A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Pathological processes involving any part of the LUNG.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Tumors or cancer of the LUNG.
A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.
c-Kit positive cells related to SMOOTH MUSCLE CELLS that are intercalated between the autonomic nerves and the effector smooth muscle cells of the GASTROINTESTINAL TRACT. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
The transference of either one or both of the lungs from one human or animal to another.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
The fluid of the body that is outside of CELLS. It is the external environment for the cells.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Infection of the lung often accompanied by inflammation.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.
Measurement of volume of air inhaled or exhaled by the lung.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
Persistent abnormal dilatation of the bronchi.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Inhaling and exhaling the smoke of burning TOBACCO.
The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)
A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
An infant during the first month after birth.
Difficult or labored breathing.
Endoscopic examination, therapy or surgery of the bronchi.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A human infant born before 37 weeks of GESTATION.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
A pathological accumulation of air in tissues or organs.
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Elements of limited time intervals, contributing to particular results or situations.
Any hindrance to the passage of air into and out of the lungs.
The circulation of the BLOOD through the LUNGS.
Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A malignant epithelial tumor with a glandular organization.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Inflammation of the BRONCHIOLES.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Diseases caused by factors involved in one's employment.
Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
The excision of lung tissue including partial or total lung lobectomy.
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
An abnormal increase in the amount of oxygen in the tissues and organs.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.
Disease having a short and relatively severe course.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.
Substances that reduce or suppress INFLAMMATION.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Inflammation of a muscle or muscle tissue.
A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
An enzyme that activates histidine with its specific transfer RNA. EC
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The pressure due to the weight of fluid.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
The act of BREATHING out.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Relatively complete absence of oxygen in one or more tissues.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC
Inflammation of the lung parenchyma that is caused by a viral infection.
Drugs used for their effects on the respiratory system.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Granulomatous disorders affecting one or more sites in the respiratory tract.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Endoscopic surgery of the pleural cavity performed with visualization via video transmission.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.
Inflammation of the lung parenchyma that is caused by bacterial infections.
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.
Refers to animals in the period of time just after birth.
Measurement of oxygen and carbon dioxide in the blood.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Liquid components of living organisms.
Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Effect of hyperoxia on human macrophage cytokine response. (1/1082)

In the development of lung damage induced by oxidative stress, it has been proposed that changes in alveolar macrophages (AM) function with modifications in cytokine production may contribute to altered repair processes. To characterize the changes in profiles of cytokine production by macrophages exposed to oxidants, the effects of hyperoxia (95% O2) on interleukin (IL)-1 beta, IL-6, IL-8, and tumour necrosis factor-alpha (TNF-alpha) expression were studied. Experiments were first performed using AM obtained from control subjects and children with interstitial lung disease. Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8. To complete these observations we used U937 cells that were exposed for various durations to hyperoxia. We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8. Interestingly, this cytokine response was preceded during the first hours of O2 treatment by induction of TNF-alpha, IL-1 beta and IL-6. These data indicate that hyperoxia induces changes in the expression of macrophages inflammatory cytokines, and that these modifications appear to be influenced by the duration of O2 exposure.  (+info)

Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. (2/1082)

OBJECTIVE: To investigate the effect of ethnicity on clinical and serologic expression in patients with systemic sclerosis (SSc) and anti-DNA topoisomerase I (anti-topo I) antibody. METHODS: Clinical and serologic features, as well as HLA class II allele frequencies, were compared among 47 North American white, 15 North American black, 43 Japanese, and 12 Choctaw Native American SSc patients with anti-topo I antibody. RESULTS: The frequency of progressive pulmonary interstitial fibrosis was lower, and cumulative survival rates were better in white compared with black and Japanese patients. Sera of white and black patients frequently recognized the portion adjacent to the carboxyl terminus of topo I, sera of Japanese patients preferentially recognized the portion adjacent to the amino terminus of topo I, and sera of Choctaw patients recognized both portions of topo I. Anti-RNA polymerase II and anti-SSA/Ro antibodies were present together with anti-topo I antibody more frequently in sera of Japanese patients than in sera of white patients. The HLA-DRB1 alleles associated with anti-topo I antibody differed; i.e., DRB1*1101-*1104 in whites and blacks, DRB1*1502 in Japanese, and DRB1*1602 in Choctaws. Multivariate analysis showed that ethnic background was an independent determinant affecting development of severe lung disease as well as survival. CONCLUSION: Clinical and serologic features in SSc patients were strongly influenced by ethnic background. The variability of disease expression in the 4 ethnic groups suggests that multiple factors linked to ethnicity, including genetic and environmental factors, modulate clinical manifestations, disease course, and autoantibody status in SSc.  (+info)

Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group. (3/1082)

Leukemic patients receiving marrow from HLA-identical sibling donors were randomized to treatment with either busulfan 16 mg/kg (n = 88) or total body irradiation ([TBI] n = 79) in addition to cyclophosphamide 120 mg/kg. The patients were observed for a period of 5 to 9 years. Busulfan-treated patients had an increased risk of veno-occlusive disease (VOD) of the liver (12% v 1%, P =.01) and hemorrhagic cystitis (32% v 10%, P =.003). Acute graft-versus-host disease (GVHD) was similar in the two groups, but the 7-year cumulative incidence of chronic GVHD was 59% in the busulfan-treated group versus 47% in the TBI group (P =.05). Death from GVHD was more common in the busulfan group (22% v 3%, P <.001). Obstructive bronchiolitis occurred in 26% of the busulfan patients but in only 5% of the TBI patients (P <.01). Complete alopecia developed in 8 busulfan patients and partial alopecia in 17, versus five with partial alopecia in the TBI group (P <.001). Cataracts occurred in 5 busulfan-treated patients and 16 TBI patients (P =.02). The incidence of relapse after 7 years was 29% in both groups. Seven-year transplant-related mortality (TRM) in patients with early disease was 21% in the busulfan group and 12% in the TBI group. In patients with more advanced disease, the corresponding figures were 64% and 22%, respectively (P =.004). Leukemia-free survival (LFS) in patients with early disease was 68% in busulfan-treated patients and 66% in TBI patients. However, 7-year LFS in patients with more advanced disease was 17% in the busulfan group versus 49% in the TBI group (P <.01). In patients with chronic myeloid leukemia (CML) in first chronic phase, 7-year LFS was 72% and 83% in the two groups, respectively.  (+info)

Impact of cyclosporine and methylprednisolone dose used for prophylaxis and therapy of graft-versus-host disease on survival and relapse after allogeneic bone marrow transplantation. (4/1082)

In order to determine whether doses of cyclosporine and methylprednisolone used for prophylaxis and therapy of acute graft-versus-host disease (GVHD) have any influence on relapse and survival following allogeneic bone marrow transplantation (BMT), we studied 176 adult patients with hematologic malignancies, who underwent a first allogeneic transplant from an HLA-identical sibling donor. Two methods of management of acute GVHD used in two different centers were compared: group I included 62 patients who had 'standard' management of GVHD including prophylaxis with 1-3 mg/kg/day of cyclosporine and treatment with 2 mg/kg/day of methylprednisolone when acute GVHD developed; group II included 114 patients who received 'intensive' management of GVHD including prophylaxis with 5 mg/kg/day of cyclosporine and treatment with high-dose methylprednisolone (8-20 mg/kg/day for 3 days) at the onset of GVHD. The overall incidence of GVHD was the same in both groups. However, acute GVHD was more severe in group I than in group II (P < 0.0001), with consequently less resolution of GVHD after treatment in group I (61%) than in group II (80%) (P = 0.06). Overall survival and disease-free survival (DFS) did not differ between the two groups. However, actuarial risk of disease relapse was significantly higher in group II than in group I (36% vs 17%, P = 0.02). In a multivariate analysis taking into account known factors influencing GVHD and relapse, only type of GVHD management and age were significantly predictive for the occurrence of GVHD, while only type of GVHD management and pathology other than chronic myeloid leukemia (CML) were predictive for relapse. This study demonstrates that intensity of GVHD prophylaxis and therapy can influence the graft-versus-leukemia effect by decreasing severity of GVHD but at the price of increasing relapse rate post transplant.  (+info)

Pulmonary function abnormalities in children with Henoch-Schonlein purpura. (5/1082)

Henoch-Schonlein purpura (HSP) is a widespread necrotizing vasculitis affecting small vessels characterized by nonthrombocytopenic purpura. Pulmonary involvement is a rare fatal complication with diffuse alveolar haemorrhage. The objective of this study was to evaluate possible early lung function abnormalities and to establish any relationship with the clinical activity of the disease. Fifteen children with HSP and without clinical or radiological evidence of lung involvement underwent pulmonary function study at the onset of the disease. A sample of 28 subjects matched by age, height, and weight was chosen as a control group. After a mean of 21 months (range 12-43) lung function tests were repeated in 10 of the previously studied children. During the acute phase of the disease the transfer factor for carbon monoxide, measured by steady-state (TL,COss) and single-breath (TL,COsb) methods, was found to be significantly lower in children with HSP than control subjects. There was no significant relationship between pulmonary function tests with symptoms and signs at onset, nor was there any correlation between variables and serum immunoglobulin A (IgA) concentration. In all but two patients, clinical recovery was observed within 6 weeks from the onset of the disease. In one case relapses of purpuric skin lesions were observed during the first 3 months of follow-up. The second case had relapses of purpuric skin lesions and microscopical haematuria during the 12 months following the onset of the disease with characteristic IgA mesangial deposition on renal biopsy. Although the overall mean value of TL,COsb improved from baseline to the second investigation, in both patients the recurrences of clinical signs were associated with a slight impairment of TL,COsb at the second evaluation. These data suggest an early subclinical lung impairment in children with Henoch-Schonlein purpura during the active phase of the disease. The presence of isolated pulmonary function abnormalities was not associated with the subsequent development of lung disease.  (+info)

Pediatric AIDS-associated lymphocytic interstitial pneumonia and pulmonary arterio-occlusive disease: role of VCAM-1/VLA-4 adhesion pathway and human herpesviruses. (6/1082)

Because the mechanisms of lymphocyte accumulation in the lungs of children with AIDS-associated lymphocytic interstitial pneumonia (LIP) are unknown, we studied the relative contributions of known adhesion pathways in mediating lymphocyte adherence to endothelium and the potential role of human herpesviruses in the expansion of these lesions. LIP was characterized by lymphoid hyperplasia of the bronchus-associated lymphoid tissue (BALT) and infiltration of the pulmonary interstitium with CD8(+) T lymphocytes. In some individuals there was expansion of the alveolar septae with dense aggregates of B lymphocytes, many containing the Epstein-Barr viral (EBV) genome. Patients with concurrent EBV infection also demonstrated large-vessel arteriopathy characterized by thickening of the intimae with collagen and smooth muscle. Venular endothelium from the lung of children with LIP, but not uninflamed lung from other children with AIDS or lung from children with nonspecific pneumonitis, expressed high levels of vascular cell adhesion molecule-1 (VCAM-1) protein. In turn, inflammatory cells expressing very late activation antigen-4 (VLA-4), the leukocyte ligand for VCAM-1, were the predominant perivascular infiltrate associated with vessels expressing VCAM-1. Expression of other endothelial adhesion molecules, including intracellular adhesion molecule-1 and E-selectin, was not uniformly associated with LIP. Using a tissue adhesion assay combined with immunohistochemistry for VCAM-1, we show that CD8(+) T cell clones that express VLA-4 bind preferentially to pulmonary vessels in sites of LIP: vessels that expressed high levels of VCAM-1. When tissues and cells were pretreated with antibodies to VCAM-1 or VLA-4, respectively, adhesion was inhibited by >/=80%. Thus, infiltration of alveolar septae with CD8(+) T cells was highly correlative with VCAM-1/VLA-4 adhesive interactions, and focal expansion of B cells was coincidental to co-infection with EBV.  (+info)

Idiopathic interstitial pneumonias: clinical findings, pathogenesis, pathology and radiologic findings. (7/1082)

Idiopathic interstitial pneumonias are currently classified into four categories: usual interstitial pneumonia, nonspecific interstitial pneumonia with fibrosis, acute interstitial pneumonia and desquamative interstitial pneumonia. The fibrotic process in interstitial pneumonias appears to result from a complex interaction between fibroblasts, other lung parenchymal cells and macrophages. The complex relationship between the local release of growth-promoting cytokines by alveolar macrophages and resident fibroblasts represents a necessary step for fibrosis or remodeling after lung injury. Injury to the epithelium and basement membranes is likely necessary for the fibrotic process to occur. Usual interstitial pneumonia, most frequent among interstitial pneumonias and has a poor prognosis, appears on high-resolution CT as patchy subpleural areas of ground-glass attenuation, irregular linear opacity, and honeycombing. Nonspecific interstitial pneumonia with fibrosis, the second most frequent and has a better prognosis than usual interstitial pneumonia, appears as subpleural patchy areas of ground-glass attenuation with associated areas of irregular linear opacity on CT. Acute interstitial pneumonia with high mortality rate presents as extensive bilateral airspace consolidation and patchy or diffuse bilateral areas of ground-glass attenuation. Desquamative interstitial pneumonia with good prognosis presents as patchy subpleural areas of ground-glass attenuation in middle and lower lung zones.  (+info)

Finding-specific display presets for computed radiography soft-copy reading. (8/1082)

Much work has been done to optimize the display of cross-sectional modality imaging examinations for soft-copy reading (i.e., window/level tissue presets, and format presentations such as tile and stack modes, four-on-one, nine-on-one, etc). Less attention has been paid to the display of digital forms of the conventional projection x-ray. The purpose of this study is to assess the utility of providing presets for computed radiography (CR) soft-copy display, based not on the window/level settings, but on processing applied to the image optimized for visualization of specific findings, pathologies, etc (i.e., pneumothorax, tumor, tube location). It is felt that digital display of CR images based on finding-specific processing presets has the potential to: speed reading of digital projection x-ray examinations on soft copy; improve diagnostic efficacy; standardize display across examination type, clinical scenario, important key findings, and significant negatives; facilitate image comparison; and improve confidence in and acceptance of soft-copy reading. Clinical chest images are acquired using an Agfa-Gevaert (Mortsel, Belgium) ADC 70 CR scanner and Fuji (Stamford, CT) 9000 and AC2 CR scanners. Those demonstrating pertinent findings are transferred over the clinical picture archiving and communications system (PACS) network to a research image processing station (Agfa PS5000), where the optimal image-processing settings per finding, pathologic category, etc, are developed in conjunction with a thoracic radiologist, by manipulating the multiscale image contrast amplification (Agfa MUSICA) algorithm parameters. Soft-copy display of images processed with finding-specific settings are compared with the standard default image presentation for 50 cases of each category. Comparison is scored using a 5-point scale with the positive scale denoting the standard presentation is preferred over the finding-specific processing, the negative scale denoting the finding-specific processing is preferred over the standard presentation, and zero denoting no difference. Processing settings have been developed for several findings including pneumothorax and lung nodules, and clinical cases are currently being collected in preparation for formal clinical trials. Preliminary results indicate a preference for the optimized-processing presentation of images over the standard default, particularly by inexperienced radiology residents and referring clinicians.  (+info)

To the editor: Lymphocytic interstitial pneumonitis may be another example of the overlapping spectrum of benign lymphoid proliferation, malignant lymphoma, and autoimmune disease. Disorders likely to be autoimmune that have been described (1) with lymphocytic interstitial pneumonitis include myasthenia gravis, pernicious anemia, Sjögrens syndrome, autoerythrocyte sensitization, and chronic active hepatitis. We supplement this list by describing the case of a patient with lymphocytic interstitial pneumonitis who had autoimmune hemolytic anemia, probable autoimmune neutropenia and thrombocytopenia, and perhaps autoimmune liver and thyroid disease.. A 34-year-old man was admitted to the New England Deaconess Hospital in July 1976 because of peripheral lymphadenopathy, ...
Looking for desquamative interstitial pneumonia? Find out information about desquamative interstitial pneumonia. in agriculture, method of treating animals infested with skin parasites such as mites, ticks, and warbles. The animal is dipped into or forced to swim... Explanation of desquamative interstitial pneumonia
Definition of progressive interstitial pneumonia in sheep in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is progressive interstitial pneumonia in sheep? Meaning of progressive interstitial pneumonia in sheep as a legal term. What does progressive interstitial pneumonia in sheep mean in law?
interstitial lung disease - MedHelps interstitial lung disease Center for Information, Symptoms, Resources, Treatments and Tools for interstitial lung disease. Find interstitial lung disease information, treatments for interstitial lung disease and interstitial lung disease symptoms.
Thirteen patients with lymphocytic interstitial pneumonitis were seen at the Mayo Clinic from 1966 through 1976. The group included nine women and four men, with a mean age of 50.7 years. Their primary complaints were cough, dyspnea, and loss of weight. Chest roentgenographic features were predominantly basilar, coarse interstitial-alveolar infiltrations. Pulmonary function studies showed restrictive ventilatory impairments with a low CO diffusing capacity in all 13 patients. Lung biopsies in all cases showed diffuse interstitial infiltrations, consisting of mature lymphocytes and plasma cells. Ten of the 13 patients had an associated dysproteinemia, including two patients with hypogammaglobulinemia. Three patients had coexistent Sjögrens syndrome, including two with localized amyloidosis. Although lymphocytic interstitial pneumonitis is a histologically distinct pulmonary lesion, it occurs with a variety of immune disorders. ...
A subset of patients with common variable immunodeficiency (CVID) develops granulomatous and lymphocytic interstitial lung disease (GLILD), a restrictive lung disease associated with early mortality.
TY - JOUR. T1 - Evidence for chronic inflammation as a component of the interstitial lung disease associated with progressive systemic sclerosis. AU - Rossi, G. A.. AU - Bitterman, P. B.. AU - Rennard, S. I.. AU - Ferrans, V. J.. AU - Crystal, R. G.. PY - 1985. Y1 - 1985. N2 - Progressive systemic sclerosis (PSS) is a generalized disorder characterized by fibrosis of many organs including the lung parenchyma. Unlike most other interstitial disorders, traditional concepts of the interstitial lung disease associated with PSS have held it to be a pure fibrotic disorder without a significant inflammatory component. To directly evaluate whether an active alveolitis is associated with this disorder, patients with chronic interstitial lung disease and PSS were studied by open lung biopsy, gallium-67 scanning, and bronchoalveolar lavage. Histologic evaluation of the biopsies demonstrated that the interstitial fibrosis of PSS is clearly associated with the presence of macrophages, lymphocytes, and ...
Explore pulmonary rehabilitation. National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/pulreh. Accessed March 14, 2018.. Interstitial lung disease. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T900225/Interstitial-lung-disease . Updated January 23, 2018. Accessed March 14, 2018. Interstitial lung disease (ILD). British Lung Foundation website. Available at: https://www.blf.org.uk/support-for-you/interstitial-lung-disease-ild. Accessed March 14, 2018.. Overview of interstitial lung disease. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/pulmonary-disorders/interstitial-lung-diseases/overview-of-interstitial-lung-disease. Updated April 2016. Accessed March 14, 2018.. Schraufnagel DE. Chapter 10: Interstitial lung disease. American Thoracic Society website. Available at: ...
From granuloma to fibrosis in interstitial lung diseases molecular disease (ild) and pulmonary (pf)the association. Googleusercontent search. Interstitial lung disease (ild) or pulmonary fibrosis refers to more than 200 chronic disorders. Interstitial lung diseases vs. These disorders generally are chronic interstitial lung diseases may also be called pulmonary fibrosis or the condition remain same for long periods of time it change 19 nov 2015 in people with disease, this tissue becomes stiff scarred, and air sacs not able to expand as much. Pulmonary fibrosis idiopathic, stages, signs & life expectancy. Interstitial lung disease the. With ild, the tissue between air sacs of lungs (the interstitium) is affected by inflammation or scarring (fibrosis). For example idiopathic pulmonary fibrosis (ipf) is a form of ild without 11 jun 2015 interstitial lung disease unknown cause predominated by fibrosis, specific and progressive fibrotic disease, what are the symptoms disease? How most common. With ...
From granuloma to fibrosis in interstitial lung diseases molecular disease (ild) and pulmonary (pf)the association. Googleusercontent search. Interstitial lung disease (ild) or pulmonary fibrosis refers to more than 200 chronic disorders. Interstitial lung diseases vs. These disorders generally are chronic interstitial lung diseases may also be called pulmonary fibrosis or the condition remain same for long periods of time it change 19 nov 2015 in people with disease, this tissue becomes stiff scarred, and air sacs not able to expand as much. Pulmonary fibrosis idiopathic, stages, signs & life expectancy. Interstitial lung disease the. With ild, the tissue between air sacs of lungs (the interstitium) is affected by inflammation or scarring (fibrosis). For example idiopathic pulmonary fibrosis (ipf) is a form of ild without 11 jun 2015 interstitial lung disease unknown cause predominated by fibrosis, specific and progressive fibrotic disease, what are the symptoms disease? How most common. With ...
TY - JOUR. T1 - Correlation of antisynthetase antibody levels with disease course in a patient with interstitial lung disease and elevated muscle enzymes. T2 - Quantitation of antiglycyl tRNA synthetase antibodies by immunoprecipitation. AU - Stojanov, Lovorka. AU - Satoh, Minoru. AU - Hirakata, Michito. AU - Reeves, Westley H.. PY - 1996/4. Y1 - 1996/4. N2 - Antiglycyl tRNA synthetase is an unusual autoantibody specificity associated with polymyositis and dermatomyositis complicated by interstitial lung disease. We report here autoantibodies to glycyl tRNA synthetase in a patient with systemic lupus erythematosus and interstitial lung disease. During the course of her disease, the patient developed elevated muscle enzymes and worsening pulmonary function. A quantitative immunoprecipitation technique was developed to evaluate the relationship between autoantibody production and clinical manifestations in this patient. Increasing serum antiglycyl tRNA synthetase antibody levels correlated with ...
The ERS-education website provides centralised access to all educational material produced by the European Respiratory Society. It is the worlds largest CME collection for lung diseases and treatment offering high quality e-learning and teaching resources for respiratory specialists. This distance learning portal contains up-to-date study material for the state-of-the-art in Pulmonology.
As subpleural interlobular septa thicken among air-filled alveoli, they create a medium in which incident ultrasound waves will reverberate within, creating a short path reverberation artifact. Feb 18, 2014 - The differential diagnosis of nodules in a perilymphatic distribution is limited : the most common cause is sarcoidosis (typically symmetrical and upper lobes) also common is lymphangitis carcinomatosis Desquamative Interstitial Pneumonia Desquamative interstitial pneumonia (DIP) is another idiopathic interstitial disease that occasionally ends with honeycombing fibrosis.90,23590235 However, severe honeycombing fibrosis is a less-frequent complication of DIP … UIP is thus classified as a form of interstitial lung disease. Nonspecific interstitial pneumonia (NSIP) has variable clinical, patho-logic, and radiologic manifestations. It has a variety of underlying causes, with a common etiology of chronic inflammation. We report the main features of ICI-ILD with a … The purpose of this study ...
Interstitial lung diseases (ILDs) in children represent a heterogeneous group of rare respiratory disorders that affect the lung parenchyma. After the launch of the French Reference Centre for Rare Lung Diseases (RespiRare®), we created a national network and a web-linked database to collect data on pediatric ILD. Since 2008, the database has been set up in all RespiRare® centres. After patients parents oral consent is obtained, physicians enter the data of children with ILD: identity, social data and environmental data; specific aetiological diagnosis of the ILD if known, genetics, patient visits to the centre, and all medical examinations and tests done for the diagnosis and/or during follow up. Each participating centre has a free access to his own patients data only, and cross-centre studies require mutual agreement. Physicians may use the system as a daily aid for patient care through a web-linked medical file, backed on this database. Data was collected for 205 cases of ILD. The M/F sex ratio
Interstitial lung disease is a group of conditions with inflammation and scarring around the tiny air sacs (alveoli) in the lungs. The changes make it hard to take in oxygen. Often the cause is unknown. This is called idiopathic pulmonary fibrosis. Known causes are conditions such as sarcoidosis and rheumatoid arthritis. Breathing in certain substances such as mold, fungus, or asbestos are also known causes. Some medicines and radiation treatments can also cause interstitial lung disease.. When you have interstitial lung disease, youre more likely to get lung infections. Do what you can to prevent infections. And get treatment right away at the first sign of illness.. ...
TY - JOUR. T1 - Clinicoserological features of antisynthetase syndrome (ASyS)-associated interstitial lung disease presenting to respiratory services. T2 - comparison with idiopathic pulmonary fibrosis and ASyS diagnosed in rheumatology services. AU - Barratt, Shaney L. AU - Adamali, Havra H. AU - Cotton, Caroline. AU - Mulhearn, Ben. AU - Iftikhar, Hina. AU - Pauling, John David. AU - Spencer, Lisa. AU - Adamali, Huzaifa I. AU - Gunawardena, Harsha. N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.. PY - 2021/1. Y1 - 2021/1. N2 - INTRODUCTION: Antisynthetase syndrome (ASyS) is a rare autoimmune connective tissue disease (CTD), associated with autoantibodies targeting tRNA synthetase enzymes, that can present to respiratory (interstitial lung disease (ILD)) or rheumatology (myositis, inflammatory arthritis and systemic features) services. The therapeutic management of CTD-associated ILD and ...
RATIONALE:Domiciliary oxygen therapy is commonly prescribed for patients with interstitial lung disease and hypoxemia, either at rest or during exertion, with the aim of improving symptoms and functional status. OBJECTIVES:This study aimed to explore perspectives of adults with interstitial lung disease about domiciliary oxygen therapy, comparing insights from patients using and not using oxygen therapy. METHODS:A qualitative study using semistructured interviews was undertaken on 24 adults residing in and near Melbourne, Australia who had a diagnosis of interstitial lung disease and met the Thoracic Society of Australia and New Zealand guidelines for domiciliary oxygen therapy. Study subjects included individuals who were oxygen-naive (n = 12) and oxygen-experienced (n = 12). Interviews were transcribed verbatim and coded independently by two investigators in accordance with the grounded theory method of analysis. Themes were established by consensus. RESULTS:Patients using domiciliary oxygen ...
Archivos de Bronconeumologia is a scientific journal that preferentially publishes prospective original research articles whose content is based upon results dealing with several aspects of respiratory diseases such as epidemiology, pathophysiology, clinics, surgery, and basic investigation. Other types of articles such as reviews, editorials, a few special articles of interest to the society and the editorial board, scientific letters, letters to the Editor, and clinical images are also published in the Journal. It is a monthly Journal that publishes a total of 12 issues and a few supplements, which contain articles belonging to the different sections ...
TY - JOUR. T1 - Impact of the pattern of interstitial lung disease on mortality in rheumatoid arthritis. T2 - A systematic literature review and meta-analysis. AU - Singh, Namrata. AU - Varghese, Jimmy. AU - England, Bryant R.. AU - Solomon, Joshua J.. AU - Michaud, Kaleb. AU - Mikuls, Ted R.. AU - Healy, Heather S.. AU - Kimpston, Emily M.. AU - Schweizer, Marin L.. N1 - Publisher Copyright: © 2019. PY - 2019/12. Y1 - 2019/12. N2 - Objective: An important extra-articular manifestation of rheumatoid arthritis (RA) is interstitial lung disease (ILD). The relationship between the usual interstitial pneumonia (UIP) pattern and mortality in patients with RA is unclear. The purpose of this study was to complete a systematic literature review and meta-analysis on the association between RA-ILD pattern and mortality risk. Methods: We performed a systematic literature review through December 12, 2018. Study characteristics, unadjusted and adjusted relative risks (RR) of mortality for ILD pattern were ...
Idiopathic pulmonary fibrosis (IPF) the prototype of interstitial lung diseases has the worst prognosis and is the only interstitial lung disease for which approved pharmacological treatments are available. test for IPF. Further obtaining reliable lung function tests and providing treatment access is difficult in the more rural areas of these countries. However IPF might represent an opportunity for BRIC countries: the exponentially increasing demand for the enrollment of IPF individuals in clinical tests of new medicines is predicted to handle a lack of individuals - BRIC countries may therefore play an essential role in improving towards an end to IPF. and visitor editor for this article collection Idiopathic Pulmonary … Idiopathic pulmonary fibrosis (IPF) may be the prototype of interstitial lung illnesses (ILDs) several pulmonary illnesses generally known as uncommon lung illnesses. A uncommon disease is described by europe as you that affects significantly less than 5 in 10 0 of the ...
Background and objective: To describe the clinical characteristics including the bronchoalveolar lavage fluid (BALF) characteristics of patients with antisynthetase syndrome (AS) associated interstitial lung disease (ILD) in a tertiary ILD outpatient clinic, their medical therapy and outcome. Methods: Retrospective cohort study of patients with AS-ILD. All available data of clinical characteristics, pulmonary function tests, laboratory parameters, BALF analysis, histology, high-resolution computed tomography (HRCT) and treatment were collected from the patient files. Results and conclusions: Twelve patients with AS-ILD were identified. Mean age at diagnosis was 55 years (range 45-69), 67% were female. Mean follow-up time was 7 years. The anti-aminoacyl tRNA-synthetase antibodies presented were anti-Jo1 (n = 6), anti-PL7 (n = 3), anti-PL12 (n = 2) and anti-EJ (n = 1). HRCT patterns were mainly non-specific interstitial pneumonia (75%). Four patients had BALF-eosinophilia (two of four anti-Jo1 ...
Dr. Shane Shapera, discusses the treatment of Scleroderma interstitial lung disease (SSc-ILD). At the end of this talk, listeners will be able to describe what Scleroderma interstitial lung disease means and better understand the risk factors for SSc-ILD development and its progression and the evidence for and against anti-inflammatory and anti-fibrotic treatment of SSc-ILD.
Results:. The main associated diseases with LIP were Sjögren syndrome (42%), human immunodeficiency virus infection (17%), amyloidosis (17%), Sjögren syndrome associated with secondary amyloidosis (11%), idiopathic (8%), and systemic lupus erythematosus (5%). The predominant CT abnormalities were multiple cystic airspaces (n = 35), small nodules (n = 15), ground-glass opacities (n = 13), bronchiectasis and/or bronchiolectasis (n = 8), and thickening of the bronchovascular bundles (n = 8). Other CT findings included reticular opacities (n = 7), calcified nodules (n = 4), airspace consolidation (n = 4), emphysema (n = 3), honeycombing (n = 3), lymph node enlargement (n = 2), mosaic attenuation pattern (n = 1), and cavitated nodules (n = 1). ...
Interstitial lung disease (ILD) is an umbrella term for disorders involving scarring or inflammation of the tissue surrounding the air sacs in the lungs. Since many patients with ILD get worse over time, getting a diagnosis and beginning treatment as soon as possible is important.. Doctors at Temples Interstitial Lung Disease Program see patients with all types of ILD, including idiopathic pulmonary fibrosis (IPF), sarcoidosis, acute interstitial pneumonitis (AIP), bleomycin-induced pneumonitis (BIP), scleroderma-related lung disease, other connective-tissue disease associated ILDs (CT-ILD), hypersensitivity pneumonitis (HP), and others.. The team at Temple use a multi-disciplinary approach to diagnose and treat ILD. Using this approach, the ILD team is often able to diagnose patients without the need for a lung biopsy. Instead, Temples multi-disciplinary committee uses non-invasive, high-resolution scans to diagnose most patients. When a lung biopsy is necessary, Temples ILD physicians offer ...
has illustrated the range of pathology.. At the university hospital in Lusaka between 15 September 1997 and 15 June 2000 a total of 1603 children aged between 1 month an 16 years died from respiratory illnesses. Of those parents approached for permission for a restricted (chest only) autopsy 75% refused. Two hundred and sixty-four autopsies were performed. Multiple lung pathology was common; a total of 357 main diagnoses were made in the 264 children. They included acute pyogenic pneumonia (44%), Pneumocystis carinii pneumonia (22%), tuberculosis (20%), cytomegalovirus infection (16%) (mostly mild but three cases of severe necrotising CMV pneumonia), interstitial pneumonitis (11%), shock lung (10%), pulmonary oedema (7%), and lymphocytic interstitial pneumonia (4%). Seven children had measles.. One hundred and eighty of the 264 children were HIV-positive. P carinii pneumonia, CMV, shock lung, and lymphocytic interstitial pneumonitis were more common in the HIV-positive group although acute ...
Interstitial lung disease, or ILD, includes more than 100 chronic lung disorders. These diseases are not cancer and are not caused by an infection. Interstitial lung diseases are named after the tissue between the air sacs of the lungs called the interstitium.
The aphorism that children are not little adults certainly applies for the imaging of interstitial lung disease. Acquiring motion-free images of fine pulmonary structures at desired lung volumes is much more difficult in children than in adults. Several forms of interstitial lung disease are unique …
Reata Pharmaceuticals has linked its Nrf2 transcription factor activator to improved six-minute walk test results in patients with interstitial lung disease (ILD). The results come from a small, exploratory study Reata initiated after wrapping up a trial of the drug in its primary indication.
TY - JOUR. T1 - Significance of granulomatous inflammation in usual interstitial pneumonia. AU - Tomic, R.. AU - Kim, H. J.. AU - Bors, M.. AU - Allen, T.. AU - Ritter, J.. AU - Dincer, E. H.. AU - Perlman, D. M.. AU - Bhargava, M.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Sarcoidosis is a systemic granulomatous disease of unclear etiology with characteristic pulmonary lesions. We describe 2 unique cases of sarcoidosis where after approximately 20 years of clinical quiescence, patients developed interstitial opacities on chest CT scan and an increase in shortness of breath. With lack of therapeutic response to a course of prednisone, both patients underwent a surgical lung biopsy that revealed a pattern consistent with Usual Interstitial Pneumonia (UIP) with honeycombing and fibroblastic foci. Postoperatively, the course of the disease was consistent with what would be expected in Idiopathic Pulmonary Fibrosis. Ultimately the disease progressed with one patient needed lung transplantation and the ...
TY - JOUR. T1 - Role of microorganisms in interstitial lung disease. AU - Vanfleteren, L.E.. AU - Linssen, C.F.M.. PY - 2010/1/1. Y1 - 2010/1/1. N2 - PURPOSE OF REVIEW: To review the role of microorganisms in interstitial lung disease (ILD) and to emphasize their importance in initiation and course of ILD. RECENT FINDINGS: ILD can be idiopathic but often causality such as drugs or connective tissue disease can be found. Multiple microorganisms have been associated with ILD. On the one hand, pulmonary infection can cause extensive pulmonary damage with patterns of an ILD. On the other hand, microorganisms can trigger the immune system and provoke an abnormal response- not directed against the causative pathogen- that may result in ILD. Moreover, patients with ILD often are susceptible to infection, and infections can importantly influence the course of ILD. Furthermore, not only an infection but also its treatment can result in a drug-induced pneumonitis, eventually resulting in long-term lung ...
AIMS We hypothesise that ER stress may be involved in the pathogenesis of fibrosis in all interstitial lung diseases.. Paraffin embedded lung biopsy sections from 8 patients with familial pulmonary fibrosis, 11 sporadic idiopathic pulmonary fibrosis (IPF), 12 non-specific interstitial pneumonia (NSIP) and 10 hypersensitivity pneumonitis (HP) were evaluated for BiP and GADD34 by immunohistochemistry. Using light microscopy, 6 high power fields were scored for fibrosis, inflammation, BiP and GADD34 using semi-quantitative analysis by 2 blinded, independent investigators. Data were analysed by linear regression using Prism software.. BiP and GADD34 were localised to reactive type II pneumocytes and columnar epithelium within areas of fibrosis. GADD34 was also evident in the endothelium. No staining was detected in fibroblasts. Epithelial GADD34 correlated with extent of fibrosis in familial pulmonary fibrosis (r2 = 0.72, p , 0.001), IPF (r2 = 0.51, p , 0.0001) and NSIP (r2 = 0.46, p , 0.0001). In ...
Interstitial lung disease with pulmonary fibrosis. Illustration based on a 3D computed tomography (CT) scan of the lungs of a patient with interstitial lung disease (ILD) that has developed into pulmonary fibrosis. ILD is a group of lung diseases that affect the tissue in the alveoli (air sacs) of the lungs. Most of these diseases later develop fibrosis (the formation of thickened scar tissue) in the lungs. ILD results in loss of lung volume, impairing gaseous exchange and causing shortness of breath. - Stock Image C036/0521
There have been numerous reports of interstitial lung disease associated with the use of the new disease modifying anti-rheumatic drug leflunomide. This epidemiological study examined the risk of developing interstitial lung disease (ILD) in patients on leflunomide.. Data from 62 734 patients with rheumatoid arthritis were examined in a case-control study. The risk of ILD was not higher for patients on leflunomide provided they had no previous methotrexate use or a history of ILD (relative risk (RR) 1.2, 95% confidence interval (CI) 0.4 to 3.1). There was, however, an increased risk of ILD with leflunomide in patients who did have a history of previous methotrexate use or ILD (RR 2.6, 95% CI 1.2 to 5.6).. The use of leflunomide as a disease modifying anti-rheumatic drug is increasing in patients with rheumatoid arthritis and reports of ILD are rising. Respiratory physicians should be aware of the potential for developing ILD.. ...
TY - JOUR. T1 - Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer. AU - Kawata, Toshio. AU - Higashimori, Mitsuo. AU - Itoh, Yohji. AU - Tomkinson, Helen. AU - Johnson, Martin G.. AU - Tang, Weifeng. AU - Nyberg, Fredrik. AU - Jiang, Haiyi. AU - Tanigawara, Yusuke. PY - 2019/5/1. Y1 - 2019/5/1. N2 - Purpose: A prospective, multicenter, large-scale cohort with a nested case-control study (NCT00252759) was conducted to identify and quantify risk factors for interstitial lung disease (ILD) in Japanese patients with non-small-cell lung cancer who received gefitinib. This study reports the association between gefitinib exposure and the occurrence of ILD. Methods: A total of 1891 gefitinib plasma concentrations from 336 patients were measured after first dose, at steady state, and at time of ILD occurrence. Influences of demographic and pathophysiological factors on pharmacokinetics were investigated by non-linear mixed-effect modeling. ...
The lungs contain tiny air sacs (alveoli), which is where oxygen is absorbed. These air sacs expand with each breath.. The tissue around these air sacs is called the interstitium. In people with interstitial lung disease, this tissue becomes stiff or scarred, and the air sacs are not able to expand as much. As a result, not as much oxygen can get to the body.. Interstitial lung disease (ILD) can occur without a known cause. This is called idiopathic ILD. Idiopathic pulmonary fibrosis (IPF) is the most common disease of this type.. There are also dozens of known causes of ILD, including:. ...
TY - JOUR. T1 - A Primer on Interstitial Lung Disease and Thoracic Radiation. AU - Goodman, Christopher D. AU - Nijman, Suzan F M. AU - Senan, Suresh. AU - Nossent, Esther J. AU - Ryerson, Christopher J. AU - Dhaliwal, Inderdeep. AU - Qu, Melody. AU - Laba, Joanna. AU - Rodrigues, George. AU - Palma, David A. AU - International Association for the Study of Lung Cancer Advanced Radiation Technology Committee. N1 - Copyright © 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.. PY - 2020/6. Y1 - 2020/6. N2 - Interstitial lung disease (ILD) is a term used to describe a heterogeneous group of lung disorders with characteristic clinical and imaging features. Patients with ILD are at an increased risk of developing non-small cell lung cancer and are frequently medically comorbid often precluding operative management. In this scenario, radiotherapy (RT) is generally recommended however ILD is known to increase the risk of RT-related toxicity. ...
TY - JOUR. T1 - Vitronectin in bronchoalveolar lavage fluid is increased in patients with interstitial lung disease. AU - Pohl, W. R.. AU - Conlan, M. G.. AU - Thompson, A. B.. AU - Ertl, R. F.. AU - Romberger, D. J.. AU - Mosher, D. F.. AU - Rennard, S. I.. PY - 1991. Y1 - 1991. N2 - Vitronectin, also known as S-protein, is a 75,000-dalton serum glycoprotein that has a variety of functions, including the capacity to interact with the terminal components of the complement cascade, the coagulation system, and cell surfaces. By virtue of its ability to interact with cells, vitronectin is capable of mediating cell-spreading and adhesion and may also influence cell differentiation and cell growth. To investigate the possibility that vitronectin might contribute to the pathogenesis of interstitial lung disease, vitronectin was measured in bronchoalveolar lavage fluid from patients with sarcoidosis, idiopathic pulmonary fibrosis, and, for comparison, normal volunteers. Vitronectin was detected in ...
TY - JOUR. T1 - Prognosticating outcomes in interstitial lung disease by mediastinal lymph node assessment. AU - Adegunsoye, Ayodeji. AU - Oldham, Justin. AU - Bonham, Catherine. AU - Hrusch, Cara. AU - Nolan, Paul. AU - Klejch, Wesley. AU - Bellam, Shashi. AU - Mehta, Uday. AU - Thakrar, Kiran. AU - Pugashetti, Janelle Vu. AU - Husain, Aliya N.. AU - Montner, Steven M.. AU - Straus, Christopher M.. AU - Vij, Rekha. AU - Sperling, Anne I.. AU - Noth, Imre. AU - Strek, Mary E.. AU - Chung, Jonathan H.. PY - 2019/3/15. Y1 - 2019/3/15. N2 - Rationale: Mediastinal lymph node (MLN) enlargement on chest computed tomography (CT) is prevalent in patients with interstitial lung disease (ILD) and may reflect immunologic activation and subsequent cytokine-mediated immune cell trafficking. Objectives: We aimed to determine whether MLN enlargement on chest CT predicts clinical outcomes and circulating cytokine levels in ILD. Methods: MLN measurements were obtained from chest CT scans of patients with ILD at ...
Antibiotics. Advertising on our site helps support our mission. Some types of ILD may respond quickly, and others may not respond at all. Even with treatment, many types of ILD progress naturally with a worsening of symptoms, X-ray findings and physiologic findings. Although there is little debate about the use of supplemental oxygen and diuretic therapy in the treatment of PH-ILD, treatment with pulmonary vasodilator therapy remains controversial. The prognosis of interstitial lung disease depends on the precise cause. Sometimes worsening is due to a complication of the disease or therapy. Usually, the scarring of the lungs that occurs with interstitial lung disease (ILD) is not reversible, but treatments that improve lung function are available for diseases which include active inflammation. Others help improve quality of life.Because many of the different types of scarring disorders have no approved or proven therapies, clinical studies may be an option to receive an experimental treatment.
The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case-control study Ted Rosenberg,1 Rory Lattimer,2 Patrick Montgomery,3 Christian Wiens,4 Liran Levy5 1Department of Family Medicine, University of British Columbia and Island Medical Program, Victoria, BC, 2Home Team Medical Services, Victoria, BC, 3Division of Geriatric Medicine, University of British Columbia, Victoria, BC, 4Geriatric Psychiatry, University of British Columbia, Victoria, BC, 5Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada Background: The association between interstitial lung disease (ILD) and selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors (SSRI/SNRI) has been previously described in published case reports. However, its prevalence may be more common than expected. We examined the association between SSRI/SNRI usage and presence of ILD and or bronchiectasis (ILD/B) in an elderly population.Methods: We
TY - JOUR. T1 - Connective tissue disease-associated interstitial lung diseases (CTD-ILD) - Report from OMERACT CTD-ILD working group. AU - Khanna, Dinesh. AU - Mittoo, Shikha. AU - Aggarwal, Rohit. AU - Proudman, Susanna M.. AU - Dalbeth, Nicola. AU - Matteson, Eric L.. AU - Brown, Kevin. AU - Flaherty, Kevin. AU - Wells, Athol U.. AU - Seibold, James R.. AU - Strand, Vibeke. N1 - Publisher Copyright: The Journal of Rheumatology Copyright © 2015. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2015/11. Y1 - 2015/11. N2 - Objective. Interstitial lung disease (ILD) is common in connective tissue disease (CTD) and is the leading cause of mortality. Investigators have used certain outcome measures in randomized controlled trials (RCT) in CTD-ILD, but the lack of a systematically developed, CTD-specific index that captures all measures relevant and meaningful to patients with CTD-ILD has left a large and conspicuous gap in CTD-ILD research. Methods. The ...
Our study was designed to correlate the degree of parenchymal affection in idiopathic interstitial pneumonia using visual and semi-quantitative HRCT assessment with pulmonary function test results. The study involved 50 patients diagnosed as idiopathic interstitial pneumonia. They were referred from a chest outpatient clinic to the Radiology Department in the Faculty of Medicine, Cairo University for HRCT assessment in the period from January 2017 to March 2019. Variable lung parenchymal affection was studied using HRCT and variable post acquisition processing (multi-planar reconstruction, volumetric assessment, 3D color-coded images). Usual interstitial pneumonia was the most common type of IP, found in approximately 40 patients (80% of cases) followed by nonspecific interstitial pneumonia found in 5 patients (10% of cases) and lymphocytic interstitial pneumonia found in 3 patients (6% of cases), and desquamative interstitial pneumonia was the least common type of IP, found only in 2 patients (4% of
Objective: To investigate the timing and complications of lung transplantation for the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). Method: The clinical data of connective tissue-associated disease lung transplantation recipients from September, 2015 to February, 2017 were collected. Results: 11 patients with CTD-ILD were evaluated by lung transplantation and were treated with lung transplantation. Including 2 cases dermatomyositis/polymyositis and interstitial lung disease (PM/DM-ILD), 4 cases rheumatoid arthritis and interstitial lung disease (RA-ILD), 4 cases of primary Sjgrens syndrome and interstitial lung disease (pSS-ILD), 1 case of systemic sclerosis and interstitial lung disease (SSc-ILD ...
Looking for online definition of usual interstitial pneumonia of Liebow in the Medical Dictionary? usual interstitial pneumonia of Liebow explanation free. What is usual interstitial pneumonia of Liebow? Meaning of usual interstitial pneumonia of Liebow medical term. What does usual interstitial pneumonia of Liebow mean?
Introduction. Lymphocytic interstitial pneumonia (LIP) is regarded as a preneoplastic disease that results from inflammatory pulmonary reaction to various external stimuli or systemic disease.1 LIP is characterized by a diffuse lymphocytic infiltrate with lymphoid hyperplasia around the enlarging airways. This may range from small benign lymphoid aggregates to high degree lymphoma in 5% of cases.1-3 Death results in approximately 33% to 50% of patients in nearly five years after the diagnosis.2. Acute cor pulmonale is a clinical syndrome characterized by signs of right heart failure (right ventricular hypertrophy) of sudden onset and results from the abrupt increase of pulmonary vascular resistance due to diseases that affect the function and/or the structure of the lung, of which pulmonary embolism is the most common cause.4. In Brazil, despite the availability of antiretroviral drugs in the public health system, the initiation of acquired immunodeficiency syndrome (AIDS) treatment is delayed.5 ...
Anti-MDA-5 antibody was first discovered in a Japanese population of amyopathic dermatomyositis patients in 2005. Autoantibodies were analysed from 298 patients with various connective tissue diseases, and anti-MDA-5 antibodies were detected in 8 of 42 patients with dermatomyositis. Those with anti-MDA-5 autoantibodies had significantly more rapidly progressive interstitial lung disease (ILD) when compared with patients without anti-MDA-5 autoantibodies.1. Another retrospective study found 10 out of 77 dermatomyositis patients were positive for the anti-MDA-5 antibody. This study found a characteristic cutaneous phenotype including skin ulceration, tender palmar papules or both. Hyperkeratosis of digital pulp, ulceration located on lateral nail folds, elbows, knees and Gottron papules were significantly associated with the disease. Patients with anti-MDA-5 antibodies also had an increased risk of hand swelling, arthritis/arthralgia and diffuse hair loss.2. Our patient did not present with ...
From BioPortfolio: Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest hig...
There are complex interactions between connective tissue disease (CTD) and interstitial lung disease (ILD), particularly in the PH patient. Clinicians that care for these patients will benefit from a deeper understanding of CTD and the ILD aspects of this diverse spectrum of disease. There are many clinical dilemmas to address and this course will focus on an approach to the evaluation and management of CTD-associated ILD.
What is CTD-ILD? Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a lung disease that may happen to some people with a connective tissue disease.
P1: Possibility when comparing CTD-ILD group and UCTD-ILD group. P2: Possibility when comparing CTD-ILD group and IPF group. P3: Possibility when comparing UCTD-ILD group and IPF group ...
Survival is linked to the histopathologic distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), the most commonly encountered fibrotic idiopathic interstitial pneumonia. We retrospectively compared the prognostic significance of histopathologic diagnos …
TY - JOUR. T1 - Tobacco smoke-related diffuse lung diseases. AU - Vassallo, Robert. AU - Ryu, Jay H.. PY - 2008/12. Y1 - 2008/12. N2 - Cigarette smoking has been associated with several diffuse lung diseases in which both bronchiolar and interstitial lung inflammation appear to result from chronic tobacco smoke inhalation. These diseases occur primarily in relatively young adult smokers and include desquamative interstitial pneumonia, respiratory bronchiolitis-associated interstitial lung disease, and pulmonary Langerhans cell histiocytosis. Although these diseases are associated with characteristic histopathologic and radiological features, there is significant overlap among these diseases, and some smokers may exhibit features indicative of the broad spectrum of smoking-related interstitial and bronchiolar lung injury patterns. Cigarette smoking has also been associated with acute eosinophilic pneumonia, and it increases the risk of developing other fibrotic interstitial lung diseases such as ...
2. Vassa Avaleha (herbs Jam) - 1 tablespoonful twice daily, after meals - (3 Pcs. x 1 month). 3. Kantkari Avaleha - 1 tablespoonful twice daily, after meals ( 3 Pc x 1 month ). 4. Aller-G Care Capsules - 2 capsules twice daily (2 Pc. x 1 month). 5. Tab. Amyron - 2 twice daily 6. Cap. Boswellia-Curcumin - 2 twice daily 7. Praanrakshak Churna - 1 teaspoonful twice daily or consume after boiling in water- take 1 tablespoonful of powder, boil in 400 ml water, untill it remains 50 ml. Filter it and consume lukewarm twice daily.Make fresh daily.. These are pure ayurvedic medicines for interstitial lung disease. The treatment is purely natural without causing any side effects. This Ayurvedic treatment of ILD can be continued along with any ongoing treatment. The herbal remedies for interstitial lung disease give results within few days of usage and should be continued for few months.. You can write at [email protected] for feedback and information about how you can get these remedies ...
Dr. Antin-Ozerkis received her Bachelors degree from Princeton University. She went on to complete her medical degree, residency, and fellowship in Pulmonary and Critical Care Medicine at the University of Pennsylvania, where she pursued advanced fellowship training in the evaluation and management of advanced lung disease and lung transplant patients. She came to Yale in 2006. Dr. Antin-Ozerkis is Medical Director of the Yale Interstitial Lung Disease Center of Excellence. Her specific area of clinical expertise is the diagnosis and treatment of interstitial lung diseases (ILD), with a focus on idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated interstitial lung disease (CTD-ILD). She leads a multidisciplinary group which meets weekly to review patient cases, offering consensus opinions on diagnosis and management. As part of a comprehensive approach to patient care, Yale ILD offers clinical drug trials for patients with IPF and other forms of pulmonary fibrosis. Dr. ...
Mutations in the surfactant protein C gene (SFTPC) result in interstitial lung disease (ILD). Our objective was to characterize clinical and genetic spectrum of ILD in Chinese children associated with SFTPC mutations. Six Chinese children with ILD heterozygous for SFTPC mutations were included. Candidate genes responsible for surfactant dysfunction were sequenced by next-generation sequencing. Subclones of SFTPC with novel mutations were generated and transiently transfected into A549 cells. The functional characterization of mutant surfactant protein C (SP-C) was evaluated by Western blotting and immunofluorescence. The age of onset ranged from 7 days to 15 months. All cases required supplemental oxygen. Failure to thrive (5/6) was the most significant extra-pulmonary manifestation. Hydroxychloroquine was given as the long-term treatment of lung disease in four patients and two of them responded well. Three mutations were identified in six patients: four with I73T, one with D105G, one with Y113H.
Bronchoalveolar lavage (BAL) has been crucial in elucidating the immune effector cells involved in the inflammatory processes in idiopathic interstitial pneumonias 1. Despite its value as a research tool, the diagnostic usefulness of BAL in idiopathic interstitial pneumonias is limited. An increase in neutrophils and/or eosinophils and/or lymphocytes may be seen. The idiopathic interstitial pneumonia with the worst prognosis is idiopathic pulmonary fibrosis (IPF) showing a histological pattern of usual interstitial pneumonia (UIP) 2. In IPF, historical data suggests that certain changes in BAL cell differentials may have prognostic importance; in some studies, patients with increased percentages of neutrophils or eosinophils (or both) had a worse prognosis, whereas BAL lymphocytosis has been associated with a greater responsiveness to corticosteroid therapy 3-6.. The most detailed data in that context have been published by Watters et al. 4. In their cohort, pretreatment BAL lymphocytosis was ...
Objective: To explore the correlations between miR-125b, miR-200c, and the severity of interstitial lung disease associated with dermatomyositis/polymyositis (DM/PM-ILD). Methods: 30 consecutive patients with DM/PM and 23 healthy controls were recruited into current study. Anti-JO-1, anti-SSA, muscle enzymes, the data of chest HRCT and pulmonary function test were collected. 9 consecutive DM/PM-ILD patients underwent bronchoalveolar lavage (BAL). TGF-β1 and surfactant protein D (SP-D) in BAL fluid (BALF) and plasma were detected by ELISA. miR-125b and miR-200c in PBMCs and bronchoalveolar cells were detected by QRT-PCR. All patients were classified into three groups: Mild or non-ILD group, moderate ILD group, and severe ILD group. The correlations between miRNAs and the severity of ILD, the lung damage markers, auto-antibodies, were analyzed. Results: The levels of miR-125b and miR-200c in bronchoalveolar cells were higher than in PBMCs, and the levels of TGF-β1 and SP-D were higher in BALF than in
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). However, its potential role in IPF pathogenesis remains unclear. In this study, we used ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to characterize lipid changes in plasma derived from IPF patients with stable and progressive disease. We further applied a data-independent acquisition (DIA) technique called SONAR, to improve the specificity of lipid identification. Statistical modelling showed variable discrimination between the stable and progressive subjects, revealing differences in the detection of triglycerides (TG) and phosphatidylcholines (PC) between progressors and stable IPF groups,
This multidisciplinary concensus was adopted in 2001 by both the American Thoracic Society (ATS) and the European Respiratory Society (ERS) in order to standardize classification of the idiopathic interstitial pneumonias.
We observed significant associations between 2 circulating markers of interstitial lung disease and subsequent lung cancer risk in a large cohort study, the PLCO Cancer Screening Trial. After adjustment for cigarette smoking, lung cancer risk was increased 1.9-fold during follow-up for those in the highest quartile of SP-D, and 1.6-fold for those in the highest quartile of KL-6, compared with people with the lowest levels of these markers.. These associations with lung cancer risk are biologically plausible because elevated circulating SP-D and KL-6 levels have been detected in patients with a number of pulmonary diseases, including idiopathic pulmonary fibrosis (15, 21), idiopathic pulmonary alveolar proteinosis (22), and acute respiratory distress syndrome (16, 23). Individuals with COPD also have elevated SP-D levels (17, 18). Both glycoproteins are produced by type II alveolar cells, which proliferate and replace type I alveolar cells during lung injury (27). Subsequently, the reparative ...
Respiratory Bronchiolitis-Associated Interstitial Lung Disease - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Definition of acute interstitial pneumonia. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
The aim of this study was to investigate HLA class II associations in polymyositis (PM) and dermatomyositis (DM), and to determine how these associations influence clinical and serological differences. DNA samples were obtained from 225 UK Caucasian idiopathic inflammatory myopathy patients (PM = 117, DM = 108) and compared with 537 randomly selected UK Caucasian controls. All cases had also been assessed for the presence of related malignancy and interstitial lung disease (ILD), and a number of myositis-specific/myositis-associated antibodies (MSAs/MAAs). Subjects were genotyped for HLA-DRB1, DQA1 and DQB1. HLA-DRB1*03, DQA1*05 and DQB1*02 were associated with an increased risk for both PM and DM. The HLA-DRB1*03-DQA1*05-DQB1*02 haplotype demonstrated strong association with ILD, irrespective of myositis subtype or presence of anti-aminoacyl-transfer RNA synthetase antibodies. The HLA-DRB1*07-DQA1*02-DQB1*02 haplotype was associated with risk for anti-Mi-2 antibodies, and discriminated PM from DM (odds
Actemra (tocilizumab) is a treatment by Genentech approved for the treatment of systemic sclerosis-associated interstitial lung disease.
A brief introduction to radiographs and chest CT scans for the diagnosis of cystic lung diseases.&nbsp; Lymphangioleiomyomatosis (LAM) is the focus &ndash; including diagnosis of the disease and its complications.&nbsp; Other cystic lung diseases such as Langerhans Histiocytosis, Birt-Hogg-Dube and Lymphocytic Interstitial Pneumonia (LIP) will also be mentioned.
TY - JOUR. T1 - Serum procalcitonin for differential diagnosis of acute exacerbation and bacterial pneumonia in patients with interstitial lung disease. AU - Sim, Jae Kyeom. AU - Oh, Jee Youn. AU - Lee, Eun Joo. AU - Hur, Gyu Young. AU - Lee, Seung Heon. AU - Lee, Sung Yong. AU - Lee, Sang Yeub. AU - Kim, Je Hyeong. AU - Shin, Chol. AU - Shim, Jae Jeong. AU - In, Kwang Ho. AU - Kang, Kyung Ho. AU - Min, Kyung Hoon. N1 - Funding Information: This study was supported by a grant from Korea University , Seoul, Korea ( K1326181 ). PY - 2016. Y1 - 2016. N2 - Background: Acute exacerbation and bacterial pneumonia are major life-threatening conditions in patients with interstitial lung disease (ILD). The rapid recognition of these 2 different conditions is important for their proper treatment. An elevated procalcitonin (PCT) level is commonly detected in patients with bacterial infections. This study assessed the usefulness of the serum PCT level as a biomarker for the differential diagnosis of acute ...
PubMed journal article: Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. Download Prime PubMed App to iPhone, iPad, or Android
Bronchial washings and biopsy negative. Final Diagnosis: Wedge biopsy, RLL: histological features of respiratory bronchiolitis; special stains negative for PCP Final Diagnosis Comment: Sections from both the right upper and lower lobes show c...
Drug-induced Hemorrhagic Disorder & Sputum Production Symptom Checker: Possible causes include Aspiration Pneumonia & Desquamative Interstitial Pneumonia & Respiratory Bronchiolitis Interstitial Lung Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
For Patients: Helpful Information For Patients, The CTD-ILD Program is an integrative, patient-oriented program, which affords patients with CTD-ILD the opportunity receive comprehensive and coordinated care by experts in CTD-ILD
Results: Between 2000 and 2009 a total of 554 patients were diagnosed with ILDs, in the course of 708 hospitalizations. The mean number of hospitalizations per patient was 1.3 (range 1-11). Admissions due to ILDs encompassed 3.5% of the total hospital admissions. A 20% increase in the annual rate of hospitalizations due to ILDs (from 10.7/100,000 between 2000- -2004 to 12.8/100,000 between 2005-2009) was recorded. Most frequent ILD diagnosis was interstitial pneumonia and fibrosis (J84) - 55.7% (including idiopathic pulmonary fibrosis [IPF] - J84.1-27.5%) and sarcoidosis (D86) - 25%. During the study period the increase in hospitalizations was observed in patients with sarcoidosis (+55%) and in the group of interstitial pneumonia and fibrosis (+39%), but the decrease (-38%) in the group of pneumoconiosis (J60-J68). Sex ratio (M/F) was 1.5/1 for all ILDs; ranging from 1.2/1 for D86 and J84 to 4.7/1 for radiotherapy and drug induced ILDs (J70) and 7.1/1 for J60-J68. Respiratory failure was found ...
The most common extra-articular manifestation of rheumatoid arthritis (RA) is interstitial lung disease (ILD). RA related ILD (RA-ILD) is associated with significant morbidity and mortality. The main objective of this study was to determine the correlation between the rheumatoid factor (RF) serotypes and the severity of RA-ILD based on computed tomography (CT) findings. We recruited a total of 100 RA patients who were tested for IgA RF, IgG RF and IgM RF and had high resolution CT chest performed. Seventy-two patients had ILD changes on HRCT of the chest and were included in this study. We found that the the CT scores for ground glass showed significant positive correlation with disease duration and IgA RF levels whereas the fibrosis scores had significant relationship with multiple clinical covariates i.e age, disease duration, IgA RF levels, IgG RF levels and anti-CCP levels. On multivariate analysis, only IgA levels remained significantly (p,0.05, standardized beta coefficient = 0.604) ...
JIPS Registry is a multi-site, non-interventional, prospective observation study of patients with newly diagnosed IIPs in Japan. At least 600 patients will be registered for 16 months at approximately 80 sites in Japan.. Primary research question is to determine the natural history of each category of IIPs at registration, patient background and diagnosis methods will be considered. Furthermore, the present treatment patterns and disease behavior (CT and forced vital capacity (FVC) changes, as well as changes in interstitial pneumonia markers, etc.) will also be investigated.. ...
Results The serum PGRN levels were significantly higher in the DM patients (median: 100 ng/ml) than in the PM patients (60.4 ng/ml, P=0.0028) and NHCs (48.3 ng/ml, P,0.0001). Of the total DM patients, the levels were significantly higher in DM with A/SIP than that in DM with CIP (P,0.0001) or without ILD (P=0.0002). Proportion of clinically amyopathic DM is higher in DM with A/SIP than in DM with CIP or without ILD (76.9%, 40%, and 5.9%, respectively). The serum PGRN levels correlated significantly with serum ferritin (rs=0.71, P=0.0001), LDH (rs=0.59, P=0.0003), and CRP (rs=0.57, P=0.0005) levels. They significantly decreased following successful treatment of DM (P=0.0313). Moreover, the cumulative survival rate for 6 months was significantly lower in the group with serum PGRN levels , or =200 ng/ml (60%) than that in the group with serum PGRN levels , 200 ng/ml (P=0.001).. ...
Interstitial lung diseases (ILDs) represent a heterogeneous group of clinical entities among which disease of unknown causes may mimic ILDs due to known causes [ 1 ]. Clinical, radiographic and histopathology presentation can largely overlap between different entities and a multidisciplinary approach is proven to be essential in composing the puzzle to reach the most likely clinical diagnosis in each single patients [ 2 ]. The defi nition of specifi c radiographic (on chest high-resolution computed tomography, HRCT) and histopathology (on lung surgical lung biopsy, SLB) patterns has provided a common terminology in the fi eld of ILDs in the tentative of classifying entities presenting with distinctive features. These patterns have been proposed in the classifi cation of idiopathic interstitial pneumonias (IIPs) [ 3 ], and then have been applied to describe ILDs due to secondary known causes, particularly those related to connective-tissue diseases. Among all these patterns, the usual ...
Free, official information about 2012 (and also 2013-2015) ICD-9-CM diagnosis code 516.34, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
Patients, Death, Disease, Treatment, Diagnosis, Sarcoidosis, Prednisone, Association, Biopsy, Gallium, Gold, Role, Technetium, Thallium, Cyclophosphamide, Idiopathic Interstitial Pneumonias, Interstitial Lung Disease, Interstitial Pneumonia, Interstitial Pneumonias, Lung
Although extra intestinal manifestations are relatively common (13-45%) in patients with IBD [2], pulmonary manifestations are considered rare [1-3]. Moreover, while there have been reported cases of pulmonary manifestations in pediatric CD [7-9], this is the first reported case of interstitial lung involvement in a child with UC. In comparison, Camus and coworkers have described a number of pulmonary manifestations in adult patients with UC, including bronchiolitis obliterans with organizing pneumonia, chronic bronchitis, bronchiectasis, bronchiolitis, serositis and interstitial lung disease. Most (, 60%) of the patients manifested pulmonary symptoms during periods of quiescent bowel disease, and there was no correlation between age at bowel disease onset, and either the time of onset of respiratory symptoms or the degree of respiratory involvement. Although 8 patients were diagnosed with UC in childhood, all developed respiratory symptoms during adulthood. Moreover, proctocolectomy was not ...
Welcome to the National Association for Continuing Education webcast from the NACE Emerging Challenges in Primary Care 2017 conference.. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia. IPF is associated with increased comorbidity, healthcare resource utilization, and direct medical costs. The disease has a poorer prognosis than other interstitial lung diseases, with a median survival of 3 years from diagnosis.. The critical role of the Primary Care Clinician revolves around recognizing patients at risk for IPF, ordering appropriate screening tests like a HRCT, and subsequent referral to specialty centers for evaluation and monitoring. This program incorporates video of real patients with IPF detailing their experiences with the disease and was recorded live with the permission ...
Details of the image Usual interstitial pneumonia in rheumatoid arthritis with possible follicular bronchiolitis Modality: X-ray (Frontal)
Idiopathic pulmonary fibrosis (IPF) is definitely a chronic lethal interstitial lung disease of unfamiliar etiology. that VCAM-1 can be a TGF-β1 reactive mediator that partakes in fibroblast proliferation in topics with IPF. mRNA inhibits fibroblasts proliferation and impairs cell routine development through depletion of particular signaling elements implicating in mobile proliferation. In aggregate these observations provide a foundation for further studies on the mechanistic role of VCAM-1 in IPF pathogenesis. Materials and Methods Materials VCAM1 antibody was obtained from Novus Biologicals (Littleton CO). Anti-Collagen type 1 antibody was from Rockland (Limerick PA). β -actin antibody was purchased from Sigma-Aldrich (St. Louis MO). The cyclin D1 cyclin D2 cyclin D3 cdk2 cdk4 and cdk6 antibodies were from Cell Signaling (Danvers MA). The anti- ERK1/2 phosphor-ERK1/2 p38 and phosphor-p38 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz CA). The miRNA mini Kit was from ...
MONDAY, March 4, 2019 (HealthDay News) -- While an unrestricted listing strategy does not seem to impact overall survival among patients with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) awaiting lung transplant, it may increase the number of transplants performed, according to a study published in the February issue of the Annals of the American Thoracic Society.. Michaela R. Anderson, M.D., from the Columbia University Medical Center in New York City, and colleagues assessed data from 12,155 adults with COPD or ILD listed for lung transplantation in the United States (May 4, 2005, to Dec. 31, 2014) to determine whether an unrestricted procedure preference was associated with improved overall outcomes.. The researchers found that an unrestricted procedure preference was associated with a 3 percent lower rate of the composite primary outcome (number of days between listing and death, removal from the list for clinical deterioration, or retransplantation) in ...
This office sees patients with lung and sleep related disorders. Diseases seen include asthma, COPD, emphysema, sarcoidosis, lung infections, undiagnosed cough, lung nodules and masses, interstitial lung disease patients, obstructive sleep apnea and other sleep related disorders. Patient with shortness of breath, cough and excessive sleepiness are welcomed. Patient can be referred by their physicians or self refer ...
The interstitial lung diseases of childhood, so called chILD, until fairly recently were classified based upon histologic appearance and clinical outcomes and although these metrics are still useful; identification of the genetic causes of many of these diseases is making classification more precise and helping to identify potential therapeutic targets. Moreover, in the case of surfactant metabolism disorders of the neonate and infant, what were once considered histologically distinctly disorders, e.g. pulmonary alveolar proteinosis (PAP), nonspecific interstitial pneumonitis, diffuse interstitial pneumonitis, and chronic pneumonitis of infancy are now recognized to have related underlying genetic mechanisms making it possible to identify some patients with these disorders by genetic testing rather than by lung biopsy [8].. Using PAP as an example, it is now recognized that the severe, neonatal form is caused by deficiency in the hydrophobic surfactant apoprotein (Sp)B. Abnormalities in the ...
PURPOSE: To achieve pathologic correlation in areas of ground-glass attenuation (GGA) in usual interstitialpneumonia(UIP) and, using serial thin-section CT, to observe changes in those lesions. MATERIALS AND METHODS:CT-pathologic correlation was performed at 20 sites of GGA in 18 patients with UIP. Two chest radiologistsassessed serial CT scans, focusing particularly on areas of GGA where open lung biopsy had been performed.Pathologic score of inflammation vs. fibrosis was recorded by two independent lung pathologists. RESULTS: Oninitial CT, GGA appeared as an isolated manifestation at one site, mixed with irregular lines at six, and mixedwith both irregular lines and bronchiectasis/bronchiolectasis at thirteen. Pathologically, those areascorresponded respectively to areas of active inflammation, dominant inflammation, and dominant fibrosis. Theextent of GGA seen on follow-up CT decreased when it was an isolated finding (n=1), and at four of six sites (67%)where it was associated with irregular ...
ISBN 978-0-8247-1992-0. Marvin I. Schwarz; Talmadge E. King (2010). Interstitial Lung Disease. PMPH-USA. p. 538. ISBN 978-1- ... On the Incidence of Rheumatic Diseases 1931 Sheldon Francis Dudley, On Lessons on Infectious Diseases in The Royal Navy 1932 ... Drug Abuse as a Communicable Disease 1972 A. Gerald Shaper, Cardiovascular Disease in the Tropics 1973 D.J. Bauer, Antiviral ... ISBN 978-1-317-31866-8. William Heaton Hamer (1906). The Milroy Lectures on Epidemic Disease in England: The Evidence of ...
Imaging of Interstitial Lung Disease. Clinics Chest Med, 2004;25:455-465. Craighead JE et al. Diseases Associated with Exposure ... Occupational Interstitial Lung Disease. Clinics Chest Med, 2004;25:467-478. Pipavath S and Godwin JD. ... The disease arises firstly through the deposition of silica or coal dust (or other dust) within the lung, and then through the ... The most notable indications are the fact that the disease tends to develop in the upper lobe of the lung - especially on the ...
"Interstitial lung disease in newborns". Seminars in Fetal and Neonatal Medicine. 22 (4): 227-233. doi:10.1016/j.siny.2017.03. ... congenital diffuse lung disease characterized by abnormal blood vessels in the lungs that cause highly elevated pulmonary blood ... Bilateral lung transplantation may be the definitive treatment. Epidemiology[edit]. ACD is a rare disease. As of 2011, about ... ACD is typically diagnosed by examination of lung tissue under a microscope, either from lung biopsy or an autopsy. The ...
Interstitial/. restrictive. (fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. ... Thillai, Muhunthan; Moller, David R.; Meyer, Keith C. (2017). Clinical Handbook of Interstitial Lung Disease. CRC Press. p. ... Asbestosis resembles many other diffuse interstitial lung diseases, including other pneumoconiosis. The differential diagnosis ... Figure B shows lungs with asbestos-related diseases, including pleural plaque, lung cancer, asbestosis, plaque on the diaphragm ...
A sarcoidosis-like lung disease called granulomatous-lymphocytic interstitial lung disease can be seen in patients with common ... Sarcoidosis of the lung is primarily an interstitial lung disease in which the inflammatory process involves the alveoli, small ... March 2008). "Sarcoidosis: Interstitial Lung Diseases: Merck Manual Home Edition". The Merck Manual Home Edition. Merck Sharp ... Sarcoidosis UK Information Hub Iannuzzi, M. C.; Sah, B. P. (March 2008). Sarcoidosis: Interstitial Lung Diseases. The Merck ...
Interstitial lung disease-like events[Note 27]. *Gastro-oesophageal reflux disease (GORD) ... Lung[edit]. In some kinds of lung cancer (with squamous-cell histology) sorafenib administered in addition to paclitaxel and ... "Addition of Sorafenib May Be Detrimental in Some Lung Cancer Patients". login.medscape.com.. ... hazard ratio for disease progression in the sorafenib group, 0.44; 95% confidence interval [CI], 0.35 to 0.55; P,0.01).[11] ...
Clinical Atlas of Interstitial Lung Disease. Springer. pp. 91-95. doi:10.1007/978-1-84628-326-0_16. ISBN 978-1-84628-320-8. ... The disease was first described in the medical literature in 1967 by R.D. Strand and colleagues in the New England Journal of ... The disease is rare, possibly because of the large quantity of spores that need to be inhaled for clinical effects to occur. ... In another instance, a teenager spent 18 days in a coma, had portions of his lung removed, and suffered severe liver damage. In ...
... interstitial lung diseases. Idiopathic pulmonary fibrosis (IPF), an interstitial lung disease of unknown cause, is most common ... eMedicine Specialties > Pulmonology > Interstitial Lung Diseases > Restrictive Lung Disease Archived 5 March 2010 at the ... Pulmonary fibrosis may be a secondary effect of other diseases. Most of these are classified as interstitial lung diseases. ... The Epidemiology of Interstitial Lung Diseases. Am J Respir Crit Care Med. Oct 1994;150(4):967-72. cited by Michaelson JE, ...
ISBN 978-3-540-77982-7. C.A.C. Pickering; L. Doyle; K.B. Carroll (1981). "4. Honeycomb lung". Interstitial Lung Disease. MTP ... signs in the mouth and the appearance of advanced gum disease. Features relating to lung and liver disease may occur. It is due ... There may be large lymph nodes and signs of lung and liver disease. Affected people may present with fever and weight loss. The ... The disease was once thought to be a lipid storage disease as the lesions have a high cholesterol content, but the blood ...
... interstitial lung disease Rare (. ...
... and coronavirus disease 2019 (COVID-19). Interstitial lung disease A549 cells Moore K (2018). Clinically oriented anatomy. ... Further changes in blood flow can lead to decline in lung function. Emphysema is another disease of the lungs, whereby the ... Diffuse alveolar damage can be a cause of acute respiratory distress syndrome(ARDS) a severe inflammatory disease of the lung. ... "British Lung Foundation". How Children's Lungs Grow. 16 September 2019. Retrieved 5 April 2020. "22.7 Embryonic Development of ...
Kojiro Kusanagi, 78, Japanese actor, interstitial lung disease. Berkeley Lent, 86, American judge on the Oregon Supreme Court, ... Raleigh Rhodes, 89, American World War II pilot, early leader of the Blue Angels, lung cancer. Jaroslav Skála, 91, Czech ... Stephen Fumio Hamao, 77, Japanese Roman Catholic cardinal, former bishop of Yokohama, lung cancer. Bobby Harrop, 71, English ... Motosuke Takahashi, 66, Japanese film director and storyboard artist, lung cancer. David G. P. Taylor, 74, British businessman ...
Collard, Harold R.; Richeldi, Luca (2017-02-18). Interstitial Lung Disease E-Book. Elsevier Health Sciences. p. 9. ISBN ... "PI3 Kinase Disease , NIH: National Institute of Allergy and Infectious Diseases". www.niaid.nih.gov. Retrieved 2017-06-10. " ... "PASLI disease , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases.info.nih.gov. Retrieved ... Activated PI3K delta syndrome is a primary immunodeficiency disease caused by activating gain of function mutations in the ...
"Diffuse idiopathic pulmonary neuroendocrine cell proliferation presenting as interstitial lung disease". Am J Surg Pathol. 19 ( ... The morbidity associated with DIPNECH is due to the associated obstructive lung disease. The lung disease tends to be slowly ... As the disease progresses, a mixed pattern of obstruction and restriction may develop. In general the obstructive lung disease ... Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a diffuse parenchymal lung disease which often ...
Additionally, interstitial lung disease is an adverse event of particular importance. mTORi-induced ILD often is asymptomatic ( ... mTOR inhibitor-induced interstitial lung disease in cancer patients: comprehensive review and a practical management algorithm ... This study enrolled patients being treated for HER2-amplified breast cancer, HER2-mutant non-small-cell lung cancer, and other ... for health and diseases". Drug Discovery Today. 12 (3-4): 112-24. doi:10.1016/j.drudis.2006.12.008. PMID 17275731.. ...
"Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases". European Respiratory Journal. 55 (3): ... In a small study comparing the lungs of patients who had died from COVID-19 to those that had died from influenza A pneumonia ( ... The degree of intussusceptive angiogenic features in the lungs from the Covid-19 patients were also found to be greater as the ... "Injury patterns in COVID-19 lungs". Panta Rhei Study Group. Retrieved 6 July 2020. Mentzer SJ, Konerding MA. Intussusceptive ...
... pulmonary fibrosis Before and after lung surgery It appears not to be harmful and may be helpful for interstitial lung disease ... It is a broad program and may benefit patients with lung diseases such as chronic obstructive pulmonary disease (COPD), ... "Pulmonary rehabilitation for interstitial lung disease". The Cochrane Database of Systematic Reviews. 10 (10): CD006322. doi: ... education about the patient's lung disease and how to manage it, nutrition counseling, and emotional support. Medications may ...
Interstitial lung disease is also common. Some individuals may not experience any obvious skin issues. All affected children ... protein and characterised by severe skin lesions and interstitial lung disease. The onset is in infancy. The skin lesions occur ... Chest X rays show sign consistent with interstitial lung disease.[citation needed] Bloods: Anemia, leukopenia, thrombocytosis, ... These mice, known as STING N153S mice, developed spontaneous lung disease and a severe immunodeficiency to a herpesviruses. ...
Interstitial lung disease. *Dermatology *Pemphigus vulgaris. *Contact dermatitis. *Endocrinology (usually at physiologic doses ... "Archives of Disease in Childhood. 101 (4): 365-70. doi:10.1136/archdischild-2015-309522. PMC 4819633. PMID 26768830.. ... "PLOS Neglected Tropical Diseases. 10 (7): e0004879. doi:10.1371/journal.pntd.0004879. PMC 4965027. PMID 27467600.. ... Topical formulations are also available for the skin, eyes (uveitis), lungs (asthma), nose (rhinitis), and bowels. ...
These include interstitial lung diseases, asthma, and gastroesophageal reflux disease. Initially, the latency period often ... "The lung disease he had was a consequence of injecting prescription drugs". Officials from the Chief Medical Examiner's office ... 11 lung illness to be honored" Archived September 14, 2008, at the Wayback Machine, The Record (Bergen County), September 11, ... Breton's autopsy found what he described as "unidentified foreign materials" in Zadroga's lungs, which were identified by the ...
... interstitial lung disease, including acute interstitial pneumonitis; thrombocytopenia; and peripheral neuropathy. Overall, ... The trial's primary endpoint was invasive disease-free survival (IDFS), defined as the time from the date of randomization to ... who have residual invasive disease after neoadjuvant taxane and trastuzumab-based treatment. Approval was based on KATHERINE ( ...
"Hydrogen Peroxide Inhalation Causing Interstitial Lung Disease". American Thoracic Society International Conference Meetings ... "Coronavirus Disease 2019 (COVID-19)". Centers for Disease Control and Prevention. February 11, 2020. Centers for Disease ... and subacute hydrogen peroxide inhalation use which lead to interstitial lung disease in the form of acute pneumonitis. ... Centers for Disease Control and Prevention (March 3, 2020). "Show Me the Science - When & How to Use Hand Sanitizer in ...
Pulmonary fibrosis and interstitial lung disease were observed in clinical trials. Panitumumab does not work in patients who ... Panitumumab was initially approved on September 27, 2006 for EGFR-expressing, metastatic CRC with disease progression on or ... "the treatment of EGFR-expressing metastatic colorectal cancer with disease progression" despite prior treatment. Panitumumab ...
In March 2020, it was approved for use in the United States to treat chronic fibrosing (scarring) interstitial lung diseases ( ... "FDA Approves First Treatment for Group of Progressive Interstitial Lung Diseases". U.S. Food and Drug Administration (FDA) ( ... The safety and effectiveness of nintedanib to treat chronic fibrosing interstitial lung diseases with a progressive phenotype ... including the associated interstitial lung disease) in July 2016 until 6 September 2019. The drug was granted priority review ...
Alzheimer's disease. Yukichi Amano, 80, Japanese columnist, interstitial lung disease. Leon Ashley, 77, American country music ... Deborah Turbeville, 81, American fashion photographer, lung cancer. Zuzzurro, 67, Italian actor and comedian, lung cancer. Ron ... Butch Warren, 74, American jazz bassist, lung cancer. Abdul Nasser Bani Hani, Jordanian politician, member of the House of ... Lou Reed, 71, American rock musician (The Velvet Underground) and songwriter ("Walk on the Wild Side"), liver disease. Nir ...
He died in 2005 of interstitial lung disease. Wilt, Alan F. (1975), The Atlantic Wall: Hitler's Defenses in the West, 1941-1944 ...
2005). "Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene". Eur. Respir. J. 24 (1): 30-9. doi: ... 2001). "A mutation in the surfactant protein C gene associated with familial interstitial lung disease". N. Engl. J. Med. 344 ( ... Humans and animals born lacking SP-C tend to develop progressive interstitial lung disease. Keller A, Eistetter HR, Voss T, ... Nogee LM (2004). "Alterations in SP-B and SP-C expression in neonatal lung disease". Annu. Rev. Physiol. 66: 601-23. doi: ...
... in undefined interstitial lung diseases: A retrospective study". Journal of Thoracic Disease. 5 (3): 283-8. doi:10.3978/j.issn. ... VATS can be useful for the diagnosis of undefined interstitial lung diseases. Thoracic surgery Cardiothoracic surgery Video- ... Thoracoscopy is a medical procedure involving internal examination, biopsy and/or resection/drainage of disease or masses ...
Interstitial lung disease. Mechanism of action[edit]. Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that ... February 2015). "Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and ... It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ... In March 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug.[13] Fall 2010 interim results ...
... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... The physical examination typically includes an assessment of volume state, blood pressure, heart, lungs, peripheral arteries, ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ...
Interstitial/. restrictive. (fibrosis). External agents/. occupational. lung disease. Pneumoconiosis (Asbestosis, Baritosis, ... Pleural disease. Pleuritis/pleurisy Pneumothorax/Hemopneumothorax (Tension pneumothorax). Pleural effusion: Hemothorax · ... Viral · Bacterial (Pneumococcal, Klebsiella) / Atypical bacterial (Mycoplasma, Legionnaires' disease, Chlamydiae) · Fungal ( ...
Diffuse parenchymal lung disease : ... 47 tables (ika-[Online-Ausg.] (na) edisyon). Basel: Karger. 2007. pa. 4. ISBN 978-3-8055 ... desquamative interstitial na pulmonya, respiratory bronchiolitis interstitial na sakit sa baga, at karaniwang interstitial na ... Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 44 (Suppl 2): S27-72. doi ... Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 53 (7): e25-76. doi: ...
85% of MGN cases are classified as primary membranous glomerulonephritis-that is to say, the cause of the disease is idiopathic ... tumors, frequently solid tumors of the lung and colon; hematological malignancies such as chronic lymphocytic leukemia are less ... A large part of this difficulty is due to a lack of ability to predict which people will progress to end-stage kidney disease, ... Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly people between ages of 30 ...
Interstitial/. restrictive. (fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. ... Chronic obstructive pulmonary disease. Other names. Chronic obstructive lung disease (COLD), chronic obstructive airway disease ... is not one single disease but an umbrella term used to describe chronic lung diseases that cause limitations in lung airflow. ... Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term breathing ...
呼吸性細支氣管炎伴間質性肺病(英语:Respiratory bronchiolitis interstitial lung disease) ... 職業性肺病(英语:Occupational lung disease). 肺塵病 石棉肺(英语:Asbestosis). 鋇塵肺(英语:Baritosis). 鐵釩土纖維化(英语:Bauxite fibrosis). 鈹肺病(英语:Berylliosis ... 阻塞性肺病(英语:obstructive lung disease). 急性. 急性支氣管炎. 慢性. 慢性阻塞性肺病 慢性支氣管
Mouth diseases include tongue diseases and salivary gland diseases. A common gum disease in the mouth is gingivitis which is ... Stimulation of the larynx by ingested matter produces a strong cough reflex in order to protect the lungs. ... It can also arise as a result of other gastrointestinal diseases such as coeliac disease. Coeliac disease is an autoimmune ... Crohn's disease is a common chronic inflammatory bowel disease (IBD), which can affect any part of the GI tract,[45] but it ...
Celiac disease. While it is caused by a permanent intolerance to gluten (present in wheat, rye, barley and oats), is not an ... "Celiac Disease". NIDDKD. June 2015. Archived from the original on 13 March 2016. Retrieved 17 March 2016.. ... "Celiac disease". World Gastroenterology Organisation Global Guidelines. July 2016. Archived from the original on 17 March 2017 ... National Institute of Allergy and Infectious Diseases (July 2012). "Food Allergy An Overview" (PDF). Archived from the original ...
Interstitial/. restrictive. (fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ...
Around 20-40% of polymyositis is positive for Jo-1 antibodies and most will have interstitial lung disease, HLA-DR3 and HLA- ... They are associated with central nervous system involvement, kidney disease, lung fibrosis and pericarditis in SLE, but they ... coeliac disease, autoimmune rheumatic diseases, cardiac neonatal lupus erythematosus and polymyositis.[18][19] During pregnancy ... increased disease duration, parotid gland enlargement, disease outside the glands and infiltration of glands by lymphocytes.[11 ...
... men after lung cancer. In the United Kingdom it is also the second most common cause of cancer death after lung cancer, where ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 2009-11-11. Retrieved ... Mouraviev V, Evans B, Polascik TJ (2006). "Salvage prostate cryoablation after primary interstitial brachytherapy failure: a ... Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race.[3] About 99% ...
It is used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease.[2] It is generally used for ... allergic and fibrotic lung reactions, lupus erythematosus-like reactions and rash (including urticaria), drug fever, ... interstitial nephritis and nephrotic syndrome, usually reversible on withdrawal. Very rarely, use of mesalazine has been ... including ulcerative colitis and Crohn's disease.[2] It is generally used for mildly to moderately severe disease.[2] It is ...
... into the interstitial fluid and two potassium ions into the cell from the interstitial fluid. This creates an ionic ... Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 81-137. doi: ... However, when the blood circulates through the lungs a pulmonary capillary endothelial enzyme called angiotensin-converting ... Many diseases are the result of a homeostatic failure. Almost any homeostatic component can malfunction either as a result of ...
Muscular and rheumatic diseases.. As per diclofenac. Salol. No data.. As per diclofenac.. PO, topical.. No data.. Lower urinary ... "Drugs Used In The Treatment Of Interstitial Cystitis". Drug Treatment in Urology. John Wiley & Sons, 2008. p. 65.. ... Severe pain (including labour pain); cough due to terminal lung cancer; angina; left ventricular failure.. As per codeine. ... Medical cannabis, or medical marijuana, refers to cannabis or its cannabinoids used to treat disease or improve symptoms.[22][ ...
ಜಾರ್ವಿಸ್ ಡಿ, ಬುರನಿ ಪಿ (೧೯೯೭) ಎಪಿಡೊಮಾಲಾಜಿ ಆಫ್ ಆಟೊಪಿ and atopic disease In: Kay AB (ed) Allergy and allergic diseases, vol ೨. ... Henoch-Schönlein purpura · Hypersensitivity vasculitis · Reactive arthritis · Farmer's lung · Post-streptococcal ... Diabetes mellitus type 1 · Hashimoto's thyroiditis · Guillain-Barré syndrome · Multiple sclerosis · Coeliac disease · Giant- ... Kay AB (2000). "Overview of 'allergy and allergic diseases: with a view to the future'". Br. Med. Bull. 56 (4): 843-64. doi: ...
... diseases interfering in lung function resulting in a ventilation-perfusion mismatch, such as a pulmonary embolus, or ... increasing their capability of carrying fluid away from the interstitial spaces perhaps as much as 10-fold. Therefore, in ... Because the lungs develop late in pregnancy, premature infants frequently possess underdeveloped lungs. To improve lung ... Diseases such as peripheral vascular disease can also result in local hypoxia. For this reason, symptoms are worse when a limb ...
... interstitial lung disease (e.g., bleomycin) and occasionally secondary neoplasm (e.g., MOPP therapy for Hodgkin's disease). ... A disease resulting from aggressive chemotherapy". Diseases of the Colon and Rectum. 32 (3): 206-9. PMID 2920627. doi:10.1007/ ... hereditary disease, kidney dysfunction, nutritional deficiencies or anemia of chronic disease. Treatments to mitigate anemia ... The term was coined in the early 1900s by Paul Ehrlich as meaning any use of chemicals to treat any disease (chemo- + -therapy ...
呼吸性細支氣管炎伴間質性肺病(英語:Respiratory bronchiolitis interstitial lung disease) ... 職業性肺病(英語:Occupational lung disease). 肺塵病 石棉肺. 鋇塵肺(英語:Baritosis). 鐵釩土纖維化(英語:Bauxite fibrosis). 鈹肺病(英語:Berylliosis). 類風濕塵肺綜合症(英語: ... 阻塞性肺病(英語:obstructive lung disease). 急性. 急性支氣管炎. 慢性. 慢性阻塞性肺
Hypersensitivity and autoimmune diseases. Type I/allergy/atopy. (IgE). Foreign. *Atopic eczema ...
Interstitial/. restrictive. (fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... Global Initiative for Chronic Obstructive Lung Disease. pp. 9-17.. *^ a b Reilly, John J.; Silverman, Edwin K.; Shapiro, Steven ... Craven, V; Everard, ML (January 2013). "Protracted bacterial bronchitis: reinventing an old disease". Archives of Disease in ...
Interstitial/. restrictive. (fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... "Coronavirus Disease 2019 (COVID-19) Symptoms". Centers for Disease Control and Prevention. United States. 10 February 2020. ... "Coronavirus Disease 2019 (COVID-19)". Centers for Disease Control and Prevention (CDC). 15 February 2020. Archived from the ...
Disruption and disease[edit]. Because the glycocalyx is so prominent throughout the cardiovascular system, disruption to this ... Another protective function throughout the cardiovascular system is its ability to affect the filtration of interstitial fluid ... Streptococcus pneumoniae attaches itself to either lung cells, prokaryotes, or other bacteria which can fuse their glycocalices ... The enzymes and proteins listed above serve to reinforce the glycocalyx barrier against vascular and other diseases. Another ...
... can be used for detecting both acute and chronic changes in the lung parenchyma, that is, the internals of the lungs. ... It has more recently been used for preventive medicine or screening for disease, for example CT colonography for people with a ... For evaluation of chronic interstitial processes (emphysema, fibrosis, and so forth), thin sections with high spatial frequency ... LungsEdit. High-resolution computed tomographs of a normal thorax, taken in the axial, coronal and sagittal planes, ...
"Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International ... Laser-induced interstitial thermotherapy (LITT), or interstitial laser photocoagulation, uses lasers to treat some cancers ... Autoimmune diseases. There is an association between celiac disease and an increased risk of all cancers. People with untreated ... "the disease that cannot be cured".[191] This deep belief that cancer is necessarily a difficult and usually deadly disease is ...
Lung agenesis heart defect thumb anomalies. *Lung herniation congenital defect of sternem ... Megalocytic Interstitial Nephritis. *Mehes syndrome. *Mehta Lewis Patton syndrome. *Meier Blumberg Imahorn syndrome ... Wikipedia:WikiProject Missing encyclopedic articles/Missing diseases/7. From Wikipedia, the free encyclopedia ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Wikipedia:WikiProject_Missing_encyclopedic_articles/Missing_diseases ...
"Diseases and conditions index - hypotension". National Heart Lung and Blood Institute. September 2008. Retrieved 2008-09-16.. ... Increased blood pressure in the capillaries of the lung causes pulmonary hypertension, leading to interstitial edema if the ... What Is Pulmonary Hypertension? From Diseases and Conditions Index (DCI). National Heart, Lung, and Blood Institute. Last ... It can be useful in the differentiation of different forms of heart and lung disease. ...
Generation of interstitial fluid is regulated by the forces of the Starling equation.[8] Hydrostatic pressure within blood ... Kumar; Abbas; Fausto (1999). Pathologic Basis of Disease (7th ed.). Elsevier Saunders. p. 122. ISBN 0-7216-0187-1.. ... Pulmonary edema occurs when the pressure in blood vessels in the lung is raised because of obstruction to the removal of blood ... It can be caused by systemic diseases, pregnancy in some women, either directly or as a result of heart failure, or local ...
Asymptomatic lung infection is common, with fewer than 5% of infected individuals developing clinical disease.[6] Two ... whereas in the chronic form plain X-rays may show interstitial and alveolar infiltrates in the central and lower lung fields.[ ... Lung involvement subsequently occurs after a dormant phase, manifesting in upper respiratory tract symptoms, and lung ... In the juvenile form, lung abnormalities are shown in high-resolution CT scans of the lungs, ...
Interstitial lung disease. *Eosinophilic pneumonia. *Hypertension. *Suicidal behaviour & thoughts. *Serotonin syndrome. ...
... usual interstitial fibrosis, connective tissue-related lung disease ... This clinic focuses on the diagnosis and treatment of a wide variety of interstitial lung diseases including pulmonary fibrosis ... connective tissue-related lung disease, rheumatoid lung, scleroderma lung, systemic lupus erythematosis related lung disease, ... Interstitial Lung Disease Program Appointment Line: 503 494-1620. This clinic focuses on the diagnosis and treatment of a wide ...
Interstitial lung diseases are a group of diseases that inflame or scar the lungs. Breathing in particles (asbestosis, ... Interstitial lung disease (Medical Encyclopedia) Also in Spanish * Interstitial lung disease - adults - discharge (Medical ... Interstitial Lung Disease (Mayo Foundation for Medical Education and Research) * Interstitial Lung Disease: Overview (National ... Article: Dermatomyositis-related interstitial lung disease mimicking COVID-19 pneumonia. * Interstitial Lung Diseases -- see ...
... is a group of lung disorders in which the lung tissues become inflamed and then damaged. ... Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become inflamed and then damaged. ... People who are heavily exposed to known causes of lung disease in the workplace are usually routinely screened for lung disease ... In people with interstitial lung disease, this tissue becomes stiff or scarred, and the air sacs are not able to expand as much ...
Childhood interstitial lung disease (chILD) is a rare disorder that affects babies, children, and teens. Get an overview of ... Childrens Interstitial Lung Disease Foundation: "What Is chILD?". Boston Childrens Hospital: "Interstitial lung disease ... Childhood interstitial lung disease, known as "chILD," is a group of rare lung conditions that affect babies, kids, and teens. ... What Is Childhood Interstitial Lung Disease? Medically Reviewed by Dan Brennan, MD on August 21, 2020 In this Article * Causes ...
... latest diagnostic and therapeutic options for patients with the roughly 160 disorders categorized as interstitial lung diseases ... Interstitial Lung Disease Program. The Interstitial Lung Disease Program provides the latest diagnostic and therapeutic options ... Our Interstitial Lung Disease Program specializes in diagnosing and treating the full spectrum of interstitial lung diseases, ... You can search by disease, by keyword or by location.. We also understand that life with interstitial lung disease can be ...
... a group of diseases that make it difficult to get enough oxygen. Included is detail on types and complications. ... Interstitial lung disease may lead to cor pulmonale when the right ventricle has to pump harder to move blood through the lungs ... Interstitial lung disease is the name given to a group of conditions that cause inflammation and scar tissue in the lungs, ... The outlook for interstitial lung disease is different for everyone. It is a progressive disease, and there is currently no ...
... interstitial pneumonitis, black lung, Farmers lung, mold, grasses, fumes, and autoimmune diseases. The most common symptoms ... Treatment and prognosis depends upon the type of lung disease. ... is the name for a group of diseases that affect the lungs, for ... lungs a-z list / interstitial lung disease (interstitial pneumonia) center / interstitial lung disease (interstitial pneumonia ... Interstitial Lung Disease (Interstitial Pneumonitis). *Interstitial lung disease definition and facts. *What is interstitial ...
Interstitial Lung Disease News and Research. RSS Interstitial lung disease (ILD) is a broad group of lung diseases comprising ... Patients with interstitial lung disease-a group of disorders causing progressive scarring of lung tissue-are often prescribed ... A holistic approach key to minimize treatment complexity in patients with interstitial lung disease ... capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic ...
National Jewish Health is home to the worlds most respected interstitial lung disease (ILD) experts who conduct both industry- ... Interstitial Lung Disease Areas of Interest. *Translational studies into the mechanisms that lead to the development of ... Interstitial Lung Disease Animal Models. National Jewish investigators use several animal models to study aspects of the ... As one of the largest interstitial lung disease referral centers in the United States, we have access to patients, biological ...
... is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. ... Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by ... Pneumonia Fibrosis Hypersensitivity Pneumonitis Hypoxia Idiopathic Interstitial Lung Diseases Interstitial Lung Disease (ILD) ... Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease ...
... progressive lung can cause permanent breathing problems. Learn the causes, including many toxins in the environment. ... Management of interstitial lung disease associated with connective tissue disease. BMJ. 2016;352:h6819. ... Diagnostic yield and postoperative mortality associated with surgical lung biopsy for evaluation of interstitial lung diseases ... Patholody: Malignant and interstitial lung diseases. In: Murray and Nadels Textbook of Respiratory Medicine. 6th ed. ...
Learn how doctors test for and diagnose interstitial lung disease. ... Interstitial lung disease is a condition that causes inflammation and thickening of the lungs. This can make it hard to breathe ... Interstitial lung disease in children: What you need to know Interstitial lung disease is a condition that causes scarring in ... Interstitial lung disease in children: Symptoms Interstitial lung disease is a condition that causes inflammation and ...
Besides chronic obstructive pulmonary disease, pulmonary emphysema, and lung cancer, this group of diseases includes smoking- ... Inhalation of tobacco smoke is a risk factor for various diseases of the lungs and respiratory tract. ... and lung cancer, this group of diseases includes smoking-related interstitial lung disease (SR-ILD). ... The term interstitial lung disease (ILD) is used for a category of diseases characterized by damage to the pulmonary ...
How Interstitial Lung Disease (ILD) is treated through medications, oxygen therapy, pulmonary rehab, and in extreme cases, lung ... If this happens, lung transplantation may be an option for you. Lung transplant surgery replaces one or two diseased lungs with ... Lung transplantation is only performed at specialty medical centers. Your health care team may determine that lung transplant ... Link Between Reflux & Pulmonary Disease Help researchers predict which pulmonary diseases are predisposed to reflux. Our ...
... , Churg-Strauss Syndrome, Langerhans Cell Granulomatosis, Sarcoidosis, Granulomatosis with ... Interstitial Lung Disease is a chapter in the book, Pulmonology, containing the following 6 pages: ...
Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD).. ODwyer DN1, Armstrong ME, Cooke G, Dodd JD, Veale DJ, ... Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has ... pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary ... RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this ...
New data confirm a risk for interstitial lung disease in women with HER2-positive metastatic breast cancer receiving the ... NEW YORK (Reuters Health) - New data confirm a risk for interstitial lung disease (ILD) in women with HER2-positive metastatic ... And amongst the risks is that of interstitial lung disease, which was identified early on as a potentially clinically ... For You News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point ...
... progressive lung can cause permanent breathing problems. Learn the causes, including many toxins in the environment. ... Lung nodule, Pneumonitis, Chronic cough, Lung mass, Lung cancer, Interstitial lung disease ... Lung mass, Pleural disease, Pleural effusion, Lung tumor, Interstitial lung disease ... See a list of publications by Mayo Clinic doctors on interstitial lung diseases on PubMed, a service of the National Library of ...
... has become a standard diagnostic procedure for the majority of patients with interstitial disease. The technique is safe, ... Bronchoalveolar lavage in interstitial lung disease Curr Opin Pulm Med. 2001 Sep;7(5):255-61. doi: 10.1097/00063198-200109000- ... Recent research focused on the pathogenesis of various types of interstitial lung disorders. In this regard, BAL findings ... Bronchoalveolar lavage (BAL) has become a standard diagnostic procedure for the majority of patients with interstitial disease ...
ILD is actually a broad category of lung diseases that affect the tissue in the lungs around the air sacs and blood vessels. ... What Is Interstitial Lung Disease (ILD)?. By Maria M. Meyer and Paula Derr, with Mary Gilmartin, Contributing writers ... ILD is actually a broad category of lung diseases that affect the tissue in the lungs around the air sacs and blood vessels. ... What Is Chronic Lung Disease? When a Cough Isnt "Just a Cough" ... These parts of the lung become inflamed and/or scarred, which ...
Interstitial Lung Disease. Interstitial lung disease is a term that encompasses several diseases, but the common thread between ... The diagnosis of interstitial lung disease can often be difficult because the symptoms are very similar to other lung ... Interstitial lung disease affects bronchioles, which are the small airways in the lungs. These bronchioles develop clusters of ... But x-rays alone cannot detect interstitial lung disease. CT scans show highly detailed images of the lungs through ...
P275 Patient understanding, expectations and experiences of an interstitial lung disease specialist centre M Lee, M Bennett, C ... P280 Pulmonary rehabilitation (PR) for interstitial lung disease (ILD). do patients perceptions match functional outcomes? L ... P268 Is bronchiectasis severity influenced by aetiology or co-morbid airways disease? TM Quinn, AT Hill ... P272 Epidemiology of idiopathic pulmonary fibrosis in the uk: findings from the british lung foundations respiratory health ...
P175 Single centre experience of the real-life impact of pirfenidone on lung function in patients with idiopathic pulmonary ... P167 Does antifibrotic treatment outcomes differ in usual interstitial pneumonia based on HRCT criteria established by ATS/ERS/ ...
Lung Disease Program at Inova Fairfax Medical Campus provides comprehensive care for the entire spectrum of interstitial lung ... Lung Disease Program at Inova Fairfax Medical Campus provides comprehensive care for the entire spectrum of interstitial lung ... diseases, from mild to advanced-stage diseases requiring lung transplantation - all in a single center. ... diseases, from mild to advanced-stage diseases requiring lung transplantation - all in a single center. ...
Most of those disorders cause progressive scarring of the lung tissue that eventually affects your ability to breathe and get ... Doctors can pinpoint why some cases of interstitial lung disease occur, but many have no known cause. In all cases, lung ... Medications occasionally can slow the damage of interstitial lung disease, but many people never regain full use of their lungs ... Despite the wide variety of disorders classified as interstitial lung disease, the signs and symptoms are often similar, ...
Quantitative analysis of texture patterns on CT exams in interstitial lung disease patients can yield better survival ... Usual interstitial pneumonia tends to have a worse prognosis than non-UIP patterns of interstitial lung disease. The ... non-UIP patterns of interstitial lung diseases such as chronic hypersensitivity pneumonitis or non-specific interstitial ... CT textures predict interstitial lung disease survival. By Erik L. Ridley, AuntMinnie staff writer. July 23, 2020 -- ...
HealingWell.com Forum , Diseases & Conditions , Lupus , interstitial lung disease Select A Location. ****** Top of the Forum ... I, too, have been diagnosed with ILD...anyway my therapist told me that you can strengthen your lungs with one step at a time ... was told by pulmanolgist this week should have new lung but am too of a risk -heart too. hospital university of penn said ...
UC San Diego Healths advanced lung disease program offers treatment for interstition pulmonary fibrosis, also known as ... Home / Medical Services / Pulmonary & Critical Care Medicine / Advanced Lung Disease / Interstitial Lung Disease ... Interstitial lung disease (ILD) is a term that includes a variety of chronic lung disorders, including pulmonary fibrosis. In ... This scarring can cause the lung to become stiff and cause shortness of breath and interfere with lung function. ...
Program is dedicated to improving the lives of patients with interstitial lung disease, or ILD. Find out more. ... Interstitial Lung Disease Research UCSFs interstitial lung disease researchers investigate how lung tissue scarring develops ... The UCSF Interstitial Lung Disease (ILD) Program is dedicated to improving the lives of patients with interstitial lung disease ... Many studies have shown a link between GERD & lung disease, including interstitial lung disease (ILD). The reason for this ...
... www.merckmanuals.com/professional/pulmonary-disorders/interstitial-lung-diseases/overview-of-interstitial-lung-disease. Updated ... Interstitial lung disease (ILD) is a group of disorders that leads to scarring, called fibrosis, in the lung tissue. It affects ... Interstitial lung disease (ILD) is a group of disorders that leads to scarring, called fibrosis, in the lung tissue. It affects ... Interstitial lung disease. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T900225/Interstitial- ...
  • This category includes cryptogenic organizing pneumonia, acute interstitial pneumonia, nonspecific interstitial pneumonia, desquamative interstitial pneumonia, and lymphocytic interstitial pneumonia. (webmd.com)
  • Interstitial lung disease includes types such as interstitial pneumonia, idiopathic pulmonary fibrosis, and sarcoidosis. (medicalnewstoday.com)
  • Interstitial lung disease that can resemble pneumonia without an infection being present. (medicalnewstoday.com)
  • Several terms related to interstitial lung disease have been used to describe this condition, including 'interstitial pneumonia . (medicinenet.com)
  • However, since ' pneumonia ' is usually associated with an infection, some doctors choose to use the term 'interstitial pneumonitis' to refer to inflammation in the interstitial space since many of the causes of this inflammation are not infections. (medicinenet.com)
  • Smoking is also a risk factor for combined pulmonary fibrosis and emphysema (CPFE), rheumatoid-arthritis associated interstitial lung disease (RA-ILD), pulmonary alveolar proteinosis (PAP), acute eosinophilic pneumonia (AEP), and diffuse alveolar hemorrhage (DAH) in Goodpasture syndrome. (aerzteblatt.de)
  • Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). (nih.gov)
  • P167 Does antifibrotic treatment outcomes differ in usual interstitial pneumonia based on HRCT criteria established by ATS/ERS/JRS/ALAT in 2011? (bmj.com)
  • July 23, 2020 -- Quantitative analysis of texture patterns on CT exams in interstitial lung disease patients can yield better survival predictions than a radiologist's classification of usual interstitial pneumonia (UIP) versus non-UIP, according to research presented at last week's virtual ECR. (auntminnie.com)
  • Usual interstitial pneumonia tends to have a worse prognosis than non-UIP patterns of interstitial lung disease. (auntminnie.com)
  • On the other hand, non-UIP patterns of interstitial lung diseases such as chronic hypersensitivity pneumonitis or non-specific interstitial pneumonia also have distinct CT features. (auntminnie.com)
  • Rheumatoid Lung - I lost my middle lung love to Organized Pneumonia. (drugs.com)
  • 32. Gastroesophageal Reflux and Interstitial Pneumonia. (routledge.com)
  • for example, fibrosis in chronic eosinophilic pneumonia (CEP) and in BOOP, interstitial spread of Langerhans cell histiocytosis (LCH), and progression of desquamative interstitial pneumonia (DIP) to a picture of fibrotic nonspecific interstitial pneumonia (NSIP). (ecampus.com)
  • She was first diagnosed as having pneumonia, but after seeing her again she still had a fog over her lungs. (thebody.com)
  • I am very concerned because the Cat Scan results are also talking about sarcoidosis,pneumoconiosis,idiopathic pulmonary fibrosis, extrinsic allergic alveolitis and possibly interstitial pneumonia. (thebody.com)
  • ILDs include forms of pulmonary fibrosis and interstitial pneumonia, as well as ILDs associated with connective tissue diseases, tobacco use, and exposure to environmental and occupational toxins. (clevelandclinic.org)
  • Idiopathic interstitial pneumonia is the term given to ILDs with an unknown cause. (wikipedia.org)
  • This last group of patients has recently been defined as interstitial pneumonia with autoimmune features (IPAF). (aruplab.com)
  • Connective Tissue ILD, Chronic Hypersensitivity Pneumonitis, familial ILD and smoking-related ILD, and non-specific interstitial pneumonia are reviewed. (elsevier.com)
  • Several histopathological patterns are seen, including nonspecific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP), acute interstitial pneumonia (AIP), cryptogenic organizing pneumonia (COP), diffuse alveolar damage (DAD), and lymphocytic interstitial pneumonia (LIP). (oncologynurseadvisor.com)
  • Interstitial Lung Disease (ILD), also referred to as pulmonary fibrosis or interstitial pneumonia, comprises a group of conditions characterized by inflammation and scarring around the tiny air sacs (alveoli) in the lungs. (brighamandwomens.org)
  • The condition involves a distinct type of chronic fibrosing interstitial pneumonia of unknown cause. (advanceweb.com)
  • It's diagnosed via a number of findings, such as a surgical biopsy showing a "usual interstitial pneumonia" pattern, pulmonary function studies generally show restriction, with reduced total lung capacity or reduced vital capacity. (advanceweb.com)
  • NSIP is also called nonspecific interstitial pneumonia, which is currently indexed to code 516.8, Other specified alveolar and parietoalveolar pneumonopathies. (advanceweb.com)
  • LIP may also be known as lymphoid interstitial pneumonia and is characterized by the infiltration of the pulmonary interstitium (the tissue and space around the air sacs of the lungs) with lymphocytes and plasma cells. (advanceweb.com)
  • ILD can be confirmed by patterns of fibrosis on CT scans and after lung biopsies, as well as history of pneumonia for patients. (ajmc.com)
  • Thus, they narrowed their focus to therapeutic strategies for ILD in the context of systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), primary Sjogren syndrome (pSS), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD) and undifferentiated connective tissue disease (UCTD), and interstitial pneumonia with autoimmune features (IPAF). (ajmc.com)
  • idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP), acute interstitial pneumonia (AIP), respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), desquamative interstitial pneumonia (DIP), and lymphoid interstitial pneumonia (LIP). (koreamed.org)
  • Usual interstitial pneumonia- pattern fibrosis in surgical lung biopsies. (bmj.com)
  • Idiopathic interstitial pneumonias comprise the following disease entities, listed in decreasing order of frequency: Idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP), acute interstitial pneumonia (AIP), respiratory bronchiolitis-associated ILD (RB-ILD), desquamative interstitial pneumonia (DIP) and lymphoid interstitial pneumonia (LIP). (appliedradiology.com)
  • Various drugs can lead to virtually all histopathological patterns of interstitial pneumonia, depending on the mechanism of injury and healing. (appliedradiology.com)
  • Interstitial lung disease of unknown cause is predominated by idiopathic pulmonary fibrosis, a specific and progressive fibrotic lung disease, followed by the idiopathic interstitial pneumonias, such as nonspecific interstitial pneumonia (NSIP), and sarcoidosis. (omicsonline.org)
  • Interstitial lung disease, pulmonary vascular disease, aspiration pneumonia and pleurisy are common among which Interstitial Lung Disease is most common with an usual Interstitial Pneumonia (UIP) or Non-Specific Interstitial Pneumonia Pattern (NSIP). (thefreelibrary.com)
  • High Resolution Computed Tomography [HRCT] was suggestive of Usual Interstitial Pneumonia (UIP) pattern [Fig. 2, 3]. (thefreelibrary.com)
  • This clinic focuses on the diagnosis and treatment of a wide variety of interstitial lung diseases including pulmonary fibrosis, usual interstitial fibrosis, connective tissue-related lung disease, rheumatoid lung, scleroderma lung, systemic lupus erythematosis related lung disease, sarcoidosis, bronchiolitis obliterans, BOOP, and hypersensitivity pneumonitis. (ohsu.edu)
  • Idiopathic pulmonary fibrosis (IPF) is the most common disease of this type. (medlineplus.gov)
  • The Interstitial Lung Disease Program provides the latest diagnostic and therapeutic options for patients with the roughly 160 disorders categorized as interstitial lung diseases, also known as pulmonary fibrosis. (massgeneral.org)
  • Interstitial fibrosis' is the term used to refer to the scarring of the lungs that can result from prolonged interstitial inflammation. (medicinenet.com)
  • An international research team led by members of the University of Colorado School of Medicine faculty has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. (news-medical.net)
  • Veracyte, Inc. announced the presentation of data demonstrating that the Envisia Genomic Classifier can help physicians more confidently diagnose interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), without the need for surgery. (news-medical.net)
  • With support from the National Institutes of Health, investigators at National Jewish Health conduct extensive basic research into the mechanisms involved in the development and resolution of lung inflammation and fibrosis. (nationaljewish.org)
  • National Jewish investigators use several animal models to study aspects of the development and resolution of pulmonary fibrosis based on well-characterized experimental endpoints that include lung mechanics, histology, fluorescence imaging and biochemical assays. (nationaljewish.org)
  • Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. (springer.com)
  • In idiopathic pulmonary fibrosis (IPF), the antifibrotic drugs pirfenidone and nintedanib can delay disease progression. (aerzteblatt.de)
  • Interstitial lung disease (ILD) is a term that includes a variety of chronic lung disorders, including pulmonary fibrosis. (ucsd.edu)
  • Interstitial lung disease (ILD) is a group of disorders that leads to scarring, called fibrosis, in the lung tissue. (denverhealth.org)
  • Over time, the excess tissue building leads to fibrosis in the lungs. (denverhealth.org)
  • The fibrosis makes it difficult for oxygen to pass from the lung tissue to the blood vessels in the lungs. (denverhealth.org)
  • They sometimes cause fibrosis, or scarring, of the lungs. (sutterhealth.org)
  • Cigarette smoking, which is a main cause of idiopathic pulmonary fibrosis - a disease characterized by scarring in the lung tissue and shortness of breath. (sutterhealth.org)
  • We treat other interstitial diseases, particularly idiopathic pulmonary fibrosis, with medications such as pirfenidone or nintedanib. (sutterhealth.org)
  • [ 11 ] A diffuse interstitial and alveolar fibrosis may appear with variable fibrous thickening of small pulmonary vessels. (medscape.com)
  • In some cases, chronic interstitial fibrosis is noted. (medscape.com)
  • The most common interstitial pathologic pattern in patients with RA is diffuse fibrosis with inflammation. (medscape.com)
  • Interstitial lung diseases (ILDs) affect mainly the lung tissue (parenchyma) and include idiopathic pulmonary fibrosis, asbestosis, sarcoidosis, connective tissue disease related lung diseases and hypersensitivity pneumonitis as well as rarer interstitial lung diseases including LAM. (nuh.nhs.uk)
  • Experts consider idiopathic pulmonary fibrosis (IPF) one of the most dangerous of all interstitial lung diseases. (uhhospitals.org)
  • So, as with any interstitial lung disease, the sooner patients start treatment for idiopathic pulmonary fibrosis, the better. (uhhospitals.org)
  • Idiopathic pulmonary fibrosis (IPF) is a progressive disease isolated to the lungs. (clevelandclinic.org)
  • Idiopathic pulmonary fibrosis is interstitial lung disease for which no obvious cause can be identified (idiopathic) and is associated with typical findings both radiographic (basal and pleural-based fibrosis with honeycombing) and pathologic (temporally and spatially heterogeneous fibrosis, histopathologic honeycombing, and fibroblastic foci). (wikipedia.org)
  • A large group of lung diseases, ILD leads to scarring in your lungs (sometimes called pulmonary fibrosis). (uvahealth.com)
  • 4 In this study, the most prevalent ILD included pulmonary fibrosis, occupational-and environmental-associated disease, connective tissue disease-associated ILD, and sarcoidosis. (aruplab.com)
  • As a result of this a granulomatous interstitial fibrosis can develop, which has also been described as pulmonary talcosis. (scirp.org)
  • The Interstitial Lung Disease Center, a Pulmonary Fibrosis Foundation Care Center site , is an integrated, multidisciplinary regional referral center that provides comprehensive state-of-the-art evaluation and treatment of patients with interstitial lung disease (ILD). (uclahealth.org)
  • When inflammation is untreated for too long, it can result in pulmonary fibrosis, in which the lungs are scarred causing serious breathing problems. (myositis.org)
  • Interstitial lung diseases may also be referred to as interstitial pulmonary fibrosis or pulmonary fibrosis. (targetwoman.com)
  • If the cause is not determined, then such disorders without clearly known cause are grouped under idiopathic pulmonary fibrosis or idiopathic interstitial lung disease. (targetwoman.com)
  • Depending on your specific lung disease, its stage, your age and a variety of other factors, your physician may prescribe therapies to reduce fibrosis, modulate the immune system or treat pulmonary hypertension. (brighamandwomens.org)
  • Fibrosis leads to long-term (permanent) loss of your lung tissue's ability to carry oxygen. (ahealthyme.com)
  • Some forms of chILD are involved with immune responses and will require regular IVIG treatments to stop the progression of fibrosis in the lungs. (chop.edu)
  • The promoter variantcalledrs35705950is a common variantin theMUC5Bgene, with anallele frequency of 0.1 in the Finnish population.Overexpression ofMUC5Bin lungs influences the development of pulmonary fibrosis.The promoter variant rs35705950 inMUC5Bis the strongest known genetic risk factor for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). (eurekalert.org)
  • Besides involvement of skin, fibrosis also affects lung and heart. (clinicaltrials.gov)
  • The secondary objectives will be improvement in dyspnea, improvement in 6 min walk distance, change in DLCO, change in total lung capacity, change in the disability index of the Health Assessment Questionnaire (S HAQ), and change quality of life (SF-36), levels of NT pro-BNP and fibrosis markers. (clinicaltrials.gov)
  • Interstitial lung disease with pulmonary fibrosis. (sciencephoto.com)
  • Illustration based on a 3D computed tomography (CT) scan of the lungs of a patient with interstitial lung disease (ILD) that has developed into pulmonary fibrosis. (sciencephoto.com)
  • Most of these diseases later develop fibrosis (the formation of thickened scar tissue) in the lungs. (sciencephoto.com)
  • Diffuse interstitial lung diseases (DILD) are a group of chronic disorders showing varying degrees of active inflammation and established fibrosis mainly involving the interstitium of the lungs. (koreamed.org)
  • All new-onset interstitial pulmonary fibrosis cases in Connecticut will be enrolled in a population-based case-control study. (epa.gov)
  • Histopathology findings included subpleural and septal fibrosis, with areas of interspersed normal lung, diffuse interstitial fibrosis, histiocytes with foamy cytoplasm embedded in fibrosis, lymphoid aggregates, and focal type II alveolar cell hyperplasia. (mdpi.com)
  • Histopathology features of ILD in ECD can mimic interstitial fibrosis patterns observed in idiopathic ILD. (mdpi.com)
  • Commonly called pulmonary fibrosis, interstitial lung disease (ILD) accounts for more than 130 lung disorders - all of which are characterized by scarring of the lungs. (nyp.org)
  • Among the most common interstitial lung disorders are pulmonary fibrosis, hypersensitivity pneumonitis, sarcoidosis, and vascular granulomatosis. (nyp.org)
  • Interstitial lung diseases (ILD) are a heterogeneous group of diseases that produce inflammation and fibrosis of the parenchyma, affecting the alveolar, interstitial and vascular spaces. (appliedradiology.com)
  • Interstitial Lung Disease and Pulmonary Fibrosis are general terms used to describe inflammatory and fibrotic disorders of lung tissue (interstitium). (columbiasurgery.org)
  • There are over 100 known causes of interstitial lung disease and pulmonary fibrosis, which include familial and genetic disorders, inhaled substances, infections, medications, and connective tissue diseases. (columbiasurgery.org)
  • Idiopathic Pulmonary Fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation, accompanied by an uncontrolled healing response that causes progressive scarring or thickening (fibrosis) of tissues between the lung's alveoli, or air sacs. (columbiasurgery.org)
  • Furthermore, increased lung cancer risk is observed in people with asymptomatic pulmonary scarring ( 11 ) and with interstitial lung diseases, such as idiopathic pulmonary fibrosis ( 12-14 ). (aacrjournals.org)
  • Autoimmune diseases (in which the immune system attacks the body) such as lupus, rheumatoid arthritis , sarcoidosis , and scleroderma . (medlineplus.gov)
  • The book covers a wide array of disorders sarcoidosis, asbestosis, hypersensitivity pneumonitis, drug induced lung disease, connective tissue disease, and pulmonary vasculitis to name but a few. (ovid.com)
  • Unknown causes for some interstitial diseases, such as sarcoidosis - a condition in which tiny collections of inflammatory cells, or granulomas, grow in your lungs. (sutterhealth.org)
  • His clinical interests include sarcoidosis, pulmonary alveolar proteinosis, critical care and interstitial lung diseases. (clevelandclinic.org)
  • Rheumatoid arthritis, sarcoidosis and scleroderma are also disorders that can cause the disease. (hubpages.com)
  • Surgical lung biopsy: Surgery used in some cases to diagnose the type of lung disease. (massgeneral.org)
  • Diagnostic yield and postoperative mortality associated with surgical lung biopsy for evaluation of interstitial lung diseases: A systematic review and meta-analysis. (mayoclinic.org)
  • lung biopsy is often unnecessary. (aerzteblatt.de)
  • Surgical lung biopsy is seldom necessary. (aerzteblatt.de)
  • Here BAL can often replace lung biopsy. (nih.gov)
  • These tests can involve a biopsy of the lungs, where a tiny tissue sample is taken from the lungs to determine the condition of the lung. (mesotheliomasymptoms.com)
  • We might also recommend procedures such as bronchoscopy or surgical lung biopsy for a more accurate diagnosis. (sutterhealth.org)
  • In many cases, getting a lung biopsy (though bronchoscopy) can help nail down the problem and facilitate starting on the right course of treatment. (thebody.com)
  • [ 9 ] Patients with CVD who develop drug-induced ILD may also manifest a variety of histologic patterns in lung biopsy specimens. (medscape.com)
  • citation needed] A lung biopsy is required if the clinical history and imaging are not clearly suggestive of a specific diagnosis or malignancy cannot otherwise be ruled out. (wikipedia.org)
  • In cases where a lung biopsy is indicated, a trans-bronchial biopsy is usually unhelpful, and a surgical lung biopsy is often required. (wikipedia.org)
  • frequently then there is no need for a lung biopsy. (wikipedia.org)
  • We describe an extensive diagnostic process concluded by an open lung biopsy establishing a definitive diagnosis of this rare granulomatous lung disease. (scirp.org)
  • Lung biopsy , in which a sample of lung tissue is removed for testing, may be done, if necessary. (myositis.org)
  • All patients had biopsy-proven interstitial lung disease. (ebscohost.com)
  • Our program centers on safely taking a biopsy of the lung. (tuftsmedicalcenter.org)
  • Your surgeon will perform a minimally invasive thoracoscopy procedure known as Video Assisted Thoracic Surgery to take a biopsy of the diseased portion of your lung. (tuftsmedicalcenter.org)
  • Once the biopsy is complete and the lung tissue has been evaluated, we will send a report to your physician who will talk with you about treatment options. (tuftsmedicalcenter.org)
  • A lung needle biopsy is a method to remove a piece of lung tissue for examination. (limamemorial.org)
  • 4 Additional diagnostic workup can include bronchoalveolar lavage, transbronchial biopsy and surgical lung biopsy when indicated. (appliedradiology.com)
  • Lung inflammation due to breathing in a foreign substance such as certain types of dust, fungus, or mold ( hypersensitivity pneumonitis ). (medlineplus.gov)
  • Interstitial lung disease is the name given to a group of conditions that cause inflammation and scar tissue in the lungs, making it harder for them to work. (medicalnewstoday.com)
  • All of these involve scarring or inflammation of the interstitial lung tissue and affect the volume of oxygen that can reach the bloodstream via the respiratory system. (news-medical.net)
  • This is an X-ray to check the lungs for signs of inflammation or swelling. (massgeneral.org)
  • Interstitial lung disease is a condition that causes inflammation and thickening of the lungs. (massgeneral.org)
  • Interstitial lung disease is a term that encompasses several diseases, but the common thread between them is severe scarring in the lungs due to inflammation. (mesotheliomasymptoms.com)
  • This inflammation in the lungs can be caused by a number of environmental factors such as asbestos exposure, silica dust, cotton dust, coal dust, and hard metal dust. (mesotheliomasymptoms.com)
  • Cyclophosphamide is part of a class of drugs called immunosuppressants that suppress the immune response and reduces inflammation in the lungs. (ucsfhealth.org)
  • Injury or illness can cause inflammation in the lungs and airways. (denverhealth.org)
  • These diseases usually start with inflammation, which is reversible. (uhhospitals.org)
  • Interstitial lung disease (ILD) describes a large group of conditions that cause inflammation and scar tissue in the lungs. (aruplab.com)
  • Recent evidence suggests that use of biomarkers for lung injury and inflammation may be useful in the evaluation and management of ILD. (aruplab.com)
  • These agents in the environment trigger the host immune systems, causing inflammation, especially in a part of the lungs called the interstitium. (aruplab.com)
  • Interstitial lung disease is a condition that involves the inflammation of the lung tissue, interstitium. (hubpages.com)
  • In fact, I've read that enbrel (and perhaps some of the other biologics) may play a role in preventing the progression of ILD (perhaps by decreasing inflammation in and around the lungs? (healingwell.com)
  • Chest computerized tomography (CT) scan , especially a high-resolution CT (HRCT), is preferred as a way to detect interstitial lung disease, identify the severity of the disease, and distinguish between fibrotic disease and active inflammation in the lungs. (myositis.org)
  • Classic signs of ILD include ground glass opacities (a characteristic appearance that indicates inflammation in the air sacks), reduced lung volume, and bronchiectasis (enlargement of the airways). (myositis.org)
  • Immunosuppressive medications to treat both myositis and lung inflammation. (myositis.org)
  • Generally the inflammation spreads through out the lungs and is not confined to just one location. (targetwoman.com)
  • All the disorders grouped under ILD can cause inflammation and progressive scarring of the lung tissue. (targetwoman.com)
  • The common link between the many forms of the disease is that they all begin with an inflammation. (ahealthyme.com)
  • These diseases cause a thickening of the interstitium (the tissue that extends throughout the lungs) due to scarring, inflammation or fluid buildup. (chop.edu)
  • A course of prednisone for one week can reduce the oxidant burden and attendant inflammation and may be a strategy to prevent chronic TPE and interstitial lung disease. (hindawi.com)
  • This condition is a combination of interstitial lung disease associated with the pathologic lesion of respiratory bronchiolitis (inflammation of the bronchioles, the smallest air passages of the lungs). (advanceweb.com)
  • Interstitial lung disease, commonly known as ILD, is an umbrella term used to describe a group of rare conditions that all result in inflammation and scarring of the lung. (uhs.nhs.uk)
  • Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of dust, fungus, or molds. (limamemorial.org)
  • Inflammation and pulmonary diseases, including interstitial lung diseases, are associated with increased lung cancer risk. (aacrjournals.org)
  • More recently, studies have examined the role of inflammation in the etiology of lung cancer ( 4 ). (aacrjournals.org)
  • Both infectious and noninfectious lung diseases that cause extensive and prolonged pulmonary inflammation are associated with an increased risk of lung cancer. (aacrjournals.org)
  • SP-D is a component of pulmonary surfactant, plays a role in innate immunity, and modulates inflammation in the lung ( 16 ). (aacrjournals.org)
  • The lungs contain tiny air sacs (alveoli), which is where oxygen is absorbed. (medlineplus.gov)
  • In people with interstitial lung disease, this tissue becomes stiff or scarred, and the air sacs are not able to expand as much. (medlineplus.gov)
  • Many types of chILD affect the interstitium, a thin tissue between tiny air sacs and blood vessels in the lungs. (webmd.com)
  • The airways, air sacs, outer aspect of the lungs, and the blood vessels may be affected as well. (medicalnewstoday.com)
  • The interstitium supports the alveoli or tiny air sacs in the lungs. (medicalnewstoday.com)
  • Interstitial lung disease includes a group of diseases that have thickening of the supporting tissues between the air sacs of the lungs . (medicinenet.com)
  • Interstitial lung disease results from a variety of causes that lead to thickening of the supporting tissue around the air sacs rather than the air sacs themselves. (medicinenet.com)
  • ILD is actually a broad category of lung diseases that affect the tissue in the lungs around the air sacs and blood vessels. (caring.com)
  • In ILD, the walls of the air sacs in the lungs may become inflamed, and the tissue (interstitium) that lines and supports the sacs can become increasingly thickened and scarred. (ucsd.edu)
  • It affects the space around the small air sacs of the lung. (denverhealth.org)
  • Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of respiratory diseases affecting the interstitium (the tissue and space around the alveoli (air sacs)) of the lungs. (wikipedia.org)
  • Ordinarily, the body generates just the right amount of tissue to repair damage, but in interstitial lung disease, the repair process is disrupted, and the tissue around the air sacs (alveoli) becomes scarred and thickened. (wikipedia.org)
  • But in this condition, the repair is not fully attained and that the air sacs of the lungs are greatly affected resulting to scar tissue and thickening of the interstitial layer of the lungs. (hubpages.com)
  • The alveoli are the air sacs of the lungs. (wikipedia.org)
  • Interstitial lung disease is a group of diseases that affect the tissue and spaces (interstitial) around the air sacs (alveoli) in the lung. (myositis.org)
  • Interstitial lung disease or ILD refers to a wide group of lung diseases affecting the interstitium (tissue that surrounds and separates the tiny air sacs/alveoale of the lungs). (targetwoman.com)
  • In this disease the supportive tissues between the air sacs are inflamed rather than the air sacs themselves. (targetwoman.com)
  • It also destroys the lung tissue around the air sacs and the lung capillaries. (ahealthyme.com)
  • The air sacs, as well as the lung tissue around the air sacs and the lung capillaries, are destroyed when the scar tissue forms. (ahealthyme.com)
  • This thickening affects carbon dioxide and oxygen exchange between the alveoli (microscopic air sacs throughout the lungs) and the tissue surrounding them, which eventually affects a patient's ability to breathe and distribute enough oxygen to the blood. (chop.edu)
  • Interstitial lung disease describes a large group of disorders characterized by progressive scarring of the lung tissue between and supporting the air sacs. (omicsonline.org)
  • Symptoms of the other diseases such as arthritis or trouble swallowing (scleroderma), associated with ILD. (medlineplus.gov)
  • Signs and symptoms of chILD often depend on the type of disease and how severe it is. (webmd.com)
  • This thickening makes it difficult for the blood to absorb oxygen, which can lead to the symptoms of interstitial lung disease, such as breathlessness. (medicalnewstoday.com)
  • The most common symptoms of interstitial lung disease are a dry cough and shortness of breath . (medicinenet.com)
  • What are signs and symptoms of interstitial lung disease? (medicinenet.com)
  • Symptoms and signs of interstitial lung disease occur because the damage to the interstitium of the lung impairs breathing function. (medicinenet.com)
  • Interstitial lung disease that has been present for a long time may cause signs and symptoms related to lowering of the oxygen levels in the blood, such as clubbing of the fingertips and enlargement of the heart. (medicinenet.com)
  • The symptoms can also reflect the underlying disease process and assist in making a diagnosis. (medicinenet.com)
  • It is often difficult to make a diagnosis from symptoms alone, since so many lung diseases can present with shortness of breath and cough. (medicinenet.com)
  • Patients with interstitial lung disease-a group of disorders causing progressive scarring of lung tissue-are often prescribed various medications that specifically target their disease and others that treat their symptoms. (news-medical.net)
  • It can be hard to diagnose ILD because symptoms can be similar to other lung conditions. (massgeneral.org)
  • Learn the symptoms of interstitial lung disease. (massgeneral.org)
  • Improving the level of oxygen in the blood through the use of supplemental oxygen can help relieve strain on the heart and lungs and improve symptoms of shortness of breath and fatigue. (nationaljewish.org)
  • The most common symptoms of interstitial lung disease are shortness of breath, increased fatigue during exertion, coughing, and chest pains. (mesotheliomasymptoms.com)
  • The diagnosis of interstitial lung disease can often be difficult because the symptoms are very similar to other lung conditions and diseases. (mesotheliomasymptoms.com)
  • The treatment of interstitial lung disease is directed towards relieving symptoms and prevention of complications such as heart disease and high blood pressure. (mesotheliomasymptoms.com)
  • Pulmonary rehabilitation is a comprehensive program for lung disease patients whose symptoms are impacting their everyday activities. (ucsfhealth.org)
  • Damage to the lungs is permanent and cannot be reversed, but treatment will help to ease symptoms and improve quality of life. (denverhealth.org)
  • It is a type of interstitial lung disease, which is a group of 200 diseases with similar symptoms but different causes. (clevelandclinic.org)
  • The disease presents itself with the following symptoms: shortness of breath, nonproductive coughing, fatigue, and weight loss, which tend to develop slowly, over several months. (wikipedia.org)
  • The symptoms for this condition entirely depend on the extent of damage that the lungs have acquired. (hubpages.com)
  • Even though there are many diseases in the ILD category, a lot of them share certain signs and symptoms. (childrenshospital.org)
  • Interstitial lung disease can appear before muscle symptoms become apparent. (myositis.org)
  • Muscle and skin symptoms may be mild or even nonexistent, but interstitial lung disease may be severe. (myositis.org)
  • Patients with CTD who develop pulmonary symptoms should undergo testing to assess the severity of their disease (pulse oximetry, pulmonary function tests [PFTs]) as well as tests to determine the etiology. (oncologynurseadvisor.com)
  • Results of serial testing of gas transfer correlated with improvement of interstitial lung disease as characterized by resting Pa02, symptoms, and maximal duration of exercise. (ebscohost.com)
  • The symptoms and course of these diseases may vary from person to person. (ahealthyme.com)
  • What are the symptoms of interstitial lung diseases? (ahealthyme.com)
  • The symptoms of interstitial lung diseases may look like other lung conditions or health problems. (ahealthyme.com)
  • The following are the most common symptoms for interstitial lung diseases. (ahealthyme.com)
  • Treatment is aimed at preventing more lung scarring, managing symptoms, and helping you stay active and healthy. (ahealthyme.com)
  • In order to diagnose a form of interstitial lung disease, it is crucial to rule out all other possible causes of the contributing signs and symptoms. (chop.edu)
  • All treatment regimens will be focused on preventing disease progression and active illnesses, relieving symptoms, and maximizing growth and development. (chop.edu)
  • The primary signs and symptoms of interstitial lung disease include: Dry cough , Shortness of breath at rest or with exertion. (omicsonline.org)
  • Lung Diseases, Interstitial anonymous support group with information on diagnosis, treatment, symptoms, along with personal stories and experiences with Lung Diseases, Interstitial. (experienceproject.com)
  • Standard treatment for IPF is intended to improve symptoms and slow progression of the disease. (columbiasurgery.org)
  • There are many types of interstitial lung disease, all affecting the interstitium, which is the network of tissue running through both lungs. (medicalnewstoday.com)
  • The diagnosis of interstitial lung disease typically involves imaging tests, measurement of blood oxygen levels, and sometimes, biopsies or tissue sampling. (medicinenet.com)
  • Management of interstitial lung disease associated with connective tissue disease. (mayoclinic.org)
  • The term interstitial lung disease (ILD) is used for a category of diseases characterized by damage to the pulmonary interstitial tissue (sometimes involving alveolar epithelium and pulmonary blood and lymph vessels). (aerzteblatt.de)
  • Rheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. (nih.gov)
  • Most of those disorders cause progressive scarring of the lung tissue that eventually affects your ability to breathe and get enough oxygen into your blood stream, but beyond this the disorders vary greatly. (mcw.edu)
  • To confirm a diagnosis or determine the reason for scarring, a tissue sample may be removed from the lungs and closely examined. (denverhealth.org)
  • ILDs are a heterogeneous group of disorders, pathologically characterized by infiltration of the lung interstitium with cells, fluid, and/or connective tissue. (unboundmedicine.com)
  • Interstitial lung diseases are conditions that affect the lung tissue and make it harder for people to breathe. (sutterhealth.org)
  • They include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), dermatomyositis (DM)/polymyositis (PM), ankylosing spondylitis (AS), Sjögren syndrome (SS), and mixed connective-tissue disease (MCTD) . (medscape.com)
  • Approximately 15% of patients with an interstitial lung disease have an underlying connective-tissue disease. (medscape.com)
  • ILD may be the initial manifestation of a connective-tissue disease. (medscape.com)
  • [ 4 ] It has been suggested that some patients who have ILD but who do not meet clinical criteria for connective-tissue disorders may have a lung-predominant form of a connective-tissue disease. (medscape.com)
  • Because the prognosis, degree of reversibility, and optimal therapy differ for each disease presentation, a thorough knowledge of the pulmonary clinical picture of each connective-tissue disease is important. (medscape.com)
  • The pathogenesis of connective-tissue diseases is unknown. (medscape.com)
  • The probe is then cooled, allowing nearby lung tissue to freeze and attach itself. (uhhospitals.org)
  • But once the disease progresses to the development of scar tissue, it's nearly impossible to reverse. (uhhospitals.org)
  • In IPF, lung tissue becomes scarred. (clevelandclinic.org)
  • Typically, mild scarring of the lung tissue occurs first, but over months to years, the normal lung tissue is replaced by more heavily scarred lung tissue, which makes it difficult to breathe and deliver needed oxygen to the body. (clevelandclinic.org)
  • The scarring replaces normal lung tissue, damaging how the lungs work and making it harder to get needed oxygen. (uvahealth.com)
  • This is a surrounding tissue of the lungs that separates the alveola. (hubpages.com)
  • The scarring of the lung tissue makes this condition progressive. (hubpages.com)
  • If it progresses, the lung tissue thickens and becomes stiff. (ahealthyme.com)
  • Bronchoscopy helps to evaluate and diagnose lung problems, check blockages, take out samples of tissue or fluid, and help remove a foreign body. (ahealthyme.com)
  • This test removes a small piece of tissue from the lung so it can be checked under a microscope. (ahealthyme.com)
  • Removing a small piece of tissue from the lung so it can be examined under a microscope. (ahealthyme.com)
  • Investigators from Italy gathered and summarized the available related literature in order to organize the available data and recent advances about therapeutic strategies for ILD in the context of other connective tissue diseases (CTDs). (ajmc.com)
  • idiopathic and DILD with known-cause, such as connective tissue diseases associated with DILD. (koreamed.org)
  • Reata has already pushed the drug, bardoxolone methyl, into phase 3 in patients with connective tissue disease associated pulmonary hypertension. (fiercebiotech.com)
  • Irving, Texas-based Reata has already pushed the drug, bardoxolone methyl, into phase 3 in patients with connective tissue disease associated pulmonary hypertension (CTD-PAH) on the back of midphase evidence of its effect on six-minute walk distances. (fiercebiotech.com)
  • Scleroderma is a disease that involves the buildup of scar-like tissue in the skin and elsewhere in the body. (limamemorial.org)
  • A case of mixed connective tissue disorder with interstitial lung disease: case report. (thefreelibrary.com)
  • Mixed connective tissue disorder is a disease characterized by elevated titres of specific antinuclear antibody against U1 ribonucleoprotein (Anti-U1 RNP). (thefreelibrary.com)
  • Mixed connective tissue disease is relatively rare and the vast majority of people with the disease (80 percent) are women. (thefreelibrary.com)
  • The diagnosis of interstitial lung disease has become significantly more accurate as a result of thoracoscopy, a minimal access procedure that uses small incisions and video-endoscopic instruments to view the chest . (columbiasurgery.org)
  • Breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. (medlineplus.gov)
  • Some types of interstitial lung disease have no known cause. (medlineplus.gov)
  • Recent research focused on the pathogenesis of various types of interstitial lung disorders. (nih.gov)
  • Not all types of interstitial lung disease that occur in adults occur also in children, and vice versa. (wikipedia.org)
  • Some forms of interstitial lung disease lead to irreversible scarring and respiratory failure. (medicinenet.com)
  • Inhalation of tobacco smoke is a risk factor for various diseases of the lungs and respiratory tract. (aerzteblatt.de)
  • Because these problems are vague and tend to develop gradually - often long after you have irreversible lung damage - you may attribute them to aging, to being overweight or out of shape, or to the residual effects of respiratory infection. (mcw.edu)
  • Our rehabilitation team includes pulmonologists, respiratory therapists, exercise physiologists, dietitians, specially trained nurses and other experts to help improve your lung function. (uhhospitals.org)
  • Everyone, even those with no sx, should have a comprehensive physical including a pulmonary physical--especially with the high incidence of respiratory disease in this country. (healingwell.com)
  • American Review of Respiratory Disease, 139(1), 233-241. (scirp.org)
  • Respiratory synctytial virus (RSV) is a common virus that can be especially damaging to the lungs of patients with interstitial and diffuse lung disease. (chop.edu)
  • It is differentiated from Respiratory Bronchiolitis-associated Lung Disease (RB-ILD) by the fact that DIP affects the lung in a uniform diffuse pattern and is not focused in the bronchioles. (advanceweb.com)
  • Over long periods of time, the disease can cause respiratory and heart failure. (columbiasurgery.org)
  • According to the American Thoracic Society , there are more than 200 different lung disorders that affect the interstitium. (medicalnewstoday.com)
  • A lung infection occurring within the interstitium. (medicalnewstoday.com)
  • Disease of the interstitium is recognized on imaging studies as a thick lace (sponge), sometimes symmetric, and in other types, scattered and irregular. (medicinenet.com)
  • In the lungs, these disorders affect the interstitium, which is the space around the alveoli. (wikipedia.org)
  • Some types of ILD, like rheumatoid arthritis, happen when your immune system overreacts to your own body and damages your lungs. (uvahealth.com)
  • Interstitial lung disease can also be associated with rheumatological diseases such as rheumatoid arthritis or scleroderma, as well as other less common conditions. (uhs.nhs.uk)
  • Rheumatoid arthritis (RA) is a long-term disease. (limamemorial.org)
  • Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become inflamed and then damaged. (medlineplus.gov)
  • Disorders that cause problems with surfactant -- a fluid in the lungs that helps your child breathe -- can be passed on through genes. (webmd.com)
  • This group includes opportunistic infection, disorders related to therapeutic intervention, lung and bone marrow transplant-associated lung diseases, and diffuse alveolar damage of unknown cause. (webmd.com)
  • Interstitial lung disease (ILD) is a broad group of lung diseases comprising of more than a hundred distinct disorders. (news-medical.net)
  • Doctors normally begin by taking a comprehensive medical history, focusing especially on occupational exposure to lung-damaging toxins, on medications and on the presence of health problems commonly associated with lung disorders. (mcw.edu)
  • All ILD disorders affect this particular area of the lung. (denverhealth.org)
  • 40. Interstitial Lung disease in Childhood Rheumatic Disorders. (routledge.com)
  • 42. Lymphoproliferative Disorders of the Lung. (routledge.com)
  • Collagen-vascular diseases (CVDs) are a heterogeneous group of autoimmune disorders characterized by the presence of autoantibodies. (medscape.com)
  • Since ILD is not a single disease but a group of more than 200 different pulmonary disorders, it can be confusing to understand exactly what you are dealing with, how a diagnosis is made and who needs to be involved. (clevelandclinic.org)
  • Smoking-associated interstitial lung disease manifests as several heterogeneous disorders involving the airways, pleura, and lung parenchyma with various radiological patterns. (unboundmedicine.com)
  • Childhood interstitial lung disease, sometimes abbreviated as ChILD, is a family of rare chronic and complex disorders that affect the lungs of children. (wikipedia.org)
  • The interstitial lung diseases (ILDs) are a group of diffuse parenchymal lung disorders that are classified according to their specific clinical, radiological, and histopathological features. (oncologynurseadvisor.com)
  • Many CTDs can also be associated with disorders of the pleura, airways, and pulmonary vasculature as well, but this section will discuss parenchymal lung disease or ILD. (oncologynurseadvisor.com)
  • Interstitial lung disease is caused by extrinsic or environmental exposures, intrinsic or systemic diseases, genetic disorders, or a combination of the above. (brighamandwomens.org)
  • Interstitial lung disease is the name for a group of more than 200 ongoing (chronic) lung disorders. (ahealthyme.com)
  • This code should continue to be assigned if the NSIP is due to some other underlying cause, such as collagen vascular disease, hypersensitivity pneumonitis, infection, or drug-induced pneumonitis. (advanceweb.com)
  • In Pulmonary Arterial Hypertension and Interstitial Lung Disease: A Clinical Guide, renowned experts provide a state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. (springer.com)
  • Smoking-related interstitial lung diseases (SR-ILDs) are a heterogeneous group of diseases with major clinical significance. (aerzteblatt.de)
  • The cause of most interstitial lung diseases (ILDs) is still unknown. (clinicaltrials.gov)
  • Protocol title: 'Registration of clinical data and DNA of patients with Interstitial Lung Disease (ILD)' Rationale: The etiopathogenesis of most Interstitial Lung Diseases (ILDs) is still unknown. (clinicaltrials.gov)
  • NUH is host to the regional centre for interstitial lung disease (ILD) and the national lymphangioleiomyomatosis (LAM) centre, providing care for patients with ILDs from across the East Midlands and nationally for patients with LAM. (nuh.nhs.uk)
  • This course provides an overview of the field of Interstitial Lung Diseases (ILDs). (ersnet.org)
  • Optimal care for interstitial lung diseases (ILDs) depends heavily on a team of specialists whose complementary skills provide each patient with a full range of options. (upmc.com)
  • Patients will receive information regarding the latest medical treatment and ongoing clinical research trials, as well as discussion of lung transplantation. (ohsu.edu)
  • Researchers have identified that dysfunction of a specific immune cell, called B cells, underlies lung disease that affects patients with the rare immunological disorder known as common variable immunodeficiency. (news-medical.net)
  • Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line) trial showed improved intracranial progression-free survival (PFS) and intracranial objective response rate (ORR) with ALUNBRIG (brigatinib) compared to crizotinib among anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) patients. (news-medical.net)
  • Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved VIZIMPRO [vih-ZIM-pro] (dacomitinib), a kinase inhibitor for the first-line treatment of patients with metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test. (news-medical.net)
  • As one of the largest interstitial lung disease referral centers in the United States, we have access to patients, biological samples and animal models that can help solve the mysteries of these complex diseases and improve care for patients who suffer from them. (nationaljewish.org)
  • Long-term results and predictors of survival after surgical resection of patients with lung cancer and interstitial lung diseases. (mayoclinic.org)
  • We know that a significant number of patients with metastatic breast carcinoma who have been heavily pretreated with multiple different chemotherapy regimens and still experience disease progression have a response to treatment with this antibody-drug conjugate with extended progression-free survival time," Dr. Powell told Reuters Health. (medscape.com)
  • And amongst the risks is that of interstitial lung disease, which was identified early on as a potentially clinically significant risk for patients treated with this compound," he added. (medscape.com)
  • Bronchoalveolar lavage (BAL) has become a standard diagnostic procedure for the majority of patients with interstitial disease. (nih.gov)
  • Anti-inflammatory medications are commonly prescribed to patients with interstitial lung disease as well. (mesotheliomasymptoms.com)
  • A Yugoslavian study of six non-smoking asbestos exposure patients showed that interstitial lung disease could be detected early through tests of the flow rate of air through bronchioles and high resolution CT scans. (mesotheliomasymptoms.com)
  • Another important objective of the ILD Center is the early identification of patients for lung transplantation which is also offered at our institution. (mcw.edu)
  • Researchers from the University of Pennsylvania developed a texture-based image classification model for high-resolution CT that substantially outperformed expert radiologist classifications of UIP versus non-UIP in predicting survival in a study involving 40 interstitial lung disease patients. (auntminnie.com)
  • In a retrospective study, the researchers collected 40 patients with interstitial lung disease, including 20 with a UIP pattern and 20 with a non-UIP pattern on CT. (auntminnie.com)
  • The patients were followed up for seven years, and outcomes included time to death or time to lung transplantation. (auntminnie.com)
  • In future directions, the researchers plan to validate their texture-based quantitative CT predictive models on a much larger cohort of over 500 interstitial lung disease patients, Barbosa said. (auntminnie.com)
  • ILD can be a difficult disease to treat, sometimes progressing slowly, and in other patients, very quickly. (ucsd.edu)
  • The UCSF Interstitial Lung Disease (ILD) Program is dedicated to improving the lives of patients with interstitial lung disease, or ILD. (ucsfhealth.org)
  • Patients living with interstitial lung disease (ILD) will find numerous resources listed here, offering information and support. (ucsfhealth.org)
  • In patients with HRCT extent of 10-30% (termed indeterminate disease), an FVC threshold of 70% was an adequate prognostic substitute. (nih.gov)
  • Diuretics - Diuretics, or water pills, help prevent swelling and are sometimes useful in improving heart and lung function in PH patients. (ucsfhealth.org)
  • At our multidisciplinary conference attended by pulmonologists, radiologists and rheumatologists, we discuss each and every one of our interstitial lung disease patients. (sutterhealth.org)
  • The lungs are involved in more than 50% of patients with systemic sclerosis. (medscape.com)
  • This support group helps patients and their families better understand lung conditions, learn additional coping techniques and receive emotional support. (uhhospitals.org)
  • In some patients, the disease is genetic (you inherited the disease from your parents). (clevelandclinic.org)
  • A proper and detailed history looking for the occupational exposures, and for signs of conditions listed above is the first and probably the most important part of the workup in patients with interstitial lung disease. (wikipedia.org)
  • citation needed] Chest radiography is usually the first test to detect interstitial lung diseases, but the chest radiograph can be normal in up to 10% of patients, especially early on the disease process. (wikipedia.org)
  • Both SP-D and KL-6 biomarkers may be helpful in monitoring patients with an established diagnosis of ILD because both markers increase with disease exacerbation and decrease with treatment and disease improvement. (aruplab.com)
  • This case underlines the importance of a thorough diagnostic work up and the pathogenic potential of foreign material reaching the lung via blood circulation in amongst the differential diagnoses of interstitial lung diseases, especially occurring in this group of patients. (scirp.org)
  • The center conducts both laboratory and patient-oriented research, and is involved in most major clinical trials for patients with interstitial lung disease. (uclahealth.org)
  • Patients who wish to learn more about these research opportunities are encouraged to speak with their doctors in the UCLA Interstitial Lung Disease Center. (uclahealth.org)
  • Researchers estimate that 30-40% of myositis patients have some form of lung disease. (myositis.org)
  • Of those patients who have interstitial lung disease, about 75% have anti-Jo-1 antibodies. (myositis.org)
  • Of those who have interstitial lung disease, the disease seems to be worse in African American patients versus Caucasian patients. (myositis.org)
  • Autoantibody blood tests can not only confirm a diagnosis of myositis, but the presence of an antisynthetase antibody can identify patients who are at risk for developing interstitial lung disease. (myositis.org)
  • Physicians and surgeons in the Interstitial Lung Disease Clinic at the Brigham and Women's Hospital (BWH) Lung Center provide comprehensive, specialized care for patients with ILD. (brighamandwomens.org)
  • Patients benefit from the full range of services and expertise offered at BWH and through the ILD Clinic at Lung Center . (brighamandwomens.org)
  • Six patients with interstitial lung disease were tested in a serial fashion to determine response to medications. (ebscohost.com)
  • The value of serial testing of patients with interstitial lung disease is discussed. (ebscohost.com)
  • The article describes the clinical cases of three patients, diagnosed with stage IV non-small cell lung cancer, who developed interstitial lung disease (ILD) while under gefitinib treatment regimen. (ebscohost.com)
  • The article describes the clinical cases of seven patients who developed interstitial lung disease (ILD) after receiving everolimus for metastatic renal cell carcinoma. (ebscohost.com)
  • The article discusses the retrospective study which shows the number of patients who developed interstitial lung disease after receiving everolimus, sunitinib or temsirolimus treatment for metastatic renal cell carcinoma. (ebscohost.com)
  • Our Young Lungs Program brings national experts together with parents of patients and other key stakeholders around the country to raise awareness and increase support for children with chILD and other rare lung diseases. (lungfoundation.com.au)
  • Encourage your patients to sign up up to our LungNet email newsletter for the latest information on support services, resources and events that will help them live well with their lung condition. (lungfoundation.com.au)
  • This is a phase 2, open label, single center randomized clinical trial to determine the tolerability and safety of pirfenidone in patients with BOS associated with lung GVHD after hematopo. (bioportfolio.com)
  • For patients with low or no disease progression, the current treatment includes routine follow-up. (ajmc.com)
  • Radiologic features of low fibrotic scores at high-resolution CT and early enhancement patterns at dynamic enhancement of MRI can be useful prognostic determinants for the prediction of disease improvement in patients with fibrotic IIPs. (koreamed.org)
  • Reata Pharmaceuticals has linked its Nrf2 transcription factor activator to improved six-minute walk test results in patients with interstitial lung disease (ILD). (fiercebiotech.com)
  • To the editor: Dr. Durant and his associates in the Southeastern Cancer Study Group (SECSG) reported in the February 1979 issue (1) 10 patients who developed an interstitial pulmonary disease while undergoing multiple-agent antineoplastic regimens that included bischlorethylnitrosourea (BCNU). (annals.org)
  • While poor sleep quality is common in patients with interstitial lung disease (ILD), it is unclear which factors other than sleep disordered breathing may contribute to poor sleep quality for these patients. (ajmc.com)
  • Cho J-G, Teoh A, Roberts M, Wheatley J. The prevalence of poor sleep quality and its associated factors in patients with interstitial lung disease: a cross-sectional analysis. (ajmc.com)
  • Experts in the Division of Pulmonary and Critical Care Medicine at Mayo Clinic provide comprehensive consultative, diagnostic and therapeutic services for patients with illnesses that affect the lungs and breathing. (mayo.edu)
  • Walker and colleagues recently reported a series of patients with interstitial pneumonitis following use of statin cholesterol-lowering drugs. (mja.com.au)
  • In a study by Gunnarasson et al of 126 patients with MCTD, 52% of them had HRCT features consistent with interstitial lung disease. (thefreelibrary.com)
  • Circulating levels of surfactant protein-D (SP-D) and Krebs von Lungren-6 (KL-6) are elevated in interstitial lung disease patients and may be useful markers of processes contributing to lung cancer. (aacrjournals.org)
  • SP-D levels are also elevated in patients with chronic obstructive pulmonary disease (COPD), particularly during COPD exacerbations ( 17, 18 ). (aacrjournals.org)
  • Refer to local trust policies if available or see the British Thoracic Society's guidance on venous thromboembolic disease in patients with COVID-19 . (nice.org.uk)
  • The U.S. Food and Drug Administration today approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. (news-medical.net)
  • University of Tsukuba-led team reveals the association between a gene variant and a lung disease in the form of systemic vasculitis particularly prevalent in the Japanese, potentially providing a target for future therapies. (news-medical.net)
  • Interstitial lung disease in systemic sclerosis: a simple staging system. (nih.gov)
  • In interstitial lung disease complicating systemic sclerosis (SSc-ILD), the optimal prognostic use of baseline pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) is uncertain. (nih.gov)
  • Autoantibodies to MDA5 and PM-Scl (an antibody prevalent in polymyositis/systemic scleroderma overlap) are also associated with interstitial lung disease. (myositis.org)
  • Look for extrapulmonary evidence of a systemic disease including joint deformities, skin tightness, telangiectasia, petechial hemorrhages, rash and mechanical hands signs of CTD. (oncologynurseadvisor.com)
  • Systemic sclerosis (SSc, scleroderma) is a multisystem autoimmune rheumatic disease that causes in﫿ammation, vascular damage and 﫿brosis. (clinicaltrials.gov)
  • The effects of some drugs on the lungs are similar to those of systemic lupus erythematosus (lupus). (merckmanuals.com)
  • Second, if the prognosis is poor the indications for lung transplantation should be determined early. (aerzteblatt.de)
  • The Interstitial Lung Disease Program at Inova Fairfax Medical Campus provides comprehensive care for the entire spectrum of interstitial lung diseases, from mild to advanced-stage diseases requiring lung transplantation - all in a single center. (inova.org)
  • That's when the specialists at University Hospitals can help you explore lung transplantation options. (uhhospitals.org)
  • 1998) Recurrence of intravenous talc granulomatosis following single lung transplantation. (scirp.org)
  • In the final article, lung transplantation is discussed. (elsevier.com)
  • Your care plan may include a variety of medications, oxygen therapy, pulmonary rehabilitation and, when indicated, lung transplantation. (brighamandwomens.org)
  • Transplantation is considered an option when life expectancy from end-stage lung disease is limited and there are no other available medical or surgical therapies available. (chop.edu)
  • Lung transplantation has been successful as a treatment of last resort. (columbiasurgery.org)
  • Interstitial lung disease can be acute (coming on suddenly) or chronic (occurring over time). (medicinenet.com)
  • Besides chronic obstructive pulmonary disease, pulmonary emphysema, and lung cancer, this group of diseases includes smoking-related interstitial lung disease (SR-ILD). (aerzteblatt.de)
  • Pulmonary rehabilitation (PR) is an excellent therapeutic option in another chronic lung diseases such as chronic obstructive pulmonary disease (COPD). (clinicaltrials.gov)
  • Drug-induced interstitial lung disease (DI-ILD), defined as an interstitial abnormality secondary to administration of a drug, can be acute or chronic. (appliedradiology.com)
  • Pulmonary tuberculosis, Chlamydia pneumoniae infection, chronic bronchitis, and emphysema have each been associated with increased lung cancer risk ( 5-10 ). (aacrjournals.org)
  • National Jewish Health has a tremendous clinical research program whose investigators seek to systematically advance understanding of interstitial lung disease (ILD), including its epidemiology, natural history, and prognosis. (nationaljewish.org)
  • Approach to the adult with interstitial lung disease: Clinical evaluation. (mayoclinic.org)
  • Apart from clinical examination and determination of lung function, the most important instrument in the diagnosis of ILD is high-resolution computer tomography. (aerzteblatt.de)
  • If a BAL finding is compatible with the suspected diagnosis in the context of an appropriate disease history and clinical and radiologic findings, this can then be sufficient for disease confirmation. (nih.gov)
  • The clinical value of BAL to assess the activity of disease processes and to provide prognostic information is still under debate. (nih.gov)
  • These models, by capturing latent quantitative CT-derived lung parenchymal texture features not explicitly accounted for in clinical diagnostic labels such as UIP versus non-UIP, may provide more accurate prognostication, ultimately contributing to more effective patient management and possibly improving long-term outcomes," said presenter Dr. Eduardo Mortani Barbosa Jr. (auntminnie.com)
  • His clinical interests include critical care, interstitial lung disease and general pulmonary medicine. (clevelandclinic.org)
  • Radiologic appearance alone however is not adequate and should be interpreted in the clinical context, keeping in mind the temporal profile of the disease process. (wikipedia.org)
  • The clinical history, radiologic, and pathologic findings are important to distinguish these more uncommon diseases. (unboundmedicine.com)
  • Consensus between the clinical, radiographic, and pathologic findings is important in identifying and differentiating between the various entities to properly diagnose smoking-related interstitial lung diseases discussed in this review. (unboundmedicine.com)
  • An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung diseas. (wikipedia.org)
  • The article describes the clinical cases of 12 men and eight women, aged 55 to 84 years with advanced non-small cell lung cancer, who developed interstitial lung disease after receiving erlotinib or gefitinib. (ebscohost.com)
  • The SIOLD project aims at promoting clinical, genetic and epidemiologic research on interstitial lung diseases and rare lung diseases. (chuv.ch)
  • Interstitial lung disease requires a multidisciplinary clinical approach, though little is known about effective therapeutic treatments. (ajmc.com)
  • Interstitial lung disease (ILD) should be treated with a multidisciplinary clinical and therapeutic approach but treatment with conventional drugs may be based on studies with insufficient research, according to a literature review. (ajmc.com)
  • Increased telomere attrition and decay are thought to play a causative role in the clinical and pathological manifestations of the disease. (hindawi.com)
  • This course will place into clinical context a variety of histopathologic features one might see in lung biopsies of ILD. (uscap.org)
  • Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff. (patientsville.com)
  • Most of the interstitial lung diseases are diagnosed as pneumoconiosis (drug-induced disease) or hypersensitivity pneumonitis. (targetwoman.com)
  • Although advances in understanding in pathophysiology and use of immunosuppressive therapy has brought significant improvement in outcome of other autoimmune diseases, scleroderma still remains as a disease with high mortality and 10 yr survival rate has improved only from 54% to 66% during last 25 years1. (clinicaltrials.gov)
  • During the course of his disease, he additionally developed scleroderma. (rug.nl)
  • Bronchoalveolar lavage, performed because of increase of interstitial markings in the presence of enlarged hilar nodes, showed an increased percentage of granulocytes and a low CD4 to CDS ratio of lymphocytes, suggesting a change to scleroderma lung disease. (rug.nl)
  • These etiologic agents are phagocytosed by alveolar macrophages or bronchial epithelial cells and release chemotactic factors that recruit inflammatory cells to the lung. (hindawi.com)
  • The technique of bronchoalveolar lavage in humans has recovered alveolar macrophages (AMs) in dust diseases and eosinophils in TPE that release increased amounts of oxidants in vitro. (hindawi.com)
  • Oxidants in the lung can be from endogenous sources since air pollutants activate neutrophils, alveolar macrophages, eosinophils, and epithelial cells. (hindawi.com)
  • SP-D and KL-6 are both produced by pulmonary alveolar type II cells, which proliferate during lung injury ( 20 ). (aacrjournals.org)
  • The Massachusetts General Hospital Interstitial Lung Disease Program multidisciplinary team includes lung specialists, chest radiologists, pulmonary pathologists, thoracic surgeons and research scientists. (massgeneral.org)
  • The chest x-rays are used to test for and rule out conditions like a collapsed lung and emphysema. (mesotheliomasymptoms.com)
  • Meticulous attention to imaging technique and specialized knowledge are required to properly perform and interpret chest imaging studies obtained for the evaluation of childhood interstitial lung disease (chILD). (nih.gov)
  • She has had chest/lung pains for the past 3 months now. (thebody.com)
  • We also perform an occupational history and use high-resolution chest computed tomography (CT) scans, lung function tests and walking evaluations. (uhhospitals.org)
  • Less commonly but on occasion, your doctor may do repeat imaging such as a chest x-ray or CT scan to see if your disease is worsening. (clevelandclinic.org)
  • Chest x-ray is the first step that can indicate abnormalities as well as how the disease is progressing. (myositis.org)
  • While interstitial lung disease is by far the most common lung-related complication of myositis, other factors may also involve the chest and lungs that might make it difficult to breathe. (myositis.org)
  • Chest radiograph and PFTs with lung volumes and carbon monoxide diffusing capacity (DLCO) measurement should also be obtained. (oncologynurseadvisor.com)
  • She had developed a fever 1 week before admission, and a chest radiograph revealed patchy airspace infiltrates in both lungs (fig. 1a). (redgage.com)
  • She had no past history of pulmonary disease and her chest radiograph the previous month was normal. (redgage.com)
  • If you need help for a lung or chest issue, we're here for you. (columbiasurgery.org)
  • We conducted a nested case-control study, including 532 lung cancer cases, 582 matched controls, and 150 additional controls with chest X-ray (CXR) evidence of pulmonary scarring, in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. (aacrjournals.org)
  • It is also known as diffuse parenchymal lung disease (DPLD). (targetwoman.com)
  • It may involve medicines, oxygen therapy, or a lung transplant in severe cases. (medlineplus.gov)
  • Some people with advanced ILD may need a lung transplant. (medlineplus.gov)
  • A lung transplant or bone marrow transplant may be to blame for certain cases of chILD. (webmd.com)
  • Lung Transplant: Is it right for you? (nationaljewish.org)
  • In severe cases where the lungs are extremely damaged, a lung transplant might be recommended. (mesotheliomasymptoms.com)
  • In certain cases, a lung transplant may be appropriate. (ucsd.edu)
  • In severe ChILD cases, a lung transplant may prove effective. (wikipedia.org)
  • If other therapies do not improve ILD, your physician may recommend referral and evaluation by a lung transplant program. (brighamandwomens.org)
  • Learn more about BWH's Division of Thoracic Surgery and Lung Transplant Program . (brighamandwomens.org)
  • There was poor data regarding survival after a lung transplant, and what exists was contradictory, the study authors found. (ajmc.com)
  • A Story of Life","https://brightcove.hs.llnwd.net/e1/uds/pd/4365621440001/4365621440001_5256995447001_5256973786001.mp4?pubId=4365621440001&videoId=5256973786001","Lung donation and transplant offers new life. (upmc.com)
  • Lung donation and transplant offers new life. (upmc.com)
  • Some people with ILD develop heart failure and high blood pressure in the blood vessels of their lungs. (medlineplus.gov)
  • Shortness of breath affects the breathing passages and the lungs, the heart, or blood vessels. (medicinenet.com)
  • It can be caused by a thickening of the pulmonary artery walls, heart failure , lung disease (such as interstitial lung disease ), and clots within the lungs' blood vessels. (ucsfhealth.org)
  • This is a special type of CT scan used to study the blood vessels in your lungs. (ucsfhealth.org)
  • 1 ILD can affect other parts of the lungs too, such as the airways, lung lining, and blood vessels. (aruplab.com)
  • This new edition also features an examination of future potential therapies for interstitial lung disease. (ovid.com)
  • PH-specific therapies are designed to reduce the blood pressure within the lungs. (ucsfhealth.org)
  • Identifying the source helps UH's pulmonary specialists determine the best course of interstitial lung disease treatment, including innovative therapies. (uhhospitals.org)
  • From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. (merckmanuals.com)
  • And we know that that benefit is accompanied by a risk, such as is the case for all treatments and for all diseases, especially in oncological drugs. (medscape.com)
  • Medical treatments such as medications can damage the lungs. (hubpages.com)
  • Radiation and chemotherapy - those who undergo these treatments may develop interstitial lung disease. (hubpages.com)
  • Some are caused by another disease, and some are even caused by treatments for other medical problems. (childrenshospital.org)
  • Pirfenidone slows the progression of disease for some people with IPF. (nationaljewish.org)
  • However, the progression of diseases and the other parts of the lungs that may be affected are unique to each disorder. (denverhealth.org)
  • The goal of treatment is to slow progression of the disease. (denverhealth.org)
  • The goals of therapy are to preserve current lung function and slow disease progression. (clevelandclinic.org)
  • Frequent pulmonary function tests (PFTs) to monitor disease progression or progress. (myositis.org)
  • High resolution CT (HRCT) scans may be done to monitor disease progression or progress. (myositis.org)
  • Breathlessness worsens with the progression of the disease. (targetwoman.com)
  • Interstitial lung disease in lung cancer: separating disease progression from treatment effects. (ebscohost.com)
  • The lung scarring that occurs in interstitial lung disease is often irreversible, and treatment will not always be effective in stopping the ultimate progression of the disease. (omicsonline.org)
  • This scarring can cause the lung to become stiff and cause shortness of breath and interfere with lung function. (ucsd.edu)
  • The common signs of interstitial lung disease are shortness of breath and dry cough. (hubpages.com)
  • The dry cough and shortness of breath caused by interstitial lung disease can be anxiety-provoking and irritating. (tuftsmedicalcenter.org)
  • ILD results in loss of lung volume, impairing gaseous exchange and causing shortness of breath. (sciencephoto.com)
  • Shortness of breath is a main symptom of interstitial lung disease. (limamemorial.org)
  • Childhood interstitial lung disease , known as "chILD," is a group of rare lung conditions that affect babies, kids, and teens . (webmd.com)
  • Childhood interstitial lung disease is a serious condition, with high morbidity and mortality. (wikipedia.org)
  • American Thoracic Society Committee on Childhood Interstitial Lung Disease (chILD) the chILD Research Network (2013). (wikipedia.org)
  • This is referred to as Interstitial Pneumonitis with Autoimmune Features (IPAF) or lung-dominant CTD. (oncologynurseadvisor.com)
  • Several forms of interstitial lung disease are unique to children, and some forms of interstitial lung disease encountered in adults rarely, if ever, occur in children. (nih.gov)
  • Some cases of interstitial lung disease do not have an identifiable cause and are referred to as idiopathic. (medicinenet.com)
  • Although most cases of interstitial lung disease develop gradually, a few come on suddenly. (mcw.edu)
  • Doctors can pinpoint why some cases of interstitial lung disease occur, but many have no known cause. (mcw.edu)
  • NEW YORK (Reuters Health) - New data confirm a risk for interstitial lung disease (ILD) in women with HER2-positive metastatic breast cancer receiving the antibody-drug conjugate trastuzumab deruxtecan (T-DXd) but show that most cases are mild and occur early. (medscape.com)
  • Who are at risk for Interstitial lung disease? (targetwoman.com)
  • They may all look the same on a computed tomography (CT) scan, but it's important to identify the source of the interstitial lung disease. (uhhospitals.org)
  • Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease of unknown aetiology. (ebscohost.com)
  • Limited information is available regarding interstitial lung disease (ILD) in Erdheim-Chester disease (ECD), a rare multisystemic non-Langerhans cell histiocytosis. (mdpi.com)
  • The prognosis of interstitial lung disease depends on the precise cause. (medicinenet.com)
  • There is a more favorable prognosis, but lung function tests typically show similar but milder physiological abnormalities than those found in IPF. (advanceweb.com)
  • Interstitial lung disease affects bronchioles, which are the small airways in the lungs. (mesotheliomasymptoms.com)
  • P268 Is bronchiectasis severity influenced by aetiology or co-morbid airways disease? (bmj.com)
  • The term ILD is used to distinguish these diseases from obstructive airways diseases. (wikipedia.org)
  • Cigarette smoking is associated with a variety of pathologic conditions that affect the airways and lungs. (unboundmedicine.com)
  • Disease-related changes can cause the large airways in the lungs to slowly narrow. (ahealthyme.com)
  • This is direct exam of the main airways of the lungs (bronchi) using a flexible tube called a bronchoscope. (ahealthyme.com)
  • Bronchoscopy is a test to view the airways and diagnose lung disease. (limamemorial.org)
  • 31. Drug-Induced Interstitial Pneumonitis in Children. (routledge.com)
  • As they noted, this agent has already been implicated as a cause of drug-induced pulmonary disease (1-5). (annals.org)
  • As the disease worsens and the alveoli become thicker, they also begin to lose their elasticity. (mesotheliomasymptoms.com)
  • DIP is another disease process that involves an accumulation of macrophages, in this case in the alveoli. (advanceweb.com)
  • This course is targeted toward practicing surgical pathologists (including trainees) who routinely encounter lung biopsies for suspected interstitial lung disease (ILD). (uscap.org)
  • This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. (nih.gov)
  • Once lung damage occurs, it is generally irreversible. (aruplab.com)
  • As the lung tissues are scarred, irreversible effects are to be expected. (hubpages.com)
  • Lung scarring is generally irreversible. (targetwoman.com)
  • The diagnosis of this lung disease requires tests such as x-rays, CT scans, and pulmonary function tests. (mesotheliomasymptoms.com)
  • Pulmonary function tests are a group of tests that measure breathing and how well the lungs are functioning. (limamemorial.org)
  • Your lung specialist may then schedule additional meetings and/or testing to diagnose your specific disorder and formulate a treatment plan. (massgeneral.org)
  • How do doctors test for and diagnose interstitial lung disease (ILD)? (massgeneral.org)
  • But although a medical history and physical exam can be useful in ruling out certain conditions, they can't accurately diagnose interstitial lung disease. (mcw.edu)
  • Fibrosing interstitial lung diseases require considerable expertise to diagnose and manage, and confident diagnosis may be elusive even when expert multidisciplinary discussion teams review the case, according to Barbosa. (auntminnie.com)
  • If you're concerned that you might have an interstitial lung disease, the pulmonary care specialists in our Interstitial Lung Disease Program can help diagnose and treat your condition. (sutterhealth.org)
  • Interstitial lung disease (ILD) is a challenge to diagnose and treat. (uhhospitals.org)
  • University Hospitals offers cryobiopsy, a new technique used to diagnose interstitial lung disease. (uhhospitals.org)
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