A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
Demographics of Afghanistan
School life expectancy (primary to tertiary education). total: 11 years male: 13 years female: 8 years (2014) ... Live births per year Deaths per year Natural change per year CBR1 CDR1 NC1 TFR1 IMR1 ... HIV/AIDS - people living with HIV/AIDS. Up to 6,900 (2015 estimate) ... Approximately 46% of the population is under 15 years of age, and 74% of all Afghans live in rural areas. The average woman ...
Cystic fibrosis transmembrane conductance regulator
April 1992). "Primary hepatocellular carcinoma with severe hypoglycemia: involvement of insulin-like growth factors". Liver. 12 ... The CFTR is found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, and the female ... McPhail GL, Clancy JP (April 2013). "Ivacaftor: the first therapy acting on the primary cause of cystic fibrosis". Drugs of ...
Primary target organ in mammals Cyanobacteria genera Cyclic peptides Microcystins Liver Microcystis, Anabaena, Planktothrix ( ... They are hepatotoxic and can cause serious damage to the liver in humans. In this way they are similar to the nodularins ( ... Individual phytoplankton rarely live more than a few days, but blooms can last weeks. ... Cylindrospermopsin is toxic to liver and kidney tissue and is thought to inhibit protein synthesis and to covalently modify DNA ...
... (AP62A) are found in a primary biliary cirrhosis. The p62 protein is also more frequent in Stage IV primary ... Liver Dis. 25 (3): 298-310. doi:10.1055/s-2005-916321. PMID 16143945.. ... Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". ... 2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis ...
E3 binding protein
Primary biliary cholangitis eventually leads to liver failure. The mRNA encoded by the human PDHX gene is approximately 2.5 kb ... These autoantibodies are present in nearly 95% of patients with primary biliary cholangitis, an autoimmune disease of the liver ... progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure. Click on ... In primary biliary cholangitis, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein ...
Hempel J, von Bahr-Lindström H, Jörnvall H (May 1984). "Aldehyde dehydrogenase from human liver. Primary structure of the ... Hempel J, Kaiser R, Jörnvall H (Nov 1985). "Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, ... In the liver, the enzyme alcohol dehydrogenase oxidizes ethanol into acetaldehyde, which is then further converted into the ... As discovered by site-directed mutagenesis, glutamate-268 is a key component of liver acetaldehyde dehydrogenase and is also ...
Strapping Young Lad
Live performances. Townsend's unique "Skullet" hairstyle and aggressive stage persona have made him "one of the more ... Townsend was the band's primary songwriter. While the first two albums were solely his work, subsequent albums featured a ... In June 1998, the group released No Sleep 'till Bedtime, a live album containing songs performed at a 1997 performance at the ... A career spanning best of album, entitled 1994-2006 Chaos Years, was released on March 31, 2008, with a bonus DVD of live ...
Liver Physiol. 289 (3): G462-70. doi:10.1152/ajpgi.00494.2004. PMID 15677552. Saavalainen K, Pasonen-Seppänen S, Dunlop TW, et ... 2005). "The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene". J. Biol. ...
Yu S-Z (1989). "Drinking water and primary liver cancer". In Z.Y. Tang; M.C. Wu; S.S. Xia (eds.). Primary Liver Cancer. New ... They are hepatotoxic, i.e., able to cause serious damage to the liver. Once ingested, microcystin travels to the liver via the ... endemic areas of primary liver cancer in China, by highly sensitive immunoassay". Carcinogenesis. 17 (6): 1317-21. doi:10.1093/ ... A few studies suggest a relationship may exist between liver and colorectral cancers and the occurrence of cyanobacteria in ...
... treatment of primary biliary cirrhosis and treatment of viral hepatitis. Her scientific contributions to liver disease have ... Jenny Heathcote to be honoured Oct 30 at a Farewell Symposium". Canadian Liver Foundation. 3 October 2013. "UHN Global Impact ... Dooley, James S.; Lok, Anna; Burroughs, Andrew K.; Heathcote, Jenny (2011). Sherlock's Diseases of the Liver and Biliary System ... Lindor, Keith D.; Heathcote, E. Jenny; Poupon, Raoul E. (2012). Primary Biliary Cirrhosis: From Pathogenesis to Clinical ...
Newton, JL (May 2008). "Fatigue in primary biliary cirrhosis". Clin Liver Dis. 12 (2): 367-83. doi:10.1016/j.cld.2008.02.010. ... Fellow of the Royal College of Physicians European Association for the Study of the Liver, Travel Fellowship, 2002. Jones, D.E. ... Her published research has been chiefly on the autonomic nervous system and its relation to disease especially in primary ... Newton, J.; Francis, R.; Prince, M.; James, O.; Bassendine, M.; Rawlings, D.; Jones, D. (2001). "Osteoporosis in primary ...
In about half of people who are hospitalized or seen at a primary care clinic there is no documented reason for their long-term ... Strand DS, Kim D, Peura DA (January 2017). "25 Years of Proton Pump Inhibitors: A Comprehensive Review". Gut and Liver. 11 (1 ... Various adverse outcomes have been associated with long-term PPI use in several primary reports, but reviews assess the overall ... "Pantoprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved ...
2. The primary structure of the gamma 1 protein chain". European Journal of Biochemistry / FEBS. 145 (3): 447-53. doi:10.1111/j ... Höög JO, Hedén LO, Larsson K, Jörnvall H, von Bahr-Lindström H (Sep 1986). "The gamma 1 and gamma 2 subunits of human liver ... Bühler R, Hempel J, Kaiser R, de Zalenski C, von Wartburg JP, Jörnvall H (Dec 1984). "Human liver alcohol dehydrogenase. ... Lange LG, Sytkowski AJ, Vallee BL (Oct 1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic ...
West J, Wood H, Logan RF, Quinn M, Aithal GP (June 2006). "Trends in the incidence of primary liver and biliary tract cancers ... People with chronic liver disease, whether in the form of viral hepatitis (e.g. hepatitis B or hepatitis C), alcoholic liver ... Certain parasitic liver diseases may be risk factors as well. Colonization with the liver flukes Opisthorchis viverrini (found ... "Incidence of primary cholangiocellular carcinoma of the liver in Japanese patients with hepatitis C virus-related cirrhosis". ...
Inflammatory bowel disease
The most relevant mechanisms of elevated liver functions tests in IBD are drug-induced hepatotoxicity and fatty liver. The ... Broomé U, Bergquist A (February 2006). "Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer". Seminars ... many sufferers lead relatively normal lives. Although living with IBD can be difficult, there are numerous resources available ... Live bacteria might not be essential because of beneficial effects of probiotics seems to be mediated by their DNA and by ...
Jörnvall H, Harris JI (April 1970). "Horse liver alcohol dehydrogenase. On the primary structure of the ethanol-active ... The enzyme is present at high levels in the liver and the lining of the stomach. It catalyzes the oxidation of ethanol to ... In the commonly studied horse liver isoform, Thr-48 is a Ser, and Leu-319 is a Phe. The zinc coordinates the substrate (alcohol ... Brändén CI, Eklund H, Nordström B, Boiwe T, Söderlund G, Zeppezauer E, Ohlsson I, Akeson A (August 1973). "Structure of liver ...
Ysgol Gymraeg Treganna, a Welsh-medium primary school, is on the northern edge of the park. Lansdowne Hospital was located to ... "Living". ishare.cardiff.gov.uk. Retrieved 2020-06-11. "Ely Trail". Outdoor Cardiff. Retrieved 2020-06-11. "Contact". Ysgol ... The pitch is used by Fitzalan High School and by Ysgol Gymraeg Treganna, the local primary school. Internet Publishing Team. " ...
Live! At Nick's Fat City, 1998 (Primary) Ah! Live!, 2009 (Primary) Live Bootleg, 2014 (Primary) 20th Century Masters: The ... It was followed in 2009 with their second live album, Ah! Live!, recorded at shows in Erie and Kittanning, Pennsylvania. In an ... Primary) WDVE Pittsburgh Rock 'n Roll '89, 1989 (WDVE-FM) on the song "Reach Out" Live at Blossom, 1981 King Cool: Ah! History ... A collection of tracks played at Nick's Fat City, a popular Pittsburgh nightclub, Live! At Nick's Fat City was the first ...
New Japan Philharmonic
The Philharmonic's primary concert venue is the Sumida Triphony Hall. From 2003 to 2013 its music director was Christian Arming ... The orchestra has done live performances with various musicians, notably Yngwie Malmsteen and his Concerto Suite in Eb Minor. ... Melee orchestral arrangement soundtrack Smashing...Live!, Resident Evil's music in Resident Evil Orchestra, orchestral ...
Hempel J, von Bahr-Lindström H, Jörnvall H (May 1984). "Aldehyde dehydrogenase from human liver. Primary structure of the ... Hempel J, Kaiser R, Jörnvall H (Nov 1985). "Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, ... In the liver, ethanol is converted into harmless acetic acid (the main acid in vinegar) by a two-step process. In the first ... Wang X, Weiner H (Jan 1995). "Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde ...
2014 United States Senate elections
Louisiana uses a unique jungle primary system that eschews primaries in favor of run-off elections between the top two ... M Live. Egan, Paul (June 4, 2013). "Republican Terri Lynn Land joins U.S. Senate race". Detroit Free Press. "Official Election ... Blake, Aaron (April 23, 2013). "Hanabusa will challenge Schatz in Hawaii Senate primary". The Washington Post. "Hawaii Primary ... "Dave Domina Wins Nebraska Senate Primary". The Huffington Post. May 13, 2014. "Unofficial Results: Primary Election - May 13, ...
Charlene, Princess of Monaco
"Charlene Wittstock remembered at former primary school". Times LIVE. Archived from the original on 6 July 2011. Retrieved 2 ... In 2012, Princess Charlene became the patron of AS Rugby Monaco and also the honorary president of Monaco Liver Disorder and ... She attended Tom Newby Primary school in Benoni, near Johannesburg, from 1988 to 1991. Wittstock won three gold medals and a ... "using the power of sport to change lives". In July 2011, Princess Charlene became a co-patron of Giving Organisations Trust, a ...
Matthew Humberstone School
"Closed: Bursar Primary School". Ofsted. Retrieved 5 December 2019. "Bursar Primary Academy". Ofsted. Retrieved 5 December 2019 ... Grimsby Live. Grimsby Telegraph. Retrieved 25 November 2019. Note: Relative locations of the two sites can be seen in Google ... Ofsted records the Bursar Primary School as being closed in 2010, and Bursar Primary Academy opened in August 2012, with ... The primary school opened in September 2018 on the site of what used to be Humberstone Foundation School with an initial ...
"New Huntington Primary School taking shape". Cheshire Live. 12 February 2018. Retrieved 29 April 2018. "New £7m Chester primary ... "New Huntington primary school planned on green belt land". Cheshire Live. 2 February 2017. Retrieved 12 April 2017. " ... Wales national football team manager Gary Speed, born just over the Welsh border in Mancot, lived at a house in the village at ... The village includes a few shops, a post office, Huntington Primary School and St Luke's Church of England Church. Recreational ...
"Is Bentonville The South's Next Cultural Mecca?". Southern Living. Retrieved 2018-05-15. "Primary Distinguishing ... In 2010, CNN Money magazine ranked Rogers as the 10th Best Place to Live in the United States. Two of the city's biggest ... Business insider named Fayetteville the 2nd best place to live in the South in 2016. Springdale is a city in Washington and ... Southern Living magazine recently cited Bentonville as "the South's next cultural mecca." Bentonville Downtown Fayetteville ...
2020 United States House of Representatives elections in Massachusetts
"Massachusetts primary election: U.S. House candidates James McGovern and Tracy Lovvorn on the issues". Mass Live. August 27, ... Primary elections were held on September 1. The 1st district is based in the western and central parts of the state, and ... Neal primary heats up". "Our Endorsements". DMFI PAC. "JStreetPAC Candidates". JStreetPAC. "Our Opinion: Re-elect U.S. Rep. ... In the Democratic primary, lawyer and ten-term incumbent Lynch defeated progressive challenger Robbie Goldstein, a medical ...
2020 Pennsylvania Attorney General election
Primary elections were originally due to take place on April 28, 2020. However, following concerns regarding the COVID-19 ... Penn Live. "An Updated Look at Handicapping the 2020 Attorney General Elections". The Cook Political Report. Retrieved July 17 ... Gerow, Charlie (May 24, 2020). "An introduction to the GOP candidates for statewide offices as primary day approaches , Charlie ... "Pennsylvania lawmakers vote to delay primary election". AP NEWS. Retrieved March 28, 2020. Southwick, Ron. "Josh Shapiro ...
Wallace and Gromit
Wallace lives at 62 West Wallaby Street, Wigan, along with his dog Gromit. His surname is never given. He usually wears a white ... https://twitter.com/ITV/status/1061242075209854976[non-primary source needed] "DFS "The grand sofa caper" by Krow". Campaign ... The four episodes have separately been released on Xbox Live Arcade for the Xbox 360. There is also several games on the ... On 9 March 2011, Shaun the Sheep made its live theatre début in Shaun's Big Show. The 100-minute-long musical/dance show ...
St Paul's Primary School was founded in 1860. St Joseph's Catholic Primary School was founded in 1873 by Augusta Fitzalan- ... He continued to live in the town until his death in 1954 and is buried in the cemetery. People born in the town include: ... St Martin's Primary School was founded as a National School by the vestry in the 1830s, however there is thought to have been a ... St John's Primary School was founded in 1955 on the Goodwyns housing estate to the south of the town. It was known as The ...
A DVD and 10-track live album, titled Live & Off the Record, was also released in 2004, commemorating the Tour of the Mongoose ... Retrieved 19 October 2017.[non-primary source needed] "Por conta de problemas de saúde, Shakira adia vários shows de sua turnê ... Shakira's first live album, MTV Unplugged, was recorded in New York City on 12 August 1999. Highly acclaimed by American ... To instill gratitude in Shakira for her upbringing, her father took her to a local park to see orphans who lived there. The ...
Socialist Sunday School
The primary publication of the Socialist Party's youth movement was a monthly magazine called Young Socialist's Magazine, ... Look forward to the day when all men and women will be free citizens of one fatherland and live together as brothers and ... The primary Socialist Sunday School movement in the United States was that connected with the country's largest socialist ...
Primary microcephalyEdit. Primary microcephaly shows a clinical image of craniosynostosis, but due to a different cause. The ... It is estimated that craniosynostosis affects 1 in 1,800 to 3,000 live births worldwide. 3 out of every 4 cases affect males ... The primary goal of surgical intervention is to allow normal cranial vault development to occur. This can be achieved by ... The appearance can be the same as that seen with primary microcephaly: a markedly small head, but with normal proportions. ...
... and results in short-lived cells that secrete IgM antibodies. The T cell-dependent processes are subdivided into primary and ... produces short-lived cells that remain in the extramedullary regions of lymph nodes; a secondary response produces longer-lived ... Recently they have been shown to reside for much longer periods in the bone marrow as long-lived plasma cells (LLPC). They ... Primary amyloidosis (AL) is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cells ...
Of the 23,483 households, 39.2% had children under the age of 18 living with them, 52.9% were married couples living together, ... Primary and secondary schools. Baytown is served by the Goose Creek Consolidated Independent School District. Based in ... Finding inspiration in Peter Kageyama book Love Where You Live, the committee's vision for this program is to create emotional ... About 23.0% of all households were made up of individuals, and 8.0% had someone living alone who was 65 years of age or older. ...
T细胞 - 维基百科，自由的百科全书
CMV Primary Infection Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver ... Alpha-lactose reverses liver injury via blockade of Tim-3-mediated CD8 apoptosis in sepsis. Clinical Immunology. July 2018, 192 ... Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. The Journal of Experimental Medicine. ... Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to ...
Reunion (genealogy software)
This article relies too much on references to primary sources. Please improve this by adding secondary or tertiary sources. ( ...
I noticed you put him under living people-do we have any sources of him being still alive? (Well some people put living people ... How about creating a new page called poly athlete that doesn't have such a high requirements for the primary sport but takes in ... You are welcome to check how many page hits the article got while on the front page (here's how, live views, daily totals), and ... Using an asterisk against his name is original research and defamatory (see also our policy on biographies of living persons). ...
Type 2 diabetes
... liver, and fat tissue. In the liver, insulin normally suppresses glucose release. However, in the setting of insulin ... "Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes ... Metformin should not be used in those with severe kidney or liver problems. ... resistance, the liver inappropriately releases glucose into the blood. The proportion of insulin resistance versus beta ...
... saw rising incomes and improved standards of living but the primary beneficiaries were the wealthy. ... Labor Relations: Major Issues in American History (2005) over 100 annotated primary documents excerpt and text search ... During these 40 years, the primary aim of the labour unions was not to benefit the workers, but to carry out the state's ... the first long-lived national trade union center. By this time, the existence and the demands of the trade unions were becoming ...
They advertise their unique educational curricula in order to attract white students who do not live in the surrounding area. ...
For humans, eating is an activity of daily living. Some individuals may limit their amount of nutritional intake. This may be a ... eating is in fact the primary purpose of a social gathering. At many social events, food and beverages are made available to ... There are short-term signals of satiety that arise from the head, the stomach, the intestines, and the liver. The long-term ... The brain checks for glucoprivation on its side of the blood-brain barrier (since glucose is its fuel), while the liver ...
Harold E. Palmer
"The learners' task is to acquire these ergons or 'primary matter' as a database which will then serve them to generate many ... During World War II he lived in England, and assisted the war effort with his language skills, publishing three booklets about ...
Phytoplankton live just a few days, whereas the zooplankton eating the phytoplankton live for several weeks and the fish eating ... The base of the food chain (primary producers or detritivores) is set at zero. Ecologists identify feeding relations and ... Groombridge, B.; Jenkins, M. (2002). World Atlas of Biodiversity: Earth's Living Resources in the 21st Century. World ... Food webs depict the pathways of mineral nutrient cycling as they flow through organisms. Most of the primary production ...
United States Merchant Marine Academy
A disastrous fire in 1934 aboard the passenger ship SS Morro Castle, in which 134 lives were lost, convinced the U.S. Congress ... MARAD transferred the ship to the Texas Maritime Academy in Galveston to serve as its new primary training vessel. This was ... One hundred and forty-two midshipmen gave their lives in service to their country, and many others survived torpedo and aerial ... William N. Donnelly, IV (class of 2008) have both given their lives while serving their country in Afghanistan. ...
In Africa, traditional medicine is used for 80% of primary healthcare, and in developing nations as a whole over one-third of ... who are encouraged not only to pay their last penny but to be treated with something that shortens their lives. "At the same ... Traditional remedies, often closely resembling or forming the basis for alternative remedies, may comprise primary healthcare ... but is a usage newly coined by NCCIH in the primary source used for this article. "Biology-based" as coined by NCCIH may refer ...
The primary mechanical role of catenins is connecting cadherins to actin filaments, specifically in these adhesion junctions of ... "Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors". Cancer Res. 71 (7): 2718-27. ...
... placed renewed emphasis on those living in Khmer Rouge territory imitating the lives of the poorest peasants and in ... That year he began an education at a Roman Catholic primary school, the École Miche, with Meak paying the tuition fees. ... and Vorn Vet-also lived there. Pol Pot's wife, whose schizophrenia had worsened, was sent to live in a house in Boeung ... His family was of mixed Chinese and ethnic Khmer heritage, but did not speak Chinese and lived as though they were fully Khmer. ...
A narrow religion, a sectarian religion, an exclusive religion can live only for a limited time and a limited purpose. This is ... He believed that the primary requisite for national progress, national reform, is the free habit of free and healthy national ... In 1910, when, Aurobindo withdrew from political life and decided to live a life of renounciate, the Anushilan Samiti ... "Whether Rama of my imagination ever lived or not on this earth, the ancient ideal of Ramarajya is undoubtedly one of true ...
The primary flight feathers are replaced over a period of three months. Juvenile birds undergo a partial moult beginning about ... Magpies are normally sedentary and spend winters close to their nesting territories but birds living near the northern limit of ... The Asian subspecies P. p. bactriana has more extensive white on the primaries and a prominent white rump. ... Their body feathers start to appear after around 8 days and the primary wing feathers after 10 days. For several days ...
While living in Hall County, Texas, they also played at 'ranch dances' which were popular throughout west Texas. ... Wills' upbeat 1938 song Ida Red was Chuck Berry's primary inspiration for creating his first Rock and Roll hit - Maybellene. ... In addition, The Rolling Stones performed this song live in Austin, Texas at Zilker Park on their A Bigger Bang Tour, a shout- ... Having lived a lavish lifestyle in California, Wills moved back to Oklahoma City in 1949, then went back on the road to ...
Minimizing such occurrences as soon as possible is a primary mission of occupational and physical therapists employed within ... Other syndromes or conditions which can induce skeletal muscle atrophy are liver disease, and starvation. Muscle atrophy occurs ... liver failure, etc., and the wasting Dejerine-Sottas syndrome (HMSN Type III). Glucocorticoids, a class of medications used to ... when the patient has a primary injury such as an immobilized broken bone (set in a cast or immobilized in traction), for ...
Charlene and my friends wanted to be here today for this visit, Elvis touched our lives as well and the lives of so many people ... although toxicology reports strongly suggested that polypharmacy was the primary cause of death; "fourteen drugs were found in ... Buzz Cason, Living the Rock 'N' Roll Dream: The Adventures of Buzz Cason (2004), p.47. ... The Living Room contains a 15-foot-long (4.6 m) white sofa against the wall overlooking the front yard. To the left is a white ...
Wikipedia:In the news/Candidates/December 2006
Whether Johnson lives or dies could have an effect, for example, on US funding of family planning programs in Africa. That said ... even though the President has primary control of American foreign policy, a President whose party is a minority in both houses ... Not living in a serious cricketing country, it's hard for me to say whether this milestone merits ITN inclusion. The key ... God what a world we live in if people elsewhere think it's routine. Jooler 14:07, 15 December 2006 (UTC) *Of course it's common ...
The Big Bang (Doctor Who)
Haynes wanted the museum to feel "massive and eerie", and coached Blackwood to "live in the moment". The opening sequence ... Brangwyn Hall, which was used as the primary location for the museum. ...
Besides the native region it is also spoken by the Bengalis living in Tripura, southern Assam and the Bengali population in the ... Bengali words are virtually all trochaic; the primary stress falls on the initial syllable of the word, while secondary stress ... Bengali is the primary language spoken in Bangladesh and the second most widely spoken language in India. ... where the boldface represents primary and secondary stress. ...
Positron emission tomography
To conduct the scan, a short-lived radioactive tracer isotope is injected into the living subject (usually into blood ... Because of cost as well as the marginal utility of detecting cancer metastases in companion animals (the primary use of this ... Radionuclides used in PET scanning are typically isotopes with short half-lives such as carbon-11 (~20 min), nitrogen-13 (~ ... PET technology can be used to trace the biologic pathway of any compound in living humans (and many other species as well), ...
As a child he lived for some time in San Antonio, El Paso, and Mexico City. He was fluent in English. He attended the Military ... The story's proponents do not cite any primary source that confirms the telegram's existence. ...
Curved primary veins (3 subclasses). Pinnate (pinnatus). Single primary vein, the midrib, along which straight or arching ... meaning that they do not obtain food from other living things but instead create their own food by photosynthesis. They capture ... Primary veins with one or more points of secondary dichotomous branching beyond the primary divergence, either closely or more ... The additional terms marginal (primary veins reach the margin), and reticulate (primary veins do not reach the margin) are also ...
Both Mohenjo-Daro and Harappa are generally characterized as having "differentiated living quarters, flat-roofed brick houses, ... Cotton textiles and agricultural products were the primary trading objects. The Harappan merchants also had procurement ...
Special rules exist for those living in a nursing home and disabled children living at home. ... The insurance provides them with access to preventive and primary services which are used at a much higher rate than for the ... Similarly, if a child lives with someone other than a parent, he may still be eligible based on its individual status. ... More than half of people living with AIDS in the US are estimated to receive Medicaid payments. Two other programs that provide ...
Understanding Primary Liver Cancer
Memorial Sloan Kettering experts discuss advances in our understanding of primary liver cancer and new approaches to treating ... give an overview of primary liver cancer and the available treatment options. Dr. Abou-Alfa explains there is no one-size-fits- ... all solution for people with liver cancer, since treatment is driven by the type of cells that are affected and the location ...
Approach to Primary Liver Cancer | SpringerLink
Primary malignant liver tumor is the most frequent malignoma worldwide. This is due mainly to a high incidence in Asian and ... liver grafting was added. Many other approaches for therapy were also instituted. Thus, therapeutic access to a primary liver ... Lee NW, Wong I, Ong GB (1982) The surgical management of primary carcinoma of the liver. World J Surg 6: 66-75PubMedCrossRef ... Primary malignant liver tumor is the most frequent malignoma worldwide. This is due mainly to a high incidence in Asian and ...
Primary liver cancer - Macmillan Cancer Support
Find out what primary liver cancer is, its symptoms and how it is diagnosed. We also have information and about treatment and ... Liver cancer explained. Liver cancer explained. Liver surgeon Aamir Khan talks about primary liver cancer. He explains the ... Types of primary liver cancer Primary liver cancer is rare but increasing in the UK. The most common type is called ... Understanding primary liver cancer Related. Order or download our free booklet about primary liver cancer. It covers treatment ...
Opinion Journal Live: Tuesday Primaries
John Fund of WSJs Political Diary breaks down Tuesdays most interesting primary contests. Also, WSJ Columnist Mary Anastasia ... Opinion Journal Live: Tuesday Primaries. John Fund of WSJs Political Diary breaks down Tuesdays most interesting primary ... but Washington State Primary is different ... and are trying to import the California Over Primary the top two finishers ... A Home Built to Be a Live-In Museum and Expansive Library 2/21/2019 11:00AM 2/21/2019 After their house burned down, David ...
About primary liver cancer - Macmillan Cancer Support
Learn more about the liver, types of primary liver cancer and its symptoms. ... The most common type of primary liver cancer is known as HCC. ... Types of primary liver cancer * Symptoms of primary liver ... Liver cancer explained. Liver surgeon Aamir Khan talks about primary liver cancer. He explains the symptoms, how liver cancer ... Liver cancer explained. Liver surgeon Aamir Khan talks about primary liver cancer. He explains the symptoms, how liver cancer ...
FL Primary -- LIVE THREAD
... FreeRepublic , Waterloo Tuesday , FReepers Posted on 01/31/2012 10:01:12 AM PST by tomkat ... And once again Im painting during a primary, so if you bounce replies off my nick and dont hear back for a couple hours/ever ... http://www.washingtonpost.com/blogs/the-fix/post/five-counties-to-watch-in-the-florida-primary/2012/01/31/gIQAyuMIfQ_blog.html ...
Live results: 4 states hold primary elections - CNNPolitics
Our live coverage has ended. Go here or scroll through the post below to see how tonights primaries unfolded. ... Congressman Jim Renacci, who had the endorsement of President Trump, will win the GOP Primary in Ohio, setting up a fall race ... Don Blankenship, while working the room at his primary night party in Charleston, reflected on what he would do if he loses ... 4 states hold primary elections. Veronica Rocha, CNN. 10:58 p.m. ET, May 8, 2018 ...
Lilly's Cyramza Misses Primary Goal in Liver Cancer Study - WSJ
Eli Lilly said its Cyramza cancer drug failed to meet primary goals in a Phase III study of the drug as a secondary treatment ... Lillys Cyramza Misses Primary Goal in Liver Cancer Study. Study for Patients with Liver Cancer Doesnt Achieve Statistical ... cancer drug failed to meet primary goals in a Phase 3 study of the drug as a secondary treatment for patients with liver cancer ...
Pediatric Liver Trial Misses Primary Endpoint | Medpage Today
... levels in children and adolescents with nonalcoholic fatty liver disease (NAFLD), researchers say. ... Explain that a study of nonalcoholic fatty liver disease, the most common chronic liver disease in children, found that neither ... The primary outcome was sustained reduction in ALT, defined as 50% or less of the baseline level or 40 U/L or less at visits ... Primary Source. Journal of the American Medical Association. Source Reference: Lavine JE, et al "Effect of vitamin E or ...
LIVE UPDATES: Fourth Democratic presidential primary debate
Here are five things to watch in tonights Democratic presidential primary debate, which kicks off at 8 p.m. live from ... LIVE UPDATES: Fourth Democratic presidential… Share this:. *Click to share on Facebook (Opens in new window) ... So far, his health scare has garnered mixed reactions from voters in the first-in-the-nation primary state of New Hampshire: ... The stage is prepared where the CNN/New York Times will host the Democratic presidential primary debate at Otterbein University ...
Live from New York primary night | Newsday
Live from New York primary night. Milta Annunziata, left, and Donna Bendowski, both from Mattituck, cast their vote at ... About Us Subscribe Todays paper Email newsletters Newsday Live Newsday Charities Careers Manage my account Media Kit Brand 360 ... Filler: What winning NY means for Trump, ClintonThe New York presidential primaries this year turned out to be the political ... the last time there was a hotly contested presidential primary. In Nassau County, the board of elections counted 5,208 ballots ...
8 states vote in key primary elections: Live updates
8 states held primary elections yesterday. Heres how it went down. Kimberlee Weaver, left, an election worker for the ... Tuesday primaries: Voters went to the polls in California, Montana, Alabama, Iowa, Mississippi, New Jersey, New Mexico and ... Martha Roby will face a July runoff to save her seat after failing to top 50% in Tuesdays primary. Roby will face Bobby Bright ... Cox promised to grow the economy and cut the cost of living in California. He also vowed to "deliver results that matter with ...
MDCT of Primary liver malignancies | SpringerLink
Silverman PM, Kohan L, Ducic I, Javadi S, Meyer C, Sharma N, Cooper C, Zeman RK (1998) Imaging of the liver with helical CT: a ... Hollett MD, Jeffrey RB Jr, Nino-Murcia M, Jorgensen MJ, Harris DP (1995) Dual-phase helical CT of the liver: value of arterial ... Hänninen EL, Vogl TJ, Felfe R, Pegios W, Balzer J, Clauss W, Felix R (2000) Detection of focal liver lesions at biphasic spiral ... Awai K, Takada K, Onishi H, Hori S (2002) Aortic and hepatic enhancement and tumor-to-liver contrast: analysis of the effect of ...
Liver transplantation for primary sclerosing cholangitis
Liver transplantation is the only therapeutic option for patients with end stage liver disease resulting fr … ... is a chronic cholestatic liver disease of unknown aetiology that is progressive in most symptomatic patients, advancing toward ... Liver transplantation for primary sclerosing cholangitis Liver. 2000 Apr;20(2):97-103. doi: 10.1034/j.1600-0676.2000.020002097. ... Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology that is progressive in most ...
Radioembolization (TARE-Y90) for Liver Tumors (for Parents) - Primary Children's Hospital
Radioembolization is a procedure used to treat some kinds of liver tumors. A radioactive material works on the tumor, not the ... Radioembolization (ray-dee-oh-em-beh-lih-ZAY-shun) is a procedure used to treat some kinds of liver tumors. ... Because the radioactive beads are deep inside the liver, very little radiation leaves your childs body. Most of the ... Radioembolization goes through a blood vessel and right to the liver tumor. The radioactive material doesnt pass through ...
Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation
... Qusay A. Abdoh,1 Asma M ... 3Department of Liver and Small Bowel Transplantation and Hepatobiliary and Pancreatic Surgery, King Faisal Specialist Hospital ... J. A. Rodriguez, N. S. Becker, C. A. OMahony, J. A. Goss, and T. A. Aloia, "Long-term outcomes following liver transplantation ... K. G. Ishak, I. A. Sesterhenn, M. Z. D. Goodman, L. Rabin, and F. W. Stromeyer, "Epithelioid hemangioendothelioma of the liver ...
Hepatic Segrnentectomy on Primary Liver Cancer with Situs Inversus Totalis
Primary Liver Cancer: Surveillance, Diagnosis and Treatment : 9781280997099
Primary Liver Cancer | Vanderbilt-Ingram Cancer Center
Liver transplant. In a liver transplant, the entire liver is removed and replaced with a healthy donated liver. A liver ... Stages of Adult Primary Liver Cancer. Key Points. *After adult primary liver cancer has been diagnosed, tests are done to find ... Recurrent Adult Primary Liver Cancer. Recurrent adult primary liver cancer is cancer that has recurred (come back) after it has ... Adult primary liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver.. The liver is one ...
Does the New Hampshire Primary Always Predict a Winner? | Live Science
In recent elections, the primary has projected the eventual Republican nominee more times than not. ... The New Hampshire primary is always the first in the nation in every presidential election cycle. ... a win in the New Hampshire primary increases a candidates expected share of the total primary vote by a remarkable 26.8 ... Live Science is supported by its audience. When you purchase through links on our site, we may earn an affiliate commission. ...
Primary Biliary Cholangitis, An Issue of Clinics in Liver Disease, Volume 22-3 - 1st Edition
An Issue of Clinics in Liver Disease, Volume 22-3 - 1st Edition. Print Book & E-Book. ISBN 9780323613941, 9780323613958 ... Overlap Syndrome of Autoimmune Hepatitis and Primary Biliary Cholangitis Current Status of Liver Transplantation for Primary ... Primary Biliary Cholangitis, An Issue of Clinics in Liver Disease, Volume 22-3 1st Edition. ... Natural History of Primary Biliary Cholangitis in the Ursodeoxycholic Acid Era: Role of Scoring Systems ...
A trial comparing lenvatinib and sorafenib for primary liver cancer | Cancer Research UK
This trial is comparing lenvatinib with sorafenib for people with a type of primary liver cancer called hepatocellular ... A trial comparing lenvatinib and sorafenib for primary liver cancer. Please note - this trial is no longer recruiting patients ... If you have had radiotherapy or another treatment directly to liver, a scan must be able to show that your cancer has grown ... comparing an experimental drug called lenvatinib with an approved drug called sorafenib for people with a type of primary liver ...
Article - Primary hemangiopericytoma of the liver
A 59-year-old man presented to his primary care physician with a 10 lb weight loss and a slowly enlarging abdominal mass. ... Primary hemangiopericytoma of the liver. Findings. Large heterogeneous lesions of the liver are rarely resectable for cure. ... Primary hemangiopericytoma of the liver. By Timothy Oppermann, MD, Harry W. Sell, Jr., MD, FACS, Margaret A. Miller, MD, and ... Only 23 reported cases of primary liver hemangiopericytoma have been reported in the English literature.2 Both sexes in their ...
Primary Perception: Biocommunication with Plants, Living Foods, and Human Cells - Cleve Backster - Google Books
... observed electrical responses in plant life and other living organisms. All life forms have the capability of responding to one ... observed electrical responses in plant life and other living organisms. All life forms have the capability of responding to one ... Leukocytes Reacting Parapsychology Physicist Plant Reaction polygraph polygraph examiner polygraph school presentation primary ...
Primary Perception: Biocommunication with Plants, Living Foods, and Human Cells - Cleve Backster - Google Books
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Study of Pembrolizumab Following TACE in Primary Liver Carcinoma - Full Text View - ClinicalTrials.gov
Twenty-six to 32 evaluable participants with primary liver cancer (hepatocellular cancer; HCC) will be assessed. The primary ... Study of Pembrolizumab Following TACE in Primary Liver Carcinoma (PETAL). The safety and scientific validity of this study is ... Primary Liver Carcinoma Drug: Pembrolizumab Combination Product: Trans-arterial chemoembolization Phase 1 Phase 2 ... Liver Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Digestive System Diseases. Liver Diseases. Pembrolizumab. ...
Efficacy of liver transplantation in patients with primary biliary cirrhosis
Because of the marked improvement in survival after liver transplantation since 1981, random assignment of patients to a ... No controlled trials have been performed to assess the efficacy of liver transplantation. ... Efficacy of liver transplantation in patients with primary biliary cirrhosis N Engl J Med. 1989 Jun 29;320(26):1709-13. doi: ... We conclude that liver transplantation is an efficacious treatment in patients with advanced primary biliary cirrhosis. ...
Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America - 1st Edition
Purchase Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America - 1st Edition. Print ... Staging of Biliary Tract and Primary Liver Tumors; Intra-arterial Therapies: Primary Liver Tumors; Radiotherapy: Primary Liver ... Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America 1st Edition. ... Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America ...
Trends in incidence of primary liver cancer subtypes
... Background. Primary liver cancer incidence is increasing in England. The ... Intrahepatic bile duct carcinoma is the second most common primary liver cancer subtype and the causes of this cancer are ... This subtype made up 55.3% of male and 28.2% of female primary liver cancer diagnoses for the period 1998-2007. Age- ... This subtype made up 30.6% of male and 55.5% of female primary liver cancer diagnoses for the period 1998-2007. Age- ...
laparoscopic Liver Resection for Localized Primary Intrahepatic Bile Duct Dilatation - SAGES Abstract Archives
laparoscopic Liver Resection for Localized Primary Intrahepatic Bile Duct Dilatation. LAPAROSCOPIC LIVER RESECTION FOR ... Free SAGES Webinar: Lessons from COVID on Living and Thriving as Surgeons. SAGES recognizes that the COVID-19 pandemic has had ... Laparoscopy has gained large interest in liver surgery. It also allows a safe and efficient exploration of the common bile duct ... Objective of the study: Primary intrahepatic bile duct dilatation (IHBD) may present as a localized form, in which resection of ...
Sclerosing cholangitisTumorsHepaticMetastasesTumorCancerCancersResectionBiliary CholangitisBiopsyDiagnosisDiseaseCarcinomaHepatitisStrains causing primary liverMetastasisMalignanciesTissueCirrhoticAutoimmuneBile ductsTransplantMalignant liverFibrosisCholangiocarcinomaAbscessTreatmentNAFLDHuman liverTissuesTransplantation for primaryIntestinesProgressionDonorRisk factorsSymptomaticLesionsUrsodeoxycholic acidNeoplasmsDiseasesNecessitating liver transplantationComplicationsHumansHepatocytesOutcomeStudy
- Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology that is progressive in most symptomatic patients, advancing toward cirrhosis and liver failure. (nih.gov)
- Primary sclerosing cholangitis greatly increases risk of cholangiocarcinoma (1) . (merckmanuals.com)
- Cancer surveillance in patients with primary sclerosing cholangitis. (merckmanuals.com)
- Primary sclerosing cholangitis is inflammation with progressive scarring and narrowing of the bile ducts in and outside the liver. (merckmanuals.com)
- In primary sclerosing cholangitis, bile ducts become inflamed, which can lead to scarring of the bile ducts and liver tissue that progresses, eventually becoming severe (cirrhosis). (merckmanuals.com)
- Primary sclerosing cholangitis most often affects young men and is diagnosed at an average age of 40. (merckmanuals.com)
- Gallstones and bile duct stones develop in about three fourths of people with primary sclerosing cholangitis. (merckmanuals.com)
- Cancer of the bile ducts ( cholangiocarcinoma ) develops in 10 to 15% of people with primary sclerosing cholangitis. (merckmanuals.com)
- Usually, primary sclerosing cholangitis worsens gradually. (merckmanuals.com)
- When four patients with primary sclerosing cholangitis (PSC) were analyzed, they also differed from those with PBC. (cun.es)
- Dr. Abou-Alfa explains there is no one-size-fits-all solution for people with liver cancer, since treatment is driven by the type of cells that are affected and the location and size of tumors. (mskcc.org)
- such tumors were generally diagnosed very late and liver resection therapy was uncommon, particularly in cirrhotic but also in non-cirrhotic patients. (springer.com)
- Adson MA, Weiland LH (1981) Resection of primary solid hepatic tumors. (springer.com)
- Foster JH, Berman MM (1977) Solid liver tumors. (springer.com)
- Radioembolization (ray-dee-oh-em-beh-lih-ZAY-shun) is a procedure used to treat some kinds of liver tumors . (kidshealth.org)
- These tumors are derived from mesenchymal cells, can be benign or malignant, and occur more commonly in the lower extremities, but they have been described in the liver, pelvis and retroperitoneum. (appliedradiology.com)
- Although imaging features may suggest the diagnosis of a primary hemangiopericytoma of the liver, other benign or malignant hepatic tumors such as sarcoma, leiomyoma and inflammatory pseudotumor of the liver may have similar features. (appliedradiology.com)
- This issue of Surgical Oncology Clinics of North America is devoted to 'Biliary Tract and Primary Liver Tumors' and is edited by Timothy Pawlik, MD, of the Johns Hopkins Hospital in Baltimore. (elsevier.com)
- and Palliation: Treating Patients with Inoperable Biliary Tract and Primary Liver Tumors. (elsevier.com)
- Since we are looking for the highest dose of the study agent that can be administered safely without severe or unmanageable side effects in participants that have liver tumors, not everyone who participates in this research study will receive the same dose of the study drug. (clinicaltrials.gov)
- The incidence of primary and metastatic liver tumors is rising and the therapeutic armamentarium for these tumors is expanding at a rapid pace. (springer.com)
- As surgery remains the primary treatment modality for these tumors, this book provides a comprehensive, state-of-the art review of the current state of surgical, locoregional and systemic therapy options for malignant liver tumors. (springer.com)
- It serves as a valuable resource not only for surgeons, oncologists, and clinicians but also for researchers with an interest in malignant liver tumors. (springer.com)
- Chapters focus on the therapeutic approach to primary and metastatic tumors, providing an up-to-date review on surgical approach, new imaging techniques, patient selection, and technical considerations for liver resection and transplantation. (springer.com)
- ABSTRACT: Primary and metastatic liver tumors continue to be a significant health problem in the United States. (cancernetwork.com)
- Other rare primary tumors also are seen in the liver. (cancernetwork.com)
- Intrahepatic cholangiocarcinomas represent less than 0.5% of liver tumors. (cancernetwork.com)
- Patients with liver metastases from other solid tumors also are candidates for resection. (cancernetwork.com)
- Liver metastases from endocrine tumors rarely present with localized disease that can be completely resected, but if localized, surgical resection is the treatment of choice. (cancernetwork.com)
- Nineteen patients (48.7%) underwent radical liver resection, and 15 patients (38.5%) received palliative resection to remove the tumors. (sages.org)
- T-VEC will be injected directly into liver tumors, and pembrolizumab will be given intravenously (by vein). (mskcc.org)
- Is Antibiotic Prophylaxis for Percutaneous Radiofrequency Ablation (RFA) of Primary Liver Tumors Necessary? (osti.gov)
- PurposeThe purpose of this study was to evaluate need for antibiotic prophylaxis for radiofrequency ablation (RFA) of liver tumors in patients with no significant co-existing risk factors for infection.Materials and MethodsFrom January 2004 to September 2013, 83 patients underwent 123 percutaneous RFA procedures for total of 152 hepatocellular carcinoma (HCC) lesions. (osti.gov)
- This study revealed that ARL4C is highly expressed in primary hepatocellular carcinoma (HCC) tumors and colorectal cancer liver metastases, and that ARL4C expression is associated with poor prognosis for these cancers. (aacrjournals.org)
- The liver is an organ that develops primary and metastatic tumors. (aacrjournals.org)
- Our paper offers a critical interdisciplinary overview of the treatments in both primary and secondary liver tumors, including from a cost-effective point of view. (termedia.pl)
- Here we extend this culture system to the propagation of primary liver cancer (PLC) organoids from three of the most common PLC subtypes: hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and combined HCC/CC (CHC) tumors. (eur.nl)
- Metastatic tumors in the liver are 20 times more common than primary tumors. (wikipedia.org)
- Wu MC (1978) Resection of primary hepatic carcinoma during a period of 18 years. (springer.com)
- Hollett MD, Jeffrey RB Jr, Nino-Murcia M, Jorgensen MJ, Harris DP (1995) Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (≦1.5 cm) malignant hepatic neoplasms. (springer.com)
- Frederick MG, McElenay BL, Singer A, Park KS, Paulson EK, McGee SG, Nelson RC (1996) Timing of parenchymal enhancement on dual-phase dynamic helical CT of the liver: How long does the hepatic phase predominate? (springer.com)
- Awai K, Takada K, Onishi H, Hori S (2002) Aortic and hepatic enhancement and tumor-to-liver contrast: analysis of the effect of different concentrations of contrast material at multidetector-row helical CT. (springer.com)
- Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation," Canadian Journal of Gastroenterology and Hepatology , vol. 2016, Article ID 6135297, 3 pages, 2016. (hindawi.com)
- Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy," Cancer , vol. 107, no. 9, pp. 2108-2121, 2006. (hindawi.com)
- The place of liver transplantation in the treatment of hepatic epitheloid hemangioendothelioma: report of the European liver transplant registry," Annals of Surgery , vol. 246, no. 6, pp. 949-957, 2007. (hindawi.com)
- An 81-year-old man presented with recurrent fevers and a computed tomography (CT) scan revealing a large liver lesion thought to be a hepatic abscess. (healio.com)
- Chemosaturation via percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic liver cancer ('hepatic chemosaturation') should only be performed within the context of research, which may take the form of observational studies. (nice.org.uk)
- Hepatic resection or, in selected cases, transplantation are the only curative therapies for patients with resectable disease confined to the liver. (cancernetwork.com)
- The presence of compromised liver function, thrombocytopenia, and coagulopathy with increased intraoperative blood loss can lead to postoperative hepatic decompensation and failure. (cancernetwork.com)
- Patients with Wilms' tumor are excellent candidates for resection of hepatic metastases, as are those with a solitary liver metastasis from renal cell carcinoma. (cancernetwork.com)
- The aim of this study is to clarify the clinical features, sur-gical treatment, and prognosis of patients with primary hepatic CS and SC. (sages.org)
- Methods: Between January 1996 and August 2012, 7 and 32 patients were histologi-cally diagnosed as primary hepatic CS and SC, respectively. (sages.org)
- Conclusion: Both primary hepatic CS and SC are highly aggressive malignancies with extremely poor prognosis. (sages.org)
- Ishikawa K, Kosaka K (1973) Results of hepatic resection for primary liver cancer. (springer.com)
- We have previously reported decreased hepatic levels of AE2 messenger RNA in patients with primary biliary cirrhosis (PBC), a cholestatic condition frequently associated with pluriglandular exocrine failure. (cun.es)
- Of these 53 patients, 26 had diabetes mellitus, 25 were otherwise healthy before development of the abscess, one patient had nephrotic syndrome, and one patient displayed hepatic failure associated with advanced liver cirrhosis. (rupress.org)
- Hepatic stellate cells (HSCs) are one of the major interstitial cell types present in the liver tumor microenvironment, and can promote the proliferation, migration and invasion of PLC cells. (spandidos-publications.com)
- The basis for unresectability being the presence of extra-hepatic disease, limited liver synthetic function, co-morbidity (ASA>3), bilobar disease and anatomical location. (knowcancer.com)
- Effects of Ursodeoxycholic Acid on Hepatic Inflammation and Histological Stage in Patients with Primary Biliary Cirrhosis. (ebscohost.com)
- Objective: To analyse the relationship between Hepatic Steatosis, also known as Non-Alcoholic Fatty Liver disease (NAFLD) in patients with metabolic syndrome criteria and cardiovascular risk factors. (alliedacademies.org)
- The mechanisms leading to the development of hepatic steatosis are partially known: it is accepted that the factors that determine the appearance of the steatosis are insulin resistance, increased flow of fatty acids to the hepatocytes, less elimination of triglycerides in the liver and less fatty acid oxidation [ 4 - 7 ]. (alliedacademies.org)
- The liver is a common site for metastatic disease because of its rich, dual blood supply (the liver receives blood via the hepatic artery and portal vein). (wikipedia.org)
- Due to the complexity of treating HCC and liver metastases, collaboration between medical oncologists, surgeons and radiation therapists is needed. (cirse.org)
- It is expected that as many as 25% of patients with colorectal cancer will have liver metastases at presentation and 50% will have liver metastases develop metachronously. (cancernetwork.com)
- In this study, researchers are assessing the safety and effectiveness of combining talimogene laherparepvec (T-VEC) with pembrolizumab immunotherapy in patients with inoperable primary liver cancer or liver metastases. (mskcc.org)
- Patients must have hepatocellular carcinoma or liver metastases from another cancer. (mskcc.org)
- Patients had ninefold higher odds of radiologic progression of their liver metastases at 3 months if they had a primary tumor resection as compared with neoadjuvant chemotherapy. (mdedge.com)
- A retrospective cohort study of 114 patients with colorectal cancer and isolated synchronous liver metastases. (mdedge.com)
- PHOENIX - The standard sequential approach to treatment of patients with isolated synchronous liver metastases of colorectal cancer, entailing up-front removal of the primary tumor, is associated with growth of the metastases, according to results from a retrospective cohort study. (mdedge.com)
- A team led by Dr. Alistair Slesser, a surgical registrar at the Royal Marsden Hospital in London, studied 114 patients with colorectal cancer who had synchronous liver metastases, meaning ones identified within a year of the cancer diagnosis, and no other metastases. (mdedge.com)
- Results showed that patients whose initial treatment was resection of the colorectal primary tumor had ninefold higher odds of progression of their liver metastases at 3 months, compared with patients whose initial treatment was chemotherapy, he reported at the annual meeting of the American Society of Colon and Rectal Surgeons. (mdedge.com)
- Although liver metastases showed regression during 3-6 months of treatment in both groups, the rate was somewhat slower in the primary tumor resection group. (mdedge.com)
- When patients have lesions which are suspicious for liver metastases, we would recommend that these patients [be] thoroughly investigated, and if metastatic disease is confirmed, then again, we would recommend that they have chemotherapy prior to any subsequent intervention," he added. (mdedge.com)
- The mechanism leading to growth of liver metastases after primary tumor resection is unknown, according to Dr. Slesser. (mdedge.com)
- This study aimed to provide an independent characterization of the transcriptional landscape of breast cancer metastases with the specific objective to identify liver metastasis-selective genes of prognostic importance following primary tumor diagnosis. (aacrjournals.org)
- However, liver metastases displayed unique transcriptional fingerprints, characterized by downregulation of extracellular matrix (i.e., stromal) genes. (aacrjournals.org)
- Main sites of metastases for some common cancer types, showing liver as the target for many types. (wikipedia.org)
- Younger patients with metastases from colorectal cancer confined to one lobe of the liver and up to 4 in number may be treated by partial hepatectomy. (wikipedia.org)
- A careful search for other metastases is required, including local recurrence of the original primary tumor (e.g., via colonoscopy) and dissemination elsewhere (e.g., via CT of the thorax). (wikipedia.org)
- Primary malignant liver tumor is the most frequent malignoma worldwide. (springer.com)
- Kopp AF, Heuschmid M, Claussen CD (2002) Multidetector helical CT of the liver for tumor detection and characterization. (springer.com)
- Radioembolization goes through a blood vessel and right to the liver tumor. (kidshealth.org)
- Solitary fibrous tumor of the liver. (appliedradiology.com)
- Metastatic neoplasms are much more common and represent the most common malignant tumor of the liver. (cancernetwork.com)
- Three conditions preclude liver resection: an unacceptable risk based on the degree of cirrhosis, evidence of extrahepatic disease, and tumor spread within the liver that prevents the attainment of clear surgical margins. (cancernetwork.com)
- Each case had at least four 1.5-mm cores of tumor and four 1.5-mm cores of nonneoplastic liver. (aacrjournals.org)
- ARL4C ASO accumulated in cancer cells more efficiently than the surrounding normal cells in the liver and decreased ARL4C expression in the tumor. (aacrjournals.org)
- PM consists of total protein from primary tumor and corresponding metastatic tumor. (novusbio.com)
- Our findings suggest that an up-front primary tumor resection is actually an adverse prognostic factor. (mdedge.com)
- Indeed, our results have demonstrated that up-front primary tumor resection seemed to negate the effects of the adjuvant therapy on the treatment of the liver metastasis," Dr. Slesser commented. (mdedge.com)
- We would recommend that patients who have limited metastatic disease, instead of having an up-front primary tumor resection perhaps [they should] be treated with neoadjuvant chemotherapy first. (mdedge.com)
- Or perhaps another surgical approach, like a simultaneous resection, should be considered to negate the adverse effects of a primary tumor resection on the metastatic disease," he said. (mdedge.com)
- The other reason is that perhaps when a patient has an up-front primary tumor resection, there is a delay in getting chemotherapy, and that can cause the progression that we see. (mdedge.com)
- Attendee Dr. David Shibata, of the Moffitt Cancer Center in Tampa, commented, "I think a critical question is that you have done a primary tumor resection and the liver tumor has tended to grow, which is not entirely surprising, but then in those cases, how many became unresectable from a liver standpoint? (mdedge.com)
- There was a positive tumor marker alfa-fetoprotein (0.5 μg/L). The histology of the liver biopsy performed with ultrasound control revealed that it was diffuse large B cell lymphoma. (scirp.org)
- Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. (eur.nl)
- A liver metastasis is a malignant tumor in the liver that has spread from another organ affected by cancer. (wikipedia.org)
- In 50% of all cases the primary tumor is of the gastrointestinal tract, other common sites include the breast, ovaries, bronchus and kidney. (wikipedia.org)
- Tumor emboli entering the sinusoids through the liver blood supply appear to be physically obstructed by the Kupffer cells, but if tumor emboli are larger, they tend to become lodged in the portal venous branches. (wikipedia.org)
- Cross section of a human liver, taken at autopsy examination, showing multiple large pale tumor deposits. (wikipedia.org)
- The tumor is an adenocarcinoma derived from a primary lesion in the body of the pancreas. (wikipedia.org)
- In this portion of a Memorial Sloan Kettering CancerSmart video series moderated by CBS's Max Gomez, our experts, including gastroenterologist and hepatologist Maya Gambarin-Gelwan , medical oncologist Ghassan Abou-Alfa , interventional radiologist Karen Brown, and surgeon William Jarnagin , give an overview of primary liver cancer and the available treatment options . (mskcc.org)
- Almersjü O, Bengmark S, Hafstrüm L (1976) Liver resection for cancer. (springer.com)
- Information and support for people affected by primary liver cancer. (macmillan.org.uk)
- Liver surgeon Aamir Khan talks about primary liver cancer. (macmillan.org.uk)
- Primary liver cancer is rare but increasing in the UK. (macmillan.org.uk)
- Order or download our free booklet about primary liver cancer. (macmillan.org.uk)
- A place for people affected by liver cancer to support one another, ask questions, and share their experiences. (macmillan.org.uk)
- Good Morning My father in law has terninal liver cancer HCC with Chirrosis and Ascities. (macmillan.org.uk)
- DUFFYLASS2017 joined the group Liver cancer . (macmillan.org.uk)
- Find out more about the liver and different kinds of liver cancer. (macmillan.org.uk)
- In the early stages of primary liver cancer, there are often no symptoms. (macmillan.org.uk)
- We do not know the exact cause of primary liver cancer. (macmillan.org.uk)
- Eli Lilly & Co. said its Cyramza cancer drug failed to meet primary goals in a Phase 3 study of the drug as a secondary treatment for patients with liver cancer. (wsj.com)
- Adult primary liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver. (vicc.org)
- There are two types of adult primary liver cancer. (vicc.org)
- The most common type of adult primary liver cancer is hepatocellular carcinoma. (vicc.org)
- This type of liver cancer is the third leading cause of cancer-related deaths worldwide. (vicc.org)
- This summary is about the treatment of primary liver cancer ( cancer that begins in the liver). (vicc.org)
- Treatment of cancer that begins in other parts of the body and spreads to the liver is not covered in this summary. (vicc.org)
- Primary liver cancer can occur in both adults and children. (vicc.org)
- See the PDQ summary on Childhood Liver Cancer Treatment for more information. (vicc.org)
- Having hepatitis or cirrhosis can affect the risk of adult primary liver cancer. (vicc.org)
- Signs and symptoms of adult primary liver cancer include a lump or pain on the right side. (vicc.org)
- These and other signs and symptoms may be caused by adult primary liver cancer or by other conditions. (vicc.org)
- Tests that examine the liver and the blood are used to detect (find) and diagnose adult primary liver cancer. (vicc.org)
- An increased level of alpha-fetoprotein (AFP) in the blood may be a sign of liver cancer. (vicc.org)
- Sometimes the AFP level is normal even when there is liver cancer. (vicc.org)
- This trial is comparing an experimental drug called lenvatinib with an approved drug called sorafenib for people with a type of primary liver cancer called hepatocellular carcinoma. (cancerresearchuk.org)
- Primary liver cancer incidence is increasing in England. (ncin.org.uk)
- The most common subtypes are hepatocellular carcinoma (ICD10 C22.0, cancer occurring in the liver cells), and intrahepatic bile duct carcinoma (ICD10 C22.1, cancer originating in the sections of bile ducts that are inside the liver). (ncin.org.uk)
- Hepatocellular carcinoma makes up more than 85% of primary liver cancer diagnoses worldwide and occurs mainly in developing regions. (ncin.org.uk)
- Intrahepatic bile duct carcinoma is the second most common primary liver cancer subtype and the causes of this cancer are unclear. (ncin.org.uk)
- There were 23,269 patients diagnosed with primary liver cancer between 1998 and 2007 in England. (ncin.org.uk)
- This subtype made up 55.3% of male and 28.2% of female primary liver cancer diagnoses for the period 1998-2007. (ncin.org.uk)
- This subtype made up 30.6% of male and 55.5% of female primary liver cancer diagnoses for the period 1998-2007. (ncin.org.uk)
- Data on patients diagnosed with primary liver cancer (International Classification of Diseases (ICD10) C22.0-C22.9) in England between 1998 and 2007 were extracted from the National Cancer Data Repository. (ncin.org.uk)
- The dataset consisted of 23,269 patients with primary liver cancer (Table 1). (ncin.org.uk)
- Generally it is reported that hepatocellular carcinoma is the most common primary liver cancer subtype. (ncin.org.uk)
- We are also looking to see how well the body tolerates the study agent, how the agent is absorbed by the liver cancers, how quickly the agent is eliminated from the body, and what kind of anti-cancer effect it may have. (clinicaltrials.gov)
- Liver cancer includes two major types: hepatocellular carcinoma (HCC) and intrahepatic bile duct cancer. (cigna.com)
- Aflatoxin B1 has also been implicated as a cofactor in the etiology of primary liver cancer in carriers of HBV because it increases the neoplastic risk threefold. (cigna.com)
- Refer to the PDQ summary on Liver (Hepatocellular) Cancer Prevention for more information. (cigna.com)
- Virginia Mason's Liver Center of Excellence in the Digestive Disease Institute is dedicated to progressive and innovative management of liver disorders, advanced liver disease such as cirrhosis and liver cancer. (virginiamason.org)
- Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database. (nih.gov)
- Metabolic syndrome is also a risk factor for primary liver cancer in patients younger than 65 years of age? (nih.gov)
- The incidence of primary colorectal cancer, the most common cancer metastasizing to the liver, is estimated to be 138,200, with 55,300 deaths . (cancernetwork.com)
- Surgical resection also is the only potential curative treatment for metastatic cancer to the liver. (cancernetwork.com)
- Without surgery, the median survival of patients with metastatic colorectal cancer confined to the liver is measured in months, with the majority of patients dying within a year ( Table 1 ) [4-11]. (cancernetwork.com)
- Preventing primary liver cancer: how well are we faring towards a national hepatitis B strategy? (mja.com.au)
- W orldwide, primary liver cancer is the fifth most common cancer and the third most common cause of cancer-related death. (mja.com.au)
- in New South Wales, primary liver cancer incidence rates have been rising faster than incidence rates of any other internal cancer. (mja.com.au)
- The Cancer Council NSW's report Cancer incidence in New South Wales migrants 1991 to 2001 stated that, although immigrants had an overall incidence of cancer commensurate with their proportional representation in the NSW population (24.5%), their rate of primary liver cancer was substantially higher, with 46% of all diagnoses occurring in overseas-born people. (mja.com.au)
- 3 Standardised incidence ratios for primary liver cancer in men born in Vietnam, Hong Kong and Macau, Korea, Indonesia and China, and in women born in Vietnam and China, were at least six times those in Australian-born people 3 ( Box 1 ). (mja.com.au)
- In NSW, liver cancer shows geographic clustering, with rates in western Sydney far exceeding the NSW average (12.1 versus 4.8 cases per 100 000 population). (mja.com.au)
- Over 80% of primary liver cancer worldwide is attributable to the effects of chronic infection with hepatitis B or C virus (HBV or HCV). (mja.com.au)
- 5 People with chronic HBV or HCV infection have a 20-fold to 200-fold greater risk than those not infected of developing hepatocellular carcinoma (HCC) 6 , 7 (the most common form of primary liver cancer). (mja.com.au)
- The high incidence of primary liver cancer in East Asia and South-East Asia is largely attributable to the high prevalence of chronic HBV infection in these regions. (mja.com.au)
- Between 15% and 40% of people with chronic HBV infection develop liver-related morbidity, including cirrhosis, liver failure and liver cancer. (mja.com.au)
- in people with cirrhosis, the annual incidence of primary liver cancer ranges from 2%-3% in Western countries to 6%-11% in Asian populations. (mja.com.au)
- The recent demonstration of a close correlation between HBV replication and the risk of disease progression and liver cancer, 12 - 14 coupled with data suggesting that effective suppression of viral replication may reduce the risk of primary liver cancer, 12 - 15 represents a paradigm shift in cancer prevention strategies. (mja.com.au)
- 10 000 copies/mL) is a strong predictor of liver cancer risk, independent of any other markers of activity, such as HBeAg, alanine aminotransferase and cirrhosis. (mja.com.au)
- Primary liver cancer is a cancer that starts in the liver rather than a cancer that starts elsewhere and spreads to the liver. (annals.org)
- Most types of primary liver cancer arise from abnormal cells in the liver (hepatocellular carcinoma). (annals.org)
- The exact cause of the abnormal cells is unclear, but most people with primary liver cancer also have liver scarring (cirrhosis) and some have had chronic viral infections of the liver (hepatitis B or C) for 20 to 40 years or heavy alcohol drinking for several years. (annals.org)
- The number of people in the United States with a diagnosis of primary liver cancer started increasing in the early 1980s. (annals.org)
- If these infections were related to liver cancer, cancer rates might continue to increase for many years, particularly in groups that were exposed to hepatitis C virus in the 1960s and 1970s. (annals.org)
- To see whether rates of liver cancer (hepatocellular carcinoma) have continued to increase in the United States. (annals.org)
- People who received a diagnosis of liver cancer between 1975 and 1998. (annals.org)
- The researchers looked at whether numbers of new cases of liver cancer increased from the 1970s to the 1990s and whether rates of any increases were leveling off. (annals.org)
- Incidence rates of liver cancer doubled from 1975 to 1998. (annals.org)
- Because no blood tests for hepatitis C virus infections were available, no direct linkages between these infections and liver cancer could be made. (annals.org)
- The number of cases of liver cancer in the United States is still increasing rapidly, especially among white men 45 to 54 years of age. (annals.org)
- Primary care physicians play a critical role in the treatment and survival of pancreatic cancer patients. (ucsfhealth.org)
- In addition, subcutaneous injection of ARL4C ASO was effective in reducing the growth of primary HCC and metastatic colorectal cancer in the liver of immunodeficient mice. (aacrjournals.org)
- Primary care patients with a suspected head and neck cancer are referred through the urgent suspicion of cancer referral pathway. (bioportfolio.com)
- Since 1965, the Liver Cancer Study Group of Japan [1-6] has been carrying out analyses of patients with primary liver cancer in Japan every 2 or 3 years. (springer.com)
- Ishikawa K (1976) Follow-up study of patients with primary liver cancer: Report 3. (springer.com)
- Okuda K and the Liver Cancer Study Group of Japan (1980) Primary liver cancer. (springer.com)
- The Liver Cancer Study Group of Japan (1984) Primary liver cancer in Japan. (springer.com)
- Primary liver cancer in Japan (sixth report). (springer.com)
- Kamiyama Y., Tobe T. (1987) Treatment of Primary Liver Cancer in Japan. (springer.com)
- Primary liver cancer is usually hepatocellular carcinoma . (merckmanuals.com)
- The first manifestations of liver cancer are usually nonspecific, delaying the diagnosis. (merckmanuals.com)
- Cirrhosis, liver failure, and sometimes bile duct cancer develop. (merckmanuals.com)
- As a co‑receptor for a variety of cytokines, neuropilin‑1 (NRP‑1) is detectable in primary liver cancer (PLC) cells. (spandidos-publications.com)
- With increasing numbers of people surviving their cancer diagnosis, cancer follow up in primary care is likely to start to resemble that of other chronic diseases like COPD or Diabetes. (eventbrite.co.uk)
- PLC-derived organoids are amenable for biomarker identification and drug-screening testing and led to the identification of the ERK inhibitor SCH772984 as a potential therapeutic agent for primary liver cancer. (eur.nl)
- We thus demonstrate the wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease. (eur.nl)
- Finally, the prognostic relevance of the liver metastasis-selective genes in primary breast cancer was tested. (aacrjournals.org)
- Hemoglobin decrease Liver function test: ALP elevated, bilirubin elevated, albumin decrease Carcinoembryonic antigen for colorectal secondaries Ultrasound scan CT scan Biopsy under ultrasound control Micrograph of a liver core needle biopsy showing metastatic cancer. (wikipedia.org)
- In 1995, the estimated incidence of primary liver and biliary cancers was 18,500 cases in the United States, with 7,800 estimated deaths from these cancers. (cancernetwork.com)
- These results suggest that ARL4C ASO represents a novel targeted nucleic acid medicine for the treatment of primary and metastatic liver cancers. (aacrjournals.org)
- Other primary liver cancers are uncommon or rare. (merckmanuals.com)
- Although rare, hepatoblastoma is one of the most common primary liver cancers in infants, particularly those with a family history of familial adenomatous polyposis . (merckmanuals.com)
- Although surgical ablation represents the gold standard, in the past decade there was an expansion in the use of non-surgical ablative techniques: radiofrequency, microwave, laser, cryoablation, irreversible electroporation, and interventional radiotherapy (brachytherapy) in primary as well as secondary liver cancers. (termedia.pl)
- Be ineligible for surgical resection or liver transplantation. (clinicaltrials.gov)
- Objective of the study: Primary intrahepatic bile duct dilatation (IHBD) may present as a localized form, in which resection of the affected liver can prevent immediate and late complications. (sages.org)
- We present here our results concerning the feasibility and safety of anatomical laparoscopic liver resection for localized IHBD. (sages.org)
- Resection or liver transplantation may prolong survival. (merckmanuals.com)
- Treatment is liver resection. (merckmanuals.com)
- This protocol is for a prospective multi-centre clinical trial of the use of RFA aspiration in the treatment of patients with primary/secondary malignancies of the liver, which are not suitable for formal liver resection. (knowcancer.com)
- Antimitochondrial Antibody-Negative Primary Biliary Cholangitis: Is It Really the Same Disease? (elsevier.com)
- Primary biliary cholangitis (PBC) is a progressive autoimmune disease of the liver. (virginiamason.org)
- The disorder resembles primary biliary cholangitis except that it affects the bile ducts outside the liver as well as those in the liver. (merckmanuals.com)
- This event is for patients/caregivers and healthcare professionals looking to learn more about Primary Biliary Cholangitis (PBC). (liverfoundation.org)
- Primary biliary cirrhosis (also called primary biliary cholangitis) is a chronic disease that slowly damages and destroys the bile ducts. (columbiasurgery.org)
- Background: The importance of primary biliary cholangitis as an indication for liver transplantation has probably been influenced by the introduction of therapies, and changes in selection criteria and disease epidemiology. (eur.nl)
- Aims: To assess the time trends in liver transplantation for primary biliary cholangitis and to evaluate the characteristics of the patient population during the past three decades. (eur.nl)
- Results: We included 112 874 patients, of whom 6029 (5.3%) had primary biliary cholangitis. (eur.nl)
- After an initial increase in the first decade, the annual number of liver transplantation for primary biliary cholangitis remained stable at around 200. (eur.nl)
- Primary biliary cholangitis was the only indication showing a consistent proportional decrease throughout all decades. (eur.nl)
- Conclusions: We have found a proportional decrease in primary biliary cholangitis as indication for liver transplantation. (eur.nl)
- Your provider may recommend removing a small piece of liver tissue through a tiny incision on the abdomen or neck, a procedure called a liver biopsy, to determine if and to what extent PBC is present. (virginiamason.org)
- Using a monoclonal antibody against an AE2 peptide, immunohistochemistry was performed on liver biopsy specimens from subjects with normal liver (n = 7), patients with PBC (n = 13), and patients with cirrhosis or cholestasis other than PBC (n = 17 and 11, respectively). (cun.es)
- AE2 immunoreactivity was observed in normal livers, as previously reported, and in many pathological liver biopsy specimens, being mainly restricted to canaliculi and the luminal membrane of terminal and interlobular bile ducts. (cun.es)
- To assess the efficacy of liver transplantation in patients with primary biliary cirrhosis, we compared survival in 161 patients with this diagnosis who had undergone a liver transplantation with survival in patients with the same diagnosis who had been treated conservatively. (nih.gov)
- For patients with liver lesions larger than 1 cm who are at risk for HCC, a diagnosis can be considered. (unchealthcare.org)
- In patients with cirrhosis, liver disease, or other risk factors for HCC, and with lesions greater than 1 cm, triple-phase, contrast-enhanced studies (dynamic computed tomography [CT] or magnetic resonance imaging [MRI]) can be used to establish a diagnosis of HCC. (unchealthcare.org)
- The diagnosis of primary liver abscess was confirmed by sonography-guided aspiration or surgical drainage in 53 of these 101 patients. (rupress.org)
- These include whether or not symptoms are present at diagnosis, how well their liver is functioning, and how well they adhere to their treatment regimen. (columbiasurgery.org)
- After a complicated diagnostic and therapeutic process, the diagnosis of primary angiosarcoma of the small intestine with metastasis to the liver was made by pathological and immunohistochemical examinations. (biomedsearch.com)
- For the 405 patients with a liver disease diagnosis, 33.6, 53.8, and 12.6 percent were referred by GP, nurse-led case finding, and the AUDIT mail-out, respectively. (physiciansweekly.com)
- i.e. early diagnosis [ 10 ] and collaborative management [ 11 ] in primary care. (ersjournals.com)
- definitive diagnosis of liver cirrhosis. (bmj.com)
- Our experts also discuss risk factors such as infection with hepatitis B or C, alcoholic cirrhosis (scarring), and fatty liver disease. (mskcc.org)
- Explain that a study of nonalcoholic fatty liver disease, the most common chronic liver disease in children, found that neither vitamin E nor metformin produced a significant decrease in alanine aminotransferase levels compared with placebo over 96 weeks of treatment. (medpagetoday.com)
- Neither vitamin E nor metformin significantly decreased alanine aminotransferase (ALT) levels in children and adolescents with nonalcoholic fatty liver disease (NAFLD), researchers say. (medpagetoday.com)
- But, although the trial missed this primary endpoint of significant reductions in ALT levels compared with placebo, the vitamin may be able to mitigate the more progressive form of the disease, Joel Lavine, MD, PhD, of Columbia University Medical Center in New York, and colleagues reported in the April 27 issue of the Journal of the American Medical Association . (medpagetoday.com)
- NAFLD has become the most common cause of chronic liver disease in children in the U.S., Lavine and colleagues wrote. (medpagetoday.com)
- In those who are found to have fatty liver disease, they should undergo appropriate dietary and exercise lifestyle change," Lavine said in an interview with The JAMA Report . (medpagetoday.com)
- Liver transplantation is the only therapeutic option for patients with end stage liver disease resulting from this disorder. (nih.gov)
- This Clinical Procedure Training course gives experienced physicians the opportunity to fine-tune their practical skills and learn more about current treatment options for various stages of HCC and liver metastatic disease. (cirse.org)
- Theoretical presentations will be organised to allow participants to understand the staging and treatment algorithm of HCC and metastatic liver disease. (cirse.org)
- The American Liver Foundation helps support millions world-wide by providing information and learning opportunities, advocating for people with liver disease, providing support services and by funding research for the prevention of, the treatment of, and to find the cure for… liver disease. (liverfoundation.org)
- About 20% of patients, or 27,640, will present with or eventually develop metastatic disease confined to the liver . (cancernetwork.com)
- Liver disease can occur alone, from alcohol or medication side-effects, as part of other diseases, or as secondary to systemic sclerosis (scleroderma). (sclero.org)
- Lack of knowledge among community physicians may be keeping them from raising the possibility of living donor transplants with their patients with liver disease, new survey data suggest. (sclero.org)
- A system used to determine who is most in need of a transplant significantly underestimates the risk of death for younger children with liver disease, according to a new study. (sclero.org)
- Simple descriptions of dozens of liver diseases from Alagille Syndrome to Wilson's Disease. (sclero.org)
- Cryoglobulinemic Vasculitis (CV) in primary Sjögren's Syndrome pSS): Clinical presentation, association with lymphoma and comparison with Hepatitis C-related disease. (sclero.org)
- Prospective evaluation of a primary care referral pathway for patients with non-alcoholic fatty liver disease. (bioportfolio.com)
- liver disease. (bioportfolio.com)
- Primary Klebsiella pneumoniae liver abscess complicated with metastatic meningitis or endophthalmitis is a globally emerging infectious disease. (rupress.org)
- In the past 15 yr, a new type of invasive K. pneumoniae disease has emerged in Taiwan ( 4 - 10 ) that typically presents a community-acquired primary liver abscess with sepsis and bacteremia ( 4 , 5 ). (rupress.org)
- Variables included disease stage (new, established or complicated cases) and primary care use (low, medium or high). (mja.com.au)
- 7 , 8 Rates of potentially avoidable hospitalisations (PAHs) are indicators of access to primary care and include hospitalisations that may have been avoided by preventing illness or managing chronic disease. (mja.com.au)
- Primary biliary cirrhosis is considered an autoimmune disease, which means it is caused by the body's own immune system mistakenly attacking itself. (columbiasurgery.org)
- Although the causes of primary biliary cirrhosis are still not completely understood, it's thought to be an autoimmune disease. (columbiasurgery.org)
- These form an image of the liver and bile ducts so that doctors can better detect signs of disease. (columbiasurgery.org)
- There is evidence to suggest that rifampicin is an effective second line therapy for controlling pruritus in patients with chronic cholestatic liver disease. (bmj.com)
- It is most widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). (bmj.com)
- Rifampicin caused significant hepatitis in 7.3% (95% confidence interval 2.5-19.4%) of patients treated for cholestatic liver disease in our centre. (bmj.com)
- MONDAY, Dec. 31, 2018 (HealthDay News) - A nurse-led primary care intervention can increase the number of new diagnoses of liver disease, according to a study published online Dec. 21 in PLOS ONE . (physiciansweekly.com)
- To ascertain baseline prevalence of liver disease, pre-recruitment audits were carried out in each practice. (physiciansweekly.com)
- The researchers found that 49.5 and 39.1 percent of cases were due to nonalcoholic fatty liver disease and alcohol, respectively. (physiciansweekly.com)
- Incorporating a liver nurse within primary care was simple to arrange and yielded a much higher number of new diagnoses of liver disease compared to usual care," El-Gohary said in a statement. (physiciansweekly.com)
- Primary biliary cirrhosis (PBC) is an autoimmune disease. (ebscohost.com)
- Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, with a prevalence of 20-30% in the general population and 60-80% in at-risk populations. (elsevier.es)
- Sclerotherapy versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis. (medworm.com)
- In a prospectively planned, controlled study, COPD patients who participated in the "Living well with COPD" (LWWCOPD) self-management intervention were compared with usual care patients from the primary care COPD Cohort ICE COLD ERIC, who did not receive self-management intervention ( NCT00706602 ) The primary outcome was behaviour change and disease-specific health related quality of life after 1 year. (ersjournals.com)
- The Canadian disease management programme, "Living well with COPD" (LWWCOPD) ( www.livingwellwithcopd.com ), was probably the first COPD self-management programme based on a leading model of chronic disease management, known as the Chronic Care Model [ 1 ]. (ersjournals.com)
- Objectives To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting. (bmj.com)
- Participants Adult patients (aged 18 years or over) fulfilling one or more selected risk factors for developing chronic liver disease: (1) hazardous alcohol use, (2) type 2 diabetes or (3) persistently elevated alanine aminotransferase (ALT) liver function enzyme with negative serology. (bmj.com)
- The current study provides an alternative diagnostic algorithm to the usual flawed concept of investigating patients for liver disease on the basis of elevated liver function enzymes. (bmj.com)
- We introduced a novel algorithm that targets established risk factors for chronic liver disease in a primary care setting. (bmj.com)
- Putting non-alcoholic fatty liver disease on the radar for primary care physicians: how well are we doing? (biomedcentral.com)
- Non-alcoholic fatty liver disease (NAFLD) has emerged as a common cause of liver-related morbidity and mortality. (biomedcentral.com)
- Non-alcoholic fatty liver disease (NAFLD) has emerged as a common cause of chronic liver disease worldwide. (biomedcentral.com)
- Objective Evaluation of predictive value of liver function tests (LFTs) for the detection of liver-related disease in primary care. (bmj.com)
- Participants Patients (n=1290) with an abnormal eight-panel LFT (but no previously diagnosed liver disease). (bmj.com)
- Conclusions The LFT panel can be restricted to ALT and ALP when the purpose of testing is to exclude liver disease in primary care. (bmj.com)
- The prevalence of significant liver disease in people with incidental abnormal LFTs is little higher than the population prevalence. (bmj.com)
- Just two analytes (alanine aminotransferase and alkaline phosphatase) provide an efficient default testing strategy for excluding liver disease (of viral, genetic, autoimmune or neoplastic origin) in primary care. (bmj.com)
- This is the first large, prospective primary care-based study of patients with abnormal LFTs that were fully evaluated for liver disease. (bmj.com)
- This term should be included in a larger entity, called Non-Alcoholic Fatty Liver disease (NAFLD). (alliedacademies.org)
- However, despite treatment with ursodeoxycholic acid and improved disease awareness, the absolute annual number of liver transplantations has stabilised. (eur.nl)
- With this proposal, we aim to evaluate the feasibility and acceptability of distribution of chewing gums and/or gummy bear snacks containing at least one polyol on the primary prevention of periodontal disease in association with PTB and SGA births through the rural expansion of our current established community-based health care efforts in Lilongwe, Malawi. (savinglivesatbirth.net)
- Metastatic disease to the liver Treatment can consist of surgery (hepatectomy), chemotherapy and/or therapies specifically aimed at the liver like radiofrequency ablation, transcatheter arterial chemoembolization, selective internal radiation therapy and irreversible electroporation. (wikipedia.org)
- Bengmark S, Hafstrüm L, Jeppsson B, Sundquist K (1982) Primary carcinoma of the liver: improvement in sight? (springer.com)
- Lee NW, Wong I, Ong GB (1982) The surgical management of primary carcinoma of the liver. (springer.com)
- Okamoto E, Tanaka N, Yamanaka N, Toyosaka A (1984) Results of surgical treatments of primary hepatocellular carcinoma: some aspects to improve long-term survival. (springer.com)
- Background and Aim: Primary carcinosarcoma (CS) and sarcomatoid carcinoma (SC) of the liver are extremely rare malignancies composed of both carcinomatous and sarcomatous components. (sages.org)
- Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver: A study of 100 cases among 48900 necropsies. (springer.com)
- We examined as a possible useful system for studying the regulation of cytochrome P-450 3A under controlled conditions in vitro, primary monolayer cultures of human hepatocytes and compared the results with those obtained from the study of cytochrome P-450 3A in the human hepatoblastoma cell line HepG2 or in the human hepatocellular carcinoma cell line TONG/HCC. (nih.gov)
- The material for this study of primary carcinoma of the liver was derived from 24,400 consecutive autopsies performed at Bellevue Hospital from 1906 to 1936. (annals.org)
- The Clinical Aspects of Primary Carcinoma of the Liver: A Review of 53 Cases. (annals.org)
- Autoimmune hepatitis is an inflammation of the liver caused by an autoimmune disorder. (sclero.org)
- Objectives: to determine whether ursodeoxycholic acid (UDCA) is effective in improving primary biliary cirrhosis (PBC) or chronic hepatitis (CH). Methods: Meta-analysis (MA) was performed on nine papers and three abstracts describing PBC and on nine papers and two abstracts with CH that were published between 1985 and 1992 and were identified through MEDLINE. (ebscohost.com)
- Liver enzymes such as alanine aminotransferase (ALT) are also used as a surrogate for liver injury and, in the absence of alternate causes of liver injury such as viral hepatitis and in the presence of other risk factors for NAFLD such as obesity and type 2 diabetes, it is inferred that NAFLD is the cause of abnormal ALT. (biomedcentral.com)
Strains causing primary liver2
- All K. pneumoniae strains causing primary liver abscess have a unique antimicrobial susceptibility pattern (resistant to ampicillin, ticarcillin, and carbenicillin but susceptible to other antibiotics including all cephalosporins and aminoglycosides) ( 1 - 4 ). (cdc.gov)
- To identify factors that are unique, and so presumably vital to the virulence process, we compared strains causing primary liver abscess with strains not associated with liver abscess. (rupress.org)
- Primary angiosarcoma of the small intestine with metastasis to the liver: a case report and review of the literature. (biomedsearch.com)
- To the best of our knowledge, this may be the youngest case of primary angiosarcoma of the small intestine with metastasis to the liver reported in the English literature. (biomedsearch.com)
- To the best of our knowledge, few cases of primary angiosarcoma of the small intestine have been reported in the English literature [ 5 ], especially primary angiosarcoma of the small intestine with metastasis to the liver in a young patient. (biomedsearch.com)
- Liver metastasis-selective genes were identified by significance analysis of microarray (SAM) analyses and independently validated in external datasets. (aacrjournals.org)
- Patients with unresectable primary or secondary malignancies of the liver have limited treatment options which often only give a small survival benefit. (knowcancer.com)
- This study would establish the safety and efficiacy of RFA aspiration in the treatment of unresectable primary/secondary malignancies of the liver. (knowcancer.com)
- Cirrhosis "The end result of many forms of chronic liver injury is cirrhosis, or scarring of liver tissue in reponse to previous acinar necrosis and irregular regeneration of liver nodules and bile ducts. (sclero.org)
- The arrays included paired nonneoplastic and neoplastic liver tissue from each patient. (aacrjournals.org)
- The newly funded work will take advantage of Rajagopalan's in vitro three-dimensional liver mimic, an engineered functional tissue. (bio-medicine.org)
- This is a surgical procedure that removes a tiny portion of liver tissue so that doctors can examine it under a microscope to determine what is wrong. (columbiasurgery.org)
- We recently described a novel, near-physiological organoid culture system, wherein primary human healthy liver cells form long-term expanding organoids that retain liver tissue function and genetic stability. (eur.nl)
- Genome-wide studies in mouse livers and intestines suggest FXR's diverse and broadly tissue specific functions. (ku.edu)
- And so, the liver and other tissues are exposed to cytokines produced in adipose tissue. (alliedacademies.org)
- Bismuth H, Houssin D, Ornowski J, Meriggi F (1986) Liver resections in cirrhotic patients: a Western experience. (springer.com)
- Primary biliary cirrhosis (PBC) is a chronic autoimmune liver disorder characterised by slowly progressive destruction of intrahepatic bile ducts. (bmj.com)
- Bile is transported through small tubes (bile ducts) that carry bile through the liver and then from the liver to the gallbladder and to the small intestine. (merckmanuals.com)
- In very advanced cases of PBC, a liver transplant may be recommended. (virginiamason.org)
- Liver donation for transplant misunderstood, underutilized. (sclero.org)
- This retrospective study was based on the data of 82 female liver transplant recipients with PBC from a single institution. (curehunter.com)
- The primary aim for this trial is to assess whether the RFA aspirator device is safe and of clinical benefit in patients with primary or secondary malignant liver tumours. (knowcancer.com)
- A total of 910 participants were seen in the nurse-led clinic: 4.8 percent with probable cirrhosis, 15.5 percent with progressive fibrosis, 24.2 percent with liver warning, and 55.5 percent with no evidence of liver fibrosis. (physiciansweekly.com)
- Stage of liver fibrosis according to the CRN Fibrosis Staging Classification. (elsevier.es)
- Patients were investigated utilising simple and cheap blood-based biomarkers followed by transient elastography (a validated biomarker of liver fibrosis). (bmj.com)
- The results of liver transplantation for patients with clinically apparent cholangiocarcinoma are extremely poor, however in patients in whom a microscopic tumour is detected in the explanted liver, survival is similar to those transplanted with PSC without cholangiocarcinoma. (nih.gov)
- Two diabetic patients with primary liver abscess, who initially responded unsatisfactorily to intravenous ceftriaxone or cefoxitin treatment and had abscess drainage, were found to be infected with a single clone of Klebsiella pneumoniae with two different colonial morphotypes and resistotypes. (cdc.gov)
- Primary liver abscess caused by second-generation cephalosporin-resistant K. pneumoniae strains may be an emerging problem in Taiwan. (cdc.gov)
- Primary liver abscess caused by a single pathogen, Klebsiella pneumoniae , has long been an important infectious complication in diabetic patients in Taiwan ( 1 , 2 ). (cdc.gov)
- Although multidrug-resistant strains of K. pneumoniae, whether community acquired or nosocomial, are not uncommon in Taiwan and other countries, these isolates had never been reported as the cause of primary liver abscess ( 5 , 6 ). (cdc.gov)
- Colonial morphology of Klebsiella pneumoniae grown on a primary isolation plate (trypticase soy agar supplemented with 5% sheep blood) from the abscess aspirate of patient A after 24 hours of incubation. (cdc.gov)
- Physical examination and abdominal echography showed hepatomegaly and a huge abscess (12 cm x 10 cm x 8 cm) over the right lobe of the liver. (cdc.gov)
- Abdominal echography and computed tomography revealed an abscess (6 cm x 4 cm x 4 cm) over the right lobe of the liver and a gallbladder stone. (cdc.gov)
- Data for potential risk factors were reviewed retrospectively and analyzed for the frequency of infectious complications, including abscess formation.ResultsOne patient (1/121 (0.8 %) RFA sessions) developed a large segment 5 liver abscess/infected biloma communicating with the gallbladder 7 weeks after the procedure, successfully treated over 10 weeks with IV and PO antibiotic therapy and percutaneous catheter drainage. (osti.gov)
- Differences in mucoviscosity were observed between strains that caused primary liver abscess (invasive) and those that did not (noninvasive). (rupress.org)
- Nevertheless, mortality rates as high as 10% for primary liver abscess ( 4 - 9 ) and 30-40% among those with metastatic meningitis have been reported ( 11 , 12 ). (rupress.org)
- Among the total of 1,352 isolates obtained from patients with septicemia, 101 strains were obtained from patients displaying primary liver abscess. (rupress.org)
- Of the remaining 1,251 patients who did not display clinical symptoms of liver abscess, meningitis, or endophthalmitis, 52 patients were confirmed to be free of abscess by either abdominal sonography or computed tomography. (rupress.org)
- We conclude that liver transplantation is an efficacious treatment in patients with advanced primary biliary cirrhosis. (nih.gov)
- This add-on study of providing tobacco, alcohol and other drug screening, brief intervention and referral for treatment to a primary care high risk diabetic population leverages the existi. (bioportfolio.com)
- Treatment focuses on relieving symptoms, but liver transplantation can prolong life. (merckmanuals.com)
- HepG2 cells contained only 3A7 protein, a form found in human fetal liver, even after treatment with inducers. (nih.gov)
- Conclusions: MA confirmed a beneficial effect of UDCA in PBC on liver tests, histology, and treatment failure. (ebscohost.com)
- Research progress in medical treatment of primary biliary cirrhosis. (ebscohost.com)
- An alternate perspective is that NAFLD is a very common condition where the majority of individuals do not have a liver-related outcome and current efforts to raise awareness may lead to 'fear mongering', over investigation, and even over treatment. (biomedcentral.com)
- However, RNA-seq and microarray showed more different transcriptome profiles between PHHs and mouse livers upon GW4064 treatment. (ku.edu)
- When pooled in MA, UDCA improved the liver histology (p lt 0.001) and prevented treatment failure (p lt 0.04). (eurekamag.com)
- The authors underscore the need for physician education and for development of simple evaluation tools that are both robust and implementable in a primary care setting, along with effective therapeutics to overcome this apathy towards NAFLD. (biomedcentral.com)
- She is a past recipient of a National Science Foundation CAREER Award to fund her work on cell migration, and in the past two years she has received more than $1 million in funding to create and study engineered tissues that mimic the human liver. (bio-medicine.org)
- Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. (nih.gov)
- The cytochrome P-450 3A gene family comprises the dominant forms of cytochrome P-450 found in human liver. (nih.gov)
- In this study, cytochrome P450 enzymes responsible for the primary and sequential oxygenation reactions of capravirine in human liver microsomes were identified at the specific pathway level. (aspetjournals.org)
- The purpose of the present study was to identify the P450 enzyme(s) responsible for each of the primary and sequential oxygenation reactions of capravirine in human liver microsomes. (aspetjournals.org)
- Human liver microsomes (pooled from 14 donors) were prepared at Pfizer (Groton, CT). (aspetjournals.org)
- 14 C]Capravirine (2 μM) was incubated for varying times (0-1 h) at 37°C in an incubation system consisting of 100 mM potassium phosphate buffer (pH 7.4), 0.2 mg of human liver microsomes, and 1 mM NADPH in a final volume of 1 ml. (aspetjournals.org)
- Chloride-bicarbonate anion exchanger 2 (AE2) is expressed in a variety of tissues, including the liver and salivary glands, where it may participate in the generation of hydroionic fluxes into secretions. (cun.es)
Transplantation for primary2
- The liver is in the upper abdomen near the stomach, intestines, gallbladder, and pancreas. (vicc.org)
- PNAC is predominately found in preterm infants and neonates, and has high rate of progression into liver failure. (ku.edu)
- Method: A cross-sectional study was performed to study a sample of 100 patients attending Primary Care with 2 or more cardiovascular risk factors and no alcohol consumption. (alliedacademies.org)
- Therefore it is recommended that upon the appearance of these risk factors, liver should be tested. (alliedacademies.org)
- Did they have symptomatic primaries? (mdedge.com)
- Hänninen EL, Vogl TJ, Felfe R, Pegios W, Balzer J, Clauss W, Felix R (2000) Detection of focal liver lesions at biphasic spiral CT: randomized, double-blind study of the effect of iodine concentration in contrast materials. (springer.com)
- Large heterogeneous lesions of the liver are rarely resectable for cure. (appliedradiology.com)
- Ursodeoxycholic acid can reduce bile build-up and improve liver function. (virginiamason.org)
- Ursodeoxycholic Acid for Patients With Primary Biliary Cirrhosis: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials Using Bayesian Approach as Sensitivity Analyses. (ebscohost.com)
- OBJECTIVES: Ursodeoxycholic acid (UDCA) is used for primary biliary cirrhosis (PBC), but the beneficial effects remain controversial. (ebscohost.com)
- Prolonged Follow-Up of Patients in the U.S. Multicenter Trial of Ursodeoxycholic Acid for Primary Biliary Cirrhosis. (ebscohost.com)
- They reported some of their findings earlier this year at the American Association for the Study of Liver Diseases meeting in Boston. (medpagetoday.com)
- What are the diseases that affect the liver? (sclero.org)
- Main outcome measures Patients were investigated by recording clinical features, and repeating LFTs, specific tests for individual liver diseases, and abdominal ultrasound scan. (bmj.com)
- FXR deficiency is implicated in numerous liver diseases and mice with modulation of FXR have been used as animal models to study liver physiology and pathology. (ku.edu)
- Recent studies in the field of parenteral nutrition (PN) suggest that down-regulation of FXR signaling is critically involved in the pathogenesis of PN associated liver diseases (PNALD), especially PN associated cholestasis (PNAC) in preterm infants. (ku.edu)
- However, long-term PN can lead to a spectrum of liver diseases, summarized as PNALD. (ku.edu)
Necessitating liver transplantation1
- Two of these patients had significant impairment of liver synthetic function (necessitating liver transplantation in one case). (bmj.com)
- Most patients respond well to medications prescribed by their provider to improve liver function, minimize symptoms like itching and fatigue, and prevent complications. (virginiamason.org)
- This was largely attributable to diabetes complications, and highlights barriers to accessing effective primary care. (mja.com.au)
- But as damage to the liver becomes more severe, serious health complications can emerge. (columbiasurgery.org)
- Successfully managing the symptoms and complications of primary biliary cirrhosis will depend on multiple factors. (columbiasurgery.org)
- Farnesoid X receptor (FXR, NR1H4) is a ligand activated transcription factor belonging to the nuclear receptor (NR) superfamily, and is highly expressed in the liver, intestine, and kidney, in both humans and rodents. (ku.edu)
- In cultures of hepatocytes from the remaining four human livers that did not contain 3A5 mRNA or protein, we detected neither spontaneous nor inducible 3A5 proteins or mRNAs. (nih.gov)
- 2. Despite their frequent use in drug research, little is known about the expression of genes coding for transporters in cultures of primary sandwiched hepatocytes. (fraunhofer.de)
- 3. The kinetics of gene expression of canalicular and basolateral membrane transporters in cultures of primary rat sandwiched hepatocytes were investigated, and the expression of cMOAT, spgp, mdr1a and mdr2 were shown to be comparable with transcript levels observed in vivo. (fraunhofer.de)
- In the first aim, we studied the genome-wide FXR binding and transcriptome profiles upon FXR activation in primary human hepatocytes (PHHs) and HepG2 cells. (ku.edu)
- Ultimately, the trial missed its primary endpoint of sustained reduction in ALT levels, which was not significantly different between groups: 17% of placebo patients achieved sustained response by the end of the study, compared with 26% of vitamin E patients and 16% of of those on metformin. (medpagetoday.com)
- The primary objective of the study is to determine the safety and tolerability of CC-122 administered orally in combination with sorafenib, and to define the non-tolerated dose (NTD), the maximum tolerated dose (MTD), and the recommended phase 2 dose (RP2D). (clinicaltrials.gov)
- Children lose out on liver transplants, study finds. (sclero.org)
- This low interventional study, whose unique intervention will be to measure the blood level of a biomarker called NT-proBNP in chronic heart failure patients daily followed-up by Primary C. (bioportfolio.com)
- During the arterial phase of the study, HCC enhances more intensely than the surrounding liver because the arterial blood in the liver is diluted by venous blood that does not contain contrast, whereas the HCC contains only arterial blood. (unchealthcare.org)
- To our knowledge, only one previous comparative study specifically evaluated the LWWCOPD intervention with patients in primary care [ 12 ]. (ersjournals.com)
- Reflective and process-based notes from all meetings of the project partners, interview data, and data of focus groups were analyzed systematically using four theoretical models to study the adoption of eHealth in primary care. (jmir.org)