The transference of a part of or an entire liver from one human or animal to another.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Pathological processes of the LIVER.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The transference of a kidney from one human or animal to another.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Tumors or cancer of the LIVER.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The transference of a heart from one human or animal to another.
Transplantation of an individual's own tissue from one site to another site.
Prospective patient listings for appointments or treatments.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The transference of either one or both of the lungs from one human or animal to another.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Elements of limited time intervals, contributing to particular results or situations.
Excision of all or part of the liver. (Dorland, 28th ed)
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Repair or renewal of hepatic tissue.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The return of a sign, symptom, or disease after a remission.
Transference of an organ between individuals of the same species or between individuals of different species.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Veins which drain the liver.
The circulation of BLOOD through the LIVER.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The transference of a pancreas from one human or animal to another.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
The period following a surgical operation.
A dead body, usually a human body.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Operation for biliary atresia by anastomosis of the bile ducts into the jejunum or duodenum.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
A bile pigment that is a degradation product of HEME.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).
Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Surgical portasystemic shunt between the portal vein and inferior vena cava.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Transference of fetal tissue between individuals of the same species or between individuals of different species.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Surgical venous shunt between the portal and systemic circulation to effect decompression of the portal circulation. It is performed primarily in the treatment of bleeding esophageal varices resulting from portal hypertension. Types of shunt include portacaval, splenorenal, mesocaval, splenocaval, left gastric-caval (coronary-caval), portarenal, umbilicorenal, and umbilicocaval.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Transplantation between animals of different species.
Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)
Disease having a short and relatively severe course.
Any surgical procedure performed on the biliary tract.
Surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Accumulation or retention of free fluid within the peritoneal cavity.
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC, also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
The period during a surgical operation.
Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.
Planning for the equitable allocation, apportionment, or distribution of available health resources.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)
A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Partial or total replacement of the CORNEA from one human or animal to another.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Experimentally induced tumors of the LIVER.
Societal or individual decisions about the equitable distribution of available resources.
Extracts of liver tissue containing uncharacterized specific factors with specific activities; a soluble thermostable fraction of mammalian liver is used in the treatment of pernicious anemia.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
A malignant tumor arising from the epithelium of the BILE DUCTS.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
The study of chance processes or the relative frequency characterizing a chance process.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Congenital cystic dilatation of the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). It consists of 2 types: simple Caroli disease is characterized by bile duct dilatation (ectasia) alone; and complex Caroli disease is characterized by bile duct dilatation with extensive hepatic fibrosis and portal hypertension (HYPERTENSION, PORTAL). Benign renal tubular ectasia is associated with both types of Caroli disease.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Tumors or cancer of the BILE DUCTS.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
Therapy with two or more separate preparations given for a combined effect.
The measurement of an organ in volume, mass, or heaviness.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A PREDNISOLONE derivative with similar anti-inflammatory action.
The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Formation and development of a thrombus or blood clot in the blood vessel.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
A group of diseases related to a deficiency of the enzyme ARGININOSUCCINATE SYNTHASE which causes an elevation of serum levels of CITRULLINE. In neonates, clinical manifestations include lethargy, hypotonia, and SEIZURES. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ATAXIA, behavioral changes, and DYSARTHRIA. (From Menkes, Textbook of Child Neurology, 5th ed, p49)
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

Predicting bone loss following orthotopic liver transplantation. (1/6573)

BACKGROUND: Hepatic osteodystrophy occurs in the majority of patients with advanced chronic liver disease with the abnormalities in bone metabolism accelerating following orthotopic liver transplantation (OLT). AIMS: To examine changes in bone mineral density (BMD) following OLT and to investigate factors that lead to bone loss. METHODS: Twelve patients had BMD (at both the lumbar spine (LS) and femoral neck (FN)) and biochemical markers measured preoperatively and for 24 months following OLT. RESULTS: BMD was low in 75% of patients prior to OLT and decreased significantly from baseline at the LS at three months and the FN at six months. BMD began to increase thereafter at both sites, approaching baseline values at the LS by 12 months. Bone formation markers, osteocalcin and procollagen type I carboxy propeptide, decreased immediately post-OLT, with a concomitant increase seen in the resorption markers pyridinoline and deoxypyridinoline. This resulted in a negative uncoupling index early post-OLT, that rebounded to positive values after six months. There was a significant correlation between the change in the uncoupling index between six and three months which preceded the increase in BMD at 12 months. The decrease in BMD recorded early post-OLT correlated with vitamin D levels at three months. CONCLUSIONS: Results suggest that increased resorption and inadequate formation are the major contributors to additional bone loss following OLT. Non-invasive biochemical markers precede later changes in BMD in this patient group following OLT and may have a role in investigating and planning intervention strategies to prevent bone loss in future studies.  (+info)

Performance and specificity of monoclonal immunoassays for cyclosporine monitoring: how specific is specific? (2/6573)

BACKGROUND: Immunoassays designed for the selective measurement of cyclosporin A (CsA) inadvertently show cross-reactivity for CsA metabolites. The extent and clinical significance of the resulting overestimation is controversial. A comprehensive assessment of old and new methods in clinical specimens is needed. METHODS: In a comprehensive evaluation, CsA was analyzed in 145 samples with the new CEDIA assay and compared with the Emit assay with the old and new pretreatments, the TDx monoclonal and polyclonal assays, the AxSYM, and HPLC. All samples were from patients with liver and/or kidney transplants. RESULTS: The CEDIA offered the easiest handling, followed by the AxSYM, which showed the longest calibration stability. The TDx monoclonal assay provided the lowest detection limit and the lowest CVs. The mean differences compared with HPLC were as follows: Emit, 9-12%; CEDIA, 18%; AxSYM, 29%; and TDx monoclonal, 57%. The CycloTrac RIA paralleled the Emit results. In contrast to the mean differences, substantial (>200%) and variable overestimations of the CsA concentration were observed in individual patient samples. Metabolic ratios, estimates of the overall concentrations of several cross-reacting metabolites (nonspecific TDx polyclonal/specific reference method), correlated with the apparent biases of the various monoclonal assays. Metabolic ratios varied up to 10-fold, which translated into biases for individual samples between -7% and +174%. The higher the cross-reactivity of an assay was, the higher was the range of biases observed. The interindividual differences markedly exceeded other factors of influence (organ transplanted, hepatic function). CONCLUSION: Because assay bias cannot be predicted in individual samples, substantially erratic CsA dosing can result. The specificity of CsA assays for parent CsA remains a major concern.  (+info)

Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients. (3/6573)

AIM: To identify cytomegalovirus (CMV) infection in liver transplant recipients by polymerase chain reaction (PCR) techniques and to separate the cases in which CMV related disease will occur, for whom treatment is indicated, from those in whom infection will remain innocuous. METHODS: The combination of qualitative and semiquantitative PCR of serum and urine was assessed to determine whether these assays can identify those at risk of CMV related disease and compared their performance with conventional approaches to diagnosis. RESULTS: Qualitative PCR of serum had superior specificity, sensitivity, and positive and negative predictive values compared with urine DEAFF (detection of early antigen fluorescent foci) and PCR of urine. All episodes of CMV related disease were associated with the presence of CMV DNA by PCR in serum or urine; CMV was detected before clinical onset in 70% and 60% of cases, respectively. The period over which CMV DNA could be detected was not correlated with CMV related disease. Both peak viral load and cumulative viral load estimated using a semiquantitative PCR method on serum samples positive by the qualitative method could be used to distinguish asymptomatic infection from CMV related disease with 100% specificity and sensitivity. In contrast semiquantitative PCR of urine was of little value. CONCLUSIONS: An approach based on PCR testing with a combination of qualitative and subsequently semiquantitative serum samples would improve the diagnosis of CMV infection and aid identification of those patients at risk of CMV related disease, allowing treatment to be targeted specifically.  (+info)

Primary adult liver transplantation under tacrolimus: more than 90 months actual follow-up survival and adverse events. (4/6573)

The introduction of tacrolimus has shown decreased rates of acute and steroid-resistant rejection after liver transplantation (LTx). The aim of the present study is to examine the long-term efficacy and safety of tacrolimus in primary liver transplant recipients. The first 121 consecutive adults (aged >16 years) who underwent primary LTx at a single center from August 1989 to February 1990 were followed up until August 1997. The mean follow-up was 93.2 +/- 1.2 months (range, 90.5 to 96.5 months). Patient survival, graft survival, rate of rejection, and adverse events were examined. The actual 7-year patient survival rate was 67.8%, and the graft survival rate was 63.6%. Infections, recurrence of disease, de novo malignancies, and cardiovascular events constituted the main causes of graft loss and death in the long term. Graft loss related to acute or chronic rejection was rare. The rate of acute rejection beyond 2 years was approximately 3% per year, and most rejections were steroid responsive. Approximately 70% of the patients received only tacrolimus after 1 year. Four patients developed end-stage renal disease, and 2 patients underwent kidney transplantation. Hyperkalemia and hypertension were observed in one third of the patients. New-onset insulin-dependent diabetes mellitus was observed in 9% and 13% of the patients at the 1-year and 7-year follow-up, respectively. Seven patients developed de novo malignancies, including two skin malignancies. Six patients developed posttransplantation lymphoproliferative disorder during the entire follow-up period. Actual patient and graft survival at 7 years was excellent, and few adverse events developed after the first year. Graft loss from acute or chronic rejection was rare under tacrolimus, and approximately 70% of the patients were steroid free on tacrolimus monotherapy after the first year after LTx.  (+info)

Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders. (5/6573)

Early diagnosis of Epstein-Barr Virus (EBV)-associated posttransplant lymphoproliferative disease (PTLD) is important because many patients respond to reduction in immunosuppression, especially if PTLD is detected at an early stage. Previous studies have found elevated EBV DNA levels in blood from patients with PTLD, but these assays required isolation of cellular blood fractions and quantitation. We evaluated the presence of cell-free EBV DNA in serum from solid-organ transplant recipients as a marker for PTLD. Five of 6 transplant recipients with histopathologically documented PTLD had EBV DNA detected in serum at the time of diagnosis (sensitivity = 83%), compared with 0 of 16 matched transplant recipients without PTLD (specificity = 100%) (P < 0.001 [Fisher's exact test]). Furthermore, EBV DNA was detected in serum 8 and 52 months prior to the diagnosis of PTLD in two of three patients for whom stored sera were analyzed. Detection of EBV DNA in serum appears to be a useful marker for the early detection of PTLD in solid-organ transplant recipients. Further studies to define the role of such assays in evaluating solid-organ transplant patients at risk for PTLD are warranted.  (+info)

Hepatitis C virus recurrence after liver transplantation. (6/6573)

Cirrhosis due to hepatitis C virus (HCV) is now the most common indication of liver transplantation in Western Europe and the United States. In the absence of effective prophylaxis, recurrent HCV infection is almost inevitable. Though the natural history and intermediate term outcome of recurrent HCV are now better documented, those factors which may influence the recurrence of hepatitis and consequent progression of graft disease remain unclear. Interferon (IFN) as a sole agent for the treatment of recurrent infection has proved unsatisfactory. Early intervention with a combination of IFN and ribavirin seems promising, and this approach may prevent or delay progression of HCV related graft disease after liver transplantation.  (+info)

Split liver transplantation. (7/6573)

OBJECTIVE: This study reviews the indications, technical aspects, and experience with ex vivo and in situ split liver transplantation. BACKGROUND: The shortage of cadaveric donor livers is the most significant factor inhibiting further application of liver transplantation for patients with end-stage liver disease. Pediatric recipients, although they represent only 15% to 20% of the liver transplant registrants, suffer the greatest from the scarcity of size-matched cadaveric organs. Split liver transplantation provides an ideal means to expand the donor pool for both children and adults. METHODS: This review describes the evolution of split liver transplantation from reduced liver transplantation and living-related liver transplantation. The two types of split liver transplantation, ex vivo and in situ, are compared and contrasted, including the technique, selection of patients for each procedure, and the most current results. RESULTS: Ex vivo splitting of the liver is performed on the bench after removal from the cadaver. It is usually divided into two grafts: segments 2 and 3 for children, and segments 4 to 8 for adults. Since 1990, 349 ex vivo grafts have been reported. Until recently, graft and patient survival rates have been lower and postoperative complication rates higher in ex vivo split grafts than in whole organ cadaveric transplantation. Further, the use of ex vivo split grafts has been relegated to the elective adult patient because of the high incidence of graft dysfunction (right graft) when placed in an emergent patient. Reasons for the poor function of ex vivo splits except in elective patients have focused on graft damage due to prolonged cold ischemia times and rewarming during the long benching procedure. In situ liver splitting is accomplished in a manner identical to the living donor procurement. This technique for liver splitting results in the same graft types as in the ex vivo technique. However, graft and patient survival rates reported for in situ split livers have exceeded 85% and 90%, respectively, with a lower incidence of postoperative complications, including biliary and reoperation for bleeding. These improved results have also been observed in the urgent patient. CONCLUSION: Splitting of the cadaveric liver expands the donor pool of organs and may eliminate the need for living-related donation for children. Recent experience with the ex vivo technique, if applied to elective patients, results in patient and graft survival rates comparable to whole-organ transplantation, although postoperative complication rates are higher. In situ splitting provides two grafts of optimal quality that can be applied to the entire spectrum of transplant recipients: it is the method of choice for expanding the cadaver liver donor pool.  (+info)

Beta-glucan reflects liver injury after preservation and transplantation in dogs. (8/6573)

Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion.  (+info)

TY - JOUR. T1 - Portal vein grafts in hepatic transplantation. AU - Shaw, B. W.. AU - Iwatsuki, S.. AU - Bron, K.. AU - Starzl, T. E.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Confirmation of patency of the portal vein by either ultrasound or angiography is a routine part of the evaluation of patients being considered for hepatic transplantation. Complete thrombosis of the portal vein usually has been viewed as precluding successful orthotopic hepatic replacement. In addition, some pediatric patients present with extremely small portal veins which, although patent, have proved to be thick walled and sclerotic. Our recent experience has shown that, in both of these situations, successful and complete revascularization of hepatic allografts is quite feasible by using a vein graft to ensure adequate portal venous flow.. AB - Confirmation of patency of the portal vein by either ultrasound or angiography is a routine part of the evaluation of patients being considered for hepatic transplantation. Complete ...
Since the 1960 s, with the successful development of liver transplantation, it has become an important method for the treatment of patients with end-stage liver disease.Biliary atresia1 is the most frequent causes of pediatric end-stage liver disease,.The morbidity of congenital biliary atresia is 1/8000-18, 0002 ,which influence the patients overall growth and development situation. The rising of living donor liver transplantation has provide children with the chance of a timely treatment since the 1980 s, It is no doubt that pediatric liver transplantation is facing with many complications, including the most importance of neurocognitive development .Now the researches of neurological complications is less .According to statistics, the incidence of neurological complications after pediatric liver transplantation was 8% - 46% . So it is necessary to research the neurological complications and brain protection strategy .Previous studies have studied that some anaesthetic have uncertain affect ...
TY - JOUR. T1 - Living-related liver transplantation in children. T2 - The Parisian strategy to safely increase organ availability. AU - Révillon, Y.. AU - Michel, J. L.. AU - Lacaille, F.. AU - Sauvat, F.. AU - Farges, O.. AU - Belghiti, J.. AU - Rengeval, A.. AU - Jouvet, P.. AU - Sayegh, N.. AU - Sarnacki, S.. AU - Jan, D.. PY - 1999/5. Y1 - 1999/5. N2 - Purpose: The aim of the authors was to report their experience with living related liver transplantation (LRLT) in children, particularly focusing on the safety of the two-center Parisian strategy. Methods: The records of donors and recipients of 26 pediatric living-related donor liver transplantations performed between November 1994 and March 1998 were reviewed retrospectively. Donors were assessed 1 year after transplantation for medical and overall status. Results: Indications for LRLT included biliary atresia (n = 18), Bylers disease (n = 5), alpha-1-antitrypsin deficiency (n = 1), Alagille syndrome (n = 1), and undefined cirrhosis ...
Pediatric Liver Transplant Surgery Hospital in India. Global Hospitals India is the most active pediatric liver transplant hospital in India and has performed many succesful pediatric liver transplantation in India. Global Hospitals India has performed types of pediatric liver transplant like, Deceased donor / cadaveric donor whole liver transplant, Split-liver transplant, Living donor liver transplant, Domino liver transplant , Auxiliary liver transplant in India
TY - JOUR. T1 - Blood Cell Salvage and Autotransfusion Does Not Worsen Oncologic Outcomes Following Liver Transplantation with Incidental Hepatocellular Carcinoma. T2 - A Propensity Score-Matched Analysis. AU - Ivanics, Tommy. AU - Shubert, Christopher R.. AU - Muaddi, Hala. AU - Claasen, Marco P.A.W.. AU - Yoon, Peter. AU - Hansen, Bettina E.. AU - McCluskey, Stuart A.. AU - Sapisochin, Gonzalo. N1 - Publisher Copyright: © 2021, Society of Surgical Oncology.. PY - 2021. Y1 - 2021. N2 - Background: Intraoperative blood cell salvage and autotransfusion (IBSA) during liver transplantation (LT) for hepatocellular carcinoma (HCC) is controversial for concern regarding adversely impacting oncologic outcomes. Objective: We aimed to evaluate the long-term oncologic outcomes of patients who underwent LT with incidentally discovered HCC who received IBSA compared with those who did not receive IBSA. Methods: Patients undergoing LT (January 2001-October 2018) with incidental HCC on explant pathology were ...
Evolution of liver transplantation. Hepatology (1982) 19.54 FK 506 for liver, kidney, and pancreas transplantation. Lancet (1989) 13.70 A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet (1984) 10.33 Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology (1993) 8.76 Orthotopic liver transplantation in ninety-three patients. Surg Gynecol Obstet (1976) 8.11 The use of cyclosporin A and prednisone in cadaver kidney transplantation. Surg Gynecol Obstet (1980) 7.40 The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet (1967) 7.24 Fifteen years of clinical liver transplantation. Gastroenterology (1979) 7.19 Venous bypass in clinical liver transplantation. Ann Surg (1984) 7.04 Liver transplantation with use of cyclosporin a and prednisone. N Engl J Med (1981) 6.95 The many faces of multivisceral transplantation. Surg Gynecol ...
Absence of a normal left extrahepatic portal vein is considered to be a contraindication to left lobe living-related liver transplantation. This report is of a successful case of living- related liver transplantation using a left lobe procured in a patient presenting with an absent horizontal segment of the left extrahepatic vein. ...
Ojo, A, Held, P, Port, F. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. vol. 349. 2003. pp. 931-40. Charlton, M., Wall, W, Ojo, A. Report of the First International Liver Transplantation Society Expert Panel Consensus Conference on Renal Insufficiency in Liver Transplantation. Liver Transplant. vol. 15. 2009. pp. S1-S34. Sharma, S, Gurakar, A, Jabbour, N. Biliary strictures following liver transplantation; past, present and preventive strategies. Liver Transplant. vol. 14. 2008. pp. 759-69. Londono, M, Balderramo, D, Cardenas, A. Management of biliary complications after orthotopic liver transplantation: the role of endoscopy. World J Gastroenterol. vol. 14. 2008. pp. 493-7. Watt, K, Pedersen, R, Kremers, W. Long-term probability of and morality from de novo malignancy after liver transplantation. Gastroenterology. vol. 137. 2009. pp. 2010-17. Watt, K, Pedersen, Kremers, W. Evolution of causes and risk factors for mortality post-liver transplant: ...
Abstract:. Background. Liver transplantation is the standard of care for the treatment of liver failure worldwide, yet millions of people living in sub-Saharan Africa remain without access to these services. South Africa (SA) has two liver transplant centres, one in Cape Town and the other in Johannesburg, where Wits Donald Gordon Medical Centre (WDGMC) started an adult liver transplant programme in 2004.. Objectives. To describe the outcomes of the adult liver transplant programme at WDGMC.. Methods. This was a retrospective review of all adult orthotopic liver transplants performed at WDGMC from 16 August 2004 to 30 June 2016 with a minimum follow-up of 6 months. The primary outcome was recipient and graft survival and the effect of covariates on survival. Kaplan-Meier survival analysis included all adults who underwent their first transplant for end-stage liver disease (ESLD) (N=275). Proportional hazards regression analysis using hazard ratios (HRs) was conducted to determine which ...
1. Brown RS. Hepatitis C and liver transplantation. Nature. 2005 ;436:973-8 2. Davis GL, Albright JE, Cook SF, Rosenberg DM. Projecting future complications of chronic hepatitis C in the United States. Liver Transpl. 2003 ;9:331-8 3. El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology. 2004 ;127:S27-34 4. Wiesner RH, Sorrell M, Villamil F, the International Liver Transplantation Society Expert Panel. Report of the first international liver transplantation society expert panel consensus conference on liver transplantation and hepatitis C. Liver Transpl. 2003 ;9:S1-S9 5. Vargas HE, Rodriguez-Luna H. Management of hepatitis C virus infection in the setting of liver transplantation. Liver Transpl. 2005 ;11:479-89 6. Charlton M. Liver biopsy, viral kinetics, and the impact of viremia on severity of hepatitis C virus recurrence. Liver Transpl. 2003 ;9:S58-S62 7. Chopra KB, Demetris AJ, Blakolmer K, Dvorchik I, Laskus T, Wang LF, Araya VR, Dodson F, Fung JJ, ...
TY - JOUR. T1 - Pediatric liver transplantation using left hepatic segments from living related donors. T2 - Surgical experience in 100 recipients at Saint-Luc University Clinics. AU - Darwish, Ahmed A.. AU - Bourdeaux, Christophe. AU - Kader, Hesham A.. AU - Janssen, Magda. AU - Sokal, Etienne. AU - Lerut, Jan. AU - Ciccarelli, Olga. AU - Veyckemans, Francis. AU - Otte, Jean Bernard. AU - Goyet, Jean De Ville De. AU - Reding, Raymond. PY - 2006/5. Y1 - 2006/5. N2 - Living-related liver transplantation was developed in the context of deceased donor organ shortage, which is particularly acute for pediatric recipients. This retrospective study analyzes the surgical technique and complications in the first 100 pediatric liver transplantation using left segmental liver grafts from living donors, performed at Saint-Luc University Clinics between July 1993 and April 2002. Pre-operative evaluation in donors and recipients, analysis of the surgical technique, and postoperative complications were ...
TY - JOUR. T1 - Hepatic protein synthesis rate of liver specimens as a predictor of viability in rat cold ischemia liver transplantation model. AU - Matsui, Yoshifumi. AU - Asano, Takehide. AU - Nakagohri, Toshio. AU - Yokoro, Yoshiharu. AU - Kainuma, Osamu. AU - Kenmochi, Takashi. AU - Isono, Kaich. PY - 1997/11. Y1 - 1997/11. N2 - Background/Aims: We have previously reported that the hepatic protein synthesis rate, calculated as the uptake rate of L-[4.5 3H] leucine by the fraction during a 10-min incubation of a 16-G needle biopsy specimen of liver tissue, represents a high level of liver function and is therefore useful for evaluating liver function. We investigated the hepatic protein synthesis rate level in a pretransplant liver to learn if it might predict the outcome in a rat orthotopic liver transplantation model. Methods: Grafts were stored, liver specimens were obtained using a 21-G Chiba type II skinny needle, and the hepatic protein synthesis rate was calculated. Subsequently, liver ...
BACKGROUND & AIMS: Patients undergoing liver transplantation have complex changes in their hemostatic system, and the net effect of these changes appears a rebalanced hemostatic profile. Recently, a process called NETosis, in which a neutrophil expels DNA and proteins that form a web-like structure, has been described as a mechanism of pathogen entrapment. Increasing evidence suggests a pivotal role for neutrophil extracellular traps (NETs), and their main component cell-free DNA in activation of coagulation. As liver transplantation is associated with substantial (hepatocyte) cell death and intrahepatic neutrophil accumulation, NETs might play an important role in the hemostatic balance during liver transplantation. Here, we determined markers for NETs in plasma of patients undergoing a liver transplantation and examined their association with activation of coagulation.. METHODS: Markers for NETs and markers for activation of coagulation were determined in serial plasma samples taken from ...
govind ram liver transplant consultant of india support group provides information on liver transplant in india, cost of liver transplant, liver diseases, liver transplant, pre-transplant preparation, peri or post transplant care of liver recipient and liver donor, cadaver organ donation,cadaver liver donation, etc. by the most experienced liver transplant coordinator Anshu Gupta in india.,Complete Medical Guide to Organ donation, Organ Transplant, Multi-Organ Transplant,Gastroenterology,Hepatology,GI Surgery,, Liver Cirrhosis,liver diseases,Liver Operation, Liver Specialist,liver surgery,Liver Transplant India, Liver Transplant in India, Liver Transplant Surgeon, Liver Transplantation,Gastrointestinal Surgery,Support Group, Liver Transplant Consultant of India,Govind Ram, Dr Subash Gupta,Anshu Gupta,Liver Transplant India, Liver Transplant,Gastroenterology,Hepatology,GI Surgery,, Liver Cirrhosis,liver diseases,Liver Operation, Liver Specialist,liver surgery Liver Transplant, liver transplant
Abstract 18. Living related liver transplantation now has a history of almost ten years. Although survival of both graft and patients appears good these data are based mainly on historic controls and comparisons between different centers. We reviewed the results of all children (,16 yr.) receiving their first liver transplant at a single center between 1990 and 1997. The recipients of living related liver allografts (LRLT) were compared to those receiving allografts from cadaveric donors (CadLT), and to the sub-group of recipients receiving reduced-size liver transplants (RSCLT) from cadaveric donors. There were 170 primary orthotopic liver transplants in pediatric patients during this period of which 29 were LRLT. Of the 141 CadLT patients 43 received RSCLT. Post-operative care, including immunosuppression, was the same for both groups. The groups receiving cadaveric and living related allografts were different in terms of age at transplant (median 1.45 v 0.86 yr. respectively, p=0.045) and ...
TY - JOUR. T1 - Adult liver transplantation in the USA. AU - Alqahtani, Saleh Ali. AU - Larson, Anne M.. PY - 2011. Y1 - 2011. N2 - Purpose of review: To provide the nontransplant clinician with a basic understanding of the liver transplant process. Recent findings: Since its inception, the technique of liver transplantation and patient management has evolved considerably. We present an up-to-date overview of the evaluation of the transplant recipient and the listing and timing of transplant. We conclude with a brief summary of long-term complications, which should be considered when caring for the posttransplant patient. Summary: Liver transplantation is the only definitive treatment option for patients dying of liver failure. The growing population of patients with liver disease means that more transplants will be performed. As these patients now live longer lives, it is crucial that clinicians have a basic understanding of the process and outcomes.. AB - Purpose of review: To provide the ...
TY - JOUR. T1 - Longitudinal study of cognitive and academic outcomes after pediatric liver transplantation. AU - Sorensen, Lisa G.. AU - Neighbors, Katie. AU - Martz, Karen. AU - Zelko, Frank. AU - Bucuvalas, John C.. AU - Alonso, Estella M.. N1 - Funding Information: Supported by the National Institute of Child Health and Human Development ( R01 HD045694 ) and the National Institute of Diabetes and Digestive and Kidney Diseases ( U01 DK061693 ). The sponsoring agencies were not involved in the collection, analysis, or interpretation of data or the generation of the report. The authors declare no conflict of interest. PY - 2014/7. Y1 - 2014/7. N2 - Objective To determine the evolution of cognitive and academic deficits and risk factors in children after liver transplantation. Study design Patients ≥2 years after liver transplantation were recruited through Studies of Pediatric Liver Transplantation. Participants age 5-6 years at Time 1 completed the Wechsler Preschool and Primary Scale of ...
de Ville de Goyet, J ; Reding, Raymond ; Lerut, Jan ; Sokal, Etienne ; Janssen, M. ; et. al. Paediatric orthotopic liver transplantation: lessons from a 532 transplant single centre experience with 532 transplants in 446 children.. In: Acta gastro-enterologica Belgica, Vol. 62, no. 3, p. 290-4 (1999 ...
Until recently, HIV infection was considered as a contraindication for liver transplantation. A dramatic improvement in survival of HIV patients have been observed since the advent of new antiviral treatments against HIV including antiproteases. However an important proportion of patients with HCV-HIV coinfection are suffering from life-threatening liver disease due to HCV infection. Liver transplantation may be considered in this particular group of patients.. The ideal timing for the indication of liver transplantation during HIV disease and during the course of HCV liver disease needs to be defined. Liver transplantation in this particular group of patients raised several questions : a) the role of HIV infection on prevalence and severity of HCV recurrence after transplantation ; b) the role of liver transplantation and immunosuppression on HIV disease ; c) drug interactions between immunosuppressive agents and antiproteases ; d) immunological follow-up and quality of life of these patients. ...
TY - JOUR. T1 - Intrahepatic biliary strictures without hepatic artery thrombosis after liver transplantation. T2 - An analysis of 1,113 liver transplantations at a single center. AU - Nakamura, Noboru. AU - Nishida, Seigo. AU - Neff, Guy R.. AU - Vaidya, Anil. AU - Levi, David M.. AU - Kato, Tomoaki. AU - Ruiz, Phillip. AU - Tzakis, Andreas G.. AU - Madariaga, Juan R.. PY - 2005/2/27. Y1 - 2005/2/27. N2 - Background. Intrahepatic biliary strictures (IHBS) without hepatic artery thrombosis (HAT) is a serious complication and known to increase the risk of graft failure after liver transplantation. This manuscript describes the incidence, risk factors, clinical pictures, management, and outcomes. Methods. Between 1994 and 2002, 1,113 liver transplantations were performed in 974 adult patients. Data was retrospectively analyzed in terms of incidence, risk factors, clinical pictures (type of strictures), management (radiologic, surgical management), and outcomes. Results. Sixteen (1.4%) grafts had ...
HEPATIC ARTERY STENOSIS IN ORTHOTOPIC LIVER TRANSPLANTATION (LTX): SINGLE CENTER EXPERIENCE IN A SERIES OF 527 PATIENTS. . Hepatic artery complications after liver transplantation are uncommon- improved techniques.However, they represent an important cause of morbidity and mortality and are a m...
TY - JOUR. T1 - A predictive model for acute allograft rejection of liver transplantation. AU - Liu, Chien-Liang. AU - Soong, Ruey Shyang. AU - Lee, Wei Chen. AU - Chen, De Hsuan. AU - Hsu, Shang Hwa. PY - 2018/3/15. Y1 - 2018/3/15. N2 - Orthotopic liver transplantation (OLT) has become an increasingly used treatment for end-stage liver disease. However, acute allograft rejection is still a problem in postoperative care of liver transplantation with immunosuppressive therapy and it can lead to allograft damage and harm the survival of liver transplantation patient. This work proposes to use data-driven approach to build a predictive model for acute rejection. We consider not only prediction accuracy, but also interpretability of the prediction outcome in building the predictive model, so that the medical staffs can identify how the prediction is induced from data. The experiments use the real data provided by liver transplantation intensive care unit (ICU) of Chang Gung Memorial Hospital, ...
Purpose: Left-lobe grafts are underused for adult liver transplantation in the United States. Better strategy is needed to expand the use of left lobe in both deceased split (DST) and living donor transplantation (LDT).. *Methods: Retrospective review of 80 LDT and 68 DST performed between 2004 and 2017 in the single institution. The study period was divided to before and after 2010, when a novel triple hepatic vein outflow technique was introduced and inflow modulation was converted from portocaval shunt to splenectomy.. *Results: Left-lobe utilization in LDT was well with 40% during the overall study period, and that of DST was increased from 0% to 27% in the later period. Selecting smaller recipients for left-lobe DST enabled to have a decent graft-to-recipient weight ratio (GRWR). Compared to DST, LDT using left-lobe was performed with a significantly lower median GRWR (0.79 vs. 1.24), and higher portal flow (150 vs. 106 mL/100gLW), with more frequent inflow modulation (56% vs. 7%). In the ...
The Liver Care Center provides liver donor options, liver transplant techniques and information on the liver transplant process for treatment of end-stage liver disease in children. Learn more about liver transplantation and the pediatric liver transplant program at St. Louis Childrens Hospital.
A recent study by doctors at the University of Washington explained that patients who are significantly underweight or very severely obese prior to liver transplantation are at increased risk of death following transplantation surgery. These findings, from the largest known observation of liver transplantation at the extremes of BMI, are published in the August issue of Liver Transplantation, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.
Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, although availability of donor organs is a major limitation. The most common technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic position as the original liver. The surgical procedure is complex, requiring careful harvest of the donor organ and meticulous implantation into the recipient. Liver transplantation is highly regulated, and only performed at designated transplant medical centers by highly trained transplant physicians and supporting medical team. The duration of the surgery ranges from 4 to 18 hours depending on outcome.[medical citation needed] Favorable outcomes require careful screening for eligible recipient, as well as a well-calibrated live or cadaveric donor ...
govind ram liver transplant consultant of india support group provides information on liver transplant in india, cost of liver transplant, liver diseases, liver transplant, pre-transplant preparation, peri or post transplant care of liver recipient and liver donor, cadaver organ donation,cadaver liver donation, etc. by the most experienced liver transplant coordinator Anshu Gupta in india.,Complete Medical Guide to Organ donation, Organ Transplant, Multi-Organ Transplant,Gastroenterology,Hepatology,GI Surgery,, Liver Cirrhosis,liver diseases,Liver Operation, Liver Specialist,liver surgery,Liver Transplant India, Liver Transplant in India, Liver Transplant Surgeon, Liver Transplantation,Gastrointestinal Surgery,Support Group, Liver Transplant Consultant of India,Govind Ram, Dr Subash Gupta,Anshu Gupta,Liver Transplant India, Liver Transplant,Gastroenterology,Hepatology,GI Surgery,, Liver Cirrhosis,liver diseases,Liver Operation, Liver Specialist,liver surgery Liver Transplant, liver transplant
Vijay Vohra is the Chairman of Liver Transplant and GI Anaesthesia, at Medanta - The Medicity, Delhi NCR, India, leading a team with experience of nearly 3500 liver transplants. He has been a pioneer in the field of Liver Transplant Anaesthesia in India and has been involved in the training of the next generation of Indian LT anaesthesiologists, as well as Fellows from overseas for the last two decades. With several book chapters and publications in indexed Journals and vast experience in the field, he is also currently editing a book titled Perioperative Anaesthetic Management in Liver Transplantation for Springer publications. Dr Vohra is currently the President of the Liver Transplant Anaesthesia and Critical Care Society of India (LITRACSI ...
Expanded criteria donor grafts for deceased donor liver transplantation under the MELD system: a decision analysis. Liver Transpl. 2004 Dec; 10(12):1468-75 ...
Keywords: Hepatitis C Liver transplantation Sustained virological response Recurrent hepatitis C Transplantation results Intro Chronic hepatitis C disease (HCV) illness leading to decompensated liver cirrhosis or hepatocellular carcinoma is the main cause of orthotopic liver transplantation (OLT) worldwide. It is expected that the number of individuals with HCV illness referred for OLT will continue to increase in the next years in spite of improvements in antiviral therapy (1). Nonetheless if HCV viremia is present during the transplantation process the result is definitely common reinfection of liver allografts happening as early as the reperfusion phase of the surgical procedure with viral replication within hours after OLT (2 3 Recurrent liver disease due to HCV usually evolves after 3 months and is present in up to 70-90% of individuals 1 year after OLT. Furthermore the progression BEZ235 of recurrent disease is faster than in the immunocompetent human population (4 -7). Recurrent liver ...
TY - JOUR. T1 - Auxiliary partial orthotopic liver transplantation from living donors. AU - Ikegami, Toru. AU - Shiotani, Satoko. AU - Ninomiya, Mizuki. AU - Minagawa, Ryosuke. AU - Nishizaki, Takashi. AU - Shimada, Mitsuo. AU - Sugimachi, Keizo. PY - 2002. Y1 - 2002. N2 - Auxiliary liver transplantation was originally started in Western countries in the form of heterotopic auxiliary liver transplantation for end-stage liver disease. It thereafter developed into the form of auxiliary partial orthotopic liver transplantation for acute liver failure. In Japan, where living-donor liver transplantation is the main mode of liver transplantation, auxiliary partial orthotopic liver transplantation was initially used for patients with metabolic liver diseases and has since developed into an effective solution for small-for-size living donor grafts. Although there has been a reported case of successful auxiliary partial orthotopic liver transplantation from a living donor for the treatment of acute liver ...
Aim: Living related liver transplantation (LRLT) has been developed in response to the paediatric organ donor shortage. Though it has been succeeded in many centers worldwide, the safety of the donor is still a major concern, especially in donors with anatomy variation. We succeeded in performing the first two cases of living related liver transplantation with complicated anatomy of blood vessels as a way to overcome cadaveric organ shortage in Beijing. Methods: Two patients, with congenital liver fibrosis and congenital biliary atresia were performed with living donor liver transplantation in our hospital and then followed up from November 12 to December 13, 2001. The two living donors, mother and father, were healthy aged 34 and 35 years. One right lobe (segment V, VI, VII, VIII) and one left lateral lobe (segment II and III) were used. The grafts weighed 394 g and 300 g. The ratio of graff weight to the standard liver volume (SLV) of donors was 68% and 27%. The graft weight to recipient body ...
ALVES, Rogério Camargo Pinheiro et al. Predictive factors of early graft loss in living donor liver transplantation. Arq. Gastroenterol. [online]. 2012, vol.49, n.2, pp.157-161. ISSN 0004-2803. CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. ...
Preservation of Arterial Vascularization After Hepatic Artery Pseudoaneurysm Following Orthotopic Liver Transplantation: Long-Term Results - Get your full text copy in PDF #890473
TY - JOUR. T1 - Biliary complications in adult living donor liver transplantation with duct-to-duct hepaticocholedochostomy or Roux-en-Y hepaticojejunostomy biliary reconstruction. AU - Kawachi, Shigeyuki. AU - Shimazu, Motohide. AU - Wakabayashi, Go. AU - Hoshino, Ken. AU - Tanabe, Minoru. AU - Yoshida, Masashi. AU - Morikawa, Yasuhide. AU - Kitajima, Masaki. PY - 2002. Y1 - 2002. N2 - Background. The aim of this study was to compare lhe incidence of biliary complications after adult living donor liver transplantation (ALDLT) with Roux-en-Y hepaticojejunostomy (R-Y HJ) or duct-to-duct hepaticocholedochostomy (D-D HC). Methods. Biliary complications were reviewed in 20 consecutive ALDLT recipients surviving more than 1 month, including 10 patients who underwent R-Y HJ and 10 patients who underwent D-D HC reconstructions. Results. Ten biliary complications were seen in 8 patients (40%) from the study group. Specifically, 1 case of biliary leakage and 1 case of biliary hemorrhage were observed in ...
TY - JOUR. T1 - Living Donor Liver Transplantation for Acute Liver Failure. T2 - A 10-Year Experience in a Single Center. AU - Ikegami, Toru. AU - Taketomi, Akinobu. AU - Soejima, Yuji. AU - Yoshizumi, Tomoharu. AU - Sanefuji, Kensaku. AU - Kayashima, Hiroto. AU - Shimada, Mitsuo. AU - Maehara, Yoshihiko. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2008/3. Y1 - 2008/3. N2 - Background: Living donor liver transplantation has become an accepted treatment for various terminal liver diseases. Study Design: Forty-two living donor liver transplantations performed for acute liver failure during a 10-year period at Kyushu University Hospital were reviewed. Results: Causes of liver failure included hepatitis B (n = 12), hepatitis C (n = 1), autoimmune hepatitis (n = 2), Wilsons disease (n = 3), and unknown causes (n = 24). The graft types were: left lobe (n = 33), right lobe (n = 8), and lateral segment (n = 1). The mean graft volume to standard liver volume ratios were 42.2 ...
Looking for online definition of orthotopic liver transplantation in the Medical Dictionary? orthotopic liver transplantation explanation free. What is orthotopic liver transplantation? Meaning of orthotopic liver transplantation medical term. What does orthotopic liver transplantation mean?
BOTHA, J et al. Living donor liver transplantation in South Africa: the donor experience. S. Afr. j. surg. [online]. 2019, vol.57, n.3, pp.11-16. ISSN 2078-5151. BACKGROUND: Living donor liver transplantation (LDLT) plays a crucial role in liver transplant programmes, particularly in regions with a scarcity of deceased donor organs and especially for paediatric recipients. LDLT is a complex and demanding procedure which places a healthy living donor in harms way. Donor safety is therefore the overriding concern. This study aimed to report our standardised approach to the evaluation, technical aspects and outcomes of LDLT donor hepatectomy at Wits Donald Gordon Medical CentreMETHODS: The study population consisted of all patients undergoing LDLT donor hepatectomy since the inception of the programme in March 2013 until 2018. Sixty five living donor hepatectomies were performed. Primary outcome measures included donor demographics, operative ...
Objectives: Portal vein (PV) reconstruction is a crucial factor for successful living donor liver transplantation (LDLT). Portal vein thrombosis (PVT) remains a critical problem in LDLT because of technical demands and sufficient venous graft harvesting. This study aimed to describe in detail of PV reconstruction and outcomes of patients with PVT.. Methods: We performed adult-to-adult LDLT for 123 patients between March 2002 and December 2016. Thirteen patients (10.6%) had PVT at the time of LDLT, which were classified as grade I in 2 patients, grade II in 4 patients, grade III in 6 patients and grade IV in 1 patient, according to Yerdel's classification. We retrospectively analyzed the surgical technique and postoperative complications of PV reconstruction for patients with PVT, and compared to patients without PVT.. Results: Surgical treatments for 13 patients with PVT were as follows: thrombectomy alone in 2 patients, replaced interpositional venous grafts in 8 patients: 3 using internal ...
TY - JOUR. T1 - Complications of arterial reconstruction in living donor liver transplantation. T2 - A single-center experience. AU - Matsuda, Hiroaki. AU - Yagi, Takahito. AU - Sadamori, Hiroshi. AU - Matsukawa, Hiroyoshi. AU - Shinoura, Susumu. AU - Murata, Hiroshi. AU - Umeda, Yuzo. AU - Tanaka, Noriaki. PY - 2006/3. Y1 - 2006/3. N2 - Purpose. Microsurgical reconstruction of the fine hepatic arteries (HA) reduces the chance of complications in living donor liver transplantation (LDLT). We reviewed HA reconstructions and analyzed their complications and treatment in a single center. Methods. Between August 1996 and September 2004, we performed LDLT on 71 adults and 19 children. Patients received a lateral segment graft (n = 16), a left lobe graft (n = 11), an extended left lobe graft (n = 12), or a right lobe graft (n = 51). Results. Hepatic artery reconstruction was performed by end-to-end anastomosis under an operating microscope in all except five adults who received right lobe grafts with ...
TY - JOUR. T1 - Liver regeneration in donors and adult recipients after living donor liver transplantation. AU - Haga, Junko. AU - Shimazu, Motohide. AU - Wakabayashi, Go. AU - Tanabe, Minoru. AU - Kawachi, Shigeyuki. AU - Fuchimoto, Yasushi. AU - Hoshino, Ken. AU - Morikawa, Yasuhide. AU - Kitajima, Masaki. AU - Kitagawa, Yuko. PY - 2008/12/1. Y1 - 2008/12/1. N2 - In living donor liver transplantation, the safety of the donor operation is the highest priority. The introduction of the right lobe graft was late because of concerns about donor safety. We investigated donor liver regeneration by the types of resected segments as well as recipients to assess that appropriate regeneration was occurring. Eighty-seven donors were classified into 3 groups: left lateral section donors, left lobe donors, and right lobe donors. Forty-seven adult recipients were classified as either left or right lobe grafted recipients. Volumetry was retrospectively performed at 1 week, 1, 2, 3, and 6 months, and 1 year ...
TY - JOUR. T1 - Survival of Clostridium perfringens sepsis in a liver transplant recipient. AU - Diaz, Geraldine C.. AU - Boyer, Thomas. AU - Renz, John F.. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Clostridium perfringens sepsis following orthotopic liver transplantation (OLT) is a rare but reported complication that historically results in mortality or emergent retransplantation (ReTx).1-7 Complications from C. perfringens emphysematous gastritis have contributed to the death of a healthy live liver donor as well.8 Herein, we describe the first documented survivor of C. perfringens sepsis following OLT managed without laparotomy or emergent ReTx.. AB - Clostridium perfringens sepsis following orthotopic liver transplantation (OLT) is a rare but reported complication that historically results in mortality or emergent retransplantation (ReTx).1-7 Complications from C. perfringens emphysematous gastritis have contributed to the death of a healthy live liver donor as well.8 Herein, we describe the ...
The A2ALL consortium was chartered in 2002 and has collected data on a large cohort of donor and recipient candidates for LDLT spanning over a decade of activit...
Few reports of liver transplantation exist in patients with congenital absence of the portal vein and pulmonary hypertension. Living donor liver transplantation is usually performed before exacerbation of pulmonary hypertension. A 7-year-old girl (height: 131.5 cm; weight: 27.4 kg) with congenital absence of the portal vein was diagnosed with pulmonary hypertension (mean pulmonary artery pressure 35 mm Hg), and liver transplantation was planned before exacerbation of pulmonary hypertension. We successfully managed her hemodynamic parameters using low-dose dopamine and noradrenaline under monitoring of arterial blood pressure, central venous pressure, cardiac output, and stroke volume variation. Anesthesia was maintained using air-oxygen-sevoflurane and remifentanil 0.1 to 0.6 μg∙kg-1∙min-1. It is necessary to understand the potential perioperative complications in such cases and to adopt a multidisciplinary team approach in terms of the timing of transplantation and readiness to deal with ...
TY - JOUR. T1 - Heterotopic liver transplantation for fulminant Wilsons disease. AU - Stampfl, David A.. AU - Muñoz, Santiago J.. AU - Moritz, Michael J.. AU - Rubin, Raphael. AU - Armenti, Vincent T.. AU - Jarrell, Bruce E.. AU - Maddrey, Willis C.. PY - 1990. Y1 - 1990. N2 - Wilsons disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilsons disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated with heterotopic liver transplantation. However, use of heterotopic liver transplantation for fulminant hepatocellular failure has not been successful. This case study involves a patient in whom a heterotopic liver transplant was successfully used for treatment of Wilsons disease presenting with fulminant hepatocellular failure.. AB - Wilsons disease may present with severe acute hepatocellular failure. The ...
TY - JOUR. T1 - Hepatitis C testing. T2 - Comparison of Orthos EIA and RIBA II tests in 1,182 patients undergoing primary liver transplantation. AU - Rochlani, M.. AU - Lewis, J. H.. AU - Ramsey, G. E.. AU - Bontempo, F. A.. AU - Shah, G.. AU - Bowman, R. A.. AU - Van Thiel, D. H.. AU - Starzl, T. E.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1992. Y1 - 1992. N2 - Plasma samples from 1,182 patients undergoing primary liver transplantation were tested for anti-hepatitis C (HCV) virus by two methods: Ortho HCV ELISA Test System (EIA) and Chiron RIBA HCV Test System (RIBA II). The EIA results, 0 or +, were recorded first, followed by RIBA results, N = negative, P = positive, or I = indeterminate. Concordant results-ON, + P, + I-were found in 1,076 (91%), and discordant results were found in 106 (9%). The EIA optical density did not relate to concordant or discordant results. Band patterns were described by stating the band position (1, 2, 3, or 4) and inserting a ...
Clinical analysis of neurological complications following liver transplantation, Congran Li, Hailong Jin, Qing Yuan, Ming Cai, Zhouli Li, Guosheng Du, Bingyi Shi
TY - JOUR. T1 - Successful liver transplantation (OLT) in a child with fulminant hepatic failure due to primary ebv infection. T2 - 154. AU - Feranchak, A. P.. AU - Karrer, F. M.. AU - Narkewicz, M. R.. AU - Tyson, R. W.. AU - Sokol, R. J.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1997/10. Y1 - 1997/10. UR - UR - U2 - 10.1097/00005176-199710000-00171. DO - 10.1097/00005176-199710000-00171. M3 - Article. AN - SCOPUS:85026166755. VL - 25. SP - 480. JO - Journal of Pediatric Gastroenterology and Nutrition. JF - Journal of Pediatric Gastroenterology and Nutrition. SN - 0277-2116. IS - 4. ER - ...
Living donor liver transplantation offers an alternative when time matters. Cleveland Clinics Living liver donor program is the only one in Ohio performing both adult and pediatric living-donor liver transplants.
The Department of Surgery of the University of Hong Kong will host Adult Right Living Donor Liver Transplantation - 20 Years On on Thursday, Aug. 18, at the Renaissance Hong Kong Harbour View Hotel in Wan Chai ...
Post-transplant lymphoproliferative disorder is a life-threatening complication of solid organ transplantation. In pediatric recipients, PTLD has been reported in 6.4-19.5 of lung, heart and heart-lung transplants, 4-15 of liver transplants and 1.2-10.1 of kidney transplants. Although most lymphomas typically occur in lymph nodes, extranodal involvement is also common. The aim of our study was to determine the site and symptoms of PTLD in children who underwent liver transplantation during 2009-2012 in Liver Transplantation Center of Nemazee Hospital. Material and methods: This study is a cohort study on existing data of children who received liver transplant between Juanury 2009 and December 2012 at Liver Transplant Center of Nemazee Hospital in Shiraz. During the study period, the PTLD occurrence was assessed in follow up visits, if the diagnosis of PTLD was confirmed the affected patient was entered the study and additional information was obtained. The diagnosis of PTLD was considered in ...
TY - JOUR. T1 - Four cases of human herpesvirus 6 variant B infection after pediatric liver transplantation. AU - Yoshikawa, Tetsushi. AU - Ihira, Masaru. AU - Furukawa, Hiroshi. AU - Suga, Sadao. AU - Asonuma, Katsuhiro. AU - Tanaka, Koichi. AU - Asano, Yoshizo. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1998/5/15. Y1 - 1998/5/15. N2 - Background. Little is known about human herpesvirus (HHV)-6 infection after liver transplantation. We present our experiences with four cases of HHV-6 infection after liver transplantation from living related donors. Methods. Peripheral blood was collected from four donor and recipient pairs at the time of transplantation and biweekly from the recipients after transplantation. We attempted to isolate HHV-6 and measure antibody titers to HHV-6 and HHV-7. Results. HHV-6 was isolated from four recipients approximately 2 weeks after transplantation. A significant rise in HHV-6 antibody titers was observed in four recipients at some point ...
Edwin C. and Anne K. Weiskopf Professor of Surgical Oncology (212) 305-5101 Tomoaki Kato, M.D., is a noted pioneer in multiple-organ transplantation, pediatric and adult liver transplantation. Dr. Kato is Surgical Director of Adult and Pediatric Liver and Intestinal Transplantation at NewYork-Presbyterian Hospital/Columbia University Medical Center and is a professor of surgery at Columbia University College of Physicians and Surgeons. Dr. Kato is known for unique and innovative surgeries for adults and children, including a six-organ transplant; a procedure called APOLT (auxiliary partial orthotopic liver transplantation) that resuscitates a failing liver by attaching a partial donor liver, making immunosuppressant drugs unnecessary and the first successful human partial bladder transplantation involving the transplant of two kidneys together with ureters connected to a patch of the donor bladder. In a highly publicized case, he led the first reported removal and re-implantation, or auto
Hwang, S., Lee, S.-G., Moon, D.-B., Ahn, C.-S., Kim, K.-H., Lee, Y.-J., Ha, T.-Y. and Song, G.-W. (2007), Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma. Liver Transpl, 13: 741-746. doi: 10.1002/lt.21157 ...
Hwang, S., Lee, S.-G., Lee, Y.-J., Sung, K.-B., Park, K.-M., Kim, K.-H., Ahn, C.-S., Moon, D.-B., Hwang, G.-S., Kim, K.-M., Ha, T.-Y., Kim, D.-S., Jung, J.-P. and Song, G.-W. (2006), Lessons learned from 1,000 living donor liver transplantations in a single center: How to make living donations safe. Liver Transpl, 12: 920-927. doi: 10.1002/lt.20734 ...
Health, ...Living donor liver transplantation (LDLT) has been used to alleviate t...A research article to be published on August 28 2009 in the World ...The results demonstrated that the Chengdu formula was reliable by its ...With national multicenter data in the future the Chengdu formula for ...,,Evaluation,of,standard,liver,volume,formula,for,Chinese,adults,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
TY - JOUR. T1 - Improved results of liver transplantation in patients with portal vein thrombosis. AU - Seu, Philip. AU - Shackleton, Christopher R.. AU - Shaked, Abraham. AU - Imagawa, David K.. AU - Olthoff, Kim M.. AU - Rudich, Steven R.. AU - Kinkhabwala, Milan. AU - Busuttil, Ronald W.. PY - 1996/8. Y1 - 1996/8. N2 - Objective: To analyze the impact of preexisting portal vein thrombosis (PVT) on the operative management and outcome of liver transplantation. Design: Retrospective review of 1423 patients who received transplants over 11 years. Setting: Tertiary referral center. Patients or Other Participants: Seventy patients who underwent liver transplantation who had preexisting PVT. Interventions: Portal vein thromboendovenectomy, vein grafting, or use of portal collateral veins for inflow during liver transplantation. Main Outcome Measures: Postoperative PVT, intraoperative transfusion, retransplantation rate, 30-day and 1-year actuarial survival tales. Results: Operative management ...
In living donor liver transplantation, the recipient liver undergoes more rapid regeneration than the remnant liver in the donor. In this study we investigated the factors which may be responsible for the difference in the regenerative response between the donor and the recipient. <br>Long Evans rats were subjected to either partial hepatectomy (PH) or sham operation (SH) and were treated with liver cytosol (C) and cyclosporine (Cy). The rats were sacrificed at 24, 48, 72 and 96 hours and 1 and 2 weeks postoperatively. The livers were removed to determine the liver weight/body weight (LW / BW ) ratio and the mitotic index. <br>The mitotic index, serum aspartate transferase (AST) and serum alanine transferase (ALT), although unchanged in the SH groups, were increased in the rats treated with PH + C + Cy, and were greater than after PH only. However LW / BW ratios increased after PH but had returned to preoperative levels by 2 weeks. The changes in LW / BW ratio were not modified by the
A 33-year-old Japanese man who had suffered from liver cirrhosis due to hepatitis C virus (HCV) underwent living related liver transplantation (LRLT). The allograft was given by his brother, who was healthy with no history of hepatitis or hepatic virus infection. After LRLT, the patients hepatitis C recurred. Liver biopsy revealed chronic viral hepatitis and no allograft rejection such as shown by portal lymphocytic infiltration or mild bridging fibrosis. Interferon and ribavirin were administered, and sustained viral response (SVR) was obtained. Although serum hepatitis B virus (HBV)-DNA/HCV-RNA polymerase chain reaction found no presence of hepatic virus, the serum examination demonstrated liver dysfunction seven months after SVR. Liver biopsies histopathologically showed portal fibrosis invading to the sinusoids, cholestasis, mild hyperplasia of the cholangioles, and no features of allograft rejection. Fibrosing cholestatic hepatitis (FCH) was diagnosed. The FCH was resistant to treatment ...
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology that is progressive in most symptomatic patients, advancing toward cirrhosis and liver failure. Liver transplantation is the only therapeutic option for patients with end stage liver disease resulting from this disorder. The results of transplantation for PSC are excellent with one-year survival rates of 90-97% and five-year survival rates of 80-85%, but are closely related to pre-transplant Child-Pugh stage. Recurrence of PSC after liver transplantation is common, occurring in up to 20% of patients, but it appears to have little effect on patient survival, as survival of patients with recurrent PSC is similar to that of those without evidence of recurrence. Cholangiocarcinoma is a catastrophic complication of PSC and as yet no reliable screening method exists. The results of liver transplantation for patients with clinically apparent cholangiocarcinoma are extremely poor, however in patients in whom a
TY - JOUR. T1 - Preoperative hepatic artery chemoembolization followed by orthotopic liver transplantation for hepatocellular carcinoma. AU - Harnois, D. M.. AU - Steers, J.. AU - Andrews, J. C.. AU - Rubin, J. C.. AU - Pitot, H. C.. AU - Burgart, L.. AU - Wiesner, R. H.. AU - Gores, G. J.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1999. Y1 - 1999. N2 - In our experience, the primary obstacle precluding the widespread use of orthotopic liver transplantation (OLT) for definitive therapy of hepatocellular carcinoma (HCC), even for early-stage disease, is preventing tumor recurrence. Chemoembolization is an attractive strategy to minimize tumor progression before OLT because of its shown antitumor effect, ability to be repeated, and minimal systemic toxicity. Thus, this pilot study was undertaken to determine the tolerability and treatment outcomes of pretransplantation chemoembolization of HCC followed by OLT. Between 1992 and 1997, 27 patients with HCC who had ...
Living donor liver transplants - Department of Surgery - Living Donor Liver Transplant. We provides LiverActive Liver Detox formula contains several natural ingredients to help maintain a healthy liver. Listen to your liver and dont ignore the warning signs.
One of the most feared complications in liver transplantation is hepatic arterial thrombosis (HAT). The incidence of HAT in liver transplantation varies from 1.2% and 8%. One of the risk factors for this complication is anatomical complexity of hepatic arterial system. The focus of this short communication is to show our approach in dealing with aberrant left hepatic artery in settings of liver transplantation. This is a single center experience. Between January 2016 and June 2019, we procured and transplanted 357 adult liver allografts. Of these, there were 34 (9.5%) livers with aberrant left hepatic artery. All of them have been reconstructed on bench table. There was no incidence of HAT in the entire cohort with ALHA. The one-year graft survival for this patient cohort was 93.1%. Our surgical approach resulted in a low incidence of HAT of 1% with excellent graft survival.
TY - JOUR. T1 - Hepatopulmonary syndrome and portopulmonary hypertension. T2 - Implications for liver transplantation. AU - Krowka, Michael J.. PY - 2005/12/1. Y1 - 2005/12/1. N2 - HPS and POPH are uncommon but potentially serious pulmonary consequences of advanced liver disease. The major considerations for liver transplantation posed by these disorders are summarized in Table 4. Remarkably, HPS may completely resolve after OLT; the post-OLT outcome of POPH is less predictable. Both syndromes, under certain conditions, may represent high-risk situations for OLT. The unique opportunity to reverse serious dysfunction in one organ (the lungs) by the successful transplantation of another organ (the liver) is worthy of further clinical investigations.. AB - HPS and POPH are uncommon but potentially serious pulmonary consequences of advanced liver disease. The major considerations for liver transplantation posed by these disorders are summarized in Table 4. Remarkably, HPS may completely resolve ...
PURPOSE: LRLT in children is a method to provide organs for transplantation. We report 2 cases of LLLS for pediatric LRLT. METHOD: Donor position: lithotomy with surgeon in French position. Trocars: three 12 mm, placed 2 cm upper the supra-umbilical mid-line and sub-costal bi-lateral on the nipple lines; one 5 mm in epigastrium. Special instrumentation: harmonic scissor, ligasure®, Hem-O-Lock clips, and Endo Catch-II® bag. Main steps: division of round, falciform, left triangular ligaments and of lesser omentum; inspection of anatomy; hepatic hilum dissection with exposure of the left hepatic artery; dissection of the right side of the falciform ligament with exposure of the left branch of the portal vein; dissection of the Arantius ligament and exposure of the left hepatic vein; parenchymal dissection with hilar plate and left biliary duct(s) section; Pfannestiel incision; placement of the graft (S2-3) into an Endo Catch-II® bag; vessels transection with endoTA; graft extraction. RESULTS: ...
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In acute attacks of acute intermittent porphyria, the mainstay of treatment is glucose and heme arginate administration. We present the case of a 58-year-old patient with acute liver failure requiring urgent liver transplantation after erroneous 6-fold overdose of heme arginate during an acute attack. As recommended in the product information, albumin and charcoal were administered and hemodiafiltration was started, which could not prevent acute liver failure, requiring super-urgent liver transplantation after 6 days. The explanted liver showed no preexisting liver cirrhosis, but signs of subacute liver injury and starting regeneration. The patient recovered within a short time. A literature review revealed four poorly documented cases of potential hepatic and/or renal toxicity of hematin or heme arginate. This is the first published case report of acute liver failure requiring super-urgent liver transplantation after accidental heme arginate overdose. The literature and recommendations in case ...
Selecting a marginal donor in liver transplantation (LT) remains controversial but is necessary because of the small number of available donors. A 46-year-old Japanese woman was a candidate to donate her liver to her brother, who had decompensated liver cirrhosis of unknown origin. Eight years before the donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C virus (HCV) infection (serotype 2). She had received anti-viral therapy with interferon α-2b three times weekly for 24 weeks and had a sustained viral response (SVR). A biopsy of her liver before the donation showed normal findings without any active hepatitis, and her serum was negative for HCV-RNA. Only 67 patients have undergone LT from a cadaveric donor in Japan. The family in this case decided to have living donor LT. A careful selection for the liver graft donation was made; however, since she was the only candidate, we approved her as a living donor. She was discharged nine days after the liver donation. Her liver
TY - JOUR. T1 - Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation. AU - Gawrieh, Samer. AU - Papouchado, Bettina G.. AU - Burgart, Lawrence J.. AU - Kobayashi, Shogo. AU - Charlton, Michael R.. AU - Gores, Gregory J.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - Only a subset of hepatitis C virus (HCV)-infected patients develop progressive hepatic fibrosis after liver transplantation (LT). Hepatic stellate cell (HSC) activation is a pivotal step in hepatic fibrosis and precedes clinically apparent fibrosis. We determined whether early HSC activation, measured in 4-month protocol post-LT biopsies, is predictive of subsequent development of more histologically severe recurrence of HCV. Early (4 month) post-LT HSC activation, as measured by α-smooth muscle actin (α-SMA) staining, was determined in liver biopsies from recipients with severe (fibrosis score ≥ 2, n = 13) and with mild (fibrosis score of 0, n = 13) recurrence of HCV at one-year ...
We prospectively evaluated 84 consecutive adult patients with chronic liver disease before and after liver transplantation to define the type and frequency of post-transplant neurologic complications, and to assess possible pretransplant and operative variables associated with in-hospital CNS complications. There were 25 patients (30%) who presented 23 neurologic complications of the central and six of the peripheral nervous system. Seventy-five percent of the complications occurred in the first month post-transplant. The most frequent CNS complications included anoxic (six patients) and septic (five) encephalopathy, as well as brain hemorrhage (five). Patients who presented CNS complications had a higher mortality rate than those who did not (55% versus 17%, p = 0.002). Multiple logistic regression analysis showed abnormal pretransplant neurologic examination suggestive of chronic hepatic encephalopathy (p = 0.007) and noncholestatic liver disease (p = 0.012) to be independently associated with ...
We are among the nation’s top living donor liver transplant centers, offering safe and effective surgery to more patients at an earlier stage of liver disease.
... or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another ... Living donor liver transplantation for pediatric recipients involves removal of approximately 20% of the liver (Couinaud ... Before transplantation, liver-support therapy might be indicated (bridging-to-transplantation). Artificial liver support like ... A major advance in pediatric liver transplantation was the development of reduced size liver transplantation, in which a ...
"Artificial liver support system in acute liver failure patients waiting liver transplantation". Hepato-gastroenterology. 56 (90 ... 2005). "Outcome from molecular adsorbent recycling system (MARS) liver dialysis following drug-induced liver failure". Liver ... and need for liver transplantation in acute liver failure patients". Transpl Int. 21 (9): 857-866. doi:10.1111/j.1432-2277.2008 ... bioartificial liver device). This system is in trial to help people with acute liver failure (ALF) or acute-on-chronic liver ...
"A survey of liver transplantation from living adult donors in the United States". The New England Journal of Medicine. 348 (9 ... severe cases resulting in liver damage can be fatal without immediate treatment or liver transplantation. In the majority of ... of liver disease, and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The ... The advent of transplantation has changed survival from as low as 15% in the pretransplant era to more than 60% today. Liver ...
Liver Transplantation. 12 (6): 989-92. doi:10.1002/lt.20778. PMID 16721764. S2CID 28255622. Born D, Barron ML (May-June 2005 ... Black cohosh has been implicated in a case of liver failure. Few studies are available on the safety of herbs for pregnant ... lower ongoing pregnancy/live birth rate during 12 months of fertility treatment". Human Reproduction. 24 (7): 1626-31. doi: ... lower ongoing pregnancy and live birth rate during fertility treatment. Examples of herbal treatments with likely cause-effect ...
Liver Transplantation. 10 (8): 1055-1059. doi:10.1002/lt.20154. PMID 15390333. Azeredo da Silveira S, Kikuchi S, Fossati-Jimack ... IgG subclasses to fix complement may explain why some anti-donor antibody responses do harm a graft after organ transplantation ...
2004). "Protective anti-donor IgM production after crossmatch positive liver-kidney transplantation". Liver Transplantation. 10 ... The development of anti-donor IgM after organ transplantation is not associated with graft rejection but it may have a ...
Of late there has been renewed interest in liver transplantation from deceased donors along with add on therapy. Prognosis ... Liver Transplantation. 10 (10 Suppl 2): S65-568. doi:10.1002/lt.20266. PMID 15382214. (CS1 Spanish-language sources (es), CS1 ... More often, liver resection is not a viable option because many patients are of advanced age, have multiple co-pathologies and ... Heimbach JK, Haddock MG, Alberts SR, Nyberg SL, Ishitani MB, Rosen CB, Gores GJ (2004). "Transplantation for hilar ...
"Seroconversion After Coronavirus Disease 2019 Vaccination in Patients Awaiting Liver Transplantation: Fact or Fancy?". Liver ... Many otherwise ill individuals, such as those with cancer or chronic liver disease, still exhibit similar rates of ... Transplantation. 28 (2): 180-187. doi:10.1002/lt.26312. ISSN 1527-6473. PMC 8662269. PMID 34564945. S2CID 237943677. Ollila, ...
It is anticipated that this technology will enable the production of livers in the future for transplantation and theoretically ... Bioartificial liver device, "Temporary Liver", Extracorporeal Liver Assist Device (ELAD): The human hepatocyte cell line (C3A ... A fully capable ELAD would temporarily function as an individual's liver, thus avoiding transplantation and allowing ... July 2009). "Generation and transplantation of an autologous vascularized bioartificial human tissue". Transplantation. 88 (2 ...
"Current role of liver transplantation for the treatment of urea cycle disorders: A review of the worldwide English literature ... Liver Transplantation. 11 (11): 1332-1342. doi:10.1002/lt.20587. PMID 16237708. S2CID 25787334. Maestri, N. E.; Clissold, D.; ... In cases where prenatal diagnosis was requested, a fetal liver biopsy used to be required to confirm if a fetus was affected. ... Liver transplant is considered curative for this disease. Experimental trials of gene therapy using adenoviral vectors resulted ...
Raia was the first doctor to achieve a successful living donor liver transplantation in July 1989. Chakravarty, Dilip K.; Lee, ... Liver Transplantation. ISBN 9788184487701. Retrieved 2020-05-08. Clavien, Pierre-Alain; Breitenstein, Stefan; Belghiti, Jacques ... living people), Living people, Brazilian transplant surgeons, All stub articles, South American medical biography stubs, ... Silvano Raia is a Brazilian surgeon who specializes in liver diseases. He is a professor emeritus at the Faculty of Medicine of ...
CRE infections can set in about 12 days after liver transplantation, and 18% of those patients died a year after ... Liver Transplantation. 18 (4): 468-474. doi:10.1002/lt.23374. PMID 22467548. S2CID 46280258. Warnes, Sarah L.; Highmore, C. J ... Patients had risk factors including diabetes, HIV infection, heart disease, liver disease, chronic kidney disease, one was a ... Infections with carbapenem-resistant Klebsiella pneumoniae were associated with organ/stem cell transplantation, mechanical ...
"Living-related intestinal transplantation: first report of a standardized surgical technique". Transplantation. 64 (11): 1605-7 ... Intestine transplantation (intestinal transplantation, or small bowel transplantation) is the surgical replacement of the small ... Transplant Living Partnering With Your Transplant Team by UNOS Intestinal Transplantation at eMedicine Intestinal Transplant ... The improvement to quality of life following an intestinal transplantation is significant. Of living patients 6 months after ...
"Liver cell transplantation using a mouse model of Wilson's disease", was on the use of liver cell transplantation to treat ... mediated rejection results in allograft loss after liver cell transplantation". Liver Transplantation. 14 (5): 688-694. doi: ... "Liver cell transplantation using a mouse model of Wilson's disease". University of Melbourne Library. University of Melbourne. ... After completing a PhD at the University of Melbourne in the development of liver cell transplantation as an alternative to ...
"Reliability of a new ultrasonic cardiac output monitor in recipients of living donor liver transplantation". Liver ... "Cardiac output derived from arterial pressure waveform analysis in patients undergoing liver transplantation: validity of a ... In the case of heart failure, actual CO may be insufficient to support even simple activities of daily living; nor can it ... Transplantation. 23 (11): 3578-84. doi:10.1093/ndt/gfn275. PMID 18511608. van Loon M, van der Mark W, Beukers N, de Bruin C, ...
Liver Transplantation. 14 (4): 563-570. doi:10.1002/lt.21395. PMID 18383093. S2CID 13072583. Ferrera LA, ed. (2006). Focus on ... abdominal fat amyloid in patients with familial amyloid polyneuropathy during long-term follow-up after liver transplantation ... Transplantation. 23 (1): 47-51. doi:10.1093/ndt/gfm517. PMID 17890752. Blackburn H, Jacobs D (June 2014). "Commentary: Origins ...
Liver Transplantation. 28 (3): 483-492. doi:10.1002/lt.26339. ISSN 1527-6473. PMC 8857023. PMID 34669243. Sankararaman, ... Cystic fibrosis, diarrhea, liver disease, anemia or iron deficiency, Crohn's disease, and coeliac disease make it more ...
"Antifibrinolytics in orthotopic liver transplantation: current status and controversies". Liver Transplantation. 11 (1): 10-8. ... In liver transplantation, initial reports of benefit were overshadowed by concerns about toxicity. In a meta-analysis performed ... such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown ...
J.-L. Touraine; R.P. Gale; V. Kochupillai (6 December 2012). Fetal liver transplantation. Springer Science & Business Media. p ... J.-L. Touraine; R.P. Gale; V. Kochupillai (6 December 2012). Fetal liver transplantation. Springer Science & Business Media. pp ... 272-. ISBN 978-93-5152-415-1. N. K. Mehra (5 July 2011). "Hematopoietic Stem Cell Transplantation : Opportunities and ... published in Transplantation Proceedings in 2007. He has delivered a number of keynote addresses or invited lectures including ...
Transplantation of the Liver. Elsevier. pp. 23-39. ISBN 978-1-4557-5383-3. "Cantlie's line , Radiology Reference Article". ... The lobes of the liver are further divided into eight liver segments in the Couinaud system. These are also known as hepatic ... is situated upon the posterosuperior surface of the liver on the right lobe of the liver, opposite the tenth and eleventh ... A line can be imagined running from the left of the vena cava and all the way forward to divide the liver and gallbladder into ...
"Liver transplantation for tyrosinemia. A review of 10 cases from the University of Pittsburgh". Digestive Diseases and Sciences ... Symptoms of untreated tyrosinemia include liver and kidney disturbances. Without treatment, tyrosinemia leads to liver failure ... and live normal lives. All tyrosinemias result from dysfunction of various genes in the phenylalanine and tyrosine catabolic ... Liver transplant is indicated for patients with tyrosinemia type I who do not respond to nitisinone, as well as those with ...
Liver transplantation can be curative. Gilbert's syndrome, a genetic disorder of bilirubin metabolism found in a small percent ... Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. ... Progression of the disease can lead to liver inflammation from the excess fat in the liver. Scarring in the liver often occurs ... Fibrinolysis generally proceeds faster with acute liver failure and advanced stage liver disease, unlike chronic liver disease ...
"MoH to start liver transplantation". The Himalayan Times. 2 December 2016. Archived from the original on 12 August 2019. ... Liver transplant service was started for the first time in the country. The government made surgery of gout heart disease and ... The new law allowed the receiving of eight organs - kidneys, lungs, heart, liver, pancreas, small intestine, corneas and skin ... Living people, 1976 births, Nepali Congress politicians from Bagmati Province, Government ministers of Nepal, People from ...
Mohamed Rela, Liver transplantation surgeon who currently serves as its chairman and Director. It is a 450-bedded facility with ... Institute of Liver Disease & Transplantation". ResearchGate. Retrieved 2020-01-07. admin. "DR. RELA INSTITUTE & MEDICAL CENTRE ... Rela Hospital has 55 medical departments and specialties to name a few Advanced Paediatric, Liver Disease and Transplantation, ... "Pune: Chennai-based liver transplant institute ties up with Ruby Hall Clinic". The Indian Express. 2019-10-07. Retrieved 2020- ...
Görlinger K (August 2006). "[Coagulation management during liver transplantation]". Hamostaseologie (in German). 26 (3 Suppl 1 ... Acquired hyperfibrinolysis is found in liver disease, in patients with severe trauma, during major surgical procedures, and ...
February 2008). "Selection of patients for liver transplantation and allocation of donated livers in the UK". Gut. 57 (2): 252- ... Model for End-Stage Liver Disease MELD-Plus Pediatric End-Stage Liver Disease Milan criteria Child-Pugh score "Liver Transplant ... It is used in the United Kingdom to help determine the need for liver transplantation. It was developed from the MELD score, ... The UKELD score was developed in 2008 to aid in the selection of patients for liver transplantation in the U.K. ...
April 2000). "Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to- ... Bilheimer DW, Goldstein JL, Grundy SM, Starzl TE, Brown MS (December 1984). "Liver transplantation to provide low-density- ... Revell SP, Noble-Jamieson G, Johnston P, Rasmussen A, Jamieson N, Barnes ND (November 1995). "Liver transplantation for ... Very severe cases may be considered for a liver transplant; this provides a liver with normally functional LDL receptors, and ...
It causes diseases in humans only rarely, with single case reports of cholangitis following liver transplantation, bacteremia ... "Ochrobactrum intermedium infection after liver transplantation". Journal of Clinical Microbiology. 37 (1): 241-244. doi:10.1128 ...
... two further participants required liver transplantation. It is suspected that the toxicity of fialuridine was a result of ... In a 1993 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from liver failure alongside ... Tujios S, Fontana RJ (April 2011). "Mechanisms of drug-induced liver injury: from bedside to bench". Nature Reviews. ...
"Passenger Lymphocyte Syndrome and Liver Transplantation". Clinical and Developmental Immunology. 2008: 715769. doi:10.1155/2008 ... In tissue and organ transplantation, the passenger leukocyte theory is the proposition that leucocytes within a transplanted ... v t e (Immunology, Organ transplantation, All stub articles, Immunology stubs). ... Hand transplantation. Springer. pp. 210-1. ISBN 978-88-470-0374-3. Snell, George D. (1957). "The homograft reaction". Annual ...
It often occurs in outbreaks, especially among those living in close quarters. In the United States, it is the cause of about ... such as those with common variable immunodeficiency or with a suppressed immune system after organ transplantation. These ... Bile salts are produced by the liver in response to eating fatty foods, and they help with the absorption of consumed lipids. ...
... and that they may live and give thanks in the sight of the Lord for all the days of their lives. Thus let it be, my Lady. ... This, it has been argued, was a transplantation of the image of witch of Western Europe onto the Greek idea of gelloudes. In ... ISBN 9-789-0041-0406-8 Johnston, Sarah Iles (2013). Restless Dead: Encounters Between the Living and the Dead in Ancient Greece ... or I will let them live for a while and then kill them' … . Although the name Gylou is not found on any surviving amulets, ...
Compiled by H. Zwarenstein ... N. Sapeika ... H.A. Shapiro Experience with human heart transplantation : proceedings of the ... The use of live South African female Xenopus frogs was common in Europe, the USA and Australia from the 1930s and through the ... Barnard, Christiaan; Shapiro, Hillel Abbe (1969). Experience with human heart transplantation: proceedings of the Cape Town ... Barnard, Christiaan; Shapiro, Hillel Abbe (1969). Experience with human heart transplantation: proceedings of the Cape Town ...
He lives in the US where he has a following, including the anti-vaccinationist Jenny McCarthy, who wrote the foreword for ... He continued his studies of small intestine transplantation under a Wellcome Trust travelling fellowship at University of ... He was a surgeon on the liver transplant programme at the Royal Free Hospital in London and became senior lecturer and honorary ... Back in the UK, he worked on the liver transplant programme at the Royal Free Hospital in London. In 1993, Wakefield attracted ...
October 2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". ... May 2018). "Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34+ ... Selected and Unmodified Hematopoietic Stem Cell Transplantation". Biology of Blood and Marrow Transplantation. 24 (5): 1079- ... liver cirrhosis and peripheral vascular disease. CD34 has been shown to interact with CRKL. It also interacts with L-selectin, ...
... liver cancer, lung cancer, gynecologic cancers, prostate and urologic cancers, and stem cell transplantation. Pediatric cancers ...
Rarely, the medication can cause serious liver damage, and this can result in liver transplantation or death. Pemoline is a ... Since being introduced, it has been linked with at least 21 cases of liver failure, of which 13 resulted in liver replacement ... Clinicians were little-aware of liver toxicity with pemoline until the 1990s. Warnings for liver toxicity for pemoline were ... Approximately 1-2% of patients taking the drug show elevated levels of liver transaminase enzymes, a marker for liver toxicity ...
"Toward personalized medicine in renal transplantation". Transplantation Proceedings. 42 (8): 2864-7. doi:10.1016/j.transproceed ... "Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes". Drug Metabolism and ... and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative hematopoietic stem cell transplantation ...
Furthermore, an ouabain block of Na⁺-K⁺ pumps in the cerebellum of a live mouse results in it displaying ataxia and dystonia. ... Transplantation. 23 (9): 2723-9. doi:10.1093/ndt/gfn325. PMID 18556748. Blaustein MP, Hamlyn JM (December 2010). "Signaling ...
At the time, Hoover was the longest-lived former U.S. President, a record that would be broken by Ronald Reagan in 2001, who ... Jean Hamburger performed the first kidney transplantation from a deceased donor, after having pioneered kidney transplants in ... Starting at 2:00 in the afternoon local time, Olympic teams from 94 nations marched into the National Stadium and live ... 8 Americans Lost Lives Aboard C-123", Pittsburgh Press, October 27, 1964, p1 "72,000 Say 'Sayonara' to 1964 Olympic Games in ...
"High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells". Transplantation. 75 ...
Whereas the market for organ transplantation is heavily regulated in the United States, the use of cadaver parts for research, ... "Let the dead teach the living: the rise of body bequeathal in 20th-century America." Academic Medicine 82.10 (2007): 1000-1005 ...
"The Telegraph - John McCafferty Longest Living Heart Transplantation Survival",, retrieved 9 February 2017 ... Fisher, Andrew (6 June 2018). "Andrew Fisher on Magdi Yacoub: The icon at the heart of UK organ transplantation". British ... 2004: International Society for Heart and Lung Transplantation Lifetime Achievement Award, at the 24th annual meeting in San ... "ISHLT: The International Society for Heart & Lung Transplantation - 2004 Recipient". Retrieved 23 November 2019. " ...
Harvesting of living reef organisms, including coral, is increasing around the world. Coral is often overharvested to supply ... The colonies remain there from 8 to 24 months to reach a size for transplantation back to the reef. When the corals are big ... Coral is also farmed by scientists for research, by businesses for the live and ornamental coral trade, and by private reef ... "AQUACULTURE OF CORAL, LIVE ROCKS AND ASSOCIATED PRODUCTS - FISHERIES MANAGEMENT PAPER No. 227" (PDF). Fisheries Management ...
Furthermore, gene therapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. Diet ... liver, spleen, and bone marrow. Inside cells under normal conditions, lysosomes convert, or metabolize, lipids and proteins ... therapy is available mainly to treat Fabry disease and Gaucher disease and people with these types of sphingolipidoses may live ...
"Heart Transplantation". Salem Press. Archived from the original on 25 March 2006. Retrieved 8 February 2007. "Definition of ... Washkansky was able to survive the operation and lived for 18 days before dying of pneumonia. On 2 January 1968, Blaiberg ... The success of Blaiberg's heart transplant furthered the progress made in regard to heart transplantation. Blaiberg was born in ... Scheper-Hughes, Nancy (28 September 1999). "Bodies of Apartheid: the Ethics and Economics of Organ Transplantation in South ...
It is possible for candidiasis to spread to/from the mouth, from sites such as the pharynx, esophagus, lungs, liver, anogenital ... organ transplantation and use of indwelling catheters). Oral candidiasis has been recognized throughout recorded history. The ...
"Mickey Mouse in Living Color Volume 2 DVD Review". DVD Dizzy. Retrieved 19 February 2021. Press release for Walt Disney ... Brain transplantation in fiction, 1990s monster movies, 1995 short films, 1990s science fiction films, 1990s English-language ... The short was released on May 18, 2004 on Walt Disney Treasures: Mickey Mouse in Living Color, Volume Two: 1939-Today. It is ...
Blood and Marrow Transplantation and Cellular Therapy) at Stanford University. She is also the Director of the Stanford ... Living people, University of Turin alumni, Stanford University faculty, Italian pediatricians, Italian women physicians, ... "Use of T-allo10 Cell Infusions Combined With Mismatched Related or Mismatched Unrelated Hematopoietic Stem Cell Transplantation ...
She lived for four months (March 2013 - August 2013) isolated in a planetary module, which simulated what life will be like for ... Organ transplantation Iván González Cancel is a cardiovascular and thoracic surgeon who is credited with the realization of the ... Diego R. Solís is the founder and director of the "Centro de Cirugias de Higado y Pancreas" (Liver and Pancreas Surgery Center ... He is a professor of surgery at the University of Puerto Rico and program director of transplantation of organs of the " ...
"I choose not to keep my story private because there are many women who do not know that they might be living under the shadow ... transplantations from a donor). Two years later, in March 2015, after annual test results indicated possible signs of early ... Her mother allowed them to live together in her home, of which Jolie later said, "I was either going to be reckless on the ... When Jolie was six years old, Bertrand and her live-in partner, filmmaker Bill Day, moved the family to Palisades, New York; ...
... in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation". ... The liver hepatocyte is considered to be the source of the LECT2 circulating in blood. However, its expression in these cells ... mRNA for LECT2 is highly expressed in liver tissue and expressed at far lower levels in a wide range of other tssues. Human ... Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver ...
Transplantation journal. "USC AGSA Dinner Dance and Live Auction Raises $25 000". Asbarez. 2006-02-10. "Globalization and the ... He co-authored a research article in the peer-reviewed journal Transplantation on "Cause of Atrioventricular Block in Patients ... "Cause of atrioventricular block in patients after heart transplantation". ... Living people, 1978 births, Businesspeople from Yerevan, 21st-century American businesspeople, American business writers, ...
Kemp, Rob (1 June 2017). "Robo-Op: how robotic surgery is transforming the lives of prostate cancer sufferers". The Telegraph. ... In 2014, he spoke at Pakistan's Sindh Institute of Urology & Transplantation with proposals to assist Pakistani surgeons with ... Living people, Alumni of the University of London, Academics of King's College London, British urologists, Indian emigrants to ...
As Director of one of the largest centers for transplantation in Europe, he led a program of heart and lung transplant and ... Living people, French surgeons, University of Paris faculty, 1951 births, Recipients of the Legion of Honour). ... In 1983, he trained for 6 months at the University of Stanford to specialize in heart and lung transplantation with Professor N ... and then became director of the cardio-thoracic surgery and transplantation at the Harefield Hospital. He also continued his ...
Probiotics are living bacteria or fungi that confer health benefits. They have 3 mechanisms of therapeutic effect: ... The microbiota of treated patients typically resembles that of the donor after transplantation. In a systematic review of the ... Through these methods, the gut microbiota, the community of 300-500 microorganism species that live in the digestive tract of ... "Fecal Microbiota Transplantation (FMT), Bacteriotherapy". American College of Gastronomy. Retrieved 3 June 2018. Cammarota, G ...
Like the Jews living in Hungary, most of the Jews in Northern Transylvania (about 150,000) were sent to concentration camps ... Hungary will resolve all issues related to the transplantation of optants in a broad and accommodating manner. Romanian ... There were also Hungarians who came to defend Romanian families, putting their lives in danger through this gesture. Thus, at ...
"Celiac disease autoantibodies in severe autoimmune liver disease and the effect of liver transplantation". Liver Int. 28 (4): ... This dynamic can change if the population expands rapidly from a few individuals that lived in isolation as long as other ...
Mitchison discovered the transference of transplantation immunity by sensitised cells, thereby providing evidence relating ... is a graft of living cells and not a humoral agent. He carried out the most exact quantitative analysis of tolerance hitherto ... Living people, British zoologists, British immunologists, Fellows of the Royal Society, People educated at Leighton Park School ... transplantation immunity to hypersensitivity reactions of the 'delayed' type. He devised a method for revealing mixtures of ...
Read about risks, outlook and the process for getting a liver transplant. ... You cannot live without a liver that works. If your liver fails, your doctor may put you on a waiting list for a liver ... During a liver transplantation, the surgeon removes the diseased liver and replaces it with a healthy one. Most transplant ... Getting a New Liver: Facts about Liver Transplants (American Society of Transplantation) - PDF ...
This Practice Point analyzes the UNOS database for HIV-influenced patient survival rates after liver transplantation. ... Patients aged 18 years who had undergone liver transplantation, or multiple organ transplantation including the liver, between ... Cite this: What Is the Impact of HIV Infection on Survival After Liver Transplantation? - Medscape - Aug 01, 2008. ... HIV infection has not been considered a contraindication to orthotopic liver transplantation (OLT) since highly active ...
Research into the possibility of liver transplantation (LT) started before the 1960s with the pivotal baseline work of Thomas ... Liver transplantation. Retractors in place aid exposure in this case of polycystic liver disease with a very large liver. ... Acute-on-Chronic Liver Failure Before Liver Transplantation: Impact on Posttransplant Outcomes. Transplantation. 2011 Oct 27. ... encoded search term (Liver Transplantation) and Liver Transplantation What to Read Next on Medscape ...
Survival rates after liver transplantation have improved steadily because of earlier referral and timely evaluation, judicious ... Current indications and contraindications for liver transplantation Clin Liver Dis. 2007 May;11(2):227-47. doi: 10.1016/j.cld. ... Potential candidates for liver transplantation should meet minimal listing criteria and not have contraindications to liver ... Survival rates after liver transplantation have improved steadily because of earlier referral and timely evaluation, judicious ...
A new study of liver transplant centers confirms that non-Hispanic white patients get placed on liver transplant waitlists at ... Tags: Health Insurance, Hospital, Liver, Liver Disease, Liver Transplant, Liver Transplantation, Medicaid, Poverty, Primary ... Zarrinpar, A., et al. (2021) Racial Disparities in Liver Transplantation Listing. Journal of the American College of Surgeons. ... Patients need to be made aware earlier on that transplantation is a potential solution for certain liver conditions. If aware, ...
Living-donor transplantation holds the potential to save many of these lives, yet remains underused in the United States. ... Thousands of people die every year while waiting for a liver transplant. ... Living-donor liver transplantation is safe, saves lives, study shows. By Denise Mann, HealthDay News ... "Most recipients who are eligible for deceased-donor liver transplantation would be candidates for living-donor liver ...
... according to research presented at The Liver Meeting Digital Experience. ... Frailty was associated with worse outcomes in patients who underwent liver transplantation, ...
... a Johns Hopkins transplantation expert, answers frequently asked questions about live organ donation. ... Living donation does not change life expectancy. Most donors go on to live healthy lives after recovering from the surgery. ... answers frequently asked questions about live organ donation:. Who can become a living donor?. Living donors can be relatives, ... Living Organ Donation: Answers from Transplantation Expert Andrew Cameron. *Share on Facebook ...
Keywords have been corrected to: transplantation, chemoembolization, radioembolization, ablation. ... ERRATA CORRIGE - Significance of interventional radiology in liver transplantation. Vitorio Perić ; Department of Diagnostic ... V. Perić, et al., "ERRATA CORRIGE - Significance of interventional radiology in liver transplantation", Libri Oncologici, vol. ... "ERRATA CORRIGE - Significance of interventional radiology in liver transplantation." Libri Oncologici, vol. 50, no. 1, 2022, pp ...
Infection and Fungemia after Orthotopic Liver Transplantation Shanthi Kappagoda. , Jason Y. Adams, Robert Luo, Niaz Banaei, ... infection in a 55-year-old man who received an orthotopic liver transplant. A) Chest computed tomography scan showing right ... Infection and Fungemia after Orthotopic Liver Transplantation. ...
... living donor kidney transplantation (LDKT) is the treatment of choice. Yet, racial disparities in kidney transplantation ... Ready to change peoples lives? We want to hear from you.. We do more than solve the challenges our clients have today. We ... Abt Associates uses data and bold thinking to improve the quality of peoples lives worldwide. We partner with clients and ...
State-of-the-Art - Long-term outcomes in living.... Join us for the next ILTS State-of-the-Art webinar... ... Vanguard - Complex Liver Cases -.... ILTS is inviting you to the December 9th,... ... Fellowship Position in HPB & Transplantation. The HPB Transplant Fellowship is a 2-year clinical... ...
... liver resections and liver transplantations were performed by different surgical teams, with very little interplay between the ... split liver and living donor liver transplantation have become popular in the transplant community, utilizing the Coinaud ... In the past, liver resections and liver transplantations were performed by different surgical teams, with very little interplay ... This book offers a complete overview of the connections between liver transplantation and hepatobiliary surgery. It focuses on ...
Researchers from Israel have determined that more than half of liver transplant recipients develop post-transplantation ... Metabolic syndrome found in 52 percent of patients after liver transplantation. Jan 7, 2011 10:00 AM By Staff Reporter ... In an editorial also published this month in Liver Transplantation, Michael Charlton, MD, FRCP, from the Mayo Clinic Transplant ... Full details of this retrospective-prevalence study are available in the January 2011 issue of Liver Transplantation, a journal ...
Listen to the A History of Pediatric Liver Transplantation with George Mazariegos, MD podcast from UPMC Children's Hospital ... This has meant that weve needed to evolve expertise in techniques such as split liver transplantation and living related liver ... the most live donor liver transplants in the country for children as well as an active program in split liver transplantation ... to this field of liver transplantation generally is shown to require about 500 liver transplants in the country per year for ...
Background: Liver transplantation is now routine therapy for a variety of childhood liver diseases; however, there are no ... Pediatric liver transplantation is now routine therapy for irreversible acute or chronic liver disease and many inborn errors ... Transplantation for childhood liver disease: an overview. Liver Transpl Surg 1998;4(5 Suppl 1):S18-23. ... Pediatric liver transplantation with cadaveric or living related donors: comparative results in 90 elective recipients of ...
... week following liver transplantation for cirrhosis to determine the range of values in patients following liver transplantation ... In conclusion, a wide range of abnormalities occurs in the vessels of liver transplant recipients, which were not associated ... week following liver transplantation for cirrhosis to determine the range of values in patients following liver transplantation ... "Prospective Evaluation of the Role of Quantitative Doppler Ultrasound Surveillance in Liver Transplantation" Liver ...
Split-liver transplantation eliminates the need for living-donor liver transplantation in children with end-stage cholestatic ... Wan P, Li Q, Zhang J, Xia Q. Right lobe split liver transplantation versus whole liver transplantation in adult recipients: A ... Use of extended right grafts from in situ split livers in adult liver transplantation: a comparison with whole-liver ... Transplantation. 2003; 75(8):1197-1203.. *Cintorino D, Spada M, Gruttadauria S, et al. In situ split liver transplantation for ...
... therapeutic options for patients undergoing liver transplantation for hepatitis B have evolved to include HBV immune globulin ( ... and the International Liver Transplantation Society (ILTS).. Liver Transplantation is published on behalf of the societies by ... examined 15 years of data on outcomes after liver transplantation for recipients with hepatitis B-related liver disease. The ... Article: "Outcome of Liver Transplantation for Hepatitis B in the United States." W. Ray Kim, John J. Poterucha, Walter K. ...
... Dec 1, 1992 , Magazine: ... Transplantation Proceedings Eroles G, Maganto P, Cienfuegos JA, Rodríguez V, Santamaría L, Pardo F, Sierra E, Castillo-Olivares ...
In the U.S. alone, more than 16,000 people are allegedly waiting for a liver. Even ... The need for liver transplants has apparently grown over the years. ... Home Medical Research Novel substance appears helpful in transplantation of marginal livers ... In the U.S. alone, more than 16,000 people are allegedly waiting for a liver. Even transplanting a damaged liver may have its ...
Although we found that, overall, alcoholic liver disease became the leading indication for liver transplantation in the U.S. in ... Alcoholic Liver Disease Replaces Hepatitis C Infection as the Leading Cause of Liver Transplantation. ... now ranking second as a cause of liver transplantation due to chronic liver disease. ... One of our most worrying findings was that patients with ALD are being listed for liver transplantation at a much younger age ...
Transplantation) This half-day seminar is for Spanish speaking patients and families who are living with kidney disease or have ... transplantation, anti-rejection medicat, a blog by NKFI ... Viviendo con Enfermedad Renal y Trasplante (Living with Kidney ... Disease & Transplantation) This half-day seminar is for Spanish speaking patients and families who are living with kidney ... transplantation, anti-rejection medications, and more. Breakfast, lunch and parking are all included in the free registration. ...
Developing an ethics framework for living donor transplantation. Lainie F Ross et al., Journal of Medical Ethics, 2018 ... The cost of autonomy: estimates from recent advances in living donor kidney transplantation ... The cost of autonomy: estimates from recent advances in living donor kidney transplantation ... Join the Lone Kidney Club: incentivising live organ donation. Annet Glas, Journal of Medical Ethics, 2020 ...
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Demand for donor livers for transplant patients outstrips supply with over 15% of waitlist patients dying after a ... A new international study offers support for increasing the use of living donor liver transplantation (LDLT) in Western ... LDLT is when a portion of the liver from a healthy living person is removed and placed into someone whose liver is no longer ... Tags:Asia, Asian, Canada, Europe, european, health, healthcare, hepatology, international, liver transplant, living donor, ...
Saving More Lives Than Ever Before in 2021!. From the desk of Jennifer Prinz, Donor Alliance CEO ...
Perioperative thrombotic complications associated with pediatric liver transplantation: a UNOS database evaluation. HPB. 2019 ... Perioperative thrombotic complications associated with pediatric liver transplantation : a UNOS database evaluation. In: HPB. ... Dive into the research topics of Perioperative thrombotic complications associated with pediatric liver transplantation: a ... Perioperative thrombotic complications associated with pediatric liver transplantation : a UNOS database evaluation. / ...
  • The incidence of graft failure at 1 year is 7.9% for recipients of deceased-donor livers transplanted in 2019. (
  • In 2021, 9236 patients received a liver transplant and 12,800 patients were added to the waiting list for a liver transplant. (
  • In 2021, 9,236 liver transplants were performed: 8,667 from deceased donors and 569 from living donors, said Klassen, who was not involved in the new study. (
  • Saving More Lives Than Ever Before in 2021! (
  • Organ and tissue donation and transplantation activity report 2021/22. (
  • American Journal of Transplantation is cited by a total of 9110 articles during the last 3 years (Preceding 2021). (
  • The impact score (IS) 2021 of American Journal of Transplantation is 7.03 , which is computed in 2022 as per its definition. (
  • IS 2021 of American Journal of Transplantation is 7.03 . (
  • 20 reports of HBV infection among recipients of livers from were defined as unexpected, new,¶ reproducible laboratory donors who had no evidence of past or current HBV infection. (
  • Investigation included review of laboratory data and medical in liver recipients after transplantation that were reported to records. (
  • Recipients of a the Advisory Committee on Immunization liver from a donor with isolated total anti-HBc positive results can develop reactivation of hepatitis B after transplantation. (
  • Segmental transplantation allows two recipients to receive allografts from one cadaveric donor or allows for living-donor liver donation. (
  • Dr. Zarrinpar and colleagues analyzed deceased donor liver transplant and waitlist data obtained from the Scientific Registry of Transplant Recipients for 109 high-volume liver transplant centers (250 or more transplant operations over a five-year period from 2013 to 2018), excluding Veterans Affairs centers and Hospital Auxilio Mutuo in San Juan, Puerto Rico, because of its nearly 100 percent Hispanic population. (
  • Most recipients who are eligible for deceased-donor liver transplantation would be candidates for living-donor liver transplants," said study author Dr. Mark Cattral, surgical director of the Living-Donor Liver Transplantation Program at Toronto General Hospital in Canada. (
  • Organ rejection is a known risk for all transplants, which is why recipients take medication for the rest of their lives to make sure their body accepts the new organ or portion of the organ. (
  • The risk of rejection is similar in deceased and living-donor recipients," Cattral said. (
  • Researchers from Israel have determined that more than half of liver transplant recipients develop post-transplantation metabolic syndrome (PTMS), placing them at greater risk for cardiovascular disease. (
  • In conclusion, a wide range of abnormalities occurs in the vessels of liver transplant recipients, which were not associated with the development of vascular complications or affect patient management. (
  • The practice of splitting deceased donor liver allografts to provide liver transplants for two recipients from one deceased donor could ease this disparity by increasing the number of organs available for transplant. (
  • Historically, split liver transplantation has primarily benefited pediatric recipients who are too small to be transplanted with a full-sized liver (Appendix-2). (
  • At the same time, the outcomes for liver transplant recipients with hepatitis B improved dramatically, as detailed in a new study published in the August 2004 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). (
  • In light of these innovations, researchers, led by W. Ray Kim, M.D., of the Mayo Clinic, examined 15 years of data on outcomes after liver transplantation for recipients with hepatitis B-related liver disease. (
  • At the same time, liver transplant recipients with hepatitis B went from having significantly lower survival rates than those with other diagnoses, to having comparable, if not higher, survival rates. (
  • The two studies presented this week at the International Liver Congress™ 2018 in Paris, were conducted to evaluate recent trends in the etiology of liver disease among liver transplant recipients in the USA in view of the changing landscape of potential risk factors. (
  • According to the results of the study, the number of liver transplant recipients with HCV peaked in 2014 (1,905 individuals) and has been declining ever since. (
  • As in the first study, HCV infection remained the leading aetiology for liver transplant recipients until 2016, when ALD surpassed it, accounting for 24% of liver transplants performed compared with 19% for NASH and 18% for HCV. (
  • A special 1.5 km run for transplant recipients was also organized to celebrate their Second Chance to Live. (
  • We aimed to describe cases of SARS-CoV-2 infection among patients with chronic liver disease (CLD) and liver transplant (LT) recipients with at least one prior COVID-19 vaccine dose. (
  • In 2020, 66 liver transplants involved living donors, with most donors closely related to the recipients. (
  • Outcomes have shown continued improvement over the past decade among recipients of both deceased and living donor livers. (
  • We compared outcomes of deceased donor (DD) and living donor (LD) renal transplantation in AAs vs CAs in 772 recipients of first allografts at our transplant center from January 1995 to March 2004. (
  • Fatty infiltration of the liver is common in the brain-dead donor population and has a strong correlation with primary nonfunction after cold preservation, a condition that is catastrophic to liver transplant recipients. (
  • The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on the monitoring, management, and treatment of kidney transplant recipients is intended to assist the practitioner caring for adults and children after kidney transplantation. (
  • This pilot trial was designed to assess the safety and efficacy of SRL in liver transplant recipients with renal dysfunction. (
  • infection in a 55-year-old man who received an orthotopic liver transplant. (
  • Orthotopic liver transplantation was performed successfully. (
  • Application and success of orthotopic liver transplantation (OLT) has continued to grow, and liver transplantation has become accepted therapy for several causes of irreversible liver disease. (
  • We report a case of fatal disseminated infection after orthotopic liver transplantation caused by a novel Emmonsia sp. (
  • A 55-year-old man received an orthotopic liver transplant because of alcoholic cirrhosis. (
  • The armamentarium for managing HCC is wide and includes surgical resection, orthotopic liver transplantation (OLT), ablative techniques using ethanol (percutaneous ethanol injection, PEI), microwave (MWA) or radiofrequency (RFA), catheter-directed transarterial chemoembolization (TACE) or radioembolization (TARE), external beam radiation therapy in the form of stereotactic body radiation therapy (SBRT) or proton beam therapy (PBT), systemic targeted small molecule tyrosine kinase inhibitors, check-point inhibitor immunotherapy and investigational agents. (
  • 2022). 'ERRATA CORRIGE - Significance of interventional radiology in liver transplantation', Libri Oncologici , 50(1), pp. 44-44. (
  • Amsterdam, September 26, 2022 - Demand for donor livers for transplant patients outstrips supply with over 15% of waitlist patients dying after a year. (
  • As of May 2022, 194,777 liver transplants had been reported to the United Organ Sharing (UNOS) network since it created a national database in 1988. (
  • The liver is the second most commonly transplanted major organ, after the kidney. (
  • All live kidney and liver donations must be a completely voluntary decision. (
  • For most end-stage renal disease patients, living donor kidney transplantation (LDKT) is the treatment of choice. (
  • Yet, racial disparities in kidney transplantation persist. (
  • Kidney, Liver and Pancreas Transplant Support Group. (
  • Viviendo con Enfermedad Renal y Trasplante (Living with Kidney Disease & Transplantation) This half-day seminar is for Spanish speaking patients and families who are living with kidney disease or have had a kidney transplant. (
  • Background - Many patients with kidney failure will live longer and healthier lives if they receive a kidney transplant rather than dialysis. (
  • Design - This protocol describes a pragmatic 2-arm, parallel-group, open-label, registry-based, cluster-randomized clinical trial-the Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) trial. (
  • The following 4 unique steps per patient will be counted: (1) patient referred to a transplant center for evaluation, (2) at least one living kidney donor candidate contacts a transplant center for an intended recipient and completes a health history questionnaire to begin their evaluation, (3) patient added to the deceased donor transplant wait list, and (4) patient receives a kidney transplant from a living or deceased donor. (
  • Besides, Manipal Hospital's liver transplant team is experienced in various aspects of a liver transplant, such as deceased donor liver transplantation, living donor liver transplantation, and paediatric liver transplant, combined kidney and liver transplant, etc. (
  • AST/AJT Journal Club on "Pregnancy after living kidney donation, a systematic review. (
  • ASt/AJT Journal Club on "Simultaneous pancreas-kidney transplantation in Caucasian versus African American patients. (
  • To report a single-center 10-year experience of outcomes of kidney transplantation in African Americans (AAs) vs Caucasian Americans (CA) and to propose ways in which to improve kidney transplant outcomes in AAs, increased access to kidney transplantation, prevention of kidney disease, and acceptance of organ donor registration rates in AAs. (
  • The transplantation teams were notified of the test result, but the heart, liver, and one kidney had already been transplanted. (
  • Dr Lee is formally trained in liver transplants, kidney transplants and simultaneous pancreas kidney transplants in addition to complex hepatobiliary pancreatic surgery. (
  • He is accredited to perform transplant surgeries of the liver, kidney and pancreas. (
  • This guideline covers renal replacement therapy (dialysis and transplantation) and conservative management for people with chronic kidney disease stages 4 and 5. (
  • Kidney transplantation from a living donor, when available, is the treatment of choice for most patients with end stage renal disease, offering optimum patient and graft survival and reduced time on the national transplant waiting list. (
  • The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. (
  • The graft transplantation has been used in kidney failure as reliable and effective treatment option since 1936 (1). (
  • The approximate cost of kidney transplantation is $18,000 in India, $32,000 in Nigeria (the most active center), $78,000 in the UK and $117,000 in the US (6). (
  • Pancreas transplantation is most commonly performed in conjunction with a kidney transplant, a procedure referred to as simultaneous pancreas-kidney (SPK) transplantation. (
  • Alternatively, solitary pancreas transplants may be performed [ 5 ], usually in patients who have already had a kidney transplant often from a living donor: so-called pancreas after kidney transplants (PAK). (
  • Occasionally, both organs (distal pancreas segment and whole kidney) may come from a living donor [ 6 ]. (
  • This study is reported in the Journal of Hepatology , the official journal of the European Association for the Study of the Liver, published by Elsevier. (
  • Coming under the branch of Gastroenterology and Hepatology, Manipal Hospitals' Liver transplant program is the largest of its kind in the country. (
  • Background: This retrospective UNOS database evaluation analyzes the prevalence of preoperative portal vein thromboses (PVT), and postoperative thromboses leading to graft failure in pediatric patients undergoing liver transplantation (LT). Methods: The evaluation was performed in three age groups: I (0-5), II (6-11), III (12-18) years old. (
  • The Model of End-Stage Liver Disease (MELD) score, an accurate predictor of mortality in patients awaiting liver transplantation (OLTX), did not predict graft or patient survival in the post-transplant setting. (
  • Patient survival, graft survival, and interval liver biopsy pathology were reviewed. (
  • Graft failure rates for deceased and live donor liver transplantation are summarized in Table 1 below. (
  • CASE PRESENTATION We report a 20-year-old man who underwent split liver transplantation using a right trisegment and caudate lobe graft for EPP-induced liver failure , but succumbed to a deadly combination of early relapse of EPP and subsequent, intractable, late-onset bile leakage from the cut surface of segment 4. (
  • Split liver transplantation should preferably be avoided and appropriate post- transplant management is critical before protoporphyrin depositions to the bile duct and hepatocyte causes irreversible damage to the liver graft . (
  • Following pancreas transplantation, it is essential that any graft-related complications are diagnosed early to ensure prompt treatment and optimal survival of both graft and patient. (
  • 4 , 5 Many of these children are now in their second decade after surgery, and we report here results for more than 100 children who underwent transplantation between 1984 and 1999 with respect to their characteristics, processes of care, survival, complications and long-term outcomes (specifically steroid withdrawal and growth and development), and any effects related to the period in which they underwent surgery. (
  • We analyzed the findings of 51 consecutive patients who underwent DUS on 2 occasions in the first postoperative week following liver transplantation for cirrhosis to determine the range of values in patients following liver transplantation. (
  • METHODS: We conducted a retrospective study of all consecutive patients who underwent liver transplantation evaluation at a Swiss tertiary referral centre between January 2009 and March 2020. (
  • He then underwent stem cell transplantation 10 and 14 months after liver transplantation. (
  • Methods We used the Scientific Registry of Transplant Patients (2003-2015) to characterize 2352 adult patients who underwent 2408 status-1 liver transplants and compared them between Era1 (2003-6/2009) and Era2 (7/2009-2015). (
  • Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (
  • Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (
  • In this study, we investigated posttransplantational survival analysis of patients who underwent renal transplantation in Kyrgyzstan and other Eurasian, predominantly neighboring countries. (
  • Morbidity and Mortality Weekly Report archived donor serum, plasma, or liver biopsy samples were of nonliver organs** from the 20 donors developed a new tested for HBV DNA. (
  • The vast majority (95%) of liver transplants are from deceased donors. (
  • [ 2 ] Aggressive usage of extended donors and reduced-size, split, and living-related liver transplantation continues to expand the organ donor pool, though these efforts still fail to meet the need for organs. (
  • It showed that folks who undergo living-donor liver transplants do as well as people who receive tissue from deceased donors. (
  • Living donors can be relatives, friends, neighbors, in-laws or altruistic strangers (individuals who wish to donate to an unknown recipient purely out of selfless motives). (
  • Living donors must be at least 18 years old, in good physical and mental health, and must have a body mass index that is less than 35. (
  • For liver donors , the liver regenerates and regains full function. (
  • Most donors go on to live healthy lives after recovering from the surgery. (
  • The percentage of patients receiving reduced size grafts from adult donors, including live donors, increased from 2/32 (6%) in period 1 to 22/51 (43%) in period 3. (
  • More than 10% of all deceased donors, and more than 20% of donors less than 35 years old, meet these criteria, yet only less than 1.5% of all donor livers have been split since criteria adoption (Appendix-1). (
  • Bile ducts act as the liver's waste disposal system, and malfunctioning bile ducts are behind a third of adult and 70 percent of children's liver transplantations-there are currently no alternative treatments, which is a problem given the shortage of liver donors. (
  • The second edition of the British Transplantation Society Guidelines for Transplantation from Donors after Deceased Circulatory Death was published in June 2013. (
  • Only 0.5% pancreatic transplants are from living donors [ 1 ]. (
  • A new study of liver transplant centers confirms that non-Hispanic white patients get placed on liver transplant waitlists at disproportionately higher rates than non-Hispanic Black patients. (
  • In fact, Dr. Zarrinpar added, Medicaid covers liver transplant, and 'the vast majority of transplant centers will take public insurance. (
  • Although the study did not look at barriers to liver transplants for underserved populations, they could exist at any number of points along the care spectrum, Dr. Zarrinpar said, including transplant centers, referring centers, referring physicians, or even patients themselves. (
  • The patients may not have insurance at the time they develop their liver disease, but it's possible for the transplant centers to obtain coverage for people who are not just underserved but don't have the means,' he said. (
  • Fifty-six transplant centers have performed at least one living-donor liver transplant, with a majority performed at five transplant centers. (
  • The document should not be construed as a recommendation to require that all centers adopt split liver transplantation. (
  • Tacrolimus appears to be superior to cyclosporine in liver transplantation and is used in many centers. (
  • These were forwarded with the donated organs to the various transplantation centers. (
  • The donor's kidneys, heart, and liver were removed and transported to other medical centers for transplantation. (
  • PMR has presented a comprehensive report based on Bone Marrow Transplantation market as per End User (Hospitals, Multispecialty Clinics, and Ambulatory Surgical Centers), Disease Indication (Leukemia, Lymphoma, Myeloma, and Others), Transplant Type (Autologous Bone Marrow Transplant, and Allogeneic Bone Marrow Transplant) based on seven regions. (
  • If the transplantation was achieved by several countries in 1960s, now it is performed by vast majority of centers. (
  • Shortly, countries and transplantation centers demonstrates variation of survival estimations and risk ratios (2, 7, 8). (
  • Besides the general analysis of survival after renal transplantation, analysis by transplantation years and differences among countries was also included in our study. (
  • This is scarring of the liver, caused by injury or long-term disease. (
  • Data of eligible patients were extracted from the database for analysis, which included the evaluation of 19 pre-OLT recipient variables (including age, co-infection [with HCV or HBV] and model for end-stage liver disease (MELD) score) and 7 donor variables. (
  • In adults, the percentage of candidates with alcohol-associated liver disease rose from 22.2% in 2010 to 32.1% in 2020, making it the predominant indication for liver transplantation. (
  • Nonalcoholic fatty liver disease (NAFLD) has become the most common etiology of chronic liver disease in developed countries and is on trajectory to become the leading indication for liver transplantation in the United States. (
  • Indications and contraindications for liver transplantation are undergoing constant modifications with the goal of improving survival and functional status of patients who have end-stage liver disease or acute liver failure. (
  • Currently, the Model for End-stage Liver Disease score is used for organ allocation, but it may have future application in patient-selection criteria. (
  • During the procedure, a portion of a donor's liver is removed and transplanted into a person with liver disease. (
  • and the underlying liver disease itself (chronic hepatitis C virus infection and nonalcoholic fatty liver disease), all play a significant role in the development of metabolic syndrome. (
  • The largest bucket of those categories are children who present with liver failure from the complications of biliary atresia, and the second largest category are those that present with metabolic disease. (
  • What's interesting about these two big categories of overall disease types is that one really shows and exemplifies what we would think of as a child with liver disease. (
  • Pediatric liver transplantation is now routine therapy for irreversible acute or chronic liver disease and many inborn errors of metabolism. (
  • This priority is predicted by the Model for End-stage Liver Disease (MELD), or Pediatric End-stage Liver Disease (PELD) score, and most patients are critically ill before receiving priority for a liver transplant. (
  • Two independent studies have today reported that alcoholic liver disease has now replaced hepatitis C virus (HCV) infection as the leading cause of liver transplantation in the U.S. in patients without HCC. (
  • Non-alcoholic steatohepatitis (NASH) is also on the increase, now ranking second as a cause of liver transplantation due to chronic liver disease. (
  • In the first study, data from the United Network for Organ Sharing (UNOS) between 2005-2016 were analyzed, looking at four indications for chronic liver disease: alcoholic liver disease (ALD), NASH, HCV infection, and HCV/ALD combined. (
  • Although we found that, overall, alcoholic liver disease became the leading indication for liver transplantation in the U.S. in 2016, NASH was not far behind,' said Dr Jennifer Wang from the California Pacific Medical Center in San Francisco, who presented the study findings. (
  • Importantly, NASH is now the leading cause of liver transplantation in women, which is not entirely surprising given the higher rates of metabolic syndrome in women and the resultant increased risk of non-alcoholic fatty liver disease. (
  • One of our most worrying findings was that patients with ALD are being listed for liver transplantation at a much younger age and with more severe disease than patients with either HCV infection or NASH,' said investigator Dr. George Cholankeril from Stanford University Medical Center. (
  • So far, alcoholic liver disease has received much less attention with regards to clinical and basic research than either hepatitis B or C,' said professor Helena Cortez-Pinto from the University Hospital of Santa Maria in Lisbon, Portugal. (
  • BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is now the first cause of chronic liver disease in developed countries. (
  • Obesity, defined as a BMI ≥30 kg/m 2 by the World Health Organization (WHO), is the most common risk factor for the development of non-alcoholic fatty liver disease (NAFLD), followed by type 2 diabetes mellitus [8, 9]. (
  • In the meantime, NAFLD has become the most common chronic liver disease in many developed countries [11-14]. (
  • Barber K, Madden S, Allen J, Collett D, Neuberger J, Gimson A Elective liver transplant list mortality: development of a United Kingdom end-stage liver disease score. (
  • Schreibman I, Regev A Recurrent primary biliary cirrhosis after liver transplantation--the disease and its management. (
  • Dusk to Dawn, Chennai's First Night Marathon organized by The Centre for Liver Disease and Transplantation, Apollo Hospitals was a great success! (
  • The 'Dusk to Dawn Chennai Marathon 2014' was held on Saturday, 22nd November 2014, a first of its kind night marathon hosted in the city of Chennai by The Centre for Liver Disease & Transplantation. (
  • Autoimmune Liver Disease, Surgical Resection, and Liver Transplant for. (
  • Purpose: Despite antifungal prophylaxis following liver transplantation (LTX), patients are at risk for the development of subsequent opportunistic infections, such as an invasive fungal disease (IFD). (
  • SARS-CoV-2 Infections Among Patients With Liver Disease and Liver Transplantation Who Received COVID-19 Vaccination. (
  • This is the first reported patient with primary amyloidosis to undergo sequential liver and stem cell transplantation leading to resolution of the disease and only the second to undergo successful liver transplantation for this disorder. (
  • Conclusions: Surgical intervention to remove dental foci in liver disease patients requires careful clinical evaluation, laboratory tests, knowledge and skills in the use of local and systemic hemostatic procedures, and a partnership approach between dentists and physicians, in order to reduce the risk of complications. (
  • Liver transplantation has become accepted therapy for several causes of irreversible liver disease. (
  • Reappraisal of liver transplantation for erythropoietic protoporphyria: A deadly combination of disease recurrence and biliary complication. (
  • The Committee thanks the OPTN Ad Hoc Disease Transmission Advisory (DTAC) and Pediatric Transplantation Committees for their work on the proposal Pediatric Candidate Pre-Transplant HIV, HBV, and HCV Testing. (
  • Hepatitis is a liver disease which occurs due to the presence of inflammatory cells in your liver tissue. (
  • The main reason for this disease is group of hepatitis viruses which cause liver damage. (
  • It is an acute and self-limiting disease of the liver. (
  • By developing effective, well-tolerated treatments to cure HCV, we can halt the progression of this disease and save lives. (
  • If left untreated, HCV can lead to liver disease and cirrhosis of the liver. (
  • Despite the advent of effective antiviral drugs to eradicate hepatitis C infection, the prevalence of HCC is projected to increase secondary to increasing rates of fatty liver disease from diabetes and the obesity epidemic [ 2 ]. (
  • The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5-29.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not. (
  • Learn more about the connection between HHT and PH, disease management, signs and symptoms and more during this recorded Facebook Live event with Dr. Ali Ataya and Cure HHT Chief Medical Officer, Dr. Scott Olitsky. (
  • Prior to joining Gleneagles Hospital, Dr Lee was senior consultant and the former director of the Centre for Digestive and Liver Disease (CDLD) at the Singapore General Hospital from 2013 to 2015. (
  • LDLT is essential to bridge this gap and continues to be the main curative option for the majority of patients in India suffering from end-stage liver disease and Hepato cellular carcinoma (HCC) confined to the liver. (
  • In 1990, liver transplantation, the only effective treatment for end-stage liver disease was being performed in most of the Western world and Southeast Asia. (
  • Long-term follow-up of auxiliary liver transplantation for fulminant hepatic failure. (
  • We report on a patient with primary AL amyloidosis who presented with progressive liver failure secondary to hepatic infiltration in the absence of significant extrahepatic involvement. (
  • Hepatic steatosis and its relationship to transplantation. (
  • They may present with the signs or symptoms of what we would normally associate with a failing liver such bleeding and other complications. (
  • The second category though is much different and is really an evolving one because it includes conditions where sometimes the liver actually looks completely normal but is presenting with a missing enzyme or group of enzymes that cause significant complications. (
  • We reviewed data from the first 16 years of a pediatric liver transplantation program to determine survival, complications and long-term outcomes. (
  • A new effective treatment of hepatitis C not only combats the virus, but is also effective against potentially fatal complications such as reduced liver functioning and cirrhosis. (
  • Chelala L, Kovacs CS, Taege AJ, Hanouneh IA Common infectious complications of liver transplant. (
  • Craig EV, Heller MT Complications of liver transplant. (
  • Aim: To evaluate the invasive dental procedures for removing dental foci performed in patients scheduled for liver transplantation and its accompanying complications. (
  • Many of these patients will develop life threatening complications of decompensated cirrhosis or liver cancer and may require liver transplantation in the next decade," said Kuo. (
  • Through research come better HCV treatments and the ability to reduce complications such as cirrhosis and liver cancer. (
  • The outcomes to December 2000 for all children (age less than 18 years) who received a liver transplant at the London Health Sciences Centre between April 1984 and December 1999 were reviewed. (
  • Survival and long-term outcomes continue to improve for most children who receive liver transplants. (
  • Currently, about 1% of primary care physicians could encounter a child who needs or has received a liver transplant, but there is a paucity of information regarding the long-term outcomes of pediatric liver transplantation in Canada. (
  • The Committee does not believe that current liver allocation is optimal, because it neither takes into account post-transplant outcomes (an important metric of efficiency), nor does it maximize equitable distribution. (
  • He is also an advocate of the adoption of new surgical technology that can result in safer outcomes and quicker recovery for patients such as microwave ablation therapy for inoperable liver tumours. (
  • The traditional logic dictates that transplantation-related immunosuppression increases the risk of COVID-19 infection and entails sub-par clinical outcomes. (
  • These data underscore the importance of therapeutic innovations that have occurred incrementally in the past two decades for hepatitis B and support liver transplantation as an appropriate treatment for patients with acute and chronic insufficiency or HCC from HBV," the authors conclude. (
  • Chronic HCV infection has remained the leading indication for liver transplantation in the U.S. for the last two decades. (
  • Whereas chronic hepatitis C classically dominated the indications for liver transplantation in Europe and North America, the advent of direct-acting antivirals has dramatically changed the landscape of liver transplantation. (
  • Choudhary NS, Saigal S, Bansal RK, Saraf N, Gautam D, Soin AS Acute and Chronic Rejection After Liver Transplantation: What A Clinician Needs to Know. (
  • Dive into the research topics of 'Pretransplant MELD score as a predictor of outcome after liver transplantation for chronic hepatitis C'. Together they form a unique fingerprint. (
  • Pretransplant MELD score as a predictor of outcome after liver transplantation for chronic hepatitis C. / Onaca, Nicholas N. (
  • Liver transplantation is a treatment, used in appropriately selected patients, for acute and chronic liver failure due to any cause. (
  • Given the chronic shortage of donor organs, it's important to look at ways of repairing damaged organs, or even provide alternatives to organ transplantation," said Fotios Sampaziotis of the Wellcome-MRC Cambridge Stem Cell Institute. (
  • If untreated, it causes chronic liver cancer , which can lead to death. (
  • Most of the chronic illness will develop into liver cancer. (
  • Of those living with HCV, an estimated three million have chronic infections and one million are expected to develop cirrhosis of the liver by 2020. (
  • The current scenario is such that there is an increase in the adoption of Bone Marrow Transplantation procedures for treating various chronic diseases. (
  • Unlike other organs, the liver holds the potential to regenerate. (
  • Your doctors will evaluate your medical condition and the condition of your organs to determine if you are qualified to be a living organ donor. (
  • We investigated whether this protection requires human leukocyte antigen (HLA) matching between donor and recipient by exploiting the fact that, unlike transplantation of other solid organs, liver transplantation does not require HLA matching, but some donor and recipient pairs may nevertheless be matched by chance. (
  • In order to help to meet the demand for organs, he has tirelessly raised awareness of the importance of organ transplantation and enhanced its social acceptability through a holistic approach to family and community health, in particular with families of patients with terminal conditions and with religious leaders. (
  • Scientists were able to use lab grown bile ducts to repair damaged mouse livers and in donor human livers cultured outside of the body demonstrating, for the first time, that that lab grown organoids could be used in regenerative medicine to repair damaged donor organs making liver transplants more accessible - more work needs to be done before this can move to the clinic though. (
  • The mission of ECTORS is to provide a forum for discussing and stimulating novel developments in the fields of cellular therapies in organ transplantation, organ regeneration and generation of new organs from stem cells and biomaterials. (
  • While Deceased donor liver transplants (DDLTs) have picked up steam in Southern India, there is still a large gap between demand and supply of organs. (
  • A committee set up by the Minister of Health to examine this issue and several meetings were held all across India and also based on Singhvi committee recommendations, the Transplantation of Human Organs Bill was passed by Parliament in the year 1994 and became the law in 1995. (
  • In 2020, 502 pediatric liver transplants were performed in the United States, the lowest number in the past decade and a decrease of 8.9% from 2019. (
  • American Journal of Transplantation IS is increased by a factor of 2.71 and approximate percentage change is 62.73% when compared to preceding year 2020, which shows a rising trend. (
  • Biliary atresia was the most common indication for liver transplantation (57 [49%] of the 116 patients). (
  • Primary sclerosing cholangitis (PSC) is a common indication for liver transplantation (LT). Up to 25% of patients experience recurrence of PSC (rPSC) after LT, which is associated with significant morbidity and mortality. (
  • Biliary atresia remains a common indication for liver transplantation in pediatric patients. (
  • The prevalence of decompensated cirrhosis is predicted to increase by 180% (to 376,100 cases), resulting in an estimated increase of 59% in liver transplant cases (reaching 7,610 by 2030). (
  • A worrisome feature is that hepatocellular carcinoma can even develop in individuals with NAFLD who do not have advanced liver fibrosis or cirrhosis [16, 17]. (
  • Until recently, the leading indication for liver transplantation in the United States was HCV, which accounted for approximately 30% of new waitlist registrations. (
  • [ 2 ] Acute liver failure from hemochromatosis, leading to a histologic diagnosis of giant-cell hepatitis, is the primary indication for liver transplantation in the neonatal population. (
  • Domino donation occurs when an individuals undergoes liver transplantation as treatment for a medical problem (eg, familial amyloidosis) but the liver is suitable for transplant to another candidate. (
  • The tide may be turning on liver donation. (
  • Living donation does not change life expectancy. (
  • As a member of the donation and transplant community you have an impact on the lives of these people every day. (
  • Donor Alliance: Saving lives through organ & tissue donation and transplantation. (
  • Organ and tissue donation saves lives. (
  • Global Observatory on Donation and Transplantation. (
  • It is an initiative to create awareness among people about liver diseases, liver wellness and Organ Donation. (
  • This article´s objective is to reflect about organ donation in living donor transplantation. (
  • The Young Professionals in Transplantation (YPT) is the Network for Junior Transplant professionals of ESOT, representing all young transplant clinicians and scientists who are beginning a career in transplantation and organ donation. (
  • EDTCO aims to support health care professionals to provide clinically effective programmes on organ and tissue donation, procurement and transplantation. (
  • Informed consent to living organ donation -- Ch. 8. (
  • Using this technology, they demonstrated for the first time that it is possible to transplant biliary cells grown in the lab into damaged human livers to repair them. (
  • In order to determine the prevalence and risk factors associated with PTMS, Professor Ziv Ben Ari and colleagues from the Liver Transplant Unit at Rabin Medical Center-the largest such unit in Israel-reviewed the files of 252 patients who received a liver transplant between 1985 and 2007. (
  • Cite this: What Is the Impact of HIV Infection on Survival After Liver Transplantation? (
  • Because injection drug or HBV DNA) in an organ recipient without evidence for HBV infection (anti-HBc, HBsAg, or HBV DNA) preceding transplantation. (
  • unexpected, donor-derived HBV infection among liver recipi- ents. (
  • Ueda Y, Kaido T, Okajima H Long-term prognosis and recurrence of primary sclerosing cholangitis after liver transplantation: a single-center experience. (
  • Potential candidates for liver transplantation should meet minimal listing criteria and not have contraindications to liver transplantation. (
  • Before the arrival of HBIG and lamivudine, people with hepatitis B were poor candidates for liver transplantation, because the virus almost always infected and destroyed their new organ. (
  • Hepato-pancreato-biliary surgery involves a surgical procedure of the liver, gallbladder and the pancreas. (
  • Manipal Hospital is the best Liver transplantation and hepato-pancreato-biliary surgery hospital in Baner Pune specialised in the diagnosis and surgical management of an array of disorders related to the pancreas, bile ducts, liver, and gallbladder. (
  • He specialises in surgery for liver tumours, major pancreatic surgery and biliary surgery. (
  • abstract = "Background Approximately 5% of liver transplants annually are performed urgently with {"}status-1{"} designation. (
  • Mukherjee S, Mukherjee U A comprehensive review of immunosuppression used for liver transplantation. (
  • Pillai AA, Levitsky J Overview of immunosuppression in liver transplantation. (
  • The predictors of recurrent autoimmune hepatitis (R-AIH) after liver transplantation (LT) are heterogeneous with limited data to guide immunosuppression, with little data on impact of race. (
  • Immunosuppression during liver transplantation (LT) enables the prevention and treatment of organ rejection but poses a risk for severe infectious diseases. (
  • [ 3 ] Survival of the allograft and the patient is made possible by immunosuppression following transplantation. (
  • The ISSN of American Journal of Transplantation journal is 16006135, 16006143 . (
  • Acute infections are often short-lived and resolved within a few weeks. (
  • The London Health Sciences Centre is the principal pediatric liver transplant referral centre for the Atlantic provinces, Manitoba and British Columbia, as well as southwestern Ontario. (
  • It is published by Wiley-Blackwell Publishing Ltd . The overall rank of American Journal of Transplantation is 506 . (
  • Year wise Impact Score (IS) of American Journal of Transplantation. (
  • Survival rates after liver transplantation have improved steadily because of earlier referral and timely evaluation, judicious patient selection, improved surgical techniques, superior immunosuppressive regimens, and effective prevention of perioperative opportunistic infections. (
  • For the study, the researchers looked at how well people fared after nearly 3,000 living-donor liver transplants in the United States, Canada and the United Kingdom, and the long-term survival was "excellent. (
  • Michele Molinari, MD, MSc, FACS, reviews unresectable metastatic colorectal cancer statistics and explains how liver transplantation can improve survival rates. (
  • Conclusions Liver transplantation for the most urgent indications (status-1) is decreasing while survival remains excellent. (
  • Over the last 17 years, liver transplant in India has evolved from a rarity to a common procedure available along the length and breadth of the country with survival data comparable to the best centres in the world. (
  • Studies show the increase in survival rate by transplantation in comparison to hemodialysis (2-4). (
  • On the background of technological modernizations, surgical achievements, survival improvements the transplantation was further motivated by healthcare institutions. (
  • Preoperative PVT at the time of transplantation was independently associated with postoperative thromboses. (
  • Pediatric liver transplantation was first performed at the University of Western Ontario in 1984 as part of a combined adult-pediatric program. (
  • Millson C, Considine A, Cramp ME Adult liver transplantation: a UK clinical guideline - part 1: pre-operation. (
  • Millson C, Considine A, Cramp ME Adult liver transplantation: UK clinical guideline - part 2: surgery and post-operation. (
  • Certican was approved by European Health Authorities under the tradename Ceritcan for the prophylaxis of organ rejection in adult patients receiving a liver transplant in October 2012, and a decision by US regulators is expected by the end of the year. (
  • Since the early 1990s, therapeutic options for patients undergoing liver transplantation for hepatitis B have evolved to include HBV immune globulin (HBIG) and lamivudine. (
  • Still, they report that the outcome of liver transplantation for patients with hepatitis B has improved significantly over the past 17 years, commensurate with therapeutic innovations introduced during the same period. (
  • Article: "Outcome of Liver Transplantation for Hepatitis B in the United States. (
  • Types of Hepatitis Viruses And How They Affect On Your Liver Tissues! (
  • A collaborative partnership between the UC San Diego Liver Center and Antiviral Research Center (AVRC) has resulted in 19 clinical trials for hepatitis C virus (HCV), focused on developing more effective and well-tolerated HCV treatments. (
  • The Liver Center provides patients outstanding patient care through its Hepatitis Clinic and Transplant Program," said Kuo, a lead researcher in the HCV clinical trials. (
  • Severe protoporphyric hepatopathy results in liver failure , requiring both liver and bone marrow transplantation as a life -saving procedure and to correct the underlying enzymatic defect, respectively. (
  • This scenario is, by all means, favoring the Bone Marrow Transplantation market growth. (
  • Furthermore, favorable reimbursement policies are also expected to contribute to the growth of the European Bone Marrow Transplantation Market. (
  • There has been a growing interest in strategies to alleviate the increasing demand for transplantation and the unacceptably high mortality on the liver transplant waitlist," explained Gonzalo Sapisochin, MD, PhD, MSc, Division of General Surgery, University Health Network, Toronto, ON, Canada. (
  • The association of mortality states and years of transplantation found significantly by Kaplan-Meier test (Breslow p˂0.001). (
  • The second study presented today also evaluated data from the UNOS registry, looking at first liver transplants performed in individuals without HCC between January 2012 and October 2017. (
  • Of the 116 patients, 23 (20%) were less than 1 year old at the time of transplantation. (
  • The number of patients surviving to 1 year after transplantation was 20 (69%) of the 29 patients from period 1, 40 (87%) of the 46 patients from period 2 and 38 (93%) of the 41 patients from period 3. (
  • infections were detected a median of 38 from the same donor as the liver recipient were evaluated for (range = 5-116) weeks after transplantation. (
  • A blood specimen collected 10 weeks after transplantation was positive for HIV antibody by EIA, and a specimen collected 1 week later was positive by both EIA and Western blot assay. (
  • Professor Haberal, the Founder and President of Bakent University in Ankara, Turkey, is also the Founder and President of the Institute of Transplantation and Gene Sciences and Chair of the Division of Transplantation at Bakent University, and the recipient of multiple global distinctions and awards. (
  • 1. Cadaveric organ donor transplantation -- Ch. 1. (
  • Pancreas transplantation is a surgical treatment for diabetes mellitus. (
  • Pancreas transplantation is a surgical treatment for diabetes mellitus (DM). (
  • Less than 10% involve pancreas transplantation alone (PTA). (
  • However, the availability of second-generation direct-acting antiviral agents (DAAs) in late 2013 led to a decline in the number of HCV-related liver transplant waiting list registrations and surgeries from 2015 onwards. (
  • This study aims to determine if the demand, characteristics, and outcome for status-1 liver transplantation has changed over time. (
  • Patients aged 18 years who had undergone liver transplantation, or multiple organ transplantation including the liver, between January 1997 and October 2006 were identified for inclusion in the study. (
  • Just like with any other major surgery, there are risks and a period of critical recovery time for transplantation surgery. (
  • He's also the Director of Pediatric Transplantation at the Thomas Starzl Transplantation Institute, and he's a Professor at the University of Pittsburgh in the Departments of Surgery, Anesthesiology and Critical Care Medicine. (
  • The donor's remaining liver regrows and returns to its normal size, volume, and capacity within a few months after the surgery. (
  • Manipal Hospital has the most advanced technology in cancer surgery, including intraoperative ultrasound (IOUS), cavitron ultrasonic aspirator and dissector (CUSA) for the liver parenchymal transaction, argon plasma coagulator (APC), harmonic scalpel, and ligature. (
  • Advances in pharmacology and surgery techniques have made possible the transplantation of a range of body parts from a donor body into the living body of a recipient. (
  • Professor Haberal is a pioneer in the field of general surgery, organ transplantation and burn treatment in Turkey and in the world, having practised since 1975. (
  • VCA has opened a new era in the field of transplantation, reconstructive and restorative surgery. (
  • He has been an invited speaker for many international and regional conferences for liver surgery and laparoscopic surgery. (
  • In addition, he has performed single-site "scarless" surgery in live demonstrations on numerous occasions. (
  • The intervention includes any type of liver surgery. (
  • In addition, liver allocation often prioritizes patients with standardized "exception points" due to hepatocellular carcinoma, hepatopulmonary syndrome, and portopulmonary hypertension, and there is published evidence that non-standardized exception points are not awarded consistently region to region or by race 1,2 . (
  • In African Americans and those with hepatocellular carcinoma, HCV remains the leading cause of transplantation and a major burden. (