Lung diseases. Medical search

Pathological processes involving any part of the LUNG.

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.

Tumors or cancer of the LUNG.

A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.

The transference of either one or both of the lungs from one human or animal to another.

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.

An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.

A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.

A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.

Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.

Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.

The volume of air that is exhaled by a maximal expiration following a maximal inspiration.

Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.

Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.

Measurement of volume of air inhaled or exhaled by the lung.

Infection of the lung often accompanied by inflammation.

The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.

A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.

Persistent abnormal dilatation of the bronchi.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.

Inhaling and exhaling the smoke of burning TOBACCO.

The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.

X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.

A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.

A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.

Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).

Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.

Pulmonary diseases caused by fungal infections, usually through hematogenous spread.

A human infant born before 37 weeks of GESTATION.

Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.

An infant during the first month after birth.

Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.

Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)

The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.

Endoscopic examination, therapy or surgery of the bronchi.

Difficult or labored breathing.

A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.

An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.

Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.

A pathological accumulation of air in tissues or organs.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.

Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.

Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.

Any hindrance to the passage of air into and out of the lungs.

The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).

Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)

Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.

A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.

The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.

Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.

Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.

Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)

The circulation of the BLOOD through the LUNGS.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

Agents that cause an increase in the expansion of a bronchus or bronchial tubes.

A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.

A malignant epithelial tumor with a glandular organization.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.

Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Diseases caused by factors involved in one's employment.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

An abnormal increase in the amount of oxygen in the tissues and organs.

The excision of lung tissue including partial or total lung lobectomy.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

The act of BREATHING out.

A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.

A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.

A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)

The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Inflammation of the BRONCHIOLES.

The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.

Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.

A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.

A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.

An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)

The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)

The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).

Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.

A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Drugs used for their effects on the respiratory system.

Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)

The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

Inflammation of the lung parenchyma that is caused by bacterial infections.

Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Granulomatous disorders affecting one or more sites in the respiratory tract.

Infections with bacteria of the genus PSEUDOMONAS.

Proteins found in the LUNG that act as PULMONARY SURFACTANTS.

Substances that reduce or suppress INFLAMMATION.

Any tests done on exhaled air.

An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Relatively complete absence of oxygen in one or more tissues.

Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.

Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.

The rate of airflow measured during a FORCED VITAL CAPACITY determination.

Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.

A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.

Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.

The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.

A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

An enzyme that activates histidine with its specific transfer RNA. EC 6.1.1.21.

Measurement of oxygen and carbon dioxide in the blood.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

MYCOBACTERIUM infections of the lung.

A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Endoscopic surgery of the pleural cavity performed with visualization via video transmission.

A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.

The structural changes in the number, mass, size and/or composition of the airway tissues.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

So-called atypical species of the genus MYCOBACTERIUM that do not cause tuberculosis. They are also called tuberculoid bacilli, i.e.: M. buruli, M. chelonae, M. duvalii, M. flavescens, M. fortuitum, M. gilvum, M. gordonae, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. kansasii, M. marinum, M. obuense, M. scrofulaceum, M. szulgai, M. terrae, M. ulcerans, M. xenopi.

The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.

The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.

The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.

Inflammation of a muscle or muscle tissue.

A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

The airflow rate measured during the first liter expired after the first 200 ml have been exhausted during a FORCED VITAL CAPACITY determination. Common abbreviations are MEFR, FEF 200-1200, and FEF 0.2-1.2.

Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.

A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.

A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.

A cell line derived from cultured tumor cells.

Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Radiography of the bronchial tree after injection of a contrast medium.

A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.

A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.

A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.

Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

Disease having a short and relatively severe course.

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. (1/5082)

OBJECTIVE: To evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role of the liver in the activation of alveolar macrophages. SUMMARY BACKGROUND DATA: Acute lung injury is the extrapancreatic complication most frequently associated with death and complications in severe AP. Neutrophil infiltration into the lungs seems to be related to the release of systemic and local mediators. The liver and alveolar macrophages are sources of mediators that have been suggested to participate in the lung damage associated with AP. METHODS: Pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. The inflammatory process in the lung and the activation of alveolar macrophages were investigated in animals with and without portocaval shunting 3 hours after AP induction. Alveolar macrophages were obtained by bronchoalveolar lavage. The generation of nitric oxide, leukotriene B4, tumor necrosis factor-alpha, and MIP-2 by alveolar macrophages and the chemotactic activity of supernatants of cultured macrophages were evaluated. RESULTS: Pancreatitis was associated with increased infiltration of neutrophils into the lungs 3 hours after induction. This effect was prevented by the portocaval shunt. Alveolar macrophages obtained after induction of pancreatitis generated increased levels of nitric oxide, tumor necrosis factor-alpha, and MIP-2, but not leukotriene B4. In addition, supernatants of these macrophages exhibited a chemotactic activity for neutrophils when instilled into the lungs of unmanipulated animals. All these effects were abolished when portocaval shunting was carried out before induction of pancreatitis. CONCLUSION: Lung damage induced by experimental AP is associated with alveolar macrophage activation. The liver mediates the alveolar macrophage activation in this experimental model. (+info)

The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease. (2/5082)

Alpha1 Protease inhibitor (alpha1PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate alpha1PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of patients with cystic fibrosis-associated lung disease who are infected with Pseudomonas aeruginosa. P. aeruginosa secretes pyocyanin, which, through its ability to redox cycle, induces cells to generate reactive oxygen species. We tested the hypothesis that redox cycling of pyocyanin could lead to inactivation of alpha1PI. When alpha1PI was exposed to NADH and pyocyanin, a combination that results in superoxide production, alpha1PI lost its ability to form an inhibitory complex with both porcine pancreatic elastase (PPE) and trypsin. Similarly, addition of pyocyanin to cultures of human airway epithelial cells to which alpha1PI was also added resulted in a loss of the ability of alpha1PI to form a complex with PPE or trypsin. Neither superoxide dismutase, catalase, nor dimethylthiourea nor depletion of the media of O2 to prevent formation of reactive oxygen species blocked pyocyanin-mediated inactivation of alpha1PI. These data raise the possibility that a direct interaction between reduced pyocyanin and alpha1PI is involved in the process. Consistent with this possibility, pretreatment of alpha1PI with the reducing agent beta-mercaptoethanol also inhibited binding of trypsin to alpha1PI. These data suggest that pyocyanin could contribute to lung injury in the P. aeruginosa-infected airway of cystic fibrosis patients by decreasing the ability of alpha1PI to control the local activity of serine proteases. (+info)

C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. (3/5082)

The anaphylatoxin derived from the fifth component of the human complement system (C5a) mediates its effects by binding to a single high-affinity receptor (C5aR/CD88), the expression of which has been traditionally thought to be restricted to granulocytes, monocytes, macrophages (Mphi), and cell lines of myeloid origin. Recent immunohistochemical data suggested that human bronchial and alveolar cells express C5aR as well. To reexamine the tissue distribution of human C5aR expression, transcription of the C5aR gene was investigated in normal and pathologically affected human lung (bronchopneumonia, tuberculosis), large intestine (acute appendicitis, Crohn's disease), and skin (pyogenic granuloma, lichen planus) using in situ hybridization. In contrast to previous evidence, C5aR mRNA could not be detected in pulmonary or intestinal epithelial cells, whereas keratinocytes in inflamed but not in normal skin revealed detectable levels of C5aR transcripts. Additionally, it could be documented that only migrating Mphi express C5aR mRNA, whereas sessile Mphi in normal tissues and epithelioid/multinucleated Mphi found in granulomatous lesions do not. Because C5a has been demonstrated to upregulate the expression of interleukin (IL)-6 in human monocytes, we also studied IL-6 gene transcription in parallel to the C5aR. IL-6 mRNA was detectable in many tissue Mphi. Surprisingly, a tight co-expression of C5aR and IL-6 mRNA was observed in keratinocytes from lesions of pyogenic granuloma and lichen planus. These results point to an as yet unknown role for C5a in the pathogenesis of skin disorders beyond its well-defined function as a chemoattractant and activator of leukocytes. (+info)

Mechanisms and mediators in coal dust induced toxicity: a review. (4/5082)

Chronic inhalation of coal dust can cause several lung disorders, including simple coal workers pneumoconiosis (CWP), progressive massive fibrosis (PMF), chronic bronchitis, lung function loss, and emphysema. This review focuses on the cellular actions and interactions of key inflammatory cells and target cells in coal dust toxicity and related lung disorders, i.e. macrophages and neutrophils, epithelial cells, and fibroblasts. Factors released from or affecting these cells are outlined in separate sections, i.e. (1) reactive oxygen species (ROS) and related antioxidant protection mechanisms, and (2) cytokines, growth factors and related proteins. Furthermore, (3) components of the extracellular matrix (ECM), including the modifying role of ROS, cytokines, proteases and antiproteases are discussed in relation to tissue damage and remodelling in the respiratory tract. It is recognised that inhaled coal dust particles are important non-cellular and cellular sources of ROS in the lung, and may be significantly involved in the damage of lung target cells as well as important macromolecules including alpha-1-antitrypsin and DNA. In vitro and in vivo studies with coal dusts showed the up-regulation of important leukocyte recruiting factors, e.g. Leukotriene-B4 (LTB4), Platelet Derived Growth Factor (PDGF), Monocyte Chemotactic Protein-1 (MCP-1), and Tumor Necrosis Factor-alpha (TNF alpha), as well as the neutrophil adhesion factor Intercellular Adhesion Molecule-1 (ICAM-1). Coal dust particles are also known to stimulate the (macrophage) production of various factors with potential capacity to modulate lung cells and/or extracellular matrix, including O2-., H2O2, and NO, fibroblast chemoattractants (e.g. Transforming Growth Factor-beta (TGF beta), PDGF, and fibronectin) and a number of factors that have been shown to stimulate and/or inhibit fibroblast growth or collagen production such as (TNF alpha, TGF beta, PDGF, Insulin Like Growth Factor, and Prostaglandin-E2). Further studies are needed to clarify the in vivo kinetics and relative impact of these factors. (+info)

Computed radiography dual energy subtraction: performance evaluation when detecting low-contrast lung nodules in an anthropomorphic phantom. (5/5082)

A dedicated chest computed radiography (CR) system has an option of energy subtraction (ES) acquisition. Two imaging plates, rather than one, are separated by a copper filter to give a high-energy and low-energy image. This study compares the diagnostic accuracy of conventional computed radiography to that of ES obtained with two radiographic techniques. One soft tissue only image was obtained at the conventional CR technique (s = 254) and the second was obtained at twice the radiation exposure (s = 131) to reduce noise. An anthropomorphic phantom with superimposed low-contrast lung nodules was imaged 53 times for each radiographic technique. Fifteen images had no nodules; 38 images had a total of 90 nodules placed on the phantom. Three chest radiologists read the three sets of images in a receiver operating characteristic (ROC) study. Significant differences in Az were only found between (1) the higher exposure energy subtracted images and the conventional dose energy subtracted images (P = .095, 90% confidence), and (2) the conventional CR and the energy subtracted image obtained at the same technique (P = .024, 98% confidence). As a result of this study, energy subtracted images cannot be substituted for conventional CR images when detecting low-contrast nodules, even when twice the exposure is used to obtain them. (+info)

Computerized analysis of abnormal asymmetry in digital chest radiographs: evaluation of potential utility. (6/5082)

The purpose of this study was to develop and test a computerized method for the fully automated analysis of abnormal asymmetry in digital posteroanterior (PA) chest radiographs. An automated lung segmentation method was used to identify the aerated lung regions in 600 chest radiographs. Minimal a priori lung morphology information was required for this gray-level thresholding-based segmentation. Consequently, segmentation was applicable to grossly abnormal cases. The relative areas of segmented right and left lung regions in each image were compared with the corresponding area distributions of normal images to determine the presence of abnormal asymmetry. Computerized diagnoses were compared with image ratings assigned by a radiologist. The ability of the automated method to distinguish normal from asymmetrically abnormal cases was evaluated by using receiver operating characteristic (ROC) analysis, which yielded an area under the ROC curve of 0.84. This automated method demonstrated promising performance in its ability to detect abnormal asymmetry in PA chest images. We believe this method could play a role in a picture archiving and communications (PACS) environment to immediately identify abnormal cases and to function as one component of a multifaceted computer-aided diagnostic scheme. (+info)

Lymphomatoid granulomatosis following autologous stem cell transplantation. (7/5082)

Lymphomatoid granulomatosis (LYG) is a rare angio-destructive lymphoproliferative disorder (LPD) of uncertain etiology, with prominent pulmonary involvement. Recent studies indicate that LYG is an Epstein-Barr virus (EBV)-associated B cell LPD with large numbers of background reactive T lymphocytes (T cell-rich B cell lymphoma). Although the disease frequently, but not exclusively, occurs in various immunodeficiency states, it has not been reported in association with the transient immunosuppression following autologous bone marrow/peripheral stem cell transplantation (ABM/PSCT). We describe a patient who developed lymphomatoid granulomatosis of the lung approximately 2 weeks after high-dose chemotherapy and autologous peripheral stem cell transplantation for multiple myeloma. Although molecular studies showed no evidence of EBV genome in the biopsy material, the serologic profile with high IgM titers was suggestive of primary EBV infection. Complete radiologic remission occurred following reconstitution of the patient's immune response after a 2-week course of ganciclovir treatment. Despite the apparently low frequency of LPD (both LYG and EBV-associated post-transplant lymphoma) in the ABMT setting, we believe that it should be considered in the differential diagnosis of patients whose clinical course following ABMT is complicated by fevers, in the absence of an identifiable infectious process. (+info)

Hexavalent chromium responsible for lung lesions induced by intratracheal instillation of chromium fumes in rats. (8/5082)

Lung toxicity of chromium fumes (Cr fumes) was examined by a single intratracheal instillation into rats of 10.6 mg and 21.3 mg Cr fumes/kg body weight and by repeated (3 times) instillations of 10.8 mg and 21.7 mg Cr fumes/kg. The pathological changes were compared with those induced by single administrations of 3.2 mg and 19.2 mg Na2CO3 solution-insoluble fraction of Cr fumes (Cr-Fr)/kg and 20.8 mg commercially available chromium (III) oxide powder (Cr (III) oxide)/kg. Single and repeated administrations of Cr fumes suppressed growth rate in a dose-dependent manner, but administrations of Cr-Fr and Cr (III) oxide did not. A single administration of Cr fumes produced granulomas in the entire airways and alveoli with progressive fibrotic changes, as well as severe mobilization and destruction of macrophages and foamy cells. Those histopathological changes were aggravated by the repeated administration of Cr fumes. On the other hand, single administrations of Cr-Fr and Cr (III) oxide produced no remarkable histopathological changes. Cr fumes were found to be composed of 73.5% chromium (III) oxide and 26.5% chromium (VI) oxide. The primary particles of Cr fumes and Cr-Fr were similar, 0.02 micron in size (sigma g: 1.25), and Cr (III) oxide particles were 0.30 micron in size (sigma g: 1.53), measured by analytical electron microscopy (ATEM). Diffuse clusters of the primary particles in Cr fumes were identified as Cr (VI) oxide. The present results suggested that the lung toxicity of Cr fumes was mainly caused by these Cr (VI) oxide (CrO3) particles in Cr fumes. (+info)

Inhalation of flock can cause flock worker's lung. Indium lung is an interstitial lung disease caused by occupational exposure ... "black lung disease", is an interstitial lung disease caused by long-term exposure (over 10 years) to coal dust. Symptoms ... interstitial lung diseases (such as pneumoconiosis, hypersensitivity pneumonitis, lung fibrosis), infections, lung cancer and ... Occupational lung diseases are work-related, lung conditions that have been caused or made worse by the materials a person is ...

https://en.wikipedia.org/wiki/Occupational_lung_disease

... may refer to: Asthma Bronchopulmonary dysplasia Chronic obstructive pulmonary disease, including chronic ... bronchitis and emphysema This disambiguation page lists articles associated with the title Chronic lung disease. If an internal ...

https://en.wikipedia.org/wiki/Chronic_lung_disease

Alveolar lung diseases, are a group of diseases that mainly affect the alveoli of the lungs. Alveoli are the functional units ... Alveolar lung disease may be divided into acute or chronic. Causes of acute alveolar lung disease include pulmonary edema ( ... A physician will listen to the patient's lungs to help determine if there is likely a lower lung disease. Depending on the type ... of alveolar lung disease, the listener may hear "crackles" that indicate an excess of fluid in the lungs or an absence of lung ...

https://en.wikipedia.org/wiki/Alveolar_lung_disease

... is characterized by reduced lung volumes, and therefore reduced lung compliance, either due to an ... Restrictive lung diseases are a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung ... "Restrictive Lung Disease". Retrieved 2008-04-19. "eMedicine - Restrictive Lung Disease : Article by Sat Sharma". Retrieved 2008 ... Mars 2009 eMedicine Specialties > Pulmonology > Interstitial Lung Diseases > Restrictive Lung Disease Author: Lalit K ...

https://en.wikipedia.org/wiki/Restrictive_lung_disease

... is a category of respiratory disease characterized by airway obstruction. Many obstructive diseases of ... Types of obstructive lung disease include; asthma, bronchiectasis, bronchitis and chronic obstructive pulmonary disease (COPD ... Cystic fibrosis is also sometimes included in obstructive pulmonary disease. Asthma is an obstructive lung disease where the ... Following is an overview of the main obstructive lung diseases. Chronic obstructive pulmonary disease is mainly a combination ...

https://en.wikipedia.org/wiki/Obstructive_lung_disease

... is a disease of the lung associated with RA, rheumatoid arthritis. Rheumatoid lung disease is ... "Lung Disease in Rheumatoid Arthritis". Medscape. Retrieved 20 February 2017. "Rheumatoid lung disease: MedlinePlus Medical ... which can distinguish rheumatoid lung disease from other interstitial lung diseases. The following tests may also show signs of ... Rheumatoid lung is separate from but often associated with Interstitial lung disease(ILD). Most common: Chest Pain Cough Fever ...

https://en.wikipedia.org/wiki/Rheumatoid_lung_disease

... is disease of the lungs caused by excessive alcohol. The term 'alcoholic lung disease' is not a ... Although lung damage from concurrent smoking and drug use is often indistinguishable from alcoholic lung disease, there is ... Recent research cites alcoholic lung disease as comparable to liver disease in alcohol-related mortality. Alcoholics have a ... The mechanisms of alcoholic lung disease are: Metabolism of alcohol reduces glutathione anti-oxidant levels in the lungs. ...

https://en.wikipedia.org/wiki/Alcoholic_lung_disease

... (ILD), or diffuse parenchymal lung disease (DPLD), is a group of respiratory diseases affecting the ... www.svhlunghealth.com.au/conditions/ild-interstitial-lung-disease. 20. ^"Interstitial Lung Disease: Symptoms, Causes, Tests and ... respiratory bronchiolitis associated interstitial lung disease, desquamative interstitial pneumonia, drug-induced lung diseases ... Whelan TP (March 2012). "Lung transplantation for interstitial lung disease". Clinics in Chest Medicine. 33 (1): 179-89. doi: ...

https://en.wikipedia.org/wiki/Interstitial_lung_disease

ISBN 978-3-030-23979-4. "Childhood Interstitial Lung Disease". National Heart, Lung, and Blood Institute. Retrieved 30 November ... "Interstitial lung diseases in children". Orphanet Journal of Rare Diseases. 5 (22). doi:10.1186/1750-1172-5-22. PMC 2939531. ... Childhood interstitial lung disease is a serious condition, with high morbidity and mortality. People with ChILD are at a ... Childhood interstitial lung disease, sometimes abbreviated as ChILD, is a family of rare chronic and complex disorders that ...

https://en.wikipedia.org/wiki/Childhood_interstitial_lung_disease

... is a tool in epidemiology that enables health care professionals to ... The Diseases Population Index for Lung Cancer Incidence: How it is Calculated and Applied, Meadowford Science Journal. ... The Diseases Population Index (DPI) also aids in decision making for setting priorities in health care settings. Currently, the ... For certain countries, the total number of cases of diseases is measured in millions. In this situation, the DPI provides an ...

https://en.wikipedia.org/wiki/The_Diseases_Population_Index_for_lung_cancer_incidence

... (GLILD) is a lung complication of common variable immunodeficiency ... The differential diagnosis includes infection, other interstitial lung diseases and malignant disease including lymphoma. ... and because some patients develop advanced lung disease, most specialists now recommend treatment in early disease, but this is ... Lung disease in primary antibody deficiency. Lancet Respir Med 2015;3:651-660 Schubert D, Bode C, Kenefeck R et al. Autosomal ...

https://en.wikipedia.org/wiki/Granulomatous–lymphocytic_interstitial_lung_disease

"History of The Union". International Union Against Tuberculosis and Lung Disease. Archived from the original on 10 March 2012. ... The International Union Against Tuberculosis and Lung Disease or The Union, is a global scientific organization headquartered ... The Union publishes two scientific journals; the International Journal of Tuberculosis and Lung Disease (IJTLD) and Public ... The Union organises the annual Union World Conference on Lung Health, the largest annual meeting on lung health in the world. ...

https://en.wikipedia.org/wiki/International_Union_Against_Tuberculosis_and_Lung_Disease

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) is a non-profit organization started by the World Health ... ISBN 978-1-4557-3812-0. v t e (All stub articles, Medical organization stubs, World Health Organization, Lung disease ... Al-Ruzzeh, Sharif; Kurup, Viji (2012-03-02). Marschall, Katherine (ed.). Stoelting's Anesthesia and Co-Existing Disease E-Book ... This organization issues recommendations for the treatment of chronic obstructive pulmonary disease and related medical ...

https://en.wikipedia.org/wiki/Global_Initiative_for_Chronic_Obstructive_Lung_Disease

Lloyd, Stacey (2006-11-08). "Why Cold Air Causes Breathing Difficulty in Lung Disease Patients". About: Lung Diseases. Archived ... The Centers for Disease Control and Prevention estimate that 1 in 11 children and 1 in 12 adults have asthma in the United ... In both people with asthma and people who are free of the disease, inhaled allergens that find their way to the inner airways ... Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed. John M. Miller, Douglas P. Zipes. "CHAPTER 33 - ...

https://en.wikipedia.org/wiki/Pathophysiology_of_asthma

PAM is one of the rare lung diseases currently being studied by the Rare Lung Diseases Consortium (RLDC). Pulmonary Alveolar ... Lung transplantation is an option for the end-stage disease but is typically only recommended as a last resort when the quality ... As the disease progresses, the lung fields become progressively more dense (white) on the chest xray, and low oxygen level, ... "Rare Lung Diseases > Learn More > Disorder Definitions". (Articles with short description, Short description is different from ...

https://en.wikipedia.org/wiki/Pulmonary_alveolar_microlithiasis

Miners developed a disproportionate amount of lung disease, eventually recognized as lung cancer in the 1870s. Despite this ... Lung cancer, also known as lung carcinoma (since about 98-99% of all lung cancers are carcinomas), is a malignant lung tumor ... list on each side Stage IIIA lung cancer Stage IIIB lung cancer Stage IIIB lung cancer Stage IV lung cancer Treatment for lung ... Diagrams of main features of staging Stage IA and IB lung cancer Stage IIA lung cancer Stage IIB lung cancer One option for ...

https://en.wikipedia.org/wiki/Lung_cancer

This resulted in 3.2 million deaths per year in 2020 and countless cases of stroke, heart disease, and lung cancer. Exposure to ... Gum disease has been linked to diseases such as cardiovascular disease. Diseases of poverty reflect the dynamic relationship ... These diseases produced in part by poverty are in contrast to diseases of affluence, which are diseases thought to be a result ... Diseases of poverty (also known as poverty-related diseases) are diseases that are more prevalent in low-income populations. ...

https://en.wikipedia.org/wiki/Diseases_of_poverty

A sarcoidosis-like lung disease called granulomatous-lymphocytic interstitial lung disease can be seen in patients with common ... Sarcoidosis of the lung is primarily an interstitial lung disease in which the inflammatory process involves the alveoli, small ... "Lung Diseases: Sarcoidosis: Signs & Symptoms". National Heart, Lung, and Blood Institute. Archived from the original on May 7, ... The disease usually begins in the lungs, skin, or lymph nodes. Less commonly affected are the eyes, liver, heart, and brain. ...

https://en.wikipedia.org/wiki/Sarcoidosis

... various lung diseases; 4) numerous drugs that chemically stimulate the hypothalamus; 5) inherited mutations; and 6) ... Multiple system atrophy Multiple sclerosis Cancers Carcinomas Lung cancers (small-cell lung cancer, mesothelioma) ... SIADH was originally described in 1957 in two people with small-cell carcinoma of the lung. Anorexia Nausea Muscle aches ... The condition was first described at separate institutions by William Schwartz and Frederic Bartter in two people with lung ...

https://en.wikipedia.org/wiki/Syndrome_of_inappropriate_antidiuretic_hormone_secretion

... (ESPD) is the result of chronic progressive lung diseases like COPD, idiopathic pulmonary fibrosis ... "End-Stage Lung Disease". 2016-02-02. Archived from the original on 2017-12-21. Retrieved 2017-12-21. v t e (Articles with short ... or systemic progressive diseases that affect the lungs such as cystic fibrosis or granulomatosis with polyangiitis. It is ... "Caregivers for people with end-stage lung disease: Characteristics and unmet needs in the whole population". International ...

https://en.wikipedia.org/wiki/End_stage_pulmonary_disease

... a serious lung sickness that can prompt inability and demise; Lung cancer; Constant obstructive pulmonary disease (COPD); and ... "Occupational Lung Diseases" (PDF). "CDC - Hierarchy of Controls - NIOSH Workplace Safety and Health Topic". www.cdc.gov. ... Without proper safety precautions, dust exposure can lead to occupational lung diseases. Dust particles are generated by the ... Alzheimer's disease has also been found as a result of exposure to high levels of manganese. Although, a link to Alzheimer's in ...

https://en.wikipedia.org/wiki/Occupational_dust_exposure

Norbert F. Voelkel; William MacNee (2002). Chronic Obstructive Lung Diseases. PMPH-USA. p. 380. ISBN 978-1-55009-133-5. ...

https://en.wikipedia.org/wiki/Rose_position

"Toxic Woods and Occupational Lung Diseases." Fine Art Photography. Riparia, 1 May 2000. Web. 11 Mar. 2010. Roux, Dr. J.P. " ...

https://en.wikipedia.org/wiki/Ptaeroxylon

... and Diffuse Lung Diseases. 26 (2): 121-131. PMC 2946799. PMID 20560292. Tong Z, Dai H, Chen B, Abdoh Z, Guzman J, Costabel U ( ... Legendre DP, Muzny CA, Swiatlo E (January 2012). "Hansen's disease (Leprosy): current and future pharmacotherapy and treatment ... Human studies have been conducted for Peyronie's disease. Pentoxifylline, in combination with tocopherol and clodronate, has ... is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It is generic and sold ...

https://en.wikipedia.org/wiki/Pentoxifylline

Vasculitis and Diffuse Lung Diseases. 19 (2): 120. PMID 12102607. Scadding JG (November 1999). "Jonathan Hutchinson and John ... His lectures on neuropathogenesis, gout, leprosy, diseases of the tongue, etc., were full of original observation; but his ... Wales AE (June 1963). "Sir Jonathan Hutchinson (1828-1913)". The British Journal of Venereal Diseases. 39 (2): 67-86. doi: ... Kampmeier RH (1977). "Prenatal syphilis and Sir Jonathan Hutchinson". Sexually Transmitted Diseases. 4 (4): 167-9. doi:10.1097/ ...

https://en.wikipedia.org/wiki/Jonathan_Hutchinson

... and Diffuse Lung Diseases. 36 (2): 141-147. doi:10.36141/svdld.v36i2.7620. PMC 7247107. PMID 32476947. Brömme D, Bonneau PR, ... Scientists have just announced that this enzyme predicts death, as it has been shown to be associated with both heart disease ... Wang H, Jiang H, Cheng XW (2022). "Cathepsin S are involved in human carotid atherosclerotic disease progression, mainly by ... is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study". The American Journal of Pathology. ...

https://en.wikipedia.org/wiki/Cathepsin_S

... cardiopulmonary disease; hypertension; skin lesions; and other lung and kidney diseases. Coal fires emit toxic levels of ... diseases like pneumoconiosis (black lung disease), bronchitis, emphysema, fibrosis, and cancer; generation of proinflammatory ... In the city of Lauro Müller in the state of Santa Catarina, studies show that respiratory diseases are responsible for an ... of oxidative stress conditions that may result in lung damage; potentially toxic accumulation of metals in body tissues; ...

https://en.wikipedia.org/wiki/Coal_mining_in_Brazil

"Rare Lung Diseases Disorder Definitions". www1.rarediseasesnetwork.org. Retrieved 13 November 2021. Maher 2011. Sudarshan et al ... 2006 Sep 28;25(44):5933-41 Bibliography Ayo, Dereje S.; Aughenbaugh, GL; Yi, ES; Hand, JL; Ryu, JH (2007), "Cystic Lung Disease ... Birt-Hogg-Dubé Syndrome patients, families, and caregivers are encouraged to join the NIH Rare Lung Diseases Consortium Contact ... "Genetic Interstitial Lung Disease", Clinics in Chest Medicine, 33 (1): 95-110, doi:10.1016/j.ccm.2011.11.001, PMC 3292740, PMID ...

https://en.wikipedia.org/wiki/Birt–Hogg–Dubé_syndrome

eMedicine Specialties > Pulmonology > Interstitial Lung Diseases > Restrictive Lung Disease Archived 5 March 2010 at the ... and interstitial lung diseases. Idiopathic pulmonary fibrosis (IPF), an interstitial lung disease of unknown cause, is most ... It is the main cause of restrictive lung disease that is intrinsic to the lung parenchyma. In contrast, quadriplegia and ... However, loss of pulmonary function is commonly ascribed to old age, heart disease or to more common lung diseases.[citation ...

https://en.wikipedia.org/wiki/Pulmonary_fibrosis

... and Diffuse Lung Diseases. 20 (3): 197-203. PMID 14620162. Fournière M, Latire T, Souak D, Feuilloley MG, Bedoux G (November ... Acne vulgaris is the disease most commonly associated with C. acnes infection. Acne vulgaris is a chronic inflammatory disease ... It is also suspected a main bacterial source of neuroinflammation in Alzheimer's disease brains. It is a common contaminant in ... Bhatia A, Maisonneuve JF, Persing DH (2004-01-01). Proprionibacterium acnes and Chronic Diseases. National Academies Press (US ...

https://en.wikipedia.org/wiki/Cutibacterium_acnes

Joseph Sargent, 89, American film director (The Taking of Pelham One Two Three, MacArthur, Jaws: The Revenge), heart disease. ... Dawn Sears, 53, American country musician (Nothin' but Good), lung cancer. Gerald Sim, 89, English actor (Gandhi, Patriot Games ... Rock Scully, 73, American band manager (Grateful Dead), lung cancer. Sultan Singh, 91, Indian politician, Governor of Tripura ( ... Frankie Randall, 76, American singer and actor, lung cancer. Lewis Rudolph, 95, American businessman, co-founder of Krispy ...

https://en.wikipedia.org/wiki/Deaths_in_December_2014

Chekhov died on 15 July 1904 at the age of 44 after a long fight with tuberculosis, the same disease that killed his brother. ... In March 1897, Chekhov suffered a major haemorrhage of the lungs while on a visit to Moscow. With great difficulty he was ... persuaded to enter a clinic, where the doctors diagnosed tuberculosis on the upper part of his lungs and ordered a change in ...

https://en.wikipedia.org/wiki/Anton_Chekhov

During the first wave, a growing abundance of evidence linked tobacco to death and disease. Individual smokers filed lawsuits ... The plaintiff Rolah McCabe, who was diagnosed with lung cancer, claimed British American Tobacco Australia misled her in ... During the second wave, plaintiffs charged tobacco companies with failure to warn about the addiction and disease risk of ... However, the tobacco industry responded by challenging the science of smoking causing disease and claiming that smokers assumed ...

https://en.wikipedia.org/wiki/Tobacco_politics

It sticks platelets together and promotes clotting; inhibiting this helps prevent heart disease. On the other hand, PTGS2 (COX- ... Saba N, Jain S, Khuri F (2004). "Chemoprevention in lung cancer". Curr Probl Cancer. 28 (5): 287-306. doi:10.1016/j. ... Minghetti L, Pocchiari M (2007). "Cyclooxygenase‐2, Prostaglandin E2, and Microglial Activation in Prion Diseases". ... Mechanisms of COX-2 inhibitor risk to heart disease". Life Sciences. 88 (1-2): 24-30. doi:10.1016/j.lfs.2010.10.017. PMC ...

https://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase_2

In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere. Symptoms of advanced cervical cancer may ... Dunne EF, Park IU (December 2013). "HPV and HPV-associated diseases". Infectious Disease Clinics of North America. 27 (4): 765- ... Papillomavirus-associated diseases, Sexually transmitted diseases and infections, Wikipedia medicine articles ready to ... Screening is not beneficial before age 25, as the rate of disease is low. Screening is not beneficial in women older than 60 ...

https://en.wikipedia.org/wiki/Cervical_cancer

... which had formed itself in his lungs, suddenly burst, and discharged a quantity of matter, which he continued to throw up while ... Infectious disease deaths in Pennsylvania, Les Neuf Sœurs, Masonic Grand Masters, Members of the American Philosophical Society ... Respiratory disease deaths in Pennsylvania, Rhetoric theorists, Scientists from Boston, Scientists from Philadelphia, Signers ... time apart is that he may have blamed her for possibly preventing their son Francis from being inoculated against the disease ...

https://en.wikipedia.org/wiki/Benjamin_Franklin

Nachtigal contracted a lung disease and relocated to Annaba in Algeria in October, 1862. He travelled to Tunis in 1863, where ...

https://en.wikipedia.org/wiki/Gustav_Nachtigal

By the mid-1950s there was a scientific consensus that smoking promotes lung cancer, but the tobacco industry fought the ... weekly Centers for Disease Control scientific reports and attempted to silence the government's most senior infectious disease ... to the Advisory Committee to the director of the Centers for Disease Control. According to the report, information about ... and researched alternate explanations for lung cancer, such as pollution, asbestos and even pet birds. Denying the case against ...

https://en.wikipedia.org/wiki/Politicization_of_science

Believed to have contracted it from a contaminated needle, she became one of the first famous women to die of the disease. Her ... After her agent, mentor, and friend Wilhelmina Cooper, died of lung cancer in March 1980, a devastated Carangi began using ... becoming one of the first famous women to die of the disease. Her funeral was held on November 23 at a small funeral home in ...

https://en.wikipedia.org/wiki/Gia_Carangi

Their eldest child died in 2005 of lung disease. Among those who visited the remains were Prime Minister, Datuk Seri Najib ...

https://en.wikipedia.org/wiki/Mazlan_Nordin

The yeast was characterized as "an opportunist pathogen for lung transplant and/or CF patients". Because of its resistance, it ... Animal fungal diseases). ...

https://en.wikipedia.org/wiki/Candida_blankii

His disease caused his muscles to atrophy, so he eventually needed a catheter and colostomy bag ... as well as surgery on his ... larynx to keep saliva from filling his lungs."[unreliable source?] The transformations were shown in a Channel 4 documentary, ... He had motor neurone disease and was known for his efforts to extend his life by becoming what he called a human cyborg. In ... From 2018, Scott-Morgan was a trustee of the Motor Neurone Disease Association. He and his husband also set up a foundation, " ...

https://en.wikipedia.org/wiki/Peter_Scott-Morgan

... and lung vessels while pulmonary aplasia has complete absence of lung tissue and lung vessels, but have some incompletely ... So, there is a considerable time delay for the disease to be diagnosed, though it's capable of detection since birth or even ... On the other hand, the hypertrophy of the remaining lung to compensate for the lost lung is common in the case of unilateral ... Either one side of the lung fails completely, leading to pulmonary aplasia, or one side of the lung is underdeveloped, leading ...

https://en.wikipedia.org/wiki/Pulmonary_agenesis

1 to lung and 1 to bone. By the end of the study, 47 individuals had no evidence of disease and 2 had died of unknown causes. ... In a study of 25 individuals with EPC, 14 had in situ and 11 had invasive disease with 6 of the invasive tumors rated as high ... In a study of 25 individuals with EPC, 14 had in situ and 11 had invasive disease with 6 of the invasive tumors rated as high ... In a follow-up 8 to 104 months (mean: 47 months) after diagnoses of 29 cases, 5 developed recurrent disease 1.5 to 7 (mean: 3.3 ...

https://en.wikipedia.org/wiki/Papillary_carcinomas_of_the_breast

Sakorn suffered from lung disease and kidney failure and had been admitted to Kasemrad Rattanathibet Hospital on 9 May. He was ... Deaths from lung cancer, Deaths from kidney failure, Deaths from cancer in Thailand, Thai traditional performing artists). ...

https://en.wikipedia.org/wiki/Sakorn_Yang-keawsot

To combat the disease, he underwent an extremely rare heart-liver transplant on the morning of June 14, 1993 at the University ... Lung transplant recipients, Pennsylvania Auditors General, Pennsylvania Democrats, Pennsylvania lawyers, Pennsylvania state ... Though rare, the disease had also claimed the lives of Pittsburgh Mayor Richard Caliguiri and Erie Mayor Louis Tullio in 1988 ... The announcement of Casey's disease was made just days before he underwent the transplant, and as a result many accused him of ...

https://en.wikipedia.org/wiki/Bob_Casey_Sr.

... diseases and can serve as clinical markers of disease severity and/or as therapeutic targets for controlling the diseases. ... lung, and cervix express low levels of, or no, CMTM5-v1 and concurrently have highly methylated CpG sites near to the CMTM5 ... On the other hand, the CpG cluster(s) controlling the CMTM5 gene in the blood of individuals with the autoimmune disease of ... Liu TF, Lin T, Ren LH, Li GP, Peng JJ (December 2020). "[Association between CMTM5 gene and coronary artery disease and the ...

https://en.wikipedia.org/wiki/CKLF-like_MARVEL_transmembrane_domain-containing_5

"Identification of genes associated with non-small-cell lung cancer promotion and progression". Lung Cancer. 67 (2): 151-9. doi: ... "Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease". Nature ...

https://en.wikipedia.org/wiki/SLC2A13

The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. ... of pulmonary fibrosis Clinical trial center for idiopathic pulmonary fibrosis Functional and structural imaging of the lung ... procedural therapies for asthma and COPD Mechanisms of airway hyperresponsiveness and airway remodelling Trafficking and lung ...

https://en.wikipedia.org/wiki/Firestone_Institute_for_Respiratory_Health

Hypoxic damage can also occur to most of the infant's organs (heart, lungs, liver, gut, kidneys), but brain damage is of most ... The U.S. Centers for Disease Control and Prevention (CDC) has led an initiative to improve woman's health previous to ... The pregnant woman may then find breathing easier, since her lungs have more room for expansion, but pressure on her bladder ... Martin RJ, Fanaroff AA, Walsh MC (2014). Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. ...

https://en.wikipedia.org/wiki/Childbirth

The SRCC tumor is often seen in the peritoneum and has also been known to spread to lymphatic permeation of the lungs and to ... SRCC cancers are usually diagnosed during the late stages of the disease, so the tumors generally spread more aggressively than ... SRCCs do not normally form in the lungs, though a few instances have been reported.[1] Among colorectal cancers, the prevalence ... ISBN 978-1-60831-434-8. "Office of Rare Diseases Research: Diffuse Gastric Cancer". National Institute of Health. National ...

https://en.wikipedia.org/wiki/Signet_ring_cell_carcinoma

In 1992, the foundation took the name of Provincial Hospital of Tuberculosis and Lung Diseases. In 2000, the hospital received ... At that time, the medical ensemble encompassed three facilities: the Provincial Tuberculosis and Lung Diseases Clinic at 11 ... In 1949, the infectious diseases ward was moved to the Hospital for Infectious Diseases at 10 Świętego Floriana Street and the ... together with the Rehabilitation Department and the Tuberculosis and Lung Diseases Department (in 2004). In 2003, the ...

https://en.wikipedia.org/wiki/Seminaryjna_Street

The horse's respiratory system consists of the nostrils, pharynx, larynx, trachea, diaphragm, and lungs. Additionally, the ... Diseases and surgery of the globe and orbit". In Gilger, BC (ed.). Equine Ophthalmology (3rd ed.). John Wiley & Sons. p. 151. ...

https://en.wikipedia.org/wiki/Equine_anatomy

The Ant Mosaic - Tropical Tree Crops and the Limiting of Pests and Diseases. PANS Pest Articles & News Summaries. 19 (3): 311- ... He died while working in Florida, from lung cancer. Leston, Pendergrast & Southwood. 1954. Classification of the Terrestrial ...

https://en.wikipedia.org/wiki/Dennis_Leston

... other than non-small cell lung cancer and thyroid cancer) with disease progression on or following prior systemic treatment or ... The conversion to regular approval for non-small cell lung cancer (NSCLC) was based on data from an additional 172 participants ... "FDA approves selpercatinib for lung and thyroid cancers with RET gene". U.S. Food and Drug Administration (FDA). 8 May 2020. ... "FDA Approves First Therapy for Patients with Lung and Thyroid Cancers with a Certain Genetic Mutation or Fusion" (Press release ...

https://en.wikipedia.org/wiki/Selpercatinib

F. D. Kendall, who examined her on the morning of June 9, 1893, noted that her heart and lungs appeared to be fine, but that ... "complications of diseases" being the cause of death listed on her death certificate.: 123 Amanda America Dickson Toomer's ... or Beard's disease. Symptoms of neurasthenia, as described by nineteenth-century physicians, include "sick headache, noises in ...

https://en.wikipedia.org/wiki/Amanda_America_Dickson

This etiology is called ectopic or paraneoplastic Cushing's disease and is seen in diseases such as small cell lung cancer. ... While all Cushing's disease gives Cushing's syndrome, not all Cushing's syndrome is due to Cushing's disease. Several possible ... Cushing's disease is rare; a Danish study found an incidence of less than one case per million people per year. However, ... Cushing's disease is a specific type of Cushing's syndrome caused by a pituitary tumor leading to excessive production of ACTH ...

https://en.wikipedia.org/wiki/Cushing's_syndrome

RIG-G has shown the capacity to inhibit NF-κB and STAT3 signaling in lung cancer cells, which demonstrates the potential of ... Delayed IFN-I response contributes to the pathogenic inflammation (cytokine storm) seen in later stages of COVID-19 disease. ... Bhatti Z, Berenson CS (February 2007). "Adult systemic cat scratch disease associated with therapy for hepatitis C". BMC ... Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. ...

https://en.wikipedia.org/wiki/Interferon

Delahunty was a guest worker at the National Institute of Diabetes and Digestive and Kidney Diseases in the diabetes branch. At ... Henneberger died in September 2006 due to lung cancer. American men & women of science : a biographical directory of today's ...

https://en.wikipedia.org/wiki/George_Delahunty

... then for venereal disease sufferers from 1792, and closed and demolished in 1949 Royal Hospital Kilmainham in Dublin, a 1684 ... a specialist heart and lung hospital, located on the Cambridge Biomedical Campus in Cambridge, England, originally founded in ... Devon Royal National Hospital for Rheumatic Diseases, a specialist rheumatology hospital in Bath, Somerset, founded in 1742 ...

https://en.wikipedia.org/wiki/Royal_Hospital

Health Information on Lung Diseases: MedlinePlus Multiple Languages Collection ... Lung Diseases: MedlinePlus Health Topic - English Enfermedades de los pulmones: Tema de salud de MedlinePlus - español (Spanish ... URL of this page: https://medlineplus.gov/languages/lungdiseases.html Other topics A-Z. ...

https://medlineplus.gov/languages/lungdiseases.html

Major Occupational Lung Diseases. Pneumoconioses. Silicosis. Silicosis refers to a spectrum of lung diseases caused by ... 3). Depending on the stage and severity of disease, resting lung function abnormalities may include reduced lung volumes and ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... chronic kidney disease, chronic airflow obstruction (including emphysema and chronic bronchitis), and lung infections from ...

https://www.cdc.gov/niosh/learning/b-reader/clinical/lung/1.html

Attendees heard a fascinating story of how disease detectives unraveled the mystery of popcorn-lung disease, and how we can ... Not Everything Is Better with Butter-flavoring: Popcorn Lung Disease and the Dangers of Diacetyl ... "We Were There" - Diacetyl and Popcorn Lung Disease. ... Popcorn Lung Disease and the Dangers of Diacetyl," at the ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...

https://www.cdc.gov/os/wewerethere/diacetyl/index.html

Family history of lung cancer. People with a parent, sibling or child with lung cancer have an increased risk of the disease. ... Lung cancer. Lung cancer. Lung cancer begins in the cells of your lungs. ... Lung cancer is a type of cancer that begins in the lungs. Your lungs are two spongy organs in your chest that take in oxygen ... Non-small cell lung cancer. Non-small cell lung cancer is an umbrella term for several types of lung cancers. Non-small cell ...

https://www.mayoclinic.org/diseases-conditions/lung-cancer/symptoms-causes/syc-20374620

Unlike obstructive lung diseases, including asthma and COPD, which show a normal or increased total lung capacity (TLC), ... either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular ... Restrictive lung diseases are characterized by reduced lung volumes, ... A lung biopsy is not always required to make a diagnosis in patients suggestive of having iingnterstitial lung diseases. A lung ...

https://www.medscape.com/answers/301760-187982/what-is-the-role-of-lab-studies-in-the-evaluation-of-extrinsic-lung-disease-causes-of-restrictive-lung-disease

Tags blood diseases, heart diseases, HLBS-PopOmics, lung diseases, public health genomics knowledge base, sleep disorders, ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... HLBS-PopOmics: NHLBI and CDC partner to launch a public health genomics knowledge base for heart, lung, blood, and sleep ...

https://blogs.cdc.gov/genomics/tag/lung-diseases/

Interstitial lung disease (ILD) is a group of disorders that lead to scarring (fibrosis) and inflammation in the lung tissue. ... It affects the space around the small air sacs of the lung. Other parts of the lungs may be affected as these diseases worsen. ... The Lung Association. http://www.lung.ca. REFERENCES:. Behr J. Approach to the diagnosis of interstitial lung disease. Clin ... Interstitial lung disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/interstitial-lung-disease. ...

http://healthlibrary.epnet.com/GetContent.aspx?token=3e5dbc25-ab4e-4419-a847-31a4e7a92e96&chunkiid=908003

Browsing 059th session: Manila, 22-26 September 2008 by Subject "Lung Diseases". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N ... Noncommunicable disease prevention and control (‎Resolution)‎ Regional Committee for the Western Pacific, 059 (‎WHO Regional ...

https://apps.who.int/iris/handle/10665/137584/browse?authority=Lung+Diseases&type=mesh

Pulmonary rehabilitation is a tool that is receiving more acceptance in chronic lung diseases. A retrospective study was made ... Noncommunicable disease prevention and control (‎Resolution)‎ Regional Committee for the Western Pacific, 059 (‎WHO Regional ... Practical approach to lung health : manual initiating PAL implementation World Health Organization (‎World Health ... Hereditary Diseases Programme; Joint WHO/ICF(‎MA Task Force on Cystic Fibrosis (‎1990 : Leningrad/Moscow, USSR)‎ (‎World Health ...

https://extranet.who.int/iris/restricted/browse?authority=Lung+Diseases&type=mesh

Cancer and Chronic Lung Disease in the Workplace ... Cancer and Chronic Lung Disease in the Workplace U.S Department ... NATIONAL CTR FOR CHRONIC DISEASE PREVENTION & HLTH PROM CDC (NCCPDPD). 4770 Buford Hwy, NE MS:(K-50). Chamblee, GA 30341. This ...

https://wonder.cdc.gov/wonder/prevguid/p0000057/p0000057.asp

Hyperacidification in cystic fibrosis: links with lung disease and new prospects for treatment. Trends Mol Med. 2002;8:512-9. ... Acetobacter indonesiensis Pneumonia after Lung Transplant. Emerging Infectious Diseases. 2008;14(6):997-998. doi:10.3201/ ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...

https://wwwnc.cdc.gov/eid/article/14/6/07-1236_article

Unlike obstructive lung diseases, including asthma and COPD, which show a normal or increased total lung capacity (TLC), ... either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular ... Restrictive lung diseases are characterized by reduced lung volumes, ... Approach to the evaluation and diagnosis of interstitial lung disease. Interstitial Lung Disease. 4th ed. London: BC Decker Inc ...

https://emedicine.medscape.com/article/301760-medication

Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France. Emerging Infectious Diseases. 2023;29(2):286-293. doi: ... Hirschi S, Biondini D, Ohana M, Solis M, DUrso A, Rosner V, et al. Herpes simplex virus 2 hepatitis in a lung transplant ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The environment and disease: association or causation? Proc R Soc Med. 1965;58:295-300. DOIPubMedGoogle Scholar ...

https://wwwnc.cdc.gov/eid/article/29/2/22-1468

Work-Related Lung Disease Surveillance System (eWoRLD). Sources of Data. Address and Employment Data, MSHA. Address and ... "dust diseases of the lungs" and "respiratory conditions due to toxic agents" after 2001. Since 2002, BLS combined these ... as for surviving spouses of coal miners whose death resulted from the disease or who were entitled to Black Lung benefits at ... "Dust diseases of the lungs" (pneumoconioses) includes silicosis, asbestosis, coal workers pneumoconiosis, byssinosis, ...

http://www2a.cdc.gov/drds/WorldReportData/html/SourcesOfData.asp

Lung problems, from pneumonia to COPD, range from mild to severe. WebMDs health center guides you to answers about symptoms, ... Lung Disease & Respiratory Health Resource Center. Tools and resources to help understand and manage a range of lung conditions ... How NTM MAC, a Lung Disease, Affects the Body Most of us can breathe in MAC, a bacteria found in soil and water, and never get ... An Inside Look at How Pneumonia Affects Your Lungs Pneumonia is an infection of the air sacs in your lungs. Its usually mild ...

https://www.webmd.com/lung/default.htm

... when dust leads to inflammation and scarring in the lungs. Silicosis and asbestos-related lung disease have also been ... CDC Investigating Why Dentists Have Come Down with Deadly Lung Disease. By Matt Berger - Updated on December 7, 2018 ... Acting on a tip from a dentist getting treatment for the lung disease at a Virginia clinic, the CDC found nine other dental ... While the report is worrying, outside experts said the risk of developing lung disease is likely lower for those working in ...

https://www.healthline.com/health-news/cdc-investigating-dentists-with-lung-disease

Nontuberculous Mycobacteria-associated Lung Disease in Hospitalized Persons, United States, 1998-2005 Megan E. Billinger, ... Nontuberculous Mycobacteria-associated Lung Disease in Hospitalized Persons, United States, 1998-2005. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...

https://wwwnc.cdc.gov/eid/content/15/10/1562-t2.htm

... treatment and diagnostic testing for children with pulmonary disease. Learn more about our specialty offerings. ... Ranked #2 in Pediatric Lung Disease Care. If your child has been diagnosed with a lung condition or pediatric lung disease, we ... Specifically, our Pediatric Lung Transplant Program is one of the few in the country capable of performing transplants for ... All our teams work together with one goal in mind: to provide the best possible evaluation and treatment of your childs lung ...

https://www.cincinnatichildrens.org/service/p/pulmonary

The cotton workers had a larger loss of lung function as measured by forced expiratory volume in ... The relationship between long term exposure to cotton dust and associated gram negative bacterial endotoxin on lung function ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...

https://www.cdc.gov/niosh/nioshtic-2/00235386.html

Chronic, nonmalignant, noninfectious diseases. *Lower respiratory tract disease. *Distal lung parenchyma disease ...

https://fpnotebook.com/mobile/Lung/ILD/IntrstlLngDs.htm

Progressive Fibrosing Interstitial Lung Disease * Fast Five Quiz: Progressive Fibrosing Interstitial Lung Disease Presentation ... Fast Five Quiz: Rheumatoid Arthritis Interstitial Lung Disease Management * Fast Five Quiz: Interstitial Nonidiopathic ... Fast Five Quiz: Interstitial Lung Disease Progressive Fibrosing Management * Fast Five Quiz: ... Fast Five Quiz: Interstitial Lung Disease Progressive Fibrosing Management - Medscape - Mar 06, 2023. ...

https://reference.medscape.com/viewarticle/946212_5

... of THC vapers say the marijuana they use is safe while half say they havent changed their habits since word of the lung ... Marijuana News: New Survey Says Lung Disease Not Discouraging Vapers. By Marcy Kreiter @marcykreiter 12/18/19 AT 2:22 PM. ... THC vapers say the marijuana they use is safe while half say they havent changed their habits since word of the lung disease ... vape marijuana are still confident their products are safe despite the deaths of more than four dozen people from lung disease ...

https://www.ibtimes.com/marijuana-news-new-survey-says-lung-disease-not-discouraging-vapers-2887467

Coal workers pneumoconiosis or Black Lung is a work-related lung disease caused by breathing in coal mine dust. ... Black Lung disease). This means that prevention of exposure and early detection of disease are the most effective means of ... avoiding symptomatic Black Lung Disease. If a person is diagnosed with coal workers pneumoconiosis treatment is typically ... For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our ...

https://www.nationaljewish.org/conditions/coal-workers-pneumoconiosis-black-lung-disease/treatment

One of the worst offenders is particulate matter, or fine dust, which when inhaled, tends to lodge deeply in the lungs, making ... Recently, new reports on air pollution and disease have surfaced, providing more evidence that air quality may affect us even ... them vulnerable to respiratory problems and others diseases like cancer. According to this story, the "average concentration of ...

https://blogs.edf.org/texascleanairmatters/tag/lung-disease/

The gut-lung axis postulates that alterations in gut microbial communities may have a profound effect on lung disease. ... The gut-lung axis postulates that alterations in gut microbial communities may have a profound effect on lung disease. ... In this review, we summarize studies describing the role of the microbiome in interstitial lung disease and discuss the ... This paper describes the impact of the microbial communities on the pathogenesis of lung diseases by assessing recent original ...

https://www.frontiersin.org/articles/10.3389/fmed.2021.595522/full

... ... Health Program list of 9/11-related health conditions has grown to include many chronic diseases such as lung diseases (e.g., ... interstitial lung diseases, reactive airways dysfunction syndrome (RADS), sleep apnea, chronic obstructive pulmonary disease ( ... Secondly, there is need to bolster research in environmental health and chronic disease. What exactly have the toxins in the ...

https://www.forbes.com/sites/brucelee/2016/09/11/continuing-911-legacy-lung-disease-cancer-mental-health-conditions-and-other-diseases/

Lung cancer kills more women and men than the other top three cancer killers combined. ... The American Lung Association is working to save lives by improving lung health and preventing lung disease. Saturday, more ... Lung cancer kills more women and men than the other top three cancer killers combined. ...

https://www.kivitv.com/news/fight-for-air-climb

Directory. Start here to access encyclopedic information about the worm genome and its genes, proteins, and other encoded features… Find out more. ...

https://wormbase.org/resources/disease/DOID:14453

Vaccines are one of the safest ways for you to prevent disease. Being vaccinated, quitting smoking and managing your chronic ... Vaccination provides the best protection against vaccine preventable diseases. ... have a greater risk of getting seriously ill from diseases that vaccines prevent. Vaccinations are an important measure to keep ... People with chronic lung disease, like asthma or COPD, ... People with chronic lung disease, like asthma or COPD, have a ...

https://www.lung.ca/vaccinations

People with chronic lung disease, like asthma or COPD, have a greater risk of getting seriously ill from diseases that vaccines prevent. (lung.ca)
People with chronic lung diseases, such as asthma, COPD, or cystic fibrosis, are at increased risk of complications of influenza and pneumococcal infection. (lung.ca)
On May 9-11, 2011 NIH held an international workshop on the "Health Burden of Indoor Air Pollution on Women and Children," in Arlington, VA. To gather information on the knowledge base on this topic and identify research gaps, ahead of the meeting we conducted a literature search using PubMed to identify publications that related to HAP, asthma, and chronic obstructive pulmonary disease (COPD). (nih.gov)
We also discuss emerging data to suggest ways in which abnormal lymphatic function contributes to diseases in the lung, such as COPD and ILD. (thoracic.org)
He said quarrying, cement factories, charcoal burning and related activities were adding to the toll of patients with Chronic Obstructive Pulmonary Disease (COPD). (greaterkashmir.com)
It is basically the PM 2.5 that is clouding heart health," he said, adding that surveys had found Kashmir having a higher incidence of both COPD and heart disease than many parts of India. (greaterkashmir.com)
COPD is an obstructive lung disease that makes it hard to breathe . (lung.org)
However, close to 24 million adults were estimated to have impaired lung function, suggesting under-diagnosis of COPD. (cdc.gov)
Although often thought of as a disease caused by cigarette smoking, it is well-recognized that COPD is also caused by occupational exposures. (cdc.gov)
Joining us to share the important cause that will be supported by the 2020 Fight for Air Climb are Rachel Wiesner, a Fight for Air co-chair who climbs in memory of her mom who died from lung cancer, and Mandy Reilly, who climbs in honor of her mom who died from COPD. (tmj4.com)
Unlike obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), which show a normal or increased total lung capacity (TLC), restrictive disease are associated with a decreased TLC. (medscape.com)
These investigators focused on the implications of smoking and the development of pulmonary abnormalities other than chronic obstructive pulmonary disease (COPD). (medscape.com)
Herein, we review the main pathways of pulmonary cells metabolism and the relationship between changes in cell metabolism and the four lung diseases of chronic obstructive pulmonary disease ( COPD ), asthma , idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension ( PH ), to find new ways to treat lung diseases . (bvsalud.org)
The campaign was created to raise awareness and to eventually eliminate COPD, also known as Chronic Obstructive Pulmonary Disease. (teneightymagazine.com)
COPD occurs when your lungs have been exposed to something harmful for a long enough period of time as to cause permanent damage, and is usually caused by smoking, exposure to air pollution or by inhaling dust or fumes at work. (teneightymagazine.com)
COPD is long term and results in the narrowing of your lungs' airways, obstructing the passage of air and making it difficult to breathe. (teneightymagazine.com)
It has been reported that asthmatic and COPD (chronic obstructive pulmonary diseases) patients struggle to use their inhalers correctly. (aerosol-soc.com)
This study aims to primarily answer the question: ?where does or does not chronic obstructive lung disease (COPD) and asthma arise, persist and progress in the UK? (ukbiobank.ac.uk)
We plan to study the relationship of the built environment and respiratory outcomes (COPD & asthma), meeting the UK Biobank?s stated purpose of improving the prevention, diagnosis and treatment of a serious, high-burden disease in the UK. (ukbiobank.ac.uk)
This study aims to primarily answer the question: "where does or does not chronic obstructive lung disease (COPD) and asthma arise, persist and progress in the UK", describing location in detail through measurable attributes of the built environment in which subjects reside. (ukbiobank.ac.uk)
These NCDs include cardiovascular diseases (e.g. hypertension, heart attack and stroke), diabetes, chronic respiratory disease (e.g. chronic obstructed pulmonary disease or COPD,) and cancer. (who.int)
Macrolides have pleomorphic effects in the lung with improvement in pulmonary function, symptoms and inflammatory markers demonstrated in several inflammatory pulmonary conditions such as cystic fibrosis, asthma, COPD and post-transplant bronchiolitis obliterans. (clinicaltrials.gov)
We are frequently contacted by North Carolinians wondering if breathing problems like chronic obstructive pulmonary disease ("COPD"), asthma, or cystic fibrosis can qualify them to receive Social Security Disability benefits. (justicecounts.com)
The purpose of this guideline is to maximise the safety of patients with chronic obstructive pulmonary disease (COPD) during the COVID-19 pandemic, while protecting staff from infection. (bvsalud.org)

As there are two pneumonia vaccines, some people with chronic lung disease, including asthma may require two different vaccines to obtain better protection. (lung.ca)
The microDMx sensor is able to identify molecules that may be the cause of lung diseases such as cancer, asthma and chronic obstructive pulmonary disease caused by smoking. (biologynews.net)
For instance, if a patient is taking steroids for asthma, we would be able determine whether they were being given the right amount of steroids from the molecules in their breath which relate to the severity of the inflammation in their lungs. (biologynews.net)
What is unique about this sensor, and the use of the microDMx technology, is the fact that it can be configured to not just analyse one disease or condition, but it has the potential to be used to analyse a broad spectrum of conditions from asthma, to cancer and metabolic disorders such as diabetes," says Dr Thomas. (biologynews.net)
Funded by some of the highest levels of outside grants in the country, faculty are making notable contributions in areas of pulmonary hypertension treatment, lung transplantation, drug-free asthma treatments and mucus-blocking therapies, among others. (barnesjewish.org)
People recovering from COVID-19 with a history of lung disease, including asthma or chronic obstructive pulmonary disorder, or who had lower levels of a particular antibody in the first week of diagnosis, took longer than their peers to experience a complete resolution of their symptoms, according to a new Stanford Medicine study. (stanford.edu)
Our finding that the levels of antibody to a specific viral protein within one week of diagnosis correlate with the time to complete resolution of symptoms is one of the first to identify a possible biomarker that can be assessed early to predict the course of the disease," said Kari Nadeau , MD, PhD, who directs the Sean N. Parker Center for Allergy and Asthma Research at Stanford Medicine. (stanford.edu)
Asthma is a chronic lung disease that makes it harder to move air in and out of your lungs-otherwise known as "breathing. (lung.org)
Reports have linked work-related styrene exposure to asthma and an irreversible lung disease known as obliterative bronchiolitis. (cbia.com)
Asthma is an inflammatory airways disease causing episodic, reversible airways obstruction. (cdc.gov)
People with heart disease, asthma, emphysema, or … health effects occurring depends mostly on the concentration of air pollutants in people's breathing zone (the air around the nose and mouth). (wisconsin.gov)
This will enable us to conduct research exploring prospective associations between built environment, air pollution and incident respiratory mortality and respiratory health (including asthma, respiratory allergies, acute upper and local respiratory infections, influenza and pneumonia, lung disease, lung cancer). (ukbiobank.ac.uk)
Asthma can be a serious and frustrating disease to deal with and while there are many medications that will help treat the symptoms, the best way to avoid an asthma attack is to avoid whatever triggers it. (webpronews.com)
Asthma is a disease characterized by periods when the sufferer has a hard time breathing or getting enough oxygen. (webpronews.com)
These short-lived gases contribute to cancer, asthma, and other heard and lung diseases. (rcinet.ca)
An expert on asthma and airway disease, he leads a TB research programme with Viet Nam's National TB Programme. (theunion.org)
In some cases, your child may need tests to rule out other diseases, such as pneumonia or asthma. (ahealthyme.com)

Excessive silica exposure is associated with an increased risk for lung cancer, autoimmune disorders (including rheumatoid arthritis, systemic sclerosis and increased serum autoantibodies), chronic kidney disease, chronic airflow obstruction (including emphysema and chronic bronchitis), and lung infections from mycobacteria and some fungal species. (cdc.gov)
Lung cancer begins in the cells of your lungs. (mayoclinic.org)
Lung cancer is a type of cancer that begins in the lungs. (mayoclinic.org)
Lung cancer is the leading cause of cancer deaths worldwide. (mayoclinic.org)
People who smoke have the greatest risk of lung cancer, though lung cancer can also occur in people who have never smoked. (mayoclinic.org)
The risk of lung cancer increases with the length of time and number of cigarettes you've smoked. (mayoclinic.org)
If you quit smoking, even after smoking for many years, you can significantly reduce your chances of developing lung cancer. (mayoclinic.org)
Lung cancer typically doesn't cause signs and symptoms in its earliest stages. (mayoclinic.org)
Signs and symptoms of lung cancer typically occur when the disease is advanced. (mayoclinic.org)
But lung cancer also occurs in people who never smoked and in those who never had prolonged exposure to secondhand smoke. (mayoclinic.org)
In these cases, there may be no clear cause of lung cancer. (mayoclinic.org)
Doctors believe smoking causes lung cancer by damaging the cells that line the lungs. (mayoclinic.org)
When you inhale cigarette smoke, which is full of cancer-causing substances (carcinogens), changes in the lung tissue begin almost immediately. (mayoclinic.org)
Doctors divide lung cancer into two major types based on the appearance of lung cancer cells under the microscope. (mayoclinic.org)
Your doctor makes treatment decisions based on which major type of lung cancer you have. (mayoclinic.org)
Small cell lung cancer. (mayoclinic.org)
Small cell lung cancer occurs almost exclusively in heavy smokers and is less common than non-small cell lung cancer. (mayoclinic.org)
Non-small cell lung cancer. (mayoclinic.org)
Non-small cell lung cancer is an umbrella term for several types of lung cancers. (mayoclinic.org)
A number of factors may increase your risk of lung cancer. (mayoclinic.org)
One of the worst offenders is particulate matter, or fine dust, which when inhaled, tends to lodge deeply in the lungs, making them vulnerable to respiratory problems and others diseases like cancer. (edf.org)
Lung cancer kills more women and men than the other top three cancer killers combined. (kivitv.com)
NEW YORK - Researchers at the National Cancer Institute, Georgetown University, and Walter Reed National Military Medical Center have determined that small cell lung cancer (SCLC), a disease which is currently thought to result almost entirely from exposure to tobacco, may have an inherited predisposition. (genomeweb.com)
Further, they said, unselected patients with SCLC were more likely to carry germline RAD51D, CHEK1, BRCA2, and MUTYH pathogenic variants than healthy controls, and germline genotype was significantly associated with the likelihood of a first-degree relative with cancer or lung cancer, as well as longer recurrence-free survival after platinum-based chemotherapy. (genomeweb.com)
In addition to containing varying levels of the addictive substance nicotine, they also contain other cancer-causing chemicals, such as formaldehyde, and as our study shows, flavoring chemicals that can cause lung damage. (ktnv.com)
BOSTON - Lung cancer patients with a specific genetic alteration lived longer and were protected against metastasis to the brain when treated early with the drug lorlatinib (Lorbrena), according to a study led by researchers at Massachusetts General Hospital (MGH), published in the New England Journal of Medicine ( NEJM ). (massgeneral.org)
Non-small-cell lung cancer (NSCLC) accounts for 87% of all cases of lung cancer. (massgeneral.org)
ALK-positive NSCLC, which is not associated with smoking, is a particularly aggressive form of lung cancer. (massgeneral.org)
Notably, ALK-positive patients tend to be 10 to 15 years younger than other lung cancer patients. (massgeneral.org)
Case No. 1, man with an almost hopeless case of Hodgkin's disease (cancer of the lymph glands) who was completely incapacitated. (healingcancernaturally.com)
Case No. 3, a man who had lung cancer . (healingcancernaturally.com)
On March 5th 1971 he was put on the operating table where they found lung cancer so widely spread that it was inoperable. (healingcancernaturally.com)
Compare Lung cancer healed or improved thanks to flaxoil and cottage cheese (center part of Dr. Johanna Budwig diet) and Stage 4 lung cancer healing thanks to aloe & honey syrup . (healingcancernaturally.com)
Learn about Siteman Cancer Center's treatment approach for lung cancer patients. (barnesjewish.org)
More people die from lung cancer than any other type of cancer. (lung.org)
it's responsible for close to 90% of lung cancer cases. (lung.org)
A new prospective study of more than 500 adults who were current smokers when diagnosed with lung cancer, published today in the Annals of Internal Medicine , provides robust evidence indicating that quitting smoking after diagnosis of lung cancer is associated with significant improvement in overall survival and disease-free survival among these patients. (who.int)
This study recruited 517 patients with newly diagnosed non-small cell lung cancer who were current smokers, from the departments of thoracic surgery at two sites in Moscow, Russian Federation, and followed them up annually for an average of 7 years to record any changes in their smoking behaviour and disease status. (who.int)
Postdiagnosis smoking cessation and reduced risk for lung cancer progression and mortality: a prospective cohort study. (who.int)
News and reporting on lung cancer. (genomeweb.com)
Agilent's companion diagnostic for Mirati's non-small cell lung cancer treatment Krazati will be available through Quest's national healthcare network. (genomeweb.com)
Researchers conducted an immunogenomic analysis of brain metastases from individuals with primary lung or breast cancer. (genomeweb.com)
Your tax-deductible donation funds lung disease and lung cancer research, new treatments, lung health education, and more. (lung.org)
Consequently, cancer, neurodegenerative diseases or developmental disorders may arise. (mpg.de)
And then I lost my mom to lung cancer and my dad to heart disease. (crainsnewyork.com)
It increases the rate of coronary heart disease, stroke and lung cancer and contributes to many other health issues. (uvm.edu)
secondhand smoke contains about 70 cancer-causing chemicals and leads to nearly 42,000 premature deaths from heart disease and lung cancer each year in the United States, the CDC says. (uvm.edu)
Alex Becker explique pourquoi le Selwyn House Rock Band souhaitait appuyer la recherche sur le cancer en jouant au Théâtre Corona le 16 novembre. (buzzsprout.com)
There are 11 teams who are performing and fundraising for causes close to their hearts, from cancer to cardiology to rare genetic diseases. (buzzsprout.com)

Four of the eight workers were ill and put on lung transplant waiting lists. (cdc.gov)
People with severe symptoms and those who are not helped by these methods may need a lung transplant . (epnet.com)
In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. (cdc.gov)
Clinical and laboratory data over time for a heart-lung transplant patient in France who had cytolytic hepatitis caused by HCirV-1 develop. (cdc.gov)
The patient had received a heart-lung transplant 17 years earlier because of Eisenmenger syndrome related to ventricular septal defect. (cdc.gov)
Specifically, our Pediatric Lung Transplant Program is one of the few in the country capable of performing transplants for infants as small as 11 pounds . (cincinnatichildrens.org)
On some occasions lung transplant becomes necessary. (nationaljewish.org)
Knowing the underlying genetic cause and identifying other patients with the same genetic problem can help us better predict the course of the disease, so we can better prepare patients and their families for what is to come, such as whether the patient may respond to treatments, or worsen to needing a lung transplant, or whether it may be appropriate to begin discussing compassionate care. (rtmagazine.com)
Read more about our internationally known Transplant program that performs over 50 lung transplants every year. (barnesjewish.org)
Taj, who requires a double lung transplant and suffers from pulmonary fibrosis, ripped off his oxygen mask and raised his voice. (electronicintifada.net)
Doctors told him that his only chance of survival was a lung transplant. (electronicintifada.net)
The patient was transferred to the tertiary care hospital in which we practice in Boston, where she ultimately underwent a bilateral lung transplant from a high-risk donor without induction immunosuppression. (cdc.gov)

Lower-zone predominance is seen in patients with idiopathic pulmonary fibrosis (IPF), asbestosis, or collagen-vascular diseases. (medscape.com)
Chest radiograph of a 67-year-old man diagnosed with idiopathic pulmonary fibrosis, based on open lung biopsy findings. (medscape.com)
Researchers at the Centers for Disease Control and Prevention (CDC) are trying to uncover why a cluster of dentists were diagnosed with a rare lung disease called idiopathic pulmonary fibrosis (IPF) . (healthline.com)
Chronic fibrosing ILD with a progressive phenotype encompasses a group of fibrotic lung diseases caused by different underlying diseases or conditions, including autoimmune ILD, hypersensitivity pneumonitis and idiopathic nonspecific interstitial pneumonia. (fda.gov)
The characteristics were also noted in a small percentage of lung cells provided by people living with idiopathic pulmonary fibrosis (IPF), another rare lung disease. (nih.gov)
The second part describes common ILDs like idiopathic interstitial pneumonias, sarcoidosis, and hypersensitivity pneumonitis as well as ILDs associated with connective tissue diseases or induced by exposure to environmental agents, drugs, and radiation. (novapublishers.com)
Idiopathic pulmonary fibrosis is the most common type of interstitial lung disease, accounting for 20% of all the cases. (verywellhealth.com)
Wang J … Segal LN. Lung microbiome and host immune tone in subjects with idiopathic pulmonary fibrosis treated with inhaled interferon- γ . (nyu.edu)
They include idiopathic fibrotic diseases, connective-tissue diseases, drug-induced lung disease, environmental exposures (inorganic and organic dusts), and primary diseases of the lungs (including sarcoidosis). (medscape.com)
Some of these patients may have had an early form of idiopathic pulmonary fibrosis (IPF), or this may have been an initial stage of IPF where tobacco either fuels the process of lung injury and repair or is important as a necessary but insufficient sole step in the development of IPF. (medscape.com)
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. (medscape.com)
The purpose of this guideline is to maximise the safety of adults with interstitial lung disease, including idiopathic pulmonary fibrosis and pulmonary sarcoidosis, during the COVID-19 pandemic. (bvsalud.org)

The diagnosis of an interstitial lung disorder is often initially based on abnormal chest radiograph findings, although they can be normal in as many as 10% of patients. (medscape.com)
The presence of bilateral cysts and nodules, with preservation of lung volumes, may suggest a diagnosis of lymphangioleiomyomatosis (LAM) or pulmonary Langerhans cell histiocytosis. (medscape.com)
A sample of lung tissue may be taken to confirm the diagnosis. (epnet.com)
Behr J. Approach to the diagnosis of interstitial lung disease. (epnet.com)
Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008. (medscape.com)
In this review, we summarize studies describing the role of the microbiome in interstitial lung disease and discuss the implications of these findings on the diagnosis and treatment of these diseases. (frontiersin.org)
Under Part 22.4 of the State Sanitary Code, every physician, health care facility and clinical laboratory in attendance on the person with clinical evidence of occupational lung disease shall report such occurrence to the New York State Department of Health within 10 days of diagnosis. (ny.gov)
This book highlights recent advances in the understanding of interstitial lung disease (ILD) from diagnosis to treatment. (novapublishers.com)
There are patients with a clinical diagnosis of interstitial lung disease without a genetic explanation. (rtmagazine.com)
While the diagnosis was not able to help the patient in this case, knowledge of the underlying cause allowed the parents to know that the genetic variant was not inherited and there would be a very low chance of future children having the same disease. (rtmagazine.com)
The HLVI Center for Rare Diseases and Conditions is committed to establishing a strong foundation for research, diagnosis and treatment of the most complex, rare conditions of the heart, and lungs, and vascular system. (uc.edu)
NYU Langone's Division of Pulmonary, Critical Care, and Sleep Medicine conducts multidisciplinary research on interstitial lung diseases to improve the diagnosis and advance patient care of these complex conditions. (nyu.edu)
Our research in advanced interstitial lung diseases is focused on expanding available information, therapies, and regional networks to improve the diagnosis of these disorders. (nyu.edu)
Accurate detection of diffuse lung disease is an important step for computerized diagnosis and quantification of this disease. (nih.gov)
Our computerized scheme would be useful for assisting radiologists in the diagnosis of diffuse lung disease. (nih.gov)
This work provided a glimpse into the working environment, including health and safety practices, before mines reported a diagnosis of lung disease within their workforce. (cdc.gov)
Similarly, underground miners were approximately 3 times more likely than surface miners to report a diagnosis of lung disease. (cdc.gov)
We will draw applications to how urban and environmental choices impact those who suffer from respiratory disease, and assist health professionals to improve diagnosis, counseling and health maintenance for their patients. (ukbiobank.ac.uk)

Canadians with existing lung disease are more likely to become severely ill from pneumonia. (lung.ca)
Biomedical engineers at the Massachusetts Institute of Technology have developed a synthetic biosensor using specialized nanoparticles to detect and then report the presence of molecules indicating bacterial pneumonia or the genetic disease alpha-1 antitrypsin deficiency. (statnews.com)
We report a case of Acetobacter indonesiensis pneumonia in a 51-year-old woman after bilateral lung transplantation. (cdc.gov)

Silicosis refers to a spectrum of lung diseases caused by inhalation of free crystalline silica. (cdc.gov)
Chronic complicated silicosis, or progressive massive fibrosis (PMF), is characterized by nodular lung lesions of one centimeter or greater in diameter, usually in the upper lung zones on chest radiograph and CT ( Fig. 3 ). (cdc.gov)
Silicosis, like all of the occupational pneumoconioses, is a preventable disease. (cdc.gov)
Silicosis and asbestos-related lung disease have also been identified in dentists. (healthline.com)
Inhaling dusts that contain crystalline forms of silica can cause a fibrosing interstitial lung disease called silicosis. (cdc.gov)

Predictors of mortality and progression in scleroderma-associated interstitial lung disease: a systematic review. (medscape.com)
Characterizing the composition of the lung microbiome during disease and elucidating the contribution of the dysbiotic microbiome to disease progression is an area of active research for many respiratory ailments, including ILDs. (frontiersin.org)
Characteristics of chronic fibrosing ILD include lung scarring and rapid disease progression, as assessed through worsening lung function tests, symptoms and/or imaging. (fda.gov)
They also recommend studying and will continue to follow the role lymphatics may have in disease progression, which could support the development of new and improved therapies. (nih.gov)
We found that patients who received nintedanib had a slower rate of progression of interstitial lung disease than those who received placebo,' the authors write. (healthday.com)
In addition, Pseudomonas aeruginosa and an altered microbiome might contribute to local inflammation and disease progression. (lww.com)
We are also developing clinical trials to prevent progression and induce regression of lung fibrosis resulting from COVID-19-related acute lung injury and acute respiratory distress syndrome, funded by the National Institute of Allergy and Infectious Diseases. (nyu.edu)
Progression of fibrosing ILD is primarily reflected in a decline in lung function, worsening of symptoms, and deterioration in health-related quality of life. (medscape.com)
Studies have shown that a reduced FVC may be the most reliable risk factor for disease progression in patients with PF-ILD. (medscape.com)
Although the FVC can vary greatly on a daily basis in patients with IPF, higher FVC variability may also be associated with disease progression. (medscape.com)
Radiologic markers may predict disease progression in patients with PF-ILD. (medscape.com)
Finally, several blood biomarkers have been investigated as predictors of disease progression in patients with fibrosing ILDs, including Krebs von den Lungen-6 protein (KL-6). (medscape.com)

Interstitial lung disease (ILD) is a group of disorders that lead to scarring (fibrosis) and inflammation in the lung tissue. (epnet.com)
Microbial imbalance or dysbiosis in the gut microbiome is associated with illness and disorders, including interstitial lung diseases (ILDs) ( 7 - 10 ). (frontiersin.org)
ILDs, otherwise called diffuse parenchymal lung diseases, are a group of disorders characterized by chronic inflammation that result in fibrosis (scarring) of the lung ( 13 ). (frontiersin.org)
NHLBI is the global leader in conducting and supporting research in heart, lung, and blood diseases and sleep disorders that advances scientific knowledge, improves public health, and saves lives. (nih.gov)
Most disorders of the interstitium thicken lung tissues with scarring, inflammation, and fluid. (verywellhealth.com)
The American Thoracic Society improves global health by advancing research, patient care, and public health in pulmonary disease, critical illness, and sleep disorders. (thoracic.org)
While there are cardiovascular and pulmonary-related diseases and conditions that are common and highly prevalent in the United States, there are also an increasing number of previously considered rare disorders requiring attention. (uc.edu)
If caused by parenchymal lung disease, restrictive lung disorders are accompanied by reduced gas transfer, which may be marked clinically by desaturation after exercise. (medscape.com)
The many disorders that cause reduction or restriction of lung volumes may be divided into two groups based on anatomical structures. (medscape.com)
The second is extrinsic disorders or extrapulmonary diseases. (medscape.com)
Diseases of these structures result in lung restriction, impaired ventilatory function, and respiratory failure (eg, nonmuscular diseases of the chest wall, neuromuscular disorders). (medscape.com)
What diseases or disorders affect the trachea? (kembrel.com)

After infection has resolved, they clear the cellular debris remaining [ 10 ] and aid in the remodelling of the lung parenchyma. (hindawi.com)
For each VOI, we determined and employed statistical texture features, such as run-length and co-occurrence matrix features, to distinguish abnormal from normal lung parenchyma. (nih.gov)
Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. (medscape.com)
The first is intrinsic lung diseases or diseases of the lung parenchyma. (medscape.com)
In a cohort that was very well described in terms of their smoking behavior (that included about 2400 patients), the authors found that approximately 8% of patients, or about 1 in 11, had abnormal findings in their parenchyma in terms of potential interstitial lung disease (ILD) related to their smoking. (medscape.com)

The goal of treatment is to manage symptoms, slow the disease, and improve quality of life. (epnet.com)
Symptoms of interstitial lung disease may get worse with time. (verywellhealth.com)
People with lower levels of an antiviral antibody as well as those with lung disease take longer to clear COVID-19 symptoms, say Stanford Medicine researchers. (stanford.edu)
Understanding workplace factors that contribute to lung disease is complicated because symptoms of dust-induced lung disease often take years to become apparent. (cdc.gov)
Disease activity was assessed using 46 assays across five key domains: symptoms, lung physiology, structural changes on CT, pulmonary and systemic inflammatory markers. (ox.ac.uk)
Many people with Paget's disease do not have symptoms. (nih.gov)

Researchers have discovered new insights about lymphangioleiomyomatosis (LAM), a rare lung disease, which affects about 1 in 200,000 Americans and commonly features the growth of abnormal cells in different tissues and organs, including the lungs. (nih.gov)
Two radiologists selected 31 normal and 37 abnormal CT scans with ground glass opacity, reticular, honeycombing and nodular disease patterns based on clinical reports. (nih.gov)
It wasn't as if having "dirty lungs" and abnormal findings on your high-resolution CT translated into a predictable loss in lung volume. (medscape.com)

Available at: https://www.blf.org.uk/support-for-you/interstitial-lung-disease-ild. (epnet.com)
Interstitial lung disease (ILD) includes more than 200 conditions that cause inflammation and scarring of lung tissue. (verywellhealth.com)

Spirometry findings showed a severe restrictive lung disease, with a forced expiratory volume in one second of 0.4 L/s and a forced vital capacity of 0.5 L. (medscape.com)
Canadians with chronic lung disease may be more likely to experience severe illness, including hospitalization due to COVID-19. (lung.ca)
For the subsets that are going to progress to have more severe lung disease, that subset is lower. (ajmc.com)
In 1 particular cohort of diffuse cutaneous disease-there are about 1000 patients in this particular cohort-about 16% of these patients developed pretty severe interstitial lung disease with this restrictive lung physiology on pulmonary function testing with an FVC [forced vital capacity] less than 55% that developed really severe lung disease or interstitial progressive interstitial lung disease in scleroderma. (ajmc.com)
MADISON - So far during July of 2019, eight cases of severe pulmonary disease among adolescents were reported to the Wisconsin Department of Health Services (DHS). (thebrillionnews.com)
With the recent resurgence of the most severe form of black lung disease among coal miners, especially in central Appalachia, understanding and preventing exposure to the respirable, or inhalable, dust generated during the extraction of coal is paramount. (cdc.gov)
Breaks and rearrangements in the genome can lead to severe diseases, even if all genes remain intact. (mpg.de)
But Kaitlyn is a special needs student who has a severe pulmonary hypertension and chronic lung disease. (opednews.com)
Emerging evidence shows that severe coronavirus disease 2019 (COVID-19) can be complicated by a significant coagulopathy, that likely manifests in the form of both microthrombosis and VTE. (bvsalud.org)

Cystic fibrosis could be considered two diseases, one that affects multiple organs including the lungs, and one that doesn't affect the lungs at all, according to a multicenter team led by researchers at the University of Pittsburgh School of Medicine. (pitt.edu)
The research, published online in PLOS Genetics , showed that nine variants in the gene associated with cystic fibrosis can lead to pancreatitis, sinusitis, and male infertility, but leave the lungs unharmed. (pitt.edu)
Mutations in the gene can lead to dysfunctional CFTR channels and thick, sticky secretions, causing problems such as the chronic lung congestion associated with cystic fibrosis. (pitt.edu)
Previously in cystic fibrosis research, other kinds of mutations of CFTR were deemed harmless because they didn't cause lung problems, Whitcomb noted, but the Pitt-led study looked more closely at that notion. (pitt.edu)
In addition, the identification will spur the launch of trials to determine if medications used by cystic fibrosis patients might have some benefit for those who do not have lung disease, but who carry the other mutations. (pitt.edu)
Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. (ox.ac.uk)

Bronchiectasis and obstructive lung diseases in primary anti. (lww.com)

An elevated creatine kinase level may indicate myositis, which may cause muscle weakness with resultant restrictive lung disease. (medscape.com)
Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease. (medscape.com)
Seif NE, ELbadawy AM. Comparative study of mid-thoracic spinal versus epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease: A randomized controlled study. (medscape.com)
The mnemonic "PAINT" has been used to divide the causes of restrictive lung disease into pleural, alveolar, interstitial, neuromuscular, and thoracic cage abnormalities. (medscape.com)
Restrictive lung diseases are characterized by a reduction in FRC and other lung volumes because of pathology in the lungs, pleura, or structures of the thoracic cage. (medscape.com)

Medical monitoring of at-risk workers using chest radiographs and spirometry may help with early detection of those at risk for worsening lung disease with ongoing exposure. (cdc.gov)
Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale. (mayoclinic.org)
The effect on lungs of people in areas with higher ambient air suspended particles was also a concern, Dr Naveed Nazir Shah, head department of Chest Medicine at GMC Srinagar said. (greaterkashmir.com)
The volume of FRC is determined by the balance of the inward elastic recoil of the lungs and the outward elastic recoil of the chest wall. (medscape.com)
This suggests that the phenomenon many of us in pulmonary medicine have seen in our clinical practice -- where we examine patients who are otherwise asymptomatic smokers, and they've had a CT scan or a chest x-ray for some reason that was not related to a pulmonary issue, and they were found to have what we always classified as "dirty lungs" when I was in training. (medscape.com)
In addition to studying these critical areas, NIOSH administers the Coal Workers' Health Surveillance Program , a federally mandated screening and surveillance program which provides chest X-rays and lung-function testing at no cost to eligible miners nationwide. (cdc.gov)
Pulmonary complications, namely acute chest syndrome, obstructive lung disease and pulmonary hypertension, are the most common causes of death in patients with SCA. (clinicaltrials.gov)

Injury or illness can cause inflammation in the lungs and airways. (epnet.com)
these result in bystander damage to lung architecture, influx of immune cells to the airways, and consequent impairment of gas exchange. (hindawi.com)
The distinct environment of the lung, with high oxygen tension [ 1 ] and constant exposure to inhaled antigen, both harmful and harmless, presents challenges for the immune cells which patrol the airways. (hindawi.com)
This rare lung disease causes scar tissue and inflammation in the small airways, which eventually makes it difficult to breathe. (cbia.com)
It's when your child has swelling in the smaller airways (bronchioles) of the lung. (ahealthyme.com)

The potential for development of interstitial lung disease in systemic sclerosis is relatively high. (ajmc.com)
We talk with Dr. El-Chemaly about his research in this field, including his work on the role of lymphangiogenesis in the development of interstitial lung diseases. (thoracic.org)

All types of interstitial lung disease affect the interstitium, a system of tissues running through the lungs. (verywellhealth.com)
However, it is best known for causing coal workers' pneumoconiosis (CWP), a type of lung disease affecting the tissues and gas-exchange surface of the lung (interstitial lung disease). (cdc.gov)
As the place for gas exchange, the lungs are metabolically active, and their energy consumption are essential for regulating common cell functions and maintaining the unique function of lung tissues to synthesize pulmonary surfactants . (bvsalud.org)
And there is plenty of common ground between ACE2 and apelin, including the fact that many cell types and tissues have both, including the lungs. (prohealth.com)
In people with autoimmune diseases, the immune cells attack the body's own healthy tissues by mistake, instead of viruses or bacteria. (nih.gov)

Over time, the excess tissue that is built leads to fibrosis in the lungs. (epnet.com)
This makes it hard for oxygen to pass from the lung tissue to the blood vessels in the lungs. (epnet.com)
However, immune cells must be able to respond rapidly to a genuine threat and, once it is dealt with, resolve any resulting inflammation and remodel any damage to the lung tissue. (hindawi.com)
During early influenza infection, airway epithelial cells produce CCL2 [ 15 ] (MCP-1), which attracts CCR2 + monocytes into the lung tissue from the blood [ 3 ]. (hindawi.com)
Also caused by autoimmune diseases and connective tissue conditions, this type of ILD leads to inflammation and/or scarring of the lungs. (verywellhealth.com)
This ILD condition can be caused by exposure to asbestos and leads to scar tissue on the lungs and inflammation of the lungs. (verywellhealth.com)
This is a type of ILD that causes scar tissue buildup in the lungs. (verywellhealth.com)
A genetic variant in a surfactant-producing protein led to a fatal case of pediatric interstitial lung disease in a two-year-old child, according to an analysis of the child's lung tissue published in the Proceedings of the National Academy of Sciences . (rtmagazine.com)
The lung tissue from the child had evidence of a problem with surfactant in the lungs. (rtmagazine.com)
The diseases cause inflammation or scarring of the lung tissue (interstitial lung disease) or result in filling of the air spaces with exudate and debris (pneumonitis). (medscape.com)
It was dramatic in both directions," says Dr. Babak Baban, DCG immunologist and associate dean for research, of shifting apelin levels in both circulating blood and lung tissue. (prohealth.com)
Apelin is a pervasive peptide made by cells in the heart, lung, brain, fat tissue and blood, and is an important regulator in bringing both blood pressure and inflammation down, says Baban, the study's corresponding author. (prohealth.com)
But when they looked at their ARDS model, apelin didn't do either, and instead decreased in both the lung tissue itself and the general circulation. (prohealth.com)
IPF (n=117), FIP (n=54), iNSIP (n=34), NSIP secondary to connective tissue disease (NSIP_CTD, n=32) and a healthy subjects cohort (n=249) were genotyped for MUC5B rs35705950. (ersjournals.com)

It's an irreversible respiratory condition that causes the tiny air sacs in the lungs to become scarred. (ktnv.com)
"Popcorn Lung," otherwise known as bronchiolitis obliterans, causes scarring in tiny air sacs in the lungs that lead to excessive coughing and shortness of breath. (ktnv.com)
What are tiny sacs in the lungs? (kembrel.com)

However, recent advances in microbial sequencing techniques suggest that a variety of microbial organisms dwell in both the upper and lower respiratory tract and that composition of this microbial community is altered in respiratory disease states ( 12 ). (frontiersin.org)
Division of Respiratory Disease Studies. (cdc.gov)
Especially in view of the increasing use of coal as an energy source and the predicted growth of coal mining, protecting coal miners from respiratory disease continues to be an important and ongoing priority. (cdc.gov)
and 70 patients without respiratory disease (control group), ranging between 19 and 69 years of ages, with a mean age of 41.3, and standard deviation of 13.6 years. (bvsalud.org)
She also provides specialized care for patients with nasal polyposis and aspirin-exacerbated respiratory disease, in collaboration with Yale and other community otolaryngologists. (ynhh.org)

Therapy is best prescribed in consultation with a pulmonary disease specialist. (medscape.com)
Here, we focus on recent findings in obstructive pulmonary disease and bronchiectasis in PAD. (lww.com)
Despite its high global burden, there is an extreme paucity of data on chronic obstructive pulmonary disease in PAD. (lww.com)
Chronic obstructive pulmonary disease refers to chronic bronchitis, emphysema, and combined presentations of these two diseases. (cdc.gov)
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality in the United States and world-wide. (cdc.gov)

However, anemia can indicate vasculitis, polycythemia can indicate hypoxemia in advanced disease, and leukocytosis can suggest acute hypersensitivity pneumonitis. (medscape.com)
She had received pulse steroids 16 months before the hepatitis occurred to treat acute lung allograft dysfunction. (cdc.gov)
The purpose of this guideline is to help healthcare professionals who are not cardiology specialists identify and treat acute myocardial injury and its cardiac complications in adults with known or suspected COVID-19 but without known pre-existing cardiovascular disease. (bvsalud.org)

Other parts of the lungs may be affected as these diseases worsen. (epnet.com)
In the case of IPF, inhaling those particles can sometimes, eventually, lead to a thickening of parts of the lungs. (healthline.com)

We developed a computerized scheme to assist radiologists in the detection of diffuse lung disease in multi-detector computed tomography (CT). (nih.gov)
We investigated the impact of new and conventional texture features, VOI size and the dimensionality for regions of interest on detecting diffuse lung disease. (nih.gov)

This is a lung infection affecting the interstitium. (verywellhealth.com)
The disease severity of the remaining 578 ranged from mild to critical, and 351 were hospitalized as a result of their infection. (stanford.edu)
Earlier and improved tuberculosis (TB) case detection - including smear-negative disease, often associated with HIV co-infection - as well as expanded capacity to diagnose multidrug-resistant tuberculosis (MDR-TB) are global priorities for TB control. (who.int)
Now they have shown that apelin levels go way down with the viral infection, which has killed 1 million people worldwide, and that CBD quickly helps normalize those levels along with lung function. (prohealth.com)
we don't know yet about causative, but it is a very good indicator of the disease," Baban says of the bottom line impact of the viral infection on apelin levels. (prohealth.com)
Bronchiolitis is an infection of the lungs. (ahealthyme.com)

Occupational lung diseases / W. Keith C. Morgan, Anthony Seaton. (who.int)
The author concludes that radiologic procedures provide valuable diagnostic tools for the evaluation of dust related occupational lung diseases. (cdc.gov)

and chronic inflammatory diseases like rheumatoid arthritis ( 16 ). (frontiersin.org)
in rheumatoid lung disease (4 cases) significantly fewer macrophages (45 +/- 5) were seen and 12 cases with methyl isocyanate exposure showed insignificant changes. (who.int)
Although the overall rheumatoid arthritis-related mortality rates have been decreasing in recent years, rates of mortality among patients with rheumatoid arthritis-associated interstitial lung disease remain stable. (rheumatologyadvisor.com)
Although the overall rheumatoid arthritis-related mortality rates have been decreasing in recent years, rates of mortality among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remain stable, except for in patients aged 65 to 84 years, for whom outcomes have improved, according to findings published in the Annals of the American Thoracic Society . (rheumatologyadvisor.com)
Jeganathan N, Nguyen E, Sathananthan M. Rheumatoid arthritis and associated-interstitial lung disease: mortality rates and trends . (rheumatologyadvisor.com)

Lung transplantation may be an option for patients with progressive respiratory failure. (cdc.gov)
On January 25, 2007, a 31-year-old man with CF (mutation ΔF 508 and I 507) was admitted to our institution in Marseille, France, for lung transplantation. (cdc.gov)

Results of search for 'ccl=Provider:International Union against Tuberculosis and Lung Disease. (who.int)
It presents the Union (International Union Against Tuberculosis and Lung Disease) mission, activities, structure, history, conferences, courses and brings information about tuberculosis and lung. (bvsalud.org)

The number of mysterious cases of lung disease in Pennsylvania and around the nation continues to increase. (qrglaw.com)
Next, the investigators looked at the effects of safety and health enforcement from 1996-2005 on later cases of lung disease from 2006-2015. (cdc.gov)
Focusing on regulations governing management practices and engineering controls, or tools, to control dust, they found that mines that did a better job of complying with these regulations were less likely to report cases of lung disease. (cdc.gov)
The U.S. Centers for Disease Control and Prevention reported this week that 530 cases of lung injury have been reported across 38 states and one U.S. territory, and seven deaths have been confirmed in six states. (journalrecord.com)

Management of PAD patients with chronic lung disease requires a multidisciplinary team approach including immunology, pulmonology, infectious disease and physiotherapy. (lww.com)
Research at Barnes-Jewish and Washington University is helping to understand and improve the outcome for patients with chronic lung disease. (barnesjewish.org)

Recent studies suggest that lung specific inflammation is a hallmark of SCA and underlies pulmonary pathology. (clinicaltrials.gov)

Several clinical presentations of the disease have been described. (cdc.gov)
[ 34 ] IPF can be diagnosed clinically based on the typical clinical features and CT scan findings without the need for lung biopsy. (medscape.com)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
Many of the studies published are symptom-based studies (as opposed to objective measures of lung function or clinical examination etc.) and measurement of HAP was not done. (nih.gov)
AIM: To evaluate a range of conventional and novel biomarkers of CF lung disease in a multicentre setting as a contributing study in selecting outcome assays for a clinical trial of CFTR gene therapy. (ox.ac.uk)

Apelin should do the same to help normalize the significant increases in inflammation in the lungs and related breathing difficulties associated with ARDS. (prohealth.com)

Systemic sclerosis is a complex autoimmune disease that has features of a vasculopathy as well as features of fibrosis, or progressive fibrosis, that can affect multiple organs. (ajmc.com)
This ILD disorder is caused by an autoimmune disease and leads to damage of the interstitium. (verywellhealth.com)
No one knows what causes vitiligo, but it may be an autoimmune disease. (nih.gov)

Depending on the stage and severity of disease, resting lung function abnormalities may include reduced lung volumes and diffusion capacity. (cdc.gov)
The severity of the disease was assessed following GINA guidelines. (aerosol-soc.com)

The interstitium supports the alveoli, the tiny balloon-like sacs of the lungs. (verywellhealth.com)
Air flows to and from the alveoli as lungs inflate and deflate during each respiratory cycle. (medscape.com)
The alveoli are where the lungs and the blood exchange oxygen and carbon dioxide during the process of breathing in and breathing out. (kembrel.com)

Pulmonary rehabilitation is a tool that is receiving more acceptance in chronic lung diseases. (who.int)
The key to discovering better treatments for chronic lung diseases sits with the p73 gene, scientists believe. (buzzpost.com)

In 2000, a physician reported that eight former microwave-popcorn factory workers had developed a rare and disabling lung disease, bronchiolitis obliterans. (cdc.gov)

Recent studies suggest that the microbiome may serve as a biomarker for disease, a therapeutic target, or provide an explanation for pathophysiology in lung diseases. (frontiersin.org)

But in a first of its kind study, NIOSH investigators have taken a unique approach by looking at nearly two decades of information about compliance with health and safety regulations leading up to lung disease diagnoses among miners. (cdc.gov)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
As of Dec. 10, the Centers for Disease Control and Prevention reported 2,409 people had been hospitalized for using e-cigarettes or vaping across all 50 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands. (ibtimes.com)
The Centers for Disease Control and Prevention (CDC) has not yet determined the exact cause of the escalating crisis. (qrglaw.com)
Data were found through the Centers for Disease Control and Prevention's Multiple Cause of Death Database, which includes data on all deceased US residents and identifies RA and RA-ILD-related deaths by International Classification of Diseases, Tenth Edition (ICD-10) codes. (rheumatologyadvisor.com)
Smoking is the leading preventable cause of death in the United States, resulting in more than 480,000 deaths - about one in five deaths - each year, according to the U.S. Centers for Disease Control. (uvm.edu)

Information is collected to identify workplaces and industries where exposures may cause lung disease among the employees. (ny.gov)
If an association was observed between the exposures and lung function, most data seemed to demonstrate mild to moderate reductions in lung function, the pathophysiological mechanisms of which need to be investigated. (nih.gov)
The Agency for Toxic Substances and Disease Registry (ATSDR) is mandated by Congress to address potential public health impacts associated with environmental exposures to hazardous substances from waste sites and releases of hazardous substances into the environment. (cdc.gov)

You've got volatile organic compounds, polyethylene glycol, diacetyl, which is known to cause lung disease. (journalrecord.com)

Kevin R. Flaherty, M.D., from the University of Michigan in Ann Arbor, and colleagues conducted a double-blind phase 3 trial in 15 countries involving patients with fibrosing lung disease affecting more than 10 percent of lung volume on high-resolution computed tomography. (healthday.com)

Practical Approach to Lung Health (‎PAL)‎ strategy. (who.int)
We assessed implementation of the Practical Approach to Lung Health [‎PAL]‎ in primary care facilities in the Syrian Arab Republic and its short-term impact on respiratory care in patients aged 5+ years. (who.int)
Title IV of the Coal Mine Health and Safety Act of 1969 authorizes a benefits program, providing medical payments and cash stipends for miners totally disabled because of pneumoconiosis arising out of employment in underground coal mining, as well as for surviving spouses of coal miners whose death resulted from the disease or who were entitled to Black Lung benefits at the time of death. (cdc.gov)
For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. (nationaljewish.org)
Studies describing the impact of the microorganisms found in the respiratory tract on lung health have been published and are discussed here in the context of interstitial lung diseases. (frontiersin.org)
The American Lung Association is working to save lives by improving lung health and preventing lung disease. (kivitv.com)
As per World health Organization, Air Pollution contributed to Stroke, Heart Disease and Lung Disease significantly. (greaterkashmir.com)
Smoking cigarettes will kill you, but before you die, you could experience some pretty terrible diseases and health conditions from smoking. (lung.org)
Title : Work-related lung disease surveillance report, 2007 Corporate Authors(s) : National Institute for Occupational Safety and Health. (cdc.gov)
Using publicly available information contained in MSHA's injury and illness, enforcement, and employment databases, the investigators evaluated the relationship between compliance with federal health and safety regulations and lung disease diagnoses. (cdc.gov)
Want updates on the latest lung health news, including COVID-19, research, inspiring stories and health information? (lung.org)
Join over 700,000 people who receive the latest news about lung health, including COVID-19, research, air quality, inspiring stories and resources. (lung.org)
Join over 500,000 people who receive the latest news about lung health and clean air, research updates, and inspiring stories. (lung.org)
In battling emerging disease, the medical community hopes to use these factors and processes along with an integrated policy under which health care and health programs can address the complexities and ever-changing burden of disease. (yahoo.com)
Helpful In Many Health Issues: Healthy Air Mask of children reduces but not treat the transmission and spread of viruses, germs and other risky airborne inhalants that lead to respiratory diseases and infections. (articlesfactory.com)

All our teams work together with one goal in mind: to provide the best possible evaluation and treatment of your child's lung problems. (cincinnatichildrens.org)

MONDAY, Sept. 30, 2019 (HealthDay News) -- For patients with progressive fibrosing interstitial lung diseases, nintedanib is associated with a lower rate of decline in forced vital capacity (FVC) compared with placebo, according to a study published online Sept. 29 in the New England Journal of Medicine to coincide with the European Respiratory Society International Congress 2019, held from Sept. 28 to Oct. 2 in Madrid. (healthday.com)

Anatomy21

Organisms11

Diseases90

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment63

Psychiatry and Psychology1

Phenomena and Processes32

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Named Groups3

Health Care21

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. (1/5082)

The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease. (2/5082)

C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. (3/5082)

Mechanisms and mediators in coal dust induced toxicity: a review. (4/5082)

Computed radiography dual energy subtraction: performance evaluation when detecting low-contrast lung nodules in an anthropomorphic phantom. (5/5082)

Computerized analysis of abnormal asymmetry in digital chest radiographs: evaluation of potential utility. (6/5082)

Lymphomatoid granulomatosis following autologous stem cell transplantation. (7/5082)

Hexavalent chromium responsible for lung lesions induced by intratracheal instillation of chromium fumes in rats. (8/5082)

Lung Diseases

Lung Diseases, Interstitial

Lung

Lung Diseases, Obstructive

Lung Neoplasms

Pulmonary Fibrosis

Lung Transplantation

Lung Injury

Carcinoma, Non-Small-Cell Lung

Respiratory Function Tests

Cystic Fibrosis

Bronchoalveolar Lavage Fluid

Acute Lung Injury

Farmer's Lung

Pulmonary Disease, Chronic Obstructive

Idiopathic Pulmonary Fibrosis

Lung Volume Measurements

Pulmonary Alveoli

Alveolitis, Extrinsic Allergic

Vital Capacity

Forced Expiratory Volume

Pulmonary Emphysema

Spirometry

Pneumonia

Total Lung Capacity

Bronchopulmonary Dysplasia

Bronchiectasis

Chronic Disease

Tomography, X-Ray Computed

Respiratory Mucosa

Bronchoalveolar Lavage

Smoking

Bronchi

Radiography, Thoracic

Respiratory Distress Syndrome, Newborn

Scleroderma, Systemic

Dermatomyositis

Pulmonary Diffusing Capacity

Pulmonary Surfactant-Associated Protein C

Respiration, Artificial

Infant, Premature, Diseases

Lung Abscess

Lung Diseases, Fungal

Infant, Premature

Macrophages, Alveolar

Asthma

Bronchiolitis Obliterans

Infant, Newborn

Pulmonary Surfactants

Sarcoidosis, Pulmonary

Administration, Inhalation

Bronchoscopy

Dyspnea

Pneumoconiosis

Sarcoidosis

Extravascular Lung Water

Emphysema

Retrospective Studies

Sputum

Bronchitis

Hypertension, Pulmonary

Severity of Illness Index

Silicosis

Mice, Inbred C57BL

Airway Obstruction

Pulmonary Gas Exchange

Small Cell Lung Carcinoma

Polymyositis

Ventilator-Induced Lung Injury

Respiratory Distress Syndrome, Adult

Mucus

Carcinoma, Small Cell

Respiratory Mechanics

Pulmonary Edema

alpha 1-Antitrypsin Deficiency

Oxygen Inhalation Therapy

Pulmonary Circulation

Case-Control Studies

Lymphangioleiomyomatosis

Bleomycin