Pathological processes involving any part of the LUNG.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
Tumors or cancer of the LUNG.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
The transference of either one or both of the lungs from one human or animal to another.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Measurement of volume of air inhaled or exhaled by the lung.
Infection of the lung often accompanied by inflammation.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
Persistent abnormal dilatation of the bronchi.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Inhaling and exhaling the smoke of burning TOBACCO.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
A human infant born before 37 weeks of GESTATION.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
An infant during the first month after birth.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Endoscopic examination, therapy or surgery of the bronchi.
Difficult or labored breathing.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
A pathological accumulation of air in tissues or organs.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
Any hindrance to the passage of air into and out of the lungs.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)
The circulation of the BLOOD through the LUNGS.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A malignant epithelial tumor with a glandular organization.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
Diseases caused by factors involved in one's employment.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An abnormal increase in the amount of oxygen in the tissues and organs.
The excision of lung tissue including partial or total lung lobectomy.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The act of BREATHING out.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Inflammation of the BRONCHIOLES.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Drugs used for their effects on the respiratory system.
Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Inflammation of the lung parenchyma that is caused by bacterial infections.
Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Granulomatous disorders affecting one or more sites in the respiratory tract.
Infections with bacteria of the genus PSEUDOMONAS.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
Substances that reduce or suppress INFLAMMATION.
Any tests done on exhaled air.
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Relatively complete absence of oxygen in one or more tissues.
Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
The rate of airflow measured during a FORCED VITAL CAPACITY determination.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An enzyme that activates histidine with its specific transfer RNA. EC
Measurement of oxygen and carbon dioxide in the blood.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
MYCOBACTERIUM infections of the lung.
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Endoscopic surgery of the pleural cavity performed with visualization via video transmission.
A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.
The structural changes in the number, mass, size and/or composition of the airway tissues.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
So-called atypical species of the genus MYCOBACTERIUM that do not cause tuberculosis. They are also called tuberculoid bacilli, i.e.: M. buruli, M. chelonae, M. duvalii, M. flavescens, M. fortuitum, M. gilvum, M. gordonae, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. kansasii, M. marinum, M. obuense, M. scrofulaceum, M. szulgai, M. terrae, M. ulcerans, M. xenopi.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Inflammation of a muscle or muscle tissue.
A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The airflow rate measured during the first liter expired after the first 200 ml have been exhausted during a FORCED VITAL CAPACITY determination. Common abbreviations are MEFR, FEF 200-1200, and FEF 0.2-1.2.
Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.
A cell line derived from cultured tumor cells.
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Radiography of the bronchial tree after injection of a contrast medium.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.
Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Disease having a short and relatively severe course.

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. (1/5082)

OBJECTIVE: To evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role of the liver in the activation of alveolar macrophages. SUMMARY BACKGROUND DATA: Acute lung injury is the extrapancreatic complication most frequently associated with death and complications in severe AP. Neutrophil infiltration into the lungs seems to be related to the release of systemic and local mediators. The liver and alveolar macrophages are sources of mediators that have been suggested to participate in the lung damage associated with AP. METHODS: Pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. The inflammatory process in the lung and the activation of alveolar macrophages were investigated in animals with and without portocaval shunting 3 hours after AP induction. Alveolar macrophages were obtained by bronchoalveolar lavage. The generation of nitric oxide, leukotriene B4, tumor necrosis factor-alpha, and MIP-2 by alveolar macrophages and the chemotactic activity of supernatants of cultured macrophages were evaluated. RESULTS: Pancreatitis was associated with increased infiltration of neutrophils into the lungs 3 hours after induction. This effect was prevented by the portocaval shunt. Alveolar macrophages obtained after induction of pancreatitis generated increased levels of nitric oxide, tumor necrosis factor-alpha, and MIP-2, but not leukotriene B4. In addition, supernatants of these macrophages exhibited a chemotactic activity for neutrophils when instilled into the lungs of unmanipulated animals. All these effects were abolished when portocaval shunting was carried out before induction of pancreatitis. CONCLUSION: Lung damage induced by experimental AP is associated with alveolar macrophage activation. The liver mediates the alveolar macrophage activation in this experimental model.  (+info)

The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease. (2/5082)

Alpha1 Protease inhibitor (alpha1PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate alpha1PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of patients with cystic fibrosis-associated lung disease who are infected with Pseudomonas aeruginosa. P. aeruginosa secretes pyocyanin, which, through its ability to redox cycle, induces cells to generate reactive oxygen species. We tested the hypothesis that redox cycling of pyocyanin could lead to inactivation of alpha1PI. When alpha1PI was exposed to NADH and pyocyanin, a combination that results in superoxide production, alpha1PI lost its ability to form an inhibitory complex with both porcine pancreatic elastase (PPE) and trypsin. Similarly, addition of pyocyanin to cultures of human airway epithelial cells to which alpha1PI was also added resulted in a loss of the ability of alpha1PI to form a complex with PPE or trypsin. Neither superoxide dismutase, catalase, nor dimethylthiourea nor depletion of the media of O2 to prevent formation of reactive oxygen species blocked pyocyanin-mediated inactivation of alpha1PI. These data raise the possibility that a direct interaction between reduced pyocyanin and alpha1PI is involved in the process. Consistent with this possibility, pretreatment of alpha1PI with the reducing agent beta-mercaptoethanol also inhibited binding of trypsin to alpha1PI. These data suggest that pyocyanin could contribute to lung injury in the P. aeruginosa-infected airway of cystic fibrosis patients by decreasing the ability of alpha1PI to control the local activity of serine proteases.  (+info)

C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. (3/5082)

The anaphylatoxin derived from the fifth component of the human complement system (C5a) mediates its effects by binding to a single high-affinity receptor (C5aR/CD88), the expression of which has been traditionally thought to be restricted to granulocytes, monocytes, macrophages (Mphi), and cell lines of myeloid origin. Recent immunohistochemical data suggested that human bronchial and alveolar cells express C5aR as well. To reexamine the tissue distribution of human C5aR expression, transcription of the C5aR gene was investigated in normal and pathologically affected human lung (bronchopneumonia, tuberculosis), large intestine (acute appendicitis, Crohn's disease), and skin (pyogenic granuloma, lichen planus) using in situ hybridization. In contrast to previous evidence, C5aR mRNA could not be detected in pulmonary or intestinal epithelial cells, whereas keratinocytes in inflamed but not in normal skin revealed detectable levels of C5aR transcripts. Additionally, it could be documented that only migrating Mphi express C5aR mRNA, whereas sessile Mphi in normal tissues and epithelioid/multinucleated Mphi found in granulomatous lesions do not. Because C5a has been demonstrated to upregulate the expression of interleukin (IL)-6 in human monocytes, we also studied IL-6 gene transcription in parallel to the C5aR. IL-6 mRNA was detectable in many tissue Mphi. Surprisingly, a tight co-expression of C5aR and IL-6 mRNA was observed in keratinocytes from lesions of pyogenic granuloma and lichen planus. These results point to an as yet unknown role for C5a in the pathogenesis of skin disorders beyond its well-defined function as a chemoattractant and activator of leukocytes.  (+info)

Mechanisms and mediators in coal dust induced toxicity: a review. (4/5082)

Chronic inhalation of coal dust can cause several lung disorders, including simple coal workers pneumoconiosis (CWP), progressive massive fibrosis (PMF), chronic bronchitis, lung function loss, and emphysema. This review focuses on the cellular actions and interactions of key inflammatory cells and target cells in coal dust toxicity and related lung disorders, i.e. macrophages and neutrophils, epithelial cells, and fibroblasts. Factors released from or affecting these cells are outlined in separate sections, i.e. (1) reactive oxygen species (ROS) and related antioxidant protection mechanisms, and (2) cytokines, growth factors and related proteins. Furthermore, (3) components of the extracellular matrix (ECM), including the modifying role of ROS, cytokines, proteases and antiproteases are discussed in relation to tissue damage and remodelling in the respiratory tract. It is recognised that inhaled coal dust particles are important non-cellular and cellular sources of ROS in the lung, and may be significantly involved in the damage of lung target cells as well as important macromolecules including alpha-1-antitrypsin and DNA. In vitro and in vivo studies with coal dusts showed the up-regulation of important leukocyte recruiting factors, e.g. Leukotriene-B4 (LTB4), Platelet Derived Growth Factor (PDGF), Monocyte Chemotactic Protein-1 (MCP-1), and Tumor Necrosis Factor-alpha (TNF alpha), as well as the neutrophil adhesion factor Intercellular Adhesion Molecule-1 (ICAM-1). Coal dust particles are also known to stimulate the (macrophage) production of various factors with potential capacity to modulate lung cells and/or extracellular matrix, including O2-., H2O2, and NO, fibroblast chemoattractants (e.g. Transforming Growth Factor-beta (TGF beta), PDGF, and fibronectin) and a number of factors that have been shown to stimulate and/or inhibit fibroblast growth or collagen production such as (TNF alpha, TGF beta, PDGF, Insulin Like Growth Factor, and Prostaglandin-E2). Further studies are needed to clarify the in vivo kinetics and relative impact of these factors.  (+info)

Computed radiography dual energy subtraction: performance evaluation when detecting low-contrast lung nodules in an anthropomorphic phantom. (5/5082)

A dedicated chest computed radiography (CR) system has an option of energy subtraction (ES) acquisition. Two imaging plates, rather than one, are separated by a copper filter to give a high-energy and low-energy image. This study compares the diagnostic accuracy of conventional computed radiography to that of ES obtained with two radiographic techniques. One soft tissue only image was obtained at the conventional CR technique (s = 254) and the second was obtained at twice the radiation exposure (s = 131) to reduce noise. An anthropomorphic phantom with superimposed low-contrast lung nodules was imaged 53 times for each radiographic technique. Fifteen images had no nodules; 38 images had a total of 90 nodules placed on the phantom. Three chest radiologists read the three sets of images in a receiver operating characteristic (ROC) study. Significant differences in Az were only found between (1) the higher exposure energy subtracted images and the conventional dose energy subtracted images (P = .095, 90% confidence), and (2) the conventional CR and the energy subtracted image obtained at the same technique (P = .024, 98% confidence). As a result of this study, energy subtracted images cannot be substituted for conventional CR images when detecting low-contrast nodules, even when twice the exposure is used to obtain them.  (+info)

Computerized analysis of abnormal asymmetry in digital chest radiographs: evaluation of potential utility. (6/5082)

The purpose of this study was to develop and test a computerized method for the fully automated analysis of abnormal asymmetry in digital posteroanterior (PA) chest radiographs. An automated lung segmentation method was used to identify the aerated lung regions in 600 chest radiographs. Minimal a priori lung morphology information was required for this gray-level thresholding-based segmentation. Consequently, segmentation was applicable to grossly abnormal cases. The relative areas of segmented right and left lung regions in each image were compared with the corresponding area distributions of normal images to determine the presence of abnormal asymmetry. Computerized diagnoses were compared with image ratings assigned by a radiologist. The ability of the automated method to distinguish normal from asymmetrically abnormal cases was evaluated by using receiver operating characteristic (ROC) analysis, which yielded an area under the ROC curve of 0.84. This automated method demonstrated promising performance in its ability to detect abnormal asymmetry in PA chest images. We believe this method could play a role in a picture archiving and communications (PACS) environment to immediately identify abnormal cases and to function as one component of a multifaceted computer-aided diagnostic scheme.  (+info)

Lymphomatoid granulomatosis following autologous stem cell transplantation. (7/5082)

Lymphomatoid granulomatosis (LYG) is a rare angio-destructive lymphoproliferative disorder (LPD) of uncertain etiology, with prominent pulmonary involvement. Recent studies indicate that LYG is an Epstein-Barr virus (EBV)-associated B cell LPD with large numbers of background reactive T lymphocytes (T cell-rich B cell lymphoma). Although the disease frequently, but not exclusively, occurs in various immunodeficiency states, it has not been reported in association with the transient immunosuppression following autologous bone marrow/peripheral stem cell transplantation (ABM/PSCT). We describe a patient who developed lymphomatoid granulomatosis of the lung approximately 2 weeks after high-dose chemotherapy and autologous peripheral stem cell transplantation for multiple myeloma. Although molecular studies showed no evidence of EBV genome in the biopsy material, the serologic profile with high IgM titers was suggestive of primary EBV infection. Complete radiologic remission occurred following reconstitution of the patient's immune response after a 2-week course of ganciclovir treatment. Despite the apparently low frequency of LPD (both LYG and EBV-associated post-transplant lymphoma) in the ABMT setting, we believe that it should be considered in the differential diagnosis of patients whose clinical course following ABMT is complicated by fevers, in the absence of an identifiable infectious process.  (+info)

Hexavalent chromium responsible for lung lesions induced by intratracheal instillation of chromium fumes in rats. (8/5082)

Lung toxicity of chromium fumes (Cr fumes) was examined by a single intratracheal instillation into rats of 10.6 mg and 21.3 mg Cr fumes/kg body weight and by repeated (3 times) instillations of 10.8 mg and 21.7 mg Cr fumes/kg. The pathological changes were compared with those induced by single administrations of 3.2 mg and 19.2 mg Na2CO3 solution-insoluble fraction of Cr fumes (Cr-Fr)/kg and 20.8 mg commercially available chromium (III) oxide powder (Cr (III) oxide)/kg. Single and repeated administrations of Cr fumes suppressed growth rate in a dose-dependent manner, but administrations of Cr-Fr and Cr (III) oxide did not. A single administration of Cr fumes produced granulomas in the entire airways and alveoli with progressive fibrotic changes, as well as severe mobilization and destruction of macrophages and foamy cells. Those histopathological changes were aggravated by the repeated administration of Cr fumes. On the other hand, single administrations of Cr-Fr and Cr (III) oxide produced no remarkable histopathological changes. Cr fumes were found to be composed of 73.5% chromium (III) oxide and 26.5% chromium (VI) oxide. The primary particles of Cr fumes and Cr-Fr were similar, 0.02 micron in size (sigma g: 1.25), and Cr (III) oxide particles were 0.30 micron in size (sigma g: 1.53), measured by analytical electron microscopy (ATEM). Diffuse clusters of the primary particles in Cr fumes were identified as Cr (VI) oxide. The present results suggested that the lung toxicity of Cr fumes was mainly caused by these Cr (VI) oxide (CrO3) particles in Cr fumes.  (+info)

0000002520 00000 n Restrictive lung diseases are a heterogeneous group of conditions characterized by a restrictive pattern on spirometry and confirmed by a reduction in total lung volume. 0000044299 00000 n xref 0000054386 00000 n 0000027524 00000 n 0000042951 00000 n Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. Ё��X�q��Al�t��L}b#�c8�o���$C ZS{U4O��I�+^/΄,o����i{L�.-_P���=�y>wj�0 U~2;q�j,J�9��y�������02�D��/p,�öH>ి���wU� 0000028555 00000 n 0000028239 00000 n 0000044933 00000 n Restrictive lung disease most often results from a condition causing stiffness in the lungs themselves. interest in evaluating PR for patients with restrictive lung diseases. 0000001036 00000 n Both chronic obstructive pulmonary disease (COPD) and restrictive lung diseases ...
Clipping is a handy way to collect important slides you want to go back to later. Interstitial and Restrictive Disorders 2. Affiliation 1 Department of Internal Medicine, Section of Clinical Immunology and … Factors around the lungs pertain to the chest wall and adjacent spine. (iii) Do obstructive and restrictive l … Do obstructive and restrictive lung diseases share common underlying mechanisms of breathlessness? See our Privacy Policy and User Agreement for details. Within these categories are specific types of chronic lung disease. Obstructive and restrictive lung disease and functional limitation: data from the Third National Health and Nutrition Examination. Restrictive lung diseases may be divided into the following groups:s Intrinsic lung diseases (diseases of the lung parenchyma)s Extrinsic disorders (extra-parenchymal diseases) 4. However, chronic obstructive pulmonary disease (COP… Crossref. 2003 ; 114 (9): 758 - 762. Physiologically restrictive lung diseases are defined by ...
0000028555 00000 n Lung plethysmography estimates the amount of air that is left in the lungs after expiration (functional residual capacity) and can be helpful when there is overlap with other pulmonary function tests.It estimates how much air is left in the lungs (residual capacity), which is a measure of the compliance of the lungs. 80 0 obj stream some conditions that can cause restrictive lung disease include: *interstitial lung disease, such as idiopathic pulmonary fibrosis *sarcoidosis, an autoimmune disease *obesity *scoliosis *neuromu @,���~b 0000029542 00000 n • 2- increased tissue recoil delays airway closure. Exhaling becomes slower and shallower than in a person with a healthy respiratory system.Examples of obstructive lung disease include1: 1. Request PDF , On Jan 1, 2009, Alfredo Chetta and others published Restrictive Lung Disease , Find, read and cite all the research you need on ResearchGate 0000028314 00000 n Extrinsic restrictive lung diseases are considered one of ...
TY - JOUR. T1 - Diffuse lung disease. T2 - Assessment with helical CT - Preliminary observations of the role of maximum and minimum intensity projection images. AU - Bhalla, Meenakshi. AU - Naidich, David P.. AU - McGuinness, Georgeann. AU - Gruden, James F.. AU - Leitman, Barry S.. AU - McCauley, Dorothy I.. PY - 1996/8. Y1 - 1996/8. N2 - PURPOSE: To evaluate assessment of diffuse lung disease with helical computed tomography (CT) and maximum intensity projection (MIP) and minimum intensity projection images. MATERIALS AND METHODS: Six patients with suspected lung disease (the control group) and 20 patients with documented disease underwent axial helical CT through the upper and lower lung fields. Findings on the MIP and minimum intensity projection images of each helical data set were compared with findings on the thin-section scan obtained at the midplane of the series. RESULTS: Owing to markedly improved visualization of peripheral pulmonary vessels (n = 26) and improved spatial orientation, ...
COLD mainly involves two related diseases -- chronic bronchitis and emphysema. Chronic lung disease may be caused by smoking tobacco or by … I was diagnosed with COPD two years ago, and so far I manage to keep on with my life, although I stopped my regular exercise. Lifestyle. Replacement AAT (Prolastin), derived from human blood which has been screened for viruses, is injected weekly or bimonthly for life. With a program of complete respiratory care, disability can be minimized, acute episodes prevented, hospitalizations reduced, and some early deaths avoided. Bronchopulmonary dysplasia is a serious complication of prematurity resulting from poor lung growth and lung injury. Survival of patients with COPD is clearly related to the degree of their lung function when they are diagnosed and the rate at which they lose this function. Bronchopulmonary dysplasia (BPD), also known as neonatal chronic lung disease (CLD), is an important cause of respiratory illness in preterm newborns that results in ...
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric in-hospital surgical procedure under general or regional anaesthesia during a continued 7-day period of recruitment.. Participating centres throughout Europe will contribute routine clinical data describing all eligible patients who undergo surgery during a continuous week (7-days) at convenience of every department within a period of two months from May 1st to July 1st 2011. A questionnaire of around 50 items will be filled during the pre, intra and postoperative periods. The follow-up will end at discharge. The aim of the PERISCOPE study is to validate a simple score to predict postoperative pulmonary complications(PPCs). This score has recently been published in Anesthesiology and you can access linking to: ...
Childrens interstitial and diffuse lung disease (ChILD) is a group of diseases that cause a thickening of the tissue that extends throughout the lungs.
Feeling short of breath all the time could be diffuse lung disease. At MaineHealth, providers coordinate patient care with pulmonologists and other doctors
Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. Unlike obstructive lung diseases, including asthma and COPD, which show a normal or increased total lung capacity (TLC), restrictive disease are ...
As of Monday, more than 100 mysterious cases of severe lung disease across at least 15 states reportedly have been tied to vaping, the act of inhaling and exhaling aerosol (or vapor) produced by devices like e-cigarettes.
TY - JOUR. T1 - Prone or supine for infants with chronic lung disease at neonatal discharge. AU - Elder, D.E.. AU - Campbell, A.J.. AU - Doherty, Dorota. PY - 2005. Y1 - 2005. N2 - To determine whether infants with chronic lung disease (CLD), ready for neonatal unit discharge, maintain cardiorespiratory stability while sleeping supine.Methods: Subjects were 15 infants born. AB - To determine whether infants with chronic lung disease (CLD), ready for neonatal unit discharge, maintain cardiorespiratory stability while sleeping supine.Methods: Subjects were 15 infants born. U2 - 10.1111/j.1440-1754.2005.00584.x. DO - 10.1111/j.1440-1754.2005.00584.x. M3 - Article. C2 - 15813871. VL - 41. SP - 180. EP - 185. JO - Journal of Paediatric and Child Health. JF - Journal of Paediatric and Child Health. SN - 1034-4810. IS - 4. ER - ...
Might a bundled intraoperative protective ventilation strategy help reduce the risk for postoperative pulmonary complications after cardiac surgery?
Acute diffuse lung infiltration in patients with systemic lupus erythematosus (SLE) requires prompt evaluation for diffuse alveolar hemorrhage (DAH) when patients have low levels of hemoglobin and complement compound C4 and symptoms of hypoxia. The development of DAH was significantly associated with the presence of these features, South Korean researchers have found. (Citation Source In their retrospective series of 47 SLE patients with acute diffuse lung infiltration, about half satisfied criteria for DAH, and although mortality was no different between patients with or without DAH (29.2% versus 21.7%), more than 80% of the patients with DAH who died did so within 3 weeks.. Because of this risk of early death, we consider that early detection of diffuse lung infiltration and early suspicion of DAH will be key factors in improving the prognosis of DAH in SLE patients, wrote Dam Kim, MD, PhD, from Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ...
Due to the special growth and developmental characteristics of newborn infants, VILI is thought to play an important role in the pathogenesis of neonatal chronic lung disease, which has an adverse effect on the survival rate and the quality of life for newborns with ALI/ARDS. To study newborn ALI/ARDS, newborn animals, such as piglets,5,6 rats,7 and rabbits,8 have been used as animal models. Because the organ development, lung volume, and birth weight of newborn piglets resemble those of newborn infants, the current study used induced ALI/ARDS in newborn piglets.. One of the aims in this study was to compare the histopathological features of the lung damage in gravitation-dependent and gravitation-nondependent regions. Compared to the gravitation-nondependent region, the gravitation-dependent region displayed increased lung swelling and hemorrhaging, and damage to the alveolar integrity and organization. We observed increased inflammatory cell infiltration, edema formation, and hemorrhages, ...
MedHelps Chronic Obstructive Pulmonary Disorder Help Forum. This forum is for help, questions and support regarding Chronic Obstructive Pulmonary Disorder
THURSDAY, Feb. 20, 2020 (HealthDay News) -- Lung diseases have been striking more people around the world in the past 30 years, new research shows.. And being from poor regions is the most important risk factor for respiratory trouble, the scientists added.. Aging and risk factors such as smoking, pollution and overweight/obesity are among the other major risk factors for chronic lung diseases, according to the analysis of data from 195 countries.. Researchers led by Dr. Min Xie, from Tongji Medical College and Huazhong University of Science and Technology in Wuhan, China, found that the number of deaths from chronic lung diseases rose 18% over the past three decades, from 3.3 million in 1990 to 3.9 million in 2017.. The number of deaths increased with age and rose sharply among people aged 70 and older, and this age-related burden is likely to increase as the worldwide population ages, the researchers noted.. The most common chronic lung diseases are chronic obstructive pulmonary disease (COPD) ...
POCUS had a sensitivity of 89%, specificity of 59% and a NPV of 93% compared with PCR or CT scanning in diagnosing pulmonary manifestations of COVID-19. Moreover, in patients without cardiopulmonary disease, POCUS had a 100% sensitivity and a 100% NPV for pulmonary involvement of COVID-19. This indicates that pulmonary manifestations of COVID-19 may be excluded by POCUS in patients without previous cardiac or pulmonary medical history; in whom normally no pulmonary abnormalities are expected. This was underlined by a negative likelihood ratio of 0.19 and 0 in a general population and in a population without cardiopulmonary history, respectively. These numbers contribute to a useful change in post-test probability, as opposed to the less contributing positive likelihood ratio (2.17 and 4.17, respectively).. The difference in sensitivity and specificity between patients with and without cardiopulmonary disease may very well be related to the non-specific lung findings of COVID-19 observed with ...
Dr. Alap Shah Covid-19 results into Restrictive Lung disease. It becomes difficult for Air to reach upto all parts of Lungs, reducing oxygen level in body. With
This is the first longitudinal assessment of CT-detected structural lung disease in young children with CF detected by newborn screening. The observations provide a unique insight to the early development of CF lung disease and factors associated with the persistence and progression of structural changes. We found that neutrophilic inflammation and pulmonary infection were independently associated with progression of bronchiectasis, with neutrophilic inflammation associated with progression of air trapping. Importantly, neutrophilic inflammation at the initial scan was associated with subsequent progression of structural lung disease and might therefore be an early predictor of significant future lung disease. These findings are in agreement with earlier cross-sectional studies that implicated neutrophilic inflammation and pulmonary infection as risk factors for structural lung disease.4 5 We also identified an association between air trapping at the initial scan and subsequent persistence and ...
Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get them in front of Issuus millions of monthly readers. Title: Chronic Lung Disease (New edition of To Air is Human), Author: Pritchett & Hull Associates, Inc., Name: Chronic Lung Disease (New edition of To Air is Human), Length: 84 pages, Page: 1, Published: 2013-10-18
A loving relationship with your partner can help you deal with your chronic lung disease and the emotions that come with it. Yet a person with a chronic lung disease may have problems that interfere with being close.
A loving relationship with your partner can help you deal with your chronic lung disease and the emotions that come with it. Yet a person with a chronic lung disease may have problems that interfere with being close.
Fishpond Australia, Chronic Lung Disease in Early Infancy by Richard D Bland (Edited ) Jacqueline J Coalson (Edited )Buy . Books online: Chronic Lung Disease in Early Infancy, 1999,
Being close to someone with chronic lung disease will likely mean some changes in your life. As your loved one copes with chronic lung disease, you may be asked to be a helper, caregiver, or source of support.
MONDAY, Dec. 16, 2019 (HealthDay News) -- As if the news on vaping wasnt bad enough, a new study suggests that e-cigarette users are also at significantly higher risk of chronic lung diseases such as asthma, bronchitis, emphysema and COPD.. Those risks rose even higher if vapers also smoked tobacco, researchers said.. What we found is that for e-cigarette users, the odds of developing lung disease increased by about a third, even after controlling for their tobacco use and their clinical and demographic information, said study senior author Stanton Glantz. He directs the Center for Tobacco Control Research and Education at the University of California, San Francisco.. In the new study, Glantzs team tracked data on the cigarette and e-cigarette use of more than 32,000 U.S. adults, none of whom had lung disease at the start of the study.. The researchers then recorded new lung disease diagnoses over the years 2013 to 2016. Those diagnoses included such common and debilitating illnesses as ...
These changes have prompted action at the federal level, leading to the creation of the new Congressional Caucus to End the Youth Vaping Epidemic. This caucus is being led by U.S. Representative Raja Krishnamoorthi, a Democrat who is co-leading with the Republican Representative Peter King and Democratic Senator Dick Durbin. They believe that the vape flavors, which were often sweet, are what drew children into vape usage. While JUUL insists that they never marketed to children, they have since removed many flavors from retail shelves. Currently, the primary remaining flavors are ethanol and mint, which are still popular flavors. For far too long, e-cigarette manufacturers have illegally advertised their products and profited on the backs of American youth, Representative Krishnamoorthi said. I am honored to launch the premier forum in Congress for like-minded members, on both sides of the aisle, to work together to combat the growing youth e-cigarette epidemic and to protect children and ...
Description of disease Lung disease - resources. Treatment Lung disease - resources. Symptoms and causes Lung disease - resources Prophylaxis Lung disease - resources
Health officials in several states are exploring a possible link between adolescent vaping and severe lung cancer. Texas became the latest state to investigate, announcing its plans Monday. Doctors are being asked to carefully document any lung cancer cases they believe may be linked to vaping, including obtaining a sample of the vaping liquid used by each patient. The Centers for Disease Control reports 94 cases of lung cancer it believes are linked to vaping. The cases are spread across 14
Health officials in several states are exploring a possible link between adolescent vaping and severe lung cancer. Texas became the latest state to investigate, announcing its plans Monday. Doctors are being asked to carefully document any lung cancer cases they believe may be linked to vaping, including obtaining a sample of the vaping liquid used by each patient. The Centers for Disease Control reports 94 cases of lung cancer it believes are linked to vaping. The cases are spread across 14
The phagocytic system is an indispensable part of the immune defense mechanism and innate immune system. Pulmonary manifestations could be either ambiguous or misleading. The most common involved...
Lung disease is the major cause of death and hospitalization worldwide. Transcription factors such as transcription factor 7 (TCF7) are involved in the pathogenesis of lung diseases. TCF7 is important for T cell development and differentiation, embryonic development, or tumorogenesis. Multiple TCF7 isoforms can be characterized by the full-length isoform (FL-TCF7) as a transcription activator, or dominant negative isoform (dn-TCF7) as a transcription repressor. TCF7 interacts with multiple proteins or target genes and participates in several signal pathways critical for lung diseases. TCF7 is involved in pulmonary infection, allergy or asthma through promoting T cells differentiating to Th2 or memory T cells. TCF7 also works in tissue repair and remodeling after acute lung injury. The dual roles of TCF7 in lung cancers were discussed and it is associated with the cellular proliferation, invasion or metastasis. Thus, TCF7 plays critical roles in lung diseases and should be considered as a new
Work-related lung diseases are lung problems that are made worse in certain work environments. They are caused by long-term exposure to certain irritants that are breathed into the lungs. These lung diseases may have lasting effects, even after the exposure ends.
Work-related lung diseases are lung problems that are made worse in certain work environments. They are caused by long-term exposure to certain irritants that are breathed into the lungs. These lung diseases may have lasting effects, even after the exposure ends.
At MedStar Washington, we provide comprehensive diagnosis and treatment for cardiopulmonary disease. Learn more about our services today.
FRIDAY, Sept. 4, 2020 (HealthDay News) -- Even light smokers are much more likely to die of lung disease or lung cancer than nonsmokers, a new study warns.. Everyone knows that smoking is bad for you, but its easy to assume that if you only smoke a little, the risks wont be too high, said study co-leader Pallavi Balte, of Columbia University Irving Medical Center, in New York City. The new study shows how wrong that thinking can be. It included nearly 19,000 people in the United States, average age 61, who were followed for an average of 17 years. During that time, nearly 650 died of lung disease (such as emphysema) and 560 died of lung cancer.. Among nonsmokers, less than 2% died from lung disease and less than 1% died from lung cancer. But among social smokers (fewer than 10 cigarettes a day), those numbers were over 3% and close to 5%, respectively.. Not surprisingly, heavy smokers (more than 20 cigarettes a day) fared worst, with more than 10% dying from lung disease and about 13% from ...
In preparation for the NCLEX-RN exam, this chapter covers common noninfectious disorders that contribute to chronic lung disease, occupational lung disorders, infectious diseases of the lower respiratory tract, acute respiratory disorders that threaten the clients life, and emerging pulmonary infections.
As mentioned above, obstructive lung disease is characterized by breath shortness. This is usually brought about by the difficulty that one experiences in exhaling all the air present in the lungs. As a result, the lungs are damaged in some way and that is why the exhaled air takes too long to be exhaled. Even after a successful completion of the exhalation process, chances are there is a significant amount of air left in your lungs.. ...
Juan J Russo, Pablo B Nery, Andrew C Ha, Jeff S Healey, Daniel Juneau, Lena Rivard, Matthias G Friedrich, Lorne Gula, Gerald Wisenberg, Robert deKemp, Santabhanu Chakrabarti, Tomasz W Hruczkowski, Russell Quinn, F. Daniel Ramirez, Girish Dwivedi, Rob SB Beanlands, David H Birnie ...
Arik Bernard Schulze, Georg Evers, Andreas Kümmel, Felix Rosenow, Jan Sackarnd, Jan Philipp Hering, Christoph Schülke, Jonas Andreas Engelbertz, Dennis Görlich, Peter J Barth, Georg Lenz, Heidemarie Becker, Michael Mohr, Lars Henning Schmidt ...
Learn about the causes, symptoms, diagnosis & treatment of Symptoms of Pulmonary Disorders from the Professional Version of the Merck Manuals.
Get this from a library! Pulmonary disorders of the elderly : diagnosis, prevention, and treatment. [Thomas L Petty; James S Seebass; American College of Physicians (2003- );]
Study Flashcards On PULMONARY DISORDERS at Quickly memorize the terms, phrases and much more. makes it easy to get the grade you want!
Age related chronic pulmonary diseases and cancer share immune, inflammatory, and metabolic abnormalities associated with conditions inducing cellular senescence, including oxidative stress, genomic instability, DNA damage, dysfunction of mitochondria and telomeres.. Novel exciting perspectives have been provided in lung biology by recent breakthroughs: the complex interplays between intrinsic or alien cellular components can influence strongly the normal function of lung tissue.. The reinforcement of on-going programs on inflammatory, fibro-proliferative, cancerous and genetic lung diseases, combined with development of novel technologies in cell biology (3D cultures, stem cells, genome editing, metagenomics, genetics, functional genomics, and pharmacology) will open major breakthroughs in lung diseases. Many unknowns remain in the description and understanding of the mechanisms at work during normal tissue differentiation, or in adverse situation experienced during ageing or cancer. A major ...
Oh and looks like they wont let you even visit their site unless your 21, so no one younger should get this stuff. Read who was effected. They were not effected by that very old company. I am not shilling for blu e-cigs, I used them way back in the day, quit smoking completely, and never looked back. I did use their product for a couple years and never had the issues described. I even had asthma as a child but outgrew it. I never liked how cigarettes made me feel (it was stupid trend) and I never had the same minor lung issues with blu cigs as tobacco. Between the two (if you had to make a choice) ecigs was the lesser of the two evils. I also waited a year before jumping in and only got speculation of deadly side effect reports ...
June 6th, 2020. We describe an ex-premature infant presenting with SARS-CoV-2 infection in the 5th week of life. Current reports indicate that acute symptomatic SARS-CoV-2 infection is relatively rare and much less severe than in adults. This case highlights that infection can be associated with life threatening pulmonary disease in young infants and that infection can follow a similar disease course to that described in adults. We provide first data on the use of the novel antiviral remdesivir in a young child and an innovative approach to expedited approval from a multidisciplinary clinical team and bioethics committee for compassionate access to the drug.. Read the full article here.. ...
TY - JOUR. T1 - The Intersection of Aging Biology and the Pathobiology of Lung Diseases. T2 - A Joint NHLBI/NIA Workshop. AU - Budinger, Gr Scott. AU - Kohanski, Ronald A.. AU - Gan, Weiniu. AU - Kobor, Michael S.. AU - Amaral, Luis A.. AU - Armanios, Mary. AU - Kelsey, Karl T.. AU - Pardo, Annie. AU - Tuder, Rubin. AU - Macian, Fernando. AU - Chandel, Navdeep. AU - Vaughan, Douglas. AU - Rojas, Mauricio. AU - Mora, Ana L.. AU - Kovacs, Elizabeth. AU - Duncan, Steven R.. AU - Finkel, Toren. AU - Choi, Augustine. AU - Eickelberg, Oliver. AU - Chen, Danica. AU - Agusti, Alvar. AU - Selman, Moises. AU - Balch, William E.. AU - Busse, Paula. AU - Lin, Anning. AU - Morimoto, Richard. AU - Sznajder, Jacob I.. AU - Thannickal, Victor J.. PY - 2017/11/1. Y1 - 2017/11/1. N2 - Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately ...
If you have asthma, COPD, cystic fibrosis, or chronic bronchitis, youre not alone. Chronic lung disease is becoming a huge problem in this country. And you dont have to smoke to be at risk. Fortunately, supplements can help considerably with lung problems. And new research suggests one nutrient in particular can help.
Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,. VI. Malignant tumors A. Lung cancers Lung is a vital organ of the human being, located near the …. ...
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
Coping with the physical limitations of chronic lung disease can be a challenge for both your loved one and you. But you can each take steps to simplify your daily routine.
stomach and lung diseases. against freckles Latvia. "revitalization". washing hair Poland. "revitalization", kidney stones. ... prevention of) eye diseases, skin diseases, source for vitamins. washing hair, against freckles and to bleach the skin ... treating skin diseases, source of vitamins, diuretic. against freckles United Kingdom. tonic, rheumatism, first nourishment for ...
Norbert F. Voelkel; William MacNee (2002). Chronic Obstructive Lung Diseases. PMPH-USA. p. 380. ISBN 978-1-55009-133-5. ...
"Diseases and conditions index - hypotension". National Heart Lung and Blood Institute. September 2008. Retrieved 2008-09-16.. ... What Is Pulmonary Hypertension? From Diseases and Conditions Index (DCI). National Heart, Lung, and Blood Institute. Last ... It can be useful in the differentiation of different forms of heart and lung disease. ... Long-term hypertension is a risk factor for many diseases, including heart disease, stroke and kidney failure. Long-term ...
Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ... Diseases that cause lower airway obstruction are termed obstructive lung diseases. Lower airway obstruction can be measured ... Further information: Obstructive lung disease. Lower airway obstruction is mainly caused by increased resistance in the ...
ISBN 978-0-8247-1992-0. Marvin I. Schwarz; Talmadge E. King (2010). Interstitial Lung Disease. PMPH-USA. p. 538. ISBN 978-1- ... On the Incidence of Rheumatic Diseases 1931 Sheldon Francis Dudley, On Lessons on Infectious Diseases in The Royal Navy 1932 ... Drug Abuse as a Communicable Disease 1972 A. Gerald Shaper, Cardiovascular Disease in the Tropics 1973 D.J. Bauer, Antiviral ... ISBN 978-1-317-31866-8. William Heaton Hamer (1906). The Milroy Lectures on Epidemic Disease in England: The Evidence of ...
Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... Acute lung injury may also cause pulmonary edema through injury to the vasculature and parenchyma of the lung. Acute lung ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ... What Is Pulmonary Hypertension? From Diseases and Conditions Index (DCI). National Heart, Lung, and Blood Institute. Last ...
If heart disease and lung disease have been excluded, a ventilation/perfusion scan is performed to rule out CTEPH. If unmatched ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... Hematologic diseases: chronic hemolytic anemia (including sickle cell disease). *Systemic diseases: sarcoidosis, pulmonary ... Metabolic disorders: glycogen storage disease, Gaucher disease, thyroid diseases. *Others: pulmonary tumoral thrombotic ...
"Divergent Roles for TRAIL in Lung Diseases". Frontiers in Medicine. 5: 212. doi:10.3389/fmed.2018.00212. PMC 6072839. PMID ... TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary ...
... lung disease, e.g. an infection of the lungs not related to the medicinal drugs the patient is taking. But if the patient is ... Pulmonary = lung. Pulmonary toxicity = pulmonary injury = lung injury = lung toxicity. And instead of pulmonary toxicity (a ... even including lung cancer in some cases, mainly in cases of asbestos-related lung disease, but today this is very rare, ... Asbestos-related lung disease. Am Fam Physician. 2007 Mar 1;75(5):683-8. Review.Fulltext Miller KA, Siscovick DS, Sheppard L, ...
Saiman L (2004). "Microbiology of early CF lung disease". Paediatric Respiratory Reviews. 5 Suppl A: S367-69. doi:10.1016/S1526 ... Tubercle and Lung Disease. 79 (3): 153-69. doi:10.1054/tuld.1998.0200. PMID 10656114.. ... as was the case with Helicobacter pylori and peptic ulcer disease. Bacterial diseases are also important in agriculture, with ... "Emerging Infectious Diseases. 8 (9): 881-90. doi:10.3201/eid0809.020063. PMC 2732559. PMID 12194761.. ...
Imaging of Interstitial Lung Disease. Clinics Chest Med, 2004;25:455-465. Craighead JE et al. Diseases Associated with Exposure ... The disease arises firstly through the deposition of silica or coal dust (or other dust) within the lung, and then through the ... The most notable indications are the fact that the disease tends to develop in the upper lobe of the lung - especially on the ... Immunologically, disease is caused primarily through the activity of lung macrophages, which phagocytose dust particles after ...
"Diacetyl-induced lung disease". Toxicol Rev. 25 (4): 261-272. doi:10.2165/00139709-200625040-00006. PMID 17288497. Food portal ... a rare and life-threatening form of non-reversible obstructive lung disease in which the bronchioles (small airway branches) ...
Esther CR, Jr; Alexis, NE; Picher, M (2011). "Regulation of airway nucleotides in chronic lung diseases". Sub-cellular ... In Alzheimer's disease (AD), the expression of A1 and A2A receptors in the frontal cortex of the human brain is increased, ... The expression of the adenosine A2A receptor on endothelial cells is upregulated in the early stages of human lung cancer. ... Following tissue injury in patients with Graft-versus-host disease (GVHD), ATP is released into the pertioneal fluid. It binds ...
... congenital diffuse lung disease characterized by abnormal blood vessels in the lungs that cause highly elevated pulmonary blood ... Bilateral lung transplantation may be the definitive treatment. Epidemiology[edit]. ACD is a rare disease. As of 2011, about ... ACD is typically diagnosed by examination of lung tissue under a microscope, either from lung biopsy or an autopsy. The ... "Interstitial lung disease in newborns". Seminars in Fetal and Neonatal Medicine. 22 (4): 227-233. doi:10.1016/j.siny.2017.03. ...
"What Is Sickle Cell Disease?". National Heart, Lung, and Blood Institute. June 12, 2015. Archived from the original on March 6 ... Sickle cell disease[edit]. He is best known for his discovery of a treatment for sickle cell disease, a hereditary blood ... He led the research team that discovered the first effective treatment for sickle cell disease, a painful and sometimes fatal ... Patricia 'Pat' Charache, 85, Hopkins infectious diseases specialist, medical microbiologist and educator, dies". Baltimore Sun ...
ISBN 978-0-8385-6687-9. Wells, RG (2015). "Neonatal Lung Disease". Diagnostic Imaging of Infants and Children. McGraw Hill. ... The increased fluid in the lungs leads to increased airway resistance and reduced lung compliance. It is thought this could be ... fluid infiltrate throughout alveoli or fluid in individual lung lobes. The lungs may also appear hyperinflated. Supportive care ... It is caused by retained fetal lung fluid due to impaired clearance mechanisms. It is the most common cause of respiratory ...
A new occupational problem called indium lung disease was developed through contact with indium-containing dusts. The first ... "Indium Lung Disease". Chest. 141 (6): 1512-1521. doi:10.1378/chest.11-1880. PMC 3367484. PMID 22207675. Brock, Kristie; ... Studies with animals indicate that indium tin oxide is toxic when ingested, along with negative effects on the kidney, lung, ... patient is a worker associated with wet surface grinding of ITO who suffered from interstitial pneumonia: his lung was filled ...
Lloyd, Stacey (2006-11-08). "Why Cold Air Causes Breathing Difficulty in Lung Disease Patients". About: Lung Diseases. Archived ... The Centers for Disease Control and Prevention estimate that 1 in 11 children and 1 in 12 adults have asthma in the United ... In both people with asthma and people who are free of the disease, inhaled allergens that find their way to the inner airways ... Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed. John M. Miller, Douglas P. Zipes. "CHAPTER 33 - ...
ISBN 978-3-540-77982-7. C.A.C. Pickering; L. Doyle; K.B. Carroll (1981). "4. Honeycomb lung". Interstitial Lung Disease. MTP ... signs in the mouth and the appearance of advanced gum disease. Features relating to lung and liver disease may occur. It is due ... There may be large lymph nodes and signs of lung and liver disease. Affected people may present with fever and weight loss. The ... The disease was once thought to be a lipid storage disease as the lesions have a high cholesterol content, but the blood ...
Juan Silveti Reynoso (88), bullfighter; lung disease (b. October 5, 1929). December 25 Rudy Casanova (50), Cuban-born Mexican ... Analy Loera, businesswoman and cultural promoter; brain and lung cancer. January 3 Cecilia González Gómez, 55, politician, ... January 27 Fredman Cruz Maldonado, singer; lung problems. Mario Palestina Moreno (45), baseball player; heart attack (b. 1971 ... Jaime Avilés Iturbe (63), journalist (Unomásuno) and columnist (La Jornada and Proceso); lung cancer. Rius, 83, political ...
"Positive Preclinical Results for Lung Cancer Drug Announced at Annual Meeting of Cancer Research - Lung Disease News". Lung ... a drug for the treatment of autoimmune diseases such as Crohn's disease, ulcerative colitis and rheumatoid arthritis, ReoPro® ( ... While Berger was CEO, ARIAD developed five new medicines including the blood-cancer drug Iclusig, Brigatinib, a lung cancer ... "Comparison of exercise radionuclide angiocardiography and thallium-201 myocardial perfusion imaging in coronary artery disease ...
IPF is a progressive fibrotic disease where the lining of the lungs become thickened and scarred. Increased ROCK activity has ... Semedo D (June 5, 2016). "Phase 2 Study of Molecule Inhibitor for Idiopathic Pulmonary Fibrosis Begins". Lung Disease News. ... Treatment with belumosudil reduced lung fibrosis in a bleomycin mouse model study. Belumosudil may have a therapeutic benefit ... is an experimental drug being explored for the treatment of chronic graft versus host disease (cGvHD), idiopathic pulmonary ...
Inflammatory lung diseases are characterized by expression of specific inflammatory genes such as NF-κB and AP-1 transcription ... Human diseases[edit]. Inflammatory diseases[edit]. Gene expression is regulated by histone acetylation and deacetylation, and ... Treatments with corticosteroids and theophylline for inflammatory lung diseases interfere with HAT/HDAC activity to turn off ... importance in inflammatory lung diseases". The European Respiratory Journal. 25 (3): 552-63. doi:10.1183/09031936.05.00117504. ...
Figure B shows lungs with asbestos-related diseases, including pleural plaque, lung cancer, asbestosis, plaque on the diaphragm ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ... Lung cancer, mesothelioma, pleural fibrosis, pulmonary heart disease[1][2]. Usual onset. ~10-40 years after long-term exposure[ ...
Many particles in disease fuel are so tiny they are able to penetrate deep into the lungs when inhaled. Importantly, diesel ... Types of disease interaction[edit]. Diseases regularly interact and this interaction influences disease course, expression, ... Influenza virus alters the lungs in ways that increase the adherence, invasion and induction of disease by pneumococcus, alters ... One disease can assist the physical transmission of the microbe causing another disease, for example, genital-tract ulceration ...
Obstructive lung diseaseEdit. Acetylcysteine is used in the treatment of obstructive lung disease as an adjuvant treatment.[28] ... Stockley RA (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management. Chichester: John Wiley & Sons. p. ... Large doses in a mouse model showed that acetylcysteine could potentially cause damage to the heart and lungs.[45] They found ... Kidney diseaseEdit. Some reviews found that prior administration of acetylcysteine decreases radiocontrast induced kidney ...
Lung diseaseEdit. Active alveolitis is often treated with pulses of cyclophosphamide, often together with a small dose of ... June 2006). "Cyclophosphamide versus placebo in scleroderma lung disease". N. Engl. J. Med. 354 (25): 2655-66. doi:10.1056/ ... Lungs. Some impairment in lung function is almost universally seen in patients with diffuse scleroderma on pulmonary function ... Therefore, HSCT should be given early in the progression of the disease, before it does damage. Patients with heart disease, ...
Belhocine, M.; Ait-Khaled, N. (1991). "Europe PMC". Bulletin of the International Union Against Tuberculosis and Lung Disease. ... Evaluation d'une intervention de sante au niveau d'un secteur sanitaire d'Algerie". Tubercle and Lung Disease. Supplement 2 (76 ... Bulletin of the International Union Against Tuberculosis and Lung Disease. 66 (2-3): 91-93. ISSN 1011-789X. PMID 1756298. " ... The International Journal of Tuberculosis and Lung Disease. 8 (7): 873-881. PMID 15260280. "Let's Move For Our Health". ...
... interstitial lung disease Rare (. ...
Tubercle and Lung Disease. 79 (3): 153-69. doi:10.1054/tuld.1998.0200. PMID 10656114. Lindberg AA (November 1999). "Polyosides ... It is a well-organized layer, not easily washed off, and it can be the cause of various diseases. The capsule-which can be ... The capsule is considered a virulence factor because it enhances the ability of bacteria to cause disease (e.g. prevents ... Hathaway LJ, Grandgirard D, Valente LG, Täuber MG, Leib SL (March 2016). "Streptococcus pneumoniae capsule determines disease ...
They can cause lung cancer, heart disease and many other diseases. Most packs of cigarettes have warning labels on them. ... Tar is a sticky substance that kills cells and causes lung cancer. ...
Diseases and symptoms[edit]. Pneumonia is the most common of the S. pneumoniae diseases which include symptoms such as fever ... After S. pneumoniae colonizes the air sacs of the lungs, the body responds by stimulating the inflammatory response, causing ... 16: Pneumococcal Disease". In Atkinson W; Wolfe S; Hamborsky J. Epidemiology and Prevention of Vaccine-Preventable Diseases ( ... "Centers for Disease Control and Prevention.. *^ "Pneumococcal vaccines WHO position paper--2012" (PDF). Wkly Epidemiol Rec. 87 ...
Infectious diseasesEdit. Imaging infections with molecular imaging technologies can improve diagnosis and treatment follow-up. ... PET in the management of patients with non-small-cell lung cancer (NSCLC). Journal of Experimental & Clinical Cancer Research ... Cardiology, atherosclerosis and vascular disease study: In clinical cardiology, FDG-PET can identify so-called "hibernating ... March 1999). "In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease". Neurology. 52 (4): ...
"Ebola Virus Disease". SRHD. Retrieved 15 September 2020.. *^ a b c d "Q&A on Transmission, Ebola". Centers for Disease Control ... but not very much in their lungs.[77] It is believed that this is the reason researchers have observed pig to primate ... "About Ebola Virus Disease". Centers for Disease Control and Prevention (CDC). Archived from the original on 16 October 2014. ... "Ebola (Ebola Virus Disease) Transmission". Centers for Disease Control and Prevention (CDC). 5 November 2014. Archived from the ...
Some terrestrial species lack both lungs and gills and perform gas exchange through their skin. Even some species with lungs ... The disease is spreading into eastern Panama and threatening all amphibians living there.[27] ... Because of this they have shorter lungs. Short lungs helps them to float easily. ... Species that lack lungs respire through gills. In most cases, these are external gills, visible as tufts on either side of the ...
... coronary heart disease, and cerebrovascular disease, because they ate mostly lean meats and plants and frequently engaged in ... finished off by a blast in the lungs, and ritualistically worshipped near a clay bear statue covered by a bear fur with the ... caused by other factors such as disease and overhunting by humans.[16][17] New research suggests that the extinction of the ... It is also unlikely that Paleolithic hunter-gatherers were affected by modern diseases of affluence such as type 2 diabetes, ...
Lung SC, Chuong SD (April 2012). "A transit peptide-like sorting signal at the C terminus directs the Bienertia sinuspersici ... Many became exaptations, taking on new functions like participating in cell division, protein routing, and even disease ...
It is often described as being "a disease of the diseased", occurring in the very young, the very old, or the very sick. ... It is possible for candidiasis to spread to/from the mouth, from sites such as the pharynx, esophagus, lungs, liver, anogenital ... Candidiasis can be a marker for underlying disease, so the overall prognosis may also be dependent upon this. For example, a ... 2006). Andrews' Diseases of the Skin: Clinical Dermatology. Philadelphia: Saunders Elsevier. p. 308. ISBN 0-7216-2921-0. OCLC ...
SP concentrations cannot yet be used to diagnose disease clinically or gauge disease severity. It is not yet known whether ... a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells". Cancer ... Microbial Toxins and Diarrhoeal Disease. Ciba Found. Symp. 112. pp. 139-54. doi:10.1002/9780470720936.ch8. PMID 2861068.. ... Quantification in diseaseEdit. Elevation of serum, plasma, or tissue SP and/or its receptor (NK1R) has been associated with ...
Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... Veno-occlusive disease[edit]. Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of ... Major complications are veno-occlusive disease, mucositis, infections (sepsis), graft-versus-host disease and the development ... Autoimmune diseases[9]. Many recipients of HSCTs are multiple myeloma[10] or leukemia patients[11] who would not benefit from ...
listen)) is the science and practice of the diagnosis, treatment, and prevention of disease.[4][5] The word "medicine" is ... lungs, digestive tract, urinary tract, etc.). ... Pathology as a science is the study of disease-the causes, ... Preventive medicine is the branch of medicine concerned with preventing disease. *Community health or public health is an ... Pathology as a medical specialty is the branch of medicine that deals with the study of diseases and the morphologic, ...
By 1682, when William Penn arrived to his American commonwealth, the Lenape had been so reduced by disease, famine, and war ... Little Turtle, We-lung-ung-sil. *Snapping Turtle, Lee-kwin-a-i' ... as the diseases had arisen on the Asian continent and moved ... due to high fatalities from epidemics of infectious diseases carried by Europeans, such as measles and smallpox, to which they ... Lenape communities were weakened by newly introduced diseases originating in Europe, mainly smallpox but also cholera, ...
... cardiovascular disease, and lung ailments such as emphysema, bronchitis, and asthma.[7] Specifically, meta-analyses show that ... heart disease and other smoking related diseases") See also WHO Framework Convention on Tobacco Control; First international ... which include an increased risk of heart disease, cancer, emphysema, and other diseases. Laws implementing bans on indoor ... Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease ...
David Heart and Lung Research Institute, Electroscience Laboratory, Large Binocular Telescope (LBT, originally named the ... a research institute for cardiovascular disease. ...
Manuel Bandeira, Brazilian poet, had TB in 1904 and expressed the effects of the disease in his life in many of his poems. ... Peter Purves Smith (1912-1949), Australian modernist artist, died during a lung operation ... He was rumored to have discovered his disease when he coughed blood and fainted during the Ikedaya Affair. ... Dick Martin, comedian; lost a lung due to tuberculosis as a teenager ...
Interstitial lung disease. Mechanism of action[edit]. Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that ... February 2015). "Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and ... It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ... In March 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug.[13] Fall 2010 interim results ...
... and Prevention of Chronic Obstructive Pulmonary Disease. Global Initiative for Chronic Obstructive Lung Disease. halaman 1-7.. ... Global Initiative for Chronic Obstructive Lung Disease. halaman 9-17.. *^ Reilly JJ, Silverman EK, Shapiro SD (2011). "Chronic ... Global Initiative for Chronic Obstructive Lung Disease (GOLD). halaman 6-17.. .mw-parser-output cite.citation{font-style: ... Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary". Respirology. 22 (3): 575- ...
... subluxation is the sole cause of disease and manipulation is the cure for all diseases of the human race.[4][41] A 2003 ... the lungs, or the stomach) that subluxation significantly contributes to, the mean response was 62%.[37] A 2008 survey of 6,000 ... Palmer, a magnetic healer, hypothesized that manual manipulation of the spine could cure disease.[214] The first chiropractic ... A subluxated vertebra ... is the cause of 95 percent of all diseases ... The other five percent is caused by displaced joints ...
Significant diseases. Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ... such as lungs) especially lend themselves to projection radiography. It is a relatively low-cost investigation with a high ...
Air enters, inflating the lung through either the nose or the mouth into the pharynx (throat) and trachea before entering the ... As such, it happens automatically (though there are exceptions in some disease states) and does not need conscious control or ... Breathing allows oxygen (which humans and a lot of other species need for survival) to enter the lungs, from where it can be ... This results in an increased radiolucency on X-ray, a reduction in lung markings and depression of the diaphragm. It may occur ...
Shortly afterwards, Loring Chase came to Orange County from Chicago to recuperate from a lung disease. In his travels, he ...
Intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of ... This includes medical ventilators, incubators, anaesthetic machines, heart-lung machines, ECMO, and dialysis machines. ... diagnosis, prevention, monitoring, treatment or alleviation of disease,. *diagnosis, monitoring, treatment, alleviation of or ... cure or prevention of diseases in humans or other animals; intended to affect the structure or functions of the body of man or ...
Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... Allow organs like arteries and lungs to recoil. Elastic microfibril and elastin. extracellular matrix ... "Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125-139. doi:10.1016/j.numecd.2006.10.005. PMC 4426988. PMID ... Congenital diseases include Marfan syndrome and Ehlers-Danlos Syndrome.. *Myxomatous degeneration - a pathological weakening of ...
Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... Hodgson TS, Nielsen SM, Lesniak MS, Lukas RV (2016). "Neurological Management of Von Hippel-Lindau Disease". Neurologist ( ...
In individuals with this syndrome, the functioning of the lungs is usually normal but the mucus is abnormally viscous. The ... Young syndrome at NIH's Office of Rare Diseases Young's syndrome - General Practice Notebook Definition: Young syndrome from ...
In the end, the right ventricle is pumping blood to systemic circulation and to the lungs. However, this procedure carries a ... Altering the progression of left sided heart disease". Progress in Pediatric Cardiology. 22: 71-78. doi:10.1016/j.ppedcard. ...
... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... The physical examination typically includes an assessment of volume state, blood pressure, heart, lungs, peripheral arteries, ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ...
Incorrect application (e.g. into the lungs) results in pulmonary aspiration, which can sometimes be fatal if immediate medical ... Niigata Minamata disease. *Poisoning of Alexander Litvinenko. *Seveso disaster. *Consumption of Tide Pods ... Elliott CG, Colby TV, Kelly TM, Hicks HG (1989). "Charcoal lung. Bronchiolitis obliterans after aspiration of activated ...
Cardiovascular disease[edit]. Main articles: Occupational stress and Cardiovascular disease. Research has identified health- ... Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced encephalopathy (CSE) ... Centers for Disease Control and Prevention. Occupational Health Psychology (OHP). [1] *^ a b Everly, G.S., Jr. (1986). An ... In Schnall, P., Belkić, K., Landsbergis, P., et al (Eds.), The workplace and cardiovascular disease. Occupational Medicine, ...
lung disease. Pneumoconiosis (Asbestosis, Baritosis, Bauxite fibrosis, Berylliosis, Caplan's syndrome, Chalicosis, Coalworker's ... Pleural disease. Pleuritis/pleurisy Pneumothorax/Hemopneumothorax (Tension pneumothorax). Pleural effusion: Hemothorax · ... Viral · Bacterial (Pneumococcal, Klebsiella) / Atypical bacterial (Mycoplasma, Legionnaires' disease, Chlamydiae) · Fungal ( ...
A common antibacterial substance found in toothpaste may combat life-threatening diseases such as cystic fibrosis, or CF, when ... Ingredient in your toothpaste may combat severe lung disease. Contact(s): Chris Waters Microbiology and Molecular Genetics ... CF is a genetic disease with one in every 2,500 to 3,500 people diagnosed with it at an early age. It results in a thick mucus ... Tobramycin is currently the most widely used treatment for CF, but it typically doesnt clear the lungs of infection, Waters ...
Major Occupational Lung Diseases. Granulomatous Diseases. Chronic Beryllium Disease. Chronic beryllium disease (CBD) is an ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... immune-mediated granulomatous lung disease resembling sarcoidosis that is caused by exposure to the lightweight metal beryllium ...
Major Occupational Lung Diseases. Granulomatous Diseases. Hypersensitivity Pneumonitis. Hypersensitivity pneumonitis (HP), also ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... middle or lower lung predominance [Silva et al. 2008]. Some patients with chronic HP develop lung fibrosis, characterized by ... and bridging fibrosis can help differentiate HP from other fibrotic lung diseases. ...
Obstructive lung disease is a category of respiratory disease characterized by airway obstruction. Many obstructive diseases of ... Types of obstructive lung disease include; asthma, bronchiectasis, bronchitis and chronic obstructive pulmonary disease (COPD ... Following is an overview of the main obstructive lung diseases. Chronic obstructive pulmonary disease is mainly a combination ... Restrictive lung disease National Asthma Education and Prevention Program. Clinical Practice Guidelines. Expert Panel Report 2 ...
Interstitial lung diseases are a group of diseases that inflame or scar the lungs. Breathing in particles (asbestosis, ... Interstitial lung disease (Medical Encyclopedia) Also in Spanish * Interstitial lung disease - adults - discharge (Medical ... Interstitial Lung Disease (Mayo Foundation for Medical Education and Research) * Interstitial Lung Disease: Overview (National ... Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation and ...
WebMD breaks down the information and describes the types and causes of some common lung diseases. ... Various lung diseases affect the interstitium:. * Interstitial lung disease (ILD). This is a group of lung conditions that ... Lung diseases are some of the most common medical conditions in the world. Tens of millions of people have lung disease in the ... Lung diseases of the pleura include:. * Pleural effusion. Fluid collects in the space between your lung and the chest wall. ...
Likewise, successful prevention of lung diseases requires clear demarcation of the pre-disease state from the onset of disease ... the promotion of lung health and the prevention of lung disease. The lung continues to develop in postnatal, early childhood, ... chronic obstructive lung disease, cystic fibrosis, interstitial lung disease, and pulmonary hypertension. Generally, the ... Lung health and disease: These are dynamic states and need to be defined using biologic phenomena as a foundation. Health is ...
Our pulmonary specialists are highly experienced in caring for children with rare lung disorders. Explore our offerings and ... we are experts in managing conditions such as interstitial lung disease (ILD), surfactant mutations, lung development disorders ... Our Rare Lung Diseases Program is part of the Division of Pulmonary Medicine -- one of the nations top treatment centers for ... The Rare Lung Diseases Program at Cincinnati Childrens accepts referrals from both physicians and families. Call us at 513-636 ...
The disease gets its name from a distinctive blue-black marbling of the lung caused by accumulation of the dust. Georgius ... Black lung, respiratory disorder, a type of pneumoconiosis caused by repeated inhalation of coal dust over a period of years. ... respiratory disease: Silicosis and black lung disease. ,black lung). Initially the dust is deposited in the terminal ... Black lung, also called Black-lung Disease, or Coal-workers Pneumoconiosis, respiratory disorder, a type of pneumoconiosis ...
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Black lung disease is the common name for coal workers pneumoconiosis (CWP)or anthracosis, a lung disease of older workers in ... as a complication of black lung disease. Others develop a severetype of black lung disease called progressive massive fibrosis ... The risk of having black lung disease is directly related to the amount of dust inhaled over the years; the disease typically ... There is no treatment or cure for black lung disease, although it is possibleto treat complications such as lung infections and ...
... is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. ... Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by ... Pneumonia Fibrosis Hypersensitivity Pneumonitis Hypoxia Idiopathic Interstitial Lung Diseases Interstitial Lung Disease (ILD) ... Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease ...
... two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the ... Oxidative Stress and Smoke-Related Lung Diseases: A Tentative Approach Through the Blood, Lungs, and Gut ... and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant ... Nutrition in Inflammatory Lung Diseases Daisy Karina Aguilar-López, Carlos Olvera-Sandoval, Diego Estrada-Luna, Jeannett ...
This clinic focuses on the diagnosis and treatment of a wide variety of interstitial lung diseases including pulmonary fibrosis ... usual interstitial fibrosis, connective tissue-related lung disease ... connective tissue-related lung disease, rheumatoid lung, scleroderma lung, systemic lupus erythematosis related lung disease, ... Interstitial Lung Disease Program Appointment Line: 503 494-1620. This clinic focuses on the diagnosis and treatment of a wide ...
There are three main types of lung disease: ... disease is any problem in the lungs that prevents the lungs ... Lung disease is any problem in the lungs that prevents the lungs from working properly. There are three main types of lung ... Pulmonary fibrosis and sarcoidosis are examples of lung tissue disease.. *Lung circulation diseases -- These diseases affect ... Lung tissue diseases -- These diseases affect the structure of the lung tissue. Scarring or inflammation of the tissue makes ...
Lung Biology Research. Louisiana is one of the states in the U. S. which has high prevalence of pulmonary diseases, such as ... The Lung Biology laboratories seek to identify the novel mechanisms of lung inflammation and host defense, and explore how ... The Lung Biology group in the Schol of Veterinary Medicine (SVM) uses vertically integrated experimental cutting edge ... The scientific focus of the members working in Lung Biology range from innate immunity, adaptive immunity and immunotherapy. ...
Prevention of Dust Diseases of the Lung Br Med J 1948; 2 :399 ... Prevention of Dust Diseases of the Lung. Br Med J 1948; 2 doi: ...
Respiratory disease - Occupational lung disease: Silica dust produces a distinctive reaction in the lung that eventually leads ... distort and damage the lung. Silicosis is a hazard in any occupation in which workers are exposed to silica dust, particularly ... Occupational lung disease. Silicosis and black lung disease. Silica dust produces a distinctive reaction in the lung that ... The disease that results is known as byssinosis, or "brown lung." Workers in cotton plants in England used to complain of " ...
... latest diagnostic and therapeutic options for patients with the roughly 160 disorders categorized as interstitial lung diseases ... Interstitial Lung Disease Program. The Interstitial Lung Disease Program provides the latest diagnostic and therapeutic options ... Our Interstitial Lung Disease Program specializes in diagnosing and treating the full spectrum of interstitial lung diseases, ... Surgical lung biopsy: Surgery used in some cases to diagnose the type of lung disease. This is performed by a thoracic surgeon ...
Vitamin E Found In All Samples of Lung Tissue Taken from Injured Vapers November 8, 2019 at 6:19 pm Since the CDC began ... investigating the outbreak of "e-cigarette, or vaping, product use associated lung injury" (EVALI) in August, doctors have ...
Attendees heard a fascinating story of how disease detectives unraveled the mystery of popcorn-lung disease, and how we can ... Not Everything Is Better with Butter-flavoring: Popcorn Lung Disease and the Dangers of Diacetyl ... "We Were There" - Diacetyl and Popcorn Lung Disease. ... Popcorn Lung Disease and the Dangers of Diacetyl," at the ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Lung diseases can affect different parts of your lungs and respiratory system, causing problems like shortness of breath, chest ... What Are the Causes of Chronic Lung Disease?. Chronic lung diseases can originate from different sources. Diseases often ... What Are the Symptoms of Chronic Lung Disease?. Sometimes the symptoms of chronic lung diseases go unnoticed. You may think ... What Are the Types of Chronic Lung Disease?. Chronic lung diseases can affect your entire respiratory system, including the ...
Despite lung disease killing 4 million people every year, the Forum of International Respiratory Societies (FIRS) revealed ... Lung diseases. There are three main kinds of lung disease: * Lung circulation diseases - the blood vessels in the lungs are ... Restrictive lung disease: Types, causes, and treatment Restrictive lung disease is a class of lung disease that prevents the ... Restrictive lung disease: Treatment and symptoms Restrictive lung disease is a group of conditions that prevent the lungs from ...
A newly launched Rare Lung Diseases Consortium will spearhead cutting-edge research on rare lung diseases such as LAM, HPS and ... lung. For information on the Rare Disease Lung Consortium, visit https:/. /. www.. rarediseasesnetwork.. org/. cms/. rld/. ... Symptoms of the debilitating disease include shortness of breath, chest pain, chronic cough and lung collapse. As the disease ... Loyola University Medical Center is the only center in Illinois to join the newly launched Rare Lung Diseases Consortium, which ...
Call us for more information or to talk to an expert in the Rare Lung Diseases Program. ... Contact us if you have questions about the Rare Lung Diseases Program, the diseases we treat or the research we conduct. ... Rare Lung Diseases Program. Division of Pulmonary Medicine. 3333 Burnet Avenue. MLC 2021. Cincinnati, OH 45229 ... The Rare Lung Diseases Program at Cincinnati Childrens accepts referrals from both physicians and families. ...
... a group of diseases that make it difficult to get enough oxygen. Included is detail on types and complications. ... Interstitial lung disease may lead to cor pulmonale when the right ventricle has to pump harder to move blood through the lungs ... Interstitial lung disease is the name given to a group of conditions that cause inflammation and scar tissue in the lungs, ... What do the lungs do, and how do they function?. The lungs are complicated organs. Learn more about the way the lungs function ...
... lung disease symptoms and signs. Symptoms and signs include night sweats, shortness of breath, and cough. Pinpoint your ... home/lungs center/ lungs a-z list/symptom checker/nontuberculous mycobacterial lung disease symptoms symptoms ... Main Article on Nontuberculous Mycobacterial Lung Disease Symptoms. * Nontuberculous Mycobacterial Lung Disease. Nontuberculous ... lung disease. Nontuberculous mycobacteria (NTM) cause nontuberculous mycobacterial (NTM) lung disease. ...
Lungs are an important part of the respiratory system. Adults take 15 to 20 breaths a minute, which comes to around 20,000 ... Lung Institute: Stem Cell Therapy for Lung Disease. *Scientific American: If a persons lung size cannot increase, how does ... Chronic obstructive pulmonary disease (COPD) is long-term lung disease that prevents a person from breathing properly due to ... The right lung is shorter than the left lung to make room for the liver. The left lung is narrower than the right to make room ...
Occupational respiratory disease is any lung condition you get at work. It occurs because of repeated exposure to certain ... Occupational respiratory disease can lead to lung cancer and other diseases. People exposed to asbestos are at risk of ... What is occupational respiratory disease?. Occupational respiratory disease is any lung condition you get at work. It occurs ... Many substances found in the workplace can cause disease. This occurs when the toxins irritate the lining in your lungs. Common ...
... black lung, Farmers lung, mold, grasses, fumes, and autoimmune diseases. The most common symptoms are a dry cough and ... Treatment and prognosis depends upon the type of lung disease. ... is the name for a group of diseases that affect the lungs, for ... home / lungs health center / lungs a-z list / interstitial lung disease (interstitial pneumonia) center / interstitial lung ... Lung Disease/COPD Resources. *Could Shortness of Breath Be Lung Disease?. *Side Effects of New Treatments for CF: What You Need ...
  • But more serious, potentially fatal diseases join the ranks of CF including endocarditis, or inflammation of the heart, as well as infections from artificial hip and pacemaker implants. (
  • Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is caused by inhalation of antigens that trigger a diffuse mononuclear cell inflammation of the small airways and lung parenchyma. (
  • Scarring or inflammation of the tissue makes the lungs unable to expand fully (restrictive lung disease). (
  • The Lung Biology laboratories seek to identify the novel mechanisms of lung inflammation and host defense, and explore how these mechanisms may be exploited to develop novel treatment and prevention strategies. (
  • The Lung Biology group in the Schol of Veterinary Medicine (SVM) uses vertically integrated experimental cutting edge methodologies aimed at dissecting lung inflammation and host defense with expertise ranging from cell culture to animal (in vivo) models. (
  • Other types of lung disease may involve inflammation or scarring of lung tissue, which make it difficult to take a deep breath. (
  • Interstitial lung disease is the name given to a group of conditions that cause inflammation and scar tissue in the lungs, making it harder for them to work. (
  • A chest X-ray or CT scan can detect masses, fluid, or inflammation in your lungs. (
  • Interstitial fibrosis' is the term used to refer to the scarring of the lungs that can result from prolonged interstitial inflammation. (
  • All of these involve scarring or inflammation of the interstitial lung tissue and affect the volume of oxygen that can reach the bloodstream via the respiratory system. (
  • With support from the National Institutes of Health, investigators at National Jewish Health conduct extensive basic research into the mechanisms involved in the development and resolution of lung inflammation and fibrosis. (
  • Regulation of glutathione in inflammation and chronic lung diseases. (
  • Oxidant/antioxidant imbalance, a major cause of cell damage, is the hallmark for lung inflammation. (
  • Knowledge of the mechanisms of GSH regulation could lead to the pharmacological manipulation of the production and/or gene transfer of this important antioxidant in lung inflammation and injury. (
  • This article describes the role of AP-1 and ARE in the regulation of cellular GSH biosynthesis and assesses the potential protective and therapeutic role of glutathione in oxidant-induced lung injury and inflammation. (
  • This is an X-ray to check the lungs for signs of inflammation or swelling. (
  • Interstitial lung disease is a condition that causes inflammation and thickening of the lungs. (
  • The diseases cause inflammation or scarring of the lung tissue (interstitial lung disease) or result in filling of the air spaces with exudate and debris (pneumonitis). (
  • Bloom is small enough to enter the lungs' small air sacs, or alveoli, where the dust particles can cause an allergic reaction and inflammation. (
  • Corticosteroids provide relief from both acute and chronic symptoms by reducing inflammation in the lungs' air sacs. (
  • Recently, increasing evidence indicates that miRNAs play an important role in lung abnormalities, such as inflammation and oncogenesis. (
  • Researchers at Johns Hopkins University studied medical information from 6,302 adults on average 62 years old with the rare disease that leads to disabling and irreversible lung damage characterized by lung scarring and inflammation. (
  • The fibers will irritate the lung lining, which will cause chronic inflammation. (
  • Over time, this inflammation can lead to severe scarring of the lungs. (
  • After inhalation or ingestion, the asbestos fibers can become stuck in the lung tissue and cause inflammation and scarring over time, which can develop into asbestosis. (
  • Interstitial lung disease is a term that encompasses several diseases, but the common thread between them is severe scarring in the lungs due to inflammation. (
  • This inflammation in the lungs can be caused by a number of environmental factors such as asbestos exposure, silica dust, cotton dust, coal dust, and hard metal dust. (
  • Steroids administered orally led to marked improvement in patients with interstitial lung disease and necrotic nodules, but lacked effectiveness in several patients with severe airway inflammation or chronic bronchiolitis. (
  • It causes inflammation of the lungs leading to fibrosis. (
  • also called allergic alveolitis, bagpipe lung, or extrinsic allergic alveolitis, EAA) is an inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. (
  • asthma, bronchiectasis, bronchitis and chronic obstructive pulmonary disease (COPD). (
  • Although COPD shares similar characteristics with all other obstructive lung diseases, such as the signs of coughing and wheezing, they are distinct conditions in terms of disease onset, frequency of symptoms and reversibility of airway obstruction. (
  • Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive airways disease (COAD) or chronic airflow limitation (CAL), is a group of illnesses characterised by airflow limitation that is not fully reversible. (
  • The residual volume, the volume of air left in the lungs following full expiration, is often increased in COPD, as is the total lung capacity, while the vital capacity remains relatively normal. (
  • The increased total lung capacity (hyperinflation) can result in the clinical feature of a "barrel chest" - a chest with a large front-to-back diameter that occurs in some individuals with COPD. (
  • A chest x-ray is often ordered to look for hyperinflation and rule out other lung conditions but the lung damage of COPD is not always visible on a chest x-ray. (
  • Lung damage allows air to be trapped in your lungs in this form of COPD . (
  • Airway diseases include asthma , COPD and bronchiectasis . (
  • Louisiana is one of the states in the U. S. which has high prevalence of pulmonary diseases, such as pneumonia, asthma and Chronic Obstructive Pulmonary Diseases (COPD). (
  • Chronic obstructive pulmonary disease (COPD) is a term used to describe progressive lung diseases, including emphysema, chronic bronchitis and non-reversible asthma. (
  • Given that research shows that the mortality rate caused by COPD (chronic obstructive pulmonary disease) has almost doubled in the last thirty years, the lack of concern is even more dramatic, because the death rate of most other major diseases has been decreasing over the same period. (
  • 57% of respondents never had their lungs tested, even though simple lung tests, such as spirometry help doctors identify COPD, asthma , and other lung problems early on, when treatment is most effective. (
  • Women across the UK have been urged to heed warnings on the dangers of chronic obstructive pulmonary disease (COPD), after a new report reveals that many are not aware of the threat. (
  • Mr Dougal, NICHS' chief executive said: 'Better diagnosis and early intervention could reduce the local death rate, cut hospital admissions and save the health service some of the £47m it costs to treat respiratory illness - including Chronic Obstructive Pulmonary Disease (COPD) and asthma - in Northern Ireland each year. (
  • COPD is an umbrella term for a group of lung diseases that include chronic bronchitis, emphysema and small airways disease. (
  • Although experts have acknowledged a link between chronic obstructive pulmonary disease (COPD) and depression and anxiety , new research suggests the mood disorders may actually exacerbate COPD and cause increased hospitalizations. (
  • Unlike obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), which show a normal or increased total lung capacity (TLC), restrictive disease are associated with a decreased TLC. (
  • Chronic obstructive pulmonary disease, also called COPD, refers to emphysema and chronic bronchitis, which interfere with normal breathing. (
  • The American Lung Association says COPD is the fourth-leading cause of death in the United States, killing about 120,000 Americans a year. (
  • Specifically, the prevalence of GAD for adults aged 50 and older with chronic obstructive pulmonary disease (COPD) is much higher compared to older adults without COPD (5.8 percent vs 1.7 percent). (
  • University of Toronto researchers have published their findings in COPD: Journal of Chronic Obstructive Pulmonary Disease . (
  • COPD is an umbrella term for several chronic lung diseases including emphysema and chronic bronchitis. (
  • India not only has one of the highest disease burden for TB, drug resistant TB or TB-HIV, asthma, COPD, childhood pneumonia among others, but also is confronted with health system related complex challenges. (
  • India with other countries has committed to achieve Sustainable Development Goals (SDGs) by 2030, among which are targets to end TB and AIDS, achieve universal health coverage, substantially reduce the number of deaths and illnesses from hazardous air pollution and contamination, reduce deaths due to non-communicable diseases (like asthma or COPD) by one-third, among others", said Dr Salil Bendre, Vice-Chairman of NAPCON 2016. (
  • TB rates were found higher than previously estimated as per latest WHO Global TB Report 2016, asthma and COPD both are rising to emerge as leading cause of death among pulmonary diseases, and COPD is recognized as the second biggest killer among NCDs", said Dr Agam Vora, Secretary General of NAPCON 2016. (
  • Is CWP the same thing as chronic obstructive pulmonary disease (COPD)? (
  • But it may add to lung damage and contribute to the development of COPD. (
  • One of the most deadly lung conditions is called COPD, a catchall term that stands for chronic obstructive pulmonary disease. (
  • The airways are inflamed, narrowed and often filled with secretions in COPD patients, who are diagnosed by their symptoms, personal risk factors (smoking history), lung function tests and chest X-rays. (
  • It is a frustrating disease in terms of treatment, but if you can give the patient just a 10- to 15-percent improvement in lung function, that's a lot when every breath is an effort,' said Wanner, who also works with the COPD Foundation based in Miami. (
  • It differs from COPD in that asthma doesn't cause permanent damage to the lung tissue. (
  • Pulmonary rehabilitation (PR) is an excellent therapeutic option in another chronic lung diseases such as chronic obstructive pulmonary disease (COPD). (
  • Researchers say it could be used to keep an eye on chronic obstructive pulmonary disease (COPD) sufferers for early signs that their condition is getting worse. (
  • COPD is an umbrella term for a collection of conditions causing lung damage, such as chronic bronchitis and emphysema - in which the tiny air sacs, or alveoli, in the lungs are damaged. (
  • Chronic obstructive pulmonary disease (COPD) describes a group of lung conditions that cause the airways to narrow and become inflamed. (
  • Around 1.2million people in the UK are diagnosed with COPD, British Lung Foundation statistics show. (
  • And in the US, 16million people suffer from COPD, according to the Centers for Disease Control and Prevention. (
  • COPD is incurable and the damage to the lungs cannot be reversed. (
  • However, while many ingredients are not disclosed, it is difficult to mask the scent of chlorine bleach, now linked through scientific evidence to an increased risk of developing chronic obstructive pulmonary disease (COPD). (
  • COPD is a medical term covering progressive lung conditions such as emphysema, chronic bronchitis, nonreversible asthma and some forms of bronchiectasis. (
  • Individuals who suffer from diseases that fall under the umbrella term of COPD may experience frequent wheezing, coughing, chest tightness and increasing breathlessness. (
  • Diseases that fall under the umbrella term of COPD touch the lives of nearly 30 million people in the U.S., many of whom are unaware they are affected. (
  • There was also evidence in the literature that vitamin D plays a role in obstructive lung diseases such as asthma and COPD, and we now found that the association exists with this scarring form of lung disease too. (
  • Yet only about 25 percent of smokers develop chronic obstructive pulmonary disease (COPD). (
  • COPD , is a progressive lung disease which causes breathlessness and is often caused by cigarette smoke and air pollution. (
  • The Centers for Disease Control and Prevention reports that by 2020 the expected cost of medical care for adults in the US with COPD will be more than $90 billion, mainly due to complications and multiple hospitalizations, many of which are preventable with better healthcare management and more personalized and frequent patient support. (
  • COPD patient app, depicting the patient-physician disease-related communication (Courtesy of Ltd. (
  • Pulmonary rehabilitation offered to individuals with chronic respiratory diseases other than COPD has demonstrated improvements in symptoms, exercise tolerance, and quality of life. (
  • Smoking damages your lungs and increases your risk for a number of diseases including lung cancer and COPD. (
  • If you have a chronic lung disease like asthma or COPD, work with your doctor to manage symptoms and flare-ups. (
  • People with lung diseases such as asthma and COPD need to pay particular attention to the levels of air pollution called particulates - tiny solid or liquid particles - in the environment and limit their outdoor exposure when levels are high. (
  • Chronic Bronchitis and Emphysema constitute the condition, Chronic Obstructive Pulmonary Disease (COPD). (
  • Long-term damage to lung tissue by smoking can lead to the development of lung cancer as well as COPD. (
  • On the basis of damaged lung function, 1,093 people were identified to have COPD. (
  • Lead researcher Professor Robert West, said: "It is crucial to identify smokers with COPD and take urgent action to support them in stopping smoking because the most effective way of halting the progression of the disease is to stop smoking. (
  • It only requires a simple lung function test to find out whether they have COPD and this can be done by their GP. (
  • Dame Helena Shovelton, chief executive of the British Lung Foundation, appreciated the research, and said the charity would be launching a campaign in October to raise awareness of COPD. (
  • Play media Asthma is an obstructive lung disease where the bronchial tubes (airways) are extra sensitive (hyperresponsive). (
  • Airway diseases -- These diseases affect the tubes (airways) that carry oxygen and other gases into and out of the lungs. (
  • Some types of disease, like chronic asthma or bronchitis, cause problems with the airways that carry oxygen into your lungs and release carbon dioxide out of your lungs. (
  • The airways, air sacs, outer aspect of the lungs, and the blood vessels may be affected as well. (
  • The most common lung related conditions I see are reactive airways or asthma, as well as smoking-related emphysema, in my general practice," Dr. Jack Jacoub, a medical oncologist and director of thoracic oncology at Memorial Care Cancer Institute at Orange Coast Memorial Medical Center in Fountain Valley, California, told Live Science. (
  • Chronic obstructive pulmonary disease refers to a group of lung conditions such as emphysema and chronic bronchitis that cause a narrowing of airways in the lungs, making it hard to breathe, according to the National Institutes of Health. (
  • Although smoking-related carcinogens act on both proximal and distal airways inducing all the major forms of lung cancer, cancers arising in never smokers target the distal airways and favour adenocarcinoma histology. (
  • There is a different microbiome gene repertoire in the airways of cystic fibrosis patients with severe lung disease. (
  • Nodules may grow to a large size and hinder or stop the airflow in the lungs' airways. (
  • Each lung holds a dense network of airways that culminate in tiny, sac-like clusters called alveoli. (
  • This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems. (
  • ILD is different than lung diseases from obstructive airways. (
  • Interstitial lung disease affects bronchioles, which are the small airways in the lungs. (
  • P268 Is bronchiectasis severity influenced by aetiology or co-morbid airways disease? (
  • Bronchiolitis obliterans, also known as constrictive bronchiolitis or obliterative bronchiolitis is a respiratory disease caused by injury to the smallest airways, called bronchioles. (
  • Tissue oxygenation is significantly affected and thermal injury to the upper airways, lower airways, and lung parenchyma occurs. (
  • This is a group of lung conditions that includes sarcoidosis , idiopathic pulmonary fibrosis , and autoimmune disease . (
  • Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible form of lung disease that results in fibrosis, or scarring, of lung tissue for an unknown reason. (
  • Idiopathic pulmonary arterial hypertension (IPAH), formerly known as primary pulmonary artery hypertension, is a rare lung disorder characterized by high blood pressure in the pulmonary arteries (arteries that carry blood from the right side of the heart to the lungs). (
  • Interstitial lung disease includes types such as interstitial pneumonia, idiopathic pulmonary fibrosis, and sarcoidosis. (
  • Some cases of interstitial lung disease do not have an identifiable cause and are referred to as idiopathic. (
  • An international research team led by members of the University of Colorado School of Medicine faculty has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. (
  • Veracyte, Inc. announced the presentation of data demonstrating that the Envisia Genomic Classifier can help physicians more confidently diagnose interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), without the need for surgery. (
  • They include idiopathic fibrotic diseases, connective-tissue diseases, drug-induced lung disease, environmental exposures (inorganic and organic dusts), and primary diseases of the lungs (including sarcoidosis). (
  • In idiopathic pulmonary fibrosis (IPF), the antifibrotic drugs pirfenidone and nintedanib can delay disease progression. (
  • Idiopathic pulmonary fibrosis, or IPF, is a deadly lung disease and until now there were no effective treatments. (
  • Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. (
  • Egan JJ, Martinez FJ, Wells AU, Williams T. Lung function estimates in idiopathic pulmonary fibrosis: the potential for a simple classification. (
  • About 500,000 people have interstitial lung disease in the United States, with 132,000 to 200,000 having idiopathic pulmonary fibrosis, according to the Pulmonary Fibrosis Foundation . (
  • These air sacs make up most of your lung tissue. (
  • Silicosis is marked by the formation of lumps (nodules) and fibrous scar tissue in the lungs. (
  • Patients with complicated silicosis have noticeable shortness of breath, weight loss, and extensive formation of fibrous tissue (fibrosis) in the lungs. (
  • This clinic focuses on the diagnosis and treatment of a wide variety of interstitial lung diseases including pulmonary fibrosis, usual interstitial fibrosis, connective tissue-related lung disease, rheumatoid lung, scleroderma lung, systemic lupus erythematosis related lung disease, sarcoidosis, bronchiolitis obliterans, BOOP, and hypersensitivity pneumonitis. (
  • Lung tissue diseases -- These diseases affect the structure of the lung tissue. (
  • Pulmonary fibrosis and sarcoidosis are examples of lung tissue disease. (
  • Silica dust produces a distinctive reaction in the lung that eventually leads to the development of masses of fibrous tissue and distinctive nodules of dense fibrosis, which, by contracting, distort and damage the lung. (
  • At this stage there is little disability, but later the disease may progress to a more-generalized form, and in some instances large masses of fibrotic tissue form in the lung. (
  • There are many types of interstitial lung disease, all affecting the interstitium, which is the network of tissue running through both lungs. (
  • Lungs are sacks of tissue located just below the rib cage and above the diaphragm. (
  • The lobes are made of sponge-like tissue that is surrounded by a membrane called pleura, which separates the lungs from the chest wall. (
  • The diagnosis of interstitial lung disease typically involves imaging tests, measurement of blood oxygen levels, and sometimes, biopsies or tissue sampling. (
  • Interstitial lung disease results from a variety of causes that lead to thickening of the supporting tissue around the air sacs rather than the air sacs themselves. (
  • Patients with interstitial lung disease-a group of disorders causing progressive scarring of lung tissue-are often prescribed various medications that specifically target their disease and others that treat their symptoms. (
  • Management of interstitial lung disease associated with connective tissue disease. (
  • Jiang said nitrites - added to cured meats to prevent spoilage and provide color - may cause damage to lung tissue resembling emphysema, but added the study's design did not allow her to state definitively that the nitrites caused lung disease. (
  • Blood and tissue cultures eventually ruled out viral or bacterial causes of their lung injuries. (
  • The term interstitial lung disease (ILD) is used for a category of diseases characterized by damage to the pulmonary interstitial tissue (sometimes involving alveolar epithelium and pulmonary blood and lymph vessels). (
  • As the disease progresses, macules can develop into a coal nodule, an abnormality of the lung tissue. (
  • Connective tissue diseases. (
  • It causes a persistent cough and breathing difficulties, and leaves tell-tale scarring on lung tissue. (
  • The accumulating scar tissue can become so thick that the lungs may become severely impaired and can no longer properly expand when trying to inhale. (
  • Scar tissue buildup makes the arteries have to work harder to pump blood from the heart to the lungs. (
  • Occasionally, a biopsy of lung tissue may also be necessary to make a definitive diagnosis. (
  • ILD is actually a broad category of lung diseases that affect the tissue in the lungs around the air sacs and blood vessels. (
  • These tests can involve a biopsy of the lungs, where a tiny tissue sample is taken from the lungs to determine the condition of the lung. (
  • Examples include black lung disease from coal dust and asbestosis from asbestos dust. (
  • In advanced asbestosis, the lungs shrink, stiffen, and become honeycombed (riddled with tiny holes). (
  • The first disease recognized to be caused by asbestos was asbestosis , which produces characteristic changes in the lungs that can be identified in chest X-rays and that can impair lung function at an early stage. (
  • Later it was discovered that exposure to much less asbestos than was needed to cause asbestosis led to thickening of the pleura , and, when both cigarette smoking and asbestos exposure occurred, there was a major increase in the risk for lung cancer . (
  • Asbestos chrysotile fibres are responsible for the lung diseases known as asbestosis and mesothelioma. (
  • Asbestosis is an often-fatal lung disease produced by asbestos exposure. (
  • Similarly, they did not include in their burden estimate asbestosis, silicosis and coal workers' pneumoconiosis (black lung), because those conditions are entirely work-related. (
  • Examples of restrictive lung diseases include asbestosis, sarcoidosis and pulmonary fibrosis. (
  • Asbestosis, also known as diffuse pulmonary fibrosis, is a chronic lung condition that can develop years after exposure to asbestos. (
  • While asbestosis itself is not a type of cancer, over time, the condition can become more severe and present a higher risk of developing into an asbestos cancer like mesothelioma or lung cancer . (
  • Like other asbestos-related diseases, it can take many years for asbestosis to develop and begin to show symptoms. (
  • Digital clubbing is often a sign of low oxygen in the blood and can be linked to several lung and heart diseases, which is indicative that the asbestosis is leading to even more health complications. (
  • Since this added pressure makes the heart work harder, asbestosis patients can be at a high risk for heart disease or coronary artery disease. (
  • Asbestosis is often diagnosed with a chest X-ray or a CT scan, which can show scarring and damage to the lungs. (
  • Diagnosis can be challenging, and, as with other asbestos-related diseases, Asbestosis can be confused for other types of lung disease, especially if the patient has a history of smoking. (
  • It's also important for doctors to differentiate asbestosis from other forms of pneumoconiosis specifically, which are lung diseases caused by inhalation of toxic dust. (
  • There is no cure for asbestosis since it's impossible to reverse the damage to the lungs and the alveoli. (
  • Asbestosis can be effectively managed with some treatments and procedures that can help slow the progression of the disease, alleviate symptoms and enable patients to have a better quality of life. (
  • Asbestos can be a contributing factor to interstitial lung disease, which may itself be a precursor of asbestosis. (
  • Spirometry, a measurement of lung function, can provide an assessment of the severity, reversibility, and variability of airflow limitation, and help confirm the diagnosis of asthma. (
  • In addition to lung health, specific diseases under review and discussion included: asthma, bronchopulmonary dysplasia, chronic obstructive lung disease, cystic fibrosis, interstitial lung disease, and pulmonary hypertension. (
  • The lungs are over-engineered to accomplish the job that we ask them to do," said Dr. Jonathan P. Parsons, a professor of internal medicine, associate director of Clinical Services, and director of the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine at the OSU Asthma Center at The Ohio State University. (
  • Asthma , also called reactive airway disease before a diagnosis of asthma, is a lung disease where the air passageways in the lungs become inflamed and narrowed, making it hard to breath. (
  • Anti-IgE is a form of treatment for asthma management and allergic diseases. (
  • They are effective at improving asthma symptoms and lung function, but not to the same extent as inhaled steroids. (
  • I've found a site for anyone who has Asthma or other lung diseases and this lists plenty of information! (
  • Do you suffer from other lung diseases along with allergies and asthma? (
  • That's the reality for millions of Americans with emphysema, bronchitis, asthma and other lung diseases. (
  • Asthma is another major form of chronic lung disease. (
  • Chronic lower respiratory disease (CLRD), which includes bronchitis, emphysema, and asthma, is characterized by shortness of breath caused by airway obstruction. (
  • Asthma is a respiratory disease that can begin or worsen due to exposure at work and is characterized by episodic narrowing of the respiratory tract. (
  • Chronic lung disease may refer to: Asthma Bronchopulmonary dysplasia Chronic obstructive pulmonary disease, including chronic bronchitis and emphysema This disambiguation page lists articles associated with the title Chronic lung disease. (
  • PAP is characterized by the build-up of grainy material called surfactant in the alveoli (air sacs) of the lungs. (
  • The interstitium supports the alveoli or tiny air sacs in the lungs. (
  • There are around 480 million alveoli in the human lungs, according to the Department of Anatomy of the University of Göttingen . (
  • Air flows to and from the alveoli as lungs inflate and deflate during each respiratory cycle. (
  • As the disease worsens and the alveoli become thicker, they also begin to lose their elasticity. (
  • Chronic beryllium disease (CBD) is an immune-mediated granulomatous lung disease resembling sarcoidosis that is caused by exposure to the lightweight metal beryllium. (
  • Other conditions leading to chronic lung disease can include the replacement of previously transplanted lungs that have since failed, or bronchiectasis or sarcoidosis (the growth of tiny collections of inflammatory cells in different parts of the body), which adversely affect the lungs. (
  • Transbronchial and endobronchial lung biopsies may be diagnostic, particularly for sarcoidosis or lymphangitic spread of carcinoma but frequently are not useful for other diagnoses. (
  • Pigeon fanciers' lung goes by several other names, including allergic alveolitis, hypersensitivity pneumonitis, bird breeders' lung and pigeon breeders' disease. (
  • and noncaseating granulomas and/or mononuclear cell infiltrates on lung biopsy. (
  • Surgical lung biopsy: Surgery used in some cases to diagnose the type of lung disease. (
  • Before setting up the first appointment, we will work with families and referring physicians to obtain a patient summary, copies of laboratory and radiology films and reports, and lung biopsy slides. (
  • Diagnostic yield and postoperative mortality associated with surgical lung biopsy for evaluation of interstitial lung diseases: A systematic review and meta-analysis. (
  • lung biopsy is often unnecessary. (
  • Surgical lung biopsy is seldom necessary. (
  • Many patients require open or thoracoscopic lung biopsy to establish a definitive diagnosis. (
  • Currently, video-assisted thoracoscopic lung biopsy is the preferred method. (
  • The role of lung biopsy in the setting of high-resolution CT scan findings characteristic of specific disease entities remains controversial, with expert opinion weighing in on both sides. (
  • In 2000, a physician reported that eight former microwave-popcorn factory workers had developed a rare and disabling lung disease, bronchiolitis obliterans. (
  • Watson argued that the popcorn manufacturer Gilster-Mary Lee, as well as Kroger and Dillons grocery stores, should have put warning labels on their microwave popcorn , which he says is responsible for giving him a rare respiratory condition called bronchiolitis obliterans, also known as " popcorn lung . (
  • But the Food and Drug Administration classifies the chemical as "Generally Recognized as Safe," and before the diagnosis of Watson's bronchiolitis obliterans, which irreversibly damages small airway branches in the lungs, no link between the consumption of microwave popcorn and the respiratory condition had been found. (
  • Diacetyl has been directly linked to "bronchiolitis obliterans," which in serious cases can require lung transplants, according to Robert Kotloff, chair of pulmonary medicine at Cleveland Clinic. (
  • 1 , 2 Public health officials contacted NIOSH because a cluster of former employees of the facility had developed a rare lung disease called bronchiolitis obliterans. (
  • Diacetyl is the most dangerous of the three, since it has been linked to severe respiratory diseases such as bronchiolitis obliterans. (
  • 2) Varied patterns of interstitial lung disease, mainly bronchiolitis obliterans with organizing pneumonia, and pulmonary infiltrates and eosinophilia. (
  • Cystic fibrosis (CF) is a genetic (inherited) disorder in which a defective gene causes a thick, sticky buildup of mucus in the lungs (as well as other organs), causing wheezing or shortness of breath, chronic cough and frequent lung infections, such as bronchitis or pneumonia. (
  • Interstitial lung disease that can resemble pneumonia without an infection being present. (
  • Several terms related to interstitial lung disease have been used to describe this condition, including 'interstitial pneumonia . (
  • Smoking is also a risk factor for combined pulmonary fibrosis and emphysema (CPFE), rheumatoid-arthritis associated interstitial lung disease (RA-ILD), pulmonary alveolar proteinosis (PAP), acute eosinophilic pneumonia (AEP), and diffuse alveolar hemorrhage (DAH) in Goodpasture syndrome. (
  • If you have significant lung disease or are over 65, a pneumonia shot also is recommended. (
  • This thickening makes it difficult for the blood to absorb oxygen, which can lead to the symptoms of interstitial lung disease, such as breathlessness. (
  • The most common symptoms of interstitial lung disease are a dry cough and shortness of breath . (
  • What are signs and symptoms of interstitial lung disease? (
  • Learn the symptoms of interstitial lung disease. (
  • The most common symptoms of interstitial lung disease are shortness of breath, increased fatigue during exertion, coughing, and chest pains. (
  • Discordance between general and pulmonary pathologists in the diagnosis of interstitial lung disease. (
  • The diagnosis of interstitial lung disease can often be difficult because the symptoms are very similar to other lung conditions and diseases. (
  • Lung cancer. (
  • The risks from smoking and from significant asbestos exposure are multiplicative in the case of lung cancer. (
  • Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line) trial showed improved intracranial progression-free survival (PFS) and intracranial objective response rate (ORR) with ALUNBRIG (brigatinib) compared to crizotinib among anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) patients. (
  • Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved VIZIMPRO [vih-ZIM-pro] (dacomitinib), a kinase inhibitor for the first-line treatment of patients with metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test. (
  • Pollution from marine shipping causes approximately 60,000 premature cardiopulmonary and lung cancer deaths around the world each year, according to a study from the Rochester Institute of Technology . (
  • The researchers correlated the global distribution of particulate matter-black carbon, sulfur, nitrogen and organic particles-released from ships' smoke stacks with heart disease and lung cancer mortalities in adults. (
  • Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer. (
  • Long-term results and predictors of survival after surgical resection of patients with lung cancer and interstitial lung diseases. (
  • The finding, by Dr. Tatsuo Sano, an internationally known respiratory disease expert from Kawasaki, Japan, is considered both significant and troubling by the handful of cancer experts here familiar with the report. (
  • They did not study cancer of the lung and pleura, the membrane surrounding the lungs, because the occupational burden for those conditions, which can be substantial, has already been reported. (
  • Besides chronic obstructive pulmonary disease, pulmonary emphysema, and lung cancer, this group of diseases includes smoking-related interstitial lung disease (SR-ILD). (
  • About 25% of lung cancer cases worldwide are not attributable to tobacco smoking. (
  • Thus, lung cancer in never smokers is the seventh leading cause of cancer deaths in the world, killing more people every year than pancreatic or prostate cancers. (
  • Globally, lung cancer in never smokers demonstrates a marked gender bias, occuring more frequently among women. (
  • In particular, there is a high proportion of never smokers in Asian women diagnosed with lung cancer. (
  • Although multiple risk factors, including environmental, hormonal, genetic and viral factors, have been implicated in the pathogenesis of lung cancer in never smokers, no clear-cut dominant factor has emerged that can explain the relatively high incidence of lung cancer in never smokers and the marked geographic differences in gender proportions. (
  • The above-mentioned facts strongly suggest that lung cancer arising in never smokers is a disease distinct from the more common tobacco-associated forms of lung cancer. (
  • Although most lung cancers are a result of smoking, approximately 25% of lung cancer cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths each year. (
  • Figure 1: Epidemiological and histological features of lung cancer in never smokers. (
  • Figure 2: Pathogenesis of lung cancer in never smokers: targeting a specific anatomical compartment. (
  • Khuder, S. A. Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. (
  • Lung Cancer 31 , 139-148 (2001). (
  • Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. (
  • Characteristics of lung cancer in Korea, 1997. (
  • Lung Cancer 30 , 15-22 (2000). (
  • Your tax-deductible donation funds lung disease and lung cancer research, new treatments, lung health education, and more. (
  • CHICAGO -- Simple "gestalt" analysis of calcium deposits on coronary arteries, observed in lung screening CT scans, can alert doctors that patients who are at high risk for cancer also show risk of coronary disease, researchers suggested here. (
  • In a study in which cardiothoracic radiologists analyzed the level of coronary disease by simple CT observation as well as through more sophisticated Agatston scoring methods, there was no significant difference in stratifying patients to heavy, medium, or mild risk, said Caroline Chiles , MD, professor of radiology at the Wake Forest University Comprehensive Cancer Center, Winston-Salem, N.C. (
  • Individuals who are at high risk for lung cancer -- by virtue of their age and because they have a smoking history of more than 30 pack-years -- are also at risk of heart disease," she said in her oral presentation at the annual meeting of the Radiological Society of North America . (
  • The screening scan, she said, "not only gives us a chance to evaluate patients for lung cancer but for coronary artery calcification, which is a known predictor for cardiovascular events strongly correlated with age and smoking history. (
  • In her retrospective, case control study, patients were randomly selected from those undergoing lung cancer detection CT examinations. (
  • The patients were selected from a broader population of 53,452 individuals who underwent CT scans to detect lung cancer. (
  • These people who undergo these scans may realize that they are at a greater risk of lung cancer than the general public, but they may not realize they also have an increased risk of heart disease," Chiles said. (
  • She said that in the National Lung Screening Trial , the second leading cause of death behind lung cancer in that group was cardiovascular disease. (
  • A visual assessment of coronary artery calcification can be used for risk prediction of coronary heart disease death and all-cause mortality using non-gated low-dose CT for lung cancer screening, and is comparable to Agatston scoring. (
  • 28,600 Canadians were diagnosed with lung cancer. (
  • 21,100 Canadians died from lung cancer. (
  • 14,400 men were diagnosed with lung cancer and 11,100 died from it. (
  • 14,200 women were diagnosed with lung cancer and 10,000 died from it. (
  • On average, 78 Canadians were diagnosed with lung cancer every day. (
  • On average, 58 Canadians died from lung cancer every day. (
  • 1. Lung cancer statistics are estimates from: Canadian Cancer Society's Steering Committee: Canadian Cancer Statistics 2017. (
  • Radon gas (a naturally occurring radioactive gas produced by the breakdown of uranium in the ground) is a hidden killer and the second leading cause of lung cancer after smoking. (
  • Lung diseases (excluding lung cancer) were responsible for about 235,000 deaths. (
  • Numerous categories of ionizing radiation, chemicals and mixtures, occupational exposures, metals, dust and fibers have been linked to occurrence of lung cancer. (
  • Mesothelioma is a cancer of the mesothelium, part of which is the pleura, the lining of the lungs. (
  • Silicosis is a progressive disease that belongs to a group of lung disorderscalled pneumoconioses. (
  • There is no curative treatment for silicosis or black lung disease. (
  • More than 25,000 miners are seeking compensation from gold mining companies, saying they failed to protect them from Silicosis, a debilitating and incurable lung disease. (
  • Silicosis is caused by breathing crystalline silica dust -- a human lung carcinogen -- found in mines. (
  • Silicosis is a lung disease caused by inhalation of crystalline free silica dust. (
  • Breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. (
  • Black lung , also called Black-lung Disease , or Coal-workers' Pneumoconiosis , respiratory disorder, a type of pneumoconiosis caused by repeated inhalation of coal dust over a period of years. (
  • The disease gets its name from a distinctive blue-black marbling of the lung caused by accumulation of the dust. (
  • the symptoms usually appear only after 10-20 years of exposure to coal dust, and the extent of disease is clearly related to the total dust exposure. (
  • It is not clear, however, whether coal itself is solely responsible for the disease, as coal dust often is contaminated with silica, which causes similar symptoms. (
  • Black lung disease is the common name for coal workers' pneumoconiosis (CWP)or anthracosis, a lung disease of older workers in the coal industry, causedby inhalation, over many years, of small amounts of coal dust. (
  • the disease typically affects workers over age 50.Its common name comes from the fact that the inhalation of heavy deposits ofcoal dust makes miners lungs look black instead of a healthy pink. (
  • In the years since the federal government has regulated dust levels in coal mines, the number of cases of black lung disease has fallen sharply. (
  • The 1969 law also set up a black lung disability benefits program tocompensate coal miners who have been disabled by on-the-job dust exposure. (
  • The disease may advance, with increasing disability, for years after the person has stopped inhaling the dust. (
  • Coal dust alone, even if its silica content is very low, causes a distinctive pattern of change in the lung known as coal workers' pneumoconiosis (also called black lung ). (
  • A lung diseased usually linked to a person's employment and caused by breathing in too much silica dust. (
  • Also called black lung, this is a lung disorder caused by inhaling coal dust. (
  • Mucus cleans out the lungs and rids them of dust, germs and any other unwanted items that may end up in the lungs. (
  • Airborne particles from pigeon droppings may also contribute to pigeon fanciers' lung, but feather dust is the main culprit. (
  • More than 1 in 10 people with a range of non-cancerous lung diseases may be sick as a result of inhaling vapors, gas, dust or fumes at work, according to a joint American Thoracic Society and the European Respiratory Society statement published in the ATS's American Journal of Respiratory and Critical Care Medicine. (
  • Black lung----now referred to by experts as coal mine dust lung disease (CMDLD)--- was back in the news last week courtesy of the Pulitzer Prize. (
  • The disease is 100 percent preventable if coal mine operators implement and maintain effective dust controls. (
  • Labor Secretary Tom Perez, MSHA chief Joe Main, and NIOSH director John Howard will be announcing the release of new regulations designed to protect miners from developing coal mine dust lung disease. (
  • Black lung disease is a common name for any lung disease that develops from inhaling coal dust. (
  • Because CWP is a reaction to accumulated dust in the lungs, it may appear and get worse during your exposure to the dust or after your exposure has ceased. (
  • CWP starts with the inhalation and accumulation of coal dust in the lungs. (
  • When coal dust accumulates in the lungs, a coal macule may form. (
  • The disease is caused by environmental toxins, including asbestos or coal dust, but it also has been linked to autoimmune disorders, infections and medication side effects. (
  • One shows that lung function continues to get worse in miners with simple black lung even after they stop working and they're no longer exposed to the coal mine dust that causes the disease. (
  • Pneumoconiosis is a group of lung diseases caused by inhaled dust particles. (
  • Pneumoconiosis are occupational lung diseases that are caused due to accumulation of dust in the lungs and body's reaction to its presence. (
  • Fluid leaks out of the small blood vessels of your lung into the air sacs and the area around them. (
  • It most often happens in the main part of your lung, in or near the air sacs. (
  • Interstitial lung disease includes a group of diseases that have thickening of the supporting tissues between the air sacs of the lungs . (
  • Your lungs are part of a complex system, expanding and relaxing thousands of times each day to bring in oxygen and send out carbon dioxide. (
  • This makes it hard for the lungs to take in oxygen and release carbon dioxide. (
  • They affect the ability of the lungs to take up oxygen and release carbon dioxide. (
  • The lungs are large, elastic organs that supply the body with fresh oxygen and rid it of carbon dioxide gas. (
  • These tests will measure how well the lungs are working, the oxygen and carbon dioxide levels in the blood, and may also focus on how the lungs work during periods of exercise and sleep. (
  • Coal workers' pneumoconiosis, also known as Black Lung Disease. (
  • According to several of those who attended the meeting, Sano said he found a lung disease known as pneumoconiosis in X-rays of seven of 20 workers he examined in a small factory in Japan where fiberglass panels are made for housing construction. (
  • Other examples include minerals (such kaolin, talc, mica), beryllium lung disease, hard metal disease and silicon carbide pneumoconiosis. (
  • In early disease, the chest radiograph may be normal or show hilar adenopathy or parenchymal abnormalities. (
  • Chest radiographs are generally normal in early disease stages, but may show hyperinflation. (
  • The pleura is the thin lining that surrounds your lung and lines the inside of your chest wall. (
  • The Massachusetts General Hospital Interstitial Lung Disease Program multidisciplinary team includes lung specialists, chest radiologists, pulmonary pathologists, thoracic surgeons and research scientists. (
  • Lung diseases can affect different parts of your lungs and respiratory system, causing problems like shortness of breath, chest pain, chronic coughing and wheezing. (
  • Symptoms of the debilitating disease include shortness of breath, chest pain, chronic cough and lung collapse. (
  • NI Chest, Heart and Stroke is urging people to check their lungs for early signs of respiratory disease. (
  • Coronal and sagittal chest CT reconstructions (lung window) demonstrate the classic appearance of early lung involvement in scleroderma interstitial lung disease. (
  • Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. (
  • Diseases of these structures result in lung restriction, impaired ventilatory function, and respiratory failure (eg, nonmuscular diseases of the chest wall, neuromuscular disorders). (
  • The volume of FRC is determined by the balance of the inward elastic recoil of the lungs and the outward elastic recoil of the chest wall. (
  • Chest X-rays may reveal changes to lung structure. (
  • This is a chest X-ray demonstrating pulmonary fibrosis -- a form of interstitial lung disease -- due to the drug amiodarone used to treat an irregular heartbeart. (
  • Restrictive lung disease, a decrease in the total volume of air that the lungs are able to hold, is often due to a decrease in the elasticity of the lungs themselves or caused by a problem related to the expansion of the chest wall during inhalation. (
  • Symptoms of restrictive lung disease include cough, shortness of breath , wheezing and chest pain. (
  • A total of 44% of patients with any interstitial lung abnormalities reported cough, compared with 21% without abnormal findings on chest CT scans ( P =0.045), while 47% versus 21% had dyspnea ( P =0.025), according to Ivan O. Rosas, MD , of Harvard Medical School, and colleagues. (
  • Pleural plaques develop in the parietal pleura, the outer membrane of the lungs that also connects to the chest cavity. (
  • The chest x-rays are used to test for and rule out conditions like a collapsed lung and emphysema. (
  • In most cases, thickening of the pleura is not associated with disturbance of lung function or with symptoms of exposure to asbestos, although in occasional cases pleuritis is very aggressive and thus may produce symptoms. (
  • Each lung half has its own pleura sack. (
  • Restrictive lung diseases are characterized by a reduction in FRC and other lung volumes because of pathology in the lungs, pleura, or structures of the thoracic cage. (
  • The lung and pleura are also frequent sites of extraarticular involvement by RA, but may not result in significant symptoms. (
  • Pleural thickening is an asbestos-related disease that develops when the asbestos fibers cause intense scarring of the lungs, which thickens the lung lining (pleura). (
  • Pleural thickening develops in the visceral pleura, the delicate membrane lining the lungs, after the lungs become inflamed. (
  • Pleural thickening begins in the visceral pleura, the membrane covering the surface of each lung. (
  • Obstructive lung disease is a category of respiratory disease characterized by airway obstruction. (
  • Many obstructive diseases of the lung result from narrowing (obstruction) of the smaller bronchi and larger bronchioles, often because of excessive contraction of the smooth muscle itself. (
  • Cystic fibrosis is also sometimes included in obstructive pulmonary disease. (
  • Diagnosis of obstructive disease requires several factors depending on the exact disease being diagnosed. (
  • Following is an overview of the main obstructive lung diseases. (
  • Chronic obstructive pulmonary disease is mainly a combination of chronic bronchitis and emphysema, but may be more or less overlapping with all conditions. (
  • The analysis, being published in this week's Journal of the American Medical Association, looks at a class of medications known as inhaled anticholinergics that are used to treat chronic obstructive pulmonary disease. (
  • Those who ate cured meat products at least 14 times a month were 78 percent more likely to develop chronic obstructive pulmonary disease than people who did not eat these meats, even after the researchers sought to account for many other risk factors including smoking, overall diet and age. (
  • Also searched for Obstructive Pulmonary Diseases , Pulmonary Disease , Trials and more. (
  • 3 Because many of the cases have been associated with popcorn manufacturing plants, the term "popcorn lung" has often been used to describe the respiratory symptoms and fixed obstructive lung disease seen in these employees. (
  • Chronic obstructive pulmonary disease is a respiratory disease that can encompass chronic bronchitis and/or emphysema. (
  • 2019-09-24T22:18:43-04:00 The House Oversight and Reform Subcommittee on Economic and Consumer Policy held a hearing on the relationship between e-cigarettes and an outbreak in lung disease. (
  • Highlights from the Division of Lung Diseases 50th anniversary celebration in 2019. (
  • 2019) The Occupational Burden of Nonmalignant Respiratory Diseases. (
  • tuberculosis is also more common in victims of black lung. (
  • The Center for Public Integrity's Chris Hamby received the prestigious recognition for his reporting on the steep hurdles faced by coal miners who seek black lung disability compensation. (
  • It's a rule to prevent black lung disease. (
  • Most miners aren't eligible for federal black lung benefits. (
  • For information on organizations dealing with mining and black lung disease, see the Other Places to Get Help section of this topic. (
  • Hundreds of coal miners are suffering from the advanced stage of the fatal disease commonly called black lung. (
  • BERKES: Almberg and co-author Robert Cohen identified for the first time thousands of cases of severe black lung in the last 50 years. (
  • BERKES: Cohen and Almberg looked at every coal miner's claim for federal black lung benefits since 1970 and counted those that were proven to involve the advanced stage of black lung, known as progressive massive fibrosis, or PMF. (
  • BERKES: Two other studies involve the damage black lung disease does to the lungs. (
  • The other study was released two weeks ago and documents a threefold increase in the rate of lung transplants due to black lung, according to David Blackley of the National Institute for Occupational Safety and Health. (
  • BLACKLEY: We see increasing numbers and increasing rates of lung transplants, but if you look further down the chain of severity, within our surveillance program, we're seeing more early stage black lung. (
  • It may involve medicines, oxygen therapy, or a lung transplant in severe cases. (
  • Lung diseases can also affect the ability of your lungs to circulate oxygen and blood throughout your respiratory system and to your heart. (
  • As the disease progresses, many patients must go on oxygen, and some require lung transplants. (
  • Interstitial lung disease that has been present for a long time may cause signs and symptoms related to lowering of the oxygen levels in the blood, such as clubbing of the fingertips and enlargement of the heart. (
  • finally a new doctor sent me to have lung function test,which revealed my lungs was only a third of what they should be,and my oxygen level at night was like 66% i was diagnosed with this,along with sleep apnea(after study)and now have a cpap,and oxygen. (
  • A pulmonologist, a doctor who specializes in diseases of the lung, will treat you and help you to manage your medications and oxygen therapy. (
  • Prompt treatment is necessary for complicating pulmonary disease such as cor pulmonale (oxygen, diuretics), pulmonary embolism (anticoagulants), and infection (antibiotics). (
  • Many have oxygen machines in their homes and use them frequently to get the fresh air that their lungs can no longer provide. (
  • Clinical trials are expected to begin in early 2018 at the Zurich University Hospital and will initially involve up to 100 participants wearing Internet of Things (IoT) devices, which will record their symptoms and vital-signs, such as cough intensity, sputum (salvia and mucus) color, lung function, breath rate and heart rate, oxygen saturation, as well as their activity. (
  • Do something active for 30 minutes each day to lighten the load on your lungs and increase the efficiency of oxygen transportation and metabolism. (
  • These parts of the lung become inflamed and/or scarred, which leads to problems with getting oxygen out of the air and into the bloodstream. (
  • Diagnosing and caring for children with rare lung diseases is our specialty. (
  • Kuwaiti children with rare lung disease find help at Cincinnati Children's. (
  • Our Rare Lung Diseases Program is part of the Division of Pulmonary Medicine -- one of the nation's top treatment centers for pulmonary disorders. (
  • The Rare Lung Diseases Program at Cincinnati Children's accepts referrals from both physicians and families. (
  • We have compiled a list of support and information resources to help you better understand your child's rare lung disease. (
  • MAYWOOD, Ill. -- Loyola University Medical Center is the only center in Illinois to join the newly launched Rare Lung Diseases Consortium, which will spearhead cutting-edge research on rare lung diseases. (
  • and educate patients, physicians, researchers and the public about rare lung diseases. (
  • The consortium is interested in more than 20 rare lung diseases, and initially will study these three: lymphangioleiomyomatosis (LAM), Hermansky-Pudlak sydrome (HPS) and pulmonary alveolar proteinosis (PAP). (
  • Contact us if you have questions about the Rare Lung Diseases Program, the diseases we treat or the research we conduct. (
  • Physicians wishing to refer patients to us can contact the Rare Lung Diseases Program at 513-803-1332. (
  • It is the first FDA-approved treatment for this rare lung condition. (
  • PARIS: Doctors treating a patient with a rare lung disease usually caused by exposure to industrial metals say it may instead be the first case linked to vaping. (
  • It is often difficult to make a diagnosis from symptoms alone, since so many lung diseases can present with shortness of breath and cough. (
  • Despite their rarity, these diseases are of great importance for the medical care of smokers who present with dry cough and/or exercise-induced dyspnea. (
  • A patient is considered beryllium sensitized when they have a positive blood BeLPT but no abnormal lung pathology. (
  • A detailed analysis of the pathology of the various interstitial lung diseases is also provided. (
  • Patients typically inhale the drug, yet find themselves chronically infected their whole lives, eventually needing a lung transplant. (
  • Such findings may be seen in patients with acute, subacute or chronic disease. (
  • 2008]. Some patients with chronic HP develop lung fibrosis, characterized by reticular abnormality, traction bronchiectasis, and sometimes honeycombing, often in association with centrilobular nodularity, ground glass, or mosaic attenuation. (
  • Seeing an average of 200 patients a year, we are experts in managing conditions such as interstitial lung disease (ILD), surfactant mutations, lung development disorders and lymphatic disorders. (
  • Patients will receive information regarding the latest medical treatment and ongoing clinical research trials, as well as discussion of lung transplantation. (
  • The Interstitial Lung Disease Program provides the latest diagnostic and therapeutic options for patients with the roughly 160 disorders categorized as interstitial lung diseases, also known as pulmonary fibrosis. (
  • Patients with Alpha 1 lung disease are treated with augmentation therapy which is an intravenous infusion of alpha-1 antitrypsin protein (AAT) from the blood plasma of healthy human donors. (
  • FIRS urges patients with lung diseases to talk to their doctors and other healthcare professionals about physical activity options. (
  • Researchers have identified that dysfunction of a specific immune cell, called B cells, underlies lung disease that affects patients with the rare immunological disorder known as common variable immunodeficiency. (
  • As one of the largest interstitial lung disease referral centers in the United States, we have access to patients, biological samples and animal models that can help solve the mysteries of these complex diseases and improve care for patients who suffer from them. (
  • The NHLBI offers many resources related to lung diseases and sleep disorders, including publications and videos, to help patients, their families, and health professionals. (
  • The pulmonary research community, along with advocates, health care providers, and patients have honored and celebrated the 50th anniversary of the NHLBI's Division of Lung Diseases (DLD). (
  • Interstitial lung disease and pulmonary hypertension (PH) are the most common cardiopulmonary findings in patients with systemic sclerosis (SSc). (
  • About two thirds of patients suffering from SSc develop scleroderma interstitial lung disease. (
  • PH is present in about 20% of SSc patients and is typically associated with severe lung disease, although it may be an isolated manifestation of SSc. (
  • There are four roles of imaging in scleroderma interstitial lung disease: 1) detection of lung involvement, 2) identification of patients likely to respond to treatment, 3) assessment of treatment efficacy, and 4) exclusion of other significant diseases to include PH and cardiac and esophageal abnormalities. (
  • This finding offers researchers the opportunity to develop new treatments for IPF, a disease that typically leads to death three to five years after diagnosis in almost 50 percent of patients. (
  • Many of the patients who used to die from heart disease now live longer, so they have a higher risk of developing IPF. (
  • rather, doctors treat the patients' recurrent sinus, ear and lung infections with antibiotics and therapies to relieve symptoms. (
  • A trial of the innovative top - which patients say is comfortable - found it was just as accurate at recording lung activity as traditional tests. (
  • Investigators looked at results involving 1,570 individuals, including 210 who died of coronary disease and 314 patients who died of other causes, leaving 1,046 patients alive at the end of the trial. (
  • She said that the study could be used to influence treatment for coronary artery disease because patients with high calcium scores are more likely to be prescribed statins and aspirin therapy and are told to change lifestyle and diet. (
  • Patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) tend to have a distinct clinical phenotype that includes older age, respiratory symptoms, and worse RA overall -- and are at substantial risk for early mortality, researchers reported. (
  • These patients' mortality risk is three times higher than that of RA patients without pulmonary disease, and that risk has been increasing even as overall RA mortality has declined. (
  • Patients with radiologically severe abnormalities were significantly older than those without abnormalities (65 versus 53 years, P =0.0037) and had more severe disease, as evidenced by RF levels of 415 versus 90 U/mL ( P =0.018), anti-CCP positivity (82% versus 43%, P =0.039), and more swollen joints (11 versus 6, P =0.046). (
  • In both groups, the 6-minute walk distance was considerably greater for patients without lung abnormalities, although this wasn't statistically significant. (
  • In this study, patients with interstitial lung disease had much higher rates of anti-CCP positivity, which provides additional support for smoking cessation as a vital aspect of disease control, according to the researchers. (
  • Once properly diagnosed, patients will also likely undergo breathing or lung function tests to better assess the extent of the damage to the lungs. (
  • As most chronic diseases progress outside the hospital we need a secure way to monitor patients when they are discharged," said Dr. Ulrich Muehlner, CEO, (
  • In the future, the algorithms derived from these patterns could be useful to identify the status and progression of the disease and to predict acute events, called exacerbations, where patients nearly suffocate and require re-hospitalization. (
  • We believe that machine learning algorithms may someday be able to help doctors and patients predict and prevent exacerbations of the disease and also provide personalized virtual coaching to improve medication adherence and activity level," states Thomas Brunschwiler , IBM Research scientist and project leader. (
  • Anti-inflammatory medications are commonly prescribed to patients with interstitial lung disease as well. (
  • A Yugoslavian study of six non-smoking asbestos exposure patients showed that interstitial lung disease could be detected early through tests of the flow rate of air through bronchioles and high resolution CT scans. (
  • Respiratory involvement in patients with inflammatory bowel disease (IBD) has been reported mainly since 1976. (
  • Patients with IBD can develop varied inflammatory complications in the lung, and a sizable fraction of these complications is steroid-sensitive. (
  • About 7% of patients have parental consanguinity, and in nearly 10% of cases, siblings are afflicted with similar diseases. (
  • Centers for Disease Control and Prevention. (
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (
  • The committee heard testimony from Centers for Disease Control and Prevention Principal Deputy Director Dr. Anne Schuchat about the health effects of e-cigarette use and what officials knew about a string of lung illnesses resulting from e-cigarettes and vaping. (
  • This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. (
  • The goal of therapy is to stop or slow the progression of lung destruction. (
  • She said more research is needed to determine whether increasing blood vitamin D levels can prevent or slow progression of the lung disease. (
  • It's kind of a relentless and increasing progression of disease. (
  • Treatments help slow the progression of the disease and ease symptoms. (
  • On Wednesday, January 30th the "We Were There" lecture series presented "Not Everything Is Better with Butter-flavoring: Popcorn Lung Disease and the Dangers of Diacetyl," at the Roybal Campus, Alexander D. Langmuir Auditorium . (
  • Attendees heard a fascinating story of how disease detectives unraveled the mystery of popcorn-lung disease, and how we can protect workers from permanent lung damage caused by diacetyl in butter flavoring. (
  • The disease, also known as "popcorn lung," got its name from workers who developed the disease after inhaling diacetyl while working in popcorn factories, according to Kotloff. (
  • This irreversible lung disease is more commonly known as "popcorn lung," due to a high incidence in former workers at microwave popcorn plants. (
  • Four of the eight workers were ill and put on lung transplant waiting lists. (
  • Lung transplant recipients who participated in a three-month structured exercise regime when they left hospital were found to have significantly superior quality of life and a lower chance of developing cardiovascular problems, compared to those who didn't, Belgian researchers reported in the American Journal of Transplantation . (
  • Without a lung transplant, HPS typically is fatal within 10 years of onset. (
  • Almost everyone with a breathing problem can benefit from pulmonary rehabilitation, even those with an advanced stage of lung disease or awaiting a lung transplant . (
  • In severe cases where the lungs are extremely damaged, a lung transplant might be recommended. (
  • Kraft M. Approach to the patient with respiratory disease. (
  • Occupational respiratory disease is any lung condition you get at work. (
  • How is occupational respiratory disease diagnosed? (
  • Talk to your doctor if you think you have occupational respiratory disease. (
  • Tests can diagnose occupational respiratory disease. (
  • Can occupational respiratory disease be prevented or avoided? (
  • Depending on your line of work, you might not be able to avoid occupational respiratory disease. (
  • There is no cure for occupational respiratory disease. (
  • The best overall source for statistics on respiratory diseases in Canada is the report called Life and Breath: Respiratory Disease in Canada, released in November 2007. (
  • They combine knowledge of the latest treatments with findings from advanced research to their care of children with the most complex lung diseases. (
  • There is currently no cure for IPF or treatments that can remove the scarring from the lungs. (
  • Drug discovery studies and novel treatments of siRNAs are currently targeting a wide range of diseases, including various viral infections and cancers. (
  • Inhaled resveratrol treatments could slow ageing-related degenerative changes in mouse lung. (
  • Pulmonary rehabilitation includes exercise and education classes to improve your knowledge and understanding of your lung disease and prescribed treatments. (
  • Other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. (
  • There are various occupational lung diseases. (
  • It is the oldest known occupational lung disease, and is caused by exposure to inhaled particles of silica, mostlyfrom quartz in rocks, sand, and similar substances. (
  • In "The Occupational Burden of Nonmalignant Respiratory Diseases: An Official American Thoracic Society and European Respiratory Society Statement," 13 clinical and research experts from the two respiratory societies analyzed scores of studies of the connections between occupational hazards and lung disease. (
  • The role of occupational factors in most lung disease is under-recognized," said Paul D. Blanc, MD, MSPH, chief of the Division of Occupational and Environmental Medicine at the University of California San Francisco, who along with Carrie A. Redlich, MD, MPH, director of the Occupational and Environmental Medicine Program at Yale University, led the group effort. (
  • Five of South Africa's largest gold mining companies recently announced they will create a working group to deal with the issue of occupational lung disease. (
  • In November, five of South Africa's biggest mining companies said they would create a working group on occupational lung disease. (
  • Occupational lung diseases are occupational, or work-related, lung conditions that have been caused or made worse by the materials a person is exposed to within the workplace. (
  • Inhalation of tobacco smoke is a risk factor for various diseases of the lungs and respiratory tract. (
  • Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. (
  • According to the American Thoracic Society , there are more than 200 different lung disorders that affect the interstitium. (
  • Interstitial lung disease (ILD) is a broad group of lung diseases comprising of more than a hundred distinct disorders. (
  • The NHLBI leads or sponsors many studies to advance our knowledge and treatment of lung diseases and sleep disorders-and you can help. (
  • Learn more about NHLBI funding opportunity announcements (FOAs) for research on lung diseases and sleep disorders. (
  • Contact us with questions or to order resources on lung diseases and sleep disorders from the NHLBI. (
  • If caused by parenchymal lung disease, restrictive lung disorders are accompanied by reduced gas transfer, which may be marked clinically by desaturation after exercise. (
  • The many disorders that cause reduction or restriction of lung volumes may be divided into two groups based on anatomical structures. (
  • The second is extrinsic disorders or extrapulmonary diseases. (
  • 40. Interstitial Lung disease in Childhood Rheumatic Disorders. (
  • 42. Lymphoproliferative Disorders of the Lung. (
  • Adenoviral Vectors for Gene Therapy of Inherited and Acquired Disorders of the Lung, David T. Curiel and Robert I. Garver, Jr. (
  • One form is caused by heart failure and back pressure in your lungs' blood vessels. (
  • These blood vessels can have diseases, as well. (
  • Lung circulation diseases -- These diseases affect the blood vessels in the lungs. (
  • Chronic lung diseases can affect your entire respiratory system, including the blood vessels and muscles that allow you to breathe. (
  • Shortness of breath affects the breathing passages and the lungs, the heart, or blood vessels. (
  • Pigeon Breeders & Lung Disease" last modified May 13, 2017. (
  • Which procedures are performed in the diagnosis of diffuse parenchymal lung diseases (DPLDs)? (
  • Inter-observer variation between pathologists in diffuse parenchymal lung disease. (
  • Which medications are used in the treatment of diffuse parenchymal lung diseases (DPLDs)? (
  • The mnemonic "PAINT" has been used to divide the causes of restrictive lung disease into pleural, alveolar, interstitial, neuromuscular, and thoracic cage abnormalities. (
  • As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. (
  • After investigating numerous possible sources, researchers ultimately determined the cause of lung damage: a vapor from butter flavoring added to the popcorn. (
  • In recent years researchers working with laboratory animals and very fine fiberglass fibers have been able to produce tumors in the lung linings of animals by surgically implanting the fibers. (
  • WASHINGTON (Reuters) - People who frequently eat cured meats such as ham, hot dogs and bacon face a higher risk of lung disease, researchers said on Monday, citing additives called nitrites as a possible cause. (
  • Researchers sought to learn about potential treatable factors related to early signs of the scarring disease seen by CT scans. (
  • After studying genes and lung health in over 7,600 people, researchers found one specific gene variant that was strongly associated with impaired lung function. (
  • In Nature Genetics , researchers linked lung function with a number of gene variants. (
  • In 2016, researchers published an in-depth review showing genetic connections with several lung conditions. (
  • The saliva and lung function test results were examined by the researchers. (
  • Millions of Americans suffer from chronic lung diseases, and they are some of the leading causes of disease-related death. (
  • Tobramycin is currently the most widely used treatment for CF, but it typically doesn't clear the lungs of infection, Waters said. (
  • A lung infection occurring within the interstitium. (
  • The most common type of NTM lung infection in the United States is due to the group of bacteria in the M. avium complex (MAC). (
  • Signs and symptoms of NTM lung disease depend on the severity of the infection. (
  • But one person may develop a viral infection and go on to enjoy healthy lungs, while another develops lung disease. (
  • Pleural thickening, also called diffuse pleural thickening or DPT, is most commonly a result of asbestos exposure, though it can also develop following other health conditions like infection and various lung diseases. (
  • Georgius Agricola , a German mineralogist, first described lung disease in coal miners in the 16th century, and it is now widely recognized. (
  • The disease is most commonly found among miners of hard coal , but it also occurs in soft-coal miners and graphite workers. (
  • Althoughpeople who live in cities often have some black deposits in their lungs frompolluted air, coal miners have much more extensive deposits. (
  • They also found sharp increases in disease year after year, as much as 30 percent in the central Appalachian coal-mining states of Kentucky, Virginia and West Virginia. (
  • BERKES: At least 62 coal miners with seriously advanced disease have had lung transplants, nearly 80 percent in just the last decade. (
  • How do doctors test for and diagnose interstitial lung disease (ILD)? (
  • A common antibacterial substance found in toothpaste may combat life-threatening diseases such as cystic fibrosis, or CF, when combined with an already FDA-approved drug. (
  • Findings of lymphocytic infiltration, giant cells, poorly formed granulomas, and bridging fibrosis can help differentiate HP from other fibrotic lung diseases. (
  • CF may ultimately lead to extensive lung damage and respiratory failure. (
  • Symptoms and signs of interstitial lung disease occur because the damage to the interstitium of the lung impairs breathing function. (
  • Over a long period, lung damage impairs the flow of air in and out of the lungs. (
  • But can an unrestrained gusto for that moment cause permanent lung damage? (
  • Left untreated, chronic pigeon breeders' disease can cause permanent lung damage. (
  • It usually develops due to long-term damage to the lungs from smoking or air pollution. (
  • Also called chronic respiratory conditions, these diseases damage lungs to the point that it's difficult to breathe. (
  • One thing they share, though, is that they can lead to lung damage that reduces quality of life. (
  • The particulate matter in wood and waste can seriously damage your lungs. (
  • It results in a thick mucus in the lungs, which becomes a magnet for bacteria. (
  • The U.S. Food and Drug Administration today approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. (
  • Lung function is essential for good health and compromises in this capacity have a large and broad effect on the ability to lead a full and satisfying life. (
  • The lung continues to develop in postnatal, early childhood, and young adult life, after which time lung function declines with aging. (
  • These diseases may also affect heart function. (
  • Spriometry is a kind of lung-function (pulmonary function) test. (
  • This amount of consumption also was associated with poorer overall lung function, according to a study involving data on 7,352 Americans age 45 or older. (
  • They improve symptoms of lung disease and increase lung function. (
  • Apart from clinical examination and determination of lung function, the most important instrument in the diagnosis of ILD is high-resolution computer tomography. (
  • Lung function tests may be used to determine how badly the lungs are damaged. (
  • The loss of lung function is progressive -- though it's slow in some and faster in others. (
  • A smart shirt which measures lung function and pings data straight to a mobile app could help monitor people with killer lung diseases. (
  • Traditional lung function tests are usually done in a clinic with equipment such as an exercise bike, facemask and computer. (
  • Evaluations of employees working in the plant revealed high rates of both respiratory symptoms and abnormal lung function. (
  • A chronic lung disease is any disease that damages your lungs and affects their function. (
  • It's thought that certain genes could be associated with lung function, however. (
  • They added that genetics affected lung function regardless of other risk factors, like smoking. (
  • and a previous study from 2013 found that they impede lung function with short-term use the same way normal cigarettes do. (
  • The imaging tests and lung function tests together will better enable a doctor to come up with the appropriate treatment plan. (
  • Lung function test results (your physician can fax this to 619-543-7345 ). (
  • The diagnosis of this lung disease requires tests such as x-rays, CT scans, and pulmonary function tests. (
  • In Pulmonary Arterial Hypertension and Interstitial Lung Disease: A Clinical Guide, renowned experts provide a state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. (
  • National Jewish Health has a tremendous clinical research program whose investigators seek to systematically advance understanding of interstitial lung disease (ILD), including its epidemiology, natural history, and prognosis. (
  • Approach to the adult with interstitial lung disease: Clinical evaluation. (
  • Smoking-related interstitial lung diseases (SR-ILDs) are a heterogeneous group of diseases with major clinical significance. (
  • There are major clinical differences between lung cancers arising in never smokers and smokers and their response to targeted therapies. (
  • Striking differences in the epidemiological, clinical and molecular characteristics of lung cancers arising in never smokers versus smokers have been identified, suggesting that they are separate entities. (
  • This offers intriguing opportunities, not only for promotion of healthy lungs, but also for interventions for development of healthier lungs by accelerating growth and/or slowing decline. (
  • Emergency public health measures must be in place because healthy lungs are an indispensable need if we want a healthy country' said Director Professor (Dr) KC Mohanty, Organizing Chairman of 18th Joint National Conference on Pulmonary Diseases (NAPCON 2016) in Mumbai, India. (
  • Four cases of severe lung injury in the Twin Cities are being linked to vaping and e-cigarette use, prompting state health officials to warn the public about the harm of these products and to advise doctors to be on the lookout. (
  • A recent study published in the journal Environmental Health Perspectives specifically examined the chemical flavorings in leading e-cig brands, and found that more than half contain diacetyl, a chemical associated with severe lung disease. (
  • Information on this illness in Virginia can be found on the Virginia Department of Health page on Severe Lung Illness Associated with Vaping . (