Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Tumors or cancer of the LUNG.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
The transference of either one or both of the lungs from one human or animal to another.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
A malignant epithelial tumor with a glandular organization.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Infection of the lung often accompanied by inflammation.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The circulation of the BLOOD through the LUNGS.
The excision of lung tissue including partial or total lung lobectomy.
Inhaling and exhaling the smoke of burning TOBACCO.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
A cell line derived from cultured tumor cells.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
An abnormal increase in the amount of oxygen in the tissues and organs.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Endoscopic examination, therapy or surgery of the bronchi.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A pathological accumulation of air in tissues or organs.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Measurement of volume of air inhaled or exhaled by the lung.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Functional competence of specific organs or body systems of the FETUS in utero.
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Established cell cultures that have the potential to propagate indefinitely.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A naturally radioactive element with atomic symbol Rn, atomic number 86, and atomic weight 222. It is a member of the noble gas family found in soil, and is released during the decay of radium.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Epithelial cells that line the PULMONARY ALVEOLI.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Refers to animals in the period of time just after birth.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Diseases caused by factors involved in one's employment.
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Any hindrance to the passage of air into and out of the lungs.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The volume of air remaining in the LUNGS at the end of a maximal expiration. Common abbreviation is RV.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Infections with bacteria of the genus PSEUDOMONAS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Relatively complete absence of oxygen in one or more tissues.
Measurement of oxygen and carbon dioxide in the blood.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
The upper part of the trunk between the NECK and the ABDOMEN. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Mechanical devices used to produce or assist pulmonary ventilation.
The measurement of an organ in volume, mass, or heaviness.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The act of BREATHING in.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An abnormality in lung development that is characterized by a multicystic mass resulting from an adenomatous overgrowth of the terminal BRONCHIOLES with a consequent reduction of PULMONARY ALVEOLI. This anomaly is classified into three types by the cyst size.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)
The act of BREATHING out.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
Antibodies produced by a single clone of cells.
Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Virus diseases caused by the ORTHOMYXOVIRIDAE.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Hypersensitivity pneumonitis: experimental production in calves with antigens of Micropolyspora faeni. (1/31967)

Pneumonitis was induced in calves by exposure to aerosols of Micropolyspora faeni with or without prior sensitization of the animals by subcutaneous injection of antigen. The pneumonitis primarily involved centrolobular areas and was characterized by alveolar septal thickening and loss of air space by cellular infiltration. Vasculitis and focal haemorrhage occurred in certain individuals and haemoproteinaceous exudate appeared within septa and alveolar lumina. The pneumonitis was compared with human farmer's lung, pneumonitis of housed cattle and other experimental hypersensitivity pneumonitides.  (+info)

Systemic infection with Alaria americana (Trematoda). (2/31967)

Alaria americana is a trematode, the adult of which is found in mammalian carnivores. The first case of disseminated human infection by the mesocercarial stage of this worm occurred in a 24-year-old man. The infection possibly was acquired by the eating of inadequately cooked frogs, which are intermediate hosts of the worm. The diagnosis was made during life by lung biopsy and confirmed at autopsy. The mesocercariae were present in the stomach wall, lymph nodes, liver, myocardium, pancreas and surrounding adipose tissue, spleen, kidney, lungs, brain and spinal cord. There was no host reaction to the parasites. Granulomas were present in the stomach wall, lymph nodes and liver, but the worms were not identified in them. Hypersensitivity vasculitis and a bleeding diathesis due to disseminated intravascular coagulation and a circulating anticoagulant caused his death 8 days after the onset of his illness.  (+info)

Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum. (3/31967)

Injections of killed suspensions of Corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. It is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions.  (+info)

Suppression of Moloney sarcoma virus immunity following sensitization with attenuated virus. (4/31967)

Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of normal adult BALB/c mice with attenuated MSV-M resulted in an altered pattern of tumor immunity. Injection of active MSV-M into the presensitized animals resulted in tumor induction and rejection similar to that observed in normal animals, but rejection failed to produce protection against the secondary inoculation with MSV-M. After the second inoculation with active MSV-M, tumors appeared and progressed but ultimately were rejected. Over 80% of the mice died, 25% after the primary challenge and the remainder after the secondary challenge. At death, all mice had histological evidence of leukemia which was the probable cause of death. The animals that died following the secondary challenge also had evidence of disseminated MSV-M. Solid tumor nodules were found in skeletal muscle distant from the original site of inoculation, and active MSV-M was isolated from spleen and lungs. The possibility that the results were produced by specific suppression of MSV-Moloney leukemia virus immunity is discussed.  (+info)

Factors influencing the deposition of inhaled particles. (5/31967)

Because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue, respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols. Factors influencing the deposition of inhaled particles can be classified into three main areas: (1) the physics of aerosols, (2) the anatomy of the respiratory tract and (3) the airflow patterns in the lung airways. In the physics of aerosols, the forces acting on a particle and its physical and chemical properties, such as particle size or size distribution, density, shape, hygroscopic or hydrophobic character, and chemical reactions of the particle will affect the deposition. With respect to the anatomy of the respiratory tract, important parameters are the diameters, the lengths, and the branching angles of airway segments, which determine the deposition. Physiological factors include airflow and breathing patterns, which influence particle deposition. Various lung models used in predicting particle deposition are reviewed and discussed. The air-way structures of various animal species are compared, showing the unique structure of the human lung compared to the animal species under study. Regional deposition data in man and dog are reviewed. Recent deposition data for small rodents are presented, showing regional difference in deposition with the right apical lobe having the highest relative deposition.  (+info)

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. (6/31967)

BACKGROUND: Fully adapting a forward genetic approach to mammalian systems requires efficient methods to alter systematically gene products without prior knowledge of gene sequences, while allowing for the subsequent characterization of these alterations. Ideally, these methods would also allow function to be altered in a temporally controlled manner. RESULTS: We report the development of a miniaturized cell-based assay format that enables a genetic-like approach to understanding cellular pathways in mammalian systems using small molecules, rather than mutations, as the source of gene-product alterations. This whole-cell immunodetection assay can sensitively detect changes in specific cellular macromolecules in high-density arrays of mammalian cells. Furthermore, it is compatible with screening large numbers of small molecules in nanoliter to microliter culture volumes. We refer to this assay format as a 'cytoblot', and demonstrate the use of cytoblotting to monitor biosynthetic processes such as DNA synthesis, and post-translational processes such as acetylation and phosphorylation. Finally, we demonstrate the applicability of these assays to natural-product screening through the identification of marine sponge extracts exhibiting genotype-specific inhibition of 5-bromodeoxyuridine incorporation and suppression of the anti-proliferative effect of rapamycin. CONCLUSIONS: We show that cytoblots can be used for high-throughput screening of small molecules in cell-based assays. Together with small-molecule libraries, the cytoblot assay can be used to perform chemical genetic screens analogous to those used in classical genetics and thus should be applicable to understanding a wide variety of cellular processes, especially those involving post-transitional modifications.  (+info)

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (7/31967)

We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pulmonary inflammation using mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-). Wild-type (Wt) and IL-8r-/- mice were systemically immunized to ovalbumin (OVA) and were exposed with either single or multiple challenge of aerosolized phosphate-buffered saline (OVA/PBS) or OVA (OVA/OVA). Analysis of cells recovered from bronchoalveolar lavage (BAL) revealed a diminished recruitment of neutrophils to the airway lumen after single challenge in IL-8r-/- mice compared with Wt mice, whereas multiply challenged IL-8r-/- mice had increased B cells and fewer neutrophils compared with Wt mice. Both Wt and IL-8r-/- OVA/OVA mice recruited similar numbers of eosinophils to the BAL fluid and exhibited comparable degrees of pulmonary inflammation histologically. Both total and OVA-specific IgE levels were greater in multiply challenged IL-8r-/- OVA/OVA mice than in Wt mice. Both the IL-8r-/- OVA/OVA and OVA/PBS mice were significantly less responsive to methacholine than their respective Wt groups, but both Wt and IL-8r mice showed similar degrees of enhancement after multiple allergen challenge. The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen.  (+info)

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. (8/31967)

The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia. To test whether these water channels facilitate fluid movement between airspace, interstitial, and capillary compartments, we measured passive and active fluid transport in AQP1 and AQP4 knockout mice. Airspace-capillary osmotic water permeability (Pf) was measured in isolated perfused lungs by a pleural surface fluorescence method. Pf was remarkably reduced in AQP1 (-/-) mice (measured in cm/s x 0.001, SE, n = 5-10: 17 +/- 2 [+/+]; 6.6 +/- 0.6 AQP1 [+/-]; 1.7 +/- 0.3 AQP1 [-/-]; 12 +/- 1 AQP4 [-/-]). Microvascular endothelial water permeability, measured by a related pleural surface fluorescence method in which the airspace was filled with inert perfluorocarbon, was reduced more than 10-fold in AQP1 (-/-) vs. (+/+) mice. Hydrostatically induced lung interstitial and alveolar edema was measured by a gravimetric method and by direct measurement of extravascular lung water. Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes. Active, near-isosmolar alveolar fluid absorption (Jv) was measured in in situ perfused lungs using 125I-albumin as an airspace fluid volume marker. Jv (measured in percent fluid uptake at 30 min, n = 5) in (+/+) mice was 6.0 +/- 0.6 (37 degrees C), increased to 16 +/- 1 by beta-agonists, and inhibited to less than 2.0 by amiloride, ouabain, or cooling to 23 degrees C. Jv (with isoproterenol) was not affected by aquaporin deletion (18.9 +/- 2.2 [+/+]; 16.4 +/- 1.5 AQP1 [-/-]; 16.3 +/- 1.7 AQP4 [-/-]). These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport. AQP1 facilitates hydrostatically driven lung edema but is not required for active near-isosmolar absorption of alveolar fluid.  (+info)

In order to make this discovery, they conducted the experiment in three steps. First, they injected the lung protein alone inside frog eggs to measure its function. Second, they injected both the M2 protein from H1N1 virus and the lung protein inside frog eggs and found that the H1N1 virus M2 protein caused the lung protein function to decrease significantly. By means of molecular biology techniques, scientists isolated the segment of the H1N1 virus M2 protein responsible for the damage to the lung protein and were able to demonstrate that without this segment, the H1N1 virus was unable to damage the lung protein. Third, an intact, full H1N1 virus M2 protein and the lung protein were then re-injected into frog eggs along with antioxidant drugs. This also prevented H1N1 virus M2 protein from damaging the lung protein. When these experiments were repeated using human lung cells, the results were exactly the same ...
TY - JOUR. T1 - IL-33 mediates inflammatory responses in human lung tissue cells. AU - Yagami, Akiko. AU - Orihara, Kanami. AU - Morita, Hideaki. AU - Futamura, Kyoko. AU - Hashimoto, Noriko. AU - Matsumoto, Kenji. AU - Saito, Hirohisa. AU - Matsuda, Akio. PY - 2010/11/15. Y1 - 2010/11/15. N2 - IL-33 is a member of the IL-1 family and mediates its biological effects via the ST2 receptor, which is selectively expressed on Th2 cells and mast cells. Although polymorphic variation in ST2 is strongly associated with asthma, it is currently unclear whether IL-33 acts directly on lung tissue cells at sites of airway remodeling. Therefore, we aimed to identify the IL-33-responsive cells among primary human lung tissue cells. ST2 mRNA was expressed in both endothelial and epithelial cells but not in fibroblasts or smooth muscle cells. Correspondingly, IL-33 promoted IL-8 production by both endothelial and epithelial cells but not by fibroblasts or smooth muscle cells. Transfection of ST2 small ...
In recent years, significant progress has been made in dissecting the genetic control of mammalian lung development. Many transcription factors, peptide growth factors and their receptors, as well as extracellular matrix components have been identified as important regulators of lung morphogenesis in reverse genetics approaches (Warburton et al. 2000; Groenman et al. 2004; Kumar and Ryan 2004). Chemical mutagenesis using the potent germline mutagen ENU represents a powerful means to complement these gene-driven approaches by phenotype-based screens in mice (De Angelis et al. 2000; Nolan et al. 2000; Kile et al. 2003). This report describes the positional cloning of the perinatal lethal, ENU-induced l7Rn64234SB allele and identifies a pivotal role for the previously hypothetical gene NM_026304 in Clara cell function during mouse lung development. The ENU-induced nonsense mutation truncated the carboxy-terminal 17 aa, rendering the l7Rn64234SB protein unstable. However, detection of residual ...
TY - JOUR. T1 - Low-dose of ionizing radiation enhances cell proliferation via transient ERK1/2 and p38 activation in normal human lung fibroblasts. AU - Kim, Cha Soon. AU - Kim, Jin Mo. AU - Nam, Seon Young. AU - Yang, Kwang Hee. AU - Jeong, Meeseon. AU - Kim, Hee Sun. AU - Lim, Young Khi. AU - Kim, Chong Soon. AU - Jin, Young Woo. AU - Kim, Joon. PY - 2007/9/27. Y1 - 2007/9/27. N2 - This study shows the human cellular responses and the mechanism of low-dose ionizing radiation in CCD 18 Lu cells, which are derived from normal human lung fibroblasts. Cell proliferation and viability assay were measured for the cells following γ-irradiation using trypan blue, BrdU incorporation, and Wst-1 assay. We also examined genotoxicity using a micronuclei formation assay. The activation of the MAPKs pathway was determined by Western blot analysis, and the siRNA system was used to inhibit the expression of ERK1/2 and p38. We found that 0.05 Gy of ionizing radiation stimulated cell proliferation and did not ...
Human, Mouse, Rat - Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1003 Human, Mouse, Rat - Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1003
Image: by Phil Schatz License: CC BY 4.0. Basically, a distinction is made between right and left lung. The left lung consists of two cloth (Lobi superior and inferior pulmonis sinistri), which are separated from each other by the fissura obliqua. The right lung, in turn, consists of three lobes (lobi superior, medius and inferior pulmonis dextri). The subdivision is done by the Fissura obliqua and the Fisura horizontalis pulmonis dextri. These fissures extend deep into the lung tissue and are, like the surface of the lung, lined with the visceral pleura.. The further structure is identical in both lungs. One distinguishes between the lung tip (Apex pulmonis), the lung base (Base pulmonis), the lung surfaces and the lung margins. The lung surface is covered by a serous skin, the visceral pleura, and appears pale pink in the healthy to gray. Depending on the position and the relationship to the thorax one differentiates with the lung surfaces (Facies pulmonis) between the facies costalis, ...
TY - JOUR. T1 - Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. AU - Kalinichenko, Vladimir V.. AU - Gusarova, Galina A.. AU - Kim, Il-man. AU - Shin, Brian. AU - Yoder, Helena M.. AU - Clark, Jean. AU - Sapozhnikov, Alexander M.. AU - Whitsett, Jeffrey A.. AU - Costa, Robert H.. PY - 2004/3/1. Y1 - 2004/3/1. N2 - The forkhead box (Fox) f1 transcription factor is expressed in the mouse splanchnic (visceral) mesoderm, which contributes to development of the liver, gallbladder, lung, and intestinal tract. Pulmonary hemorrhage and peripheral microvascular defects were found in approximately half of the newborn Foxf1(+/-) mice, which expressed low levels of lung Foxf1 mRNA [low-Foxf1(+/-) mice]. Microvascular development was normal in the surviving newborn high-Foxf1(+/-) mice, which compensated for pulmonary Foxf1 haploinsufficiency and expressed wild-type Foxf1 levels. To identify expression of genes regulated by Foxf1, we used Affymetrix microarrays to determine ...
Matched Pair (Normal and Carcinoma) Human Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1002 Matched Pair (Normal and Carcinoma) Human Lung Tissue Array (5 slides/pk) Cell/Tissue Protein Lysate TAS-1002
The development of lungs and the process that enables respiration is still not well understood at the molecular level. To fill the knowledge gaps, PNNL scientists are systematically characterizing normal lung development in mice and humans.
We are working with NHS Liverpool Clinical Commissioning Group to offer lung health checks to people at the Practice. This programme is known as the Liverpool Healthy Lung Programme. You can find out more about it online here: http://bit.ly/LiverpoolHealthyLungs Here you can also watch an inspiring video about Dennis, who recently attended a clinic. The clinics are offered to people aged 55-75 who have ever smoked or who have COPD (Chronic Obstructive Pulmonary Disease). If you are in this group you should receive a clinic invite letter in April, after which you should book an appointment as soon as possible. At your appointment you will see a specialist lung nurse who will ask about your general health and also some questions about your lungs and breathing. S/he may also check your breathing using Spirometry (a tube you blow in). With your permission s/he will also offer to assess your risk of lung cancer using a Lung Risk Score. If you decide to have the Lung Risk Score, you may be offered a ...
While the adult murine lung utilizes multiple restricted progenitor cells during homeostasis and fix compartmentally, very much less is known about the progenitor cells from the human lung. fix utilizing murine versions have got provided essential ideas into both lung regeneration and homeostasis. These research have got proven that the adult mouse lung epithelium can be fairly quiescent and will not really adhere to the traditional control cell model [1]. Rather, the lung shows up to conform to a maintenance structure identical to that of various other tissue with gradual turnover prices, such as the pancreas [2], [3]. During regular tissues homeostasis, abundant facultative progenitor cells located throughout the lung epithelium mediate any 1420477-60-6 manufacture required maintenance. These facultative progenitor cells, Clara cells and Type II pneumocytes, are quiescent and function as differentiated cells of the mature lung epithelium, but keep the capability to differentiate and self-renew ...
Bronchopulmonary dysplasia (BPD) remains a major respiratory illness in extremely premature infants. The biological mechanisms leading to BPD are not fully understood, although an arrest in lung development has been implicated. The current study aimed to investigate the occurrence of autophagy in the developing mouse lung and its regulatory role in airway branching and terminal sacculi formation. We found 2 windows of epithelial autophagy activation in the developing mouse lung, both resulting from AMPK activation. Inhibition of AMPK-mediated autophagy led to reduced lung branching in vitro. Conditional deletion of beclin 1 (Becn1) in mouse lung epithelial cells (Becn1Epi-KO), either at early (E10.5) or late (E16.5) gestation, resulted in lethal respiratory distress at birth or shortly after. E10.5 Becn1Epi-KO lungs displayed reduced airway branching and sacculi formation accompanied by impaired vascularization, excessive epithelial cell death, reduced mesenchymal thinning of the interstitial ...
Bronchopulmonary dysplasia (BPD) remains a major respiratory illness in extremely premature infants. The biological mechanisms leading to BPD are not fully understood, although an arrest in lung development has been implicated. The current study aimed to investigate the occurrence of autophagy in the developing mouse lung and its regulatory role in airway branching and terminal sacculi formation. We found 2 windows of epithelial autophagy activation in the developing mouse lung, both resulting from AMPK activation. Inhibition of AMPK-mediated autophagy led to reduced lung branching in vitro. Conditional deletion of beclin 1 (Becn1) in mouse lung epithelial cells (Becn1Epi-KO), either at early (E10.5) or late (E16.5) gestation, resulted in lethal respiratory distress at birth or shortly after. E10.5 Becn1Epi-KO lungs displayed reduced airway branching and sacculi formation accompanied by impaired vascularization, excessive epithelial cell death, reduced mesenchymal thinning of the interstitial ...
Carlon, Marianne ; Toelen, Jaan ; Himmelreich, Uwe ; Debyser, Zeger ; Deprest, Jan. Combined non-invasive bioluminiscence and magnetic resonance imaging improves detection after pulmonary gene transfer in a fetal mouse model.30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine (Chicago(Il), Feb 01-06, 2010). In: American Journal of Obstetrics and Gynecology, Vol. 201, no. 6, p. S261 (2009 ...
For normal lifelong lung function, the prerequisites are: (1) normal lung function at birth; (2) normal growth in lung function until the adult plateau at 20-25 years of age; and (3) no accelerated deterioration from the plateau. Cohort studies have established that lung function either tracks or deteriorates, but never improves, after the preschool years.26-28 Thus, lung function in adult life is critically dependent on in utero and post-natal lung development.. An important antenatal factor affecting newborn lung function is maternal smoking, which causes structural effects on the developing lung.29 A study in more than 13 000 people showed that childhood disadvantage defined by either maternal or paternal asthma, childhood asthma, maternal smoking and childhood respiratory infections predicts worse adult lung function, a faster rate of lung function decline, and a greater prevalence of COPD.30 Other important influences include maternal antibiotic31 and paracetamol32 use, maternal ...
Biology Assignment Help, Mammalian lungs - respiration, Mammalian Lungs - Respiration In this we will study mainly mammalian lungs as it is the best representative of a respiratory surface adapted for terrestrial respiration. For this purpose, human lung can be taken as a model as shown in Figure. Wh
Optimal lung health from embryo through adulthood requires the complex interaction of pulmonary airspaces, interstitial and vasculature, beginning with organ development and culminating in programmed senescence. Technological advances have fostered a growing appreciation for the impact of cellular plasticity and the importance of cellular niche both during development and in response to both injury and repair. In addition to expanding the role of reactivation of developmental pathways lung repair, recent discoveries have demonstrated unique aging programs that will provide novel treatment strategies for chronic lung disease. The 5th Gordon Research Conference on Lung Development, Injury and Repair in August of 2019 seeks to attract cutting edge science to drive forward the field of lung development, injury, and repair toward the goal of facilitating novel therapeutic approaches to maximize lung health across the lifespan. This conference will strive to highlight new concepts behind the interactions
The lung is the main organ in the respiratory system and doesnt develop till about week 4 in the embryo. This stage of development is known as the Embryonic stage that covers the period of week 4-5 of the developing embryo. In this stage the 2 lung buds would have formed and lung lobes and the bronchopulmonary segments. The stem diverticulum will have differentiated into trachea and larynx. The Pseudoglandular stage is the period from 6 weeks to 16 weeks in the growing fetus. The events that occur in this stage include the formation of extensive airway branching of about 14 or more generations of branching resulting in terminal bronchioles. The conducting epithelium tubes are formed and are surrounded by thick mesenchyme. At 2 months all of the segmental bronchi would have formed. The distal structures at this stage are lined with cuboidal epithelium. The next stage is the Canalicular stage, from the period of week 16 to 25. The terminal bronchioles divide into two or more respiratory ...
If you are not aware of the lung problems then see here. There is a healthy lung month that will aware you about the various lungs problems.
Research in the Cardoso lab focuses on the mechanisms that regulate lung progenitor cell fate during lung development and on the contribution of developmental mechanisms to disease pathogenesis and regeneration-repair of the adult lung. We are investigating how progenitor cells generate the wide diversity of cell types of the mature respiratory system. In this context, we have been identifying early markers of cell fate and characterizing the genetic programs associated with acquisition of the various airway epithelial cell phenotypes as the lung forms. These studies have provided insights into the role of specific pathways, including retinoids, Fgf, Tgf beta and Notch in controlling the specification and expansion of lung progenitors, airway branching and differentiation of the various lung epithelial cell lineages. Over these years Our studies continue to explore the basic mechanisms of lung development, using this knowledge to understand the role of stem/progenitor cells in lung ...
Epithelia from lung rudiments in which secondary bronchial buds are already established (14th and 13th gestational day for rat and mouse respectively) are able to undergo branching morphogenesis and cytodifferentiation in submandibular mesenchyme in vitro, whereas lung epithelium from one day younger foetuses rarely gives a morphogenetic response to submandibular mesenchyme and usually differentiates into primary (non-budding) bronchial epithelium.. The failure of 13-day rat lung epithelium to respond to submandibular mesenchyme can be prevented by peeling off the submandibular mesenchyme from the lung epithelium after 2½ days culture and replacing the same mesenchyme, or renewing it with fresh salivary mesenchyme ex vivo. Changes in the epithelial contour are visible by 10 h and buds form within 24 h; this is followed by branching morphogenesis in more than 66% of the samples.. The number of cells in S-phase in the epithelium is doubled within 3 to 5 h after the operation and the number of ...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
Lung cancer is a malignant tumour in the tissue of one or both lungs. A tumour may be found in the bronchi or in the spongy lung tissue. A tumour that starts in the lung is known as a primary lung cancer. Tumours in the lung may also be due to cancer which has spread through the blood from another part of the body such as the breast, bowel, or prostate - these cancers are called lung secondary or metastases. The following information refers to primary lung cancer.. Like other cancers, lung cancer is the result of the uncontrolled growth and multiplication of cells in the lung(s). Over time, this abnormal cell growth develops into a progressively larger mass which starts to invade functional parts of the lung, affecting breathing, causing pain and symptoms related to the loss of normal lung function. Doctors call this abnormal cluster of cells a tumour. These abnormal cells grow and divide uncontrollably and, if left untreated, eventually spread throughout the body.. ...
Aim: Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor 9 (TLR-9) in mice.. Materials and Methods: In this study, healthy male Swiss albino mice (n=30) aging 8-10 weeks were used to evaluate TLR-9 expression in lungs of mice following indoxacarb exposure with and without lipopolysaccharide (LPS). Indoxacarb was administered orally dissolved in groundnut oil at 4 and 2 mg/kg/day for 90 days. On day 91, five animals from each group were challenged with LPS/normal saline solution at 80 μg/animal. The lung tissues were processed for real time and immunohistochemical studies.. Results: LPS resulted increase in fold change m-RNA expression level of TLR-9 as compare to control, while indoxacarb (4 mg/kg) alone and in combination with LPS resulted 16.21-fold change and 29.4-fold change increase in expression of TLR-9 m-RNA, respectively, as compared to control. Similarly, indoxacarb (2 mg/kg) alone or in combination with LPS also altered TLR-9 expression. Further at protein ...
When lung cells are injured, there seems to be a cross talk between the damaged cells, the lung endothelial cells and the stem cells, explains Lee.. Lee and Kim are still trying to eavesdrop on this cross-talk, but one key factor produced by endothelial cells is a protein called thrombospondin (TSP-1). By adding it to 3-D cultures exposed to the air, mimicking the lung environment, Kim and Lee were able to prod even a single lung stem cell to start churning out alveolar cells. And by simply taking the TSP-1-rich liquid surrounding cultured endothelial cells and injecting it into the mice, they were able to reverse the lung damage caused by pulmonary fibrosis.. Conversely, when the researchers engineered lung endothelial cells to lack TSP-1 and added them to the 3-D cultures, the stem cells went down a different pathway, producing more airway cells. And in live mice unable to make TSP-1, airway repair was enhanced after injury.. TSP-1 is clearly a potential target for manipulation in patients ...
Illustration of Human lungs. Respiratory system. Healthy lungs. Light in the form of a tree. Line art. Drawing by hand. Medicine. vector art, clipart and stock vectors. Image 90830878.
With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance, says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Childrens Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. A key finding is that even after the resolution of infection, influenza results in lung parenchymal remodeling that may be critical to susceptibility to further injury, says Dr. Alcorn. This series of experiments used 6- to 8-week-old wild-type (WT) mice (C57BL/6 strain) as well as IL-22-deficient mice, infected with influenza A PR/8/34 H1N1 or control vehicle. To determine the distribution of IL-22 in the lung, they used ...
You know that smoking is bad for your lungs, but what does that mean? Heres what you need to know about the smokers lung vs. healthy lung discussion.
Stress is defined as the force applied to a material, while strain is the consequent deformation. In the whole lung, stress can be roughly approximated by the transpulmonary pressure, whereas the approximation of the average strain is the change in volume relative to the lung resting volume. The same tidal volume per kilogram may result in completely different strain according to the size of the baby lung (the V0 of the previous equation). For example, a 70-kg man with ARDS may have, according to the severity of the lung injury, a residual baby lung equal to 60%, 40%, or 20% of his normal lung size. If the ventilator is set to deliver 10 mL/kg, the actual delivered tidal volume would generate an alveolar strain, which would result from the application, in normal lung, of a tidal volume equal to 17 mL/kg, 25 mL/kg, and 50 mL/kg, values associated with a significant lung injury in laboratory studies. Recently we attempted to quantify the relationship between stress-strain and VILI in healthy ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) PAR-12-259. NIDDK
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) PAR-12-260. NIDDK
Work in the Robert H. Brown Lab explores several topics within pulmonary physiology, with a long-term goal of understanding the structural changes in the lungs that lead to the pathophysiology of lung disease. Our core studies examine the structure-function relationship of pulmonary airways and vessels as well as their role in chronic obstructive pulmonary disease (COPD) and reactive airway disease. Recent research has involved studying the mechanisms and treatment of COPD progression, new methods for treating asthma, and lung inflation and airway hyperresponsiveness. We are also exploring the impact of HIV infection on the etiology of lung disease and the pathophysiologic consequences of lung distention.. Research Areas: asthma, HIV, pulmonary physiology, lung disease, COPD, reactive airway disease ...
The NF-kappaB pathway has been shown to play a critical role in both adaptive and innate immunity and has been implicated as a focal point for induction of lung inflammation by a variety of inflammatory stimuli; however, the role of NF-kappaB in specific lung cell types remains unclear. We hypothesized that individual cell types in the lungs make important and unique contributions to the NF-kappaB dependent innate immune response. To determine the temporal and cell specific activation of NF-kappaB in vivo, an NF-kappaB reporter mouse in which expression of an enhanced green fluorescent protein (eGFP)/luciferase fusion protein cDNA driven by an NF-kappaB inducible promoter (NGL mouse) was generated. NF-kappaB activity was detected in intact, anesthetized animals by bioluminescence imaging and at the cellular level by detection of GFP on lung tissue sections. Using Eschericia coli lipopolysaccharide (LPS) and Pseudomonas aeruginosa models of lung inflammation, the timing and duration of NF-kappaB ...
To understand lung cancer, we must first understand the lungs. The lungs are two sponge-like organs in the chest. The right lung has three sections, called lobes. The left lung has two lobes. It is smaller because the heart takes up more room on that side of the body. The lungs bring air in and out, taking in oxygen and getting rid of carbon dioxide gas, which is a waste product of the body.. The lining which surrounds the lungs is called the pleura. The pleura protects the lungs. The windpipe, or trachea, brings air down into the lungs, and divides into tubes called bronchi, which divide into smaller branches called bronchioles. At the end of these small branches are tiny air sacs known as alveoli.. Most lung cancers start in the lining of the bronchi. But lung cancer can also begin in other areas such as the trachea, bronchioles, or alveoli. Lung cancer usually takes many years to develop.. ...
Patients who survive an acute lung injury are able to recover their lung function, suggesting that adult lungs regenerate to a certain extent. Depending on the cause and severity of the injury, multiple progenitor cells, including alveolar type II cells and distal airway stem cells, have been shown to drive lung tissue regeneration in mice. Now, Vaughan et al. describe another cell type involved in the repair process in mouse models lung damage from influenza virus infection or bleomycin inhalation: the rare lineage-negative epithelial progenitor (LNEP).. LNEP cells are quiescently present within normal distal mouse lung and do not express mature lineage markers, such as club cell 10 (CC10) protein and surfactant protein C (SPC). However, the authors demonstrate that these cells are activated to proliferate and migrate to damaged sites and mediate lung remodeling following major injury. Using lineage tracing approaches and cell transplantation, Vaughan et al. showed that LNEP cells, but not ...
Dendritic cells (DCs) residing in the lung are known to acquire inhaled Ag and, after migration to the draining bronchial lymph node (brLN), to present it to naive T cells in an either tolerogenic or immunogenic context. To visualize endogenous lung-derived DCs, we applied fluorescent latex beads (LXs) intratracheally, thereby in vivo labeling the majority of phagocytic cells within the lung. Of note, LX-bearing cells subsequently arriving in the draining brLN were found to represent lung-derived migratory DCs. Imaging explanted brLN by two-photon laser-scanning microscopy, we quantitatively analyzed the migration and interaction behavior of naive CD4+ T cells and endogenous, lung-derived DC presenting airway-delivered Ag under inflammatory or noninflammatory conditions. Ag-specific naive CD4+ T cells engaged in stable as well as transient contacts with LX-bearing DCs in both situations and displayed similar overall motility kinetics, including a pronounced decrease in motility at 16-20 h after ...
The use of the porcine lung to demonstrate recruitment maneuvers stimulated us to consider the possibility of using the ASL 5000 to investigate ways to improve protocols for the handling of ex-vivo perfused lungs. We believe this would provide interesting research projects for students and faculty. Many of the current ex-vivo perfusion protocols involve using positive pressure and high concentrations of oxygen to maintain isolated perfused lungs. The longest time that perfused lungs have been kept viable ex-vivo is about 10 hours. Using the ASL 5000 to model breathing, we would like to explore the possibility of extending survival time of ex-vivo perfused lungs. We believe that lowering the FiO2 and avoiding positive pressure ventilation could improve viability. Further development of this model could lead to advances in therapeutics related to airway clearance, mechanical ventilation, and airway pharmacology.. In the video below, the porcine lungs are attached to an Avea ventilator in the CPAP ...
Through the use of developmental and knock out studies Mig-6 has been shown to have a role in development. It has also been shown to be a tumour suppressor gene. Little work has been done as yet looking at its role in the adult. This study examined the role of Mig-6 in the lung with the ultimate goal being to determine if the pulmonary phenotype due to Mig-6 ablation is due to a developmental programming or loss of function in the adult. This was investigated in two ways. 1. To investigate if knocking out Mig-6 in adult lung has an effect on lung function2. Investigate the role of Mig-6 in lung epithelial cells by RNAi (Investigation of the Role of Mig-6 in Pulmonary Epithelial Cells and Vascular Cells In Vitro).Knocking out Mig-6 in the adult mice showed no difference in epithelial markers and after staining morphology and airway size were found to be normal. This would seem to indicate that the Mig-6 phenotype is due to altered development of the lungs during the neonatal period and not due to a loss
Goal of the present study is to investigate the specific cellular responses to nCeO2 and nFe2O3 in various lung cell types and develop an in vitro chronic exposure model to predict the potential fibrogenic and carcinogenic effects. Primary human lung fibroblasts were treated with nCeO2 (size dXRD = 17 nm, SSA = 61 m2/g) and direct stimulation of collagen production (a hallmark of fibrosis) was evaluated. In separate experiments, primary human small airway epithelial cells were exposed to a sub-lethal concentration (0.625 µg/cm2) of nCeO2 and nFe2O3 (size dXRD = 20 nm, SSA = 50 m2/g) for 6 weeks and their effects on cell transformation and invasion were evaluated. Our results showed new data that nCeO2 can induce a dose-dependent increase in collagen production by lung fibroblasts; nCeO2 can induce proliferation of lung epithelial cells as compared to vehicle-treated control and nFe2O3 induced neoplastic transformation of epithelial cells as determined by soft-agar colony formation assay and transwell
Intestinal bacteria transferred at birth affect lung development, bacterial resistance and susceptibility to inflammatory conditions in newborns, according to a new mouse study.
Lung development is a highly orchestrated process characterized by timed expression and activation of growth factor and protease/antiprotease systems. This interplay is essential in regulating vasculogenesis, alveolarization, and epithelial to mesenchymal transition during lung development. Alterati …
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YALE (US)-Scientists have achieved an important first step in regenerating fully functional lung tissue that can exchange gas-the key role of the lungs.. Details appear in the June 24 issue of Science Express.. Lung disease accounts for around 400,000 deaths each year in the United States. Lung tissue is difficult to regenerate because it does not generally repair or regenerate beyond the microscopic level.. The only current way to replace damaged adult lung tissue is to perform lung transplantation, which is highly susceptible to organ rejection and infection and achieves only 10 percent to 20 percent survival at 10 years.. The researchers goal was to see if it was possible to successfully implant tissue-engineered lungs, cultured in vitro, that could serve the lungs primary function of exchanging oxygen and carbon dioxide.. They took adult rat lungs and first removed their existing cellular components, preserving the extracellular matrix and hierarchical branching structures of the airways ...
The Lung Scan provides a detailed visualization of the lungs. The Advanced Lung Analysis software allows highly accurate volume measurement of lung nodules. With its 3D volume measurement, we are better able to determine changes in nodule volume and to quantify growth rate and doubling time for lesions, allowing earlier and more accurate identification of small lung cancers. This enables our radiologists to detect lung cancer at its earliest stage, usually undetectable by an ordinary chest x-ray.. The Lung Scan can also detect other lung damage such as emphysema from smoking or lung scarring from prior infection. ...
Caveolin-1 is a key regulator of pulmonary endothelial barrier function. interleukin-6, and promoted BAL neutrophilia in WT mice. Lung injury by these criteria was significantly reduced in Cav-1-/- mice but fully restored by i.v. injection of liposome/Cav-1 cDNA complexes that rescued expression of Cav-1 in lung microvessels. As thrombin is known to play a significant role in mediating stretch-induced vascular injury, we observed in cultured mouse lung microvascular endothelial cells (MLECs) thrombin-induced albumin hyperpermeability and phosphorylation of p44/42 MAP kinase in WT but not in Cav-1-/- MLECs. Thus, caveolin-1 expression is required for mechanical stretch-induced lung inflammation and endothelial hyperpermeability in vitro and in vivo. was measured in isolated lung preparations explanted from mice after two hours of injurious or control ventilation. The procedure is usually described in detail by Gorovoy in WT and Cav-1-/- mice (Fig. 2). For 125I-BSA determination, mice were ...
Small airways are abnormal in asthma [1]. One measurement of small airway function is Sacin, derived from the multiple-breath nitrogen washout (MBNW) test. Sacin reflects ventilation heterogeneity in diffusion-dependent airways, and is correlated with airway hyperresponsiveness [2] and asthma control [3]. Theoretically, heterogeneity of diffusion-dependent ventilation can arise due to the heterogeneity of cross-sectional areas of airway openings in terminal airways and the acini [4]. Therefore, Sacin may be affected by structural changes in those airways. The elastic properties of the lung may also affect Sacin, as the phase III slope, a marker of ventilation heterogeneity derived from the single-breath nitrogen washout, correlates with lung compliance in explanted lungs of smokers and in healthy lungs [5]. ...
Among adults in the United States, the prevalence of reduced lung function including obstructive and restrictive lung disease is about 20%, representing an over 40 million adults. Persons with reduced lung function often demonstrate chronic systemic inflammation, such as from elevated levels of C-reactive protein. Substantial data suggests that inflammation may have a significant role in the association between reduced lung function and cardiovascular disease (CVD); however, how reduced lung function predicts CVD as risk modification remains largely unknown. Poor lung function has been shown to be a better predictor of all-cause and cardiac-specific mortality than established risk factors such as serum cholesterol, and CVD is the leading cause of mortality among those with impaired lung function. The exact mechanism of atherosclerosis is not clear, but persistent low grade inflammation is considered as one of the culprits in clot formation. The initial presentation of coronary heart disease is either
The lung is an organ constantly exposed to microbiota either through inhalation or subclinical microaspiration from birth. Historically, medical texts allude to a sterile lung environment, and this dogma has persisted in contemporary medicine. In the last decade, a revolution of sorts has taken place in our understanding of how the lung and microbiota interact and exist. This revolution stems from new knowledge that the lung is not sterile (10) and, in fact, harbors an abundance of diverse interacting microbiota. As mentioned above, the gut microbiome modulates host mucosal defense (11, 12); however, there is a paucity of information regarding the potential role of lung microbiota to regulate immunity and homeostasis.. The lung is not sterile, contrary to centuries of dogma asserting the same. Throughout the 1900s this inference was reinforced by respiratory culture-based protocols that sought only to identify clinically significant pathogens and by a spurious conclusion that upper respiratory ...
Primary human lung cells or cell lines were cultured on a stretchable silastic membrane forming the bottom of a 12-well plexiglas® box. The box was connected to an adult ventilator and ventilated for up to 36 hours at 20 cycles/min with a pressure-volume regimen resembling that of MV. Several lung cell types were tested in this model. The alveolar macrophage was identified as the main cellular source of key inflammatory mediators, such as tumor necrosis factor, the chemokine interleukin (IL)-8, and matrix metalloproteinase-9, produced during mechanical ventilation. Mechanical ventilation also induced low levels of IL-8 secretion by human alveolar epithelial type II-like cells. Other lung cell types such as endothelial cells, bronchial cells, and fibroblasts failed to produce IL-8 in response to mechanical ventilation (1,2). Conclusions and Relevance for 3R ...
By Claire Mulvihill, Lung Cancer Support Nurse, Lung Foundation Australia. There are a number of symptoms and side effects which you may experience when living with lung cancer and other lung diseases in addition to various treatments. Lung cancer and its treatment can affect people in different ways depending on the type, location and size of your lung cancer. You may have general symptoms and not feel well, or have very specific symptoms relating to your lungs or other parts of the body that have been affected by the cancer. Whilst there are a number of side effects which you may experience, in this edition we feature breathlessness and some tips to managing this. We will highlight other common symptoms in such as weight loss and fatigue in future editions.. Shortness of breath is the most common challenge people living with lung cancer and other lung diseases have. It can be uncomfortable and scary and you may feel like you cant get enough air into your lungs. The common causes of ...
... lining the outside of the lung and the wall of the chest cavity. Lung cancer and breast cancer account for about 50-65% of ... Chest radiograph is usually performed first and may demonstrate an underlying lung cancer as well as the pleural effusion. ... Lung. 181 (6): 329-34. doi:10.1007/s00408-003-1035-9. PMID 14749937. Gaspar MJ, De Miguel J, García Díaz JD, Díez M (2008). " ...
"LUNG". Helen Monks. Retrieved 12 August 2019. "About LUNG". LUNG. 1 February 2017. Retrieved 12 August 2019. Laws, Roz (11 ... Monks co-founded the Barnsley-based touring theatre company LUNG Theatre in 2012. Lung is "a political documentary theatre ...
Lung. 185 (1): 1-7. doi:10.1007/s00408-006-0053-9. ISSN 0341-2040. PMID 17294338. "Sur une forme particulière d'atrophie ...
Surgery may be needed to repair the hole in the trachea, esophagus or bowel.[citation needed] If there is lung collapse, it is ... Although painful, this allows full inflation of the unaffected lung. Laënnec RTH. De l'auscultation médiate ou Traité du ... Lung. 185 (6): 373. doi:10.1007/s00408-007-9037-7. PMID 17909893. S2CID 6771220. Utsumi T, Shiono H, Fukai I, Akashi A (2007 ... the condition can result from physical trauma or other situations that lead to air escaping from the lungs, airways, or bowel ...
... and the higher lung expansion of rib cage breathing is referred to as 'shallow'. The actual volume of air taken into the lungs ... Due to the lung expansion being lower (inferior) on the body as opposed to higher up (superior), it is referred to as 'deep' ... Air enters the lungs as the diaphragm strongly contracts, but unlike during traditional relaxed breathing (eupnea) the ... Diaphragmatic breathing helps decrease the cortisol levels through its technique of expanding the lungs into the diaphragm in ...
Heart Lung. 29 (4): 306-8. doi:10.1067/mhl.2000.106723. PMID 10900069. Maetz, Benjamin; Abbou, Ralph; Andreoletti, Jean ...
"White Lung". Pitchfork. Retrieved 5 October 2013. CS1 maint: discouraged parameter (link) Allmusic. "White Lung". Allmusic. ... "White Lung - Deep Fantasy - Album Reviews - Consequence of Sound". Consequence of Sound. 17 June 2014. "SCREAMING FEMALES: Wiki ... Tacocat Tattle Tale Team Dresch The Third Sex Throwing Up Tribe 8 Tunabunny The Tuts Voodoo Queens Wetdog Wild Flag White Lung ...
Velayos, FS; Williamson, A; Sousa, KH; Lung, E; Bostrom, A; Weber, EJ; Ostroff, JW; Terdiman, JP (June 2004). "Early predictors ...
Metastasis occurs in approximately 50% of cases with the most frequent occurrence in the lungs, which is common site of ... Lung India. 34 (2): 170-172. doi:10.4103/0970-2113.201312. ISSN 0970-2113. PMC 5351361. PMID 28360467. Molecular and Cellular ...
"1997 FCC DTV Allocations". Doug Lung. February 10, 2005. "FOX Coming to Max Media of Montana Stations". ABC Montana. June 3, ... Bill S.2507 (2007), "DTV Border Fix Act of 2007" from OpenCongress.org Lung, Doug (December 24, 2008). "President Signs 'Analog ...
Lung. 45 (4): 363-371. doi:10.1016/j.hrtlng.2016.04.006. PMID 27377334. da Silva, Paulo Sérgio Lucas; Farah, Daniela; Fonseca, ... Lung. 46 (6): 444-451. doi:10.1016/j.hrtlng.2017.08.006. PMID 28912056. Heavey, Elizabeth (2011-08-24). Statistics for Nursing ...
"European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel". Ca. 48 (3): 167-76, discussion ... Lung cancer death rates in the United States have mirrored smoking patterns, with increases in smoking followed by dramatic ... Millions of workers run the risk of developing cancers such as lung cancer and mesothelioma from inhaling asbestos fibers and ... Job stress does not appear to be a significant factor at least in lung, colorectal, breast and prostate cancers. Tobacco ...
Mutlu H, Alam M, Ozbilgin OF (2011). "A rare case of Epstein-Barr virus-induced dilated cardiomyopathy". Heart Lung. 40 (1): 81 ...
Association, Lung. "History: Support Christmas Seals". Canadian Lung Association. Archived from the original on 15 November ... Today the Christmas seals benefit the American Lung Association and other lung related issues. Tuberculosis was declining, but ... The Canadian Lung Association's Christmas seals continue to symbolize the grassroots support of Canadians that helped win the ... In 1987 the American Lung Association acquired a trademark for the term "Christmas Seals" to protect their right to be the sole ...
Heart Lung. 2020;49(5):444-445. doi:10.1016/j.hrtlng.2020.03.018. Booth, A. W. G.; Vidhani, K.; Lee, P. K.; Thomsett, C.-M. ( ... Its mechanism of action is the application of mild positive airway pressure and lung volume recruitment. HFT, the clinician can ... "Domiciliary humidification improves lung mucociliary clearance in patients with bronchiectasis". Chronic Respiratory Disease. 5 ... Impact on Oxygenation and Ventilation in an Acute Lung Model". Pediatric Pulmonology. 46 (1): 67-74. doi:10.1002/ppul.21326. ...
Lung tumor biological mechanisms may demonstrate distinct and complex imaging patterns. In particular, Aerts et al. (2014) ... For example, thirty-five CT-based radiomic features were identified to be predictive of distant metastasis of lung cancer in a ... They also confirmed that the prognostic ability of these radiomics features may be transferred from lung to head-and-neck ... 2014) performed the first large-scale radiomic study that included three lung and two head-and-neck cancer cohorts, consisting ...
Lung Dis. 66 (4): 211-3. PMID 1813098. "Dr. Karel Styblo Symposium: An Emerging Global Programme Against Tuberculosis. The ... Lung Dis. 66 (4): 139-214. December 1991. PMID 1687506. Christie D; Tansey EM, eds. (2005). "Short-course chemotherapy for ... The International Union Against Tuberculosis and Lung Diseases (IUATLD) instituted the Karel Styblo Public Health Prize after ... CS1 maint: discouraged parameter (link) "About the Union Awards". International Union against Tuberculosis and Lung Disease. ...
"iron lung." online exhibit. Archived 2007-03-11 at the Wayback Machine University of Virginia, Claude Moore Health Sciences ... He studied, taught, and wrote textbooks and scholarly works on a variety of topics in industrial hygiene; the iron lung itself ... With Louis Agassiz Shaw, he invented the first widely used iron lung in 1928. Drinker's father was railroad man and Lehigh ...
Non-smokers exposed to cigarette smoke in the workplace have an increased lung cancer risk of 16-19%. A study issued in 2002 by ... Other benefits of smoking bans in bars and restaurants include improved lung function and a decrease in smoking rates among ... Research has generated evidence that second-hand smoke causes the same problems as direct smoking, including lung cancer, ... Lung Cancer. 45 (Suppl 2): S3-9. doi:10.1016/j.lungcan.2004.07.998. PMID 15552776. Jerry Markon; Renae Merle (13 April 2004). " ...
"Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells". Lung Cancer. 50 (1): 19-24. doi: ... Shimura S, Takishima T (1994). "Bronchorrhea from diffuse lymphangitic metastasis of colon carcinoma to the lung". Chest. 105 ( ... Lung Cancer. 49 (1): 125-8. doi:10.1016/j.lungcan.2004.11.027. PMID 15949598. Milton D, Kris M, Gomez J, Feinstein M (2005). " ... "Successful treatment of bronchorrhea with octreotide in a patient with adenocarcinoma of the lung". J Pain Symptom Manage. 32 ( ...
Lung Dis. 13 (12): 1536-41. PMID 19919773. Kubica, T.; Rusch-Gerdes, S.; Niemann, S. (1 July 2003). "Mycobacterium bovis subsp ...
... lung cancer. Sergio Chávez Saldaña (88), Chihuahua surgeon and teacher (b. Oct 17, 1929). March 18: Sergio García (78), ... lung infection. February 17: "Don Sshinda" (Gumercindo España Olivares), 83, wooden toy handicrafter (b. 1935). February 18: ...
Heart Lung. 27 (2): 146-8. doi:10.1016/s0147-9563(98)90023-1. PMID 9548071. Griffith DP, Musher DM, Itin C (1976). "Urease. The ...
"Pigeon fancier's lung" (Web Article). BMJ. Retrieved 2008-01-05. "Pigeon Lung". British Pigeon Fanciers Medical Research. ... Keeping pigeons has been found to lead to a condition called pigeon fancier's lung in some fanciers. Pigeon fancier's lung is ...
The Naiads hatch after two weeks and are born with three gills for respiration (Lung 2001). Naiads are found in rivers, streams ... Lung, Mark; Sommer, Stefan (2001). "Macromiidae: The Cruisers". Dragonflies Index. Retrieved 2006-04-04. Martin Schorr; Martin ...
Muschitz, C.; Dimai, H. P.; Kocijan, R.; Kaider, A.; Zendeli, A.; Kühne, F.; Trubrich, A.; Lung, S.; Waneck, R. (2013-08-01). " ...
2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' ... survival" (PDF). Lung Cancer. 55 (3): 271-7. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016. PMID 17145094. v t e. ... "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 ...
Weber pianos website "Wendl & Lung". Wendl & Lung. Retrieved 2021-02-08. "The Canadian Encyclopedia, Willis & Company Ltd". ...
Lung Cancer. 48 (1): 137-40. doi:10.1016/j.lungcan.2004.09.008. PMID 15777981. Sharkey KA, Darmani NA, Parker LA (January 2014 ...
Gouder, C; Montefort, S (2014). "Potential impact of fireworks on respiratory health". Lung India. 31 (4): 375. doi:10.4103/ ... Gouder, Caroline; Montefort, Stephen (2014). "Potential impact of fireworks on respiratory health". Lung India. 31 (4): 375-9. ...
The Lung Biology laboratories seek to identify the novel mechanisms of lung inflammation and host defense, and explore how ... Lung Biology Research. Louisiana is one of the states in the U. S. which has high prevalence of pulmonary diseases, such as ... The Lung Biology group in the Schol of Veterinary Medicine (SVM) uses vertically integrated experimental cutting edge ... The scientific focus of the members working in Lung Biology range from innate immunity, adaptive immunity and immunotherapy. ...
There is a healthy lung month that will aware you about the various lungs problems. ... If you are not aware of the lung problems then see here. ... The greater the lung capacity the easier it is to provide your ... blood pump going and get the lungs inhaling and exhaling and thereby help to sustain lung capacity or even increase your lung ... October is National healthy lung month, a month that for many people causes multiple problems pertaining to their lungs. ...
Smoking inhibits lungs immune cells. (Biomedicine) by Science News; Science and technology, general Immune response Analysis ... Smoking inhibits lungs immune cells Epidemiologic studies indicate cigarette smokers are more susceptible than nonsmokers to ... Lung cancer: high death rate with HIV, huge reduction possible with CT screening for early diagnosis.. ... They report that cigarette smoke preferentially depreses the function of immune cells in lymph nodes that lie within the lung ...
... product use associated lung injury (EVALI). Learn CDCs recommendations, and the latest outbreak information. ... Outbreak of Lung Injury Associated with E-cigarette Use, or Vapingplus icon*For Healthcare Providers ... Vitamin E acetate has been found in product samples tested by FDA and state laboratories and in patient lung fluid samples ... As of February 18, 2020, a total of 2,807 hospitalized e-cigarette, or vaping, product use-associated lung injury (EVALI) cases ...
... is a lung disease that makes breathing difficult for millions of Americans. There is no cure for asthma, but the good ... What is LUNG FORCE?. LUNG FORCE unites women and their loved ones across the country to stand together in the fight against ... American Lung Association , 1-800-LUNGUSA (1-800-586-4872)1-800-LUNGUSA , Submit A Question Live Chat ... Asthma is a lung disease that makes breathing difficult for millions of Americans. There is no cure for asthma, but the good ...
Check out these 5 easy steps to increase lung capacity for better breathing. Keep reading to learn more and call us at (800) ... For people with lung disease, lung function and lung capacity can diminish over time. Lung function is a metric determined by ... Simply put, lung function is how your body uses air while lung capacity is how much air your body can use. While lung function ... Lung capacity differs from lung function because lung capacity is the maximum amount of oxygen your body can use. ...
Humans have two lungs, a right lung and a left lung. They are situated within the thoracic cavity of the chest. The right lung ... The left lung (left) and right lung (right). The lobes of the lungs can be seen, and the central root of the lung is also ... These fixed size lungs are called "circulatory lungs", as distinct from the "bellows-type lungs" found in most other animals.[ ... Some types of chronic lung diseases are classified as restrictive lung disease, because of a restriction in the amount of lung ...
Learn what lung cancer is, what the symptoms are, how to lower your risk, and who should be screened for lung cancer. ... Not all lung cancers are caused by smoking. Learn about lung cancer in nonsmokers. ... You can play a key role in reducing the burden of lung cancer, the number one cause of cancer death in the United States. See ... Lung cancer is the third most common cancer in the United States. The Data Visualizations Tool provides detailed statistics. ...
White lung or white lung syndrome may refer to: Acute respiratory distress syndrome Asbestosis Pulmonary alveolar ... a Canadian punk rock group This disambiguation page lists articles associated with the title White lung. If an internal link ...
Permanent lung damage can arise due to ones inability to recognize the cause of symptoms. Farmers lung occurs because ... After multiple exposures, it takes less and less of the antigens to set off the reaction in the lung. Farmers lung disease is ... examining lung tissue • performing an immunological investigation • performing a lung function test • reviewing the clinical ... Diagnoses of Farmers lung is difficult due to its similarity to cold and flu-like symptoms. Doctors diagnose patients with ...
Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA] [ http://en.wikipedia.org/wiki/Right_lung ... Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well ... right lung. Go to external page http://purl.obolibrary.org/obo/UBERON_0002167 Copy ...
Find out about lung transplants, including when one is needed, the different types of transplant, what the procedure involves ... When a lung transplant is needed. A lung transplant will often be recommended if:. *a person has advanced lung disease that ... a heart-lung transplant - where the heart and both lungs are removed and replaced with a donated heart and lungs; this is often ... a single lung transplant - where a single damaged lung is removed from the recipient and replaced with a lung from the donor; ...
What are the safest and least invasive ways to diagnose and evaluate lung nodules? This review provides an overview of the ... Lung Nodule Management. An Interventional Pulmonology Perspective. Udit Chaddha, MBBS; Jonathan S. Kurman, MD, MBA; Amit ... Using specialized planning software, an avascular, straight-line path through the lung parenchyma to the target lesion is ... When to Add Chemotherapy to IO in Lung Cancer? New Data from ASCO 2020 ...
TYPES OF LUNG CANCER A cancer arising in the 20% epithelial tissue of the 80% skin or of the lining of Non-small cell lung ... Lung cancer (Animated) * 1. INTRODUCTIONWhy What How * 2. CancerWHAT IS LUNG CANCER (Bronchogenic) Or Carcinoma Genetic damage ... Central area of the lung. * 19. Non-Small Cell Lung Cancer Large Cell Carcinoma (LCC) largest The cells are generally highly ... LUNG CANCER SPREADSpread of the tumour can occur by the lymphatic vessels to lymphnodes located within the lung, mediastinum ...
Whos paying the cost of lung transplants for work-related lung diseases?. ... Thirty four of the lung transplants (72%) were performed since 2008. The medical costs for a bilateral lung transplant are ... Branhams lungs were hardened by coal mine dust. It was painful to listen yet the perfect punctuation for a powerful story. ... For more than 50 years, he diagnosed and treated coal miners with work-related lung disease, first at the then Miners Memorial ...
What are the safest and least invasive ways to diagnose and evaluate lung nodules? This review provides an overview of the ... Lung Nodule Management. An Interventional Pulmonology Perspective. Udit Chaddha, MBBS; Jonathan S. Kurman, MD, MBA; Amit ... News Best Treatment of Extensive-Stage Lung Cancer Includes PD-L1 Inhibitor and Etoposide ... News Lorlatinib Surpasses Crizotinib as First-Line Treatment for Advanced ALK+ Lung Cancer ...
Acute Lung Injury Treatment Market is expected to grow healthy rate in near future; Acute lung injury is observed as a part of ... Acute Lung Injury Treatment Market report presents a detailed overview of the present scope of growth for companies operating; ... systemic inflammatory process wherein the lung manifests symptoms similar to other tissues such as destruction in capillary ... Global Acute Lung Injury Treatment Market: Insight into Key Aspects. Acute lung injury is a part of the systemic inflammatory ...
Farmers Lung. Br Med J 1965; 2 doi: https://doi.org/10.1136/bmj.2.5453.59 (Published 10 July 1965) Cite this as: Br Med J 1965 ...
Lung cancer. Lung cancer refers to primary tumours of the lung and is initially classified histologically as small cell lung ... Lung cancer incidence statistics. 2014. www.cancerresearchuk.org/cancer-info/cancerstats/types/lung/incidence/uk-lung-cancer- ... Lung cancer accounts for 22% of deaths from cancer in the UK. An average GP will see about one new diagnosis of lung cancer ... Lung cancer is harder to diagnose than most other cancers so the diagnosis is often delayed. There is evidence from recent well ...
Lung Transplantation Lung transplantation research such as mechanisms of acute cellular and antibody-mediated rejection; ... primary graft dysfunction; and chronic lung allograft dysfunction, including bronchiolitis obliterans and restrictive allograft ...
... is a disease in which the cells of the lung tissues grow uncontrollably and form tumors. It is the leading cause of death from ... Types of lung cancer. There are two kinds of lung cancers, primary and secondary. Primary lung cancer starts in the lung itself ... Primary lung cancer (also called adenocarcinoma) starts in the lung itself. Primary lung cancer is divided into small cell lung ... There are two kinds of lung cancer, primary and secondary. Primary lung cancer starts in the lungs. Secondary lung cancer ...
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. ... Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of ... Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 ... Small cell lung cancer grows quickly and in more than half of cases the cancer has spread beyond the lung. by the time the ...
Learn the surprising signs that you could be dealing with lung cancer. Coughing and chest pain are the better-known ones, but ... Is It Lung Cancer?. In its early stages, lung cancer doesnt typically have symptoms you can see or feel. Later, it often ... Someone with lung cancer is more likely to get a blood clot in their legs or arms (called deep vein thrombosis) and lungs ( ... Its rare for lung cancer to be the cause of gynecomastia, but its possible. Large-cell lung cancer can disrupt your hormone ...
The American Lung Association is the leading organization working to save lives by improving lung health and preventing lung ... The American Lung Association is the leading organization working to save lives by improving lung health and preventing lung ...
Lung cancer is one of the worlds most common cancers. It is the deadliest cancer in the United States. Most cases are caused ... Lung cancer is abnormal growth of cells in the lungs. It is one of the most common forms of cancer in the world. More people in ... Lung cancer is often found on an X-ray or CT scan being done for another reason. If you have symptoms of lung cancer, your ... There are 2 types of lung cancer:. Non-small cell - This is the most common form of lung cancer. More than 85% of people with ...
Studying Lung Cancer Causes and Prevention. Society researchers in other program areas are conducting different types of lung ... Chong is focused on lung cancer patients who have a mutation in a gene called EGFR as this form of lung cancer very often ... Our long-term follow-up studies confirmed the link between smoking and lung cancer, secondhand smoke and lung cancer, and radon ... and how lung cancer patients quality of life can be improved. These efforts have helped reduce lung cancer death rates in men ...
Lung, in air-breathing vertebrates, either of the two large organs of respiration located in the chest cavity and responsible ... Each lung is divided into lobes separated from one another by a tissue fissure. The right lung has three major lobes; the left ... Medial view of the right lung.. Encyclopædia Britannica, Inc.. In the inner side of each lung, about two-thirds of the distance ... The lungs always remain somewhat inflated because of a partial vacuum between the membrane covering the lung and that which ...
If you or your loved one has been diagnosed with lung cancer, Memorial Sloan Kettering is ready to help. Find a doctor and ... Types of Lung Cancer. There are two main types of lung cancer. The type you have depends on which kind of cells the cancer ... Non-small cell lung cancer is more common than small cell lung cancer, which tends to grow and spread faster than non-small ... Lung cancer is one of the most commonly diagnosed cancers. It develops when abnormalities occur in either the lungs or the ...
... lung cancer is responsible for the majority of cancer-related deaths. The American Cancer Society estim… ... Oklahoma CyberKnife: Lung Cancer Awareness * 1. Lung Cancer Awareness Month * 2. November is Lung Cancer Awareness Month ... Lung tumors are a frequently treated disease at our center. Oklahoma CyberKnife is a service of Hillcrest Medical Center. ... 3. The Facts: Lung cancer is the leading cause of cancer death. • It is estimated that smoking is the principal cause of about ...
... heart and lung transplant surgeons have followed a strict directive: Get the donor organ into the recipient as soon as possible ... "Its converting lungs you cant use into lungs you can use. At the moment, we are only using about 20%, worldwide, of the lungs ... Lungs must be able to function immediately once transplanted. For that reason, surgeons are very selective about which lungs ... "Many lungs are useable but we cant really assess them well enough to be sure so we dont use them," he said. ...
... scan to measure air flow in your lungs and a perfusion (Q) scan to see where blood flows in your lungs. The test can help ... diagnose a pulmonary embolism, or a blood clot in your lung. Learn more about the test and how to participate in a clinical ... A lung VQ scan is an imaging test that uses a ventilation (V) ... Lung VQ Scan Also known as Lung or Pulmonary Ventilation (V) ... A lung VQ scan is an imaging test that uses a ventilation (V) scan to measure air flow in your lungs and a perfusion (Q) scan ...
Chapter 72: Cancer of the lung: Non-small cell lung cancer and small cell lung cancer. In: Niederhuber JE, Armitage JO, ... Small Cell Lung Cancer Stages. After someone is diagnosed with small cell lung cancer (SCLC), doctors will try to figure out if ... This describes cancers that have spread widely throughout the lung, to the other lung, to lymph nodes on the other side of the ... This generally includes cancers that are only in one lung (unless tumors are widespread throughout the lung), and that might ...
... and lungs . Source for information on Heart-Lung Machines: Gale Encyclopedia of Nursing and Allied Health dictionary. ... Heart-lung machinesDefinitionThe heart-lung machine is medical equipment that provides cardiopulmonary bypass or mechanical ... The heart-lung machine is invaluable during this time since the patient is unable to maintain blood flow to the lungs or the ... Heart-lung machines. Definition. The heart-lung machine is medical equipment that provides cardiopulmonary bypass or mechanical ...
  • Severe medical issues such as bronchitis, emphysema, cardiopulmonary disease, high blood pressure (which can lead to heart attack and stroke), vasoconstriction (constricted/narrowed blood vessels) which also may lead to heart attack and stroke, DVT (deep vein thrombosis (blood clot )), pulmonary embolism, as well as being carcinogenic which can cause cancer in the lungs, mouth and throat. (healthstatus.com)
  • If not, you could be putting yourself at risk for a host of respiratory problems, including asthma, chronic obstructive pulmonary disease (COPD), pneumonia, tuberculosis, and lung cancer. (qualityhealth.com)
  • They report that cigarette smoke preferentially depreses the function of immune cells in lymph nodes that lie within the lung tissue, and that only prolonged smoke exposure induces changes in immune cells stored in other parts of the body. (thefreelibrary.com)
  • Shopp warns that non-immune-related factors--such as the breakdown of lung tissue or emphysema -- also could contribute to smokers' increased susceptibility to respiratory infections. (thefreelibrary.com)
  • Different disorders are caused depending on the different parts of the lungs that are affected, like the airways (the tubes that carry oxygen and other gases through the lungs), the lung tissue, or the blood vessels in the lung. (feinsteininstitute.org)
  • Asthma for instance affects the airways, pulmonary fibrosis affects the lung tissue, and pulmonary hypertension affects the blood vessels in the lung. (feinsteininstitute.org)
  • A high resolution histology image of lung tissue (background), and the tree-like respiratory system. (pnnl.gov)
  • One, led by staff scientists Geremy Clair and Paul Piehowski, used a novel platform for ultrasensitive analysis to characterize, for the first time, the ontogeny of protein changes during normal lung development in minute microdissected alveolar tissue. (pnnl.gov)
  • While the paper by Dautel and Kyle examined whole-lung samples, the paper by Clair and Piehowski focused on analysis at a much finer resolution by looking at microdissected alveolar tissue. (pnnl.gov)
  • From time-points roughly equivalent to early lung development in humans (in-utero mice at gestational day 16.5 and mice at postnatal days 7 and 28) they examined minute microdissected alveolar tissue representing only 4,000 lung cells. (pnnl.gov)
  • Impressively, their ultra-small scale analysis allowed characterization of more than 3,400 proteins, providing the first in-depth global characterization of the ontogeny of protein changes in microdissected alveolar tissue during normal lung development. (pnnl.gov)
  • These are airway tubes from the trachea to the lungs. (baycare.org)
  • Mucous membranes in the nose and mouth moisten and warm the air, but they also trap foreign particles, pathogens, and external threats from entering the trachea (windpipe) and lungs. (dherbs.com)
  • The mammalian lung consists of a complex, tree-like structure, wherein branched airways terminate in alveoli that exchange gases with the blood. (aiche.org)
  • In the avian lung, airways that begin terminally branched during development eventually come together and fuse, creating a closed circuit of airways that interweave with vasculature to exchange gases. (aiche.org)
  • These new branches are similar in morphology to the branches observed in the early mouse lung, with a similar pattern of smooth muscle coverage, suggesting a role for smooth muscle in shaping the airways and facilitating fusion. (aiche.org)
  • People with chronic lung conditions like asthma, chronic obstructive pulmonary disease (COPD), or bronchitis experience inflamed airways that make it difficult for air to circulate the lungs. (dherbs.com)
  • Coughing is the body's attempt to get rid of mucus, but coughing that is out of your control can make things worse because your airways close, trapping mucus in the lungs. (dherbs.com)
  • The most basic lung structures are found in reptiles, some of which have lungs which are simple epithelial pouches with only rudimentary corrugations along the surface to increase surface area. (aiche.org)
  • We aim to use these insights to manipulate smooth muscle differentiation in the developing lung in order to direct epithelial morphogenesis, ultimately gaining precise mechanical control over these developing tissues. (aiche.org)
  • Lung disease comprises many disorders that involve the lungs and prevent them from working properly. (feinsteininstitute.org)
  • These questions are answered while following exciting new discoveries that may prove beneficial for patients with chronic lung disease. (feinsteininstitute.org)
  • Feinstein Institute investigator who studies lung disease is Edmund Miller . (feinsteininstitute.org)
  • This is the area between the lungs and the chest wall. (baycare.org)
  • The chest wall surrounds the lungs. (baycare.org)
  • To raise public awareness about the importance of lung health, a number of health-related organizations including the American Association of Respiratory Care (AARC), the American Thoracic Society, and the American College of Chest Physicians have come together to designate 2010 "The Year of the Lung. (qualityhealth.com)
  • Chest percussion works to loosen the mucus in your lungs . (dherbs.com)
  • If asthma is left untreated, it can eventually damage your lungs. (qualityhealth.com)
  • Even people without respiratory ailments may find that polluted air compromises their lung function and can lead to asthma or other long-term damage. (qualityhealth.com)
  • We recently found that patterned differentiation of airway smooth muscle drives branching morphogenesis of the epithelium in the mouse lung, but to date this mechanism is unexplored in other systems. (aiche.org)
  • Alveoli represent the fundamental unit for gas exchange - that is, breathing - and play additional critical roles, such as the production of pulmonary surfactant, a fluid that decreases surface tension and prevents lung collapse,' said Clair. (pnnl.gov)
  • You body needs oxygen to function and oxygen is obtained through gas exchange that takes place in the lungs. (healthstatus.com)
  • The greater the lung capacity the easier it is to provide your body and its organs with the vital oxygen it needs to live a happier, healthier life. (healthstatus.com)
  • Your lungs take air in to give your body oxygen, which the body needs to work. (baycare.org)
  • All terrestrial vertebrates rely on lungs to extract oxygen from the air and expel carbon dioxide generated in body tissues, but the structure of these lungs is not the same across the animal kingdom. (aiche.org)
  • Lungs allow us to breathe - to take in oxygen and release carbon dioxide. (pnnl.gov)
  • The lungs work nonstop to deliver oxygen to the bloodstream and expel carbon dioxide from the body. (dherbs.com)
  • Every cell in the body draws oxygen from the blood, so impaired lung function, which can result from any number of respiratory conditions or poor diet, means that the lungs cannot efficiently supply the body with the necessary amount of oxygen. (dherbs.com)
  • The efficiency of lung function and lung capacity determine how well they can deliver oxygen to the body and how quickly they can get rid of carbon dioxide. (dherbs.com)
  • When stale air becomes trapped in the lungs, it makes it difficult for them to absorb new oxygen. (dherbs.com)
  • Previous animal studies have shown cigarette-induced immune dysfunction, but these did not focus on lung-associated lymph nodes and did not reveal what types of immune cells were primarily affected. (thefreelibrary.com)
  • Human studies have yielded inconsistent results, probably because these studies haven't looked at the lung-associated lymph nodes, says George M. Shopp, also at lovelace. (thefreelibrary.com)
  • They found that cigarette exposure for 21 weeks or more significantly depressed B-cell function in the lung-associated lymph nodes, while exposure for more than 35 weeks affected immune cells in other lymphoid tissues such as the spleen. (thefreelibrary.com)
  • It's very important to note that lung capacity can be improved, but lung function cannot. (dherbs.com)
  • Six hours after infection, the researchers saw an increased bacterial load in the lungs and bronchial fluid of the mice, compared to mice of the same age whose mothers were not given antibiotics. (nutraingredients.com)
  • To fill these knowledge gaps, a cohort of PNNL scientists is using advanced mass spectrometry tools to perform a systematic characterization of normal lung development in mice and humans as part of the LungMAP Consortium funded by the National Heart Lung and Blood Institute. (pnnl.gov)
  • The diaphragm tightens and flattens, allowing you to suck air into your lungs. (dherbs.com)
  • Any activity that engages the abdominal muscles, especially the diaphragm, is beneficial for the lungs. (dherbs.com)
  • Singing is all about using the diaphragm to project sound, so sing in the shower, car, or in the garden to increase lung capacity. (dherbs.com)
  • October is National healthy lung month , a month that for many people causes multiple problems pertaining to their lungs. (healthstatus.com)
  • If you want to improve lung health then you need to improve lung capacity, and you'll find that the following exercises can help you do just that. (dherbs.com)
  • We found that smooth muscle is present in a mesh-like pattern around the lung epithelium and regulated by the same molecular signaling pathways as in the murine lung. (aiche.org)
  • Intestinal bacteria transferred at birth affect lung development, bacterial resistance and susceptibility to inflammatory conditions in newborns, according to a new mouse study. (nutraingredients.com)
  • Overall, said Kyle, the study provided a rare 'deep and comprehensive view of the lung lipidome during normal development. (pnnl.gov)
  • Asbestos workers who smoke increase their risk of developing lung cancer by 50-100 times. (encyclopedia.com)
  • This scarring may increase the risk of developing lung cancer. (encyclopedia.com)
  • Although scientists are yet to find a clear association between tuberculosis and lung cancer, evidences suggest that tuberculosis patients have a higher risk of developing lung cancer. (amazonaws.com)
  • Smoking remains the biggest risk to developing lung cancer, and is responsible for more than 85% of cases. (news-medical.net)
  • Using other types of tobacco including cigars, pipe tobacco, snuff or chewing tobacco also poses increased risks of developing lung cancer, mouth cancer and oesophageal cancer. (news-medical.net)
  • ETS, otherwise known as passive smoking or second-hand smoking, where smoke is inhaled from someone else's cigarette, pipe, or cigar, can increase the risk of developing lung cancer even though you are not smoking yourself. (news-medical.net)
  • The risk of developing lung cancer is proportional to the number of cigarettes smoked per day. (healthy.net)
  • If you stop smoking, within 15 years your risk of developing lung cancer will be roughly the same as a non-smoker. (medic8.com)
  • Smokers and former smokers have a ten- to fiftyfold greater risk of developing lung cancer. (technologyreview.com)
  • If someone stops smoking, their risk of developing lung cancer gets lower over time. (macmillan.org.uk)
  • Occupational exposure to diacetyl has been associated with severe respiratory impairment and obliterative bronchiolitis, a serious lung disease that is irreversible. (cdc.gov)
  • Read up on the latest in respiratory news with Lung Foundation Australia. (lungfoundation.com.au)
  • The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails . (wikipedia.org)
  • The lungs are part of the lower respiratory tract that begins at the trachea and branches into the bronchi and bronchioles , and which receive air breathed in via the conducting zone . (wikipedia.org)
  • White lung or white lung syndrome may refer to: Acute respiratory distress syndrome Asbestosis Pulmonary alveolar microlithiasis Silicosis White Lung, a Canadian punk rock group This disambiguation page lists articles associated with the title White lung. (wikipedia.org)
  • Farmer's Lung: Causes and Symptoms of Mold and Dust Induced Respiratory Illness" (PDF). (wikipedia.org)
  • Acute lung injury (ALI) comprises acute respiratory distress syndrome (ARDS), a grave and deadly form of acute lung injury, and other minor degrees of lung injuries. (tmrresearch.com)
  • It includes acute respiratory failure owing to progressive hypoxemia, diffuse bilateral pulmonary infiltration, and reduced lung compliance. (tmrresearch.com)
  • Black lung , also called Black-lung Disease , or Coal-workers' Pneumoconiosis , respiratory disorder, a type of pneumoconiosis caused by repeated inhalation of coal dust over a period of years. (britannica.com)
  • In addition to respiratory activities, the lungs perform other bodily functions. (britannica.com)
  • Healed lung tissue becomes a fibrous scar unable to perform respiratory duties. (britannica.com)
  • The lung is the main organ of the respiratory system. (healthcentral.com)
  • A general approach to immunocompromised patients with respiratory symptoms and the evaluation of interstitial lung disease in patients receiving chemotherapy are presented separately. (uptodate.com)
  • Patients typically suffer so much lung damage that they often go into respiratory failure, which is why Sarah needs a lung transplant to survive. (go.com)
  • CF may ultimately lead to extensive lung damage and respiratory failure. (memorialhermann.org)
  • People who suffer from respiratory issues like asthma and chronic obstructive pulmonary disease often have problems with their lung function and capacity. (wikihow.com)
  • Eventually, if simple black lung progresses to what's known as "complicated black lung" (or "progressive massive fibrosis"), it becomes more and more difficult to breathe-which can lead to respiratory or heart failure. (nolo.com)
  • Occupational respiratory disease is any lung condition you get at work. (familydoctor.org)
  • The lower respiratory tract includes the lungs, bronchi, and alveoli. (hopkinsmedicine.org)
  • The lungs are the center of the respiratory (breathing) system. (healthline.com)
  • The lungs are the main part of the respiratory system. (healthline.com)
  • Other parts of the respiratory system help your lungs to expand and contract as you breathe. (healthline.com)
  • If you have a respiratory illness, your lungs may make too much mucus. (healthline.com)
  • Lung function tests also provide a measure of the efficiency of the respiratory system (Evans, 1994). (everything2.com)
  • or bronchi: are the main airways connected to the upper respiratory system (nose/sinuses/mouth), which carry oxygen to the lungs. (bellaonline.com)
  • One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of neutrophils into the lung interstitium and alveolar space. (hindawi.com)
  • In contrast, bird breath travels tidally through part of the respiratory system, but in a one-way loop throughout most of the lung. (newswise.com)
  • NI Chest, Heart and Stroke is urging people to check their lungs for early signs of respiratory disease. (bbc.co.uk)
  • Some lung tumors make hormone-like chemicals. (webmd.com)
  • Lung tumors are a frequently treated disease at our center. (slideshare.net)
  • present in their paper " Modeling airflow using subject-specific 4DCT-based deformable volumetric lung models " a subject-specific modeling of lung tumors and adjacent tissues motions based on computational fluid dynamics (CFD). (hindawi.com)
  • Doctors know that smokers and former smokers are at much greater risk than the rest of the population, yet there's no safe way to screen them, and lung tumors are rarely discovered in early, more curable stages. (technologyreview.com)
  • The cells from the abnormal can't develop into a healthy lung tissue and spread quickly and form tumors. (bartleby.com)
  • Patients typically inhale the drug, yet find themselves chronically infected their whole lives, eventually needing a lung transplant. (msu.edu)
  • A lung transplant is an operation to remove and replace a diseased lung with a healthy human lung from a donor. (www.nhs.uk)
  • You also won't be considered for a lung transplant if you smoke. (www.nhs.uk)
  • It's possible for a person to receive a lung transplant from living donors (two living donors are usually required for one recipient). (www.nhs.uk)
  • During this type of lung transplant, the lower lobe of the right lung is removed from one donor, and the lower lobe of the left lung is removed from the other donor. (www.nhs.uk)
  • Read more about preparing for a lung transplant . (www.nhs.uk)
  • A lung transplant usually takes between four and 12 hours to complete, depending on the complexity of the operation. (www.nhs.uk)
  • Read more about how a lung transplant is performed . (www.nhs.uk)
  • A lung transplant is a major operation that may take at least three months to recover from. (www.nhs.uk)
  • Read more about recovering from a lung transplant . (www.nhs.uk)
  • A lung transplant is a complex type of surgery that carries a high risk of complications. (www.nhs.uk)
  • Read more about risks associated with a lung transplant . (www.nhs.uk)
  • The outlook for people who've had a lung transplant has improved in recent years and it's expected to continue improving. (www.nhs.uk)
  • For decades, heart and lung transplant surgeons have followed a strict directive: Get the donor organ into the recipient as soon as possible. (latimes.com)
  • We won't just transplant an organ," said Dr. Shaf Keshavjee, the senior author of the study and director of the Toronto Lung Transplant Program at Toronto General Hospital. (latimes.com)
  • In the United States, 1,786 people are on the waiting list for a lung transplant, according to the Department of Health and Human Services' Organ Procurement and Transplantation Network. (latimes.com)
  • About one-third of these patients wait at least three years for a suitable pair of donor lungs, and about 10% to 15% of people die before receiving a transplant. (latimes.com)
  • Researchers treated 23 sets of lungs that were impaired in some manner - and would have been rejected for transplant - with perfusion for four hours and transplanted 20 of them that looked viable after the treatment. (latimes.com)
  • There is still some discrepancy from the transplant community on whether this will really bring significant benefit," said Dr. Christian A. Bermudez, associate director of heart and lung transplantation at the University of Pittsburgh School of Medicine. (latimes.com)
  • Some people may develop popcorn lung after transplant surgery, but it may take months to years to develop. (medicalnewstoday.com)
  • Transplant surgeries may cause a condition called graft-versus-host disease, which occurs when the body rejects organ transplantation, particularly after lung, bone marrow , or stem cell transplants. (medicalnewstoday.com)
  • During a lung transplant, surgeons remove your diseased lung and then attach a donor lung to your airway and to the blood vessels that lead to and from your heart. (mayoclinic.org)
  • A lung transplant is a surgical procedure to replace a diseased or failing lung with a healthy lung, usually from a deceased donor. (mayoclinic.org)
  • A lung transplant is reserved for people who have tried other medications or treatments, but their conditions haven't sufficiently improved. (mayoclinic.org)
  • Depending on your medical condition, a lung transplant may involve replacing one of your lungs or both of them. (mayoclinic.org)
  • While a lung transplant is a major operation that can involve many complications, it can improve your health and quality of life. (mayoclinic.org)
  • When faced with a decision about having a lung transplant, know what to expect of the lung transplant process, the surgery itself, potential risks and follow-up care. (mayoclinic.org)
  • But when these measures no longer help or your lung function becomes life-threatening, your doctor might suggest a single-lung transplant or a double-lung transplant. (mayoclinic.org)
  • Some people with coronary artery disease may need a procedure to restore blood flow to a blocked or narrowed artery in the heart, in addition to a lung transplant. (mayoclinic.org)
  • In some cases, people with serious heart and lung conditions may need a heart-lung transplant. (mayoclinic.org)
  • A lung transplant isn't the right treatment for everyone. (mayoclinic.org)
  • Certain factors may mean you're not a good candidate for a lung transplant. (mayoclinic.org)
  • Complications associated with a lung transplant can sometimes be fatal. (mayoclinic.org)
  • The risk of rejection is highest soon after the lung transplant and is reduced over time. (mayoclinic.org)
  • Four of the eight workers were ill and put on lung transplant waiting lists. (cdc.gov)
  • The 10-year-old girl whose family successfully fought a rule preventing her from qualifying for adult lungs has woken up nine days after receiving a lung transplant from an adult donor. (go.com)
  • Sarah was dying of cystic fibrosis when her family brought the Under 12 Rule, a little-known organ transplant policy, to national attention after arguing that it had been pushing Sarah to the bottom of the adult lung transplant waiting list. (go.com)
  • On June 12 Sarah underwent a lung transplant with lungs from an adult donor. (go.com)
  • Today, lung transplants are performed under the auspices of the multidisciplinary Women's Guild Lung Institute, part of the Comprehensive Transplant Center. (cedars-sinai.edu)
  • Once an individual is deemed to be a good lung transplant candidate, he or she is listed with the United Network for Organ Sharing (UNOS). (cedars-sinai.edu)
  • People waiting for a transplant are assigned an organ on the basis of a lung allocation score. (cedars-sinai.edu)
  • This score is calculated using objective criteria that predict how serious their disease is and the probability of their getting benefit from a lung transplant. (cedars-sinai.edu)
  • Every lung transplant program in the country depends on the generosity of potential organ donors and their families. (cedars-sinai.edu)
  • In the case of a double lung transplant, the procedure is repeated for the second lung in the other side of the chest. (cedars-sinai.edu)
  • When lungs cease to function normally, whether from damage or disease, a lung transplant - a surgical procedure to replace one or both diseased lungs with a healthy lung(s), usually from a deceased donor - may be necessary. (memorialhermann.org)
  • The Memorial Hermann Lung Transplant program partners with the Center for Advanced Heart Failure at the Memorial Hermann Heart and Vascular Institute at Memorial Hermann-Texas Medical Center (TMC), a recognized national leader in the treatment of advanced cardiothoracic disease. (memorialhermann.org)
  • The multidisciplinary lung transplant team at the Transplant Center is led by affiliated pulmonary and critical care specialist Soma Jyothuyla, MD , and affiliated cardiothoracic and vascular surgeon Keshava Rajagopal, MD, PhD . Drs. Jyothula and Rajagopal are respectively medial and surgical directors of the Lung Transplant program at Memorial Hermann-Texas Medical Center and associate professors at McGovern Medical School at UTHealth in Houston. (memorialhermann.org)
  • The following are common diseases or conditions which may require a lung transplant. (memorialhermann.org)
  • A lung transplant may be an option, but only if the patient is healthy enough to withstand the procedure. (nolo.com)
  • The findings from NIOSH investigations in the microwave popcorn and flavorings manufacturing industries provided a basis for a 2004 NIOSH Alert: Preventing Lung Disease in Workers Who Use or Make Flavorings . (cdc.gov)
  • Read " Coffee Workers at Risk for Lung Disease " and " Diacetyl and Food Flavorings " on the NIOSH Science Blog and share your comments. (cdc.gov)
  • Asthma is a lung disease that makes breathing difficult for millions of Americans. (lung.org)
  • Make a difference by delivering research, education and advocacy to those impacted by lung disease. (lung.org)
  • Lung Foundation Australia is working to improve lung health and reduce the impact of lung disease for all Australians. (lungfoundation.com.au)
  • Show your support for the 7 million Australian men, women and children battling a debilitating and often fatal lung disease. (lungfoundation.com.au)
  • Anyone can get lung disease. (lungfoundation.com.au)
  • When you have a chronic lung disease , such as pulmonary fibrosis or chronic obstructive pulmonary disease (COPD), having enough oxygenated blood can be challenging. (lunginstitute.com)
  • For people with lung disease, lung function and lung capacity can diminish over time. (lunginstitute.com)
  • For many people with a chronic lung disease, shortness of breath presents many challenges. (lunginstitute.com)
  • Farmer's lung (not to be confused with silo-filler's disease) is a hypersensitivity pneumonitis induced by the inhalation of biologic dusts coming from hay dust or mold spores or any other agricultural products. (wikipedia.org)
  • Farmer's lung disease is permanent and cannot be reversed, therefore in order to prevent the onset of further stages, farmers should inform their doctor of their occupation and if they have mold in their work environment. (wikipedia.org)
  • The presence of diffuse lung disease in chronic cases. (wikipedia.org)
  • I started my post yesterday with my version of the famous quote from the film Casablanca: "I'm shocked, shocked to find an epidemic of black lung disease. (scienceblogs.com)
  • It was my reaction to the latest story by NPR's Howard Berkes about nearly 2,000 recently diagnosed cases of the most severe form of black lung disease. (scienceblogs.com)
  • The American Lung Association is the leading organization working to save lives by improving lung health and preventing lung disease, through research, education and advocacy. (idealist.org)
  • The disease gets its name from a distinctive blue-black marbling of the lung caused by accumulation of the dust. (britannica.com)
  • Georgius Agricola , a German mineralogist, first described lung disease in coal miners in the 16th century, and it is now widely recognized. (britannica.com)
  • They can sometimes cause serious lung infections if you have mold allergies, a lung condition such as chronic obstructive pulmonary disease (COPD), or a weak immune system -- your body's defense against germs. (webmd.com)
  • It's sometimes called pigeon breeder's disease or bird fancier's lung. (webmd.com)
  • Venoarterial extracorporeal membrane oxygenation (ECMO) is used primarily in the treatment of lung disease. (encyclopedia.com)
  • Both treatments can be instituted in the critical care unit when severe heart or lung disease is no longer treatable by less invasive conventional treatments such as pharmaceuticals, intra-aortic balloon pump (IABP), and mechanical ventilation with a respirator. (encyclopedia.com)
  • Continued research and design has allowed the heart-lung machine to become a standard of care in the treatment of heart and lung disease, while supporting other non-conventional treatments. (encyclopedia.com)
  • INDIAN stone crushers are at risk of developing serious lung disease, according to a study to be published later this month in the Indian Journal of Occupational Health. (newscientist.com)
  • Most had poor lung function or pneumoconiosis-a type of lung disease caused by inhaling dust. (newscientist.com)
  • Diagnosing the precise nature of your interstitial lung disease allows us to prescribe the most effective treatment plan. (massgeneral.org)
  • Surgical lung biopsy: Surgery used in some cases to diagnose the type of lung disease. (massgeneral.org)
  • Camus P. Interstitial lung disease from drugs, biologics, and radiation. (uptodate.com)
  • On Wednesday, January 30th the "We Were There" lecture series presented "Not Everything Is Better with Butter-flavoring: Popcorn Lung Disease and the Dangers of Diacetyl," at the Roybal Campus, Alexander D. Langmuir Auditorium . (cdc.gov)
  • In 2000, a physician reported that eight former microwave-popcorn factory workers had developed a rare and disabling lung disease, bronchiolitis obliterans. (cdc.gov)
  • Attendees heard a fascinating story of how disease detectives unraveled the mystery of popcorn-lung disease, and how we can protect workers from permanent lung damage caused by diacetyl in butter flavoring. (cdc.gov)
  • As one of only a few medical centers in Southern California with Medicare certification for lung transplants, Cedars-Sinai offers a high level of experience and expertise in the surgical treatment of lung disease. (cedars-sinai.edu)
  • Candidates for lung transplants have end-stage lung disease with a poor prognosis and have failed to respond to conventional medical therapy. (cedars-sinai.edu)
  • Learn what black lung disease is, how to get screening and a diagnosis, and how to file a claim for benefits under state workers' comp or federal law. (nolo.com)
  • Black lung is a serious, and sometimes fatal, disease caused inhaling coal dust. (nolo.com)
  • If you've developed black lung disease as a result of your work mining coal-or you're the surviving dependent of a miner who died from the condition-you may file a claim and get benefits through your state's workers' compensation system or a special federal black lung program. (nolo.com)
  • Black lung disease may sound like something out of the past. (nolo.com)
  • Also called coal workers' pneumoconiosis, black lung disease begins when the body's immune system tries to rid itself of small particles of coal dust lodged in the lungs. (nolo.com)
  • The name of the disease comes from the appearance of its sufferers' lungs, which develop dark spots and eventually turn black. (nolo.com)
  • Black lung disease can be stealthy. (nolo.com)
  • To confuse matters even more, people with black lung have a higher risk of developing chronic bronchitis or emphysema, and the disease often appears alongside silicosis (a similar lung disease caused by inhaling silica dust). (nolo.com)
  • Historically, it took at least 10 or 20 years of exposure to develop black lung disease. (nolo.com)
  • Early detection is particularly important for black lung, because the only way to keep the disease from progressing is to stop the exposure to coal dust. (nolo.com)
  • As a surge of black lung disease scars miners' lungs at younger ages than ever, Robinson worries not only about cuts to his benefits, but that younger miners won't get any coverage. (yahoo.com)
  • I just feel that Mitch McConnell has let the citizens of Kentucky down, especially the miners," said Patty Amburgey, whose husband, Crawford, died of black lung disease at age 62 in 2007. (yahoo.com)
  • In less than four years, Crum has seen 200 miners diagnosed with a severe form of black lung disease, called pulmonary massive fibrosis. (yahoo.com)
  • His findings were published by the Centers for Disease Control and Prevention in a December 2016 report that showed a shockingly high level of severe black lung cases at his clinic. (yahoo.com)
  • Nontuberculous mycobacteria (NTM) cause nontuberculous mycobacterial (NTM) lung disease. (medicinenet.com)
  • Kevin Krause, Dallas News , "Pharmacy owner whose drugs led to doped racehorses admits to peddling unsafe equine drugs," 5 July 2019 The fungus can cause disease in people who have weakened immune systems, damaged lungs or have allergies, the website states. (merriam-webster.com)
  • Coal workers' pneumoconiosis, also known as Black Lung Disease. (familydoctor.org)
  • A federal advisory panel backed the approval of a proposed lung drug that would be marketed by Forest Laboratories Inc. to treat chronic obstructive pulmonary disease. (wsj.com)
  • Some types may lead to, or be a sign of, lung disease. (healthline.com)
  • Results indicate whether dyspnoea is due to heart or lung disease. (everything2.com)
  • By supporting the American Lung Association you are helping us fight for all those affected by lung disease. (convio.net)
  • Seeing an average of 200 patients a year, we are experts in managing conditions such as interstitial lung disease (ILD), surfactant mutations, lung development disorders and lymphatic disorders. (cincinnatichildrens.org)
  • Under the direction of Christopher Towe MD , the program includes some of the nation's most respected experts in lung disease. (cincinnatichildrens.org)
  • Kuwaiti children with rare lung disease find help at Cincinnati Children's. (cincinnatichildrens.org)
  • We have compiled a list of support and information resources to help you better understand your child's rare lung disease. (cincinnatichildrens.org)
  • Full-time faculty of the Division of Pulmonary Medicine , led by Drs. Tammy Clark Ojo and Kevin Chan, work in partnership with Scleroderma Program faculty in evaluating and treating scleroderma lung disease. (umich.edu)
  • Thousands of people in Northern Ireland are suffering from a serious lung disease without knowing it, a medical charity has warned. (bbc.co.uk)
  • Medical terms related to the lung often begin with pulmo- , from the Latin pulmonarius (of the lungs) as in pulmonology , or with pneumo- (from Greek πνεύμων "lung") as in pneumonia . (wikipedia.org)
  • Other contributory factors which are likely to lead to acute lung injury comprise pneumonia, sepsis, major trauma, and inhalation of noxious fumes. (tmrresearch.com)
  • Popcorn lung can be mistaken for a different condition called bronchiolitis obliterans organizing pneumonia (BOOP). (medicalnewstoday.com)
  • Other, less common forms of lung injury include organizing pneumonia and hypersensitivity pneumonitis [ 3 ]. (uptodate.com)
  • Cystic fibrosis (CF) is a genetic (inherited) disorder in which a defective gene causes a thick, sticky buildup of mucus in the lungs (as well as other organs), causing wheezing or shortness of breath, chronic cough and frequent lung infections, such as bronchitis or pneumonia. (memorialhermann.org)
  • Learn about topics such as How to Strengthen Your Lungs After Having Pneumonia , How to Increase Your Lung Capacity , How to Heal the Lungs Naturally , and more with our helpful step-by-step instructions with photos and videos. (wikihow.com)
  • Inflammation from toxic substances, such as tobacco smoke, asbestos, and environmental dusts, can also produce significant damage to the lung. (britannica.com)
  • The perfusion technique essentially repairs damage caused by swelling or inflammation in the lung, Dark said. (latimes.com)
  • The Lung Biology laboratories seek to identify the novel mechanisms of lung inflammation and host defense, and explore how these mechanisms may be exploited to develop novel treatment and prevention strategies. (lsu.edu)
  • The Lung Biology group in the Schol of Veterinary Medicine (SVM) uses vertically integrated experimental cutting edge methodologies aimed at dissecting lung inflammation and host defense with expertise ranging from cell culture to animal (in vivo) models. (lsu.edu)
  • Popcorn lung is a rare condition that causes airway scarring due to inflammation and eventually lung damage. (medicalnewstoday.com)
  • Lung biopsies in patients with long-term exposure usually demonstrate chronic interstitial inflammation and poorly formed nonnecrotizing granulomas. (medscape.com)
  • Lung involvement includes inflammation (potentially treatable), scarring (potentially preventable) and blood vessel injury leading to pulmonary hypertension (many FDA approved agents now available). (umich.edu)
  • After investigating numerous possible sources, researchers ultimately determined the cause of lung damage: a vapor from butter flavoring added to the popcorn. (cdc.gov)
  • Vitamin E acetate has been found in product samples tested by FDA and state laboratories and in patient lung fluid samples tested by CDC from geographically diverse states. (cdc.gov)
  • Vitamin E acetate has not been found in the lung fluid of people that do not have EVALI. (cdc.gov)
  • Vitamin E acetate was identified in bronchoalveolar lavage (BAL) fluid samples (fluid samples collected from the lungs) from 48 of the 51 EVALI patients, but not in the BAL fluid from the healthy comparison group. (cdc.gov)
  • When the lungs are formed the fetus is held in the fluid -filled amniotic sac and so they do not function to breathe. (wikipedia.org)
  • This causes fluid, protein, and cells to accumulate in the alveolar wall which slows blood-gas interchange and compromises the function of the lung. (wikipedia.org)
  • Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. (tmrresearch.com)
  • thoracentesis (samples fluid that has built up around the lungs). (familydoctor.org)
  • High levels might cause your lungs to fill with fluid. (webmd.com)
  • He needed 17 tubes to help remove fluid buildup and inflate his lungs as well as a tracheotomy to help him breathe and tubes for feeding. (nypost.com)
  • correlates fluid redistribution and reabsorption to changes in regional lung function by image matching. (hindawi.com)
  • They take samples (biopsies) of the lining of the lungs (the pleura) and can remove fluid that may have collected there. (macmillan.org.uk)
  • Your lungs make a fluid called surfactant to help them stay open. (healthline.com)
  • [1] The left lung shares space with the heart, and has an indentation in its border called the cardiac notch of the left lung to accommodate this. (wikipedia.org)
  • the left lung, which is slightly smaller because of the asymmetrical placement of the heart, has two lobes. (britannica.com)
  • I had a CT of my abdomen and it showed an accidental finding of a 10mm non calcified nodule in my left lung. (medhelp.org)
  • They found a 11mm nodule on my left lung. (medhelp.org)
  • The left lung has only two lobes to make room for your heart. (healthline.com)
  • See some of the current topics American Lung Association funded researchers are investigating. (lung.org)
  • Researchers say that there is good evidence that occasional marijuana use can cause an increase in lung airflow rates and lung volume. (medicalnewstoday.com)
  • In a study published Wednesday in the New England Journal of Medicine , researchers said the number of donor lungs and successful transplants may be dramatically increased by treating the organs on a perfusion machine for several hours before transplantation. (latimes.com)
  • We hope that this approach will help researchers explore different aspects of chronic lung infection microbiology while reducing reliance on animal experiments. (warwick.ac.uk)
  • al.com , "America's military accomplished an amazing feat 100 years ago -- driving across country," 7 July 2019 Medical researchers have reported that sildenafil can boost performance in racehorses, which are prone to lung bleeding and edema after races. (merriam-webster.com)
  • The researchers took CT scans of the entire lung labyrinth and used two different supercomputers to simulate airflow patterns at the highest resolution. (newswise.com)
  • Acute lung injury, a common condition characterized by acute severe hypoxia without evidence of hydrostatic pulmonary edema, remains a key source of mortality and morbidity in critically ill patients. (tmrresearch.com)
  • It has been observed that even in patients who survive acute lung injury, the quality of life is adversely affected in the long term. (tmrresearch.com)
  • The hydrostatic pressure however remains unaffected in the patients suffering with acute lung injury (ALI). (tmrresearch.com)
  • Surgery outcomes were compared with 116 patients who received conventional donor lungs. (latimes.com)
  • After 72 hours, 15% of the patients who received treated lungs suffered primary graft dysfunction, a potentially fatal complication, compared with 30% of the patients in the control group. (latimes.com)
  • Use of this treatment in the emergency room is not limited to patients suffering heart or lung failure. (encyclopedia.com)
  • Being that this technology serves both adult and pediatric patients specialized children¸s hospitals may provide treatment with the heart-lung machine for Venoarterial ECMO. (encyclopedia.com)
  • Most patients wait an average of 3 to 6 months for a donor lung, although there are some factors that may prolong the time until a donor lung becomes available. (cedars-sinai.edu)
  • The screens have a high rate of false positives, which means that some patients are subjected to lung biopsies and other harrowing and risky procedures that may turn out to be unnecessary. (technologyreview.com)
  • Slowly breathe in, and expand your lungs to the maximum capacity. (lunginstitute.com)
  • The radioactive particles in radon damage your lungs when you breathe them in or swallow them. (webmd.com)
  • This can trigger or worsen asthma and other lung and heart issues if you breathe it. (webmd.com)
  • Luckily, there are things you can do at home to improve your lung function, and therefore your ability to breathe. (wikihow.com)
  • Other than reducing exposure to coal dust, treatment options for black lung are limited and generally focused on helping the patient breathe. (nolo.com)
  • Many, including Robinson, struggle to breathe as their lungs are slowly stifled by tiny dust and particles trapped there. (yahoo.com)
  • The lungs are the parts of the body that we use to breathe. (macmillan.org.uk)
  • Your lungs are specially designed to exchange these gases every time you breathe in and out. (healthline.com)
  • Breathe easier by learning all you can about asthma and how it affects your lungs. (bellaonline.com)
  • Stage 2B also describes a tumor that has not spread to lymph nodes, but has spread to other tissues, a main airway, or caused the lung to collapse. (news-medical.net)
  • Chemical damage to the lung tissues can cause popcorn lung, as can a few other factors. (medicalnewstoday.com)
  • The vessel-related constraint is integrated into the registration to correct mismatches of small lung vessels and their surrounding tissues. (hindawi.com)
  • Lung transplants aren't carried out frequently in the UK. (www.nhs.uk)
  • In England, during 2013-14, 198 lung transplants were carried out. (www.nhs.uk)
  • The demand for lung transplants is far greater than the available supply of donated lungs. (www.nhs.uk)
  • However, lung transplants from living donors are currently rare in the UK. (www.nhs.uk)
  • Most people who receive lung transplants from living donors have cystic fibrosis and are close relatives of the donors. (www.nhs.uk)
  • symptom s at the time of diagnosis often reflect invasion of the lymph node s, pleura, the other lung or the metastasis to other organs . (everything2.com)
  • However, it can be difficult to distinguish between a tumor and a lung abscess, meaning an X-ray is not a definitive test. (news-medical.net)
  • A donor is usually a person who's died, but in rare cases a section of lung can be taken from a living donor. (www.nhs.uk)
  • In some situations, the lungs may be transplanted along with a donor heart. (mayoclinic.org)
  • Even with the best possible match between you and the donor, your immune system will try to attack and reject your new lung or lungs. (mayoclinic.org)
  • The native diseased lung or lungs are removed from the recipient while the donor lung is being recovered. (cedars-sinai.edu)
  • That poses a challenge because lungs are easily damaged from injury or in the final stages of terminal illness. (latimes.com)
  • This test can help diagnose or rule out a pulmonary embolism, or a blood clot in your lung. (nih.gov)
  • Your lung specialist may then schedule additional meetings and/or testing to diagnose your specific disorder and formulate a treatment plan. (massgeneral.org)
  • The following tests may be used to diagnose lung metastases. (cancer.ca)
  • A lung scan is an imaging test to look at your lungs and help diagnose certain lung problems. (hopkinsmedicine.org)
  • But your healthcare provider may also use the scan to help diagnose other lung conditions. (hopkinsmedicine.org)
  • With marijuana use increasing and large numbers of people who have been and continue to be exposed, knowing whether it causes lasting damage to lung function is important for public-health messaging and medical use of marijuana. (medicalnewstoday.com)
  • Nontuberculous mycobacteria (NTM), most commonly, M. avium complex or MAC, is a mycobacteria that causes lung infections and. (medicinenet.com)
  • Just brushing your teeth with toothpaste that has triclosan won't help to treat lung infections though, Maiden said. (msu.edu)
  • The lungs are frequently involved in infections and injuries. (britannica.com)
  • Some infections can destroy vast areas of a lung, rendering it useless. (britannica.com)
  • Certain lung infections can cause it as well. (medicalnewstoday.com)
  • Chronic lung infections are life-limiting or even life-threatening. (warwick.ac.uk)
  • We are excited by our recent collaborative funding from the National Biofilms Innovation Centre, which will enable us to work together to assess a novel method to detect how well antibiotics penetrate biofilms in chronic lung infections. (warwick.ac.uk)
  • The anti-rejection drugs suppress your immune system, making your body more vulnerable to infections, particularly in your lungs. (mayoclinic.org)
  • SI.com , "Farewell Alberto Moreno: The Last Remnant of Liverpool's Banter Era," 2 July 2019 Staph infections are caused by germs commonly found on the skin or in the nose and can turn deadly if spread to the bloodstream, joints, bones, lungs or heart, according to the Mayo Clinic. (merriam-webster.com)
  • CDC, the U.S. Food and Drug Administration (FDA), state and local health departments, and other clinical and public health partners are investigating a national outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). (cdc.gov)
  • The FP-1201-lyo treatment for acute lung injury is now in the 3rd phase of clinical trials and is anticipated to obtain European marketing authorization in the near future. (tmrresearch.com)
  • It has been claimed that one of the operating principles of HFCWO vests is creating 'airflow bias' in the lungs, but valid clinical evidence supporting that claim is lacking," he added. (cysticfibrosisnewstoday.com)
  • A randomized clinical trial was conducted to study the effects of supplemental, carotenoid-rich vegetable juice (V-8) on lung function macrophage levels of carotenoids and in moderating ozone-induced lung damage. (nih.gov)
  • when combined with culture medium tailored to reflect the unique chemistry of lung secretions characteristic of specific infection contexts, this model allows the culture of microbes in environments with enhanced clinical validity when compared with standard surface-attached biofilm platforms or acute animal models. (warwick.ac.uk)
  • The pathogenesis and clinical aspects of bleomycin-induced lung injury will be reviewed here. (uptodate.com)
  • It results in a thick mucus in the lungs, which becomes a magnet for bacteria. (msu.edu)
  • He continues that even at daily usage levels of one joint per day over seven years, people were not seeming to have any degradation of lung capacity or function. (medicalnewstoday.com)
  • Keeping a positive attitude and having self-confidence can help people improve their mood and outlook, which can help you stay motivated on your path to increasing your lung capacity. (lunginstitute.com)
  • The lungs also provide airflow that makes vocal sounds including human speech possible. (wikipedia.org)
  • None of the vest groups showed statistically significant increased airflow in the lungs. (cysticfibrosisnewstoday.com)
  • Based on the concept of increased cephalad airflow bias in the lungs during use of HFCWO devices, one might expect that the expiratory peak flow [PEF] should be increased," the study noted. (cysticfibrosisnewstoday.com)
  • Different types of airflow patterns in animal lungs. (newswise.com)
  • Monitor lizards (below) have a net-unidirectional airflow pattern where air moves to-and-fro, but more air moves forward or backward over the whole ventilatory cycle in each parts of the lung. (newswise.com)
  • In 2014 , Cieri and colleagues analyzed one section of the lung that had primarily one-way airflow. (newswise.com)
  • Oxidative damage to the lung appears important in the pathophysiology of lung injury, and antioxidants may ameliorate the process [ 4,8 ]. (uptodate.com)
  • Pulmonary function was assessed according to the American Thoracic Society's (ATS) guidelines for baseline lung function parameters: peak expiratory flow (PEF) and tidal volume (TV) were measured in addition to FVC, FEV1, and forced expiratory flow (FEF25%-75%) - a measure taken between the start and finish of FVC. (cysticfibrosisnewstoday.com)