Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Tumors or cancer of the LUNG.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
The transference of either one or both of the lungs from one human or animal to another.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
A malignant epithelial tumor with a glandular organization.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Infection of the lung often accompanied by inflammation.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The circulation of the BLOOD through the LUNGS.
The excision of lung tissue including partial or total lung lobectomy.
Inhaling and exhaling the smoke of burning TOBACCO.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
A cell line derived from cultured tumor cells.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
An abnormal increase in the amount of oxygen in the tissues and organs.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Endoscopic examination, therapy or surgery of the bronchi.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A pathological accumulation of air in tissues or organs.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Measurement of volume of air inhaled or exhaled by the lung.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Functional competence of specific organs or body systems of the FETUS in utero.
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Established cell cultures that have the potential to propagate indefinitely.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A naturally radioactive element with atomic symbol Rn, atomic number 86, and atomic weight 222. It is a member of the noble gas family found in soil, and is released during the decay of radium.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Epithelial cells that line the PULMONARY ALVEOLI.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Refers to animals in the period of time just after birth.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Diseases caused by factors involved in one's employment.
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Any hindrance to the passage of air into and out of the lungs.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The volume of air remaining in the LUNGS at the end of a maximal expiration. Common abbreviation is RV.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Infections with bacteria of the genus PSEUDOMONAS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Relatively complete absence of oxygen in one or more tissues.
Measurement of oxygen and carbon dioxide in the blood.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
The upper part of the trunk between the NECK and the ABDOMEN. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Mechanical devices used to produce or assist pulmonary ventilation.
The measurement of an organ in volume, mass, or heaviness.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The act of BREATHING in.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An abnormality in lung development that is characterized by a multicystic mass resulting from an adenomatous overgrowth of the terminal BRONCHIOLES with a consequent reduction of PULMONARY ALVEOLI. This anomaly is classified into three types by the cyst size.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)
The act of BREATHING out.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
Antibodies produced by a single clone of cells.
Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Virus diseases caused by the ORTHOMYXOVIRIDAE.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Hypersensitivity pneumonitis: experimental production in calves with antigens of Micropolyspora faeni. (1/31967)

Pneumonitis was induced in calves by exposure to aerosols of Micropolyspora faeni with or without prior sensitization of the animals by subcutaneous injection of antigen. The pneumonitis primarily involved centrolobular areas and was characterized by alveolar septal thickening and loss of air space by cellular infiltration. Vasculitis and focal haemorrhage occurred in certain individuals and haemoproteinaceous exudate appeared within septa and alveolar lumina. The pneumonitis was compared with human farmer's lung, pneumonitis of housed cattle and other experimental hypersensitivity pneumonitides.  (+info)

Systemic infection with Alaria americana (Trematoda). (2/31967)

Alaria americana is a trematode, the adult of which is found in mammalian carnivores. The first case of disseminated human infection by the mesocercarial stage of this worm occurred in a 24-year-old man. The infection possibly was acquired by the eating of inadequately cooked frogs, which are intermediate hosts of the worm. The diagnosis was made during life by lung biopsy and confirmed at autopsy. The mesocercariae were present in the stomach wall, lymph nodes, liver, myocardium, pancreas and surrounding adipose tissue, spleen, kidney, lungs, brain and spinal cord. There was no host reaction to the parasites. Granulomas were present in the stomach wall, lymph nodes and liver, but the worms were not identified in them. Hypersensitivity vasculitis and a bleeding diathesis due to disseminated intravascular coagulation and a circulating anticoagulant caused his death 8 days after the onset of his illness.  (+info)

Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum. (3/31967)

Injections of killed suspensions of Corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. It is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions.  (+info)

Suppression of Moloney sarcoma virus immunity following sensitization with attenuated virus. (4/31967)

Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of normal adult BALB/c mice with attenuated MSV-M resulted in an altered pattern of tumor immunity. Injection of active MSV-M into the presensitized animals resulted in tumor induction and rejection similar to that observed in normal animals, but rejection failed to produce protection against the secondary inoculation with MSV-M. After the second inoculation with active MSV-M, tumors appeared and progressed but ultimately were rejected. Over 80% of the mice died, 25% after the primary challenge and the remainder after the secondary challenge. At death, all mice had histological evidence of leukemia which was the probable cause of death. The animals that died following the secondary challenge also had evidence of disseminated MSV-M. Solid tumor nodules were found in skeletal muscle distant from the original site of inoculation, and active MSV-M was isolated from spleen and lungs. The possibility that the results were produced by specific suppression of MSV-Moloney leukemia virus immunity is discussed.  (+info)

Factors influencing the deposition of inhaled particles. (5/31967)

Because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue, respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols. Factors influencing the deposition of inhaled particles can be classified into three main areas: (1) the physics of aerosols, (2) the anatomy of the respiratory tract and (3) the airflow patterns in the lung airways. In the physics of aerosols, the forces acting on a particle and its physical and chemical properties, such as particle size or size distribution, density, shape, hygroscopic or hydrophobic character, and chemical reactions of the particle will affect the deposition. With respect to the anatomy of the respiratory tract, important parameters are the diameters, the lengths, and the branching angles of airway segments, which determine the deposition. Physiological factors include airflow and breathing patterns, which influence particle deposition. Various lung models used in predicting particle deposition are reviewed and discussed. The air-way structures of various animal species are compared, showing the unique structure of the human lung compared to the animal species under study. Regional deposition data in man and dog are reviewed. Recent deposition data for small rodents are presented, showing regional difference in deposition with the right apical lobe having the highest relative deposition.  (+info)

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. (6/31967)

BACKGROUND: Fully adapting a forward genetic approach to mammalian systems requires efficient methods to alter systematically gene products without prior knowledge of gene sequences, while allowing for the subsequent characterization of these alterations. Ideally, these methods would also allow function to be altered in a temporally controlled manner. RESULTS: We report the development of a miniaturized cell-based assay format that enables a genetic-like approach to understanding cellular pathways in mammalian systems using small molecules, rather than mutations, as the source of gene-product alterations. This whole-cell immunodetection assay can sensitively detect changes in specific cellular macromolecules in high-density arrays of mammalian cells. Furthermore, it is compatible with screening large numbers of small molecules in nanoliter to microliter culture volumes. We refer to this assay format as a 'cytoblot', and demonstrate the use of cytoblotting to monitor biosynthetic processes such as DNA synthesis, and post-translational processes such as acetylation and phosphorylation. Finally, we demonstrate the applicability of these assays to natural-product screening through the identification of marine sponge extracts exhibiting genotype-specific inhibition of 5-bromodeoxyuridine incorporation and suppression of the anti-proliferative effect of rapamycin. CONCLUSIONS: We show that cytoblots can be used for high-throughput screening of small molecules in cell-based assays. Together with small-molecule libraries, the cytoblot assay can be used to perform chemical genetic screens analogous to those used in classical genetics and thus should be applicable to understanding a wide variety of cellular processes, especially those involving post-transitional modifications.  (+info)

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (7/31967)

We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pulmonary inflammation using mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-). Wild-type (Wt) and IL-8r-/- mice were systemically immunized to ovalbumin (OVA) and were exposed with either single or multiple challenge of aerosolized phosphate-buffered saline (OVA/PBS) or OVA (OVA/OVA). Analysis of cells recovered from bronchoalveolar lavage (BAL) revealed a diminished recruitment of neutrophils to the airway lumen after single challenge in IL-8r-/- mice compared with Wt mice, whereas multiply challenged IL-8r-/- mice had increased B cells and fewer neutrophils compared with Wt mice. Both Wt and IL-8r-/- OVA/OVA mice recruited similar numbers of eosinophils to the BAL fluid and exhibited comparable degrees of pulmonary inflammation histologically. Both total and OVA-specific IgE levels were greater in multiply challenged IL-8r-/- OVA/OVA mice than in Wt mice. Both the IL-8r-/- OVA/OVA and OVA/PBS mice were significantly less responsive to methacholine than their respective Wt groups, but both Wt and IL-8r mice showed similar degrees of enhancement after multiple allergen challenge. The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen.  (+info)

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. (8/31967)

The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia. To test whether these water channels facilitate fluid movement between airspace, interstitial, and capillary compartments, we measured passive and active fluid transport in AQP1 and AQP4 knockout mice. Airspace-capillary osmotic water permeability (Pf) was measured in isolated perfused lungs by a pleural surface fluorescence method. Pf was remarkably reduced in AQP1 (-/-) mice (measured in cm/s x 0.001, SE, n = 5-10: 17 +/- 2 [+/+]; 6.6 +/- 0.6 AQP1 [+/-]; 1.7 +/- 0.3 AQP1 [-/-]; 12 +/- 1 AQP4 [-/-]). Microvascular endothelial water permeability, measured by a related pleural surface fluorescence method in which the airspace was filled with inert perfluorocarbon, was reduced more than 10-fold in AQP1 (-/-) vs. (+/+) mice. Hydrostatically induced lung interstitial and alveolar edema was measured by a gravimetric method and by direct measurement of extravascular lung water. Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes. Active, near-isosmolar alveolar fluid absorption (Jv) was measured in in situ perfused lungs using 125I-albumin as an airspace fluid volume marker. Jv (measured in percent fluid uptake at 30 min, n = 5) in (+/+) mice was 6.0 +/- 0.6 (37 degrees C), increased to 16 +/- 1 by beta-agonists, and inhibited to less than 2.0 by amiloride, ouabain, or cooling to 23 degrees C. Jv (with isoproterenol) was not affected by aquaporin deletion (18.9 +/- 2.2 [+/+]; 16.4 +/- 1.5 AQP1 [-/-]; 16.3 +/- 1.7 AQP4 [-/-]). These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport. AQP1 facilitates hydrostatically driven lung edema but is not required for active near-isosmolar absorption of alveolar fluid.  (+info)

In order to make this discovery, they conducted the experiment in three steps. First, they injected the lung protein alone inside frog eggs to measure its function. Second, they injected both the M2 protein from H1N1 virus and the lung protein inside frog eggs and found that the H1N1 virus M2 protein caused the lung protein function to decrease significantly. By means of molecular biology techniques, scientists isolated the segment of the H1N1 virus M2 protein responsible for the damage to the lung protein and were able to demonstrate that without this segment, the H1N1 virus was unable to damage the lung protein. Third, an intact, full H1N1 virus M2 protein and the lung protein were then re-injected into frog eggs along with antioxidant drugs. This also prevented H1N1 virus M2 protein from damaging the lung protein. When these experiments were repeated using human lung cells, the results were exactly the same ...
TY - JOUR. T1 - Steroid metabolism by the lung. T2 - Conversion of dihydrotestosterone to 5α-androstan-3α, 17β-diol by rat lung tissue in vitro. AU - Kao, Lidia Wei Liu. AU - Crosswell, M. Jane. AU - Weisz, Judith. PY - 1979/3. Y1 - 1979/3. N2 - The potential of lung tissue of adult male rats to metabolize dihydrotestosterone (DHT) in vitro was examined. Within 3 min, a homogenate of 100 mg lung tissue, cleared of blood by perfusion before homogenization, metabolized 90% of the [3H]DHT substrate. Approximately 80% of the DHT was converted to 5α-androstan-3α, 17β-diol. The amount of 5α-androstan- 3α, 17β-diol formed during a 5-min incubation increased linearly, with substrate concentrations ranging from 3.3 × 10-8 to 3 × 10-6 M. Thus, the capacity of rat lung tissue to metabolize DHT in vitro and the rate of 3α-reduction of DHT are sufficiently great to consider the possibility that lung may be responsible for the rapid clearance of DHT from the circulation in this species.. AB - The ...
TY - JOUR. T1 - IL-33 mediates inflammatory responses in human lung tissue cells. AU - Yagami, Akiko. AU - Orihara, Kanami. AU - Morita, Hideaki. AU - Futamura, Kyoko. AU - Hashimoto, Noriko. AU - Matsumoto, Kenji. AU - Saito, Hirohisa. AU - Matsuda, Akio. PY - 2010/11/15. Y1 - 2010/11/15. N2 - IL-33 is a member of the IL-1 family and mediates its biological effects via the ST2 receptor, which is selectively expressed on Th2 cells and mast cells. Although polymorphic variation in ST2 is strongly associated with asthma, it is currently unclear whether IL-33 acts directly on lung tissue cells at sites of airway remodeling. Therefore, we aimed to identify the IL-33-responsive cells among primary human lung tissue cells. ST2 mRNA was expressed in both endothelial and epithelial cells but not in fibroblasts or smooth muscle cells. Correspondingly, IL-33 promoted IL-8 production by both endothelial and epithelial cells but not by fibroblasts or smooth muscle cells. Transfection of ST2 small ...
In recent years, significant progress has been made in dissecting the genetic control of mammalian lung development. Many transcription factors, peptide growth factors and their receptors, as well as extracellular matrix components have been identified as important regulators of lung morphogenesis in reverse genetics approaches (Warburton et al. 2000; Groenman et al. 2004; Kumar and Ryan 2004). Chemical mutagenesis using the potent germline mutagen ENU represents a powerful means to complement these gene-driven approaches by phenotype-based screens in mice (De Angelis et al. 2000; Nolan et al. 2000; Kile et al. 2003). This report describes the positional cloning of the perinatal lethal, ENU-induced l7Rn64234SB allele and identifies a pivotal role for the previously hypothetical gene NM_026304 in Clara cell function during mouse lung development. The ENU-induced nonsense mutation truncated the carboxy-terminal 17 aa, rendering the l7Rn64234SB protein unstable. However, detection of residual ...
TY - JOUR. T1 - Low-dose of ionizing radiation enhances cell proliferation via transient ERK1/2 and p38 activation in normal human lung fibroblasts. AU - Kim, Cha Soon. AU - Kim, Jin Mo. AU - Nam, Seon Young. AU - Yang, Kwang Hee. AU - Jeong, Meeseon. AU - Kim, Hee Sun. AU - Lim, Young Khi. AU - Kim, Chong Soon. AU - Jin, Young Woo. AU - Kim, Joon. PY - 2007/9/27. Y1 - 2007/9/27. N2 - This study shows the human cellular responses and the mechanism of low-dose ionizing radiation in CCD 18 Lu cells, which are derived from normal human lung fibroblasts. Cell proliferation and viability assay were measured for the cells following γ-irradiation using trypan blue, BrdU incorporation, and Wst-1 assay. We also examined genotoxicity using a micronuclei formation assay. The activation of the MAPKs pathway was determined by Western blot analysis, and the siRNA system was used to inhibit the expression of ERK1/2 and p38. We found that 0.05 Gy of ionizing radiation stimulated cell proliferation and did not ...
Human, Mouse, Rat - Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1003 Human, Mouse, Rat - Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1003
Image: by Phil Schatz License: CC BY 4.0. Basically, a distinction is made between right and left lung. The left lung consists of two cloth (Lobi superior and inferior pulmonis sinistri), which are separated from each other by the fissura obliqua. The right lung, in turn, consists of three lobes (lobi superior, medius and inferior pulmonis dextri). The subdivision is done by the Fissura obliqua and the Fisura horizontalis pulmonis dextri. These fissures extend deep into the lung tissue and are, like the surface of the lung, lined with the visceral pleura.. The further structure is identical in both lungs. One distinguishes between the lung tip (Apex pulmonis), the lung base (Base pulmonis), the lung surfaces and the lung margins. The lung surface is covered by a serous skin, the visceral pleura, and appears pale pink in the healthy to gray. Depending on the position and the relationship to the thorax one differentiates with the lung surfaces (Facies pulmonis) between the facies costalis, ...
TY - JOUR. T1 - Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. AU - Kalinichenko, Vladimir V.. AU - Gusarova, Galina A.. AU - Kim, Il-man. AU - Shin, Brian. AU - Yoder, Helena M.. AU - Clark, Jean. AU - Sapozhnikov, Alexander M.. AU - Whitsett, Jeffrey A.. AU - Costa, Robert H.. PY - 2004/3/1. Y1 - 2004/3/1. N2 - The forkhead box (Fox) f1 transcription factor is expressed in the mouse splanchnic (visceral) mesoderm, which contributes to development of the liver, gallbladder, lung, and intestinal tract. Pulmonary hemorrhage and peripheral microvascular defects were found in approximately half of the newborn Foxf1(+/-) mice, which expressed low levels of lung Foxf1 mRNA [low-Foxf1(+/-) mice]. Microvascular development was normal in the surviving newborn high-Foxf1(+/-) mice, which compensated for pulmonary Foxf1 haploinsufficiency and expressed wild-type Foxf1 levels. To identify expression of genes regulated by Foxf1, we used Affymetrix microarrays to determine ...
Matched Pair (Normal and Carcinoma) Human Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1002 Matched Pair (Normal and Carcinoma) Human Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1002
The development of lungs and the process that enables respiration is still not well understood at the molecular level. To fill the knowledge gaps, PNNL scientists are systematically characterizing normal lung development in mice and humans.
We are working with NHS Liverpool Clinical Commissioning Group to offer lung health checks to people at the Practice. This programme is known as the Liverpool Healthy Lung Programme. You can find out more about it online here: http://bit.ly/LiverpoolHealthyLungs Here you can also watch an inspiring video about Dennis, who recently attended a clinic. The clinics are offered to people aged 55-75 who have ever smoked or who have COPD (Chronic Obstructive Pulmonary Disease). If you are in this group you should receive a clinic invite letter in April, after which you should book an appointment as soon as possible. At your appointment you will see a specialist lung nurse who will ask about your general health and also some questions about your lungs and breathing. S/he may also check your breathing using Spirometry (a tube you blow in). With your permission s/he will also offer to assess your risk of lung cancer using a Lung Risk Score. If you decide to have the Lung Risk Score, you may be offered a ...
While the adult murine lung utilizes multiple restricted progenitor cells during homeostasis and fix compartmentally, very much less is known about the progenitor cells from the human lung. fix utilizing murine versions have got provided essential ideas into both lung regeneration and homeostasis. These research have got proven that the adult mouse lung epithelium can be fairly quiescent and will not really adhere to the traditional control cell model [1]. Rather, the lung shows up to conform to a maintenance structure identical to that of various other tissue with gradual turnover prices, such as the pancreas [2], [3]. During regular tissues homeostasis, abundant facultative progenitor cells located throughout the lung epithelium mediate any 1420477-60-6 manufacture required maintenance. These facultative progenitor cells, Clara cells and Type II pneumocytes, are quiescent and function as differentiated cells of the mature lung epithelium, but keep the capability to differentiate and self-renew ...
Bronchopulmonary dysplasia (BPD) remains a major respiratory illness in extremely premature infants. The biological mechanisms leading to BPD are not fully understood, although an arrest in lung development has been implicated. The current study aimed to investigate the occurrence of autophagy in the developing mouse lung and its regulatory role in airway branching and terminal sacculi formation. We found 2 windows of epithelial autophagy activation in the developing mouse lung, both resulting from AMPK activation. Inhibition of AMPK-mediated autophagy led to reduced lung branching in vitro. Conditional deletion of beclin 1 (Becn1) in mouse lung epithelial cells (Becn1Epi-KO), either at early (E10.5) or late (E16.5) gestation, resulted in lethal respiratory distress at birth or shortly after. E10.5 Becn1Epi-KO lungs displayed reduced airway branching and sacculi formation accompanied by impaired vascularization, excessive epithelial cell death, reduced mesenchymal thinning of the interstitial ...
Bronchopulmonary dysplasia (BPD) remains a major respiratory illness in extremely premature infants. The biological mechanisms leading to BPD are not fully understood, although an arrest in lung development has been implicated. The current study aimed to investigate the occurrence of autophagy in the developing mouse lung and its regulatory role in airway branching and terminal sacculi formation. We found 2 windows of epithelial autophagy activation in the developing mouse lung, both resulting from AMPK activation. Inhibition of AMPK-mediated autophagy led to reduced lung branching in vitro. Conditional deletion of beclin 1 (Becn1) in mouse lung epithelial cells (Becn1Epi-KO), either at early (E10.5) or late (E16.5) gestation, resulted in lethal respiratory distress at birth or shortly after. E10.5 Becn1Epi-KO lungs displayed reduced airway branching and sacculi formation accompanied by impaired vascularization, excessive epithelial cell death, reduced mesenchymal thinning of the interstitial ...
Carlon, Marianne ; Toelen, Jaan ; Himmelreich, Uwe ; Debyser, Zeger ; Deprest, Jan. Combined non-invasive bioluminiscence and magnetic resonance imaging improves detection after pulmonary gene transfer in a fetal mouse model.30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine (Chicago(Il), Feb 01-06, 2010). In: American Journal of Obstetrics and Gynecology, Vol. 201, no. 6, p. S261 (2009 ...
For normal lifelong lung function, the prerequisites are: (1) normal lung function at birth; (2) normal growth in lung function until the adult plateau at 20-25 years of age; and (3) no accelerated deterioration from the plateau. Cohort studies have established that lung function either tracks or deteriorates, but never improves, after the preschool years.26-28 Thus, lung function in adult life is critically dependent on in utero and post-natal lung development.. An important antenatal factor affecting newborn lung function is maternal smoking, which causes structural effects on the developing lung.29 A study in more than 13 000 people showed that childhood disadvantage defined by either maternal or paternal asthma, childhood asthma, maternal smoking and childhood respiratory infections predicts worse adult lung function, a faster rate of lung function decline, and a greater prevalence of COPD.30 Other important influences include maternal antibiotic31 and paracetamol32 use, maternal ...
Biology Assignment Help, Mammalian lungs - respiration, Mammalian Lungs - Respiration In this we will study mainly mammalian lungs as it is the best representative of a respiratory surface adapted for terrestrial respiration. For this purpose, human lung can be taken as a model as shown in Figure. Wh
Optimal lung health from embryo through adulthood requires the complex interaction of pulmonary airspaces, interstitial and vasculature, beginning with organ development and culminating in programmed senescence. Technological advances have fostered a growing appreciation for the impact of cellular plasticity and the importance of cellular niche both during development and in response to both injury and repair. In addition to expanding the role of reactivation of developmental pathways lung repair, recent discoveries have demonstrated unique aging programs that will provide novel treatment strategies for chronic lung disease. The 5th Gordon Research Conference on Lung Development, Injury and Repair in August of 2019 seeks to attract cutting edge science to drive forward the field of lung development, injury, and repair toward the goal of facilitating novel therapeutic approaches to maximize lung health across the lifespan. This conference will strive to highlight new concepts behind the interactions
The lung is the main organ in the respiratory system and doesnt develop till about week 4 in the embryo. This stage of development is known as the Embryonic stage that covers the period of week 4-5 of the developing embryo. In this stage the 2 lung buds would have formed and lung lobes and the bronchopulmonary segments. The stem diverticulum will have differentiated into trachea and larynx. The Pseudoglandular stage is the period from 6 weeks to 16 weeks in the growing fetus. The events that occur in this stage include the formation of extensive airway branching of about 14 or more generations of branching resulting in terminal bronchioles. The conducting epithelium tubes are formed and are surrounded by thick mesenchyme. At 2 months all of the segmental bronchi would have formed. The distal structures at this stage are lined with cuboidal epithelium. The next stage is the Canalicular stage, from the period of week 16 to 25. The terminal bronchioles divide into two or more respiratory ...
If you are not aware of the lung problems then see here. There is a healthy lung month that will aware you about the various lungs problems.
Research in the Cardoso lab focuses on the mechanisms that regulate lung progenitor cell fate during lung development and on the contribution of developmental mechanisms to disease pathogenesis and regeneration-repair of the adult lung. We are investigating how progenitor cells generate the wide diversity of cell types of the mature respiratory system. In this context, we have been identifying early markers of cell fate and characterizing the genetic programs associated with acquisition of the various airway epithelial cell phenotypes as the lung forms. These studies have provided insights into the role of specific pathways, including retinoids, Fgf, Tgf beta and Notch in controlling the specification and expansion of lung progenitors, airway branching and differentiation of the various lung epithelial cell lineages. Over these years Our studies continue to explore the basic mechanisms of lung development, using this knowledge to understand the role of stem/progenitor cells in lung ...
The COVID-19 pandemic and its impact on respiratory system has highlighted the exigent needs to research pulmonary mechanics. This mini-symposium aims to showcase some recent studies using mathematical models to examine lung development, normal lung function, diseased lung conditions and functional deterioration. These research explorations provide insights to diseases such as asthma, tuberculosis, cystic fibrosis and treatment of lung infection. They have also advanced pulmonary tissue characterization and understanding of age related alterations in lung function. Lung diseases often leads to reduced lung function and poor quality of life and mathematical models can provide excellent avenues to unravel the complex dynamics that orchestrate lung decline in various health conditions. The models employed in these works cut across different areas of mathematical and computational mathematics, including reaction-diffusion models, partial differential equation models, agent-based models, image-based analyses
Epithelia from lung rudiments in which secondary bronchial buds are already established (14th and 13th gestational day for rat and mouse respectively) are able to undergo branching morphogenesis and cytodifferentiation in submandibular mesenchyme in vitro, whereas lung epithelium from one day younger foetuses rarely gives a morphogenetic response to submandibular mesenchyme and usually differentiates into primary (non-budding) bronchial epithelium.. The failure of 13-day rat lung epithelium to respond to submandibular mesenchyme can be prevented by peeling off the submandibular mesenchyme from the lung epithelium after 2½ days culture and replacing the same mesenchyme, or renewing it with fresh salivary mesenchyme ex vivo. Changes in the epithelial contour are visible by 10 h and buds form within 24 h; this is followed by branching morphogenesis in more than 66% of the samples.. The number of cells in S-phase in the epithelium is doubled within 3 to 5 h after the operation and the number of ...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
Lung cancer is a malignant tumour in the tissue of one or both lungs. A tumour may be found in the bronchi or in the spongy lung tissue. A tumour that starts in the lung is known as a primary lung cancer. Tumours in the lung may also be due to cancer which has spread through the blood from another part of the body such as the breast, bowel, or prostate - these cancers are called lung secondary or metastases. The following information refers to primary lung cancer.. Like other cancers, lung cancer is the result of the uncontrolled growth and multiplication of cells in the lung(s). Over time, this abnormal cell growth develops into a progressively larger mass which starts to invade functional parts of the lung, affecting breathing, causing pain and symptoms related to the loss of normal lung function. Doctors call this abnormal cluster of cells a tumour. These abnormal cells grow and divide uncontrollably and, if left untreated, eventually spread throughout the body.. ...
Aim: Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor 9 (TLR-9) in mice.. Materials and Methods: In this study, healthy male Swiss albino mice (n=30) aging 8-10 weeks were used to evaluate TLR-9 expression in lungs of mice following indoxacarb exposure with and without lipopolysaccharide (LPS). Indoxacarb was administered orally dissolved in groundnut oil at 4 and 2 mg/kg/day for 90 days. On day 91, five animals from each group were challenged with LPS/normal saline solution at 80 μg/animal. The lung tissues were processed for real time and immunohistochemical studies.. Results: LPS resulted increase in fold change m-RNA expression level of TLR-9 as compare to control, while indoxacarb (4 mg/kg) alone and in combination with LPS resulted 16.21-fold change and 29.4-fold change increase in expression of TLR-9 m-RNA, respectively, as compared to control. Similarly, indoxacarb (2 mg/kg) alone or in combination with LPS also altered TLR-9 expression. Further at protein ...
Fall is almost upon us and the weather is changing! This cold, dry season is often accompanied by a variety of symptoms, such as coughing, breathing difficulty, and other lung ailments. Additionally, by midlife, many people have compromised their lung health by smoking or by breathing urban air with its bounty of toxic pollutants. Studies show that lifespan is directly proportional to lung capacity. If our lungs arent working optimally to supply the body with oxygen, all the metabolic processes go haywire. Follow these tips to increase your lung health, expand your longevity, and quit coughing this fall.. Breathe Deeper For A Longer Life A larger lung capacity is related to a longer life, so it is important to work on your breathing. An effective way to increase your lung capacity is to play a wind instrument-a saxophone, trumpet, flute, or even a recorder. Practicing for as little as 10 or 15 minutes a day will give you expanded results for your lungs!. Antioxidants For Better Breathing ...
When lung cells are injured, there seems to be a cross talk between the damaged cells, the lung endothelial cells and the stem cells, explains Lee.. Lee and Kim are still trying to eavesdrop on this cross-talk, but one key factor produced by endothelial cells is a protein called thrombospondin (TSP-1). By adding it to 3-D cultures exposed to the air, mimicking the lung environment, Kim and Lee were able to prod even a single lung stem cell to start churning out alveolar cells. And by simply taking the TSP-1-rich liquid surrounding cultured endothelial cells and injecting it into the mice, they were able to reverse the lung damage caused by pulmonary fibrosis.. Conversely, when the researchers engineered lung endothelial cells to lack TSP-1 and added them to the 3-D cultures, the stem cells went down a different pathway, producing more airway cells. And in live mice unable to make TSP-1, airway repair was enhanced after injury.. TSP-1 is clearly a potential target for manipulation in patients ...
Illustration of Human lungs. Respiratory system. Healthy lungs. Light in the form of a tree. Line art. Drawing by hand. Medicine. vector art, clipart and stock vectors. Image 90830878.
With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance, says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Childrens Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. A key finding is that even after the resolution of infection, influenza results in lung parenchymal remodeling that may be critical to susceptibility to further injury, says Dr. Alcorn. This series of experiments used 6- to 8-week-old wild-type (WT) mice (C57BL/6 strain) as well as IL-22-deficient mice, infected with influenza A PR/8/34 H1N1 or control vehicle. To determine the distribution of IL-22 in the lung, they used ...
You know that smoking is bad for your lungs, but what does that mean? Heres what you need to know about the smokers lung vs. healthy lung discussion.
Stress is defined as the force applied to a material, while strain is the consequent deformation. In the whole lung, stress can be roughly approximated by the transpulmonary pressure, whereas the approximation of the average strain is the change in volume relative to the lung resting volume. The same tidal volume per kilogram may result in completely different strain according to the size of the baby lung (the V0 of the previous equation). For example, a 70-kg man with ARDS may have, according to the severity of the lung injury, a residual baby lung equal to 60%, 40%, or 20% of his normal lung size. If the ventilator is set to deliver 10 mL/kg, the actual delivered tidal volume would generate an alveolar strain, which would result from the application, in normal lung, of a tidal volume equal to 17 mL/kg, 25 mL/kg, and 50 mL/kg, values associated with a significant lung injury in laboratory studies. Recently we attempted to quantify the relationship between stress-strain and VILI in healthy ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) PAR-12-259. NIDDK
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) PAR-12-260. NIDDK
Work in the Robert H. Brown Lab explores several topics within pulmonary physiology, with a long-term goal of understanding the structural changes in the lungs that lead to the pathophysiology of lung disease. Our core studies examine the structure-function relationship of pulmonary airways and vessels as well as their role in chronic obstructive pulmonary disease (COPD) and reactive airway disease. Recent research has involved studying the mechanisms and treatment of COPD progression, new methods for treating asthma, and lung inflation and airway hyperresponsiveness. We are also exploring the impact of HIV infection on the etiology of lung disease and the pathophysiologic consequences of lung distention.. Research Areas: asthma, HIV, pulmonary physiology, lung disease, COPD, reactive airway disease ...
The NF-kappaB pathway has been shown to play a critical role in both adaptive and innate immunity and has been implicated as a focal point for induction of lung inflammation by a variety of inflammatory stimuli; however, the role of NF-kappaB in specific lung cell types remains unclear. We hypothesized that individual cell types in the lungs make important and unique contributions to the NF-kappaB dependent innate immune response. To determine the temporal and cell specific activation of NF-kappaB in vivo, an NF-kappaB reporter mouse in which expression of an enhanced green fluorescent protein (eGFP)/luciferase fusion protein cDNA driven by an NF-kappaB inducible promoter (NGL mouse) was generated. NF-kappaB activity was detected in intact, anesthetized animals by bioluminescence imaging and at the cellular level by detection of GFP on lung tissue sections. Using Eschericia coli lipopolysaccharide (LPS) and Pseudomonas aeruginosa models of lung inflammation, the timing and duration of NF-kappaB ...
To understand lung cancer, we must first understand the lungs. The lungs are two sponge-like organs in the chest. The right lung has three sections, called lobes. The left lung has two lobes. It is smaller because the heart takes up more room on that side of the body. The lungs bring air in and out, taking in oxygen and getting rid of carbon dioxide gas, which is a waste product of the body.. The lining which surrounds the lungs is called the pleura. The pleura protects the lungs. The windpipe, or trachea, brings air down into the lungs, and divides into tubes called bronchi, which divide into smaller branches called bronchioles. At the end of these small branches are tiny air sacs known as alveoli.. Most lung cancers start in the lining of the bronchi. But lung cancer can also begin in other areas such as the trachea, bronchioles, or alveoli. Lung cancer usually takes many years to develop.. ...
Patients who survive an acute lung injury are able to recover their lung function, suggesting that adult lungs regenerate to a certain extent. Depending on the cause and severity of the injury, multiple progenitor cells, including alveolar type II cells and distal airway stem cells, have been shown to drive lung tissue regeneration in mice. Now, Vaughan et al. describe another cell type involved in the repair process in mouse models lung damage from influenza virus infection or bleomycin inhalation: the rare lineage-negative epithelial progenitor (LNEP).. LNEP cells are quiescently present within normal distal mouse lung and do not express mature lineage markers, such as club cell 10 (CC10) protein and surfactant protein C (SPC). However, the authors demonstrate that these cells are activated to proliferate and migrate to damaged sites and mediate lung remodeling following major injury. Using lineage tracing approaches and cell transplantation, Vaughan et al. showed that LNEP cells, but not ...
Dendritic cells (DCs) residing in the lung are known to acquire inhaled Ag and, after migration to the draining bronchial lymph node (brLN), to present it to naive T cells in an either tolerogenic or immunogenic context. To visualize endogenous lung-derived DCs, we applied fluorescent latex beads (LXs) intratracheally, thereby in vivo labeling the majority of phagocytic cells within the lung. Of note, LX-bearing cells subsequently arriving in the draining brLN were found to represent lung-derived migratory DCs. Imaging explanted brLN by two-photon laser-scanning microscopy, we quantitatively analyzed the migration and interaction behavior of naive CD4+ T cells and endogenous, lung-derived DC presenting airway-delivered Ag under inflammatory or noninflammatory conditions. Ag-specific naive CD4+ T cells engaged in stable as well as transient contacts with LX-bearing DCs in both situations and displayed similar overall motility kinetics, including a pronounced decrease in motility at 16-20 h after ...
The use of the porcine lung to demonstrate recruitment maneuvers stimulated us to consider the possibility of using the ASL 5000 to investigate ways to improve protocols for the handling of ex-vivo perfused lungs. We believe this would provide interesting research projects for students and faculty. Many of the current ex-vivo perfusion protocols involve using positive pressure and high concentrations of oxygen to maintain isolated perfused lungs. The longest time that perfused lungs have been kept viable ex-vivo is about 10 hours. Using the ASL 5000 to model breathing, we would like to explore the possibility of extending survival time of ex-vivo perfused lungs. We believe that lowering the FiO2 and avoiding positive pressure ventilation could improve viability. Further development of this model could lead to advances in therapeutics related to airway clearance, mechanical ventilation, and airway pharmacology.. In the video below, the porcine lungs are attached to an Avea ventilator in the CPAP ...
Through the use of developmental and knock out studies Mig-6 has been shown to have a role in development. It has also been shown to be a tumour suppressor gene. Little work has been done as yet looking at its role in the adult. This study examined the role of Mig-6 in the lung with the ultimate goal being to determine if the pulmonary phenotype due to Mig-6 ablation is due to a developmental programming or loss of function in the adult. This was investigated in two ways. 1. To investigate if knocking out Mig-6 in adult lung has an effect on lung function2. Investigate the role of Mig-6 in lung epithelial cells by RNAi (Investigation of the Role of Mig-6 in Pulmonary Epithelial Cells and Vascular Cells In Vitro).Knocking out Mig-6 in the adult mice showed no difference in epithelial markers and after staining morphology and airway size were found to be normal. This would seem to indicate that the Mig-6 phenotype is due to altered development of the lungs during the neonatal period and not due to a loss
We have read with interest the article by Taylor et al. concerning the mechanism of lung development in the etiology of congenital malformations of the pulmonary airways in adults. The authors discussed the etiology of congenital malformations of the pulmonary airways, suggesting a partial modification of lung development with a potential risk of malignancy.. Although we generally agree with their assessment, there are some weaknesses in their work that we would like to highlight as well as some points on which we would like to propose an alternative point of view. Different transcription factors known to be involved in lung development have already been studied in CPAM. Two of them, SOX2 and SOX9 are described as important in the spatiotemporal branching development since the pseudoglandular stage [1, 2]. In CPAM, SOX2 is present in both CPAM types (1 and 2), but their expression differs between them [3]. In addition, previously published papers have shown persistent SOX2 expression in ...
Goal of the present study is to investigate the specific cellular responses to nCeO2 and nFe2O3 in various lung cell types and develop an in vitro chronic exposure model to predict the potential fibrogenic and carcinogenic effects. Primary human lung fibroblasts were treated with nCeO2 (size dXRD = 17 nm, SSA = 61 m2/g) and direct stimulation of collagen production (a hallmark of fibrosis) was evaluated. In separate experiments, primary human small airway epithelial cells were exposed to a sub-lethal concentration (0.625 µg/cm2) of nCeO2 and nFe2O3 (size dXRD = 20 nm, SSA = 50 m2/g) for 6 weeks and their effects on cell transformation and invasion were evaluated. Our results showed new data that nCeO2 can induce a dose-dependent increase in collagen production by lung fibroblasts; nCeO2 can induce proliferation of lung epithelial cells as compared to vehicle-treated control and nFe2O3 induced neoplastic transformation of epithelial cells as determined by soft-agar colony formation assay and transwell
Intestinal bacteria transferred at birth affect lung development, bacterial resistance and susceptibility to inflammatory conditions in newborns, according to a new mouse study.
Lung development is a highly orchestrated process characterized by timed expression and activation of growth factor and protease/antiprotease systems. This interplay is essential in regulating vasculogenesis, alveolarization, and epithelial to mesenchymal transition during lung development. Alterati …
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YALE (US)-Scientists have achieved an important first step in regenerating fully functional lung tissue that can exchange gas-the key role of the lungs.. Details appear in the June 24 issue of Science Express.. Lung disease accounts for around 400,000 deaths each year in the United States. Lung tissue is difficult to regenerate because it does not generally repair or regenerate beyond the microscopic level.. The only current way to replace damaged adult lung tissue is to perform lung transplantation, which is highly susceptible to organ rejection and infection and achieves only 10 percent to 20 percent survival at 10 years.. The researchers goal was to see if it was possible to successfully implant tissue-engineered lungs, cultured in vitro, that could serve the lungs primary function of exchanging oxygen and carbon dioxide.. They took adult rat lungs and first removed their existing cellular components, preserving the extracellular matrix and hierarchical branching structures of the airways ...
The Lung Scan provides a detailed visualization of the lungs. The Advanced Lung Analysis software allows highly accurate volume measurement of lung nodules. With its 3D volume measurement, we are better able to determine changes in nodule volume and to quantify growth rate and doubling time for lesions, allowing earlier and more accurate identification of small lung cancers. This enables our radiologists to detect lung cancer at its earliest stage, usually undetectable by an ordinary chest x-ray.. The Lung Scan can also detect other lung damage such as emphysema from smoking or lung scarring from prior infection. ...
Caveolin-1 is a key regulator of pulmonary endothelial barrier function. interleukin-6, and promoted BAL neutrophilia in WT mice. Lung injury by these criteria was significantly reduced in Cav-1-/- mice but fully restored by i.v. injection of liposome/Cav-1 cDNA complexes that rescued expression of Cav-1 in lung microvessels. As thrombin is known to play a significant role in mediating stretch-induced vascular injury, we observed in cultured mouse lung microvascular endothelial cells (MLECs) thrombin-induced albumin hyperpermeability and phosphorylation of p44/42 MAP kinase in WT but not in Cav-1-/- MLECs. Thus, caveolin-1 expression is required for mechanical stretch-induced lung inflammation and endothelial hyperpermeability in vitro and in vivo. was measured in isolated lung preparations explanted from mice after two hours of injurious or control ventilation. The procedure is usually described in detail by Gorovoy in WT and Cav-1-/- mice (Fig. 2). For 125I-BSA determination, mice were ...
Small airways are abnormal in asthma [1]. One measurement of small airway function is Sacin, derived from the multiple-breath nitrogen washout (MBNW) test. Sacin reflects ventilation heterogeneity in diffusion-dependent airways, and is correlated with airway hyperresponsiveness [2] and asthma control [3]. Theoretically, heterogeneity of diffusion-dependent ventilation can arise due to the heterogeneity of cross-sectional areas of airway openings in terminal airways and the acini [4]. Therefore, Sacin may be affected by structural changes in those airways. The elastic properties of the lung may also affect Sacin, as the phase III slope, a marker of ventilation heterogeneity derived from the single-breath nitrogen washout, correlates with lung compliance in explanted lungs of smokers and in healthy lungs [5]. ...
... axial lung window) Chest CT (coronal lung window) Chest CT (axial lung window) Chest CT (coronal lung window) "Meet the lungs" ... Humans have two lungs, a right lung and a left lung. They are situated within the thoracic cavity of the chest. The right lung ... Atelectasis Drowning Interstitial lung disease Liquid breathing Lung abscess Lung-on-a-chip Secarecytosis List of terms of lung ... These fixed size lungs are called "circulatory lungs", as distinct from the "bellows-type lungs" found in most other animals. ...
... or white lung syndrome may refer to: Acute respiratory distress syndrome Asbestosis Pulmonary alveolar ... a Canadian punk rock group This disambiguation page lists articles associated with the title White lung. If an internal link ...
VNexpress from Tuổi Trẻ: Lung leng: Mảnh đất của người tiền sử 24 July 2001 "Lung Leng: window to prehistoric time". SEAArch - ... Archaeologists have recovered over 14,000 stone, pottery and metal artifacts from Lung Leng. The excavation of Lung Leng is ... Lung Leng is an archaeological site located in Sa Binh commune, Sa Thầy District, Kon Tum Province of the Central Highlands ...
... at RomanianSoccer.ro (in Romanian) Daniel Lung at Soccerway v t e (Articles with Romanian-language sources (ro), ... Daniel Cristian Lung (born 3 Oct 1987) is a Romanian professional footballer who plays as a centre back for Metaloglobus ...
Permanent lung damage can arise due to one's inability to recognize the cause of symptoms. Farmer's lung occurs because ... After multiple exposures, it takes less and less of the antigens to set off the reaction in the lung. Farmer's lung disease ( ... examining lung tissue • performing an immunological investigation • performing a lung function test • reviewing the clinical ... Diagnoses of Farmer's lung is difficult due to its similarity to cold and flu-like symptoms. Doctors diagnose patients with ...
Lung begins life as a poor farmer and marries O-Lan, a slave owned by the Hwang family. Wang Lung maintains a fierce attachment ... Wang Lung is the protagonist of The Good Earth, a Pulitzer Prize-winning novel by Pearl S. Buck and the first volume of her ... Wang Lung arranges a marriage for the youngest daughter to the son of a prosperous grain merchant, in order to keep her safe ... Sparknotes: Wang Lung v t e (Articles with short description, Short description matches Wikidata, Short description is ...
... was an epidemic of lung disease resulting from domestic exposure to asbestos in the village of Metsovo in ... Metsovo lung: pleural calcifications and restrictive lung function in north-western Greece; environmental exposure to mineral ... Transbronchial lung biopsies from Metsovites with extensive PCs were then obtained and sent to Mount Sinai Hospital in New York ... Association of Metsovo lung and pleural mesothelioma with exposure to tremolite-containing whitewash. Lancet i, 1987; April 25 ...
It proved a success and soon[when?] superseded the iron lung throughout Europe.[citation needed] The iron lung now has a ... In 1931, John Haven Emerson (1906-1997) introduced an improved and less expensive iron lung. The Emerson iron lung had a bed ... "Power failure kills iron lung lady". The Sydney Morning Herald. May 29, 2008. Retrieved July 1, 2011. "60 years in an iron lung ... "Hess offers iron lung for COVID-19," April 9, 2020, Hays Daily News, retrieved April 11, 2020 "The Iron Lung," Science Museum ...
Lung commented, "I can't complain when every week I get to blow something up or build some insane machine. Every day, I check ... Lung attended the School of Visual Arts (SVA) in Manhattan, where he received his MFA in Products of Design in 2016. His MFA ... Lung spends time fabricating in his shop, as well as searching through junkyards, searching for parts to use. He also enjoys ... Jonathan Lung is originally from Brooklyn, New York. He moved to Heartland Village, Staten Island as a child. He graduated from ...
Static lung compliance is the change in volume for any given applied pressure. Dynamic lung compliance is the compliance of the ... Lung compliance, or pulmonary compliance, is a measure of the lung's ability to stretch and expand (distensibility of elastic ... The compliance of the lungs demonstrate lung hysteresis; that is, the compliance is different on inspiration and expiration for ... Low compliance indicates a stiff lung (one with high elastic recoil) and can be thought of as a thick balloon - this is the ...
Lung is most known for her documentary Finding Kukan, which focuses on the overlooked producer of Kukan, Li Ling A. Lung ... Lung was the associate producer for the 2008 documentary Patsy Mink: Ahead of the Majority. Lung was an additional producer on ... In 2016, Lung's documentary Finding Kukan. It was shown at DOCNYC, a documentary film festival in November 2016. It had been ... Lung attended the Chinese American Women in History Conference 2019 at the Chinese American Museum. It was announced on April 5 ...
... is a bimonthly peer-reviewed nursing journal covering research on the care of patients with cardiac and pulmonary ... "Heart & Lung". 2017 Journal Citation Reports. Web of Science (Science ed.). Clarivate Analytics. 2018. Official website v t e v ...
... , also known as lung carcinoma (since about 98-99% of all lung cancers are carcinomas), is a malignant lung tumor ... list on each side Stage IIIA lung cancer Stage IIIB lung cancer Stage IIIB lung cancer Stage IV lung cancer Treatment for lung ... Diagrams of main features of staging Stage IA and IB lung cancer Stage IIA lung cancer Stage IIB lung cancer One option for ... Around a third of people diagnosed with lung cancer have symptoms caused by metastases in sites distant from the lung. Lung ...
A lung cavity or pulmonary cavity is an abnormal, thick-walled, air-filled space within the lung. Cavities in the lung can be ... The presence of lung cavities is associated with worse outcomes in lung cancer and tuberculosis; however, if a lung cancer ... including lung cysts, emphysema, bullae, and cystic bronchiectasis. Lung cysts are the most common mimics of lung cavities. ... Diagnosis of a lung cavity is made with a chest X-ray or CT scan of the chest, which helps to exclude mimics like lung cysts, ...
Lung is a town and Village Development Committee in Pyuthan, a Middle Hills district of Rapti Zone, western Nepal. "Nepal ...
Lung was born in Idaho to George Lung and Lillian Pfeiffer. His parents divorced when he was young, and he grew up in Colorado ... Clarence Lung at IMDb Clarence Lung at Aveleyman The Blade Thursday, September 8, 1960 TV and Radio Program Guide, Tonight's TV ... Clarence Lung (1914-1993) was a film and television actor. He appeared in films such as Dragon Seed, Song of the Sarong, ... Lung's television credits include Guys Like O'Malley, a story about an observation post during the Korean war, in which he ...
Kong Lung at IMDb Patrick Lung at AllMovie Patrick Lung at the Hong Kong Movie DataBase Patrick Lung at filmaffinity.com Lung ... Patrick Lung (8 February 1934 - 2 September 2014), also known as Lung Kong, Patrick Lung Kong, was a film director from Hong ... 余, 瑋 (11 January 2014). "名導龍剛:邵是香港電影之父" [Famous Director Patrick Lung: Shaw is the Father of Hong Kong Film Industry]. Ming Pao ... 朱, 澤人 (2 September 2014). "導演鬼才龍剛,慈濟路上永遠的菩薩" [Director Genius Patrick Lung, the Eternal
Lung as a child, asked him to play a father in the film. Lung's sensitive portrayal of an elderly man faced with change turned ... Sihung Lung (Chinese: 郞雄; pinyin: Láng Xíong; Wade-Giles: Lang Hsiung; c. 1930 - May 2, 2002), also known as Paul Lung, was a ... "I learned so much from Ang Lee and this lovely actor Siung Lung. Or Paul Lung as I recall he liked being called". Archived from ... Sihung Lung at IMDb Sihung Lung at the Hong Kong Movie DataBase (Articles with short description, Short description is ...
Sarcomas of the lung. Some rare vascular tumors of the lung Non-lung tumors which may grow into the lungs: Mediastinal tumors ... Lung tumors are neoplastic lung nodules. These include: Primary tumors of the lung/pulmonary system: Bronchial leiomyoma, a ... Metastasis to the lung Lung nodule Horn L, Lovly CM (2018). "Chapter 74: Neoplasms of the lung". In Jameson JL, Fauci AS, ... of the lung Pulmonary carcinoid tumor Pleuropulmonary blastoma Neuroendocrine tumors of the lung Lymphomas of the lung. ...
... Wai-man (traditional Chinese: 龍緯汶; simplified Chinese: 龙纬文) is the chairman of the Southern Democratic Alliance, a ... In 2020, Lung pleaded guilty to seven offences and was sentenced to 32 months in prison. "2008 Legislative Council Election". ...
... (Chinese: 陳龍; pinyin: Chén Long; 1852 - August 11, 1889) was a Chinese businessman in the Hawaiian Kingdom. He ... He was also known as Alung or Ah Lung using the common Cantonese diminutive prefix Ah (阿) before his given name. Alung was born ... "The Late Chun Lung". The Pacific Commercial Advertiser. Honolulu. August 15, 1889. p. 3. Retrieved February 17, 2020. "The Late ... According to historian Bob Dole, "Yale University has Chun Lung's records, but I have yet to document that Toney went to ...
... may refer to: Longgang District, Shenzhen, a district in Guangdong, People's Republic of China Patrick Lung, a Hong ... Kong film director This disambiguation page lists articles associated with the title Lung Kong. If an internal link led you ...
Robertsonspianos.com gordonbellpianos.com Wendl & Lung History Wendl & Lung production "WENDL & LUNG". BestPricePiano. ... The Wendl & Lung brand started in 1910 as a collaboration between Stefan Lung and Johann Wendl in Vienna, Austria. From around ... Wendl & Lung Официальный сайт Wendl & Lung в России (CS1 German-language sources (de), Piano manufacturing companies of Austria ... Wendl & Lung is a piano-manufacturing company based in Vienna, widely regarded for their product. ...
... Beneath the Mulberry Tree (1940), Kai Lung: Six (1974) and Kai Lung Raises His Voice (2010). Kai Lung is a Chinese ... consisting of The Wallet of Kai Lung (1900), Kai Lung's Golden Hours (1922), Kai Lung Unrolls His Mat (1928), The Moon of Much ... which generally take up the majority of a Kai Lung book. Kai Lung is a man of very simple motivations; most frequently, he is ... Lamb relaxes while reading Kai Lung. Dorothy L. Sayers mentions him in several Lord Peter Wimsey novels: In chapter IV of ...
... Group, a listed company Hang Lung Properties, subsidiary of Hang Lung Group Hang Lung Bank, a defunct bank This ... Hang Lung may refer to the following Hong Kong companies: ... page lists articles associated with the title Hang Lung. If an ...
In Indonesia, Nasi kuning can be made with cow lung. Paru goreng is fried cow lung Padang food. It is a type of offal. Animal ... Cow lung is used in various cuisines and as a source for pulmonary surfactants. In Peru it is known as bofe. ... Defibrotide is a deoxyribonucleic acid derivative (single-stranded) derived from cow lung. (Articles lacking sources from April ... surfactants include Beractants Alveofact extracted from cow lung lavage fluid and Survanta extracted from minced cow lung with ...
Media related to Silviu Lung at Wikimedia Commons Silviu Lung at WorldFootball.net Silviu Lung at National-Football-Teams.com ( ... "Tibi Lung îşi înlocuieşte tatăl şi va fi antrenorul fratelui său la Craiova" [Tibi Lung replaced his father and his brother ... Silviu Lung at RomanianSoccer.ro (in Romanian) "Interviu-eveniment cu Silviu Lung: "Regret că nu m-am dus la Steaua în '86, ... Silviu Lung senior va fi antrenor principal după două decenii. "Îmi doream de mai mult timp şi îmi era şi dor să revin în ...
In the case of a singular lung transplant the lung is collapsed, the blood vessels in the lung tied off, and the lung removed ... Donor lungs can be retrieved from a living or deceased donor. A living donor can only donate one lung lobe. With some lung ... The donor lung is placed, the blood vessels and bronchial tube reattached, and the lung reinflated. To make sure the lung is ... With other lung diseases such as cystic fibrosis, it is imperative that a recipient receive two lungs. While lung transplants ...
... may refer to: Foreign body aspiration Pulmonary aspiration This disambiguation page lists articles associated ... with the title Lung aspiration. If an internal link led you here, you may wish to change the link to point directly to the ...
A resource for findings and recommendations to reduce the risk of severe obstructive lung disease (bronchiolitis obliterans) ... a serious lung disease that is irreversible. In this disease, the smallest airways in the lung (the bronchioles) become scarred ... Read "Coffee Workers at Risk for Lung Disease" and "Diacetyl and Food Flavorings" on the NIOSH Science Blog and share your ... Preventing Lung Disease in Workers Who Use or Make Flavorings. In addition to the full Alert in English, a Summary Sheet is ...
2022 American Lung Association. The American Lung Association is a 501(c)(3) charitable organization. Our Tax ID is: 13‑1632524 ... Breathing ozone irritates the lungs, resulting in something like a bad sunburn within the lungs. ... The Lung Association opposes these actions that will add pollution to the air we breathe. ... Breathing in particle pollution can increase the risk of lung cancer, according to the World Health Organization. ...
Learn about recent advances in treatment and management of lung transplant recipients. ... Lung Transplant-Specific Absolute Contraindications *. Age - ,65 for single-lung, ,55 for bilateral lung, ,45 for heart-lung ... Table 5. Table 5. Diseases Treatable By Single, Bilateral Sequential, and Heart-Lung Transplantation Single Lung ... the Toronto Lung Transplant Group was also the first to report success with en bloc double-lung transplantation in humans.[11] ...
... : Proportionate mortality ratio (PMR) adjusted for age, sex, and race by usual industry, U.S. residents age 15 and ... Lung cancer: Proportionate mortality ratio (PMR) adjusted for age, sex, and race by NORA industrial sector, U.S. residents age ... Lung cancer: Proportionate mortality ratio (PMR) adjusted for age, sex, and race by usual occupation, U.S. residents age 15 and ...
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor . ... Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of ... Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 ... Small cell lung cancer grows quickly and in more than half of cases the cancer has spread beyond the lung. by the time the ...
The formation of multiple small (< 2 cm) abscesses is occasionally referred to as necrotizing pneumonia or lung gangrene. ... Lung abscess is defined as necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid ... Pyogenic lung infections: factors for predicting clinical outcome of lung abscess and thoracic empyema. Curr Opin Pulm Med. ... encoded search term (Lung Abscess) and Lung Abscess What to Read Next on Medscape ...
Attendees heard a fascinating story of how disease detectives unraveled the mystery of popcorn-lung disease, and how we can ... Four of the eight workers were ill and put on lung transplant waiting lists. After investigating numerous possible sources, ... In 2000, a physician reported that eight former microwave-popcorn factory workers had developed a rare and disabling lung ... Not Everything Is Better with Butter-flavoring: Popcorn Lung Disease and the Dangers of Diacetyl ...
CDC will review e-cigarette and vaping terminology, clinical features reported among cases of lung injury in recent outbreaks, ... Clinical Team Lead, 2019 CDC Lung Injury Response. National Center for Chronic Disease Prevention and Health Promotion. Centers ... Clinical Team, 2019 CDC Lung Injury Emergency Response. National Center for Chronic Disease Prevention and Health Promotion. ... Title:Outbreak of Lung Injury Associated with E-cigarette Product Use or Vaping: Information for Clinicians ...
Breathing in very low and low levels of TCE wont irritate your lungs. Breathing in moderate concentrations may be mildly ...
Lung cancer. Lung cancer. Lung cancer begins in the cells of your lungs. ... Lung cancer is a type of cancer that begins in the lungs. Your lungs are two spongy organs in your chest that take in oxygen ... Non-small cell lung cancer. Non-small cell lung cancer is an umbrella term for several types of lung cancers. Non-small cell ... Types of lung cancer. Doctors divide lung cancer into two major types based on the appearance of lung cancer cells under the ...
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Lobectomy for Lung Cancer Case Volumes. Mass Generals lung resection volumes greatly exceed the recommended minimum standard ... Our rates of complication from lobectomy for lung cancer are relatively low. We also performed 77% of our stage 1 lung cancer ... Lobectomy for Lung Cancer Outcomes-Post-Operative Length of Stay. Mass General patients are able to leave the hospital at a ... Lobectomy for Lung Cancer Outcomes. Mass Generals outcomes are as expected, given the high number of very ill and extremely ...
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1982)‎. Reappraisal of the present situation in prevention and control of lung cancer*. Bulletin of the World Health ... Reappraisal of the present situation in prevention and control of lung cancer*. ...
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Early-Stage Non-Small Cell Lung Cancer: Mitigating the Rigors of Therapy Early-Stage Non-Small Cell Lung Cancer: Mitigating the ... COVID-19-dampened lung cancer screening rates have recovered, sort of. Rates of low-dose CT (LDCT) screening for lung cancer ... This software tries to spot lung cancer years earlier. Can it?. Lung cancer is the deadliest kind of cancer, so catching it ... Lung Cancer Screening Based on Personal Risk Is Cost-Effective. TUESDAY, Feb. 7, 2023 -- Lung cancer screening strategies based ...
Smoking damages your lungs natural cleaning and repair system and traps cancer-causing chemicals in. Smoking permanently ... damages the alveoli (air sacs) in the lungs, making it hard to breathe. ...
... and inflammation in the lung tissue. It affects the space around the small air sacs of the lung. Other parts of the lungs may ... Over time, the excess tissue that is built leads to fibrosis in the lungs. This makes it hard for oxygen to pass from the lung ... The Lung Association. http://www.lung.ca. REFERENCES:. Behr J. Approach to the diagnosis of interstitial lung disease. Clin ... Lung damage cannot be reversed. The goal of treatment is to manage symptoms, slow the disease, and improve quality of life. ...
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How Lung Cancer Develops. Understand how the lungs work, how lung cancer develops, and how it can metastasize (spread to ... Types of Lung Cancer. Not all lung cancers are the same. Learn about the two major histologic types, small cell lung cancer ( ... How Lung Cancer Develops. Understand how the lungs work, how lung cancer develops, and how it can metastasize (spread to ... Lung Nodules. Lung nodules can be quite common, and most are not cancerous, but it is important to understand what they are and ...
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... N Engl J Med. 1999 Apr 8;340(14):1081-91. doi: 10.1056/NEJM199904083401406. ...
Black Lung Benefit Awards, SSA and DOL. Title IV of the Coal Mine Health and Safety Act of 1969 authorizes a benefits program, ... Work-Related Lung Disease Surveillance System (eWoRLD). Sources of Data. Address and Employment Data, MSHA. Address and ... The Black Lung Benefits Act of 1972 continued SSA responsibility for payments to miners granted claims before July 1973, ... In September 1997, in an effort to enhance customer service to Black Lung program beneficiaries, the responsibility for ...
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Learn about the different types of lung cancer. ... it is called lung cancer.. Lung cancer begins in the lungs and ... Non-small cell lung cancer is more common than small cell lung cancer. For more information, visit the National Cancer ... Lung cancers usually are grouped into two main types called small cell and non-small cell (including adenocarcinoma and ... Cancer from other organs also may spread to the lungs. When cancer cells spread from one organ to another, they are called ...
Stella Donnelly returns with Lungs, talks up second album Flood. Al Newstead. Posted. 10 May 2022. 10 May 2022. Tue 10 May ... Musically, Lungs is a leap from the breezy guitars and comic truths of Donnellys first album as she writes from the ...
  • Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. (medlineplus.gov)
  • Somatic mutations in the TP53 , EGFR , and KRAS genes are common in lung cancers. (medlineplus.gov)
  • Smoking causes the majority of lung cancers - both in smokers and in people exposed to secondhand smoke. (mayoclinic.org)
  • Non-small cell lung cancer is an umbrella term for several types of lung cancers. (mayoclinic.org)
  • Non-small cell lung cancers include squamous cell carcinoma, adenocarcinoma and large cell carcinoma. (mayoclinic.org)
  • Asthma Tied to Increased Risk for Multiple Cancers Asthma appears to increase the risk for melanoma as well as lung, blood, kidney, and ovarian cancers, but treatment with an inhaled steroid might reduce that risk. (medscape.com)
  • Lung cancers usually are grouped into two main types called small cell and non-small cell (including adenocarcinoma and squamous cell carcinoma). (cdc.gov)
  • Not all lung cancers are preventable. (nyc.gov)
  • As with many other cancers, a key to surviving lung cancer is catching it in its earliest stages, when it is most treatable. (cancer.net)
  • Small cell lung cancer (SCLC) accounts for around 10% to 15% of all lung cancers and very rarely develops in someone who has not smoked. (cancer.net)
  • Immunotherapy helps people with a broad range of lung cancers live longer. (cancer.net)
  • The incidence of lung cancer is strongly correlated with cigarette smoking , with about 90% of lung cancers arising as a result of tobacco use. (medicinenet.com)
  • Paraneoplastic symptoms - Lung cancers frequently are accompanied by so-called paraneoplastic syndromes that result from production of hormone-like substances by the tumor cells that are released into the blood. (medicinenet.com)
  • Nonspecific symptoms - Nonspecific symptoms seen with many cancers, including lung cancers, include weight loss , weakness , and fatigue . (medicinenet.com)
  • The lung is the second organ, after the liver, in the localization of NETs, making up 25% of all NETs and 1-2% of all cancers ( 9 ). (spandidos-publications.com)
  • Lung carcinoid tumors are not common and tend to grow slower than other types of lung cancers. (cancer.org)
  • They are also found in other areas of the body, but only cancers that form from neuroendocrine cells in the lungs are called lung carcinoid tumors. (cancer.org)
  • There are few treatment options for people with these cancers once it has spread beyond the lungs. (cancer.gov)
  • Stage 3 - These cancers have spread to the lymph nodes in the center of the chest or other structures outside the lung. (moffitt.org)
  • Stage 4 - These cancers have spread to more than one area in the other lung, the fluid surrounding the lung or additional organs elsewhere in the body. (moffitt.org)
  • Small-cell lung cancers, which are very aggressive, were infrequently detected at early stages by low-dose helical CT or chest x-ray. (medpagetoday.com)
  • In the United States, air pollution is believed to contribute to around 5% of lung cancers in men and 3% in women. (verywellhealth.com)
  • Immunotherapy for Lung Cancers: First-Line and Beyond Drs West, Garon, and Borghaei discuss immunotherapy for selected lung cancers and the potential roles and pitfalls of combination immunotherapy. (medscape.com)
  • Most lung cancers do not cause symptoms until they have spread, but some people with early lung cancer do have symptoms. (medlineplus.gov)
  • If you quit smoking, even after smoking for many years, you can significantly reduce your chances of developing lung cancer. (mayoclinic.org)
  • Nonsmokers who are exposed to secondhand smoke at home or at work increase their risk of developing lung cancer by 20-30% . (medicalnewstoday.com)
  • Millions of people are especially vulnerable to the effects of air pollution, including infants, older adults and people with lung diseases like asthma. (lung.org)
  • Other parts of the lungs may be affected as these diseases worsen. (epnet.com)
  • Smoking causes far too many New Yorkers to die prematurely and suffer from lung diseases that erode their quality of life," said American Lung Association in New York President and CEO Scott T. Santarella. (qns.com)
  • In the literature, there's been different lung diseases attributed to being around the dental practice," Nett told Healthline. (healthline.com)
  • But the CDC note that, among respiratory diseases, the inhalation of silica or compounds used in dental implants can cause pneumoconiosis , when dust leads to inflammation and scarring in the lungs. (healthline.com)
  • In a data set maintained by the CDC, the report authors found that those working in dental offices were about 1.5 times more likely to die from IPF or several related lung diseases than the general population. (healthline.com)
  • They also had a significantly higher level of air trapping in their lungs, a condition associated with lung diseases. (eurekalert.org)
  • CBD (cannabidiol) may reduce the lung-damaging "cytokine storm" that can be fatal in patients with COVID-19 or other respiratory diseases. (prohealth.com)
  • 6 7 We recently reported updated associations between cumulative and maximum beryllium exposure and several diseases of a priori interest (including lung cancer), within a three-plant subcohort having detailed beryllium exposure data. (bmj.com)
  • What are the lung diseases? (kembrel.com)
  • Cystic fibrosis could be considered two diseases, one that affects multiple organs including the lungs, and one that doesn't affect the lungs at all, according to a multicenter team led by researchers at the University of Pittsburgh School of Medicine. (pitt.edu)
  • Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. (medscape.com)
  • Unlike obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), which show a normal or increased total lung capacity (TLC), restrictive disease are associated with a decreased TLC. (medscape.com)
  • The first is intrinsic lung diseases or diseases of the lung parenchyma. (medscape.com)
  • The diseases cause inflammation or scarring of the lung tissue (interstitial lung disease) or result in filling of the air spaces with exudate and debris (pneumonitis). (medscape.com)
  • They include idiopathic fibrotic diseases, connective-tissue diseases, drug-induced lung disease, environmental exposures (inorganic and organic dusts), and primary diseases of the lungs (including sarcoidosis). (medscape.com)
  • Diseases of these structures result in lung restriction, impaired ventilatory function, and respiratory failure (eg, nonmuscular diseases of the chest wall, neuromuscular disorders). (medscape.com)
  • Restrictive lung diseases are characterized by a reduction in FRC and other lung volumes because of pathology in the lungs, pleura, or structures of the thoracic cage. (medscape.com)
  • In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. (cdc.gov)
  • This latest Pharmaceutical and Healthcare disease pipeline guide Small-Cell Lung Cancer - Drugs In Development, 2022, provides an overview of the Small-Cell Lung Cancer (Oncology) pipeline landscape. (yahoo.com)
  • Pharmaceutical and Healthcare latest pipeline guide Small-Cell Lung Cancer - Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Small-Cell Lung Cancer (Oncology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (yahoo.com)
  • Take an in-depth look at many risk factors associated with lung cancer including tobacco exposure, radon, air pollution, and more. (lungevity.org)
  • Occupational exposure to diacetyl has been associated with severe respiratory impairment and obliterative bronchiolitis, a serious lung disease that is irreversible. (cdc.gov)
  • In this disease, the smallest airways in the lung (the bronchioles) become scarred and constricted, blocking the movement of air. (cdc.gov)
  • The findings from NIOSH investigations in the microwave popcorn and flavorings manufacturing industries provided a basis for a 2004 NIOSH Alert: Preventing Lung Disease in Workers Who Use or Make Flavorings . (cdc.gov)
  • Read " Coffee Workers at Risk for Lung Disease " and " Diacetyl and Food Flavorings " on the NIOSH Science Blog and share your comments. (cdc.gov)
  • Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor . (medlineplus.gov)
  • On Wednesday, January 30th the "We Were There" lecture series presented "Not Everything Is Better with Butter-flavoring: Popcorn Lung Disease and the Dangers of Diacetyl," at the Roybal Campus, Alexander D. Langmuir Auditorium . (cdc.gov)
  • In 2000, a physician reported that eight former microwave-popcorn factory workers had developed a rare and disabling lung disease, bronchiolitis obliterans. (cdc.gov)
  • Attendees heard a fascinating story of how disease detectives unraveled the mystery of popcorn-lung disease, and how we can protect workers from permanent lung damage caused by diacetyl in butter flavoring. (cdc.gov)
  • Signs and symptoms of lung cancer typically occur when the disease is advanced. (mayoclinic.org)
  • Interstitial lung disease (ILD) is a group of disorders that lead to scarring (fibrosis) and inflammation in the lung tissue. (epnet.com)
  • Behr J. Approach to the diagnosis of interstitial lung disease. (epnet.com)
  • Available at: https://www.dynamed.com/condition/interstitial-lung-disease. (epnet.com)
  • Available at: https://www.blf.org.uk/support-for-you/interstitial-lung-disease-ild. (epnet.com)
  • Title IV of the Coal Mine Health and Safety Act of 1969 authorizes a benefits program, providing medical payments and cash stipends for miners totally disabled because of pneumoconiosis arising out of employment in underground coal mining, as well as for surviving spouses of coal miners whose death resulted from the disease or who were entitled to Black Lung benefits at the time of death. (cdc.gov)
  • Whether you are a patient living with lung disease or a caregiver, join the Patient & Caregivers Network for timely education, support and connection. (lung.org)
  • Your tax-deductible donation funds lung disease and lung cancer research, new treatments, lung health education, and more. (lung.org)
  • Lung cancer may not produce noticeable symptoms in the early stages, and many people aren't diagnosed until the disease has advanced. (cancer.net)
  • Find facts about lung health, including its signs and symptoms, how it affects breathing, ways to manage the disease after a diagnosis common devices used and more. (nih.gov)
  • According to the Centers for Disease Control and Prevention (CDC), in 2018, there were 218,520 new cases of lung cancer and 142,080 related deaths in the United States. (medicalnewstoday.com)
  • Aside from lung cancer, stopping smoking also reduces the risk of developing a range of other conditions, including heart disease, osteoporosis, and diabetes . (medicalnewstoday.com)
  • Approval for squamous cell carcinoma of the lung, a disease linked with a particularly bleak poor prognosis of one-year survival post diagnosis, was based on data from the head-to-head LUX-Lung 8 trial in patients whose tumours progressed after first-line chemotherapy. (pharmatimes.com)
  • As November is Lung Cancer Awareness month, Flushing resident Carrie Wesolowski is working to promote the issue in honor of her father, who passed away from the disease last year. (qns.com)
  • Researchers at the Centers for Disease Control and Prevention (CDC) are trying to uncover why a cluster of dentists were diagnosed with a rare lung disease called idiopathic pulmonary fibrosis (IPF) . (healthline.com)
  • Acting on a tip from a dentist getting treatment for the lung disease at a Virginia clinic, the CDC found nine other dental professionals - eight dentists and one dental technician - had been treated for the same disease at the same clinic in the past decade. (healthline.com)
  • While the report is worrying, outside experts said the risk of developing lung disease is likely lower for those working in dental offices today. (healthline.com)
  • Silicosis and asbestos-related lung disease have also been identified in dentists. (healthline.com)
  • Respiratory Infections, Lung Cancer, Heart Disease…" Over 80% of premature deaths caused by small smoke particles in the United States result directly from human-ignited fires. (lcfamerica.org)
  • The lack of emphysema in the study group suggests that exposure to biomass smoke is affecting the small airways in the lungs, Dr. Kizhakke Puliyakote said, although more research is needed to understand the disease process. (eurekalert.org)
  • Extensive stage - Most people with small cell lung cancer are diagnosed with extensive stage disease, which means cancer has spread beyond the lung and to other structures in the body, which may include the fluid surrounding the lung. (moffitt.org)
  • It can also detect small nodules (early-stage lung disease) that cannot be clearly seen on chest x-rays. (medpagetoday.com)
  • If your child has been diagnosed with a lung condition or pediatric lung disease, we are the right choice for care. (cincinnatichildrens.org)
  • People who vape marijuana are still confident their products are safe despite the deaths of more than four dozen people from lung disease attributed to the practice, a survey by the Brightfield Group , a CBD and cannabis-focused market research firm, indicates. (ibtimes.com)
  • Despite the numbers, the Brightfield survey indicates 91% of THC vapers say the marijuana they use is safe while half say they haven't changed their habits since word of the lung disease first broke, with 67% saying they think the problems can be attributed to misuse. (ibtimes.com)
  • On June 17, 2019, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA, Merck) for patients with metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy and at least one other prior line of therapy. (fda.gov)
  • According to the report, a 17-year-old in Canada may be the first e-cigarette user to develop bronchiolitis obliterans, a serious disease also known as "popcorn lung. (everydayhealth.com)
  • Beryllium exposure has long been associated with an immune-mediated, granulomatous lung disease termed chronic beryllium disease. (bmj.com)
  • Coal workers' pneumoconiosis, commonly known as Black Lung disease, is reaching epidemic levels in the central Appalachian coalfields. (dailyyonder.com)
  • The central Appalachian coalfields are in the middle of an unprecedented epidemic of severe black lung disease. (dailyyonder.com)
  • The study confirmed 416 cases of the most severe form of black lung disease, Progressive Massive Fibrosis. (dailyyonder.com)
  • What is black lung disease and why is it resurging? (dailyyonder.com)
  • Some young miners have contracted severe black lung disease after just eight years working in mines. (dailyyonder.com)
  • In reporting on this epidemic, the ReSource and NPR have interviewed dozens of Appalachian miners who are struggling with severe black lung disease, including Jerry Helton and Edward Brown. (dailyyonder.com)
  • Both men contracted severe black lung disease from working in mines around the same area, but they've been left in very different situations, due to differences in the benefits and medical care they've received. (dailyyonder.com)
  • In addition, the identification will spur the launch of trials to determine if medications used by cystic fibrosis patients might have some benefit for those who do not have lung disease, but who carry the other mutations. (pitt.edu)
  • 74 females) with cystic fibrosis (CF), prospectively evaluated over an age range of 6 to 20 years, we attempted to determine whether the lung clearance index (LCI) as a measure of ventilation inhomogeneities could be a discriminating factor of disease progression. (nih.gov)
  • However, it is best known for causing coal workers' pneumoconiosis (CWP), a type of lung disease affecting the tissues and gas-exchange surface of the lung (interstitial lung disease). (cdc.gov)
  • Inhaling dusts that contain crystalline forms of silica can cause a fibrosing interstitial lung disease called silicosis. (cdc.gov)
  • To verify the association between periodontal disease and lung disease from an epidemiological, case and control survey, in patients who attended the first aid service of the Adriano Jorge Foundation Hospital, Manaus, Amazonas, Brazil, from June 2006 to February 2007. (bvsalud.org)
  • If caused by parenchymal lung disease, restrictive lung disorders are accompanied by reduced gas transfer, which may be marked clinically by desaturation after exercise. (medscape.com)
  • The mnemonic "PAINT" has been used to divide the causes of restrictive lung disease into pleural, alveolar, interstitial, neuromuscular, and thoracic cage abnormalities. (medscape.com)
  • How Can Interstitial Lung Disease Phenotypes Guide Care? (medscape.com)
  • Faces of Black Lung' features two miners who share their stories and provide insight on how their lives have changed due to this devastating black lung disease. (cdc.gov)
  • Exposure to airborne respirable crystalline silica dust can lead to silicosis, a debilitating lung disease. (cdc.gov)
  • MedPage Today) -- Risk model-based screening for lung cancer accounting for personal risk may be more cost-effective than age- and smoking history-based screening recommended by the U.S. Preventive Services Task Force (USPSTF), according to a. (medworm.com)
  • COVID-19-dampened lung cancer screening rates have recovered, sort of Rates of low-dose CT (LDCT) screening for lung cancer dropped significantl. (medworm.com)
  • Screening for lung cancer can save lives. (cancer.net)
  • The American Academy of Family Practitioners (AAFP) is currently the only major outlier with regard to recommendations on lung cancer screening and state that the evidence is insufficient to recommend for or against screening for lung cancer with LDCT in persons at high risk for lung cancer based on age and smoker history. (medscape.com)
  • Lung cancer may not cause signs or symptoms in its early stages. (medlineplus.gov)
  • we practice in Boston, where she ultimately underwent a Although this patient's isolate was resistant to the anti- bilateral lung transplant from a high-risk donor without in- microbial drugs she had received, her symptoms ultimately duction immunosuppression. (cdc.gov)
  • Lung cancer typically doesn't cause signs and symptoms in its earliest stages. (mayoclinic.org)
  • People with severe symptoms and those who are not helped by these methods may need a lung transplant . (epnet.com)
  • Screening can detect lung cancer before you start showing symptoms. (nyc.gov)
  • Symptoms of lung cancer can be nonspecific. (cancer.net)
  • What are the typical signs and symptoms of lung illness? (lunguk.org)
  • The vital point is to deal with the bronchial asthma so the kid has extremely couple of or no signs and symptoms so they are much less most likely to harm their lungs. (lunguk.org)
  • Symptoms of lung cancer are varied dependent upon the exact location of the tumor and the extent of its spread. (medicinenet.com)
  • No symptoms - Up to 25% of people who get lung cancer do not have any symptoms when the cancer is found. (medicinenet.com)
  • Symptoms related to the cancer - The growth of the cancer and invasion of the lung and surroundings may lead to symptoms such as cough , shortness of breath , wheezing , chest pain , and coughing up blood (hemoptysis). (medicinenet.com)
  • Symptoms related to metastasis (spread to other organs) - Lung cancer that has spread to the bones may produce excruciating pain at the sites of bone involvement. (medicinenet.com)
  • Symptoms of lung carcinoid tumors are cough, chest pain, and trouble breathing. (cancer.org)
  • Even in the absence of overt symptoms or breathing difficulties, the lung may have injury and inflammation that can go undetected and potentially unresolved in some people. (eurekalert.org)
  • These are all symptoms strongly related to lung injury, and it's unclear how long they will last, said lead researcher Carol Boyd, co-director of the University of Michigan's Center for the Study of Drugs, Alcohol, Smoking and Health. (homeword.com)
  • LUME-Lung 1 trial patients' reports of symptoms and health-related quality of life (HRQoL) support the use of second-line nintedanib for the treatment of advanced non-small-cell lung cancer (NSCLC). (news-medical.net)
  • Baseline health and QoL were comparable for the nintedanib and placebo groups with relatively good scores and a low burden of lung cancer-specific symptoms, such as cough and pain. (news-medical.net)
  • Similarly, the 322 patients with adenocarcinoma histology given nintedanib alongside docetaxel had a similar time to deterioration of lung cancer symptoms as the 336 given placebo, with a small benefit in global health and QoL with nintedanib detected but this did not reach significance. (news-medical.net)
  • Participants were required to have a smoking history of at least 30 pack-years and were either current or former smokers without signs, symptoms, or history of lung cancer. (medpagetoday.com)
  • Progression of fibrosing ILD is primarily reflected in a decline in lung function, worsening of symptoms, and deterioration in health-related quality of life. (medscape.com)
  • In preparing the joint statements on lung function testing for the American Thoracic Society (ATS) and the European Respiratory Society (ERS), it was agreed by the working party that the format of the statements should be modified so that they were easier to use by both technical and clinical staff. (ersjournals.com)
  • Lung transplant is a potentially life-saving option for patients with Covid-19-induced acute respiratory distress and pulmonary fibrosis. (ctsnet.org)
  • The cause of death was respiratory failure due to lung cancer. (medpagetoday.com)
  • Dental College of Georgia and Medical College of Georgia researchers reported this summer CBD's ability to improve oxygen levels and reduce inflammation as well as physical lung damage in their laboratory model of deadly adult respiratory distress syndrome, or ARDS. (prohealth.com)
  • The availability of i-lung will open the door to significant medical progress for respiratory support. (businesswire.com)
  • Of special note," added Juergen Boehm, MD, Managing Director of Xenios, "i-lung paves the way for XENiOS to continue development of a bioartificial lung for use by patients outside of a hospital environment analogous to current artificial heart protocols, which will represent a paradigm shift in the approach to long-term respiratory support. (businesswire.com)
  • Air flows to and from the alveoli as lungs inflate and deflate during each respiratory cycle. (medscape.com)
  • Lung inflation is accomplished by a contraction of respiratory, diaphragmatic, and external intercostal muscles, whereas deflation is passive at rest. (medscape.com)
  • Functional reserve capacity (FRC) is the volume of air in the lungs when the respiratory muscles are fully relaxed and no airflow is present. (medscape.com)
  • Your doctor makes treatment decisions based on which major type of lung cancer you have. (mayoclinic.org)
  • A common paraneoplastic syndrome associated with one type of lung cancer is the production of a hormone called adrenocorticotrophic hormone (ACTH) by the cancer cells, leading to oversecretion of another hormone, cortisol, by the adrenal glands ( Cushing's syndrome ). (medicinenet.com)
  • Lung carcinoid tumors (also known as lung carcinoids) are a type of lung cancer. (cancer.org)
  • The stage of non-small cell lung cancer (the most common type of lung cancer) is determined at the time of diagnosis by reviewing a patient's imaging scans. (moffitt.org)
  • Small cell lung cancer (SCLC) is a fast-growing type of lung cancer. (yahoo.com)
  • In the case of IPF, inhaling those particles can sometimes, eventually, lead to a thickening of parts of the lungs. (healthline.com)
  • See which parts of the lungs are working and which are damaged. (healthlinkbc.ca)
  • In RDS, after intratracheal administration of surfactant, surface tension is reduced, alveoli are stabilized, work of breathing is decreased, and lung compliance is increased. (medscape.com)
  • Beractant is a natural/modified bovine lung extract that lowers surface tension on alveolar surfaces during respiration and stabilizes alveoli against collapse at resting transpulmonary pressures. (medscape.com)
  • Smoking permanently damages the alveoli (air sacs) in the lungs, making it hard to breathe. (lung.ca)
  • The alveoli are where the lungs and the blood exchange oxygen and carbon dioxide during the process of breathing in and breathing out. (kembrel.com)
  • From 2014 to 2018, the death rate from lung cancer among New Yorkers was 24.3 per 100,000 people. (nyc.gov)
  • The survey was taken between December 2016 and January 2018 - prior to the wave of lung injuries among young people that occurred in 2019. (homeword.com)
  • The WHO Reporting System for Lung Cytopathology is Volume 1 of this new series of reporting systems for cytopathology, which is a joint project of the International Academy of Cytology (IAC) and the International Agency for Research on Cancer (IARC), a specialized agency of the World Health Organization (WHO). (who.int)
  • Up to a quarter of lung cancer tumors carry a genetic mutation-a genomic "glitch" that is driving the cancer's growth-that may be targeted with available medications. (cancer.net)
  • they can shrink tumors significantly, work for a long time, and provide people with lung cancer with a good quality of life. (cancer.net)
  • NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. (spandidos-publications.com)
  • The main purpose of this review, was the analysis of the available literature in all aspects while mainly focusing on molecular diagnosis data and secondly, by using this molecular landscape to establish a differentiation of lung neuroendocrine tumors (LNETs). (spandidos-publications.com)
  • Lung neuroendocrine tumors (LNETs) are a group of rare tumors with heterogenous malignancy originating in amine precursor uptake and decarboxylation (APUD) neuroendocrine cells from Kulchitsky cells (argentaffin cells) ( 1 ). (spandidos-publications.com)
  • In addition to the single pulmonary localizations there have been cases described of two or more carcinoid tumors or tumorlets of the lung, gastrointestinal tract and pancreas. (spandidos-publications.com)
  • Where do lung carcinoid tumors start? (cancer.org)
  • Lung carcinoid tumors start in neuroendocrine cells , a special kind of cell found in the lungs. (cancer.org)
  • Most carcinoid tumors form in the walls of large airways (bronchi) near the center of the lungs. (cancer.org)
  • When carcinoid tumors are found in the smaller airways (bronchioles) toward the outer edges of the lungs, they're called peripheral carcinoids . (cancer.org)
  • Are there different kinds of lung carcinoid tumors? (cancer.org)
  • There are also other types of lung cancer that are more common than lung carcinoid tumors. (cancer.org)
  • For people whose tumors do not have genetic changes matching any of the treatments being tested, they may be able to join one of the "non-match" trials that are part of Lung-Map. (cancer.gov)
  • The tumors have not grown into nearby tissues, and there are no signs of cancer outside the lung. (moffitt.org)
  • During this COCA Call, clinicians will learn about updates to prior interim recommendations for U.S. health care providers caring for patients with suspected or known lung injury associated with e-cigarette or vaping products as published in MMWR on October 11, 2019. (cdc.gov)
  • The following chart shows the Lobectomy for Lung Cancer Outcomes from July 2016 to June 2019. (massgeneral.org)
  • The National Cancer Institute estimates that there will be almost 230,000 new cases of lung cancer in 2019, which is about 13% of all new cancer cases. (medpagetoday.com)
  • They estimate that 143,000 people will die of lung cancer in 2019 (23.5% of all cancer deaths). (medpagetoday.com)
  • Small cell lung cancer (SCLC) is shown in this image. (medscape.com)
  • Lung cancer includes two main types: non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). (medpagetoday.com)
  • SCLC is the most aggressive form of lung cancer. (yahoo.com)
  • 1.1% is the Mass General mortality rate following lobectomy for lung cancer. (massgeneral.org)
  • Occupational exposure to air pollution among professional drivers significantly increased the incidence and mortality of lung cancer. (medicalnewstoday.com)
  • African American men smoke at similar rates as European American men but have higher rates of lung cancer and lung cancer mortality. (medscape.com)
  • As part of her commitment to the cause, Wesolowski is now advocating for The Lung Cancer Mortality Reduction Act. (qns.com)
  • It has been proven that screening people for lung cancer with low dose computed tomography (an X-ray machine that uses a small amount of radiation to make detailed images of the lungs) can reduce mortality by allowing to detect the cancer at an earlier stage when treatment are more effective. (who.int)
  • TUESDAY, Feb. 7, 2023 -- Lung cancer screening strategies based on personal risk are more cost effective than the 2021 U.S. Preventive Services Task Force (USPSTF) recommendations, according to a study published online Feb. 7 in the Annals of. (medworm.com)
  • MONDAY, Feb. 6, 2023 -- The best treatment for a genetically driven form of lung cancer continues to show lasting benefits, a new clinical trial update shows. (medworm.com)
  • FRIDAY, Feb. 3, 2023 -- Almost half of patients with non-small cell lung cancer (NSCLC) are not being imaged in accordance with national guidelines prior to subsequent radiation therapy, according to a study recently published in the Journal of. (medworm.com)
  • Researchers are investigating 4 main kinds of immunotherapies for lung cancer: checkpoint inhibitors, monoclonal antibodies, therapeutic vaccines, and adoptive cell therapy. (cancer.net)
  • Rapid Progression: Immunotherapy in Lung Cancer Renowned oncologists from NY-Presbyterian/Columbia University Medical Center discuss the revolutionary impact of immunotherapies for lung cancer as well as the nuances of their use in patient care. (medscape.com)
  • We report a case of Acetobacter indonesiensis pneumonia organism is not in any Food and Drug Administration-ap- in a 51-year-old woman after bilateral lung transplanta- proved databases and therefore would not have been identi- tion. (cdc.gov)
  • If a large airway is obstructed, collapse of a portion of the lung may occur and cause infections (abscesses, pneumonia ) in the obstructed area. (medicinenet.com)
  • It usually affects the lungs and causes pneumonia but also can affect other parts of the body. (cdc.gov)
  • When you inhale cigarette smoke, which is full of cancer-causing substances (carcinogens), changes in the lung tissue begin almost immediately. (mayoclinic.org)
  • Over time, the excess tissue that is built leads to fibrosis in the lungs. (epnet.com)
  • This makes it hard for oxygen to pass from the lung tissue to the blood vessels in the lungs. (epnet.com)
  • A sample of lung tissue may be taken to confirm the diagnosis. (epnet.com)
  • It was dramatic in both directions," says Dr. Babak Baban, DCG immunologist and associate dean for research, of shifting apelin levels in both circulating blood and lung tissue. (prohealth.com)
  • Apelin is a pervasive peptide made by cells in the heart, lung, brain, fat tissue and blood, and is an important regulator in bringing both blood pressure and inflammation down, says Baban, the study's corresponding author. (prohealth.com)
  • But when they looked at their ARDS model, apelin didn't do either, and instead decreased in both the lung tissue itself and the general circulation. (prohealth.com)
  • The compound was found in all lung tissue samples taken from 29 patients. (everydayhealth.com)
  • Tiny specks of coal and rock dust get lodged in the lungs and cause scarring, which prevents lung tissue from absorbing oxygen. (dailyyonder.com)
  • Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale. (mayoclinic.org)
  • Lung cancer begins in the lungs and may spread to lymph nodes or other organs in the body, such as the brain. (cdc.gov)
  • Cancer from other organs also may spread to the lungs. (cdc.gov)
  • The lungs are 2 sponge-like organs found in the chest. (cancer.org)
  • to the lungs (bronchi). (medlineplus.gov)
  • Such difficulty is caused by muscle spasm in the bronchi of the lungs. (healthy.net)
  • Bronchioles are air passages inside the lungs that branch off like tree limbs from the bronchi-the two main air passages into which air flows from the trachea (windpipe) after being inhaled through the nose or mouth. (kembrel.com)
  • The bronchi (or bronchus) are the air passages into the lungs that begin at the end of the trachea. (kembrel.com)
  • These types of lung cancer grow differently and are treated differently. (cdc.gov)
  • Two types of lung scans are usually done together. (healthlinkbc.ca)
  • A November 20 report published in the Canadian Medical Association Journal (CMAJ) raised new questions about the types of lung damage caused by vaping. (everydayhealth.com)
  • Some people with lung cancer have chest pain, frequent coughing, blood in the mucus, breathing problems, trouble swallowing or speaking, loss of appetite and weight loss, fatigue, or swelling in the face or neck. (medlineplus.gov)
  • Communities can help offer much-needed emotional support for people with lung cancer. (lungevity.org)
  • According to the CDC, around 10-20% of people with lung cancer in the U.S. never smoked or have smoked fewer than 100 cigarettes in their lives. (medicalnewstoday.com)
  • i-lung® is designed to be the world's first wearable artificial lung, a new class of devices that will serve as a steppingstone toward long-term pulmonary support and, ultimately, to an implantable bioartificial lung. (businesswire.com)
  • Setting aside scarring and fibrosis in the lungs, COVID-19 has been observed to form blood clots at abnormally high rates, with the potential to create pulmonary embolisms in the lower extremities, according to CNN . (rehabpub.com)
  • Genetic knockdown of POLQ or pharmacological inhibition by NVB decreased radioresistance in lung adenocarcinoma while causing little toxicity to normal pulmonary epithelial cells. (physiciansweekly.com)
  • Moreover, there is no single functional predictor of progression in CF, but aside from risk factors, such as onset of chronic P. aeruginosa infection and genotype, pulmonary hyperinflation, airway obstruction, and ventilation inhomogeneities are important pathophysiologic processes that should be evaluated concomitantly as determinants of lung progression in CF. (nih.gov)
  • It has been more than 35 years since the first human lung transplant procedure was performed at the University of Mississippi in a patient with severe emphysema and carcinoma of the left bronchus. (medscape.com)
  • Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. (medlineplus.gov)
  • Large cell carcinoma arises from epithelial cells that line the lungs. (medlineplus.gov)
  • When an NIEHS-led team disrupted a stress response pathway in mice, lung squamous cell carcinoma developed, suggesting a treatment target. (medworm.com)
  • US health officials have expanded the approved indications for Boehringer Ingelheim's Gilotrif, clearing its use in patients with squamous cell carcinoma of the lung. (pharmatimes.com)
  • small-cell lung cancer ( oat-cell carcinoma ) n. carcinoma of the bronchus associated with the presence of oat cells (small cells with darkly staining nuclei). (encyclopedia.com)
  • The autopsy revealed that Carr, 58, died from complications of metastatic small cell neuroendocrine carcinoma of the lung, the New York Times reports . (billboard.com)
  • Lung cancer is the leading cause of cancer deaths, accounting for an estimated 27 percent of all cancer deaths in the United States. (medlineplus.gov)
  • Lung cancer is the leading cause of cancer deaths worldwide. (mayoclinic.org)
  • Pfizer Inc. said Tuesday it ended a Phase III study for an experimental lung-cancer drug called figitumumab that had been associated with an unexpected number of deaths in testing among patients. (wsj.com)
  • Smoking - including cigarettes, cigars and pipes - is a cause in more than 80% of lung cancer deaths. (nyc.gov)
  • Lung cancer is responsible for more cancer deaths than any other cancer in men and women. (cancer.net)
  • Screening with low-dose spiral computed tomography (CT) scan has been proven to reduce lung cancer deaths in people at high risk for lung cancer. (cancer.net)
  • In fact, the National Lung Screening Trial found a 20% reduction in deaths from lung cancer among current or former heavy smokers who were screened with low-dose spiral CT, compared to those screened with a chest X-ray. (cancer.net)
  • Lung cancer is the most common cancer in men and the fifth most common in women, even causing more cancer -related deaths in women than breast cancer . (medicinenet.com)
  • The task force recognized that, although research shows that screening reduces lung cancer deaths, there are associated harms and some high-risk patients will reasonably choose not to participate in screening. (medscape.com)
  • In fact, secondhand smoke is responsible for around 2% of lung cancer deaths in the United States, or approximately 7,300 deaths per year. (verywellhealth.com)
  • When Lung-MAP was launched in 2014, it focused on one type of non-small cell lung cancer, known as squamous cell lung cancer. (cancer.gov)
  • The main purpose of this study is to evaluate the safety and efficacy of Apatinib in combination with Gefitinib as compared to placebo in combination with Gefitinib in participants with stage B-IV Non-squamous non-small-cell lung cancer (NSCLC) harboring an activating epidermal growth factor receptor (EGFR) mutation (Del19 and L858R). (centerwatch.com)
  • It affects the space around the small air sacs of the lung. (epnet.com)
  • What are tiny sacs in the lungs? (kembrel.com)
  • Tiny air sacs at the end of the bronchioles (tiny branches of air tubes in the lungs). (kembrel.com)
  • The windpipe, or trachea , brings air down into the lungs. (cancer.org)
  • As we began the new millennium, growth in the field of solid organ transplantation had spurred renewed interest of the transplant community in lung transplantation. (medscape.com)
  • Those in the field of lung transplantation have certainly learned from the perils of early experiences. (medscape.com)
  • In 1986, the Stanford group performed a successful heart-lung transplantation, which rekindled enthusiasm for the clinical application of lung transplantation. (medscape.com)
  • [ 5 ] In the same year, the Toronto Lung Transplant Group reported the first successful single-lung transplant, which led to a series of clinical advances in lung transplantation. (medscape.com)
  • Lung Transplantation - Medscape - Jun 01, 2002. (medscape.com)
  • According to the school's press release about the 5K, the survival rate for a diagnosis of lung cancer of any kind is just 17 percent, a number Seugling called 'ridiculously low. (nj1015.com)
  • New Clues to How Air Pollution Fuels Lung Cancer in Nonsmokers Air pollution may promote lung cancer in never-smokers by waking up cancer-causing cells, a finding that could have major implications for cancer prevention. (medscape.com)
  • According to the American Cancer Society, smoking continues to be the leading cause of lung cancer, but there are some other risk factors that can cause lung cancer in nonsmokers. (mercurynews.com)
  • Injury or illness can cause inflammation in the lungs and airways. (epnet.com)
  • It develops in the airways of the lungs. (cancer.net)
  • Choose from lung bags for Prestan and BigRed manikins by Brayden, or shop for Laerdal's Little Anne lung bags and Baby Anne airways - and get the supplies you need for your CPR classes. (redcross.org)
  • Mutations in the gene can lead to dysfunctional CFTR channels and thick, sticky secretions, causing problems such as the chronic lung congestion associated with cystic fibrosis. (pitt.edu)
  • Retained particle burden in the lungs of monkeys after chronic quartz dust exposure. (cdc.gov)
  • But lung cancer also occurs in people who never smoked and in those who never had prolonged exposure to secondhand smoke. (mayoclinic.org)
  • But with each repeated exposure, normal cells that line your lungs are increasingly damaged. (mayoclinic.org)
  • Exposure to nitrogen dioxide, nitrogen oxide, sulfur dioxide, and fine particulate matter were positively associated with a risk of lung cancer. (medicalnewstoday.com)
  • 15 years) and group 2 is less conservative and defined by age ≥50-, ≥20-pack year, having quit at any time, and at least one additional risk factor: (family history of lung cancer, diagnosis of COPD, occupational exposure to known carcinogen or personal history of tobacco-related malignancy). (medscape.com)
  • Exposure to radon in the home is the second-leading cause of lung cancer in the United States as well as the leading cause in non-smokers . (verywellhealth.com)
  • The Environmental Protection Agency (EPA) suggests that around 21,000 Americans get lung cancer from radon exposure each year. (verywellhealth.com)
  • Secondhand exposure to these chemicals increases a non-smoker's risk of lung cancer no less than two- to three-fold. (verywellhealth.com)
  • China Daily that lung cancer caused by smoking and cases caused by exposure to air pollution generally exhibit different characteristics. (bloomberg.com)
  • The authors recently reported updated associations between lung cancer and beryllium exposure in a large, pooled occupational cohort. (bmj.com)
  • The authors conducted the present study to evaluate the shape of exposure-response associations between different exposure metrics and lung cancer in this cohort, considering potential confounders (race, plant, professional and short-term work status, and exposure to other lung carcinogens). (bmj.com)
  • Methods The authors conducted Cox proportional hazards regression analyses of lung cancer risk with cumulative, mean and maximum 'daily weighted average' (DWA) exposure among 5436 workers, using age-based risk sets. (bmj.com)
  • The best-fitting models were generally categorical or piecewise log-linear, with the steepest increase in lung cancer risk between 0 and 10 μg/m 3 for both mean and maximum DWA exposure and between 0 and 200 μg/m 3 -days for cumulative DWA exposure. (bmj.com)
  • Conclusion This study provides evidence that lung cancer risk is elevated at levels near the current US Occupational Safety and Health Administration beryllium exposure limit of 2.0 μg/m 3 DWA for workers. (bmj.com)
  • This study finds strong quantitative associations between lung cancer and cumulative, mean and maximum beryllium exposure, after adjusting for confounding. (bmj.com)
  • Quantitative risk assessment suggests that lung cancer risk may be excessive at current occupational exposure limits. (bmj.com)
  • Especially in today's world, with emissions, with exposure to other pollutants, anything can cause lung cancer to develop in anybody,' Seugling said. (nj1015.com)
  • Avoid Exposure to Indoor Pollutants That Can Damage Your Lungs. (kembrel.com)
  • The most common risk factor for lung cancer is cigarette smoking, as well as exposure to radon, asbestos, and other types of dangerous chemicals. (medlineplus.gov)
  • Timing of RT With Immunotherapy in Metastatic NSCLC Radiotherapy followed by immunotherapy within 1-12 months ― but not sooner or later ― may boost progression-free survival in patients with metastatic non-small cell lung cancer, suggests new study. (medscape.com)
  • Lung cancer is the deadliest cancer in the world and its survival decreases with the stage at which it is diagnosed. (who.int)
  • The AEGEAN trial is the second phase 3 study, after Checkmate 816, to demonstrate a benefit from neoadjuvant immunotherapy for patients with resectable non-small cell lung cancer. (medscape.com)
  • ESMO's Practice-Changing Lung Cancer Data: Three Experts Discuss At ESMO 2017, Jack West discussed new, potentially practice-changing immunotherapy research with Hossein Borghaei and Sanjay Popat. (medscape.com)
  • First Guideline for Treating Oligometastatic NSCLC New guidance on the use of definitive local therapy to treat patients with oligometastatic non-small cell lung cancer has been issued by the American Society for Radiation Oncology and European Society for Radiotherapy and Oncology. (medscape.com)
  • NSCLC is the more common type, comprising more than 80% of all lung cancer cases. (medpagetoday.com)
  • Deeper investigation of molecular abnormalities in lung cancer has identified several specific driver mutations and biomarkers that play critical roles in the development of lung cancer, particularly NSCLC. (medpagetoday.com)
  • Radioresistance remains a major obstacle to efficacious radiotherapy in non-small cell lung cancer (NSCLC). (physiciansweekly.com)
  • They may also help control the growth of other cells in the lungs. (cancer.org)
  • Globally, in 2020, lung cancer was the second most common cancer after breast cancer, with 2.21 million cases. (medicalnewstoday.com)
  • Joining us to share the important cause that will be supported by the 2020 Fight for Air Climb are Rachel Wiesner, a Fight for Air co-chair who climbs in memory of her mom who died from lung cancer, and Mandy Reilly, who climbs in honor of her mom who died from COPD. (tmj4.com)
  • Pictures from this scan can show areas of the lungs that aren't getting enough air or that hold too much air. (healthlinkbc.ca)
  • Ideally with ARDS it would increase in areas of the lungs where it's needed to improve blood and oxygen flow to compensate and to protect," Baban says. (prohealth.com)
  • Typical carcinoids tend to grow slowly and rarely spread beyond the lungs. (cancer.org)
  • Apelin should do the same to help normalize the significant increases in inflammation in the lungs and related breathing difficulties associated with ARDS. (prohealth.com)
  • That month, Pfizer said it had halted enrollment of new patients in a trial that was testing that whether the drug could be used as a first-line treatment in patients with non-adenocarcinoma, nonsmall-cell lung cancer. (wsj.com)
  • The proportion of lung adenocarcinoma cases"-those associated with air pollution-"is increasing," Wang said. (bloomberg.com)
  • Targeting Polymerase θ impairs tumorigenesis and enhances radiosensitivity in lung adenocarcinoma. (physiciansweekly.com)
  • Learn how the lungs work and find printable resources for living with lung conditions such as asthma, COPD and more. (nih.gov)
  • However, close to 24 million adults were estimated to have impaired lung function, suggesting under-diagnosis of COPD. (cdc.gov)
  • Discuss recent advances in treatment and management of lung transplant recipients. (medscape.com)
  • This study set out to determine whether Covid-19 lung transplant patients had comparable outcomes to other lung transplant recipients with similar lung function. (ctsnet.org)
  • New York Times columnist David Carr, who died Thursday, had been suffering from lung cancer, according to autopsy results released Saturday. (billboard.com)
  • The American Cancer Society, American Association for Thoracic Surgery, American College of Chest Physicians, American Lung Association, American Society of Clinical Oncology, and American Thoracic Society, all endorse screening for populations studied in the NLST or expanded populations similar to the NCCN group 2. (medscape.com)
  • Limited stage - This refers to small cell lung cancer that is confined to one side of the chest, including cancer that that has not spread beyond the lung or has traveled to lymph nodes on the same side of the chest. (moffitt.org)
  • The NCI-sponsored National Lung Screening Trial (NLST) compared two ways of detecting lung cancer: low-dose helical computed tomography (CT) -- often referred to as spiral CT -- and standard chest X-ray. (medpagetoday.com)
  • The study findings reveal that participants who received low-dose helical CT scans had a 15% to 20% lower risk of dying from lung cancer than participants who received standard chest x-rays. (medpagetoday.com)
  • The volume of FRC is determined by the balance of the inward elastic recoil of the lungs and the outward elastic recoil of the chest wall. (medscape.com)
  • If outcomes from SARS and MERS provide an indicator of the disability that may lie head for COVID-19 survivors, these individuals may have to grapple with lingering difficult with lung function. (rehabpub.com)
  • Can Estrogen Cause Lung Cancer? (onlinecancerguide.com)
  • Previously in cystic fibrosis research, other kinds of mutations of CFTR were deemed harmless because they didn't cause lung problems, Whitcomb noted, but the Pitt-led study looked more closely at that notion. (pitt.edu)
  • An estimated 72 to 80 percent of lung cancer cases occur in tobacco smokers. (medlineplus.gov)
  • Small cell lung cancer occurs almost exclusively in heavy smokers and is less common than non-small cell lung cancer. (mayoclinic.org)
  • And although smoking is the most common cause of lung cancer, almost two-thirds of all new diagnoses are in people who have never smoked or are former smokers. (cancer.net)
  • In fact, nearly 80 percent of newly diagnosed lung cancer cases are former or never smokers. (qns.com)
  • Doctors believe smoking causes lung cancer by damaging the cells that line the lungs. (mayoclinic.org)
  • Coal Workers' Health Surveillance Program Black Lung Screenings. (cdc.gov)
  • The Black Lung Benefits Act of 1972 continued SSA responsibility for payments to miners granted claims before July 1973, assigned the Department of Labor (DOL) responsibility for claims filed after July 1973, and extended eligibility for benefits to surface coal miners and to surviving children of miners. (cdc.gov)
  • In September 1997, in an effort to enhance customer service to Black Lung program beneficiaries, the responsibility for managing all active SSA Black Lung claims was assigned to DOL. (cdc.gov)
  • This program change was made permanent in 2002 when the Black Lung Consolidation of Administrative Responsibility Act placed the administration of both programs with DOL. (cdc.gov)
  • and Division of Coal Mine Workers' Compensation, or Federal Black Lung Program at http://www.dol.gov/owcp/dcmwc/index.htm . (cdc.gov)
  • In a recent issue of the Journal of the American Medical Association federal researchers released the results of a study conducted at just three black lung clinics. (dailyyonder.com)
  • According to the authors, it's the largest number of severe black lung cases ever documented, and one of the worst industrial epidemics in American history. (dailyyonder.com)
  • An X-ray image of an Appalachian coal miner with black lung lesions. (dailyyonder.com)
  • Edward Brown is hoping to get black lung benefits. (dailyyonder.com)
  • Discover what to expect during a Low Dose CT scan for lung cancer. (lungevity.org)
  • They also used advanced CT scanning to make quantitative measurements--for instance, they acquired one scan when the person inhaled and another after they exhaled and measured the difference between the images to see how the lungs were functioning. (eurekalert.org)
  • A lung scan is a type of nuclear scanning test. (healthlinkbc.ca)
  • If the scan results don't match, you may have a blood clot in the lung. (healthlinkbc.ca)
  • Otherwise, a lung scan is usually painless. (healthlinkbc.ca)
  • Some people never know they've had histoplasmosis until a CT scan, X-ray, or other imaging test shows spots on their lungs. (cdc.gov)
  • Uncommon before the 1930s, lung cancer incidence began to rise during the 1930s as tobacco smoking became more popular. (medicinenet.com)
  • According to the American Lung Association, "providing comprehensive coverage means ensuring access to seven medications and three types of counseling recommended by the U.S. Department of Health and Human Services to treat tobacco use and nicotine dependence. (qns.com)
  • Breathing in particle pollution can increase the risk of lung cancer, according to the World Health Organization. (lung.org)
  • People who smoke have the greatest risk of lung cancer, though lung cancer can also occur in people who have never smoked. (mayoclinic.org)
  • The risk of lung cancer increases with the length of time and number of cigarettes you've smoked. (mayoclinic.org)
  • A number of factors may increase your risk of lung cancer. (mayoclinic.org)
  • Even occasional smoking can increase your risk of getting lung cancer. (nyc.gov)
  • There are several ways to reduce lung cancer risk," explained Dr. Hirsch. (medicalnewstoday.com)
  • Other smoking products are also considered to be a potential risk for lung cancer development," Dr. Hirsch said. (medicalnewstoday.com)
  • There is good evidence that pollution generated by traffic increases the risk of lung cancer. (medicalnewstoday.com)
  • Simply put, according to Dr. Hirsch, "Smoking cessation reduces the risk of lung cancer significantly. (medicalnewstoday.com)
  • OAK BROOK, Ill. - Advanced imaging with CT shows that people who cook with biomass fuels like wood are at risk of suffering considerable damage to their lungs from breathing in dangerous concentrations of pollutants and bacterial toxins, according to a study being presented at the annual meeting of the Radiological Society of North America (RSNA). (eurekalert.org)
  • Several methods are currently being studied to see if they decrease the risk of dying from lung cancer. (medpagetoday.com)
  • This can cause adverse changes to the lining of the lungs, called the pleura , and increase the risk of lung cancer over time. (verywellhealth.com)
  • But like Ted, some patients with lung cancer don't have any risk factors. (medlineplus.gov)
  • In this talk, I will explain how we used proteins measured in blood of healthy people to define their individual risk of getting a lung cancer and inform who should be screened. (who.int)
  • It is estimated that more than 222,500 people develop lung cancer each year. (medlineplus.gov)
  • Approximately 6.6 percent of individuals will develop lung cancer during their lifetime. (medlineplus.gov)
  • More men develop lung cancer than women. (nyc.gov)
  • You will now receive email updates from the American Lung Association. (lung.org)
  • While Weslowski is advocating for that legislation, the American Lung Association in New York is encouraging lawmakers in the state to enact comprehensive cessation coverage. (qns.com)
  • Select your location to view local American Lung Association events and news near you. (lung.org)