Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Pathological processes involving any part of the LUNG.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Tumors or cancer of the LUNG.
Injuries incurred during participation in competitive or non-competitive sports.
An abnormal increase in the amount of oxygen in the tissues and organs.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
The transference of either one or both of the lungs from one human or animal to another.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Infection of the lung often accompanied by inflammation.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
General or unspecified injuries involving the leg.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC
Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Mechanical devices used to produce or assist pulmonary ventilation.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)
General or unspecified injuries to the chest area.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
General or unspecified injuries involving organs in the abdominal cavity.
General or unspecified injuries involving the arm.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
The circulation of the BLOOD through the LUNGS.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
General or unspecified injuries to the hand.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid.
Injuries involving the vertebral column.
Injuries to the knee or the knee joint.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Measurement of oxygen and carbon dioxide in the blood.
General or unspecified injuries to the heart.
Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).
A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
General or unspecified injuries to the soft tissue or bony portions of the face.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
Elements of limited time intervals, contributing to particular results or situations.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
General or unspecified injuries to the posterior part of the trunk. It includes injuries to the muscles of the back.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and dura mater. This frequently results in mechanical injury being transmitted to intracranial structures which may produce traumatic brain injuries, hemorrhage, or cranial nerve injury. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)
Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as "soft tissue injuries of the hand".
Injuries caused by impact with a blunt object where there is no penetration of the skin.
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
Injuries sustained from incidents in the course of work-related activities.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Injuries to the PERIPHERAL NERVES.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Harm or hurt to the ankle or ankle joint usually inflicted by an external source.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Injuries resulting in hemorrhage, usually manifested in the skin.
The posture of an individual lying face down.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Ventilatory support system using frequencies from 60-900 cycles/min or more. Three types of systems have been distinguished on the basis of rates, volumes, and the system used. They are high frequency positive-pressure ventilation (HFPPV); HIGH-FREQUENCY JET VENTILATION; (HFJV); and high-frequency oscillation (HFO).
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Disease having a short and relatively severe course.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Wounds caused by objects penetrating the skin.
General or unspecified injuries involving the foot.
General or unspecified injuries involving the fingers.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Deeply perforating or puncturing type intraocular injuries.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Refers to animals in the period of time just after birth.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
The force per unit area that the air exerts on any surface in contact with it. Primarily used for articles pertaining to air pressure within a closed environment.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The dialdehyde of malonic acid.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
Multiple physical insults or injuries occurring simultaneously.
The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.
Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.
Hyperextension injury to the neck, often the result of being struck from behind by a fast-moving vehicle, in an automobile accident. (From Segen, The Dictionary of Modern Medicine, 1992)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Relatively complete absence of oxygen in one or more tissues.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Injury following pressure changes; includes injury to the eustachian tube, ear drum, lung and stomach.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.
Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Disruption of structural continuity of the body as a result of the discharge of firearms.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
The measurement of an organ in volume, mass, or heaviness.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Substances that reduce or suppress INFLAMMATION.
Epithelial cells that line the PULMONARY ALVEOLI.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Head injuries which feature compromise of the skull and dura mater. These may result from gunshot wounds (WOUNDS, GUNSHOT), stab wounds (WOUNDS, STAB), and other forms of trauma.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
The excision of lung tissue including partial or total lung lobectomy.
Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.
Hospital units providing continuous surveillance and care to acutely ill patients.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Techniques for supplying artificial respiration to a single lung.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A malignant epithelial tumor with a glandular organization.
Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Diving and the risk of barotrauma. (1/841)

STUDY OBJECTIVES: Pulmonary barotrauma (PBT) of ascent is a feared complication in compressed air diving. Although certain respiratory conditions are thought to increase the risk of suffering PBT and thus should preclude diving, in most cases of PBT, risk factors are described as not being present. The purpose of our study was to evaluate factors that possibly cause PBT. DESIGN: We analyzed 15 consecutive cases of PBT with respect to dive factors, clinical and radiologic features, and lung function. They were compared with 15 cases of decompression sickness without PBT, which appeared in the same period. RESULTS: Clinical features of PBT were arterial gas embolism (n = 13), mediastinal emphysema (n = 1), and pneumothorax (n = 1). CT of the chest (performed in 12 cases) revealed subpleural emphysematous blebs in 5 cases that were not detected in preinjury and postinjury chest radiographs. A comparison of predive lung function between groups showed significantly lower midexpiratory flow rates at 50% and 25% of vital capacity in PBT patients (p < 0.05 and p < 0.02, respectively). CONCLUSIONS: These results indicate that divers with preexisting small lung cysts and/or end-expiratory flow limitation may be at risk of PBT.  (+info)

Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. (2/841)

BACKGROUND: Despite the advent of dialysis, survival with acute renal failure when associated with multiorgan failure is poor. The development of lung injury after shock or visceral ischemia has been shown; however, the effects of isolated renal ischemia/reperfusion injury (IRI) on the lungs are unclear. We hypothesized that isolated renal IRI could alter pulmonary vascular permeability (PVP) and that macrophages could be important mediators in this response. METHODS: Rats (N = 5 per group) underwent renal ischemia for 30 minutes, followed by reperfusion. Lung vascular permeability was evaluated by quantitation of Evans blue dye extravasation from vascular space to lung parenchyma at 1, 24, 48, or 96 hours after reperfusion. Serum was collected for blood urea nitrogen and creatinine at each time point. To examine the role of the macrophage, the macrophage pacifant CNI-1493, which inhibits the release of macrophage-derived inflammatory products, was administered in a blinded fashion during renal IRI. RESULTS: PVP was significantly (P < 0.05) increased at 24 hours and peaked at 48 hours after IRI compared with shams as well as baseline levels. PVP after IRI became similar to shams after 96 hours. This correlated with increases in blood urea nitrogen and creatinine at similar time points. At 48 hours, CNI-1493 significantly abrogated the increase in PVP compared with IRI alone. However, CNI-1493 did not alter the course of the acute renal failure. Pulmonary histology demonstrated interstitial edema, alveolar hemorrhage, and red blood cell sludging after renal IRI, which was partially attenuated by CNI-1493. CONCLUSIONS: Increased PVP develops after isolated renal IRI, and macrophage-derived products are mediators in this response. These findings have implications for understanding the mechanisms underlying respiratory dysfunction associated with acute renal failure.  (+info)

Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia. (3/841)

Exposure of adult rats to 100% O(2) results in lung injury and decreases active sodium transport and lung edema clearance. It has been reported that beta-adrenergic agonists increase lung edema clearance in normal rat lungs by upregulating alveolar epithelial Na(+)-K(+)-ATPase function. This study was designed to examine whether isoproterenol (Iso) affects lung edema clearance in rats exposed to 100% O(2) for 64 h. Active Na(+) transport and lung edema clearance decreased by approximately 44% in rats exposed to acute hyperoxia. Iso (10(-6) M) increased the ability of the lung to clear edema in room-air-breathing rats (from 0.50 +/- 0.02 to 0.99 +/- 0. 05 ml/h) and in rats exposed to 100% O(2) (from 0.28 +/- 0.03 to 0. 86 +/- 0.09 ml/h; P < 0.001). Disruption of intracellular microtubular transport of ion-transporting proteins by colchicine (0. 25 mg/100 g body wt) inhibited the stimulatory effects of Iso in hyperoxia-injured rat lungs, whereas the isomer beta-lumicolchicine, which does not affect microtubular transport, did not inhibit active Na(+) transport stimulated by Iso. Accordingly, Iso restored the lung's ability to clear edema after hyperoxic lung injury, probably by stimulation of the recruitment of ion-transporting proteins (Na(+)-K(+)-ATPase) from intracellular pools to the plasma membrane in rat alveolar epithelium.  (+info)

Inhaled NO preadministration modulates local and remote ischemia-reperfusion organ injury in a rat model. (4/841)

Inhaled nitric oxide (iNO) has been shown to have a protective effect in lung ischemia-reperfusion (I/R)-induced injuries. We studied the role of iNO (10 parts/million for 4 h) administered before I/R. In an isolated perfused lung preparation, iNO decreased the extravascular albumin accumulation from 2,059 +/- 522 to 615 +/- 105 microl and prevented the increase in lung wet-to-dry weight ratio. To study the mechanisms of this prevention, we evaluated the role of nitric oxide (NO) transport and lung exposure with matched experiments by using either lungs or blood of animals exposed to iNO and blood or lungs of naive animals. iNO-exposed blood with naive lungs did not limit the extravascular albumin accumulation (2,561 +/- 397 microl), but iNO-exposed lungs showed a leak not significantly different from the group in which both lungs and blood were iNO exposed (855 +/- 224 vs. 615 +/- 105 microl). An improvement in heart I/R left ventricular developed pressure in the animals exposed to iNO showed that blood-transported NO was, however, sufficient to trigger remote organ endothelium and reduce the consequences of a delayed injury. In conclusion, preventive iNO reduces the consequences of lung I/R injuries by a mechanism based on tissue or endothelium triggering.  (+info)

ICAM-1 and CD11b inhibition worsen outcome in rats with E. coli pneumonia. (5/841)

We investigated whether inhibiting an endothelial adhesion molecule [intracellular adhesion molecule 1 (ICAM-1)] would alter outcome and lung injury in a similar fashion to inhibition of a leukocyte adhesion molecule (integrin CD11b) in a rat model of gram-negative pneumonia. Inhibition of ICAM-1 with monoclonal antibody (MAb) 1A29 (1 mg/kg sc or 0.2 or 2 mg/kg iv, q 12 h x 3) or of CD11b with MAb 1B6 (1 mg/kg sc, q 12 h x 3) were compared against similarly administered placebo proteins in rats challenged with intrabronchial Escherichia coli. After challenge, all animals were treated with antibiotics. ICAM-1 MAb (6 mg/kg, iv, total dose) increased mortality vs. control (P = 0.03). CD11b MAb (3 mg/kg, sc, total dose) did not significantly (P = 0.16) increase mortality rates, but this was not in a range of probability to exclude a harmful effect. All other doses of MAb had no significant effect on survival rates. ICAM-1 and CD11b MAbs had significantly different effects on the time course of lung injury, circulating white cells and lymphocytes, and lung lavage white cells and neutrophils (P = 0.04-0.003). CD11b MAb decreased, whereas ICAM-1 MAb increased these measures compared with control from 6 to 12 h after E. coli. However, from 144 to 168 h after E. coli both MAbs increased these measures compared with control rats but to a greater level with CD11b MAb. Thus both ICAM-1 and CD11b appear to be necessary for survival during E. coli pneumonia. Although these adhesion molecules may participate differently in early lung injury, with CD11b increasing and ICAM-1 decreasing inflammation and injury, both are important for the resolution of later injury. During gram-negative pneumonia the protective roles of ICAM-1 and CD11b may make their therapeutic inhibition difficult.  (+info)

Intratracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits. (6/841)

To evaluate the role of tumor necrosis factor (TNF)-alpha in the pathogenesis of ventilator-induced lung injury, we 1) measured TNF-alpha production in the lung caused by conventional mechanical ventilation (CMV) and 2) evaluated the protective effect of anti-TNF-alpha antibody (Ab) in saline-lavaged rabbit lungs. After they received saline lung lavage, rabbits were intratracheally instilled with 1 mg/kg of polyclonal anti-TNF-alpha Ab in the high-dose group (n = 6), 0.2 mg/kg of anti-TNF-alpha Ab in the low-dose group (n = 6), serum IgG fraction in the Ab control group (n = 6), and saline in the saline control group (n = 7). Animals then underwent CMV for 4 h. Levels of TNF-alpha in lung lavage fluid were significantly higher after CMV than before in both control groups. Pretreatment with intratracheal instillation of high and low doses of anti-TNF-alpha Ab improved oxygenation and respiratory compliance, reduced the infiltration of leukocytes, and ameliorated pathological findings. CMV led to TNF-alpha production in the lungs, and intratracheal instillation of anti-TNF-alpha Ab attenuated CMV-induced lung injury in this model.  (+info)

Pressure is proinflammatory in lung venular capillaries. (7/841)

Endothelial responses may contribute importantly to the pathology of high vascular pressure. In lung venular capillaries, we determined endothelial [Ca(2+)](i) by the fura-2 ratioing method and fusion pore formation by quantifying the fluorescence of FM1-43. Pressure elevation increased endothelial [Ca(2+)](i). Concomitantly evoked exocytotic events were evident in a novel spatial-temporal pattern of fusion pore formation. Fusion pores formed predominantly at vascular branch points and colocalized with the expression of P-selectin. Blockade of mechanogated Ca(2+) channels inhibited these responses, identifying entry of external Ca(2+) as the critical triggering mechanism. These endothelial responses point to a proinflammatory effect of high vascular pressure that may be relevant in the pathogenesis of pressure-induced lung disease.  (+info)

Pulmonary and bronchial circulatory responses to segmental lung injury. (8/841)

In regional lung injury, pulmonary blood flow decreases to the injured regions, and anastomotic bronchial blood flow and total bronchial blood flow increase. However, the pattern of redistribution of the two blood flows to the injured and noninjured areas is not known. In six anesthetized sheep, pulmonary and bronchial blood flows were measured with 15-microm fluorescent microspheres by using the reference flow method. Blood flows were measured in the control state and 1 h after instilling 1 ml/kg of 0. 1 N hydrochloric acid into a dependent segment of the left lung. The lungs were then removed, dried, and cubed into approximately 2-cm cubes while spatial coordinates were noted. Blood flow to each piece was calculated. Mean pulmonary blood flow to the noninjured pieces went from 730 +/- 246 to 574 +/- 347 ml/min (P = 0.22), whereas in the injured pieces the pulmonary blood flow decreased from 246 +/- 143 to 56 +/- 46 ml/min (P < 0.01). In contrast, bronchial blood flow to the injured pieces increased from 0.51 +/- 0.1 to 1.43 +/- 0. 85 ml/min (P = 0.005). We measured the change in flow as it related to the distance from the center of the injured area. Pulmonary blood flow decreased most at the center of the injury, whereas bronchial blood flow doubled at the center of injury and decreased with the distance away from the injury. The absolute increase in bronchial blood flow was substantially less than the decrease in pulmonary blood flow in the injured pieces. We also partitioned the observed variation in pulmonary and bronchial blood flow into that attributable to structure and that due to lung injury and found that 48% of the variation in pulmonary blood flow could be attributed to structure, whereas in the bronchial circulation 70% was attributable to structure. The reasons for these differences are not known and may reflect the intrinsic properties of the systemic and pulmonary circulations.  (+info)

FIGURE 9. FRH-augmented cell death is not mediated by a soluble factor. A, The media of MLE-15 cells exposed to TNF-a and various incubation temperatures for 18 h was collected and transferred to MLE-15 cells and then incubated at 37˚C for 18 h. No difference in the cell survival at each conditioning dose of TNF-a exists, although a trend for increased mortality from the cell-conditioned media of cells at 34˚C exists. This reflects increased production (B) of and increased stability (C) of the TNF-a at 34˚C compared with 39.5˚C. - Epithelial Apoptosis a Mechanism of Enhanced Alveolar Lipopolysaccharide-Induced Lung Injury by Febrile-Range Hyperthermia Augments
PHILADELPHIA, March 11, 2013 /3BL Media/ - Once the initial episode of influenza has passed, the chronic effects tend to be overlooked. The results of a new study indicate that the cytokine interleukin-22 (IL-22) plays a critical role in normal lung repair following influenza infection. This study is published in the April 2013 issue of The American Journal of Pathology.. With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance, says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Childrens Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. A key finding is that even after the resolution of ...
Unlike Hills criteria, the US Surgeon General Expert Committee suggested to consider alternative explanations as a causality criteria. First of all, the possibility of fungi as a cause of lung injury. Although there were no other significant risk factors than HDs in the studies of lung injury, the first epidemiological study showed significant association between fungi at room reported by questionnaire administration with lung injury, even after adjustment for various variables [12]. Association with fungi was substantially small compared to association with the HDs; in addition, there was no consistency of results, as there was no significance in the analysis of different control groups. Furthermore, fungi were not detected in the patients specimen. Above all, there was no significant association between fungi and lung injury among the study in children and community-based case control study [12,13]. Thus, the possibility that fungi may be a direct cause of lung injury is very low, and it is ...
While legal challenges form just one half of the effort to curb vaping-related injuries, medical providers are striving to better characterize and treat these illnesses. Such research is hampered by the unknown root cause of lung injury. Initial onset of vaping-related lung injuries can be hard to identify, with symptoms including fever, abdominal pain, and diarrhea. Later onset of respiratory injuries is also expected in the form of these vaping-associated lung injuries, which may include coughing, nausea, watery diarrhea, and chest or abdominal pain. Yet, over 1,000 cases of vaping associated-lung injury have been reported without a specified cause since June 2019. In response to this ongoing outbreak, the Utah Department of Health conducted a case study to describe the correlation between vape use and associated lung injuries. They found that individuals who used e-cigarettes with THC cartridges, the active ingredient in marijuana, experienced disproportionately greater hospitalization and ...
The CDC recently announced some updates regarding lung diseases linked to use of vaping devices. If you were injured contact Elliott & Smith Law.
Cases of lung injuries in Stamford and Connecticut are similar to reports around the country involving e-cigarettes containing THC exclusively, a combination of nicotine and THC, or just nicotine, that have caused similar symptoms. However, the CDC found that the vast majority of lung injuries due to vaping come from cartridges that contain THC, which is the principal psychoactive component of cannabis.. ...
Currently, ALI and ARDS therapy focuses on the lungs to maintain gas exchange and minimize further injury. These researchers examined rats with lung injury and determined that the brain regions that control breathing are affected also. In fact, the characteristics of the pathologic breathing pattern remain even when the lungs are removed. In addition, inflammation was evident in the part of the brain that generates the breathing pattern. This indicates that the lungs are not the only factor involved in breathing disorders in lung injury ...
The Centres for Disease Control and Preventions (CDC) has updated its interim guidance for the evaluation and management of patients with suspected e-cigarette, or vaping-associated, lung injury (EVALI), based on the 1,299 cases reported as of October 8, 2019. The chemical(s) responsible for the lung injury have not yet been identified (Tetrahydrocannabinol or THC-containing
Lung injuries from vaping have been reported in all 50 states. Health officials have reported 52 deaths nationwide due to vape lung injury.
Goldkorn, T, Chung, S & Filosto, S. (2013) Lung cancer and lung injury: the dual role of ceramide. Handb Exp Pharmacol. 2013 Apr 8;(216):93-113. PM ID: ...
The patients, most of them young, began showing up at hospitals in the spring 2019. Some were coughing, out of breath or feverish. Some were vomiting or had diarrhea. Some ended up in intensive care, needing oxygen. Some died. They had been vaping, and their condition acquired the name EVALI, for e-cigarette or vaping product use-associated lung injury. In simple terms, its a miserable experience, said a doctor who saw several EVALI patients.
As of December 17, there were 2,506 hospitalized cases of lung injury linked to vaping in the United States, the US Centers for Disease Control and Prevention s...
There were 2,506 hospitalized cases of lung injury linked to vaping in the United States as of December 17, the US Centers for Disease Control and Prevention said on Thursday.
E-cigarette use can harm the lungs. Eight Wisconsin teens who developed severe lung injuries after vaping may be the latest victims.
Vaping devices, introduced to the US market in 2007 as aids for smoking cessation, have become popular among youth and young adults because of their enticing flavors and perceived lack of negative health effects. However, evidence is emerging that vaping may introduce high levels of dangerous chemicals into the body and cause severe lung injury and death. This article reviews the history and prevalence of vaping and available research on its health effects and efficacy in smoking cessation, and proposes recommendations for clinicians and legislators to reduce harms associated with vaping. ...
Hundreds more Americans have been sickened by a mysterious vaping-related lung disease, and the death toll has risen to 18, according to federal health data released Thursday.
A balancing act between transcriptional activators and repressors appears to play a key role in maintaining tissue homeostasis....
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.
The number of people who have died from a vaping-related lung injury has risen to 34, up one from last week, according to the Centers for Disease Control and Prevention.
TY - JOUR. T1 - Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA. AU - Rafikov, Ruslan. AU - Dimitropoulou, Christiana. AU - Aggarwal, Saurabh. AU - Kangath, Archana. AU - Gross, Christine. AU - Pardo, Daniel. AU - Sharma, Shruti. AU - Jezierska-Drutel, Agnieszka. AU - Patel, Vijay. AU - Snead, Connie. AU - Lucas, Rudolf. AU - Verin, Alexander. AU - Fulton, David. AU - Catravas, John D.. AU - Black, Stephen M.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2014/2/21. Y1 - 2014/2/21. N2 - Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.. AB - Background: The activation ...
A pulmonary contusion, also known as lung contusion, is a bruise of the lung, caused by chest trauma. As a result of damage to capillaries, blood and other fluids accumulate in the lung tissue. The excess fluid interferes with gas exchange, potentially leading to inadequate oxygen levels (hypoxia). Unlike pulmonary laceration, another type of lung injury, pulmonary contusion does not involve a cut or tear of the lung tissue. A pulmonary contusion is usually caused directly by blunt trauma but can also result from explosion injuries or a shock wave associated with penetrating trauma. With the use of explosives during World Wars I and II, pulmonary contusion resulting from blasts gained recognition. In the 1960s its occurrence in civilians began to receive wider recognition, in which cases it is usually caused by traffic accidents. The use of seat belts and airbags reduces the risk to vehicle occupants. Diagnosis is made by studying the cause of the injury, physical examination and chest ...
TY - JOUR. T1 - Effect of phorbol myristate acetate-induced lung injury on airway blood flow. AU - Barman, Scott A. AU - Ardell, J. L.. AU - Taylor, A. E.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The effects of phorbol myristate acetate (PMA) induced lung injury on the pulmonary and systemic blood flow contributions to the trachea and main bronchi (upper airways) were assessed in anesthetized dogs by injecting 15 μm radiolabeled microspheres into the right and left heart, respectively. Upper airway blood flow was studied in lungs given the following treatments: (1) PMA; (2) PMA in lungs pretreated with the thromboxane synthetase inhibitor OKY-046, and (3) PMA in lungs pretreated with the antioxidant catalase. After microsphere injections, the tracheal cartilage, tracheal muscle-mucosa, and main bronchi were excised. The results of this study indicate that under normal conditions, tracheal mucosa [33-52 ml·min-·(100 g)-1] and tracheal cartilage [18-27 ml·min-1·(100 g)-1] blood flow is primarily ...
Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have shown that Semaphorin 7A (SEMA7A) promotes inflammation, there are limited reports regarding immunological function of SEMA7A in seawater aspiration-induced ALI. Therefore, we investigated the role of SEMA7A during seawater aspiration-induced ALI. Male Sprague-Dawley rats were underwent seawater instillation. Then, lung samples were collected at an indicated time for analysis. In addition, rat pulmonary microvascular endothelial cells (RPMVECs) were cultured and then stimulated with 25% seawater for indicated time point. After these treatments, cells samples were collected for analysis. In vivo, seawater instillation induced lung histopathologic changes, pro-inflammation cytokines release and increased expression of SEMA7A. In vitro, seawater stimulation led to pro-inflammation cytokine release, cytoskeleton remodeling and increased monolayer permeability in pulmonary
Request for Free Sample Report: https://www.delveinsight.com/sample-request/acute-lung-injury-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Acute Lung Injury. 3. Competitive Intelligence Analysis for Acute Lung Injury. 4. Acute Lung Injury: Market Overview at a Glance. 5. Acute Lung Injury: Disease Background and Overview. 6. Patient Journey. 7. Acute Lung Injury Epidemiology and Patient Population. 8. Treatment Algorithm, Current Treatment, and Medical Practices. 9. Unmet Needs. 10. Key Endpoints of Acute Lung Injury Treatment. 11. Marketed Products. List to be continued in report. 12. Emerging Therapies. List to be continued in report. 13. Acute Lung Injury: Seven Major Market Analysis. 14. Attribute analysis. 15. 7MM: Market Outlook. 16. Access and Reimbursement Overview of Acute Lung Injury. 17. KOL Views. 18. Market Drivers. 19. Market Barriers. 20. Appendix. 21. DelveInsight Capabilities. 22. Disclaimer. 23. About DelveInsight. About DelveInsight ...
Medical information, Acute lung injury. Definition of Acute lung injury, symptoms of Acute lung injury, treatment of Acute lung injury, and prevention of Acute lung injury. Exams and Tests Acute lung injury.
Objective:Although ventilation with small tidal volumes is recommended in patients with established acute lung injury, most others receive highly variable tidal volume aimed in part at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury, which develops after the in
The report titled, Acute Lung Injury Treatment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025 by TMR Research furnishes an in-depth analysis of the vital catalysts and deterrents of the global market for acute lung injury treatment, alongside accurate figures, charts, diagrams, and graphs. The report offers an insightful assessment of the leading geographical segments and the growth opportunities offered by each of them. Acute lung injury is a prominent cause of morbidity and mortality across the world. Since one of the common conditions that is associated with severe hypoxia is acute lung injury, acute lung injury treatment market is expected to soar as its incidence keeps escalating worldwide, augmenting mortality rates. Researchers can now have access to critical information pertaining to the pathophysiology of the condition as well as numerous biological markers related to worse clinical outcomes of patients, thanks to the recent technological ...
Comment on Assessment of Aspiration-Induced lung Injuries among Acute Drug Poisoning Patients; Loghman Hakim Hospital, Poisoning center
Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell infiltration, activation and inflammatory cytokine release, enhancing basal alveolar fluid clearance and improving alveolar capillary barrier function.The Beta Agonist Lung Injury TrIal (prevention) is a multi-centre, randomised, double blind, placebo-controlled trial. The aim of the trial is to determine in patients undergoing elective transthoracic oesphagectomy, if treatment with inhaled salmeterol 100 mcg twice daily started at induction of anaesthesia and continued for 72 hours thereafter compared to placebo affect the incidence of early acute lung injury and other clinical, resource and patient focused outcomes. The primary outcome will be the development of acute lung injury within 72 hours of oesophagectomy. The trial secondary outcomes are the development of acute
TY - JOUR. T1 - Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. AU - Festic, Emir. AU - Ortiz-Diaz, Enrique. AU - Lee, Augustine. AU - Li, Guangxi. AU - Kor, Daryl J.. AU - Adebola, Adesanya. AU - Akca, Ozan. AU - Hoth, Jason. AU - Levitt, Joseph E.. AU - Carter, Rickey. AU - Gajic, Ognjen. N1 - Funding Information: The work was supported in part by HL78743-01A1 , 1 KL2 RR024151 , and the Mayo Clinic Critical Care Research Committee . PY - 2013/12. Y1 - 2013/12. N2 - Purpose: Inhaled corticosteroids (ICSs) attenuated lung injury in animal studies. We investigated the association between prehospital ICS and incidence of acute lung injury (ALI) among patients at risk. Methods: In this ancillary analysis of the large multicenter Lung Injury Prediction Study cohort, we developed a propensity score for prehospital ICS use followed by matching, for all patients and for a subgroup of patients with at least 1 risk factor for direct pulmonary injury. The ...
GlobalDatas clinical trial report, Acute Lung Injury Global Clinical Trials Review, H2, 2012 provides data on the Acute Lung Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Acute Lung Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Acute Lung Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts. Note: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.
BACKGROUND: Platelet-activating factor is a mediator of lung injury during cardiac operation. Platelet-activating factor antagonists reduce lung injury in animal models of cardiopulmonary bypass but there is no confirmatory evidence in clinical practice. METHODS: The effect of a low or high dose of a platelet-activating factor antagonist (Lexipafant) was assessed in a single center, double-blind, placebo-controlled, parallel group study. One hundred fifty patients undergoing coronary artery bypass grafting were randomized by minimization into three groups to receive placebo infusion, 10 or 100 mg of lexipafant for over 24 hours. Serial arterial oxygen and carbon dioxide tension, alveolar arterial oxygen gradient, and percent saturation were measured before operation and at 1, 6, 24, 48 hours, and 5 days after operation. RESULTS: Patient groups were similar with respect to age, sex, body surface area, and urgency of operation. Likewise, the groups were similar with respect to duration of cardiopulmonary
Ventilator-induced lung injury (VILI) contributes to mortality in ARDS. Particularly preinjured lungs are susceptible to VILI despite protective ventilation. We previously observed protection against VILI by Adrenomedullin (AM). Here we analyzed impact VILI on lung injury, pulmonary and systemic inflammation, bacterial burden and end-organ injury in established pneumonia. Further AM therapy was investigated.. 24h after infection with S. pneumoniae mice were subjected to MV (12ml/kg, 6h) and AM treatment. Lung permeability, oxygenation, lung mechanics, lung and plasma cytokines and leukocytes, bacterial burden in lung, blood spleen, ALT, AST, creatinine and urine output were assessed. Expression of AM and its receptor complex (CRLR; RAMP1-3) were studied. In pneumonia MV aggravated lung injury indicated by increased pulmonary permeability, oxygenation failure and worsening of lung mechanics. MV dramatically increased lung and blood cytokine levels in pneumonia, while lung leukocyte counts in ...
Cerrar Maskara S Sen N et al. Correlation between lung injury score and serum albumin levels in patietns at risk for developing acute lung injury. Nutrition. 2000; 16: 91-94 ...
Cross-Species, Cross-Platform, Meta-Analysis of Acute Lung Injury (ALI) and Ventilator Induced Lung Injury (VILI) Microarrays Conference Paper ...
With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance, says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Childrens Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. A key finding is that even after the resolution of infection, influenza results in lung parenchymal remodeling that may be critical to susceptibility to further injury, says Dr. Alcorn. This series of experiments used 6- to 8-week-old wild-type (WT) mice (C57BL/6 strain) as well as IL-22-deficient mice, infected with influenza A PR/8/34 H1N1 or control vehicle. To determine the distribution of IL-22 in the lung, they used ...
Expression analysis, microscopy, chromatin immunoprecipitation, electrophoretic mobility shift assays, and VE-cadherin-luciferase reporter experiments demonstrated that KLF4 interacted with specific domains of VE-cadherin promoter and regulated the expression of VE-cadherin at AJs. KLF4 knockdown disrupted the endothelial barrier, indicating that KLF4 is required for normal barrier function. In vivo studies in mice showed augmented lipopolysaccharide-induced lung injury and pulmonary edema following Klf4 depletion.. ...
Anti-inflammatory effects of methanol extract of Canarium lyi C.D.Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury / Ju Mi Hong; Ok-Kyoung Kwon; In Sik Shin; Chan Mi Jeon; Na Rae Shin; Joongku Lee; Sang-Hong Park; T Bach; D V Hai; Sei-Ryang Oh; S B Han; Kyung Seop Ahn , 2015 ...
Latest Infectious Disease News By Peter Schelden on 02/21/2020 3:43 PM Source: MedicineNet Health News As the global death toll tops 2,100, COVID-19 infections continue to spread in countries across the world, including in the U.S. The region with the most infections is the West Coast, with 11 confirmed cases out of 15 total. In comparison, the East Coast has confirmed only one case. There are nine confirmed COVID-19 cases in California, including one patient recently evacuated from the Diamond Princess cruise ship in Japan. Another case was reported last week in Arizona involving a man in his 20s, according to The Arizona Republic. The first confirmed case in the U.S. appeared in Washington state. Other people have tested positive elsewhere in the US. Two cases have been confirmed in Illinois, one in Wisconsin, and one in Texas. The only East Coast state with any confirmed COVID-19 cases is Massachusetts, which reported a Boston man in his 20s was infected earlier this month. An additional 13 ...
Invading pathogens may trigger overactivation of the innate immune system, which results in the release of large amounts of proinflammatory cytokines (cytokine storm) and leads to the development of pulmonary edema, multiorgan failure, and shock. PIAS1 is a multifunctional and potent anti-inflammatory protein that negatively regulates several key inflammatory pathways such as Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and nuclear factor κB (NF-κB). We discovered a ubiquitin E3 ligase, HECTD2, which ubiquitinated and mediated the degradation of PIAS1, thus increasing inflammation in an experimental pneumonia model. We found that GSK3β phosphorylation of PIAS1 provided a phosphodegron for HECTD2 targeting. We also identified a mislocalized HECTD2 polymorphism, HECTD2A19P, that was present in 8.5% of the population and functioned to reduce inflammation. This polymorphism prevented HECTD2/PIAS1 nuclear interaction, thus preventing PIAS1 degradation. The HECTD2A19P ...
BACKGROUND: Major burns can alter the pharmacokinetics of opiate analgesics, which are commonly used perioperatively. Fentanyl undergoes a significant amount of pulmonary pharmacokinetic transition. This study was conducted to compare the pharmacokinetics of fentanyl in major burns, with and without lung injury, during the subacute hyperdynamic phase of recovery. METHODS: Twelve adults, with total body surface area (TBSA) 51.0 +/- 11.8% burns, aged 34.9 +/- 9.6 years, with a lung injury related to the burn, were studied at 15.4 +/- 9.4 days after the injury. Another 8 patients, aged 39.8 +/- 10.5 years, with TBSA 46.3 +/- 19.4%, at 19.3 +/- 10.9 days, without lung injury, served as controls. Fentanyl 200microgram was given intravenously over 10 seconds. Blood samples (n = 20) were collected at predetermined intervals. A two-compartment model was used for pharmacokinetic analyses of the fentanyl concentrations, as determined by LC/MS. The cardiac index (CI) was also measured using an esophageal ...
Acute lung injury (ALI) is an example of a critical care syndrome with limited treatment options once the condition is fully established.Not surprisingly, many treatments targeting the mechanisms identified in preclinical studies have failed to improve patient outcomes.The most likely reason could be due to inadequate and delayed recognition of patients at risk and the subsequent development of the full blown syndrome.ALI/ARDS usually develops during the first hours of ICU admission, and often is the very reason for ICU admission.. Clinical prediction models have been extensively used in the clinical practice to identify patients at high risks who may benefit from specific interventions. However, no such tool exists to predict the development of ALI in patients at risk. We have recently developed an ALI prediction model (Lung Injury Prediction Score:LIPS)which incorporates demographic, environmental and clinical characteristics at the time of, and before, hospital admission. If validated, this ...
The purpose of the study is to identify the patients at high risk of developing Acute Lung Injury (ALI) at the time of hospital admission, and before intensive care unit admission.. Aim 1- To validate the prediction model (Lung Injury Prediction Score) in a population based sample of hospitalized patients.. Aim 2- To determine the significance of health-care related ALI risk modifiers in a population based sample.. Aim 3- To compare the short and long term outcomes between patients at high risk who do, and do not develop ALI.. ...
Acute Lung Injury - Pipeline Review, H2 2014 Summary Global Markets Directs, Acute Lung Injury - Pipeline Review, H2 2014, provides an overview of the Acute
Introduction Although activation of A3adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. Adenosine...
Background: Resistin-like molecule-α (RELMα) has diverse regulatory functions in inflammation, but its role in severe acute pancreatitis (SAP) and acute pancr
The events of the 2009 influenza pandemic sparked discussion regarding the need to optimize delivery of care to those most severely ill.
While the exact cause is yet to be determined, it definitely appears to be caused by e-cigarettes. The CDC (Center for Disease Control) has been investigating. At this point, the CDC is strongly advising against using any of these products. Now that the problems have come to the attention of federal agencies the investigations are progressing as fast as possible ...
Chief Investigator:. Miss Elena Cavallaro. Funding Amount:. $34,874. Recipient:. Flinders University. Overview:. Bronchiolitis and pneumonia are leading causes of infant hospitalisation in Australia. The exaggerated immunological insult stemming from these infections on developing lungs is associated with early-childhood asthma development. We have used a small protein, feG, to reduce the consequences of acute lung injury in various adult animal models, by dampening the immune response. We aim to assess feG efficacy in reducing the short and long-term effects of bronchiolitis and pneumonia during infancy, where feG may be an ideal candidate for returning the balance of the immune response in the airways.. ...
With modern therapy many patients are surviving an initial episode of acute lung injury (ALI). A patient surviving ALI may have a recurrent episode, which oftens has a high mortality rate. Therefore it is important to identify and correct any possible contributory factors.
Aim: This study was to observe the changes of the gene expression of microRNA-155 and 127 in the neonatal rats with Acute Lung Injury (ALI). Methods:..
... local vendors of Global Acute Lung Injury Market, some of them are GSK, Altor BioScience Corp, Faron Pharmaceuticals Oy, Altor BioScience Corp, APEPTICO,
Human CD34+ Progenitor Cells Freshly Isolated from Umbilical Cord Blood Attenuate Inflammatory Lung Injury following Lipopolysaccharide Challenge
Sigma-Aldrich offers abstracts and full-text articles by [Hongping Xia, Xiaomeng Ren, Craig S Bolte, Vladimir Ustiyan, Yufang Zhang, Tushar A Shah, Tanya V Kalin, Jeffrey A Whitsett, Vladimir V Kalinichenko].
Prometic announced today that it will be presenting new data at the 2017 American Thoracic Society International Conference in Washington, D.C.showing the benefits of plasminogen in lung injury.
The US has witnessed a spate of patients presenting with acute lung injury associated with e-cigarettes or vaping product use. A new study published in the journal JAMA Internal Medicine shows the pattern of the outbreak in California where recreational cannabis use is legal and which has among the maximum cases of the strange illness ...
A Canadian research team announced that it has found the reason for the appearance of pulmonary fibrosis in a number of lung cancer patients who underwent thoracic radiotherapy. They found a connection between genes on a certain chromosome and the development of lung injuries triggered by radiation. The researchers were investigating chromosome 6, one of the 23 pairs of DNA molecules found […]
Tassiopoulos AK, Carlin RE, Gao Y, Pedoto A, Finck CM, Landas SK, Tice DG, Marx W, Hakim TS, McGraw DJ. Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities. J Vascular Surg 26:647, 1997 ...
CDC officials found vitamin E acetate, an oil derived from the vitamin, in all 29 samples of lung fluid collected from patients who had fallen ill or died from lung injuries.. This story is from The Seattle Times. Read the rest of this News story at https://www.seattletimes.com/nation-world/nation/potential-culprit-found-in-vaping-related-lung-injuries-and-deaths/?utm_source=RSS&utm_medium=Referral&utm_campaign=RSS_seattle-news.. ...
Your rib cage protects them, but your lungs can still get injured. Learn the common causes of lung injuries and how theyre treated.
Minnesota health officials warned Friday of a possible resurgence of lung injuries related to vaping, saying theyve had 11 reported cases in the past two months.. Read More ». ...
Figure 3: The anti-inflammatory mechanism of omentin. Omentin activates AMPK, which further blocks E-selection and reduces endothelial inflammation. AMPK also activates eNOS, which has vasodilation effect and blocks JNK signaling. JNK activates inflammation through TNFα mediated COX2 effect. Moreover, omentin inhibits NF-κB signaling pathway and thus inhibits inflammation. Under obese state, the production of omentin is lower which is associated with worse proinflammation and possible lung injury ...
A newly recognized step in development of sepsis-induced lung injury looks like a promising therapeutic target, researchers suggested. Also this week: the need for light in utero.
Centers for Disease Control and Prevention says THC Products May Play a Role in Outbreak of Lung Injury Associated with E-cigarette Use, or Vaping | site |
The investigations of the multi-state outbreak of lung injuries related to vape has led to the discovery that they have often involved THC products, according to the CDC (Centers for Disease Control and Prevention), FDA (Food and Drug Administration) state and local health departments and other clinical/public health p
updated information about cases of e-cigarette, or vaping, product use-associated lung injury (EVALI): As of Nov. 12, there have been 2,172 cases reported
Vape pen lung injury: Heres what you need to know David DownsOctober 3, 2019 Share Print A suspected tainted black market vape cart seized in New York.
Sara M. Camp, Ermelinda Ceco, Carrie L. Evenoski, Sergei M. Danilov, Tong Zhou, Eddie T. Chiang, Liliana Moreno-Vinasco, Brandon Mapes, Jieling Zhao, Gamze Gursoy, Mary E. Brown, Djanybek M. Adyshev, Shahid S. Siddiqui, Hector Quijada, Saad Sammani, Eleftheria Letsiou, Laleh Saadat, Mohammed Yousef, Ting Wang, Jie Liang, and Joe G. N. Garcia. Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NF?B Signaling and Inflammatory Lung Injury, Scientific Reports, 2015, 14(5), 13135 ...

No data available that match "lung injury"

... product use associated lung injury (EVALI). Learn CDCs recommendations, and the latest outbreak information. ... Outbreak of Lung Injury Associated with E-cigarette Use, or Vapingplus icon*For Healthcare Providers ... As of February 18, 2020, a total of 2,807 hospitalized e-cigarette, or vaping, product use-associated lung injury (EVALI) cases ... If you have questions about CDCs investigation into the lung injuries associated with use of e-cigarette, or vaping, products ...
Acute Lung Injury Treatment Market is expected to grow healthy rate in near future; Acute lung injury is observed as a part of ... Acute Lung Injury Treatment Market report presents a detailed overview of the present scope of growth for companies operating; ... systemic inflammatory process wherein the lung manifests symptoms similar to other tissues such as destruction in capillary ... Global Acute Lung Injury Treatment Market: Insight into Key Aspects. Acute lung injury is a part of the systemic inflammatory ...
This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and ... Bacterial infections Hyperoxia LPS and bacterial pneumonia Transfusion-related acute lung injury Ventilator-induced lung injury ... Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are ... reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art ...
Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice. Exp Lung Res 1998; 24:721. ... Murine strain differences in acute lung injury and activation of poly(ADP-ribose) polymerase by in vitro exposure of lung ... Oxidative damage to the lung appears important in the pathophysiology of lung injury, and antioxidants may ameliorate the ... The pathogenesis and clinical aspects of bleomycin-induced lung injury will be reviewed here. Potential drug interactions that ...
... lung expression of CXCL1, CXCL2/3, and their receptor CXCR2 were accompanied by lung neutrophil infiltration and injury. ... reperfusion injury or acute lung injury (ALI) [1].. ALI and its more severe form acute respiratory distress syndrome (ARDS) are ... inhibition of CXCR2 led to a marked reduction in neutrophil sequestration and lung injury [17]. In bleomycin-induced lung ... "Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury," American ...
How syndromic data are used to characterize lung injury, inform public health decision making, and mitigate health risks. ... the Injury Center) to develop queries that could support CDCs ongoing multistate lung injury response. The NSSP and Injury ... NSSP Develops Queries to Support Lung Injury Response. ... Outbreak of Lung Illness Associated with Using E-cigarette ... to work closely with state and local health departments by providing tools to help them investigate a cluster of lung injuries ...
This report provides updated guidance regarding the management of patients presenting with suspected vaping-associated lung ... Lung Injury Response Clinical Working Group and Lung Injury Response Epidemiology/Surveillance Group 1National Center for ... even among patients with severe lung injury (personal communication, Lung Injury Response Clinical Working Group, October 2, ... If a lung biopsy or autopsy is performed on a patient suspected of lung injury related to e-cigarette, or vaping, product use, ...
Lung Injury Clinical Research Trial Listings in Pulmonary/Respiratory Diseases Trauma (Emergency, Injury, Surgery) Family ... Lung Injury Clinical Trials. A listing of Lung Injury medical research trials actively recruiting patient volunteers. Search ... lung. injury. (P-SILI) as a possible mechanism aggravating lung damage in these patients. The aim of this study is evaluate the ... lung. injury. at the start of surgery, intraoperative anesthetic and abdominal surgery interventions result in lung ...
Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. There is ... Cytokine-mediated inflammation in acute lung injury.. Goodman RB1, Pugin J, Lee JS, Matthay MA. ... and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, ... A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients ...
The number of people whove developed a severe form of lung disease potentially tied to vaping has now risen to 215 cases ... CDC Says Dont Vape As Lung Injury Cases Rise. FRIDAY, Aug. 30, 2019 (HealthDay News) -- The number of people whove ... In popcorn lung, the tiny air sacs in the lungs become scarred, resulting in the thickening and narrowing of the airways, the ... but its hard to say if theres going to be any long-term risk of lung injury or asthma or other illness," Wilson said. ...
... Ritesh Maharaj. Division of Intensive Care Medicine, Kings College Hospital, ... F. Michard, V. Zarka, S. Alaya, S. Sakka, and M. Klein, "Better characterization of acute lung injury/ARDS using lung water," ... Studies were searched in PUBMED by using the terms "extravascular lung water" (EVLW) and "acute lung injury" (ALI) or "acute ... Both experimental and clinical studies were searched in PUBMED using the term "extravascular lung water" and "acute lung injury ...
This review discusses the mechanisms and pathology underlying postoperative remote lung injury. What are potential preventative ... Predictions and Prevention for Postoperative Remote Lung Injury Postoperative remote lung injury and/or PPC are not uncommon ... Surgical Outcome of Patients With Postoperative Remote Lung Injury. *Predictions and Prevention for Postoperative Remote Lung ... Surgical Outcome of Patients With Postoperative Remote Lung Injury. *Predictions and Prevention for Postoperative Remote Lung ...
An injury to the lungs causes lung air sacs (alveoli) to fill with fluid. The result is severe shortness of breath and a ... Then the second phase sets in, during which the body tries to clean up the liquid mess in the lungs. Some are unable to meet ... Others get rid of the fluid but enter a third phase where there is deposition of scar tissue in the lungs. This leaves them ... The triggering injury can be a critical infection like sepsis (blood infection), pneumonia, chest trauma, smoke inhalation, ...
Mice that lacked natural killer T cells had increased amounts of monocytes in the lungs, and severe lung injury similar to ... Pneumoconiosis is a group of lung diseases caused by inhaled dust particles. It causes inflammation of the lungs leading to ... lead to lung injury at the end stage of severe flu infection. ... What Causes Lung Injury in Severe Flu?. by Thilaka Ravi on ... Silicosis is a lung disease caused by inhalation of crystalline free silica dust. It is characterised by nodular pulmonary ...
... , Transfusion Associated Acute Lung Injury, TRALI. ... Transfusion-Related Acute Lung Injury. Transfusion-Related Acute Lung Injury Aka: Transfusion-Related Acute Lung Injury, ... Transfusion-related acute lung injury, TRALI, Transfusion related acute lung injury (disorder), Transfusion related acute lung ... Results from immune mediated Neutrophil activation, endothelial injury, and capillary leak. *Acute Lung Injury is a result of ...
... Researchers uncover molecular reason why brain trauma sufferers are often poor donors for ... As a result, only 15 to 20% of the lungs are viable for transplant. To better understand why brain damage leads to lung damage ... chances are the donated organ will come from a person who suffered traumatic brain injury. Although the lungs of these donors ... The RAGE-less mice did not develop as much lung damage as the control group (Sci. Transl. Med. 2014, DOI: 10.1126/scitranslmed. ...
Studies of HPA axis activation and the role of relative adrenal insufficiency on the outcome of patients with acute lung injury ... relative adrenal insufficiency in patients with acute lung injury/ARDS is unknown. It is also unclear whether such a response, ... The National Heart, Lung, and Blood Institutes ARDS Network currently is testing the use of methylprednisolone in late ARDS. ... if present, predisposes patients to ongoing lung inflammation and the development of late fibroproliferative ARDS, or if it is ...
In this study, we have demonstrated that alveolar macrophages stimulated by bleomycin-induced injury secrete large quantities ... The findings in this study demonstrate that during bleomycin-induced injury, alveolar macrophages not only secrete large ... diminishing both the number of macrophages present in the alveoli and the total lung content of TGF-beta. However, the rate of ... before and concomitantly with bleomycin administration prevented the influx of alveolar macrophages into the lungs, ...
There were 2,172 cases of lung injury linked to vaping as of November 13, the US Centers for Disease Control and Prevention ... But the ages of those impacted by lung injury tend to be younger, with a median age of 24 and nearly 4 in 5 patients under 35. ... CNN - There were 2,172 cases of lung injury linked to vaping as of November 13, the US Centers for Disease Control and ... Lung injury cases now at 2,172, CDC says. Posted November 14, 2019 2:30 p.m. EST ...
Lung Injury. Respiration Disorders. Respiratory Tract Diseases. Pathologic Processes. Lung Diseases. Thoracic Injuries. ... Ulinastatin in Inhalation Lung Injury. The recruitment status of this study is unknown. The completion date has passed and the ... The purpose of this study is to evaluate the efficacy and effect of ulinastatin in inhalation lung injury patients. ... Multicenter,Randomized,Parallel Assignment,Blank Control Study of Ulinastatin in Inhalation Lung Injury. ...
Mechanisms underlying lung injury in EVALI. (A) In the panel on the left, cells of the lung are damaged by one chemical inhaled ... At the core of EVALI and COVID-19 is the clinical syndrome of acute lung injury (ALI), which is defined by injury to both ... Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010;23(4):243-252.. View this ... What are the mechanisms underlying vaping-induced lung injury?. Laura E. Crotty Alexander,1,2 Amy L. Bellinghausen,2 and ...
We excised the lungs and heart, inflated the lungs to 10 cm H2O, then perfused the lungs with 5 ml PBS followed by 5 ml 10% ... The injury signals were rapidly communicated to uninfected alveolar regions through GJs, accounting for widespread lung injury. ... Extravascular lung water and lung blood content. We determined blood-free lung water content by the method of Selinger and ... The MAs induced highly localized epithelial injury that spread through intercellular gap junctions (GJs), expanding lung injury ...
... implicating other MyD88-dependent pathways in lung injury following ischemia-reperfusion. We also found that left lung ischemia ... we hypothesized that lung ischemia-reperfusion injury was mediated by MyD88-dependent signaling. To test this hypothesis, we ... kidney and lung. Additionally, activation of TLRs other than TLR4 by DAMPs has been identified in tissues other than the lung. ... We found that Myd88-/- mice had significantly less MCP-1/CCL2 in the left lung following ischemia-reperfusion as compared with ...
... this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and… ... Acute Lung Injury: Etiologies and Basic Features. Cellular and Animal Models of Lung. Transgenic Models of Lung Injury and ... Mechanisms of Chronic Lung Injury and Fibrosis. Roles of Oxidants and Antioxidants in Lung. Vascular Dysfunction in Lung Injury ... Surfactant Dysfunction in Lung Injury. Ventilation Therapies and Strategies for Lung Injury. Anti-Inflammatory Therapies for ...
A TrkB agonist improved outcomes in vivo following lung injury. These data highlight the biological and therapeutic importance ... We used genome-wide analysis of chromatin accessibility and gene expression following acute lung injury to elucidate repair ... show that after injury or influenza infection alveolar type II cells signal via a STAT3-BDNF axis that activates the TrkB ... AT2 chromatin accessibility changed substantially following injury to reveal STAT3 binding motifs adjacent to genes that ...
Find facts about lung diseases, such as lung cancer, COPD, asthma. ... Learn how to improve your lung health. Make efforts towards clean air and smokefree living. ... What is LUNG FORCE?. LUNG FORCE unites women and their loved ones across the country to stand together in the fight against ... American Lung Association , 1-800-LUNGUSA (1-800-586-4872)1-800-LUNGUSA , Submit A Question , Live Chat ...
Read More: Vaping is leading to a spate of lung injuries, comas, and death. Lung experts say oils like vitamin E may be ... so it is largely meaningless for lung health. (At least one vaping-related lung injury was reported last year in the UK, which ... Trump wants to ban flavored vapes, but that might just worsen the vaping lung injury crisis. Hilary Brueck ... There's also no clear evidence that the lung injuries and deaths reported in the US are tied to any specific brand or ...
Acute lung injury (ALI), developing as a component of the systemic inflammatory response syndrome (SIRS), leads to significant ... NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome. American Journal of Physiology. Lung ... acute lung injury alveolar macrophage ARDS NADPH oxidase 2 Nox2 This is a preview of subscription content, log in to check ... Oxidant-mediated lung injury in the acute respiratory distress syndrome. Critical Care Medicine 27 (9): 2028-2030.CrossRef ...
... has shown that adult stem cells from bone marrow can help treat acute lung injury. Acute lung ... Acute lung injury (ALI) can be caused by any major inflammation or injury to the lungs and is a major cause of death in ... Acute lung injury? Stem cell therapy may help - Oct 30, 2009. *Bone marrow stem-cell therapy could treat acute lung injury: ... Tags: acute lung injury, adult stem cells, air sacs, blood vessels, bone marrow, cause of death, cd34, cell population, chicago ...
1.9M grant to study two proteins that play roles in acute lung injury, a condition which affects thousands of people each year. ... URMC receives $1.9M to study acute lung injury. Mar. 31, 2017 ... to identify viable therapies that will limit acute lung injury ... ALI occurs when capillary-alveolar barriers in the lung are disrupted, resulting in a variety of dangerous symptoms that can ... Fazals current study aims to understand how BiP and mortalin control the proinflammatory and leaky phenotype of the lung, and ...
  • Cytokine-mediated inflammation in acute lung injury. (nih.gov)
  • The respiratory symptoms appear to be caused by inflammation that causes the lungs to fill with fluid, said Dr. Karen Wilson, vice chair of clinical and translational research for pediatrics at the Icahn School of Medicine at Mount Sinai in New York City. (webmd.com)
  • It is also unclear whether such a response, if present, predisposes patients to ongoing lung inflammation and the development of late fibroproliferative ARDS, or if it is predictive of a beneficial response to steroids. (biomedsearch.com)
  • Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. (routledge.com)
  • 2013. NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults. (springer.com)
  • Acute lung injury (ALI) can be caused by any major inflammation or injury to the lungs and is a major cause of death in patients in hospital ICUs. (thaindian.com)
  • Their recently published study identified antioxidant effects in the potential functional food that can prevent destructive inflammation in lung tissue. (naturalnews.com)
  • The most widespread form of acute respiratory failure, its symptoms include the leakage of lung proteins, the concentration of inflammatory cells in lung tissue, and inflammation-causing cytokines and mediators flooding the organs. (naturalnews.com)
  • Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer's solution (vehicle control) thirty min before different ventilator strategies. (lifeboat.com)
  • Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV) of 15 mL/kg and zero positive end-expiratory pressure (PEEP) or a low TV of 6 mL/kg with PEEP of 5 cm H 2 O. We evaluated lung oxygenation, inflammation, mechanics, and histology. (lifeboat.com)
  • However, care strategies that minimize inflammation and ventilator-induced lung injury should help decrease BPD. (nih.gov)
  • It causes inflammation of the lungs leading to fibrosis. (medindia.net)
  • The lungs showed focal interstitial fibrosis, interstitial thickening, proliferation of macrophages in the alveoli, epithelioid changes in the interstitium, Type II cell hyperplasia, and foci of acute inflammation with consolidation. (bmj.com)
  • Ventilated patients with otherwise healthy lungs seldom develop ventilator-associated lung-injury while those with pulmonary inflammation are predisposed to such injury [5] , [6] . (plos.org)
  • Foxm1, a transcription factor of the Forkhead box family, is a critical mediator of lung development and carcinogenesis, but its role in BPD-associated pulmonary inflammation is unknown. (sigmaaldrich.com)
  • Measurements of lung function and flow cytometry were used to evaluate the effects of Foxm1 deletion on pulmonary inflammation and repair. (sigmaaldrich.com)
  • The exaggerated BPD-like phenotype observed in hyperoxia-exposed LysM-Cre/Foxm1(-/-) mice was associated with increased expression of neutrophil-derived myeloperoxidase, proteinase 3, and cathepsin g, all of which are critical for lung remodeling and inflammation. (sigmaaldrich.com)
  • The histological pattern of IPF is usual interstitial pneumonia (UIP), described as the patchy presence of denuded alveolar epithelium, fibroblastic foci and distortion of lung architecture leading to honeycombing with minimal inflammation. (ersjournals.com)
  • Methods In untreated mice (female C57/Bl6 mice, 11-15 weeks old) and animals treated with adrenomedullin, lung permeability, local and systemic inflammation and markers of distal organ function were assessed following 2 or 6 h of mechanical ventilation with 100% oxygen and protective or moderately injurious ventilator settings, respectively. (bmj.com)
  • 2 VILI is characterised by pulmonary inflammation with liberation of cytokines, recruitment of leucocytes to the lung and increased lung permeability, resulting in lung oedema, surfactant dysfunction, impaired lung compliance and deterioration of pulmonary gas exchange. (bmj.com)
  • 5 Moreover, the need for hyperoxic ventilation of preinjured lungs may further aggravate lung inflammation and barrier dysfunction. (bmj.com)
  • Acute Respiratory Distress Syndrome (ARDS) and a lesser condition that occurs prior to ARDS, Acute Lung Injury (ALI), are medical conditions that occur when there is severe inflammation and increased fluids (edema) in both lungs, making it hard for the lungs to function properly. (clinicaltrials.gov)
  • Aerosolized beta-2 agonist therapy is anticipated to diminish the formation of lung edema, enhance clearance of lung edema and decrease pulmonary inflammation in patients with acute lung injury. (clinicaltrials.gov)
  • RADS may persist for months or years following exposure, and pathogenesis likely includes airway epithelial injury, airway inflammation, and subsequent structural changes in the airways (airway fibrosis). (oncologynurseadvisor.com)
  • Direct radiation injury will be limited to areas that have received radiation, although patients can develop a hypersensitivity-type reaction to the radiation and can develop inflammation in the contralateral lung. (renalandurologynews.com)
  • Recently, we reported that PPIs suppress the expression of several proinflammatory and profibrotic molecules, as well as enhance antioxidant mechanisms in order to favorably regulate lung inflammation and fibrosis in an animal model of bleomycin-induced lung injury. (frontiersin.org)
  • Acute lung injury decreases the ability of the endothelial cells lining pulmonary blood vessels to be an effective barrier, resulting in the accumulation of fluid in the lungs (a condition called pulmonary edema) and inflammation. (sciencemag.org)
  • Tamoxifen-regulated deletion of both Foxf1 alleles in endothelial cells of adult mice ( Pdgfb-iCreER/Foxf1 −/− ) caused lung inflammation and edema, leading to respiratory insufficiency and death. (sciencemag.org)
  • The patient can inhale it, taking the drug directly into the lungs and to the point of inflammation. (fiercepharma.com)
  • The new nanoparticle from Queen's has a surface which allows it to recognize and bind to immune cells called macrophages in the lungs - key to the uncontrolled inflammation that occurs in ALI. (fiercepharma.com)
  • This binding induces a rapid reduction in the inflammation, and has the potential to prevent the damaging effects that will otherwise occur in the lungs of ALI patients. (fiercepharma.com)
  • Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). (mdpi.com)
  • In vivo , seawater instillation induced lung histopathologic changes, pro-inflammation cytokines release and increased expression of SEMA7A. (mdpi.com)
  • These results suggest that SEMA7A is critical in the development of lung inflammation and pulmonary edema in seawater aspiration-induced ALI, and may be a therapeutic target for this disease. (mdpi.com)
  • And while these materials have not been associated with adverse health effects in humans, research has found that multi-walled CNTs can cause pulmonary fibrosis and lung inflammation in animal models. (nanowerk.com)
  • However, the coating of aluminum oxide did not prevent lung inflammation. (nanowerk.com)
  • The role CXCR2 in lung inflammation in response to cigarette smoke (CS) inhalation using the mutant mouse approach is not known. (frontiersin.org)
  • Acute lung injury (ALI) comprises acute respiratory distress syndrome (ARDS), a grave and deadly form of acute lung injury, and other minor degrees of lung injuries. (tmrresearch.com)
  • Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. (springer.com)
  • Uncontrolled transmigration of PMNs into the interstitium of the lung and alveolar space is a pathologic hallmark of ALI/ARDS [ 7 ]. (hindawi.com)
  • Studies were searched in PUBMED by using the terms "extravascular lung water" (EVLW) and "acute lung injury" (ALI) or "acute respiratory distress syndrome" (ARDS) as keywords. (hindawi.com)
  • The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS. (biomedsearch.com)
  • The accuracy of the diagnostic criteria for, and the prevalence of, relative adrenal insufficiency in patients with acute lung injury/ARDS is unknown. (biomedsearch.com)
  • Both of these diseases have substantial gastrointestinal symptoms, bilateral lung infiltrates, and significant numbers of those affected progressing to hypoxic respiratory failure and acute respiratory distress syndrome (ARDS). (jci.org)
  • Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that further contributes to morbidity. (nature.com)
  • Acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are life-threatening lung conditions that affect more than 190,000 people in the United States each year, based on an estimate published in the October 20, 2005, NEJM. (innovations-report.com)
  • ALI/ARDS develops in patients who are critically ill with other diseases such as pneumonia or sepsis (severe and widespread bacterial infection), or who have sustained major injuries. (innovations-report.com)
  • Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). (lifeboat.com)
  • High frequency ventilation is thought to reduce ventilator-associated lung injury, especially in the context of ARDS and acute lung injury. (wikipedia.org)
  • Permissive hypercapnia and hypoxaemia allow the patient to be ventilated at less aggressive settings and can, therefore, mitigate all forms of ventilator-associated lung injury VALI is most common in people receiving mechanical ventilation for acute lung injury or acute respiratory distress syndrome (ALI/ARDS). (wikipedia.org)
  • 5 Acute lung injury and its more extreme form, ARDS, are both defined by the acute onset of hypoxemia and bilateral pulmonary infiltrates on chest radiography without clinical evidence of left atrial hypertension, but the entities differ in the degree of observed hypoxemia. (rtmagazine.com)
  • Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) represent a spectrum of clinical syndromes of rapid respiratory system deterioration that are associated with bot. (bioportfolio.com)
  • Abdominal muscle activity during mechanically ventilation is one of the injurious factors in severe acute respiratory distress syndrome (ARDS) and abdominal muscle paralysis might be an effective strategy to minimize ventilator-induced lung injury, according to research in Plos One . (rtmagazine.com)
  • No previous studies have proved the relationships between abdominal muscle and ventilator-associated lung injury in ARDS, researchers wrote. (rtmagazine.com)
  • In an oleic acid-induced ARDS model of male beagles, the study showed that BIPAP AP (abdominal muscle paralysis) had lower mRNA expression of interleukin-6 and IL-8 in lung tissues and less total cumulative histopathological lung injury scores compared with BIPAP SB (spontaneous breathing) group. (rtmagazine.com)
  • The end results are microvascular injury and diffuse alveolar damage with intrapulmonary hemorrhage, edema, and fibrin deposition ( 1 , 2 ), which are also features in patients with ALI and the acute respiratory distress syndrome (ARDS) ( 3 , 4 ). (jimmunol.org)
  • Pathogenesis of the condition is explained by injuries to both the alveolar and endothelium epithelium. (tmrresearch.com)
  • The pathogenesis and clinical aspects of bleomycin-induced lung injury will be reviewed here. (uptodate.com)
  • There is considerable experimental and clinical evidence that pro- and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, pneumonia, aspiration, and shock. (nih.gov)
  • Since jnk1 −/− mice were highly resistant to ventilator-induced lung injury, we performed comprehensive gene expression profiling of ventilated wild-type or jnk1 −/− mice to identify novel candidate genes which may play critical roles in the pathogenesis of ventilator-induced lung injury. (plos.org)
  • In the lung, such inflammatory damage is believed to contribute to the pathogenesis of diverse lung diseases, including acute lung injury and the acute respiratory distress syndrome, chronic obstructive lung disease, and cystic fibrosis. (nih.gov)
  • Purpose of review The present review evaluates the evidence available in the literature tracking perioperative mortality and morbidity as well as the pathogenesis and management of acute lung injury (ALI) in patients undergoing thoracotomy. (lww.com)
  • Despite its importance in various organ injuries and cancer, 2 , 3 the role of EVs in the pathogenesis of acute lung injury (ALI) is still largely unexplored. (bmj.com)
  • Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. (jimmunol.org)
  • Mechanisms of Chronic Lung Injury and Fibrosis. (routledge.com)
  • Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterised by progressive deterioration in lung function ultimately leading to death. (ersjournals.com)
  • Additionally, it attenuated the radiation-induced AM polarization and reduced the pneumonitis and fibrosis markers in lung tissues. (unboundmedicine.com)
  • Radiation-induced lung injury, including radiation pneumonitis and radiation fibrosis, is common among patients who have received radiation therapy, and it is the most common treatment-limiting toxicity among patients who receive thoracic radiation. (renalandurologynews.com)
  • Late radiation-induced lung injury typically presents as pulmonary fibrosis. (renalandurologynews.com)
  • In addition, several retrospective clinical studies report that the use of PPIs is associated with beneficial outcomes in chronic lung diseases including idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). (frontiersin.org)
  • We found that therapeutic administration of esomeprazole significantly inhibited the progression of fibrosis throughout the lungs of the animals in this group compared to controls. (frontiersin.org)
  • Professor Danny McAuley from the Centre for Infection and Immunity, a partner in developing the new nanomedicine, added: "This funding allows us to evaluate a completely novel therapeutic approach to the treatment of ALI and if successful, this nanomedicine could also have application in other common lung disorders such as COPD and Cystic Fibrosis. (fiercepharma.com)
  • Nanowerk News ) A new study from North Carolina State University and the National Institute of Environmental Health Sciences (NIEHS) finds that coating multiwalled carbon nanotubes (CNTs) with aluminum oxide reduces the risk of lung scarring, or pulmonary fibrosis, in mice. (nanowerk.com)
  • What are the mechanisms underlying vaping-induced lung injury? (jci.org)
  • Mechanisms underlying lung injury in EVALI. (jci.org)
  • However, the mechanisms by which the bacteria adhere to, then stabilize on, mucosal surfaces before causing injury remain unclear. (jci.org)
  • Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. (routledge.com)
  • We used genome-wide analysis of chromatin accessibility and gene expression following acute lung injury to elucidate repair mechanisms. (nature.com)
  • Finally oxygen toxicity contributes to ventilator-associated lung injury through several mechanisms including oxidative stress. (wikipedia.org)
  • We characterize the role of p38 mitogen-activated protein kinase/mitogen activated protein kinase kinase-3 and c-Jun-NH 2 -terminal kinase-1 in ventilator-induced lung injury and investigate novel independent mechanisms contributing to lung injury during mechanical ventilation. (plos.org)
  • Animal models have been used extensively to model ventilator-induced lung injury (VILI) yet the underlying mechanisms remain incompletely understood. (plos.org)
  • Summary Knowledge of the perioperative risk factors of major complications and understanding of the mechanisms of postthoracotomy ALI enable anesthesiologists to implement 'protective' lung strategies including the use of low tidal volume ( V T ) with recruitment maneuvers, a goal-directed fluid approach and prophylactic treatment with inhaled β 2 -adrenergic agonists. (lww.com)
  • They write, "When we cocultured alveolar epithelium with MSCs, these injury mechanisms were prevented or reduced. (medicalxpress.com)
  • This led them to attempt treating mice infected with H5N1, which resulted in a "clinically significant reduction in lung pathology and increased survival in association with a modulation of these pathogenic mechanisms in vivo. (medicalxpress.com)
  • To identify pathogenic mechanisms and potential adjunctive therapeutic options, we compared the extent to which avian influenza A/H5N1 virus and seasonal influenza A/H1N1 virus impair alveolar fluid clearance and protein permeability in an in vitro model of acute lung injury, defined the role of virus-induced soluble mediators in these injury effects, and demonstrated that the effects are prevented or reduced by bone marrow-derived multipotent mesenchymal stromal cells. (medicalxpress.com)
  • To investigate the molecular mechanisms of acute lung injury (ALI), 3 which is a major problem in humans, various experimental models of ALI have been used, the most common being the endotoxin (bacterial LPS) model. (jimmunol.org)
  • A comprehensive monograph covering in 23 chapters the structural and functional (normal and pharmacologic) foundations for study of chemical and cellular injury to the lung and the mechanisms for injury and their modulation. (annals.org)
  • Phillips, 1988] Blast injury can be categorized as primary, secondary, tertiary, quaternary and quinernary, corresponding to different aspects of the blast loading and injury mechanisms. (uwaterloo.ca)
  • One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of neutrophils into the lung interstitium and alveolar space. (hindawi.com)
  • Interestingly, this protective ventilatory strategy was associated with a marked reduction in the number of neutrophils and the concentration of pro-inflammatory cytokines released into the airspaces of the injured lung. (nih.gov)
  • Moreover, isolated lung polymorphonuclear neutrophils migrate to BALf obtained from gp91 phox-/y mice, further providing evidence of a cell-specific anti-inflammatory role for Nox2 in alveolar macrophages. (springer.com)
  • LysM-Cre/Foxm1(-/-) mice, in which Foxm1 was deleted from myeloid-derived inflammatory cells, including macrophages, monocytes, and neutrophils, were exposed to neonatal hyperoxia, causing lung injury and remodeling. (sigmaaldrich.com)
  • When instilled intratracheally in naive mice, MVs isolated from macrophages primed with LPS induced ALI with an increase in influx of neutrophils and cytokines/chemokines (eg, KC), in lung protein permeability and in the expression of ICAM-1 on alveolar epithelial type I and II cells (Figure 8). (bmj.com)
  • In rat lungs undergoing injury during deposition of IgG immune complexes, the instillation of sICAM-1 significantly enhanced lung injury in a manner associated with enhanced recruitment of neutrophils and increased lung levels of TNF-α and MIP-2. (jimmunol.org)
  • In experimental ALI, the lung parenchyma is damaged by the generation and release of proteases and reactive oxygen and nitrogen species produced by activated lung macrophages and transmigrated neutrophils in the interstitial and alveolar compartments. (jimmunol.org)
  • Antagonism of CXCR2 receptors, predominately located on neutrophils and critical for their immunomodulatory activity, is an attractive pharmacological therapeutic approach aimed at reducing the potentially damaging effects of heightened neutrophil influx into the lung. (frontiersin.org)
  • In this study, we have demonstrated that alveolar macrophages stimulated by bleomycin-induced injury secrete large quantities of biologically active TGF-beta 1 when explanted into tissue culture. (uptodate.com)
  • High doses of the corticosteroid methylprednisolone given intramuscularly before and concomitantly with bleomycin administration prevented the influx of alveolar macrophages into the lungs, diminishing both the number of macrophages present in the alveoli and the total lung content of TGF-beta. (uptodate.com)
  • The findings in this study demonstrate that during bleomycin-induced injury, alveolar macrophages not only secrete large quantities of active TGF-beta 1, but are a predominant source of the enhanced TGF-beta response seen in this model. (uptodate.com)
  • Increased Foxm1 expression was observed in pulmonary macrophages of hyperoxia-exposed mice and in lung tissue from patients with BPD. (sigmaaldrich.com)
  • After hyperoxia, deletion of Foxm1 from the myeloid cell lineage decreased numbers of interstitial macrophages (CD45(+)CD11b(+)Ly6C(-)Ly6G(-)F4/80(+)CD68(-)) and impaired alveologenesis and lung function. (sigmaaldrich.com)
  • Clinicians at the University of Utah also found the same type of cells, known as lipid-laden macrophages, in the lungs of six patients. (denverpost.com)
  • In the current study we investigated the ability of rat sICAM-1 to activate alveolar macrophages and to enhance lung injury. (jimmunol.org)
  • As a so-called pathogen-associated molecular pattern, LPS is recognized by TLR4, which is up-regulated on bronchial epithelial cells and lung macrophages during LPS-induced ALI and is considered to play a crucial role in innate immune responses ( 14 , 15 ). (jimmunol.org)
  • Mice that lacked natural killer T cells had increased amounts of monocytes in the lungs, and severe lung injury similar to those seen in Spanish flu and lethal swine flu. (medindia.net)
  • The researchers tested their hypothesis by genetically engineering mice to lack RAGE and then inducing brain injuries in these rodents as well as in a group of otherwise healthy mice. (acs.org)
  • Using a murine model of SIRS, we examined whole-lung digests and bronchoalveolar lavage fluid (BALf) from WT and gp91 phox-/y mice. (springer.com)
  • Both genotypes demonstrated neutrophil sequestration in the lung during SIRS, but neutrophil migration into the alveolar space was only present in the gp91 phox-/y mice. (springer.com)
  • Macrophage inflammatory protein (MIP)-1α gene expression and protein secretion were higher in whole-lung digest from uninjected gp91 phox-/y mice compared to the WT mice. (springer.com)
  • 2010. NADPH oxidase limits innate immune responses in the lungs in mice. (springer.com)
  • Washington, Oct 29 (ANI): A new study in mice, conducted by researchers at the University of Illinois at Chicago College of Medicine, has shown that adult stem cells from bone marrow can help treat acute lung injury. (thaindian.com)
  • When mice that had been injected with a compound that causes ALI were injected with the purified and cultured Flk and CD34 stem cells, the progenitor cells were able to repair the lung injury, prevent fluid build-up, and led to improved survival. (thaindian.com)
  • They tested the extract on mice that were given toxic bacterial lipopolysaccharides to simulate acute lung injury. (naturalnews.com)
  • Upon analyzing bronchoalveolar lavage fluid from the right lung of the mice, the researchers found that pre-treated mice showed far fewer cells and proteins than untreated mice. (naturalnews.com)
  • C57/BL6 wild-type mice and mice genetically deleted for mitogen-activated protein kinase kinase-3 ( mkk-3 −/− ) or c-Jun-NH 2 -terminal kinase-1 ( jnk1 −/− ) were ventilated, and lung injury parameters were assessed. (plos.org)
  • We demonstrate that mkk3 −/− or jnk1 −/− mice displayed significantly reduced inflammatory lung injury and apoptosis relative to wild-type mice. (plos.org)
  • Functional characterization of MMP8 revealed that mmp8 −/− mice were sensitized to ventilator-induced lung injury with increased lung vascular permeability. (plos.org)
  • Immunohistochemistry and RNA analysis were used to assess Foxm1 in lung tissue from hyperoxia-treated mice and patients with BPD. (sigmaaldrich.com)
  • Results Adrenomedullin dramatically reduced lung permeability in VILI in mice, leading to improved oxygenation. (bmj.com)
  • Adrenomedullin treatment reduced myosin light chain phosphorylation, attenuated the accumulation of leucocytes in the lung and prevented the increase in lactate and creatinine levels in mice ventilated with high tidal volumes. (bmj.com)
  • A researcher at the School of Medicine and his colleagues have succeeded in isolating mouse lung stem cells, growing them in large volumes and incorporating them into injured lung tissue in mice. (stanford.edu)
  • The results demonstrated that 2ME2 improved the survival, lung functions and histopathological parameters of irradiated mice. (unboundmedicine.com)
  • All experiments had appropriate controls such as MVs isolated from the BALF from mice without injury or the supernatant from the washing steps during the isolation of the MVs as well as low and high doses of LPS to ensure the inflammatory response was specific to the MVs, not contaminants. (bmj.com)
  • Adult mice that lacked one Foxf1 allele in lung endothelial cells were more likely to develop pulmonary edema and die after acute lung injury, outcomes that were reversed by administration of S1P. (sciencemag.org)
  • Deletion of a single Foxf1 allele made heterozygous Pdgfb-iCreER/Foxf1 +/− mice more susceptible to acute lung injury. (sciencemag.org)
  • Pharmacological administration of S1P to injured Pdgfb-iCreER/Foxf1 +/− mice restored endothelial barrier function, decreased lung edema, and improved survival. (sciencemag.org)
  • In addition, studies show that the lungs of mice exposed to diacetyl vapors show similar damage to that of bronchiolitis obliterans in humans. (damfirm.com)
  • An international group of researchers recently published the results of a study in the Proceedings of the National Academy of Sciences that treated H5N1-infected mice with multipotent mesenchymal stromal cells (MSCs), which significantly reduced the impairment of fluid clearance from the alveoli and prevented or reduced acute lung injury . (medicalxpress.com)
  • We used CXCR2 −/− deficient/mutant (knock-out, KO) mice, and assessed the changes in critical lung inflammatory NF-κB-driven chemokines released from the parenchyma of CS-exposed mice. (frontiersin.org)
  • Finally, CXCR2 KO mice were protected from lung cells positive for DNA damage response and senescence marker γH2AX. (frontiersin.org)
  • This is also associated with changes in pro-inflammatory chemokines and reduced incursion of γH2AX indicating CXCR2 deficient mice are protected from lung injury. (frontiersin.org)
  • At the core of EVALI and COVID-19 is the clinical syndrome of acute lung injury (ALI), which is defined by injury to both alveolar epithelial cells and pulmonary vascular endothelial cells throughout both lungs. (jci.org)
  • The microaggregates released α-hemolysin toxin, causing localized alveolar injury, as indicated by epithelial dye loss, mitochondrial depolarization, and cytosolic Ca 2+ increase. (jci.org)
  • Alveolar epithelial regeneration is essential for recovery from devastating lung diseases. (nature.com)
  • Although the relative contribution of each pool of progenitors to alveolar epithelial regeneration remains to be determined, AT2 cells are indispensable for alveolar epithelial regeneration following sterile lung injury 28 . (nature.com)
  • Furthermore, a subset of Axin2 + AT2 cells called alveolar epithelial progenitor cells (AEPs), marked by Tm4sf1 expression and fibroblast growth factor 7 (FGF7) responsiveness, were shown to contribute to alveolar re-epithelialization following sterile and infectious lung injuries 19 . (nature.com)
  • We examine the responses of the epithelial cells to the itinerant leukocytes and their cytotoxic products and the consequences of this for lung injury and repair. (nih.gov)
  • More importantly, the MVs in the bronchoalveolar fluid (BALF) at 1 hour contained a substantial amount of TNF but low levels of interleukin (IL)-1β and IL-6 and induced a mouse lung epithelial (MLE)-12 cell line to express intercellular adhesion molecule 1 (ICAM-1) and secrete KC, a murine IL-8 homologue, at 4 hours. (bmj.com)
  • The H5N1 and H7N9 viruses target lung epithelial cells-this is the gas exchange interface where oxygen becomes available to the blood supply. (medicalxpress.com)
  • Vitamin E acetate was identified in bronchoalveolar lavage (BAL) fluid samples (fluid samples collected from the lungs) from 48 of the 51 EVALI patients, but not in the BAL fluid from the healthy comparison group. (cdc.gov)
  • Acute lung injury, a common condition characterized by acute severe hypoxia without evidence of hydrostatic pulmonary edema, remains a key source of mortality and morbidity in critically ill patients. (tmrresearch.com)
  • Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. (tmrresearch.com)
  • It has been observed that even in patients who survive acute lung injury, the quality of life is adversely affected in the long term. (tmrresearch.com)
  • The hydrostatic pressure however remains unaffected in the patients suffering with acute lung injury (ALI). (tmrresearch.com)
  • A general approach to immunocompromised patients with respiratory symptoms and the evaluation of interstitial lung disease in patients receiving chemotherapy are presented separately. (uptodate.com)
  • Among patients identified to date, pulmonary findings on auscultation exam have often been unremarkable, even among patients with severe lung injury (personal communication, Lung Injury Response Clinical Working Group, October 2, 2019). (medscape.com)
  • [ 2 ] however, the predominant use of prefilled THC-containing cartridges among patients with lung injury associated with e-cigarette use suggests that they play an important role. (medscape.com)
  • Patients were classified as having confirmed or probable cases of lung injury associated with e-cigarette use according to CDC's interim outbreak case definitions. (medscape.com)
  • Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. (nih.gov)
  • A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients with ALI. (nih.gov)
  • Studies of HPA axis activation and the role of relative adrenal insufficiency on the outcome of patients with acute lung injury are needed. (biomedsearch.com)
  • But the ages of those impacted by lung injury tend to be younger, with a median age of 24 and nearly 4 in 5 patients under 35. (wral.com)
  • The purpose of this study is to evaluate the efficacy and effect of ulinastatin in inhalation lung injury patients. (clinicaltrials.gov)
  • Results from the largest controlled clinical trial of fluid management methods in patients with severe lung injury provide important new information on the risks and benefits of patient care strategies currently used in the intensive care unit. (innovations-report.com)
  • The two studies that comprised the trial showed that for patients with acute lung injury or its more severe form, acute respiratory distress syndrome, less fluid is better than more, and a shorter, less invasive catheter is as helpful as and safer than a longer catheter for monitoring patients. (innovations-report.com)
  • We now have answers to two important questions to help guide critical care specialists on the best ways to support patients with severe lung injury. (innovations-report.com)
  • However, compared to the liberal fluid management approach, the conservative fluid strategy improved lung function and shortened the time that patients needed mechanical ventilation and intensive care, without increasing the risk of organ failure, the researchers report. (innovations-report.com)
  • A conservative fluid approach limits the amount of fluids patients are given in an attempt to decrease the amount of fluid in the lungs. (innovations-report.com)
  • Caloric restriction failed to improve outcomes in ventilator-dependent patients with acute lung injury compared with full enteral feeding. (medpagetoday.com)
  • HOUSTON -- Caloric restriction failed to improve outcomes in ventilator-dependent patients with acute lung injury, results of an NIH-sponsored, multicenter trial showed. (medpagetoday.com)
  • Investigators in the study compared two feeding strategies for patients with acute lung injury and whose physicians planned to initiate enteral feeding. (medpagetoday.com)
  • Researchers in the Mayor Clinic study reviewed lung biopsies of 17 patients with suspected vape-related injuries and determined that none of the cases showed evidence of the rare form of pneumonia brought on from lipid accumulation (fatty substances such as oils) that some have attributed as the cause. (bostonherald.com)
  • U.S. District Judge Harvey Bartle III rejected Pfizer's arguments that no reliable evidence existed to confirm that the deadly diet pills could lead to an often-fatal lung disease that struck patients years after the pills were stopped. (newsinferno.com)
  • One-third of all patients in intensive care units worldwide receive MV. 1 However, even minimal MV-induced physical forces on lung tissue may evoke ventilator-induced lung injury (VILI), an important undesirable effect of respirator treatment. (bmj.com)
  • CHICAGO - Tests of lung samples taken from 29 patients with vaping-related lung injuries suggest all contained Vitamin E acetate, a discovery U.S. officials described as a "breakthrough" in the investigation of the nationwide outbreak that topped 2,000 cases this week. (nationalpost.com)
  • The substance has also been identified in tests by U.S. and state officials of product samples collected from patients with the vaping injury. (nationalpost.com)
  • Although the substance was detected in all 29 of the lung samples, which came from patients in several different states, more testing is needed to establish a causal link between exposure and injury, Schuchet said, adding that "many substances are still under investigation. (nationalpost.com)
  • Nearly 85 percent of lung injury patients in the nationwide outbreak have reported using products containing THC. (nationalpost.com)
  • In the CDC analysis, THC was detected in 23 of 28 patient samples of lung cells, including from three patients who said they did not use THC products. (nationalpost.com)
  • The vaping injury patients also had a higher rate of using "Dank Vapes," a class of largely counterfeit THC-containing products, according to the study. (nationalpost.com)
  • Recent findings Over the last decade, despite increasing age and comorbid conditions, the operative mortality has remained unchanged for patients undergoing lung resection, whereas procedure-related complications have declined. (lww.com)
  • The mystery over the exact cause deepened this week with a letter published Wednesday in the New England Journal of Medicine by pathologists from the Mayo Clinic who studied lung biopsies from 17 patients in the outbreak. (denverpost.com)
  • Researchers found none of the patients had evidence of lipoid pneumonia, a rare form of pneumonia typically associated with elderly people accidentally inhaling oils into their lungs. (denverpost.com)
  • The severity of lung injury varies widely among patients, ranging from asymptomatic to severe respiratory failure and death. (renalandurologynews.com)
  • Organizing pneumonia is also more commonly seen outside of the radiation field than traditional radiation pneumonitis, often in the contralateral lung, and is more common among patients who have received radiation for breast cancer. (renalandurologynews.com)
  • A more rare form of radiation-induced lung injury, referred to as radiation recall, can be seen in patients who receive chemotherapy after undergoing previous thoracic radiation, often years prior to the development of pneumonitis. (renalandurologynews.com)
  • On physical examination, the patient may have normal lung sounds, but patients occasionally have rales or a slight rub. (renalandurologynews.com)
  • FOXF1 abundance was decreased in pulmonary endothelial cells of human patients with acute lung injury. (sciencemag.org)
  • Vitamin E acetate appears to be a common link among the products containing THC used by patients with electronic cigarette- or vaping-associated lung injury, or EVALI, in Minnesota, according to a report published in Morbidity and Mortality Weekly Report . (healio.com)
  • Researchers at Queen's University Belfast have devised a 'magic bullet' nanomedicine which could become the first effective treatment for Acute Lung Injury or ALI, a condition affecting 20 per cent of all patients in intensive care. (fiercepharma.com)
  • ALI patients can become critically ill and develop problems with breathing when their lungs become inflamed and fill with fluid. (fiercepharma.com)
  • Montevideo have over thirty years of experience helping lung and respiratory injury patients win their case in a court of law and be awarded the maximum possible compensation. (damfirm.com)
  • Temporal Changes in Ventilator Settings in Patients With Uninjured Lungs: A Systematic Review. (harvard.edu)
  • The amount of patients experiencing probable lung injury related to e-cigarette usage has jumped to over a million, US health authorities said Thursday, although the death toll from the epidemic currently stands at 18. (keyc.tv)
  • A report from clinicians at North Carolina last month imputed to the inhalation of fatty compounds out of aerosolized oils as causing severe lipoid pneumonia, but a new study from the Mayo Clinic released this week found patients' lungs were subjected to noxious fumes. (keyc.tv)
  • healthy and patients with acute lung injury. (bioportfolio.com)
  • During artificial ventilation the cyclic opening and closing of alveoli during artificial ventilation results in patients with acute lung injury (ALI) in a higher mortality. (bioportfolio.com)
  • Finding the best level of PEEP in patients with injured lungs to avoid atelectasis and alveolar strain induced by inadequately high or low PEEP levels is a challenge. (bioportfolio.com)
  • The purpose of this study is to develop a protocol for measuring regional opening and closing pressures using the method of electrical impedance tomography in lung healthy and ALI patients. (bioportfolio.com)
  • Spinal cord blood flow in patients with acute spinal cord injuries. (bioportfolio.com)
  • Phase I-II Clinical Trial - Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with Acute Lung Injury ,open label, controlled prospective study. (clinicaltrials.gov)
  • The number of Segway injuries is only a small fraction considering its emergency department receives about 49,000 to 63,000 adult patients annually. (cnn.com)
  • Ten of the 41 patients (24.4 percent) were admitted to the emergency department and four of them had to stay in the Intensive Care Unit for traumatic brain injuries. (cnn.com)
  • In patients with popcorn lung, it's irreversible. (nugget.ca)
  • As the outbreak of electronic cigarette- or vaping-associated lung injuries, or EVALI, continues, CDC has updated its interim guidance to help clinicians diagnose and treat patients with the condition in light of the approaching 2019-2020 influenza season. (healio.com)
  • Four out of 10 septic patients develop lung injury. (healthcanal.com)
  • In July 2019, the Illinois Department of Public Health and the Wisconsin Department of Health Services launched a coordinated epidemiologic investigation after receiving reports of several cases of lung injury in previously healthy persons who reported electronic cigarette (e-cigarette) use, or vaping. (medscape.com)
  • During July-September 2019, possible cases of lung injury associated with e-cigarette use in Illinois and Wisconsin were investigated to determine symptoms, exposures, and medical care history related to the outbreak. (medscape.com)
  • FRIDAY, Aug. 30, 2019 (HealthDay News) -- The number of people who've developed a severe form of lung disease potentially tied to vaping has now risen to 215 cases across 25 states, and federal health officials are recommending that Americans not use e-cigarettes. (webmd.com)
  • In 2019, e-cigarette or vaping product use-associated lung injury (EVALI) was recognized as a unique disease entity, and rapid escalation of the numbers of those affected was such that it has been labeled a public health crisis, with over 2800 cases of hospitalizations and 68 deaths as of March 2020. (jci.org)
  • November 22, 2019 -- As the vaping epidemic continues to unfold, a new case study centered on a previously healthy 17-year-old male has revealed yet another clinical indication of vaping-associated lung injury evident on CT scans. (auntminnie.com)
  • In the United States in 2019, there was an outbreak of electronic cigarette, or vaping, product use-associated lung injury (EVALI). (aappublications.org)
  • Most of the initial lawsuits in the mass litigation were filed before reports of widespread vaping-related lung injuries and deaths began cropping up in mid-2019. (drugwatch.com)
  • The latter half of 2019 saw the identification of an entirely new respiratory illness and introduction of a new diagnosis- e-cigarette, or vaping, product use associated lung injury (EVALI)-into the medical lexicon. (arrs.org)
  • A TrkB agonist improved outcomes in vivo following lung injury. (nature.com)
  • 2005. Incidence and outcomes of acute lung injury. (springer.com)
  • The mortality rates was 8% in each group, and there were no significant differences in any of the other secondary endpoints of time to recovery from lung injury, days free of organ failure, functional outcomes, or sedative use. (medpagetoday.com)
  • It has been suggested that obesity may affect the outcomes of critical illness, but few trials have focused on acute lung injury specifically. (rtmagazine.com)
  • Needham and colleagues present much needed data regarding long term hard outcomes in this day and age of acute lung injury (ALI) management (1) which reflects 'effectiveness' rather than 'efficacy' (2) of lung protective mechanical ventilation. (bmj.com)
  • Other contributory factors which are likely to lead to acute lung injury comprise pneumonia, sepsis, major trauma, and inhalation of noxious fumes. (tmrresearch.com)
  • The triggering injury can be a critical infection like sepsis (blood infection), pneumonia, chest trauma, smoke inhalation, sickle cell anemia or a reaction to medicines. (sun-sentinel.com)
  • This JCI Viewpoint article discusses these potential mechanistic pathways in the context of how other lung inhalation injuries occur and pinpoints important research needs moving forward. (jci.org)
  • Silicosis is a lung disease caused by inhalation of crystalline free silica dust. (medindia.net)
  • There is increasing evidence that inhalation of black carbon particles is associated with a wide range of health effects - including heart attacks and reduced lung function. (eurekalert.org)
  • Several factors are important in determining the location and magnitude of toxic lung injury that arises from inhalation of smoke, aerosols, vapors, or fumes, including the size and water solubility of the inhaled material. (oncologynurseadvisor.com)
  • Several important determinants shape the clinical presentation of toxic inhalation injury, including where the toxin is deposited in the respiratory system. (oncologynurseadvisor.com)
  • The first worker suffers injuries due to inhalation of toxic substances. (pritzkerlaw.com)
  • Smoke inhalation injuries can cause respiratory failure. (pritzkerlaw.com)
  • Demling, Robert H. "Smoke inhalation lung injury: an update. (pritzkerlaw.com)
  • CDC, the U.S. Food and Drug Administration (FDA), state and local health departments, and other clinical and public health partners are continuing to monitor e-cigarette, or vaping, product use-associated lung injury (EVALI). (cdc.gov)
  • The FP-1201-lyo treatment for acute lung injury is now in the 3rd phase of clinical trials and is anticipated to obtain European marketing authorization in the near future. (tmrresearch.com)
  • As such recombinant soluble ACE2 is currently being tested in phase 2 clinical trials as a potential therapy for the treatment of acute lung injury in humans 18 , 19 . (nature.com)
  • The trial was conducted by scientists from the Acute Respiratory Distress Syndrome Clinical Research Network of the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. (innovations-report.com)
  • Acute lung injury (ALI) is a clinical condition where lung tissue is deprived of oxygen by conditions not involving hypertension in the left atrium. (naturalnews.com)
  • Understand that this study shows that putting children with acute lung injury in the prone position during the acute phase does not appear to offer a clinical benefit over placing children in the customary supine position. (medpagetoday.com)
  • The purpose of this prospective, randomized clinical trial is to understand and measure lung injuries caused by CPB in aortic valve surgery. (clinicaltrials.gov)
  • Ventilator-associated lung injury arises as a clinical complication of mechanical ventilation. (plos.org)
  • This paradigm has important clinical implications because of the potential for selective blockade of these pathways to prevent or attenuate lung injury. (nih.gov)
  • Radiographic findings of lung injury are more much common than clinical symptoms of radiation-induced lung injury, and frequently occur in the area of the lung exposed to radiation. (renalandurologynews.com)
  • Based on these preclinical and clinical observations, we hypothesized that PPIs ameliorate smoke-induced lung injury. (frontiersin.org)
  • In fact, the results of this mouse trial were so remarkable that the authors wrote, "This potential adjunctive therapy for severe influenza-induced lung disease warrants rapid clinical investigation. (medicalxpress.com)
  • How Well Do Clinical and Lung Tissue Criteria for the Acute Respiratory Distress Syndrome Match? (annals.org)
  • The CDC, US Food and Drug Administration, state and local health departments, and other clinical and public health partners are continuing to investigate the multi-state outbreak of lung injury associated with using e-cigarette products. (fox2now.com)
  • Inflammatory Cells and Mediators in Acute Lung Injury. (routledge.com)
  • This review develops the thesis that BPD in VLBW infants results from inflammatory mediators interfering with the signaling required for normal late gestational lung development. (nih.gov)
  • Proinflammatory mediators may be elevated because of fetal exposure, postnatal infection or by release from preterm lungs ventilated at either low or high lung volumes. (nih.gov)
  • Biotrauma involves the lung suffering injury from any mediators of the inflammatory response or from bacteremia. (wikipedia.org)
  • While these tasks are usually performed without injury to host tissues, in pathologic circumstances such as sepsis, potent antimicrobial compounds can be released extracellularly, inducing a spectrum of responses in host cells ranging from activation to injury and death. (nih.gov)
  • The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by disturbances in the pulmonary microcirculation is poorly understood. (ersjournals.com)
  • This study aimed to investigate how the pulmonary microcirculation is distorted in sepsis-induced acute lung injury (ALI) and reveal the underlying cellular pathophysiologic mechanism. (ersjournals.com)
  • Using a custom-made intravital lung microscopic imaging system in a murine model of sepsis-induced ALI, we achieved direct real-time visualisation of the pulmonary microcirculation and circulating cells in vivo . (ersjournals.com)
  • We are looking to test vitamin C as an intervention for early lung injury due to sepsis. (healthcanal.com)
  • In the current study, we report that ACE2 could mediate the severe acute lung injury induced by influenza A (H7N9) virus infection in an experimental mouse model. (nature.com)
  • In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats. (nih.gov)
  • Because beta-2 agonists have been shown to reduce permeability induced lung injury, it is anticipated that the severity of lung injury will be reduced by aerosolized beta-2 agonist therapy. (clinicaltrials.gov)
  • FOXF1 knockdown in vitro and in vivo disrupted adherens junctions, enhanced lung endothelial permeability, and increased the abundance of the mRNA and protein for sphingosine 1-phosphate receptor 1 (S1PR1), a key regulator of endothelial barrier function. (sciencemag.org)
  • In contrast, the non-IL-2-infused sheep ( n = 3) recruitment of the lung vasculature by left atrial balloon inflation led to a rise in Q̇L from 2.4 to 8.2 ml/30 min, whereas the L/P ratio declined from 0.62 to 0.25, suggesting that the protein-rich lymph flow after IL-2 administration reflected increased microvascular permeability. (aacrjournals.org)
  • An integrated understanding of these biological processes is essential for developing therapeutics for devastating human lung diseases that injure alveolar epithelium 15 . (nature.com)
  • Pneumoconiosis is a group of lung diseases caused by inhaled dust particles. (medindia.net)
  • The work raises hopes for regenerative therapies that could heal currently intractable lung diseases. (stanford.edu)
  • For many people with end-stage lung diseases, the only option is lung transplantation. (stanford.edu)
  • Overall, our work extends the emerging anti-inflammatory and antifibrotic potential of PPIs and their role in modulation of chronic lung diseases. (frontiersin.org)
  • The mechanism of bleomycin-induced lung injury is not entirely clear, but likely includes components of oxidative damage, relative deficiency of the deactivating enzyme bleomycin hydrolase, genetic susceptibility, and elaboration of inflammatory cytokines. (uptodate.com)
  • An understanding of what causes cytokine release and how cytokines influence lung development is necessary to develop targeted therapies to minimize BPD. (nih.gov)
  • Both of these cytokines are known to play a role in IgG immune complex-mediated lung injury ( 12 , 13 ). (jimmunol.org)
  • An injury to the lungs causes lung air sacs (alveoli) to fill with fluid. (sun-sentinel.com)
  • Possible reasons for predisposition to VALI include: An injured lung may be at risk for further injury Cyclic atelectasis is particularly common in an injured lung Overdistension of alveoli and cyclic atelectasis (atelectotrauma) are the primary causes for alveolar injury during positive pressure mechanical ventilation. (wikipedia.org)
  • Severe injury to alveoli causes swelling of the tissues (edema) in the lungs, bleeding of the alveoli, loss of surfactant (decrease in lung compliance) and complete alveoli collapse (biotrauma). (wikipedia.org)
  • Loh and his colleagues searched for and found a single lung stem cell that could create cells in both the airway and the alveoli. (stanford.edu)
  • The preterm lung is highly susceptible to injury during resuscitation or more chronic mechanical ventilation because the gas volumes/kg body weight of the lungs are small. (nih.gov)
  • Ventilator-associated lung injury (VALI) is an acute lung injury that develops during mechanical ventilation and is termed ventilator-induced lung injury (VILI) if it can be proven that the mechanical ventilation caused the acute lung injury. (wikipedia.org)
  • citation needed] During mechanical ventilation, the flow of gas into the lung will take the path of least resistance. (wikipedia.org)
  • Mechanical ventilation causes ventilator-induced lung injury in animals and humans. (plos.org)
  • Recruitment manoeuvres, consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in lung protective ventilation strategies t. (bioportfolio.com)
  • Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in adults without acute lung injury. (bioportfolio.com)
  • Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. (innovations-report.com)
  • Adaptive Support Ventilation Attenuates Ventilator Induced Lung Injury: Human and Animal Study. (harvard.edu)
  • Acute lung injury is a part of the systemic inflammatory process where the lung demonstrates symptoms similar to other tissues such as extravascation of protein rich fluid, destruction in capillary endothelium, and interstitial edema. (tmrresearch.com)
  • Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine production. (lifeboat.com)
  • Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion. (nih.gov)
  • A reduction in the severity of lung injury and the quantity of alveolar edema should result in earlier extubation and more ventilator free days, improved pulmonary oxygen uptake, and improved lung compliance. (clinicaltrials.gov)
  • Vitamin E acetate has been found in product samples tested by FDA and state laboratories and in patient lung fluid samples tested by CDC from geographically diverse states. (cdc.gov)
  • Vitamin E acetate has not been found in the lung fluid of people that do not have EVALI. (cdc.gov)
  • Recent data have highlighted the role of extravascular lung water in response to treatment to guide fluid therapy and ventilator strategies. (hindawi.com)
  • Pulmonary oedema refers to the accumulation of fluid within the extravascular space of the lung and occurs when the Starling forces are unbalanced. (hindawi.com)
  • Others get rid of the fluid but enter a third phase where there is deposition of scar tissue in the lungs. (sun-sentinel.com)
  • Fluid builds up in the lungs, and as a result, breathing is difficult, and other organs such as kidneys, liver, heart or brain fail if they do not get enough oxygen from the blood. (innovations-report.com)
  • The amount of fluid in the body must be carefully monitored and adjusted to maximize lung and heart function. (innovations-report.com)
  • Doctors ordered a chest x-ray which showed that the patient had excess fluid that had accumulated in the left pleural cavity, the fluid-filled space that surrounds the lungs. (survivingmesothelioma.com)
  • Uncontrolled, excessive infiltration of leukocytes into the tissue leads to a destruction of organ structure and is a main characteristic of acute and chronic inflammatory disorders like atherosclerosis, reperfusion injury or acute lung injury (ALI) [ 1 ]. (hindawi.com)
  • Infection by Staphylococcus aureus strain USA300 causes tissue injury, multiorgan failure, and high mortality. (jci.org)
  • The results of this study demonstrate that hydrogen-rich saline ameliorated hyperoxia-induced acute lung injury by reducing oxidative stress and inflammatory cascades in lung tissue. (nih.gov)
  • The newly regenerated lung tissue is red, and the type-2 alveolar cells are green. (stanford.edu)
  • Scientists have previously had little success in putting new lung cells into damaged lung to regenerate healthy tissue," Loh said. (stanford.edu)
  • What we saw was that these multipotent stem cells repaired the injured tissue and were able to differentiate into the many different kinds of cells that make up the healthy lung," said Nichane. (stanford.edu)
  • Our newfound ability to grow these mouse multipotent lung stem cells in a petri dish in very large numbers, and the cells' ability to regenerate both lung airway and alveolar tissue, constitutes a first step towards future lung regenerative therapies," Loh said. (stanford.edu)
  • Future work will focus on whether analogous multipotent stem cells can be found and cultivated from humans, which may open the way to eventually replenishing damaged lung tissue in the clinic. (stanford.edu)
  • These agents may produce direct tissue injury in the upper airway, with the magnitude of the injury dependent upon the dosage and duration of exposure. (oncologynurseadvisor.com)
  • Explosion blast waves exert intense pressure on the body, and most often adversely affect the ears, abdomen, and lungs, the tissue of which can be torn or burst. (pritzkerlaw.com)
  • Potential drug interactions that may modify the course of bleomycin-induced lung injury and the therapeutic options available for management will also be discussed. (uptodate.com)
  • The content of pro-inflammatory cytokine interleukin IL-1b and TNF-a in the lung tissues were detected by enzyme-linked immunosorbent assay (ELISA). (nih.gov)
  • The extract prevented changes to the lung tissues and improved the activity of antioxidant enzymes. (naturalnews.com)
  • Development of an effective drug that selectively protects normal lung tissues and sensitizes tumor cells to radiotherapy is an unmet need. (unboundmedicine.com)
  • Lung tissues were used for histopathological examination or immunofluorescence staining for CD68 (pan-macrophage marker), Arginase-1 (Arg1, M2-specific marker), inducible nitric oxide synthase (iNOS, M1-specific marker) and HIF-1α. (unboundmedicine.com)
  • VEGF and γH2AX expression in lung tissues were detected by western blot. (unboundmedicine.com)
  • Foxm1 regulates resolution of hyperoxic lung injury in newborns. (sigmaaldrich.com)
  • Flavored vapor also can contain diacetyl, a chemical linked to a condition called " popcorn lung ," Rizzo noted. (webmd.com)
  • In popcorn lung, the tiny air sacs in the lungs become scarred, resulting in the thickening and narrowing of the airways, the American Lung Association explained. (webmd.com)
  • Some call it "popcorn lung" and the symptoms do not stop when someone ceases to be exposed to it. (damfirm.com)
  • Researchers in Canada have identified a new kind of vaping-related lung injury they believe is linked to flavorings in conventional vape pens, causing symptoms similar to the "popcorn lung" injury seen in workers exposed to flavorings in microwave popcorn. (nugget.ca)
  • Our data demonstrate that Foxm1 influences pulmonary inflammatory responses to hyperoxia, inhibiting neutrophil-derived enzymes and enhancing monocytic responses that limit alveolar injury and remodeling in neonatal lungs. (sigmaaldrich.com)
  • Finally, airway instillation of sICAM-1 intensified lung injury produced by intrapulmonary deposition of IgG immune complexes in a manner associated with enhanced lung production of TNF-α and MIP-2 and increased neutrophil recruitment. (jimmunol.org)
  • In IgG immune complex-induced lung injury in rats, inflammatory injury is neutrophil dependent and requires ICAM-1, CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and E- and L-selectin. (jimmunol.org)
  • LPS-induced ALI was neutrophil-dependent, but it was not associated with generation of C5a in the lung and was independent of C3, C5, or C5a. (jimmunol.org)
  • Camus P. Interstitial lung disease from drugs, biologics, and radiation. (uptodate.com)
  • Most capable study for diagnosis of any diffuse lung disease (i.e., hypersensitivity pneumonitis, interstitial lung disease, etc. (oncologynurseadvisor.com)
  • We speculate that Nox2 represses the development of inflammatory lung injury by modulating chemokine expression by the alveolar macrophage. (springer.com)
  • We demonstrate that mitogen-activated protein kinase pathways mediate inflammatory lung injury during ventilator-induced lung injury. (plos.org)
  • MAPK activation is associated with various forms of inflammatory lung injury. (plos.org)
  • These images are a random sampling from a Bing search on the term "Transfusion-Related Acute Lung Injury. (fpnotebook.com)
  • Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the United States and other countries. (bloodjournal.org)
  • The signs and symptoms associated with electronic cigarette (e-cigarette), or vaping, product use-associated lung injury (EVALI) have only grown since the time of the earliest EVALI reports in June of this year. (auntminnie.com)
  • Collectively, the early reports of EVALI illustrate that e-cigarettes appear to trigger a wide variety of different lung pathologies and illnesses and will continue to pose health risks, Dr. Matthew Stanbrook, PhD, of the University of Toronto wrote in an accompanying editorial. (auntminnie.com)
  • Acute lung injury (ALI) remains an important cause of illness and mortality among the critically ill patient population. (tmrresearch.com)
  • Acute lung injury carries a high burden of morbidity and mortality and is characterised by nonhydrostatic pulmonary oedema. (hindawi.com)
  • The quantification of extravascular lung water may predict mortality and multiorgan dysfunction. (hindawi.com)
  • Acute lung injury (ALI), developing as a component of the systemic inflammatory response syndrome (SIRS), leads to significant morbidity and mortality. (springer.com)
  • Primary blast injury occurring in the lungs is of importance, since lung injury results in one of the highest rate of blast mortality. (uwaterloo.ca)
  • CNN - There were 2,172 cases of lung injury linked to vaping as of November 13, the US Centers for Disease Control and Prevention said on Thursday. (wral.com)
  • Make a difference by delivering research, education and advocacy to those impacted by lung disease. (lung.org)
  • Angiotensin-converting enzyme (ACE) and ACE2 are involved in several pathologies such as cardiovascular functions, renal disease and acute lung injury. (nature.com)
  • Bronchopulmonary dysplasia (BPD)/chronic lung disease occurs primarily in very low birth weight infants (VLBW) often without antecedent severe respiratory distress syndrome. (nih.gov)
  • Confirmed and probable cases of vaping-associated lung illness have risen to 1,080 across 48 states and one U.S. territory, according to the latest numbers from the Centers for Disease Control and Prevention. (wsj.com)
  • The American Vaping Association, a nonprofit that "advocates for sensible regulation of vaping products" places blame for the mystery lung disease squarely on products made for use with illegal drugs. (newsweek.com)
  • Claims over the fatal fen-phen lung disease have generated verdicts and settlements in the tens of millions of dollars. (newsinferno.com)
  • Describe the advantages and disadvantages of this technique for diagnosis of toxic lung injury (Silo-Filler's disease). (oncologynurseadvisor.com)
  • V. Describe the advantages and disadvantages of the alternative techniques for diagnosis of toxic lung injury (Silo-Filler's disease). (oncologynurseadvisor.com)
  • They hope their discovery could lead to better therapies for people with lung disease. (stanford.edu)
  • For more information on the vaping-related lung injury outbreak visit https://health.utah.gov/lung-disease-investigation . (utah.gov)
  • Lung disease, potentially tied to vaping, has prompted the US Centers for Disease Control and Prevention to advise against the use of e-cigarettes. (health24.com)
  • E-cigarettes can cause serious lung disease. (health24.com)
  • The researchers followed the workers for years to see how many of them developed mesothelioma or a chronic lung disease called asbestosis. (survivingmesothelioma.com)
  • Hundreds more Americans have been sickened by a mysterious vaping-related lung disease, and the death toll has risen to 18, according to federal health data released Thursday. (denverpost.com)
  • Officials have said they suspect the cause of the lung disease to be some kind of chemical exposure but have not identified a single e-cigarette or vaping product, brand or specific substance that has been definitively linked to the growing national outbreak. (denverpost.com)
  • Food processing employees may be at risk of developing severe lung disease, respiratory injuries, or being afflicted by asthma due to the "natural" butter flavoring diacetyl. (damfirm.com)
  • It is a severe form of obstructive lung disease which occurs when small airways become inflamed and scarred, resulting in the thickening and narrowing of the airways. (damfirm.com)
  • Juul and other e-cigarette lawsuits claim vaping led to seizures, serious lung injuries or disease and strokes. (drugwatch.com)
  • I believe we actually have the feeling now that there might be a great deal of different nasty things in e-cigarette or even vaping goods, and they could lead to unique mishaps from the lung," Anne Schuchat, a senior officer with the Centers for Disease Control and Prevention, said in a telephone with colleagues. (keyc.tv)
  • Hundreds more cases of vaping-related lung injuries across the United States have been reported to the US Centers for Disease Control and Prevention. (fox2now.com)
  • As of December 17, there were 2,506 hospitalized cases of lung injury linked to vaping in the United States, the US Centers for Disease Control and Prevention s. (wqad.com)
  • The study, published in the July 13 issue of the Journal of the American Medical Association, was designed to test the hypothesis that placing children in the prone position during the acute phase of treatment could improve both oxygenation and regional changes in ventilation, thereby decreasing the risk of ventilator-associated lung injury and facilitating recovery. (medpagetoday.com)
  • In contrast, ventilator-associated lung injury (VALI) exists if the cause cannot be proven. (wikipedia.org)
  • Another possible ventilator-associated lung injury is known as biotrauma. (wikipedia.org)
  • Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury. (routledge.com)
  • this book provides a current overview of acute and chronic lung injury….the book's extensive reference lists are a valuable resource for more in-depth information. (routledge.com)
  • This study examines the role of thromboxane (Tx)A 2 in IL-2 induced lung injury in sheep with chronic lung lymph fistulae. (aacrjournals.org)
  • If PMN migration into the lung is impaired, the immune response is severely disturbed [ 5 ]. (hindawi.com)
  • Specifically, the researchers found that immune cells called, "natural killer T cells," may reduce the overwhelming numbers of another type of immune cell, called "inflammatory monocytes," which when present in large numbers, lead to lung injury at the end stage of severe flu infection. (medindia.net)
  • Using highly-sensitive fluorescent antibody technology, this study was one of the first to document the sequential changes in innate immune response in the lungs during severe flu infection. (medindia.net)
  • The Utah clinicians suggested that the presence of these same lipid-containing immune cells could be a marker for vaping-related lung injury. (denverpost.com)
  • Therefore, through engagement of β 2 integrins, sICAM-1 enhances alveolar macrophage production of MIP-2 and TNF-α, the result of which is intensified lung injury after intrapulmonary disposition of immune complexes. (jimmunol.org)
  • For the full development of injury in other experimental ALI models (e.g., intrapulmonary IgG immune complex deposition), local activation of complement is usually required ( 7 ). (jimmunol.org)
  • 12 The normal underlying lung parenchyma still allows for normal gas transfer in obesity. (rtmagazine.com)
  • Given the continuous exposure of the upper and lower airways and lung parenchyma to the environment, the possibility that we may inhale any of a broad array of toxic substances is not surprising. (oncologynurseadvisor.com)
  • Very small particles--such as those smaller than 0.1 µ in diameter, penetrate deeply into the distal airways and lung parenchyma. (oncologynurseadvisor.com)
  • found that, in adult lung endothelial cells, the transcription factor FOXF1 transcriptionally activated a gene encoding the receptor for S1P, a lipid mediator that enhances the barrier function of endothelial cells. (sciencemag.org)
  • The transcription factor FOXF1 activates a signaling pathway in endothelial cells that promotes recovery from lung injury. (sciencemag.org)
  • Extravascular lung water measurement offers information not otherwise available by other methods such as chest radiography, arterial blood gas, and chest auscultation at the bedside. (hindawi.com)
  • Postthoracotomy ALI has become the leading cause of operative death, its incidence has remained stable (2-5%) and earlier diagnosis can be made by assessing the extravascular lung water volume with the single-indicator dilution technique. (lww.com)
  • It includes acute respiratory failure owing to progressive hypoxemia, diffuse bilateral pulmonary infiltration, and reduced lung compliance. (tmrresearch.com)
  • ALI occurs when capillary-alveolar barriers in the lung are disrupted, resulting in a variety of dangerous symptoms that can lead to respiratory failure. (rochester.edu)
  • Acute lung injury (ALI) is induced by a variety of external and internal factors and leads to acute progressive respiratory failure. (bioportfolio.com)
  • Although organizing pneumonia has traditionally been included with the early manifestations of radiation lung injury, it can present later, and last longer, than traditional radiation pneumonitis, although the symptoms are similar. (renalandurologynews.com)
  • Signs and symptoms of a blast lung injury may show up right away, or within a day or two. (pritzkerlaw.com)
  • Symptoms of a pulmonary contusion are similar to blast lung, with the addition of wheezing and low blood pressure (hypotension). (pritzkerlaw.com)
  • The chemical is generally considered harmless in foods, supplements and lotions -- but inhaling it "may interfere with normal lung functioning," according to the CDC. (wral.com)
  • Thus, FOXF1 promotes normal lung homeostasis and repair, in part, by enhancing endothelial barrier function through activation of the S1P/S1PR1 signaling pathway. (sciencemag.org)
  • Potential treatment methods such as statin therapy and nutritional strategies are also expected to gain more focus from research bodies operating in the area of treatment of acute lung injury. (tmrresearch.com)
  • Every patient will maintain their standard treatment of acute lung injury, with maximum tolerated dosage without side effects. (clinicaltrials.gov)
  • Therefore, the aim of the current study was to further determine whether interfering with RAS could influence the severity of avian influenza A (H7N9) virus-induced lung injury in an experimental mouse model. (nature.com)
  • The amount of money we can recover depends on a number of factors, including the severity of the injuries and the facts surrounding the accident. (pritzkerlaw.com)
  • It is not always easy for a person to fully understand the true severity of their injury. (gjel.com)
  • This depends entirely on the severity of the collapsed lung. (gjel.com)
  • When a patient needs a lung transplant, chances are the donated organ will come from a person who suffered traumatic brain injury. (acs.org)
  • As a result, only 15 to 20% of the lungs are viable for transplant. (acs.org)
  • A lung transplant is a possible treatment option for a mesothelioma patient whose respiratory health has deteriorated to a level at which doctors predict that the patient will not live long without a healthy replacement lung. (consumerinjurylawyers.com)
  • However, lung transplant surgery is a major undertaking. (consumerinjurylawyers.com)
  • Consequently, not every mesothelioma patient is healthy enough to survive lung transplant surgery. (consumerinjurylawyers.com)
  • Even when a mesothelioma patient is healthy enough to undergo lung transplant surgery, the patient may not live to see it. (consumerinjurylawyers.com)
  • This is because lung transplant surgery requires an organ donor. (consumerinjurylawyers.com)
  • Unfortunately, it can take several months to find a suitable donor, and this may be too long for a mesothelioma patient who urgently needs a lung transplant to wait. (consumerinjurylawyers.com)
  • Lung transplant surgery may have to be performed with very little notice, such as when a lung donor becomes available following a fatal accident. (consumerinjurylawyers.com)
  • Once a donor is found, the donor's lungs are removed and immediately transported to the facility where the recipient will undergo lung transplant surgery. (consumerinjurylawyers.com)
  • Before the lung transplant surgery, the recipient is placed under general anesthesia. (consumerinjurylawyers.com)
  • During lung transplant surgery, the recipient's heart stops, but a heart-lung bypass machine and an artificial breathing machine are used to maintain the body's stability. (consumerinjurylawyers.com)
  • Following the lung transplant surgery, the patient will spend several days in an intensive care unit for observation. (consumerinjurylawyers.com)
  • If you, or a family member, have been diagnosed with mesothelioma and need a lung transplant, our experienced lawyers can explain you legal rights and options. (consumerinjurylawyers.com)
  • Fearing he might need a lung transplant, the team transferred the teen to a regional transplant center in Toronto. (nugget.ca)
  • Here, we examined potential benefits of glutamine (GLN) on a two-hit model for VILI after acid aspiration-induced lung injury in rats. (lifeboat.com)
  • However, even protective ventilation strategies applying minimal mechanical stress may evoke ventilator-induced lung injury (VILI). (bmj.com)
  • Adjuvant pharmacological strategies in addition to lung-protective ventilation to attenuate VILI are lacking. (bmj.com)
  • 4 However, preinjured lungs in particular are sensitive for the development of VILI even in the setting of lung-protective ventilation. (bmj.com)
  • 6 As the necessity to guarantee sufficient gas exchange frequently limits a further substantial reduction of tidal volumes and oxygen supply, new adjuvant pharmacological treatments in addition to lung-protective ventilation are needed to prevent VILI. (bmj.com)
  • Pulmonary radiation injury most commonly occurs as a result of radiation therapy administered to treat cancer. (wikipedia.org)
  • Radiation-induced lung injury almost always occurs inside the radiation ports. (renalandurologynews.com)
  • Because of the important role of rat ICAM-1 in the development of lung inflammatory injury, soluble recombinant rat ICAM-1 (sICAM-1) was expressed in bacteria, and its biologic activities were evaluated. (jimmunol.org)
  • Although blocking of ICAM-1 in the vasculature or in the distal airway compartment inhibited full development of lung injury, anti-CD11a was only protective when given i.v., and anti-CD11b was only protective when given intratracheally. (jimmunol.org)
  • However, in the LPS-induced model of ALI, it is not clear to what extent activation of the complement system contributes to the development of lung injury, even though LPS is known to be an activator of the complement system via the classical and the alternative pathways ( 11 , 12 , 13 ). (jimmunol.org)
  • The CDC's website also states that if a lung biopsy is obtained, the routine pathology processing, which includes formalin-fixation and paraffin-embedding, "can remove lipids. (denverpost.com)
  • 10 They demonstrated a decrease in total respiratory compliance in obese subjects due to a decrease in both lung and chest wall compliance. (rtmagazine.com)
  • These findings indicate, for the first time to our knowledge, that alveolar microanatomy is critical in promoting the aggregation and, hence, in causing USA300-induced alveolar injury. (jci.org)
  • As augmented vascular leakage is a principal occurrence in the acute lung injury and thus, therapies are being targeted towards decreasing the leakage. (tmrresearch.com)
  • Ventilation Therapies and Strategies for Lung Injury. (routledge.com)
  • Anti-Inflammatory Therapies for Lung Injury. (routledge.com)
  • Surfactant-Based Therapies for Lung Injury. (routledge.com)
  • Fabeha Fazal, Ph.D. , assistant professor of Pediatrics and Neonatology at UR Medicine's Golisano Children's Hospital, has received a 4-year, $1.9M grant to identify viable therapies that will limit acute lung injury (ALI). (rochester.edu)
  • Thus, therapies that increase the activity of FOXF1 or S1P signaling could be used to decrease the complications that arise after acute lung injury, which can require hospitalization and can be fatal. (sciencemag.org)
  • This review highlights the role of CXCR2 in acute lung injury and discusses its potential as a therapeutic target. (hindawi.com)
  • These therapeutic cells employed integrins to stick to the site of injury and turn on cellular and molecular repair machinery. (thaindian.com)
  • The current findings demonstrate that ACE2 plays a critical role in influenza A (H7N9) virus-induced acute lung injury and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) outbreaks. (nature.com)
  • Observing that MSCs have beneficial therapeutic effects for lung injuries resulting from other types of bacterial and viral illnesses, the researchers studied the effects of MSC treatment on two flu viruses , H5N1 and H1N1. (medicalxpress.com)
  • Instead of damaged air sacs in the lungs, the teen had damaged airways, which his doctors believe were caused by chemical injury. (nugget.ca)
  • To measure lung dose the researchers sampled a lower airway cell called the airway macrophage - a specialised cell that sits on the airway surface and ingests foreign material. (eurekalert.org)
  • Interestingly, in the lung a compartmentalized role for the adhesion has been found, with LFA-1 being important on the vascular side and Mac-1 being important on the airway side ( 10 , 11 ). (jimmunol.org)
  • PMN migration into the lung proceeds by several steps upon an inflammatory stimulus: first, accumulation of PMNs in the capillaries, then transendothelial migration into the lung interstitium and finally, transepithelial migration into the alveolar space. (hindawi.com)
  • The most commonly seen abnormalities are a decrease in the expiratory reserve volume (ERV) and the functional residual capacity (FRC) with an unchanged residual volume (RV) and total lung capacity (TLC). (rtmagazine.com)
  • Radiation-induced lung injury (RILI) is a general term for damage to the lungs as a result of exposure to ionizing radiation. (wikipedia.org)
  • The research, which will be presented at the European Respiratory Society's Annual Congress in Amsterdam today (25 September 2011), suggests that cyclists inhale more black carbon than pedestrians, which may cause damage to the lungs. (eurekalert.org)