing pneumonia patients, AIRD-OP patients are characterized with occult onset but more severe lung involvement and higher recurrence rate. (sclero.org)
  • Scleroderma-related Interstitial Lung Disease (SSc-ILD) Not Linked to Idiopathic Interstitial Pneumonia. (sclero.org)
  • The cells express easily detectable p53 mRNA at levels comparable to normal lung tissue, and exhibit no gross structural DNA abnormalities. (atcc.org)
  • Despite a mean concentration of 33 x 10(6) fibres per gram of dry tissue no significant lung fibrosis was found. (bmj.com)
  • C57BL/6 mice received intrapleural injection of 0.1, 0.5 or 1.5 × 10 5 LLC cells and survival curve, biochemical and pathological analyses of pleural fluid and tissue were analyzed. (biomedcentral.com)
  • To maintain the quality of the study, only patients with malignant cells in the pleural fluid or tissue were included. (biomedcentral.com)
  • The buildup of scar tissue gradually stiffens the lungs, making it harder to breathe as the asbestosis progresses. (asbestos.com)
  • The expression of connective tissue growth factor (CTGF), a fibrotic factor, has been reported in lung fibrosis. (elsevier.com)
  • Following thoracoabdominal trauma, most commonly a penetrating injury, laceration of the diaphragm, and spleen allows ectopic splenic tissue to reach the pleural space of the lung. (wikipedia.org)
  • When fluid builds up in the pleural space, the lungs may not be able to expand completely. (cirrhosiscare.ca)
  • Pneumothorax occurs when air or other gas builds up in the pleural space and may cause part or all of the lung to collapse. (cdc.gov)
  • A total of 334 subjects had pleural fibrosis. (cdc.gov)
  • The subjects with fibrosis tended to be older, retired, to have more experience in the sheet metal trade, and to have more pack years smoking than those with normal lungs. (cdc.gov)
  • Both forms of pleural fibrosis were associated with significant decreases in 1 second forced expiratory volume (FEV1) and forced vital capacity (FVC). (cdc.gov)
  • WT-1-expressing cells were present within fibrotic regions of the lungs in IPF subjects, supporting a role for PMC differentiation and trafficking as contributors to the myofibroblast population in lung fibrosis. (uab.edu)
  • Our findings also support a potential role for pleural-based therapies to modulate pleural mesothelial activation and parenchymal fibrosis progression. (uab.edu)
  • Vascular endothelial growth factor in pleural fluid for differential diagnosis of benign and malignant origin and its clinical applications. (koreascience.or.kr)
  • No treatment is required since pleural plaques are benign. (wikipedia.org)
  • Abstract: Purpose: The clinical significance of intraoperative pleural lavage cytology (PLC) for lung cancer has been insufficiently elucidated. (ebscohost.com)
  • Abstract: Objective: Positron emission tomography has proven to be an invaluable tool for diagnosing and staging non-small cell lung cancer. (ebscohost.com)
  • Lung cancer remains the leading cause of mortality from malignant diseases in both men and women worldwide. (clinicaltrials.gov)
  • BACKGROUND: Lung cancer is one of the most common malignant diseases in the world that has turned to into a big problem for world health organizations in the diagnosis and cure field. (minervamedica.it)
  • The incidence of malignant lung diseases is increased in systemic lupus erythematosus. (reumatologiaclinica.org)
  • Two lesions were judged to be synchronous MPM and lung cancer that were both potentially resectable clinical stage I diseases, and complete resection of both tumors was successfully achieved with right P/D following left upper division segmentectomy. (springeropen.com)
  • Whole-body CT, PET scan, and brain magnetic resonance imaging revealed no nodal or distant metastasis, and the two lesions were judged to be synchronous MPM and lung cancer that were both potentially resectable clinical stage I diseases. (springeropen.com)
  • Search our A to Z guide to locate general information about lung diseases, conditions, treatments, and clinical programs at Brigham and Women's Hospital. (brighamandwomens.org)
  • The spectrum of pleural diseases associated with exposure can range from pleural plaques to effusion and malignancy. (renalandurologynews.com)
  • Use of pleural fluid N-terminal-pro-brain natriuretic peptide and brain natriuretic peptide in diagnosing pleural effusion due to congestive heart failure. (medscape.com)
  • More than 200,000 cases are diagnosed each year in the U.S. The most common cause of pleural effusion is congestive heart failure . (nationaljewish.org)
  • Computed tomography showed tumors in the bilateral lower lobes of the lungs and pleural thickening. (go.jp)
  • Patients with tumors without evidence of pleural invasion, with positive surgical margins or with other histologic subtype than adenocarcinoma were excluded. (eurekaselect.com)
  • Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion]. (nih.gov)
  • Angiogenetic biomarkers in non-small cell lung cancer with malignant pleural effusion: correlations with patient survival and pleural effusion control. (koreascience.or.kr)
  • Chemically - This involves putting chemicals such as bleomycin, tetracycline, povidone iodine or slurry of talc into the pleural space. (melbourneheartsurgeon.com.au)
  • Chemicals such as talc may be placed in the space around the lung to 'scar' it into position. (rochester.edu)
  • Many people with lung cancer have problems with breathing and shortness of breath. (cancer.ca)
  • This study will consist of a prospective evaluation of surgeon-performed pleural and diaphragmatic ultrasound in the pre-operative evaluation of lung cancer patients. (clinicaltrials.gov)
  • Lung ultrasound (LUS) is an alternative to time-consuming CT scans , improving throughput and transmission risk. (google.com)
  • Lung ultrasound is relatively easy to learn. (google.com)
  • This review aims to summarize the key technical elements of ultrasound-guided pleural and lung biopsies, in order to promote the development of these techniques in Romania. (pneumologia.eu)
  • A diagnosis of pleural effusion is usually made by ultrasound. (chop.edu)
  • Pneumonia is a possible symptom of complications in the lungs caused by cancer. (medicalnewstoday.com)
  • Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? (google.com)
  • In a person with parapneumonic pleural effusion, the fluid buildup is caused by pneumonia . (medlineplus.gov)
  • Pneumonia, most commonly from bacteria, causes parapneumonic pleural effusion. (medlineplus.gov)
  • Pleural space infection/empyema is usually seen in association with pneumonia, although primary empyema is occasionally seen (~4%) with no radiographic evidence of pneumonia or other obvious cause. (clinicaladvisor.com)
  • Pleural infection should be suspected in any patient who presents with pneumonia and is found to have a pleural effusion. (clinicaladvisor.com)
  • Pleural infection should also be suspected in those with a non-resolving pneumonia despite appropriate antibiotic therapy (i.e., ongoing fevers, poorly resolving C-reactive protein, or high white cell count). (clinicaladvisor.com)
  • A study by Tagarro et al that included 60 randomized children with community-acquired pneumonia and pleural effusion reported that patients receiving dexamethasone along with antibiotics had a shorter time to recovery than the placebo group. (medscape.com)
  • Aspiration pneumonia occurs when vomitus or reflux gets into the lungs, causing an often deadly form of pneumonia. (sclero.org)
  • Solitary organizing pneumonia (SOP) in systemic sclerosis (SSc) mimicking lung adenocarcinoma. (sclero.org)
  • Transudative pleural effusion is caused by pressure in the blood vessels, most often because of a medical condition such as heart, kidney, or liver failure. (cdc.gov)
  • Transudative pleural effusion is caused by fluid leaking into the pleural space. (medlineplus.gov)
  • however, malignant cells in the pleural fluid were negative for thyroglobulin. (springermedizin.de)
  • The aim of this study was to identify useful antibodies that can be used for the differential diagnosis of pleural SM from LSC. (nih.gov)
  • We therefore conducted this meta-analysis to assess whether PTNB strategy will increase the risk of pleural recurrence. (nature.com)
  • Positive pre-resection pleural lavage cytology is associated with increased risk of lung cancer recurrence in patients undergoing surgical resection: a meta-analysis of 4450 patients. (ebscohost.com)
  • No systematic review has investigated the relationship between PLC and lung cancer recurrence. (ebscohost.com)
  • This is done to prevent the recurrence of a lung collapse (pneumothorax) or accumulation of air or fluid in the space (pleural effusion). (melbourneheartsurgeon.com.au)
  • Response to initial drainage will give us insight into how much the effusion contributes to the symptom of breathlessness, whether the lung is trapped, and the speed of recurrence. (tlc-newsletter.org)
  • High level of serum CRP,lower serum albumin,lower pleural protein,MPE with distant metastasis were determined to be the most important prognostic factors for non small cell lung carcinoma patients with MPE. (ersjournals.com)
  • This study evaluated our cases of sleeve resection for squamous cell carcinoma of the lung and compared the outcomes with the literature reports. (ebscohost.com)
  • To the best of our knowledge, this is the first report of an autopsy case of anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion. (springermedizin.de)
  • We report an autopsy case of a 61-year-old Japanese man with anaplastic transformation of papillary thyroid carcinoma with multiple lung metastases presenting with a malignant pleural effusion, which was difficult to diagnose by cytological examination before the autopsy. (springermedizin.de)
  • It is important to be aware that anaplastic transformation of differentiated thyroid carcinoma could develop in lung metastases and could be a cause of a malignant pleural effusion. (springermedizin.de)
  • Al-Qsous W, Miller ID: Anaplastic transformation in lung metastases of differentiated papillary thyroid carcinoma: an autopsy case report and review of the literature. (springermedizin.de)
  • The objective of this study is to evaluate the role of different concentrations of Lewis lung carcinoma cells (LLC cells) at the time of induction of experimental MPE and the main effects on survival of animals. (biomedcentral.com)
  • The Lewis lung carcinoma (LLC) cells were purchased from the American Type Culture Collection (Manassas, VA, USA) and were cultured at 37 °C in 5 % CO 2 − 95 % air using Dulbecco's modiWed Eagle's medium (DMEM) with 10 % fetal bovine serum. (biomedcentral.com)
  • SOP is often misdiagnosed and removed surgically as it is rare and difficult to distinguish from lung carcinoma. (sclero.org)
  • There are three types of pleural disorders-pleurisy, pleural effusion, and pneumothorax-and they have varying causes. (cdc.gov)
  • The types of pleural disorders are pleural effusion, pleurisy, and pneumothorax. (cdc.gov)
  • Introduction: Peritoneal metastasis from lung cancer is an uncommon clinical event and there are limited data on what factors predict peritoneal progression. (elsevier.com)
  • This study retrospectively investigated whether patterns of metastatic spread and oncogene status in patients with advanced non-small cell lung cancer (NSCLC) are associated with peritoneal metastasis. (elsevier.com)
  • Conclusion Detection of CEA, CA125, CA153 and CA199 in pleural fluid might be helpful for diagnosing lung cancer, and the optimal combination for assay is CEA+CA199. (cnki.com.cn)
  • Is pleural effusion due to tuberculosis? (ndtv.com)
  • Often there is lung tuberculosis along with pleural TB and you should make sure you are not infectious before traveling. (ndtv.com)
  • and oxidative stress markers [protein carbonyl and malondialdehyde (MDA)] in pleural tuberculosis. (springer.com)
  • Results: Compared to patients with tuberculosis, the levels of VEGF and endostatin in both PE and serum were significantly higher in patients with lung cancer. (koreascience.or.kr)
  • Several studies indicated that the fibrotic factors, such as transforming growth factor- (TGF-), were increased in pleural effusion and serum of patient with tuberculosis. (elsevier.com)
  • However, the role of CTGF in the differentiation of pleural fibroblast and circulating fibrocyte to myofibroblast in patient with tuberculosis is still unknown. (elsevier.com)
  • In conclusion, PTNB should not be recommended in lung cancer patients with sub-pleural lesions. (nature.com)
  • However, PTNB is recommendable to use in other patients without sub-pleural lesions to whom pathological diagnosis is necessary, especially in patients with relevant comorbidities. (nature.com)
  • Lung lesions, however, can be difficult to target. (pneumologia.eu)
  • Radiology-guided procedures to help targeting lung lesions have been used in pneumological practice for a long time. (pneumologia.eu)
  • The purpose of this study is to evaluate the safety, efficacy, and side effects of the CryoSpray Ablation(TM) System (CSA(TM) System) to treat neoplastic lesions on the parietal pleural surface. (clinicaltrials.gov)
  • The locations of the lesions are mostly in the lower left pleural space and/or splenic bed. (wikipedia.org)
  • The location of the lesions is mostly in the upper lobes of the lungs, usually in a lymphatic distribution. (wikipedia.org)
  • Microbial colonization of pleural drains during the postoperative period may be regarded as an important factor in infection development. (medscimonit.com)
  • Patients with resectable lung cancer showed a high rate of pleural drain colonization, mainly by opportunistic pathogens, even in the absence of clinical signs of infection. (medscimonit.com)
  • Bacterial infection is most frequently the cause of lung involvement in lupus and is one of the most important causes of death. (reumatologiaclinica.org)
  • Diagnosis and outcome of early pleural space infection following lung transplantation. (qxmd.com)
  • Exudate is typically produced by inflammatory conditions (lung infection, malignancy ). (medicinenet.com)
  • The gold standard for diagnosis of pleural space infection is a microbiological culture of pathogens in pleural fluid. (clinicaladvisor.com)
  • Bacterial and host cell metabolism in the pleural space causes a characteristic biochemical pattern with low pH, low glucose, and high LDH, and these criteria are used to define infection when the culture is negative. (clinicaladvisor.com)
  • Pleural infection may also be defined as community-acquired or healthcare-associated infection. (clinicaladvisor.com)
  • Gram-positive aerobic bacteria are the commonest cause of pleural infection. (clinicaladvisor.com)
  • The underlying cause of pleural effusion in a fetus may include genetic issues, infection, and heart or lung conditions. (chop.edu)
  • Malignant pleural effusion (MPE) resulting from pleural metastasis of lung adenocarcinoma is a common clinical problem with severe implications, since it is a debilitating condition associated with high morbidity, poor prognosis and low life expectancy (3-15 months) [ 1 - 6 ]. (biomedcentral.com)
  • Touch print cytology shows higher sensitivity than pleural lavage cytology for pleural micro-metastasis in lung cancer. (semanticscholar.org)
  • So, if we have a method with higher sensitivity than lavage cytology, the significance of pleural micro-metastasis will be elucidated clearly. (semanticscholar.org)
  • Empyema is defined by frank pus in the pleural space. (clinicaladvisor.com)
  • Treatment goals in empyema include sterilization of pleural fluid, reexpansion of the lung, and restoration of normal lung function. (medscape.com)
  • Pleural empyema (abscess) - Pleurectomy with lung decortication. (bookinghealth.com)
  • Evaluating the positivity and degree of staining of the well-known mesothelial marker D2-40 could be applied to differentiate pleural SM from the sarcomatoid component of LSC, in addition to assessing clinical and radiological information. (nih.gov)
  • Malignant pleural effusion resulting mainly from pleural metastases of lung adenocarcinoma has clinical relevance, being a sign of poor prognosis and low life expectancy. (biomedcentral.com)
  • Progress in lung cancer treatment is hampered by a lack of diagnostic markers useful in clinical practice. (biomedcentral.com)
  • The purpose of this study was to evaluate the known molecular markers, LunX, CK19, CEA, VEGF-C and hnRNP A2/B1 , for their expression in lung cancer cells in peripheral blood and pleural fluid using real-time RT-PCR, with the ultimate goal of establishing a more reliable molecular diagnostic method as an adjunct to clinical decision-making. (biomedcentral.com)
  • See Small Cell Lung Cancer: Beating the Spread , a Critical Images slideshow, to help identify the key clinical and biologic characteristics of small cell lung cancer, the staging criteria, and the common sites of spread. (medscape.com)
  • Explore this Health Topic to learn more about pleural disorders, our role in research and clinical trials to improve health, and where to find more information. (cdc.gov)
  • This study investigated the clinical characteristics, survival and epidermal growth factor receptor (EGFR) gene (EGFR) mutation status of lung adenocarcinoma patients with MPE. (cdc.gov)
  • To address this gap, we investigated the clinical impact of NLR as a prognostic factor in MPE (mNLR) and a new scoring system that use NLRs in the serum and MPE (smNLR score) in lung cancer patients. (biomedcentral.com)
  • Seventy eight percent of these had circumscribed plaques and 22% diffuse pleural thickening that involved the costophrenic angle. (cdc.gov)
  • Linear multivariate analysis indicated that both circumscribed plaques and diffuse pleural thickening were significantly associated with decreases in FVC, but not with the FEV1/FVC ratio. (cdc.gov)
  • After adjusting for potential confounders such as age, exposure, latency, and pack years smoking, the effect of diffuse pleural thickening on FVC decrements was approximately twice that of circumscribed pleural plaques. (cdc.gov)
  • Usually, there is a 20 - 30 years latency period before pleural plaques appear. (renalandurologynews.com)
  • Patients with only pleural plaques are often asymptomatic with unremarkable physical examination. (renalandurologynews.com)
  • Real-time RT-PCR method was used to determine the expression level of MUC1 mRNA and CEA mRNA biomarkers in pleural fluid of patients and healthy people. (minervamedica.it)
  • use of extracellular vesicles (EVs) isolated from the pleural lavage, a proximal fuid in lung cancer patients, as a source of potential biomarkers. (udl.cat)
  • This results opens the avenue to the use of EV-associated miRNA of pleural fuids and lavages as an untapped source of biomarkers, and specifcally, identifes miRNA-1-3p, miRNA-144-5p and miRNA 150-5p as promising biomarkers of lung cancer diagnosis. (udl.cat)
  • Tension pneumothorax is a very large pneumothorax that may result in failure of the heart and the lungs. (cdc.gov)
  • Cross-section of normal lungs and lungs with pleurisy and pneumothorax. (cdc.gov)
  • Figure B shows lungs with pleurisy and a pneumothorax. (cdc.gov)
  • This can cause a pneumothorax or pleural effusion. (cdc.gov)
  • Almost 50% of the people with lung cancer develop a pleural effusion and the cancer that grows in the pleural space results in malignant pleural effusion. (onlinecancerguide.com)
  • OBJECTIVES The pleural invasion (PL) score is a useful prognostic indicator in lung cancer. (ebscohost.com)
  • Mona Mlika, Emna Braham, Sadok Boudaya, Adel Marghli and Faouzi Mezni, "The Prognostic Impact of Pleural Invasion in Lung Cancer According to the UICC Classification", Current Respiratory Medicine Reviews (2016) 12: 126. (eurekaselect.com)
  • However, no study has reported the prognostic impact of the NLR in malignant pleural effusion (MPE). (biomedcentral.com)
  • The new smNLR score is a useful and cost-effective prognostic factor in lung cancer patients with MPE. (biomedcentral.com)
  • The purpose of this study was to evaluate the prognostic value of angiogenic factor vascular endothelial growth factor (VEGF) and angiogenesis inhibitor endostatin in lung cancer patients with MPE, and investigate the relationship between these two kinds of agent. (koreascience.or.kr)
  • Circulating serum vascular endothelial growth factor is not a prognostic factor of non-small cell lung cancer. (koreascience.or.kr)
  • Pleural ultrasonography with evaluation of appropriate diaphragmatic respiratory movement can predict post-operative complications in patient undergoing lung cancer surgery. (clinicaltrials.gov)
  • Pleural effusion is a common finding in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients. (biomedcentral.com)
  • However, the effect of pleural effusion on gas exchange, respiratory mechanics and response to positive end-expiratory pressure (PEEP) in ALI/ARDS patients, during mechanical ventilation, has never been prospectively studied. (biomedcentral.com)
  • It can also occur spontaneously when the lining of the lungs suddenly develops a tear due to an inherent imperfection or an existing respiratory ailment. (insiderfaq.com)
  • In addition, the study showed that VATPP patients had more air leaks in their lungs and also suffered other respiratory complications. (prweb.com)
  • Methods Immunoprotein quantity of CEA, CA125, CA153 and CA199 was analyzed in pleural fluid and serum from patients with lung cancer (52 cases) and in pleural fluid from non cancerous patients (50 cases) by chemiluminescence. (cnki.com.cn)
  • In lung cancer patients, the levels of CEA, CA125, CA153 and CA199 in pleural fluid were obviously higher than those in serum ( P 0.01 or P 0.05). (cnki.com.cn)
  • Vascular endothelial growth factor in the serum of patients with nonsmall cell lung cancer: correlation with platelet and leukocyte counts. (koreascience.or.kr)
  • Mesothelin biomarker in serum and/or pleural fluid may serve as adjuvant diagnostic tool with high specificity but low sensitivity. (renalandurologynews.com)
  • M alignant pleural effusion (MPE) can be a debilitating manifestation of metastatic cancer-and with patients living longer than ever, treatment for pleural effusion must also be longer-term and thoughtful in its approach. (tlc-newsletter.org)