One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Preparations of Cassia senna and C. angustifolia (see SENNA PLANT). They contain sennosides, which are anthraquinone type CATHARTICS and are used in many different preparations as laxatives.
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
The application of pathology to questions of law.
Oil obtained from seeds of Ricinus communis that is used as a cathartic and as a plasticizer.
A family of hexahydropyridines.

Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. (1/165)

The antihyperalgesic properties of the opiate antidiarrheal agent loperamide (ADL 2-1294) were investigated in a variety of inflammatory pain models in rodents. Loperamide exhibited potent affinity and selectivity for the cloned micro (Ki = 3 nM) compared with the delta (Ki = 48 nM) and kappa (Ki = 1156 nM) human opioid receptors. Loperamide potently stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding (EC50 = 56 nM), and inhibited forskolin-stimulated cAMP accumulation (IC50 = 25 nM) in Chinese hamster ovary cells transfected with the human mu opioid receptor. The injection of 0.3 mg of loperamide into the intra-articular space of the inflamed rat knee joint resulted in potent antinociception to knee compression that was antagonized by naloxone, whereas injection into the contralateral knee joint or via the i.m. route failed to inhibit compression-induced changes in blood pressure. Loperamide potently inhibited late-phase formalin-induced flinching after intrapaw injection (A50 = 6 microgram) but was ineffective against early-phase flinching or after injection into the paw contralateral to the formalin-treated paw. Local injection of loperamide also produced antinociception against Freund's adjuvant- (ED50 = 21 microgram) or tape stripping- (ED50 = 71 microgram) induced hyperalgesia as demonstrated by increased paw pressure thresholds in the inflamed paw. In all animal models examined, the potency of loperamide after local administration was comparable to or better than that of morphine. Loperamide has potential therapeutic use as a peripherally selective opiate antihyperalgesic agent that lacks many of the side effects generally associated with administration of centrally acting opiates.  (+info)

Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models. (2/165)

The effects of a 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 (6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate) on experimental diarrhea and on intestinal fluid secretion stimulated by cholera toxin were examined and compared with those of ramosetron and loperamide. KB-R6933 and ramosetron (0.03-1 mg/kg, p.o.) inhibited the diarrhea induced by 5-HT, but not that by castor oil or prostaglandin E2 (PGE2), in mice. Loperamide significantly inhibited the diarrhea induced by 5-HT, castor oil and PGE2. All drugs tested inhibited the diarrhea induced by restraint stress and the intestinal fluid secretion stimulated by cholera toxin in rats. The results suggest the possibility that KB-R6933 may have clinical efficacy in the treatment of diarrhea.  (+info)

Oral rehydration therapy plus loperamide versus loperamide alone in the treatment of traveler's diarrhea. (3/165)

Eighty United States students in Mexico received either loperamide (an initial dose of 4 mg, followed by 2 mg after passage of each unformed stool, up to 8 mg/d; 40 patients) or loperamide (at the same dosage schedule) plus an oral rehydration therapy (ORT) preparation (500 mL initially, followed by 250 mL after each subsequently passed unformed stool, up to 1,000 mL per 24 hours; 40 patients). The ORT preparation was a modification of the World Health Organization-recommended solution, adjusted to a sodium concentration of 60 mEq/L. All treatments were given for 48 hours. The study demonstrated equivalent clinical responses with regard to diminishment of diarrhea or subjective findings such as abdominal pain/cramps, headache, dry mouth, dizziness, or thirst. Stool number (by form) and specific gravity of urine postenrollment were similar in the groups. Administration of loperamide plus ORT for the management of traveler's diarrhea, in cases in which subjects were encouraged to drink ad libitum, offered no benefit over administration of loperamide alone.  (+info)

Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment. (4/165)

BACKGROUND: Diarrhea is one of the most disturbing effects of chemotherapy, affecting quality of life on the one hand and limiting applicable doses on the other. Irinotecan (CPT-11) and 5-fluorouracil (5-FU) are associated with an elevated risk of developing severe diarrhea. Standard therapy consists of high-dose loperamide, but is associated with frequent failure. Other therapeutic regimens are still experimental. Endoscopic examination of a patient with severe loperamide-resistant diarrhea after CPT-11 chemotherapy revealed an inflammation of the ileo-coecal region. Oral therapy with the topical corticosteroid budesonide was immediately effective. This led to a phase I study of budesonide in CPT-11- and 5-FU-induced and loperamide-refractory diarrhea. PATIENTS AND METHODS: Fourteen patients with CPT-11- and seven patients with 5-FU-induced grade 3-4 (NCI/WHO) diarrhea and loperamide failure were enrolled in this study. All patients had metastatic colorectal cancer. RESULTS: In 86% of the CPT-11- and 57% of the 5-FU-treated patients with grade 3-4 diarrhea and loperamide failure, treatment with budesonide resulted in a reduction of diarrhea severity by at least two grades. CONCLUSIONS: The orally administered topical active steroid budesonide is highly effective in the therapy of loperamide-refractory chemotherapy (CPT-11 or 5-FU)-induced diarrhea.  (+info)

Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet. (5/165)

METHODS: The effects of 4 days of oral administration of different doses of two drugs, an enkephalinase inhibitor (the antisecretory agent, racecadotril) and a mu-receptor agonist (loperamide), on intestinal growth of a bacterial nonpathogenic strain (Escherichia coli E 404) and on the central nervous system (CNS) were compared in newborn gnotobiotic piglets. RESULTS: The E. coli content of the proximal jejunum (segment S1) and the E. coli ratio of stomach:segment S1 were similar in the racecadotril (20 mg/kg b.d., n = 5) and control groups. In contrast, in the loperamide group (1 mg/kg b.d., n = 4), the E. coli content of segment S1 and the E. coli ratio stomach:S1 were both significantly higher than with racecadotril or control (P = 0.04 and 0.005, respectively, for E. coli content; P = 0.05 and 0.03, respectively, for stomach:S1). There were no clinical signs of neurotoxicity and no deaths with racecadotril given orally at a high dose of 130 mg/kg b.d. (n = 5)--nearly 60 times the paediatric dosage. In contrast, an equivalent high dose of loperamide (5 mg/kg b.d.) resulted in death in three out of four piglets. CONCLUSIONS: In contrast to loperamide, racecadotril did not induce bacterial overgrowth and did not produce central neurotoxicity.  (+info)

Comparison of racecadotril and loperamide in adults with acute diarrhoea. (6/165)

METHODS: A multicentre, randomized, double-blind, double-placebo, parallel-group study was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg three times daily) and loperamide (2 mg after each diarrhoeic stool) in 157 adults with acute diarrhoea. Patients were treated for 7 days or until recovery, if this took place earlier. RESULTS: Both groups of patients passed similar numbers (mean +/- S.E.M.) of stools before recovery (3.5 +/- 0.5 for racecadotril vs. 2.9 +/- 0.4 for loperamide), and the duration of diarrhoea (mean +/- S.E.M.) was similar in both groups (14.9 +/- 2.0 h for racecadotril and 13.7 +/- 2.2 h for loperamide). Both treatments reduced the incidence of associated symptoms and signs during the study, and both were similarly well tolerated. However, more patients on loperamide reported rebound constipation during treatment (18.7% vs. 9.8% with racecadotril). CONCLUSIONS: The enkephalinase inhibitor, racecadotril, and the intestinal transit inhibitor, loperamide, were similarly and rapidly effective in resolving the symptoms and associated signs of diarrhoea.  (+info)

Comparison of racecadotril and loperamide in children with acute diarrhoea. (7/165)

METHODS: A multicentre, parallel-group, double-blind, double-placebo study was carried out to compare the efficacy, tolerability, and safety of racecadotril and loperamide in children aged 2 to 10 years who were suffering from acute diarrhoea. Patients received racecadotril (1.5 mg/kg) or loperamide (0.03 mg/kg) three times daily plus matching placebo until recovery. Fifty-two children received racecadotril and 50 loperamide. RESULTS: Patients on racecadotril passed a mean (+/- S.E.M.) of 2.7 +/- 0.4 stools before recovery compared with 2.1 +/- 0.4 stools for loperamide. The duration of diarrhoea was similar with both treatments. The incidence of adverse events was lower with racecadotril than with loperamide (11.5% vs. 22%), and significantly more patients on loperamide suffered from constipation (58% vs. 36.5%; P = 0.03). Moreover, significantly more children receiving loperamide required concomitant medication during the study (38% v 19.2%; P = 0.047). Measurement of abdominal circumference at the final consultation, 6 days after entry to the study, revealed no significant differences between treatments. CONCLUSIONS: Racecadotril and loperamide were equally effective in treating acute diarrhoea in these children, and racecadotril had a superior tolerability and safety profile.  (+info)

Sodium channel blockers and uridine triphosphate: effects on nasal potential difference in cystic fibrosis mice. (8/165)

Sodium channel inhibitors block the enhanced Na+ reabsorption in cystic fibrosis (CF). Extracellular nucleotides facilitate Cl- secretion via Ca2+ gated Cl- channels. A combination of these effects may produce less viscid secretions in CF which are easier to expectorate. This study examined the effects of combining sodium channel blockers with uridine triphosphate (UTP) on nasal membrane potential difference (PD) in CF insertional null mutant mice (cftr(tm1HGU)), deltaF508 homozygous mice (cftr(tm1Cam)) and matched control animals. Median basal PD in the insertional CF mice and deltaF508 CF mice were -28 and -34 mV respectively. These values were significantly different to the control animals (-20 mV). Amiloride and loperamide reduced the PD in cftr(tm1HGU) CF mice (deltaPD 13 mV & 15 mV respectively) suggesting Na+ blockade. The subsequent addition of UTP in a chloride-free vehicle increased the PD (deltaPD -8- -12.5 mV). DeltaF508 mice showed significantly greater responses compared with CF insertional null mutant mice (p<0.05). The action of UTP was brief and not prolonged by the addition alpha-beta-methylene-adenosine 5' diphosphate. Suramin, a competitive antagonist of P2 purinoceptors blocked the action of UTP. In conclusion, this study demonstrated dose dependant nasal membrane potential changes in differences mice with uridine triphosphate in the presence of sodium channel blockers suggestive of chloride secretion. More stable analogues of uridine triphosphate in combination with long acting sodium channel blockers such as loperamide may have therapeutic potential in cystic fibrosis.  (+info)

There are several types of diarrhea, including:

1. Acute diarrhea: This type of diarrhea is short-term and usually resolves on its own within a few days. It can be caused by a viral or bacterial infection, food poisoning, or medication side effects.
2. Chronic diarrhea: This type of diarrhea persists for more than 4 weeks and can be caused by a variety of conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), or celiac disease.
3. Diarrhea-predominant IBS: This type of diarrhea is characterized by frequent, loose stools and abdominal pain or discomfort. It can be caused by a variety of factors, including stress, hormonal changes, and certain foods.
4. Infectious diarrhea: This type of diarrhea is caused by a bacterial, viral, or parasitic infection and can be spread through contaminated food and water, close contact with an infected person, or by consuming contaminated food.

Symptoms of diarrhea may include:

* Frequent, loose, and watery stools
* Abdominal cramps and pain
* Bloating and gas
* Nausea and vomiting
* Fever and chills
* Headache
* Fatigue and weakness

Diagnosis of diarrhea is typically made through a physical examination, medical history, and laboratory tests to rule out other potential causes of the symptoms. Treatment for diarrhea depends on the underlying cause and may include antibiotics, anti-diarrheal medications, fluid replacement, and dietary changes. In severe cases, hospitalization may be necessary to monitor and treat any complications.

Prevention of diarrhea includes:

* Practicing good hygiene, such as washing hands frequently and thoroughly, especially after using the bathroom or before preparing food
* Avoiding close contact with people who are sick
* Properly storing and cooking food to prevent contamination
* Drinking safe water and avoiding contaminated water sources
* Avoiding raw or undercooked meat, poultry, and seafood
* Getting vaccinated against infections that can cause diarrhea

Complications of diarrhea can include:

* Dehydration: Diarrhea can lead to a loss of fluids and electrolytes, which can cause dehydration. Severe dehydration can be life-threatening and requires immediate medical attention.
* Electrolyte imbalance: Diarrhea can also cause an imbalance of electrolytes in the body, which can lead to serious complications.
* Inflammation of the intestines: Prolonged diarrhea can cause inflammation of the intestines, which can lead to abdominal pain and other complications.
* Infections: Diarrhea can be a symptom of an infection, such as a bacterial or viral infection. If left untreated, these infections can lead to serious complications.
* Malnutrition: Prolonged diarrhea can lead to malnutrition and weight loss, which can have long-term effects on health and development.

Treatment of diarrhea will depend on the underlying cause, but may include:

* Fluid replacement: Drinking plenty of fluids to prevent dehydration and replace lost electrolytes.
* Anti-diarrheal medications: Over-the-counter or prescription medications to slow down bowel movements and reduce diarrhea.
* Antibiotics: If the diarrhea is caused by a bacterial infection, antibiotics may be prescribed to treat the infection.
* Rest: Getting plenty of rest to allow the body to recover from the illness.
* Dietary changes: Avoiding certain foods or making dietary changes to help manage symptoms and prevent future episodes of diarrhea.

It is important to seek medical attention if you experience any of the following:

* Severe diarrhea that lasts for more than 3 days
* Diarrhea that is accompanied by fever, blood in the stool, or abdominal pain
* Diarrhea that is severe enough to cause dehydration or electrolyte imbalances
* Diarrhea that is not responding to treatment

Prevention of diarrhea includes:

* Good hand hygiene: Washing your hands frequently, especially after using the bathroom or before preparing food.
* Safe food handling: Cooking and storing food properly to prevent contamination.
* Avoiding close contact with people who are sick.
* Getting vaccinated against infections that can cause diarrhea, such as rotavirus.

Overall, while diarrhea can be uncomfortable and disruptive, it is usually a minor illness that can be treated at home with over-the-counter medications and plenty of fluids. However, if you experience severe or persistent diarrhea, it is important to seek medical attention to rule out any underlying conditions that may require more formal treatment.

... is not recommended in the United Kingdom for use during pregnancy or by nursing mothers. In the U.S., loperamide is ... Loperamide can be present in breast milk, and is not recommended for breast-feeding mothers. Loperamide is a substrate of P- ... Loperamide has typically been deemed to have a relatively low risk of misuse. In 2012, no reports of loperamide abuse were made ... Loperamide is often compared to diphenoxylate. Studies suggest that loperamide is more effective and has lower neural side ...
"Loperamide Hydrochloride". The American Society of Health-System Pharmacists. Retrieved Aug 25, 2015. "Acetaminophen". The ...
Loperamide counters diarrhea. Antacids counter heartburn or indigestion. Simethicone counters flatulence.[citation needed] ...
loperamide), antidepressants (ex. TCA, SSRI, SNRI) as well as others (ex. ketamine, clonidine, gabapentin). In addition, ...
Diarrhea was treatable with loperamide. Lack of nephrotoxicity and low urinary excretion supported use of drug without ...
Loperamide (Imodium) and bezitramide are analogs. Like loperamide, it has a methadone-like structure and a piperidine moiety. ... it appears to be less efficacious and have more adverse effects when compared with loperamide or codeine. "US label: ...
Examples include diphenoxylate, loperamide, and eluxadoline. Propulsive v t e (Articles with short description, Short ...
Loperamide (Imodium AD) an anti-diarrheal agent. Pepto Bismol tablets, to settle upset stomachs, treat diarrhea, and heartburn ...
Korey A, Zilm DH, Sellers EM (May 1980). "Dependence liability of two antidiarrheals, nufenoxole and loperamide". Clinical ... in a similar manner to loperamide and diphenoxylate. While it is able to activate μ-opioid receptors, it fails to cross the ...
A double-blind, controlled clinical trial versus loperamide. », Scand J Gastroenterol., 1993, 28, p. 352-4 Quach T.T., Rose C ...
Cottrell, J.; Koenig, K.; Perfekt, R.; Hofmann, R.; For the Loperamide-Simethicone Acute Diarrhoea Study Team (2015). " ... "Comparison of Two Forms of Loperamide-Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute ...
Active substance: loperamide) Motilium (against flatulence and bowel impairments. Active substance: domperidone) Reminyl ( ... loperamide) Haldol (haloperidol) Ergamisol (levamisole) Daktarin (miconazole) Vermox (mebendazole) Nizoral (ketoconazole) ( ...
Loperamide is a peripherally selective opioid available without a prescription used to suppress diarrhea. The ability to ... As such, it can be considered the antithesis of loperamide.) Naloxegol (Naloxegol is only peripherally active as it does not ... As such, it can be considered the antitheses of loperamide.) Froehde reagent Opiate comparison Opioid epidemic Opioid tapering ... Opioid drugs include partial agonists, like the anti-diarrhea drug loperamide and antagonists like naloxegol for opioid-induced ...
It may also be caused by the use of loperamide. Abdominal pain Abdominal bloating Abdominal tenderness Fever Tachycardia (rapid ...
These include:[citation needed] Anti-diarrheal medicine (e.g. loperamide, codeine) Vitamin, mineral supplements and L-glutamine ... Medications used may include antibiotics, antacids, loperamide, teduglutide, and growth hormone. Different types of surgery, ...
Loperamide may help decrease the number of bowel movements but is not recommended in those with severe disease. About 1.7 to 5 ... Medications such as loperamide (Imodium) and bismuth subsalicylate may be beneficial; however they may be contraindicated in ... Anti-motility agents like loperamide are also effective at reducing the number of stools but not the duration of disease. These ... It has better tolerability than loperamide, as it causes less constipation and flatulence. However, it has little benefit in ...
Doctors usually do not recommend antidiarrheal medications (e.g., Loperamide) for gastroenteritis because they tend to prolong ...
Bismuth subsalicylate may help with the symptoms; however, medications that slow the bowels such as loperamide are not ... Antidiarrheal drugs (such as diphenoxylate or loperamide) may prolong the infection and should not be used. Antibiotics should ...
Antibiotics should not be used, and neither should antidiarrheal agents such as loperamide. Escherichia coli E. coli O104:H4 E ...
At least one mention of the common over-the-counter medication loperamide causing TdP has been made in the literature, although ... Mukarram, O.; Hindi, Y.; Catalasan, G.; Ward, J. (2016). "Loperamide Induced Torsades de Pointes: A Case Report and Review of ...
These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). Mechanisms of peripheral ... a non-sedating antihistamine Loperamide - a μ-opioid receptor agonist used as an antidiarrheal Loratadine - a non-sedating ... including loperamide, domperidone, fexofenadine, bilastine, cetirizine, ivermectin, and dexamethasone, among others. α- ...
Loperamide, an opioid analogue, is commonly used for the symptomatic treatment of diarrhea. Loperamide is not recommended in ...
Baig AM, Rana Z, Mannan M, Tariq S, Ahmad HR (2017). "Antibiotic Effects of Loperamide: Homology of Human Targets of Loperamide ... voltage-gated calcium channels such as TPC-1 and L-type calcium channels and respond to Ca-channel blockers such as loperamide ...
In November 1993 Imodium Lingual (loperamide) from Janssen Pharmaceutica was released in Germany with Zydis technology. In ...
"I Just Wanted to Tell You That Loperamide WILL WORK": A Web-Based Study of Extra-Medical Use of Loperamide". Drug and Alcohol ... At high doses, loperamide has been reported by some drug users to alleviate opioid withdrawal syndrome. The doses reported in ... "Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with "Low Abuse Potential"". The Journal of Emergency Medicine ...
"Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice". Food ... that honey can improve the symptoms of constipation by elevating fecal water content and intestinal transit rate in loperamide‐ ...
For mild disease, supportive care may be sufficient, including loperamide and a low residue or bland diet. For more severe ... and/or loperamide. More severe cases require immune suppression with corticosteroid therapy. If steroids are ineffective, ...
August 2007). "Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's ... Antimotility drugs such as loperamide and diphenoxylate reduce the symptoms of diarrhea by slowing transit time in the gut. ... and can be taken with loperamide to decrease diarrhea. Hospitalization is required in less than 3 percent of cases. Estimates ...
Medications used to slow or stop diarrhea, such as loperamide, may only be used after initiating the treatment. Cholestyramine ...
Antidiarrheal agents, such as loperamide (imodium), should also be avoided as they may prolong the duration of the infection. ...
Loperamide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take loperamide exactly as directed.. If you are giving loperamide to your child, read the package label carefully to make sure ... Before taking loperamide,. *tell your doctor and pharmacist if you are allergic to loperamide, any other medications, or any of ... Loperamide should not be given to a child younger than 2 years of age. Check the package label to find out how much medication ...
... is used to treat diarrhoea. Learn more about its uses, dosage, missed doses, side effects, precautions, ... Loperamide - Handling. How should I handle Loperamide safely?. Loperamide - Storage. How should I store Loperamide ?. ;#Keep ... Loperamide - What is it for. ​Loperamide is used to treat diarrhoea. It works by slowing down the movement of stools in your ... Loperamide - Dosage and How to Use. How should Loperamide be used?. ​You may take this medication with or without food. ...
CDC reports on loperamide abuse leading to cardiac dysrhythmias. ... CDC reports on loperamide abuse leading to cardiac dysrhythmias ... An NPDS loperamide abuse case was defined as any exposure reported to NPDS citing intentional loperamide abuse during January 1 ... "I just wanted to tell you that loperamide WILL WORK": a web-based study of extra-medical use of loperamide. Drug Alcohol Depend ... Opioid withdrawal symptoms after cessation of loperamide were reported by nine patients. Serum loperamide concentrations were ...
Loperamide and Simethicone Warnings/Precautions: Acute ulcerative colitis and antibiotic induced pseudomembranous colitis; ... Loperamide HCl 2mg, simethicone 125mg; chew tabs; caplets; mint flavored; contains calcium. ...
Increased Risk for ESBL-Producing Bacteria from Co-administration of Loperamide and Antimicrobial Drugs for Travelers Diarrhea ... Increased Risk for ESBL-Producing Bacteria from Co-administration of Loperamide and Antimicrobial Drugs for Travelers Diarrhea ...
Instructions for use Loperamide tablets and capsules. Information on dosing for children, contraindications, reviews, analogues ... Loperamide analogs are: Vero-Loperamide, Diara, Imodium, Lopedium, Loperamide-Akrikhin, Loperamide Grindeks, Imodium Plus, ... Video: Loperamide - Instructions, Use For Children, Price, Tablets, Capsules. Video: Imodium (Loperamide Hydrochloride 2mg) ... Loperamide price in pharmacies. The approximate price for Loperamide is 6-15 rubles. (20 tablets in a package), 11-28 rubles. ( ...
... loperamide-simethicone), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... Loperamide is contraindicated in patients aged lonafarnib will increase the level or effect of loperamide by P-glycoprotein ( ... Loperamide is contraindicated in patients aged lonafarnib will increase the level or effect of loperamide by P-glycoprotein ( ... Loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. Discontinue loperamide ...
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Loperamide hydrochloride has a more potent effect than diphenoxylate hydrochloride or codeine. It acts on intestinal muscles to ... The opiate anhydrous morphine, which is contained in paregoric, can decrease motility more than loperamide or the combination ...
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Prolonged use of loperamide can cause a wide range of side effects, but theres another reason you shouldnt take it for longer ... But unless youve read the fine print on the drug label, you may not realize that you should only take loperamide for a very ... They add that you should never take loperamide if you have had an allergic reaction to it in the past, or if you are ... Finally, the FDA warns that you should seek medical care or call 911 and tell them you have taken loperamide if you experience ...
Loperamide (Imodium®) *Kaopectate II caplets *Maalox® anti-diarrheal caplets. *Pepto Diarrhea Control® (follow instructions on ...
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Titrate loperamide to 1-2 bowel movements per day. Table 1: Loperamide Prophylaxis Time on NERLYNX. Loperamide Dose and ... All patients in the prophylaxis cohort received loperamide 4 mg loading dose, followed by 4 mg three times a day from days 1-14 ... You should start taking loperamide with your first dose of NERLYNX.. *After 2 months (56 days) of treatment with NERLYNX, ... Premedication for diarrhea: When not using dose escalation, initiate loperamide with the first dose of NERLYNX and continue ...
loperamide (Diamode or Imodium A-D) for diarrhea. *ibuprofen (Advil or Motrin) for muscle pain ...
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Loperamide. Popular Member of is offering dossier in European CTD format for Loperamide, 2 mg, tablets. Dossier ... Loperamide is classified as an alimentary tract and metabolism medicine, according ATC index. Offer is valid subject to ...
Loperamide poisoning in children. Lancet 1990;335:363. *Motala C, Hill ID, Mann MD, Bowie MD. Effect of loperamide on stool ... One report from Pakistan detailed 18 cases of severe abdominal distention in association with use of loperamide, including at ... loperamide), antisecretory drugs, or toxin binders (e.g., cholestyramine) is a common practice in many developed and developing ... six of 28 patients administered loperamide experienced side effects (i.e., ileus, drowsiness) requiring discontinuation of ...
Q: Is loperamide safe for long-term use?. A: Alternating diarrhea and constipation is always a difficult problem to deal with ... I see no reason why you shouldnt take loperamide with a probiotic should the need arise. Perhaps I should point out that ... Is it alright to take loperamide at the same time as taking a probiotic?. Answer. There is some evidence that taking a ... taking loperamide can sometimes delay recovery. I usually advise patients to take one of the glucose and electrolyte powders ...
  • Loperamide (Imodium) can be bought without a prescription. (
  • Imodium A-D Diarrhea Relief Caplets, Loperamide Hydrochloride, 24 ct. (
  • Imodium A-D Diarrhea Relief Caplets, Loperamide Hydrochloride, 6 ct. (
  • Imodium A-D Anti-Diarrheal Medicine Softgels with Loperamide Hydrochloride, 24 ct. (
  • Imodium A-D Diarrhea Relief Caplets, Loperamide Hydrochloride -Diarrheal Medicine, 48 ct. (
  • Loperamide ( Imodium ®), a commonly used anti-diarrheal, is a mu opioid receptor agonist that, like all opioids , reduces gastrointestinal tract peristalsis . (
  • The anti-diarrheal drug loperamide, often sold as Imodium A-D, is considered safe when used as directed. (
  • IMODIUM® products contain an active ingredient called Loperamide which works to help restore your digestive tract's natural rhythm so you can start to feel like yourself again. (
  • IMODIUM ® A-D Anti-Diarrheal Softgels with Loperamide HCl is an OTC medicine for diarrhea that aims. (
  • Loperamide can be found under the brand name products Imodium A-D and Imodium Multi-Symptom Relief . (
  • Nonprescription (over-the-counter) loperamide is used to control acute diarrhea (loose stools that come on suddenly and usually lasts less than 2 weeks), including travelers' diarrhea. (
  • If you are taking loperamide for acute diarrhea and your symptoms get worse or if your diarrhea lasts longer than 48 hours, stop taking this medication and call your doctor. (
  • Loperamide hydrochloride capsules are indicated for the control and symptomatic relief of acute nonspecific diarrhea in patients 2 years of age and older and of chronic diarrhea in adults associated with inflammatory bowel disease. (
  • patients with diarrhea, an antidiarrheal agent such as loperamide is a drug which slows gut transit. (
  • Loperamide is synthetic opioid that primarily affects opiate receptors in the intestine and is used to treat diarrhea. (
  • According to the instructions, Loperamide is indicated for the symptomatic treatment of chronic and acute diarrhea of various etiologies, including drug, allergic, emotional and radiation, as well as diarrhea caused by changes in the qualitative composition of food and diet, metabolic and absorption disorders. (
  • Loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. (
  • If you are using OTC loperamide and your diarrhea lasts more than two days, stop taking the medicine and contact your health care professional," they write. (
  • In particular, the health authority points out that loperamide should not be used by individuals with dysentery, enterocolitis caused by bacteria, pseudomembranous colitis, stomach pain without diarrhea, and ulcerative colitis. (
  • For adults and children 12 years of age and older who have acute or chronic diarrhea, the recommended dose of loperamide is a starting dose of 4 mg, followed by a 2 mg dose after each loose bowel movement (or bout of diarrhea). (
  • Premedication for diarrhea: When not using dose escalation, initiate loperamide with the first dose of NERLYNX and continue during the first 56 days of treatment. (
  • Diarrhea: Manage diarrhea through either NERLYNX dose escalation or loperamide prophylaxis ( 2.1 , 2.2 ). (
  • What you are looking at is loperamide, a drug used to treat diarrhea. (
  • Perhaps I should point out that diarrhea in gastroenteritis does serve a purpose of clearing out the germs that are causing the problem and, therefore, taking loperamide can sometimes delay recovery . (
  • I usually advise patients to take one of the glucose and electrolyte powders when they get travelers' diarrhea and just use the loperamide for emergencies, traveling, and to get home. (
  • Equate Anti-Diarrheal - Loperamide - 2 mg, 24 Caplets + STS Sticker. (
  • The average loperamide dose was 196.5 mg (range = 2-1,200 mg), and nearly all cases (95%) involved tablets or capsules. (
  • Loperamide tablets are used lingually (by putting on the tongue and waiting for a few seconds for its complete dissolution, then swallowed with saliva without drinking water). (
  • Berkley Jensen Loperamide Hydrochloride Anti-Diarrheal 2 mg Tablets, 24 ct. (
  • Loperamide tablets and capsules are not suitable for children under the age of 6 years old. (
  • Member of is offering dossier in European CTD format for Loperamide, 2 mg, tablets. (
  • In vitro and animal studies show that loperamide hydrochloride capsules act by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. (
  • Plasma concentrations of unchanged drug remain below 2 ng/mL after the intake of a 2 mg capsule of loperamide hydrochloride capsules. (
  • Concomitant use of loperamide hydrochloride capsules with inhibitors of CYP3A4 (e.g., itraconazole) or CYP2C8 (e.g., gemfibrozil) or inhibitors of P-glycoprotein (e.g., quinidine, ritonavir) can increase exposure to loperamide (see PRECAUTIONS: Drug Interactions ). (
  • Loperamide hydrochloride capsules are also indicated for reducing the volume of discharge from ileostomies. (
  • Loperamide binds to the opiate receptor in the gut wall. (
  • Loperamide--an opiate receptor agonist with gastrointestinal motility effects. (
  • recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous system depression, and cardiotoxicity ( 2 - 4 ). (
  • However, reports of individuals misusing loperamide through the use of super- therapeutic doses, alone or in combination with P-glycoprotein and/or CYP450 enzyme inhibitors , is increasing. (
  • We continue to receive reports of serious heart problems and deaths with much higher than the recommended doses of loperamide, primarily among people who are intentionally misusing or abusing the product, despite the addition of a warning to the medicine label and a previous communication," their advisory states. (
  • Abuse of loperamide continues in the United States, and taking higher than recommended doses can cause serious heart problems that can lead to death," said Acting FDA Commissioner Dr. Ned Sharpless in a press release. (
  • Loperamide is safe at approved doses. (
  • This was a result of continued reports of serious heart problems tied to higher-than-recommended doses of loperamide. (
  • Before taking Loperamide , what precautions must I follow? (
  • Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. (
  • Abuse of loperamide for its euphoric effect or for self-treatment of opioid withdrawal is increasing ( 5 ). (
  • Opioid withdrawal symptoms after cessation of loperamide were reported by nine patients. (
  • Education of the public and health care providers regarding the dangers of loperamide abuse is an important component of combating opioid addiction in the United States. (
  • Autoradiographic demonstration of [3H] loperamide binding to opioid receptors in rat and human small intestine. (
  • The action of the drug is due to the binding of loperamide hydrochloride to the opioid receptors of the intestinal wall (stimulation of cholinergic and adrenergic neurons occurs through guanine nucleotides). (
  • An Opioid Hiding in Plain Sight: Loperamide-Induced False-Positive Fentanyl and Buprenorphine Immunoassay Results. (
  • Loperamide hydrochloride is available in 2 mg capsules. (
  • Plasma loperamide concentrations are highest approximately 5 hours after administration of the capsule and 2.5 hours after the liquid. (
  • The peak plasma concentrations of loperamide were similar for both formulations. (
  • Serum loperamide concentrations were obtained from four patients and ranged from 77-210 ng/mL, representing 25-875 times the therapeutic range of 0.24-3.1 ng/mL ( 6 ). (
  • Laboratories using these assays should be aware of the potential for false-positive screening results due to the presence of high concentrations of loperamide and its metabolite dLop. (
  • Loperamide effects on hepatobiliary function, intestinal transit and analgesia in mice. (
  • The opiate anhydrous morphine, which is contained in paregoric, can decrease motility more than loperamide or the combination of diphenoxylate and atropine can. (
  • Discontinue loperamide immediately if constipation occurs. (
  • Discontinue use of loperamide if you notice these side effects. (
  • The drug label warns that you should discontinue use of loperamide if you notice your symptoms worsening, or if you experience abdominal swelling or bulging. (
  • tell your doctor and pharmacist if you are allergic to loperamide, any other medications, or any of the ingredients in loperamide products. (
  • They add that you should never take loperamide if you have had an allergic reaction to it in the past, or if you are experiencing "bloody or black stool. (
  • Loperamide hydrochloride has a more potent effect than diphenoxylate hydrochloride or codeine. (
  • Loperamide is considered to have low abuse potential as it does not produce an analgesic or euphoric effect due to low bioavailability and first-pass metabolism . (
  • Loperamide is classified as an alimentary tract and metabolism medicine, according ATC index. (
  • Loperamide comes as a tablet, capsule, and as a suspension or solution (liquid) to take by mouth. (
  • In vitro loperamide is metabolized mainly by cytochrome P450 (CYP450) isozymes, CYP2C8 and CYP3A4, to form- N-demethyl loperamide. (
  • Excretion of the unchanged loperamide and its metabolites mainly occurs through the feces. (
  • You should not use loperamide to treat these gastrointestinal conditions. (
  • Speak with your doctor if you are unsure of whether your particular gastrointestinal problem can be treated with loperamide. (
  • Loperamide has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. (
  • Loperamide prolongs the transit time of the intestinal contents. (
  • Loperamide is a P-glycoprotein substrate. (
  • These reports were primarily among those who intentionally misused or abused loperamide. (
  • Loperamide is used to treat diarrhoea. (
  • After day 56, use loperamide to maintain 1-2 bowel movements per day. (
  • Each white-to-off-white, round tablet, debossed with 'T' on one side, contains 2 mg of loperamide. (
  • These cases support the reported association between loperamide abuse and cardiac toxicity. (
  • Loperamide is in a class of medications called antidiarrheal agents. (
  • Loperamide belongs to the family of medications called antidiarrheals . (
  • Elimination of loperamide mainly occurs by oxidative N-demethylation. (
  • Cases of loperamide abuse reported to the Upstate New York Poison Center and New York City Poison Control Center were analyzed for demographic, exposure, clinical, and laboratory characteristics. (
  • Cases of intentional loperamide abuse reported to the National Poison Database System (NPDS) also were analyzed for demographic, dose, formulation, and outcome information. (
  • A New York case of loperamide abuse was defined as any call to the Upstate New York Poison Center or New York City Poison Control Center reporting intentional loperamide abuse during January 1, 2008-March 31, 2016. (
  • An NPDS loperamide abuse case was defined as any exposure reported to NPDS citing intentional loperamide abuse during January 1, 2008-March 31, 2016. (
  • Among the 22 New York loperamide abuse cases identified, 18 patients were male. (
  • Health care providers and public health officials should remain vigilant for loperamide abuse and report adverse events to the U.S. Food and Drug Administration's MedWatch reporting system ( external icon ). (
  • Loperamide hydrochloride, 4-(p-chlorophenyl)-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutyramide monohydrochloride, is a synthetic antidiarrheal for oral use. (
  • Loperamide targets the nerve fibers in the large intestine, slowing down the movement of the intestine and thereby the food passing through it. (
  • Loperamide increases the tone of the anal sphincter, thereby reducing incontinence and urgency. (
  • We hypothesized that loperamide could potentially cross-react with laboratory immunoassay drug screens . (
  • Drug -free urine was spiked with loperamide or its principal metabolite, N-desmethyl loperamide (dLop), and assayed on multiple fentanyl and buprenorphine assays. (
  • But unless you've read the fine print on the drug label, you may not realize that you should only take loperamide for a very short period of time before discontinuing use of the product. (
  • dihydroxybergamottin (DHB), and the purported victim drug loperamide. (
  • Prescription loperamide is also used to reduce the amount of fluid in people with ileostomies (surgery to create an opening for waste to leave the body through the abdomen). (
  • Prescription loperamide is sometimes taken on a schedule (one or more times a day). (
  • The maximum loperamide dose per day is 8 mg (OTC) and 16 mg (prescription). (
  • The appointment of loperamide in the II and III trimesters of pregnancy is possible only if the potential threat to the fetus is less than the expected effect of therapy for the mother. (
  • Relative to water, GFJ increased the geometric mean loperamide area under the plasma concentration-time curve (AUC) significantly (1.7-fold). (
  • Fentanyl immunoassay screen-positive results at one institution were examined by high-resolution mass spectrometry (MS) for the presence of loperamide and quantified by liquid chromatography - tandem MS when positive. (