Loperamide

Antidiarrheals

Thiorphan

Senna Extract

Diarrhea

Naloxone

Forensic Pathology

Castor Oil

Piperidines

Loperamide

Pregnancy category

Healthy digestion

Visceral pain

Triplatin tetranitrate

Diphenoxylate

Antipropulsive

Equipment of a combat medic

Nufenoxole

Jean-Charles Schwartz

Tablet (pharmacy)

Janssen Pharmaceuticals

Opioid

Toxic megacolon

Short bowel syndrome

Diarrhea

Gastroenterocolitis

Shigellosis

Escherichia coli O104:H21

Torsades de pointes

Peripherally selective drug

Gastroenteritis

Acanthamoeba

Zydis

Opioid withdrawal

Constipation

Checkpoint inhibitor induced colitis

Travelers' diarrhea

Clostridioides difficile infection

Escherichia coli O157:H7

Imodium10

• Loperamide (Imodium) can be bought without a prescription. (nih.gov)
• Imodium A-D Diarrhea Relief Caplets, Loperamide Hydrochloride, 24 ct. (biggo.sg)
• Imodium A-D Diarrhea Relief Caplets, Loperamide Hydrochloride, 6 ct. (biggo.sg)
• Imodium A-D Anti-Diarrheal Medicine Softgels with Loperamide Hydrochloride, 24 ct. (biggo.sg)
• Imodium A-D Diarrhea Relief Caplets, Loperamide Hydrochloride -Diarrheal Medicine, 48 ct. (biggo.sg)
• Loperamide ( Imodium ®), a commonly used anti-diarrheal, is a mu opioid receptor agonist that, like all opioids , reduces gastrointestinal tract peristalsis . (bvsalud.org)
• The anti-diarrheal drug loperamide, often sold as Imodium A-D, is considered safe when used as directed. (bestlifeonline.com)
• IMODIUM® products contain an active ingredient called Loperamide which works to help restore your digestive tract's natural rhythm so you can start to feel like yourself again. (imodium.com)
• IMODIUM ® A-D Anti-Diarrheal Softgels with Loperamide HCl is an OTC medicine for diarrhea that aims. (imodium.com)
• Loperamide can be found under the brand name products Imodium A-D and Imodium Multi-Symptom Relief . (rxwiki.com)

Diarrhea15

• Nonprescription (over-the-counter) loperamide is used to control acute diarrhea (loose stools that come on suddenly and usually lasts less than 2 weeks), including travelers' diarrhea. (nih.gov)
• If you are taking loperamide for acute diarrhea and your symptoms get worse or if your diarrhea lasts longer than 48 hours, stop taking this medication and call your doctor. (nih.gov)
• Loperamide hydrochloride capsules are indicated for the control and symptomatic relief of acute nonspecific diarrhea in patients 2 years of age and older and of chronic diarrhea in adults associated with inflammatory bowel disease. (nih.gov)
• patients with diarrhea, an antidiarrheal agent such as loperamide is a drug which slows gut transit. (nih.gov)
• Loperamide is synthetic opioid that primarily affects opiate receptors in the intestine and is used to treat diarrhea. (nih.gov)
• According to the instructions, Loperamide is indicated for the symptomatic treatment of chronic and acute diarrhea of various etiologies, including drug, allergic, emotional and radiation, as well as diarrhea caused by changes in the qualitative composition of food and diet, metabolic and absorption disorders. (abchealthonline.com)
• Loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. (medscape.com)
• If you are using OTC loperamide and your diarrhea lasts more than two days, stop taking the medicine and contact your health care professional," they write. (bestlifeonline.com)
• In particular, the health authority points out that loperamide should not be used by individuals with dysentery, enterocolitis caused by bacteria, pseudomembranous colitis, stomach pain without diarrhea, and ulcerative colitis. (bestlifeonline.com)
• For adults and children 12 years of age and older who have acute or chronic diarrhea, the recommended dose of loperamide is a starting dose of 4 mg, followed by a 2 mg dose after each loose bowel movement (or bout of diarrhea). (medbroadcast.com)
• Premedication for diarrhea: When not using dose escalation, initiate loperamide with the first dose of NERLYNX and continue during the first 56 days of treatment. (nih.gov)
• Diarrhea: Manage diarrhea through either NERLYNX dose escalation or loperamide prophylaxis ( 2.1 , 2.2 ). (nih.gov)
• What you are looking at is loperamide, a drug used to treat diarrhea. (smithsonianmag.com)
• Perhaps I should point out that diarrhea in gastroenteritis does serve a purpose of clearing out the germs that are causing the problem and, therefore, taking loperamide can sometimes delay recovery . (iffgd.org)
• I usually advise patients to take one of the glucose and electrolyte powders when they get travelers' diarrhea and just use the loperamide for emergencies, traveling, and to get home. (iffgd.org)

Antidiarrheal agent1

• Loperamide is a symptomatic antidiarrheal agent. (abchealthonline.com)

Caplets1

• Equate Anti-Diarrheal - Loperamide - 2 mg, 24 Caplets + STS Sticker. (biggo.sg)

Tablets5

• The average loperamide dose was 196.5 mg (range = 2-1,200 mg), and nearly all cases (95%) involved tablets or capsules. (cdc.gov)
• Loperamide tablets are used lingually (by putting on the tongue and waiting for a few seconds for its complete dissolution, then swallowed with saliva without drinking water). (abchealthonline.com)
• Berkley Jensen Loperamide Hydrochloride Anti-Diarrheal 2 mg Tablets, 24 ct. (biggo.sg)
• Loperamide tablets and capsules are not suitable for children under the age of 6 years old. (medbroadcast.com)
• Member of Farmavita.net is offering dossier in European CTD format for Loperamide, 2 mg, tablets. (farmavita.net)

Hydrochloride capsules4

• In vitro and animal studies show that loperamide hydrochloride capsules act by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. (nih.gov)
• Plasma concentrations of unchanged drug remain below 2 ng/mL after the intake of a 2 mg capsule of loperamide hydrochloride capsules. (nih.gov)
• Concomitant use of loperamide hydrochloride capsules with inhibitors of CYP3A4 (e.g., itraconazole) or CYP2C8 (e.g., gemfibrozil) or inhibitors of P-glycoprotein (e.g., quinidine, ritonavir) can increase exposure to loperamide (see PRECAUTIONS: Drug Interactions ). (nih.gov)
• Loperamide hydrochloride capsules are also indicated for reducing the volume of discharge from ileostomies. (nih.gov)

Opiate receptor2

• Loperamide binds to the opiate receptor in the gut wall. (nih.gov)
• Loperamide--an opiate receptor agonist with gastrointestinal motility effects. (nih.gov)

Doses6

• recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous system depression, and cardiotoxicity ( 2 - 4 ). (cdc.gov)
• However, reports of individuals misusing loperamide through the use of super- therapeutic doses, alone or in combination with P-glycoprotein and/or CYP450 enzyme inhibitors , is increasing. (bvsalud.org)
• We continue to receive reports of serious heart problems and deaths with much higher than the recommended doses of loperamide, primarily among people who are intentionally misusing or abusing the product, despite the addition of a warning to the medicine label and a previous communication," their advisory states. (bestlifeonline.com)
• Abuse of loperamide continues in the United States, and taking higher than recommended doses can cause serious heart problems that can lead to death," said Acting FDA Commissioner Dr. Ned Sharpless in a press release. (rxwiki.com)
• Loperamide is safe at approved doses. (rxwiki.com)
• This was a result of continued reports of serious heart problems tied to higher-than-recommended doses of loperamide. (rxwiki.com)

Precautions1

• Before taking Loperamide , what precautions must I follow? (nni.com.sg)

Opioid7

• Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. (cdc.gov)
• Abuse of loperamide for its euphoric effect or for self-treatment of opioid withdrawal is increasing ( 5 ). (cdc.gov)
• Opioid withdrawal symptoms after cessation of loperamide were reported by nine patients. (cdc.gov)
• Education of the public and health care providers regarding the dangers of loperamide abuse is an important component of combating opioid addiction in the United States. (cdc.gov)
• Autoradiographic demonstration of [3H] loperamide binding to opioid receptors in rat and human small intestine. (nih.gov)
• The action of the drug is due to the binding of loperamide hydrochloride to the opioid receptors of the intestinal wall (stimulation of cholinergic and adrenergic neurons occurs through guanine nucleotides). (abchealthonline.com)
• An Opioid Hiding in Plain Sight: Loperamide-Induced False-Positive Fentanyl and Buprenorphine Immunoassay Results. (bvsalud.org)

Capsules1

• Loperamide hydrochloride is available in 2 mg capsules. (nih.gov)

Concentrations4

• Plasma loperamide concentrations are highest approximately 5 hours after administration of the capsule and 2.5 hours after the liquid. (nih.gov)
• The peak plasma concentrations of loperamide were similar for both formulations. (nih.gov)
• Serum loperamide concentrations were obtained from four patients and ranged from 77-210 ng/mL, representing 25-875 times the therapeutic range of 0.24-3.1 ng/mL ( 6 ). (cdc.gov)
• Laboratories using these assays should be aware of the potential for false-positive screening results due to the presence of high concentrations of loperamide and its metabolite dLop. (bvsalud.org)

Intestinal transit1

• Loperamide effects on hepatobiliary function, intestinal transit and analgesia in mice. (nih.gov)

Motility1

• The opiate anhydrous morphine, which is contained in paregoric, can decrease motility more than loperamide or the combination of diphenoxylate and atropine can. (medscape.com)

Discontinue3

• Discontinue loperamide immediately if constipation occurs. (medscape.com)
• Discontinue use of loperamide if you notice these side effects. (bestlifeonline.com)
• The drug label warns that you should discontinue use of loperamide if you notice your symptoms worsening, or if you experience abdominal swelling or bulging. (bestlifeonline.com)

Allergic2

• tell your doctor and pharmacist if you are allergic to loperamide, any other medications, or any of the ingredients in loperamide products. (nih.gov)
• They add that you should never take loperamide if you have had an allergic reaction to it in the past, or if you are experiencing "bloody or black stool. (bestlifeonline.com)

Diphenoxylate1

• Loperamide hydrochloride has a more potent effect than diphenoxylate hydrochloride or codeine. (medscape.com)

Metabolism2

• Loperamide is considered to have low abuse potential as it does not produce an analgesic or euphoric effect due to low bioavailability and first-pass metabolism . (bvsalud.org)
• Loperamide is classified as an alimentary tract and metabolism medicine, according ATC index. (farmavita.net)

Capsule1

• Loperamide comes as a tablet, capsule, and as a suspension or solution (liquid) to take by mouth. (nih.gov)

CYP3A41

• In vitro loperamide is metabolized mainly by cytochrome P450 (CYP450) isozymes, CYP2C8 and CYP3A4, to form- N-demethyl loperamide. (nih.gov)

Metabolites1

• Excretion of the unchanged loperamide and its metabolites mainly occurs through the feces. (nih.gov)

Gastrointestinal2

• You should not use loperamide to treat these gastrointestinal conditions. (bestlifeonline.com)
• Speak with your doctor if you are unsure of whether your particular gastrointestinal problem can be treated with loperamide. (bestlifeonline.com)

Serum1

• Loperamide has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. (nih.gov)

Transit1

• Loperamide prolongs the transit time of the intestinal contents. (nih.gov)

Substrate1

• Loperamide is a P-glycoprotein substrate. (nih.gov)

Primarily among1

• These reports were primarily among those who intentionally misused or abused loperamide. (rxwiki.com)

Diarrhoea1

• Loperamide is used to treat diarrhoea. (nni.com.sg)

Bowel movements1

• After day 56, use loperamide to maintain 1-2 bowel movements per day. (nih.gov)

Tablet1

• Each white-to-off-white, round tablet, debossed with 'T' on one side, contains 2 mg of loperamide. (medbroadcast.com)

Cardiac1

• These cases support the reported association between loperamide abuse and cardiac toxicity. (cdc.gov)

Medications called2

• Loperamide is in a class of medications called antidiarrheal agents. (nih.gov)
• Loperamide belongs to the family of medications called antidiarrheals . (medbroadcast.com)

Occurs1

• Elimination of loperamide mainly occurs by oxidative N-demethylation. (nih.gov)

Abuse6

• Cases of loperamide abuse reported to the Upstate New York Poison Center and New York City Poison Control Center were analyzed for demographic, exposure, clinical, and laboratory characteristics. (cdc.gov)
• Cases of intentional loperamide abuse reported to the National Poison Database System (NPDS) also were analyzed for demographic, dose, formulation, and outcome information. (cdc.gov)
• A New York case of loperamide abuse was defined as any call to the Upstate New York Poison Center or New York City Poison Control Center reporting intentional loperamide abuse during January 1, 2008-March 31, 2016. (cdc.gov)
• An NPDS loperamide abuse case was defined as any exposure reported to NPDS citing intentional loperamide abuse during January 1, 2008-March 31, 2016. (cdc.gov)
• Among the 22 New York loperamide abuse cases identified, 18 patients were male. (cdc.gov)
• Health care providers and public health officials should remain vigilant for loperamide abuse and report adverse events to the U.S. Food and Drug Administration's MedWatch reporting system ( http://www.fda.gov/Safety/MedWatch external icon ). (cdc.gov)

Synthetic1

• Loperamide hydrochloride, 4-(p-chlorophenyl)-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutyramide monohydrochloride, is a synthetic antidiarrheal for oral use. (nih.gov)

Intestine1

• Loperamide targets the nerve fibers in the large intestine, slowing down the movement of the intestine and thereby the food passing through it. (smithsonianmag.com)

Increases1

• Loperamide increases the tone of the anal sphincter, thereby reducing incontinence and urgency. (nih.gov)

Drug4

• We hypothesized that loperamide could potentially cross-react with laboratory immunoassay drug screens . (bvsalud.org)
• Drug -free urine was spiked with loperamide or its principal metabolite, N-desmethyl loperamide (dLop), and assayed on multiple fentanyl and buprenorphine assays. (bvsalud.org)
• But unless you've read the fine print on the drug label, you may not realize that you should only take loperamide for a very short period of time before discontinuing use of the product. (bestlifeonline.com)
• dihydroxybergamottin (DHB), and the purported victim drug loperamide. (nih.gov)

Prescription3

• Prescription loperamide is also used to reduce the amount of fluid in people with ileostomies (surgery to create an opening for waste to leave the body through the abdomen). (nih.gov)
• Prescription loperamide is sometimes taken on a schedule (one or more times a day). (nih.gov)
• The maximum loperamide dose per day is 8 mg (OTC) and 16 mg (prescription). (rxwiki.com)

Pregnancy1

• The appointment of loperamide in the II and III trimesters of pregnancy is possible only if the potential threat to the fetus is less than the expected effect of therapy for the mother. (abchealthonline.com)

Concentration1

• Relative to water, GFJ increased the geometric mean loperamide area under the plasma concentration-time curve (AUC) significantly (1.7-fold). (nih.gov)

Results1

• Fentanyl immunoassay screen-positive results at one institution were examined by high-resolution mass spectrometry (MS) for the presence of loperamide and quantified by liquid chromatography - tandem MS when positive. (bvsalud.org)