Drugs used to cause constriction of the blood vessels.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The nonstriated involuntary muscle tissue of blood vessels.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
The flow of BLOOD through or around an organ or region of the body.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Drugs used to cause dilation of the blood vessels.
Part of the arm in humans and primates extending from the ELBOW to the WRIST.
An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.
The circulation of the BLOOD through the vessels of the KIDNEY.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
The vessels carrying blood away from the heart.
An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
A subtype of endothelin receptor found predominantly in the KIDNEY. It may play a role in reducing systemic ENDOTHELIN levels.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
Teleost hormones. A family of small peptides isolated from urophyses of bony fishes. They have many different physiological effects, including long-lasting hypotensive activity and have been proposed as antihypertensives. There are at least four different compounds: urotensin I, urotensin II, urotensin III, and urotensin IV.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Treatment process involving the injection of fluid into an organ or tissue.
Drugs that selectively bind to and activate alpha adrenergic receptors.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Cell surface proteins that bind THROMBOXANES with high affinity and trigger intracellular changes influencing the behavior of cells. Some thromboxane receptors act via the inositol phosphate and diacylglycerol second messenger systems.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)
A norepinephrine derivative used as a vasoconstrictor agent.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
The circulation of the BLOOD through the LUNGS.
The TEMPERATURE at the outer surface of the body.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Nerve fibers liberating catecholamines at a synapse after an impulse.
A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions.
An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)
Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters.
A competitive inhibitor of nitric oxide synthetase.
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Yagiela JA (1995). "Vasoconstrictor agents for local anesthesia". Anesth Prog. 42 (3-4): 116-20. PMC 2148913. PMID 8934977. ... Vasoconstrictors mixed with local anesthetics are used to increase the duration of local anesthesia by constricting the blood ... Moodley, DS (2017). "Local anaesthetics in dentistry-Part 3: Vasoconstrictors in local anaesthetics" (PDF). South African ... Vasoconstrictors are also used clinically to increase blood pressure or to reduce local blood flow. ...
"Vasoconstrictor agents for local anesthesia". Anesth Prog. 42 (3-4): 116-20. PMC 2148913. PMID 8934977.. ... Vasoconstrictors are also used clinically to increase blood pressure or to reduce local blood flow. Vasoconstrictors mixed with ... Vasoconstrictor[4]. Receptor (↑ = opens. ↓ = closes)[4] On vascular smooth muscle cells if not otherwise specified Transduction ... Many vasoconstrictors also cause pupil dilation. Medications that cause vasoconstriction include: antihistamines, decongestants ...
ISBN 978-0-07-136704-2. Yagiela JA (1995). "Vasoconstrictor agents for local anesthesia". Anesthesia Progress. 42 (3-4): 116-20 ... Local anesthetic solutions for injection typically consist of: The local anesthetic agent itself A vehicle, which is usually ... the half-life of amide local anaesthetic agents may be drastically increased thus increasing the risk of overdose. Local ... Because the vasoconstrictor temporarily reduces the rate at which the systemic circulation removes the local anesthetic from ...
There are no restrictions regarding the type of local anaesthetic agent used although those with vasoconstrictors may provide ... and local measures, such as the use of oxidized cellulose, for example, Surgicel or fibrin glue in conjunction with post- ... operatively administered antifibrinolytic agents where appropriate. The use of any non-steroidal anti-inflammatory drug (NSAID ... The protocols suggest the use of factor concentrate along with the use of local hemostatic techniques, such as suturing, ...
Ferric sulphate, sodium hypochlorite or a local anaesthetic solution containing a vasoconstrictor agent can be used to arrest ... It is also recommended to be the preferred pulpotomy agent in the future. After the coronal pulp chamber is filled, the tooth ... Fei, A. L.; Udin, R. D.; Johnson, R. (November 1991). "A clinical study of ferric sulfate as a pulpotomy agent in primary teeth ... Calcium hydroxide Ca(OH)2 is conventionally used as a pulpotomy agent of the permanent teeth but with less long term success. ...
Some agents come in two forms: with and without epinephrine (adrenaline) or other vasoconstrictor that allow the agent to last ... There are mainly 2 classes of local anaesthetic agents: Amide or Ester linkages, based on their chemical structure. E.g. of ... In root canal treatment, for example, more Lidocaine is required than for a simple filling Other local anesthetic agents in ... doi:10.1034/j.1601-1546.2002.10103.x. Henderson S (2011). "Allergy to local anaesthetic agents used in dentistry--what are the ...
... as a vasoconstrictor to slow the absorption and, therefore, prolong the action of the anesthetic agent. Due to epinephrine's ... Local anesthetics[edit]. Adrenaline is added to injectable forms of a number of local anesthetics, such as bupivacaine and ... Rahn R, Ball B (2001). Local Anesthesia in Dentistry: Articaine and Epinephrine for Dental Anesthesia (1 st ed.). Seefeld, ... Some of the adverse effects of local anesthetic use, such as apprehension, tachycardia, and tremor, may be caused by adrenaline ...
"Vasoconstrictor agents for local anesthesia". Anesth Prog. 42 (3-4): 116-20. PMC 2148913. PMID 8934977.. ... Vasoconstrictors are also used clinically to increase blood pressure or to reduce local blood flow. Vasoconstrictors mixed with ... Vasoconstrictor[4]. Receptor (↑ = opens. ↓ = closes)[4] On vascular smooth muscle cells if not otherwise specified Transduction ... Redirected from Vasoconstrictors). Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the ...
... it is a phentolamine mesylate injection designed to reverse the local vasoconstrictor properties used in many local anesthetics ... Phentolamine is marketed in the dental field as a local anesthetic reversal agent. Branded as OraVerse, ... It is important to note that phentolamine is not a first-line agent for this indication. Phentolamine should only be given to ... Malamed S (January 2009). "What's new in local anaesthesia?". SAAD Digest. 25: 4-14. PMID 19267135. US 2503059, Miescher K, ...
It is very important to limit the use of vasoconstrictor in local anesthesia, with no more than two carpules. The treatment ... In patients who has been administered with digitalis agents (digoxin, methyl-digoxin), the vasoconstrictor dose should be ...
Brain tissue has ACE enzyme, which takes part in local RAS and converts Aβ42 (which aggregates into plaques) to Aβ40 (which is ... Therefore, ACE can be inhibited by metal-chelating agents. The E384 residue was found to have a dual function. First it acts as ... Thus, the same enzyme (ACE) that generates a vasoconstrictor (ANG II) also disposes of vasodilators (bradykinin). ACE is a zinc ... Angiotensin II is a potent vasoconstrictor in a substrate concentration-dependent manner. Angiotensin II binds to the type 1 ...
In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... The main classes of painkillers are NSAIDs, opioids and local anesthetics. For consciousness (anesthetic drugs) Some ... vasoconstrictors, vasodilators. Affecting blood pressure/(antihypertensive drugs): ACE inhibitors, angiotensin receptor ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
... with the vasoactive pharmacological agents (vasoconstrictors or vasodilators and/or ACE Inhibitors and/or ARBs)(ACE = ... WR Milnor: Hemodynamics, Williams & Wilkins, 1982 "Local Biomed Device Aiding NASA". Van De Water, Joseph M.; Miller, Timothy W ... cardioactive or vasoactive agents. The measurement of CI and its derivatives allow clinicians to make timely patient assessment ... Pharmacological modulation of contractility is performed with cardioactive inotropic agents (positive or negative inotropes) ...
Dibucaine number Epidural Intravenous regional anesthesia Local anesthesia Local anesthetic with vasoconstrictor Local ... This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are ... 4-Aminobenzoic acid Amino amide Amino esters Anesthesia Anesthetic Brachial plexus block Cocaine analogues: local anesthetics ...
... usually in a pre-mixed solution with local anesthetics, such as mepivacaine). Corbadrine is also a metabolite of the ... is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States ... Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 164-. ISBN 978-0- ...
Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Local inflammatory response.. As per bufexamac. Feprazone. Comes in free acid and piperazine salt forms. Phenylbutazone.. As ... They can also be found in combination with vasoconstrictor drugs such as pseudoephedrine for sinus-related preparations, or ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ...
... eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to ... Short acting vasoconstrictors - TXA2-are released quickly after the injury. The site may momentarily turn pale. Then TXA2 ... Many of the prostanoids are known to mediate local symptoms of inflammation: vasoconstriction or vasodilation, coagulation, ... Heat-PGE2 is also a potent pyretic agent. Aspirin and NSAIDS-drugs that block the COX pathways and stop prostanoid synthesis- ...
locally acting hemostatic agents work by causing vasoconstriction or promoting platelet aggregation. Hemostatic agents are used ... Anhydrous aluminium sulfate is the main ingredient and acts as a vasoconstrictor in order to disable blood flow. The stick is ... The high ionic strength promotes flocculation of the blood, and the astringent chemical causes local vasoconstriction. Before ... agent. Antihemorrhagic agents used in medicine have various mechanisms of action: Systemic drugs work by inhibiting ...
Topical cocaine can be used as a local numbing agent to help with painful procedures in the mouth or nose. Cocaine is now ... If vasoconstriction is desired for a procedure (as it reduces bleeding), the anesthetic is combined with a vasoconstrictor such ... Because of its use as a local anesthetic, a suffix "-caine" was later extracted and used to form names of synthetic local ... Cocaine was introduced into clinical use as a local anesthetic in Germany in 1884, about the same time as Sigmund Freud ...
Compression of a trigger point may elicit local tenderness, referred pain, or local twitch response. The local twitch response ... or articaine without vasoconstrictors like epinephrine, steroids, and botulinum toxin provide more immediate relief and can be ... Despite the concerns about long acting agents, a mixture of lidocaine and marcaine is often used. A mixture of 1 part 2% ... These sustained contractions of muscle sarcomeres compresses local blood supply restricting the energy needs of the local ...
Serotonin was found to be among the candidate agents to be included. In the same period, serotonin was isolated (1948) and, ... In 1974 Saxena showed that methysergide had a selective vasoconstrictor effect in the carotid bed and in 1984 he found an ... Less known is his search for a perivascular factor that would damage local tissues and increase pain sensitivity during ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... Antibiotics, sympathomimetics, antihistamines, anticholinergics, NSAIDs, corticosteroids, antiseptics, local anesthetics, ... vasoconstrictors, vasodilators. ... The main classes of painkillers are NSAIDs, opioids and Local ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ...
... local MeSH D27.505.954.122.237 - anti-infective agents, urinary MeSH D27.505.954.122.250 - antiparasitic agents MeSH D27.505. ... vasoconstrictor agents MeSH D27.505.954.411.793.205 - calcium channel agonists MeSH D27.505.954.411.793.610 - nasal ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ...
Local numbing agentEdit. The efficacy profile of lidocaine as a local anaesthetic is characterized by a rapid onset of action ... Nielsen LJ, Lumholt P, Hölmich LR (October 2014). "[Local anaesthesia with vasoconstrictor is safe to use in areas with end- ... As a local numbing agent, it is used for the treatment of premature ejaculation.[15] ... "Local anaesthetic drugs".. *^ Cepeda MS, Tzortzopoulou A, Thackrey M, Hudcova J, Arora Gandhi P, Schumann R (December 2010). ...
As a local numbing agent, it is used for the treatment of premature ejaculation. An adhesive transdermal patch containing a 5% ... ISBN 978-0-9757919-2-9.[page needed] Nielsen LJ, Lumholt P, Hölmich LR (October 2014). "[Local anaesthesia with vasoconstrictor ... When used for local anaesthesia or in nerve blocks, lidocaine typically begins working within several minutes and lasts for ... "Local anaesthetic drugs". Cepeda MS, Tzortzopoulou A, Thackrey M, Hudcova J, Arora Gandhi P, Schumann R (December 2010). ...
Angiotensin II is a vasoconstrictor which will increase blood flow to the heart and subsequently the preload, ultimately ... a finding consistent with reduced local cerebral blood flow[49] and a heightened risk of cerebrovascular disease.[50] Within ... also contributes to changing the caliber of small blood vessels and influencing resistance and reactivity to vasoactive agents. ... Substances called vasoconstrictors reduce the caliber of blood vessels, thereby increasing blood pressure. Vasodilators (such ...
"The Use Of Local Agents: Bone Wax, Gelatin, Collagen, Oxidized Cellulose." European Spine Journal 2004; 13.: S89-S96. ... Adenosine diphosphate (ADP) attracts more platelets to the affected area, serotonin is a vasoconstrictor and thromboxane A2 ... Hemostasis can be achieved by chemical agent as well as mechanical or physical agents. Which hemostasis type used is determined ... Physical agents (gelatin sponge)- Gelatin sponges have been indicated as great hemostatic devices. Once applied to a bleeding ...
During this time, he began his life in research as a volunteer in the local hospital hematology lab. In 1936 Crosby entered the ... Vasoconstrictor action of cocaine. Journal of Pharmacology and Experimental Therapeutics. 1939 65:150-155. Crosby's Syndrome, ... 1964 May 22;144:1015-6 Effect of agents simulating the abnormalities of the glucose-6-phosphate dehydrogenase-deficient red ...
Most bark is collected illegally by local people who are paid 150 CFA francs per kilo (about US$0.10 per pound) for delivery of ... norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under ... The bark is traded in local markets and, because it is scarce, it is often adulterated with that of other species which contain ... Norepinephrine releasing agents. *Stimulants. *Sympathomimetics. *Vasoconstrictors. *Vasodilators. Hidden categories: *CS1 ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... Antibiotics, sympathomimetics, antihistamines, anticholinergics, NSAIDs, corticosteroids, antiseptics, local anesthetics, ... vasoconstrictors, vasodilators. ... The main classes of painkillers are NSAIDs, opioids and Local ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ...
Abrupt increase in systemic vascular resistance, likely related to humoral vasoconstrictors. *Endothelial injury and ... Several classes of antihypertensive agents are recommended, with the choice depending on the cause of the hypertensive crisis, ... leading to loss of cerebral and local autoregulation, organ system ischemia and dysfunction, and myocardial infarction.[10] ... Other intravenous agents like nitroglycerine, nicardipine, labetalol, fenoldopam or phentolamine can also be used, but all have ...
न्यालक्सेन, although chemically similar to some analgesics, is not a painkiller र reverses the effects of morphine-like agents. ... Anesthetic/anesthetic - Lidocaine/prilocaine Anesthetic/vasoconstrictor - Iontocaine. #WHO-EM. ‡Withdrawn from market. Clinical ... Anesthetics: Local anesthetics - primarily sodium channel blockers (N01B). Esters. Esters of aminobenzoic acid ...
Local inflammatory response.. As per bufexamac. Feprazone. Comes in free acid and piperazine salt forms. Phenylbutazone.. As ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ... They can also be found in combination with vasoconstrictor drugs such as pseudoephedrine for sinus-related preparations, or ... Local inflammation and pain.. As per diclofenac. Magnesium salicylate. Comes in free form; soluble in water and ethanol; ...
Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187-93. ... sclerosing agents for local injection. *Monoethanolamine oleate. *Polidocanol. *Inverted sugar syrup. *Sodium tetradecyl ... Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular ... Prior to the discovery of amylocaine and procaine, cocaine was a commonly used local anesthetic.[5] Einhorn wished his new ...
Systemic administration of local anesthetic agents to relieve neuropathic pain PMID 16235318 https://doi.org/10.1002/14651858. ... Topical anaesthetic or vasoconstrictor preparations for flexible fibre-optic nasal pharyngoscopy and laryngoscopy PMID 21412890 ... Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection in adults ... Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in ...
As a pharmaceutical, m-synephrine is still used as a sympathomimetic (i.e. for its hypertensive and vasoconstrictor properties ... McCulloch J, Deshmukh VD, Harper AM (1978). Indirect sympathomimetic agents and cerebral blood flow and metabolism. Eur J ... solutions of the drug to the nasal mucosa of patients with sinusitis did produce a beneficial constriction without local ... In experiments with isolated sheep carotid artery, d-, l- and d,l-synephrine all showed some vasoconstrictor activity: l- ...
Note that during fatty synthesis the reducing agent is NADPH, whereas NAD is the oxidizing agent in beta-oxidation (the ... They also act as local hormones. Prostaglandins were originally believed to leave the cells via passive diffusion because of ... Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet aggregation. Their name ... and local hormones in the immediate vicinity of the cell. The prostaglandins made from arachidonic acid stored in the cell ...
Amide-linked local anesthetic agents, such as lidocaine and bupivacaine, can become "trapped" in their ionized forms on the ... An ester-linked local anesthetic agent, such as 2-chloroprocaine, is rapidly metabolized, and placental transfer is limited. ... chloroprocaine is an ester-type local anaesthetic with the shortest duration of action of all the established local ... is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine vasodilates; this is ...
Local anesthetics: lidocaine. *Class I antiarrhythmic agents. *Various anticonvulsants: phenytoin, oxcarbazepine (derivative of ... Of the sodium channel blocking antiarrhythmic agents (the class I antiarrhythmic agents), the class Ic agents have the most ... Class I antiarrhythmic agents interfere with the (Na+) channel. Class I agents are grouped by their effect on the Na+ channel, ... Agents in this class also cause decreased conductivity and increased refractoriness. Indications for Class Ia agents are ...
sclerosing agents for local injection. *Monoethanolamine oleate. *Polidocanol. *Inverted sugar syrup. *Sodium tetradecyl ... Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting ... local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under ...
"Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression". Nature Neuroscience ... Ergotamine (vasoconstrictor in migraine). *Oxymetazoline. *Sumatriptan (vasoconstrictor in migraine). *Zolmitriptan. *5- ...
A nasogastric tube is used for feeding and administering drugs and other oral agents such as activated charcoal. For drugs and ... The end of a plastic tube is lubricated (local anesthetic, such as 2% xylocaine gel, may be used; in addition, nasal ... vasoconstrictor and/or anesthetic spray may be applied before the insertion) and inserted into one of the patient's anterior ...
This form is eaten in the lower regions of Bhutan and in North Bengal, where the nut is cut into half and put into a local paan ... The betel leaf chewed along with the nut contains eugenol, another vasoconstrictor. Tobacco leaf is often added to the mixture ... ISBN 978-92-832-1285-0. See table for Group 1 carcinogen agents in Beatrice Secretan; et al. (2009). "A review of human ... In October 2009, 30 scientists from 10 countries met at IARC to reassess the carcinogenicity of various agents including areca ...
... after 12 months of follow-up was better in the aluminum chloride group than in the anesthetic solution with vasoconstrictor ... Influence of hemostatic agents upon the outcome of periapical surgery: dressings with anesthetic and vasoconstrictor or ... We included patients with a minimum follow-up of 12 months, divided into two groups according to the hemostatic agent used: A) ... There were 50 patients in the aluminum chloride group and 46 patients in the anesthetic solution with vasoconstrictor group. No ...
Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of ... For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities. ...
Antibiotic ointments help prevent local infection and provide local moisturization.. Mupirocin ointment 2% (Bactroban nasal). * ... Topical vasoconstrictors. Class Summary. Topical vasoconstrictors act on alpha-adrenergic receptors in the nasal mucosa, ... Cauterizing agents. Class Summary. Cauterizing agents coagulate cellular proteins, which can in turn reduce bleeding. ... When anesthetics are used concomitantly with vasoconstrictors, their anesthetic effect is prolonged and the pain threshold ...
"Vasoconstrictor agents for local anesthesia". Anesthesia Progress. 42 (3-4): 116-20. PMC 2148913. PMID 8934977.. ... List of local anesthetics. References[edit]. *^ Ryan, T (2019). "Tramadol as an adjunct to intra‐articular local anaesthetic ... Vasoconstrictor possibly (see below). *Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is ... Local anaesthetics and vasoconstrictors may be administered to pregnant patients however it is very important to be extra ...
"Vasoconstrictor agents for local anesthesia". Anesth Prog. 42 (3-4): 116-20. PMC 2148913. PMID 8934977.. ... Vasoconstrictors are also used clinically to increase blood pressure or to reduce local blood flow. Vasoconstrictors mixed with ... "Local anaesthetics in dentistry-Part 3: Vasoconstrictors in local anaesthetics" (PDF). South African Dental Journal. 72: 176- ... Vasoconstrictor[5] Receptor (↑ = opens. ↓ = closes)[5] On vascular smooth muscle cells if not otherwise specified Transduction ...
Peripheral Nervous System Agents. Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Vasoconstrictor Agents. ...
Peripheral Nervous System Agents. Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Vasoconstrictor Agents. ... Dopamine Agents. Neurotransmitter Agents. Antiparkinson Agents. Anti-Dyskinesia Agents. Aromatic Amino Acid Decarboxylase ...
w with local anaesthetic agents, as a vasoconstrictor. - a2-receptors: yohimbine. w in anaphylactic reaction, cardiac arrest, ... the nerve). 5-10 ml local anaesthetic agent is injected 2 cm See also, Pelvic trauma below the mastoid process into the ... ARDS), regardless of the level of PEEP.l Possible mechanisms: The definitions of ALI and ARDS are increasingly being w local ... 2. 2 ABO blood groups men, the urethral meatus) for bruises, lacerations, entry Abuse of anaesthetic agents. May occur because ...
0 (Anesthetics, Local); 0 (Neurotransmitter Agents); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 33507-63-0 (Substance ... Effect of local anesthetics with and without vasoconstrictor agent in patients with ventricular arrhythmias.. ... 0 (Anesthetics, Local); 0 (Drug Combinations); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 56-59-7 (Felypressin). ... 0 (Anesthetics, Local); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 56-59-7 (Felypressin); 98PI200987 (Lidocaine). ...
Intranasal cocaine is used frequently as a local anesthetic during many rhinolaryngologic procedures. Although its ... Vasoconstrictor Agents* / administration & dosage Substances * Adrenergic alpha-Antagonists * Anesthetics, Local * ... Subsequently, the administration of the alpha-adrenergic blocking agent phentolamine caused all these values to return to base- ... Intranasal cocaine is used frequently as a local anesthetic during many rhinolaryngologic procedures. Although its " ...
"Vasoconstrictor agents for local anesthesia". Anesth Prog. 42 (3-4): 116-20. PMC 2148913. PMID 8934977.. ... Vasoconstrictors are also used clinically to increase blood pressure or to reduce local blood flow. Vasoconstrictors mixed with ... Vasoconstrictor[4]. Receptor (↑ = opens. ↓ = closes)[4] On vascular smooth muscle cells if not otherwise specified Transduction ... Redirected from Vasoconstrictors). Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the ...
"Vasoconstrictor agents for local anesthesia". Anesth Prog. 42 (3-4): 116-20. PMC 2148913. PMID 8934977.. ... Vasoconstrictors are also used clinically to increase blood pressure or to reduce local blood flow. Vasoconstrictors mixed with ... Vasoconstrictor[4]. Receptor (↑ = opens. ↓ = closes)[4] On vascular smooth muscle cells if not otherwise specified Transduction ... Many vasoconstrictors also cause pupil dilation. Medications that cause vasoconstriction include: antihistamines, decongestants ...
Overview of Local Anesthetic Agents & Vasoconstrictors [More Info]. Speaker: Chadleo Webb. Thursday 06/21/2018. 1:00 pm - 2:00 ...
p>Written by a dental hygienist for dental hygienists, Local Anesthesia for the Dental Hygienist helps you ... learn the safe and effective administration of local anesthesia. Coverage is tailored to fit the role and needs of the dental ... and promotes patient-centered care by integrating discussions of the Human Needs Paradigm with complete instructions for local ... Appendix 8-1: Summary of Local Anesthetic Agents and Vasoconstrictors. Section IV: Local Anesthetic Techniques for the Dental ...
Determine the pharmacology of anesthetic agents and vasoconstrictors. *Recognize medical history status and administration of ... Local Anesthesia for Dental Hygienists. Thursday, Oct. 26 through Saturday, Oct. 28, 2017, from 8 a.m. until 5 p.m. at the ... In 2006, she became certified in the administration of Local Anesthesia (CT). She is an associateprofessor and director of the ... Through a combination of lecture and hands-on lab work, participants will gain skills in the implementation of local anesthesia ...
They may also inject a vasoconstrictor agent (a medicine used to narrow blood vessels). If this approach doesnt work, you may ... For immediate relief and to restore normal blood flow to prevent permanent damage, the doctor may use a needle under local ... These measures would be in addition to draining the extra blood trapped in the penis and injecting a vasoconstrictor agent. ...
... an antioxidizing agent included in local anesthetics to minimize oxidation of the vasoconstrictor, may exacerbate asthma; and ...
Studies were conducted on 3-day-old (range 2-4 days) and 35-day-old (range 32-40 days) swine obtained from a local breeding ... Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine. Philip T. Nowicki ... Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine ... Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine ...
Sympathomimetic (adrenergic) agents*Topical sympathomimetic agents*Vasoconstrictors. Indications and usages, anatomical ... Pharmaceutical companies: manufacturers, researchers, developers, local distributors and suppliers:. *ERFA. Where to buy ...
Sympathomimetic (adrenergic) agents*Topical sympathomimetic agents*Vasoconstrictors. Indications and usages, anatomical ... Pharmaceutical companies: manufacturers, researchers, developers, local distributors and suppliers:. *Stallergenes. Find online ...
Sympathomimetic (adrenergic) agents*Topical sympathomimetic agents*Vasoconstrictors. Indications and usages, anatomical ... Pharmaceutical companies: manufacturers, researchers, developers, local distributors and suppliers:. *Teva. Find online ...
"Vasoconstrictor agents should be used in local anesthesia solutions during dental practice only when it is clear that the ... Local anesthetic solutions containing a vasoconstrictor should be used with caution in areas of the body supplied by end ... These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the ... DENTAL PRACTITIONERS WHO EMPLOY LOCAL ANESTHETIC AGENTS SHOULD BE WELL VERSED IN DIAGNOSIS AND MANAGEMENT OF EMERGENCIES WHICH ...
"Vasoconstrictor agents should be used in local anesthesia solutions during dental practice only when it is clear that the ... is a sterile isotonic solution containing a local anesthetic agent, Lidocaine Hydrochloride, and a vasoconstrictor, Epinephrine ... Local anesthetic solutions containing a vasoconstrictor should be used with caution in areas of the body supplied by end ... These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the ...
"Vasoconstrictor agents should be used in local anesthesia solutions during dental practice only when it is clear that the ... USP is a sterile isotonic solution containing a local anesthetic agent, Lidocaine Hydrochloride, and a vasoconstrictor, ... Local anesthetic solutions containing a vasoconstrictor should be used with caution in areas of the body supplied by end ... These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the ...
Vasoconstrictor Agents. Serotonin 5-HT1 Receptor Agonists. Serotonin Receptor Agonists. Serotonin Agents. Neurotransmitter ... Dermatologic Agents. Histamine H1 Antagonists. Histamine Antagonists. Histamine Agents. Anti-Allergic Agents. Sleep Aids, ... Agents. Molecular Mechanisms of Pharmacological Action. Physiological Effects of Drugs. Antipruritics. ...
Methods comprise adding a skin concentration enhancing amount of a vasoconstrictor to an active agent and delivering by ... for iontophoretic delivery which comprise a skin concentration enhancing amount of a vasoconstrictor and active agent. ... The invention discloses methods and compositions for enhanced skin concentration of iontophoretic delivered active agents. The ... Preferably the active agent is a local anesthetic.. Primary requirements of an active agent are that it be charged or capable ...
  • PURPOSE: Epinephrine is considered the gold standard vasoconstrictor for hypertensive patients, but few studies report felypressin's effects. (bireme.br)
  • LIGNOSPAN FORTE and LIGNOSPAN STANDARD are sterile isotonic solution containing a local anesthetic agent, Lidocaine Hydrochloride, and a vasoconstrictor, Epinephrine (as bitartrate) and are administered parenterally by injection. (drugs.com)
  • These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system and/or the beta-adrenergic receptor stimulating action of epinephrine when present. (drugs.com)
  • Epinephrine bitartrate, (-)-1-(3,4-Dihydroxyphenyl)-2-methylamino-ethanol (+) tartrate (1:1) salt, is a vasoconstrictor that is added to articaine HCl in a concentration of 1:200,000 or 1:100,000 (expressed as free base). (rxlist.com)
  • Septocaine® (articane hcl and epinephrine injection) , an amide local anesthetic containing a vasoconstrictor, is indicated for local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. (rxlist.com)
  • Results Although most respondents reported being likely to choose local anesthetics at less toxic concentrations (including 2% mepivacaine or lidocaine), they were also likely to have similar vasoconstrictor solutions (epinephrine) as the second choice. (bvsalud.org)
  • Propranolol and other nonselective beta-adrenergic blocking agents can inhibit the vasodilatory effect of epinephrine in dental local anesthetic solutions, leading to hypertensive reactions and a concomitant reflex bradycardia. (cdeworld.com)
  • Sensorcaine® (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. (globalrph.com)
  • Lidocaine Hydrochloride (Xylocaine) with Epinephrine - the most common local anesthetic of the amide type used in dentistry for nerve blocking and infiltration technique. (toothnature.com)
  • In adults, an initial dose is 1½-2½ cartridges (1.0-5.0 mL) of 2% Lidocaine HCl with either epinephrine 1:50,000 or 1:100,000 is sufficient to achieve local anesthesia needed. (toothnature.com)
  • It is not totally understood exactly how phentolamine mesylate works, but it appears to be a vasodilator since it only works if the local anesthetic contains a vasoconstrictor like epinephrine. (dndentist.com)
  • Most agents come in two forms: with and without epinephrine adrenaline or other vasoconstrictor that allow the agent to last longer. (contractorprofitzone.com)
  • Epinephrine and neocobefrin are included in most dental anesthetic formulations as vasoconstrictors to keep the anesthetic in the targeting area. (drbicuspid.com)
  • The NCBI reports that many clinicians believe epinephrine in a local anesthetic can cause a "rapid rise in blood pressure and heart rate," though, some studies show that nominal amounts have little to no effect. (colgate.com)
  • Instead, your dentist will opt for another slowing agent in place of epinephrine that does not act as a vasoconstrictor but allows the anesthesia to last longer. (colgate.com)
  • For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities. (pharmacycode.com)
  • Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities. (pharmacycode.com)
  • Topical vasoconstrictors act on alpha-adrenergic receptors in the nasal mucosa, causing vessels to constrict. (medscape.com)
  • They are used in various techniques of local anesthesia such as: Topical anesthesia (surface) Topical administration of cream, gel, ointment, liquid, or spray of anaesthetic dissolved in DMSO or other solvents/carriers for deeper absorption Infiltration Brachial plexus block Epidural (extradural) block Spinal anesthesia (subarachnoid block) Iontophoresis Acute pain may occur due to trauma, surgery, infection, disruption of blood circulation, or many other conditions in which tissue injury occurs. (wikipedia.org)
  • topical anesthetic a local anesthetic applied directly to the area to be anesthetized, usually the mucous membranes or the skin. (thefreedictionary.com)
  • The area is made numb either by the application of local anesthesia i.e. the topical application or by injecting into the concerned area. (identalhub.com)
  • The results of clinical and experimental studies on topical treatment of distal colitis with local anaesthetic agents are summarized. (nih.gov)
  • A topical sympathomimetic amine found in local anesthetic products that is used for nasal decongestion or vasoconstriction during dental procedures. (drugbank.ca)
  • 2. Pharmacology Pharmacology and physiology of local and topical anaesthesia. (up.ac.za)
  • Discuss the available topical anesthetics used in conjunction with local anesthetics in dentistry. (netce.com)
  • Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics. (contractorprofitzone.com)
  • Vasoconstrictors mixed with local anesthetics are used to increase the duration of local anesthesia by constricting the blood vessels, thereby safely concentrating the anesthetic agent for an extended duration, as well as reducing hemorrhage . (wikipedia.org)
  • There is risk of accidental damage to local blood vessels during injection of the local anaesthetic solution. (wikipedia.org)
  • A vasoconstrictor drug such as the adrenaline which causes the local anesthetic effect to last longer as the main effect due to the constriction of the blood vessels. (identalhub.com)
  • In contrast, the primary vasoconstrictor prostanoid TxA 2 is produced in far smaller quantities, primarily by the platelets, and to a lesser extent by some systemic blood vessels ( 54 , 71 ). (physiology.org)
  • This restricts the size of the blood vessels, which allows the numbing agent to remain in effect for longer. (dndentist.com)
  • This is where a vasodilator can come in handy-increasing the size of blood vessels so that the numbing agent can move more rapidly through and out of the system. (dndentist.com)
  • Vasoconstrictors consist of a number of treatments designed to greatly reduce the swelling by causing the affected blood vessels to constrict. (externalhemorrhoidtreatment.net)
  • Vasoconstrictors are known for the light anesthetic effect they have over the blood vessels as well as the relief they provide from discomfort, irritation and itching. (externalhemorrhoidtreatment.net)
  • an agent that causes narrowing of the blood vessels and therefore a decrease in blood flow. (academic.ru)
  • as, the vasoconstrictor nerves, stimulation of which causes constriction of the blood vessels to which they go. (academic.ru)
  • In fact, your mouth contains more blood vessels than many other parts of your body, which makes the absorption of a local anesthetic faster, per the Magazine for Registered Dental Hygienists' . (colgate.com)
  • Subsequently, the administration of the alpha-adrenergic blocking agent phentolamine caused all these values to return to base-line levels. (nih.gov)
  • In studies of experimental colitis a potential antagonism between harmful adrenergic nerves (vasoconstrictor substances and proinflammatory cytokines) and mucosa-protective visceral afferents (antiinflammatory cytokines) in the pathogenesis of colitis is intriguing. (nih.gov)
  • Ephedrine is an adrenergic agent that acts physiologically as a local vasoconstrictor and causes a pronounced stimulation of the central nervous system. (google.com.hk)
  • A alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. (drugbank.ca)
  • Phentolamine, an alpha-adrenergic blocking agent, does not reverse anesthetics themselves. (drbicuspid.com)
  • Properties that distinguish these medications from each other, indications/contraindications for use, the use of vasoconstrictors to prolong anesthesia, utilization of buffering solutions to prevent pain, and potential medical emergencies will be discussed. (netce.com)
  • Intranasal cocaine is used frequently as a local anesthetic during many rhinolaryngologic procedures. (nih.gov)
  • Cocaine is used medically as an excellent local anesthetic agent and powerful vasoconstrictor. (healthcaremagic.com)
  • Synthetic local anesthetics are structurally related to cocaine. (meddic.jp)
  • Other factors that have been described to increase epistaxis risk include surgery, local malignancy and aneurysms, nasal septal deviation and use of drugs, including drugs of abuse, acting on the nasal mucosa e.g. cocaine 15. (rcemlearning.co.uk)
  • Methods One hundred and twenty-four (124) dentists from private clinics in São Luís (Maranhão, Brazil) answered a questionnaire regarding the choice of solutions, selection criteria for local anesthetics and vasoconstrictors, and side effects associated with these substances. (bvsalud.org)
  • is a powerful vasoconstrictor and platelet ______ agent. (brainscape.com)
  • Knowledge of the toxicology and pharmacology of anesthetic agents will maximize the safety of local anesthetic injections. (toothnature.com)
  • Common astringents, hemostatics, and vasoconstrictors used in dentistry as gingival retraction agents are discussed, and recommendations for modification of patient and treatment management are provided. (cdeworld.com)
  • 6,16-18 Mechanico-chemical retraction involves cord that has been impregnated or soaked in astringents, hemostatics, or vasoconstrictors to achieve the clear field necessary for successful fixed prosthodontic impressions. (cdeworld.com)
  • Hence, among other factors, it is important for local anesthetics to show rapid onset of action, provide adequate duration of anesthesia, and be composed by substances (i.e. local anesthetics, vasoconstrictors) with minimal or no systemic toxicity 1-2 . (bvsalud.org)
  • The main mechanism of action proposed for local anesthetics (LAs) is related to the binding of these substances to sodium channels receptors (Na+), leading to the reduction or elimination of the permeability of these ions and interruption of the nervous conduction 3-4 . (bvsalud.org)
  • It is well established that these vasoactive substances play important roles in the local regulation of vascular tone, in both normal physiological and pathophysiological states. (physiology.org)
  • 4. The vasoconstrictor in the local anesthetic makes the heart beat faster but this effect lasts for about 2 min so local anesthesia with adrenaline is avoided in cardiac patients. (identalhub.com)
  • For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential. (drugbank.ca)
  • Vasoconstrictors (e.g. adrenaline) may be administered with local anaesthetic agents. (dressageireland.ie)
  • When anesthetics are used concomitantly with vasoconstrictors, their anesthetic effect is prolonged and the pain threshold increased. (medscape.com)
  • Various procedures in dentistry cannot be made painless without the use of a local anesthetic and also at times the patient is so anxious with the fear of pain during the dental procedure that even if there is no need of an anesthetic injection they would purposely ask for it. (identalhub.com)
  • For purposes of pain therapy, local anesthetic drugs are often given by repeated injection or continuous infusion through a catheter. (meddic.jp)
  • These adverse experiences are generally dose related and due to high plasma levels which may result from overdosage, rapid absorption from the injection site, diminished tolerance, or from unintentional intravascular injection of the local anesthetic solution. (globalrph.com)
  • It is always wise to weigh the risks of anesthetic agents and a vasoconstrictor against the benefits for each patient before using anesthetic injection. (toothnature.com)
  • Objective To evaluate the knowledge of dentists about signs and symptoms that may be indicative of systemic toxicity associated with the use of local anesthetic solutions. (bvsalud.org)
  • Conclusion The group of dentists involved in this study showed limited knowledge about the toxicity of local anesthetics, as well as some inconsistent background over the choice of vasoconstrictors. (bvsalud.org)
  • These anesthetic agents are distributed in concentrations that are appropriate to their toxicity and their anesthesia producing qualities. (doctorspiller.com)
  • The incidence of toxicity to local anesthetics in the dental setting is extremely rare and generally revolve around very unusual patient centered physiologic abnormalities rather than poor anesthetic technique on the part of the dentist. (doctorspiller.com)
  • Onset and duration of action differs among various agents and toxicity from systemic absorption also varies. (howtopace.com)
  • The following table is based on The Handbook of Local Anesthesia (Malamed, S.F.). All carpules of anesthesia except articaine contain 1.8 ml of anesthesia. (doctorspiller.com)
  • Titrating anesthetic agents to a specific bispectral index during general anesthesia in adults (and children over 1 year old) allows the anesthetist to adjust the amount of anesthetic agent to the needs of the patient, possibly resulting in a more rapid emergence from anesthesia. (blogspot.com)
  • A good discussion of this is found on page 4 of this course, and I advise persons who want to know more about the physiology of nerves and local anesthesia to read the entire page, but the specific reference to acid/base balance is found here . (doctorspiller.com)
  • As described later, adequate deep infiltration of local anesthesia along the proposed skin incision blocks these nerves and delivers a large field of anesthesia that is useful for creation of the pocket. (howtopace.com)
  • A direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds. (drugbank.ca)
  • A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion. (drugbank.ca)
  • An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. (drugbank.ca)
  • Prolonged continuous use of Nazivin, like any other vasoconstrictor, can lead to a decrease in the effectiveness of the drug, atrophy, and reversible swelling of the nasal mucosa (drug rhinitis). (remedy-info.com)
  • Some vasoconstrictors (e.g. ephedrine, xylometazoline ) have a rapid effect when applied to mucous membranes and may be used to relieve nasal congestion. (academic.ru)
  • A high percentage of so-called non-traumatic epistaxis is due to local minor trauma to the nasal mucosa e.g. nose picking or rubbing. (rcemlearning.co.uk)
  • Expert author Demetra Logothetis is a dental hygiene educator with 15 years of experience teaching local anesthesia administration. (elsevier.com)
  • Articaine (Astracaine) is a short-acting amide type of local anesthetic with a rapid metabolism. (toothnature.com)
  • This type of local anesthetic is more likely to be converted to water-soluble metabolites in plasma. (pharmacology2000.com)
  • Medications causing vasoconstriction, also known as vasoconstrictors, are one type of medicine used to raise blood pressure . (wikipedia.org)
  • A sympathomimetic agent used in the treatment of hypotension. (drugbank.ca)
  • 6. The method of claim 5 in which the active agent is selected from the group consisting of lidocaine, ripivacaine and mepivacaine. (google.com)
  • 9. The method of claim 6 in which the active agent is mepivacaine. (google.com)
  • Local or intra-articular injections of lidocaine (also called xylocaine or lignocaine), procaine (also known as novocaine), articaine (also called septocaine or ubistesin), bupivacaine (a long-acting anesthetic), and mepivacaine are permitted. (sportsdentistry.info)
  • Other local anesthetic agents in current use include articaine also called septocaine or ubistesin , bupivacaine a long-acting anesthetic , Prilocaine also called Citanest , and mepivacaine also called Carbocaine or Polocaine. (contractorprofitzone.com)
  • It is proposed that the potent vasoconstrictor action of TxA 2 is beneficial in the female in the normal state by acting as a local counterregulatory mechanism to increase vascular tone and BP and defend against hypotension that could result from the multiple estrogen-sensitive local vasodilator mechanisms present in the female vascular wall. (physiology.org)
  • A constant shear stress maintains vascular endothelium homeostasis while perturbed shear stress leads to changes in secretion of vasodilator and vasoconstrictor agents. (elsevier.com)
  • List the most common local anesthetics used in dentistry today, including pharmacologic properties and contraindications. (netce.com)
  • Thus, strategies are required towards improving the knowledge of professionals from private dental clinics regarding local anesthetics and/or vasoconstrictors. (bvsalud.org)
  • There are two main types of local anesthetics available and used in dentistry. (identalhub.com)
  • A safe and effective local anesthesia, which is one of the most frequent and important approaches for controlling the pain in Dentistry, is essential towards achieving the patient care. (bvsalud.org)
  • The use of local anesthetics in dentistry has a long history of efficacy and safety. (netce.com)
  • This course will review the history of local anesthetic use in dentistry and the current group of local anesthetics in use clinically. (netce.com)
  • The most widely used drugs in dentistry today are local anesthetics. (toothnature.com)
  • In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. (contractorprofitzone.com)
  • In dentistry, the most commonly used local anesthetic is lidocaine also called xylocaine or lignocaine , a modern replacement for procaine also known as novocaine. (contractorprofitzone.com)
  • A vasoconstrictor is often added to local anaesthetic solutions used in dentistry to prolong their effectiveness. (academic.ru)
  • Inject the least volume of anesthetic solution that yields effective local anesthesia. (toothnature.com)
  • Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of nerve impulses, thereby effecting local anesthetic action. (drugs.com)
  • Treatment of distal colitis with local anaesthetic agents. (nih.gov)
  • Toxicities and basic principles of local anaesthetic agents. (up.ac.za)
  • During any of the inflammatory process in a place where is this inflammation, local temperature and blood flow are increasing (to fight with disease-causing bacteria), so to get rid of red acne marks, of course, it is best to first remove the cause of the problem - get rid of the disease microbes. (amazonaws.com)
  • They contain vasoconstrictor components that reduce blood flow to the location of inflammation, thereby taking away the redness (and not only in the eyeballs, it's perfectly valid for subcutaneous capillaries as well). (amazonaws.com)
  • This sticks, pencils, gels of local actions should be applied directly to the location of inflammation. (amazonaws.com)
  • They contain vasoconstrictor and anti-inflammatory agents, which reduce the redness and inflammation, removing red acne marks. (amazonaws.com)
  • Although it is recognised that any local inflammation or trauma is likely to result in a nosebleed, the precise mechanisms by which most epistaxis occurs are still poorly understood. (rcemlearning.co.uk)
  • LA drugs are also often combined with other agents such as opioids for synergistic analgesic action. (wikipedia.org)
  • Local anesthetics are drugs that block nerve conduction in the region where they are applied. (thefreedictionary.com)
  • Low doses of local anesthetic drugs can be sufficient so that muscle weakness does not occur and patients may be mobilized. (meddic.jp)
  • With the simultaneous use of other vasoconstrictor drugs increases the risk of side effects. (remedy-info.com)
  • The drug affects the absorption of local anesthetics, slowing it down, lengthens the effect of these drugs. (frankansell.com)
  • Due to the fact that the drug is administered intranasally (in the nose), the simultaneous administration of drugs with a vasoconstrictive effect of a local nature is not recommended. (willmarryforhealthinsurance.com)
  • Ephedrine was the first agent used for this purpose and it has withstood the test o f time: it is the agent against which all others are compared. (scribd.com)
  • The decision to use Lignocaine mixed with adrenalin as a vasoconstrictor agent is at the operator's discretion although it does provide grounds for using larger doses of lignocaine. (howtopace.com)
  • In order to silence local nervous reflexes, the mucosa was treated topically with 2% lidocaine gel. (nih.gov)
  • In patients suffering from the various forms of HMS, the local anesthetic will produce numbness, but it may be of insufficient intensity or duration to complete the dental procedure without repeated injections. (doctorspiller.com)
  • The onset of anesthesia and the duration of anesthesia are proportional to the volume and concentration (i.e., total dose) of local anesthetic used. (rxlist.com)
  • When using local anesthetics, dentists make their choices to achieve profound anesthesia based on body weight of the patient and duration of a dental procedure. (toothnature.com)
  • Other studies have emphasized the importance of neutrophils for causing damage to the colon epithelium (neutrophil hypothesis) and local anaesthetics have potent effects on several steps of the inflammatory response in addition to the nervous blockade. (nih.gov)
  • Reduce systemic absorption rate due to the addition of vasoconstrictors with local anesthetics is most typically noted with shorter-acting, less lipid-soluble and less potent agents. (pharmacology2000.com)
  • Surface anesthesia also facilitates some endoscopic procedures such as bronchoscopy (visualization of the lower airways) or cystoscopy (visualization of the inner surface of the bladder) Edema of tongue, pharynx and larynx may develop as a side effect of local anaesthesia. (wikipedia.org)
  • Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents. (bireme.br)
  • BACKGROUND: Whilst carrying out dental procedures under general anaesthesia (GA), practitioners routinely give local anaesthetics (LA) intraoperatively to children. (bireme.br)
  • OBJECTIVES: To assess the effects of intraoperative local anaesthesia for reducing postoperative pain following general anaesthesia for dental treatment in children and young people aged 17 years or younger. (bireme.br)
  • It remains the first-line agent in obstetric anaesthesia as it does not affect the fetus adversely, but it cannot be relied upon to be 100% successful and other agents must be considered when it is inadequate. (scribd.com)
  • The development of procaine, a much safer agent, in 1904 by Einhorn enabled spinal anaesthesia to gain popularity. (scribd.com)
  • Cardiac / heart dysrhythmias are well recognized during oral surgery, especially during extractions or pre-prosthetic surgery under local anaesthesia. (myhealth.gov.my)
  • Administering of applicable local anaesthesia as appropriate to the scope of the profession of oral hygiene. (up.ac.za)
  • Dental anesthesia or dental anaesthesia is a field of anesthesia that includes local anesthetics , sedation , and general anesthesia. (contractorprofitzone.com)
  • Even though sedation is available, the operator should develop and master the technique of local anaesthesia as one may occasionally come across a patient where sedation is not feasible or safe. (howtopace.com)
  • Yet, the treatment for sympathetically maintained pain [SMP] often involves local anesthetic or regional blockade of the efferent sympathetic supply to the affected area. (uthscsa.edu)
  • However due to the anesthetic and vasoconstrictor action, these signs are minimal. (healthcaremagic.com)
  • agent with vasoconstrictor action for local use in ENT practice. (remedy-info.com)
  • Describe the basic neurophysiologic mechanisms of action of local anesthetics. (netce.com)
  • Analyze the action of buffering solutions and anesthetic reversal agents. (netce.com)
  • Which of the following is not a theory for local anesthetic action? (dentaldevotee.com)
  • Of the following local anesthetics, which has intrinsic vasoconstrictive action? (dentaldevotee.com)
  • For all practical purposes, lignocaine is the preferred local anesthetic - it has rapid onset of action, good safety profile and provides adequate time coverage for the procedure. (howtopace.com)
  • A local anesthetic (LA) is a medication that causes absence of pain sensation. (wikipedia.org)
  • In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general anesthetic. (wikipedia.org)
  • Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent. (drugs.com)
  • A local anesthetic ( LA ) is a drug that causes reversible local anesthesia, generally for the aim of having a local analgesic effect, that is, inducing absence of pain sensation, although other local senses are often affected as well. (meddic.jp)
  • Reactions to Sensorcaine (bupivacaine HCl) are characteristic of those associated with other amide-type local anesthetics. (globalrph.com)
  • Compare and contrast ester-type and amide-type local anesthetics. (netce.com)
  • Amide-type local anesthetics undergo hepatic biotransformation involving hydroxylation and N-dealkylation catalyzed by the cytochrome P450 drug metabolizing system. (pharmacology2000.com)
  • Diagnostic tests such as bone marrow aspiration, lumbar puncture (spinal tap) and aspiration of cysts or other structures are made to be less painful upon administration of local anesthetic before insertion of larger needles. (wikipedia.org)
  • Before delving in to actual technical details, it is necessary to understand the nerve supply of the region as proper anatomic knowledge facilitates efficient administration of local anesthetic. (howtopace.com)
  • 1K1C atenolol rats showed reduced hypertensive responses to both vasoconstrictors. (bireme.br)
  • Finger blood flow and the vasoconstrictor responses to the cold pressor test and to a deep breath were measured to assure the efficacy of the block. (uthscsa.edu)
  • Results: Finger blood flow rose to 370% of the pre-block control value, and vasoconstrictor responses were markedly attenuated by the block. (uthscsa.edu)
  • When it is used on specific nerve pathways ( local anesthetic nerve block ), paralysis (loss of muscle power) also can be achieved. (wikipedia.org)
  • [2] However, the specific mechanisms for generating an increased intracellular concentration of calcium depends on the vasoconstrictor. (wikipedia.org)
  • The invention discloses methods and compositions for enhanced skin concentration of iontophoretic delivered active agents. (google.com)
  • The compositions are pharmaceutically acceptable compositions for iontophoretic delivery which comprise a skin concentration enhancing amount of a vasoconstrictor and active agent. (google.com)
  • Methods comprise adding a skin concentration enhancing amount of a vasoconstrictor to an active agent and delivering by iontophoresis. (google.com)
  • More specifically, the invention relates to methods and compositions for enhancing skin concentration of iontophoretic delivered active agents. (google.com)
  • The process is one wherein the rate of delivery is a function of current, active agent concentration, and presence of other ions. (google.com)
  • Studies of lidocaine metabolism following intravenous bolus injections have shown that the elimination half-life of this agent is typically 1.5 to 2.0 hours. (drugs.com)
  • Generally there are two forms of local anesthesia injections which depend on the method of insertion of the needle by the dentist. (identalhub.com)
  • Avoid injections into the same site over the prolonged period due to the restriction of blood flow influenced by vasoconstrictor agents. (toothnature.com)
  • An anti-oxidant by the name of sodium metabisulphite is used to prevent the oxidation of the anesthetic agent and hence increase the shelf life of the vasoconstrictor. (identalhub.com)
  • Written by a dental hygienist for dental hygienists, Local Anesthesia for the Dental Hygienist helps you learn the safe and effective administration of local anesthesia. (elsevier.com)
  • Coverage is tailored to fit the role and needs of the dental hygienist and promotes patient-centered care by integrating discussions of the Human Needs Paradigm with complete instructions for local anesthesia administration. (elsevier.com)
  • This course will provide the licensed dental hygienist with initial didactic and clinical laboratory components necessary to perform local anesthesi. (umaryland.edu)
  • Could you provide an example of "ideal" documentation by a dental hygienist after local anesthesia is used. (dimensionsofdentalhygiene.com)
  • Local Anesthesia for the Dental Hygienist, 2nd Edition, provides complete instructions for the safe and effective administration of local anesthesia. (elsevierhealth.com)
  • A dental hygienist who holds a local anesthesia permit shall complete 3 of the required 20 hours of continuing education in courses related to the administration of local anesthesia, including pharmacology or other related courses. (contractorprofitzone.com)
  • However, many anaesthetists, surgeons, patients and nurses believe that it is safer to perform major surgeries under local anesthesia than general anesthesia. (wikipedia.org)
  • Local anesthesia should be used when the patient is undergoing implantation under general anesthesia as this permits lower levels of GA medications and facilitates smooth recovery and most importantly provides post operative pain relief - which may be a significant issue in children. (howtopace.com)
  • Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. (wikipedia.org)
  • It was designed to identify all the randomized clinical trials (RCTs) published in the last 30 years, which assessed whether the use of LA with VC agents in dental treatment produces a significant increase/decrease in hemodynamics in patients with known history of Hypertension and/or Coronary disease. (bvsalud.org)
  • Describe the use and various classifications of chemical agents in clinical practice for fixed prosthodontic impressioning. (cdeworld.com)