Tumors or cancer of the LIVER.
Experimentally induced tumors of the LIVER.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Pathological processes of the LIVER.
The transference of a part of or an entire liver from one human or animal to another.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Repair or renewal of hepatic tissue.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Neoplasms containing cyst-like formations or producing mucin or serum.
Extracts of liver tissue containing uncharacterized specific factors with specific activities; a soluble thermostable fraction of mammalian liver is used in the treatment of pernicious anemia.
The circulation of BLOOD through the LIVER.
Tumors or cancer of the SKIN.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
Tumors or cancers of the KIDNEY.
Excision of all or part of the liver. (Dorland, 28th ed)
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Tumors or cancer of the LUNG.
DNA present in neoplastic tissue.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Tumors or cancer of the PAROTID GLAND.
Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.
Glycogen stored in the liver. (Dorland, 28th ed)
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Tumors or cancer of the ENDOCRINE GLANDS.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Tumors or cancer of the BILE DUCTS.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Elements of limited time intervals, contributing to particular results or situations.
Tumors or cancer of the NOSE.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the SALIVARY GLANDS.
A benign epithelial tumor with a glandular organization.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
Tumors or cancer of the INTESTINES.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Tumors or cancer of the COLON.
A general term for various neoplastic diseases of the lymphoid tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
A benign epithelial tumor of the LIVER.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
Tumors or cancer of the UTERUS.

Intensive investigation in management of Hodgkin's disease. (1/16288)

Ninety-eight patients with clinically localised Hodgkin's disease underwent laparotomy and splenectomy to determine the extent of microscopic spread. In 68 patients the procedure was carried out for untreated disease apparently confined above the diaphragm. Abdominal disease cannot be confidently excluded on the basis of non-invasive investigation at presentation. Clinical assessment of splenic disease was unreliable unless gross splenomegaly was present. Pedal lymphography was accurate in assessing para-aortic and iliac disease but of no value in assessing other intra-abdominal lymph node involvement, including that of the mesenteric lymph node. Trephine bone marrow biopsy findings were normal in all patients before surgery, and only one patient was found to have diseased bone marrow by Stryker-saw biopsy at operation. Liver disease was identified at operation in nine patients, some of whom were asymptomatic with clinically undetectable splenic and nodal disease. Detailed clinical staging failed to detect disease in one-third of patients who underwent laparotomy. These studies show that if radiotherapy is to remain the treatment of choice for disease truly localised to lymph nodes a detailed staging procedure, including laparotomy and splenectomy, remains essential. The value of this potentially curative treatment is considerably diminished in the patient who has been inadequately staged.  (+info)

Peripheral hepatojejunostomy as palliative treatment for irresectable malignant tumors of the liver hilum. (2/16288)

OBJECTIVE: To evaluate the concept of surgical decompression of the biliary tree by peripheral hepatojejunostomy for palliative treatment of jaundice in patients with irresectable malignant tumors of the liver hilum. SUMMARY BACKGROUND DATA: Jaundice, pruritus, and recurrent cholangitis are major clinical complications in patients with obstructive cholestasis resulting from malignant tumors of the liver hilum. Methods for palliative treatment include endoscopic stenting, percutaneous transhepatic drainage, and surgical decompression. The palliative treatment of choice should be safe, effective, and comfortable for the patient. METHODS: In a retrospective study, surgical technique, perioperative complications, and efficacy of treatment were analyzed for 56 patients who had received a peripheral hepatojejunostomy between 1982 and 1997. Laparotomy in all of these patients had been performed as an attempt for curative resection. RESULTS: Hepatojejunostomy was exclusively palliative in 50 patients and was used for bridging to resection or transplantation in 7. Anastomosis was bilateral in 36 patients and unilateral in 20. The 1-month mortality in the study group was 9%; median survival was 6 months. In patients surviving >1 month, a marked and persistent decrease in cholestasis was achieved in 87%, although complete return to normal was rare. Among the patients with a marked decrease in cholestasis, 72% had no or only mild clinical symptoms such as fever or jaundice. CONCLUSIONS: Peripheral hepatojejunostomy is a feasible and reasonably effective palliative treatment for patients with irresectable tumors of the liver hilum. In patients undergoing exploratory laparotomy for attempted curative resection, this procedure frequently leads to persistent-although rarely complete-decompression of the biliary tree. In a few cases it may also be used for bridging to transplantation or liver resection after relief of cholestasis.  (+info)

Risk of major liver resection in patients with underlying chronic liver disease: a reappraisal. (3/16288)

OBJECTIVE: To explore the relation of patient age, status of liver parenchyma, presence of markers of active hepatitis, and blood loss to subsequent death and complications in patients undergoing a similar major hepatectomy for the same disease using a standardized technique. SUMMARY BACKGROUND DATA: Major liver resection carries a high risk of postoperative liver failure in patients with chronic liver disease. However, this underlying liver disease may comprise a wide range of pathologic changes that have, in the past, not been well defined. METHODS: The nontumorous liver of 55 patients undergoing a right hepatectomy for hepatocellular carcinoma was classified according to a semiquantitative grading of fibrosis. The authors analyzed the influence of this pathologic feature and of other preoperative variables on the risk of postoperative death and complications. RESULTS: Serum bilirubin and prothrombin time increased on postoperative day 1, and their speed of recovery was influenced by the severity of fibrosis. Incidence of death from liver failure was 32% in patients with grade 4 fibrosis (cirrhosis) and 0% in patients with grade 0 to 3 fibrosis. The preoperative serum aspartate transaminase (ASAT) level ranged from 68 to 207 IU/l in patients with cirrhosis who died, compared with 20 to 62 in patients with cirrhosis who survived. CONCLUSION: A major liver resection such as a right hepatectomy may be safely performed in patients with underlying liver disease, provided no additional risk factors are present. Patients with a preoperative increase in ASAT should undergo a liver biopsy to rule out the presence of grade 4 fibrosis, which should contraindicate this resection.  (+info)

Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. (4/16288)

OBJECTIVE: This study aimed to evaluate the long-term results of treatment and prognostic factors in patients with intrahepatic recurrence after curative resection of hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: Recent studies have demonstrated the usefulness of re-resection, transarterial oily chemoembolization (TOCE), or percutaneous ethanol injection therapy (PEIT) in selected patients with intrahepatic recurrent HCC. The overall results of a treatment strategy combining these modalities have not been fully evaluated, and the prognostic factors determining survival in these patients remain to be clarified. METHODS: Two hundred and forty-four patients who underwent curative resection for HCC were followed for intrahepatic recurrence, which was treated aggressively with a strategy including different modalities. Survival results after recurrence and from initial hepatectomy were analyzed, and prognostic factors were determined by univariate and multivariate analysis using 27 clinicopathologic variables. RESULTS: One hundred and five patients (43%) with intrahepatic recurrence were treated with re-resection (11), TOCE (71), PEIT (6), systemic chemotherapy (8) or conservatively (9). The overall 1-year, 3-year, and 5-year survival rates from the time of recurrence were 65.5%, 34.9%, and 19.7%, respectively, and from the time of initial hepatectomy were 78.4%, 47.2%, and 30.9%, respectively. The re-resection group had the best survival, followed by the TOCE group. Multivariate analysis revealed Child's B or C grading, serum albumin < or = 40 g/l, multiple recurrent tumors, recurrence < or = 1 year after hepatectomy, and concurrent extrahepatic recurrence to be independent adverse prognostic factors. CONCLUSIONS: Aggressive treatment with a multimodality strategy could result in prolonged survival in patients with intrahepatic recurrence after curative resection for HCC. Prognosis was determined by the liver function status, interval to recurrence, number of recurrent tumors, any concurrent extrahepatic recurrence, and type of treatment.  (+info)

Tumour ablation and hepatic decompensation rates in multi-agent chemoembolization of hepatocellular carcinoma. (5/16288)

Thirty-seven cirrhotic patients with 62 hepatocellular carcinoma (HCC) foci--most Child-Pugh class B or C and/or with large, inoperable tumours--underwent 148 sessions of transcatheter arterial chemoembolization (TACE) using lipiodol, doxorubicin and cisplatin. Treatment efficacy was assessed by serial hepatic arteriography in 34/37 (91.9%) patients and abdominal CT scanning in 3/37 (8.1%) patients. Child-Pugh status was determined prior to each treatment session. Varying degrees of control of tumour neovascularity occurred for a median 390 days (range 90 to > 1680 days) in 33/34 (97.1%) patients in whom progress hepatic arteriography was performed. Ablation of tumour neovascularity occurred in 6/6 (100%), 4/12 (33.3%) and 6/16 (37.5%) patients with HCC diameters < 4 cm, 4-7 cm and > 8 cm, respectively (p < 0.02). Significantly more sessions were required for ablation of larger tumours (p < 0.05). Recurrent HCC was detected in 50% of patients after a median 240 days (range 60-1120 days). Deterioration in Child-Pugh status followed a session of TACE on 19/148 (12.8%) occasions but resulted in unscheduled hospitalization on only 4/148 (2.7%) occasions, the highest incidence (8.3%) in Child-Pugh C patients. Actuarial survival was 27/36 (75.0%) at 6 months, 17/34 (50.0%) at 12 months, 14/34 (41.2%) at 18 months, 9/31 (29.0%) at 24 months and 4/27 (14.8%) at 36 months. Multi-agent TACE with lipiodol, doxorubicin and cisplatin provides a useful anti-tumour effect, even in cirrhotic patients with large HCCs. The incidence of clinically significant deterioration in hepatic function due to ischaemia of non-tumorous liver is acceptably low, even in Child-Pugh C patients.  (+info)

Detection of liver metastases from pancreatic cancer using FDG PET. (6/16288)

We evaluated the potential of the glucose analog [18F]fluorodeoxyglucose (FDG) as a PET tracer for the hepatic staging in 168 patients designated for resective pancreatic surgery. METHODS: Metastatic liver disease was confirmed or excluded during surgery or with CT follow-up for at least 6 mo. Proven metastases were then retrospectively identified on preoperative CT (gold standard). Hepatic PET scans of all patients were interpreted blindly. Any focal FDG uptake was considered malignant. Both proven hepatic metastases and suspicious hepatic PET lesions were then compared, lesion by lesion, with CT. Standardized uptake values (SUV) and tumor-to-liver ratios (T/L) were determined for the most intense lesion of each patient. RESULTS: Sensitivity of FDG PET was 68% (15 of 22 patients). The lesion detection rate was 97% (28 of 29 metastases) for lesions >1 cm and 43% (16 of 37 metastases) for lesions < or = 1 cm. Specificity was 95% (138 of 146 patients). Six of eight patients with false-positive results had marked intrahepatic cholestasis (versus 3 of 15 patients with true-positive lesions), one had an infrahepatic abscess and one had a right basal pulmonary metastasis. The SUV and T/L were 4.6+/-1.4 and 2.3+/-1.1, respectively, for malignant lesions and 4.1+/-1.5 and 1.9+/-0.3, respectively, for false-positive lesions and therefore are of limited value. CONCLUSION: FDG PET provides reliable hepatic staging for lesions >1 cm. False-positive results are associated with the presence of marked intrahepatic cholestasis. For lesions < or = 1 cm, FDG PET can define malignancy in 43% of suspicious CT lesions in the absence of dilated bile ducts.  (+info)

Clinical significance of circulating anti-p53 antibodies in European patients with hepatocellular carcinoma. (7/16288)

p53 alterations are considered to be predictive of poor prognosis in hepatocellular carcinoma (HCC) and may induce a humoral response. Anti-p53 serum antibodies were assessed by enzyme-linked immunosorbent assay (ELISA) using purified recombinant human p53 on 130 European HCC patients before treatment and during the clinical course of the disease. p53 immunohistochemistry was performed on tumours from the 52 patients who underwent surgery, and DNA sequencing analysis was initiated when circulating anti-p53 antibodies were detected. Nine (7%) HCC patients had anti-p53 serum antibodies before treatment. During a mean period of 30 months of follow-up, all the negative patients remained negative, even when recurrence was observed. Of the nine positive patients, eight were still positive 12-30 months after surgery. The presence of anti-p53 serum antibodies was correlated neither with mutation of the p53 gene nor the serum alpha-fetoprotein levels and clinicopathological characteristics of the tumours. However, a greater incidence of vascular invasion and accumulation of p53 protein were observed in the tumours of these patients (P<0.03 and P<0.01 respectively) as well as a better survival rate without recurrence (P = 0.05). In conclusion, as was recently shown in pancreatic cancer, anti-p53 serum antibodies may constitute a marker of relative 'good prognosis' in a subgroup of patients exhibiting one or several markers traditionally thought to be of bad prognosis.  (+info)

Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas. (8/16288)

To examine the association between gallstones and cholecystectomy, we conducted a nationwide population-based cohort study in Denmark. Patients with a discharge diagnosis of gallstones from 1977 to 1989 were identified from the Danish National Registry of Patients and followed up for cancer occurrence until death or the end of 1993 by record linkage to the Danish Cancer Registry. Included in the cohort were 60 176 patients, with 471 450 person-years of follow-up. Cancer risks were estimated by standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) stratified by years of follow-up and by cholecystectomy status. Among patients without cholecystectomy, the risks at 5 or more years of follow-up were significantly elevated for cancers of liver (SIR = 2.0, CI = 1.2-3.1) and gallbladder (SIR = 2.7, CI = 1.5-4.4) and near unity for cancers of extrahepatic bile duct (SIR = 1.1), ampulla of Vater (SIR = 1.0) and pancreas (SIR = 1.1). The excess risk of liver cancer was seen only among patients with a history of hepatic disease. Among cholecystectomy patients, the risks at 5 or more years of follow-up declined for cancers of liver (SIR = 1.1) and extrahepatic bile duct (SIR = 0.7), but were elevated for cancers of ampulla of Vater (SIR = 2.0, CI = 1.0-3.7) and pancreas (SIR = 1.3, CI = 1.1-1.6). These findings confirm that gallstone disease increases the risk of gallbladder cancer, whereas cholecystectomy appears to increase the risk of cancers of ampulla of Vater and pancreas. Further research is needed to clarify the carcinogenic risks associated with gallstones and cholecystectomy and to define the mechanisms involved.  (+info)

TY - JOUR. T1 - Isolated hepatic perfusion for unresectable hepatic metastases from colorectal cancer. AU - Bartlett, David L.. AU - Libutti, Steven K.. AU - Figg, William D.. AU - Fraker, Douglas L.. AU - Richard Alexander, H.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Background. Unresectable colorectal liver metastases are a significant clinical problem. Isolated hepatic perfusion (IHP) is a regional treatment technique that delivers high dose chemotherapy, biologic agents, and hyperthermia via a completely isolated vascular recirculating perfusion circuit as a means of regionally treating liver tumors. This study presents our results of IHP with tumor necrosis factor (TNF) plus melphalan or IHP with melphalan alone followed by infusional floxuridine (FUDR) and leucovorin in patients with advanced or refractory unresectable hepatic colorectal metastases. Methods. Fifty-one patients with unresectable colorectal hepatic metastases underwent a 60-minute IHP with 1.5 mg/kg melphalan and hyperthermia ...
Addition of selective internal radiation therapy (SIRT) failed to improve progression-free survival in non-resectable colorectal cancer liver metastases.
Eicosapentaenoic acid (EPA) is a naturally occuring omega-3 polyunsaturated fatty acid found in oily fish. EPA has anti-colorectal (bowel) cancer activity in experimental models. This trial will test whether EPA reduces markers of tumour growth, and is safe and well tolerated,in patients with colorectal cancer liver metastases awaiting surgery ...
Estrogen plays an important role in the development of some cancers. However, previous studies on the influence of estrogen on colorectal cancer (CRC) have had conflicting conclusions, and there have been few reports on estrogens and liver metastasis. The aim of this study was to explore the prognostic impact of estrogens on CRC with liver metastasis. Eighty-six patients with CRC including 43 synchronous liver metastases were studied. Estrogen receptor β (ERβ) levels were assayed by immunohistochemistry in liver metastasis, CRC and adjacent normal tissues. Serum estrogen levels were measured by radioimmunoassay. The correlation between staining, clinicopathological parameters, and prognostic power were analyzed statistically. Significant differences were found in ERβ expression between liver metastasis (P = 0.012) and CRC (P = 0.002) compared to adjacent normal tissues. Serum estrogen levels in patients with liver metastases were significantly lower than those without liver metastasis (P = 0.012).
BioAssay record AID 228035 submitted by ChEMBL: Inhibitory activity against Colchicine resistant parent primary liver carcinoma (PLC) cell line PLC/PRF/5.
TY - JOUR. T1 - Effect of the molar ratio of branched-chain to aromatic amino acids on growth and albumin mRNA expression of human liver cancer cell lines in a serum-free medium. AU - Saito, Y.. AU - Saito, H.. AU - Nakamura, M.. AU - Wakabayashi, K.. AU - Takagi, T.. AU - Ebinuma, H.. AU - Ishii, H.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Supplementation of branched-chain amino acids (BCAAs) is often used for the treatment of hepatic encephalopathy and low albuminemia in Japan. In this scenario, although many cases are complicated with hepatocellular carcinoma in chronic viral infection, the effect of BCAA levels on hepatocellular carcinoma cells remains unclear. We investigated the effect of the molar ratios of BCAAs to aromatic amino acids (AAAs) on the growth and albumin mRNA expression of cultured human liver cancer cell lines, HCC-M, HCC-T, PLC/PRF/5, and Hep G2. To exclude the effect of fetal serum in culture media on modification of the growth and albumin transcription of cell lines, we used ...
This multicentre, international, prospective observational study conducted in European centres plans to collect real-life data. This data will form an evidence-base from which conclusions can be drawn on how to improve patient selection and optimise treatment protocols when treating with TACE using …
Patients treated by liver resection had the best outcome, while patients with extrahepatic diseases had poor prognosis. The prognosis of patients treated by regional chemotherapy improved significantly with the advent of irinotecan and better selection.
The liver is an organ that develops primary and metastatic tumors. Hepatocellular carcinoma (HCC) is the fifth common type of cancer worldwide and the third leading cause of cancer death (1). The median survival is approximately 6 to 20 months after diagnosis for the intermediate and advanced stages, and the 5-year survival of patients with HCC is less than 30%. Even after apparently curative surgical resection, recurrent HCC develops in 80% of patients within 5 years because of intrahepatic metastasis. For unresectable HCC, different treatment modalities are available, including radiation, radioembolization, systemic chemotherapy, and molecularly targeted therapy. Oral sorafenib, which is a multityrosine kinase inhibitor, is currently the first-line treatment for advanced HCC but its effectiveness is limited (2). The liver is also a common site of metastasis from other solid tumors, especially tumors originating from the intra-abdominal organs, including the stomach, pancreas, colon, ...
TY - JOUR. T1 - Pathology of primary liver cancer. AU - Lapis, Károly. AU - Johannessen, Jan Vincents. PY - 1979/1/1. Y1 - 1979/1/1. N2 - After a brief survey of the factors that play a role in the etiopathogenesis of human hepatocellular carcinomas, a detailed description is given of the macroscopic and microscopic features of human liver cancers as well as their association with cirrhosis. The ultrastructural features of liver cancers of various degrees of differentiation are described. The mode of spread, metastasis formation of primary liver cancers, and most frequent causes of death of liver cancer patients are reviewed.. AB - After a brief survey of the factors that play a role in the etiopathogenesis of human hepatocellular carcinomas, a detailed description is given of the macroscopic and microscopic features of human liver cancers as well as their association with cirrhosis. The ultrastructural features of liver cancers of various degrees of differentiation are described. The mode of ...
CHICAGO -- Bevacizumab (Avastin) given before surgery for curative resection of liver metastases from colorectal cancer did not increase the risk of bleeding, researchers reported here.
A study released in the July 2016 issue of the American Journal of Roentgenology found that biphenotypic primary liver carcinoma may be misclassified as hepatocellular carcinoma.
Background After surgical resection of hepatocellular carcinoma (HCC), recurrence is common, especially in patients presenting with vascular invasion or multifocal disease after curative surgery. Consequently, we examined the expression pattern and prognostic value of miR-19b in samples from these patients. Methods We performed a miRNA microarray to detect differential expression of microRNAs (miRNAs) in 5 paired samples of HCC and non-tumoral adjacent liver tissue and a quantitative real-time polymerase chain reaction (PCR) analysis to validate the results in 81 paired samples of HCC and adjacent non-tumoral liver tissues. We examined the associations of miR-19b expression with clinicopathological parameters and survival. MiR-19b was knocked down in Hep3B and an mRNA microarray was performed to detect the affected genes. Results In both the miRNA microarray and real-time PCR, miR-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P < 0.001). The ...
Background After surgical resection of hepatocellular carcinoma (HCC), recurrence is common, especially in patients presenting with vascular invasion or multifocal disease after curative surgery. Consequently, we examined the expression pattern and prognostic value of miR-19b in samples from these patients. Methods We performed a miRNA microarray to detect differential expression of microRNAs (miRNAs) in 5 paired samples of HCC and non-tumoral adjacent liver tissue and a quantitative real-time polymerase chain reaction (PCR) analysis to validate the results in 81 paired samples of HCC and adjacent non-tumoral liver tissues. We examined the associations of miR-19b expression with clinicopathological parameters and survival. MiR-19b was knocked down in Hep3B and an mRNA microarray was performed to detect the affected genes. Results In both the miRNA microarray and real-time PCR, miR-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P < 0.001). The ...
Melanomul conjunctival Melanomul conjunctival este foarte rar. Pot exista motive ereditare pentru renașterea lor. Melanomul în iris apare în partea din față, partea colorată a ochiului.
Radioembolization (RE) is an emerging treatment strategy for patients with primary hepatic malignancies and metastatic liver disease. Though RE is primarily performed in the palliative setting, a shift toward the curative setting is seen. Currently, hepatic resection and in selected cases liver transplantation are the only curative options for patients ... read more with a hepatic malignancy. Unfortunately, at diagnosis most patients are not eligible for liver surgery due to the imbalance between the necessary liver resection and the remaining liver remnant. However, in borderline resectable cases, tumor volume reduction and/or increasing the future liver remnant can lead to a resectable situation. The combination of selective tumor treatment, the induction of hypertrophy of untreated liver segments, and its favourable toxicity profile make RE an appealing strategy for downstaging. The present review discusses the possibilities for RE in the preoperative setting as a downstaging tool or as a ...
Dr Philippa Matthews and colleagues review the associations between liver cancer risk and co-morbidities and other metabolic factors in individuals with chronic hepatitis B virus infection.
Metastatic liver cancer occurs due to the spreading of a primary cancer to the liver. Though incurable, you can try various treatment measures to get relief.
Background Age-adjusted liver cancer mortality rates have been increasing for both men and women in Japan since 1970 ; however, increases in mortality rates in men are much greater than those in women. Hepatitis C virus infections and heavy alcohol consumption are considered to be the major risk factors of liver cancer deaths in Japanese. The...
Featured Article: Phase II Trial of Hepatic Artery Infusional and Systemic Chemotherapy for Patients With Unresectable Hepatic Metastases From Colorectal Cancer: Conversion to Resection and Long-term Outcomes. Dangelica MI, Correa-Gallego C, Paty PB, et al. Ann Surg. 2014 Mar 21. [Epub ahead of print]. Summary: The rate of conversion of unresectable colorectal liver metastases (CRLM) to resectable CRLM has improved with modern systemic chemotherapy and biologic therapy. Results of recent studies, including randomized trials, report conversion rates of 20-38%. The combination of hepatic artery infusional (HAI) chemotherapy with systemic chemotherapy has become an attractive option for the treatment of unresectable CRLM owing to the high response rates observed in previous published studies.. This prospective phase II trial aimed to evaluate, as a primary endpoint, the conversion rate to complete resection (resectability rate) in patients with unresectable CRLM treated with HAI fluorodeoxyuridine ...
REFERENCES 1 Landis SH, Murray T, Bolden S, et al. Cancer Statistics. CA Cancer J Clin. 1999;49:8-31. 2 American Cancer Society.Cancer Facts & Figures, 2013.Atlanta, ACS, 2013:5. 3 Seidensticker R, Denecke T, Kraus P, et al. Matched-pair comparison of radioembolization plus best supportive care versus best supportive care alone for chemotherapy refractory liver-dominant colorectal metastases. Cardiovasc Intervent Radiol. 2011 July 29. [Epub ahead of print] 4 Jakobs TF, Hoffman RT, Dehm K, et al. Hepatic yttrium-90 radioembolization of chemotherapy-refractory colorectal cancer liver metastases. J Vasc Interv Radiol. 2008;19(8):1187-1195. 5 Gray B, van Hazel G, Hope M, et al. Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol. 2001;12(12):1711-1720. 6 van Hazel G, Blackwell A, Anderson J, et al. Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus ...
The latest liver cancer risk factors statistics for the UK for Health Professionals. See data for factors associated with increased risk, decreased or no risk and more.
HONGFU, Liu et al. The Role and Significance of Bcl-2 and Bax in the Hepatic Carcinoma. Int. J. Morphol. [online]. 2012, vol.30, n.4, pp.1466-1473. ISSN 0717-9502. http://dx.doi.org/10.4067/S0717-95022012000400032.. This study aimed to observe the regularity of liver cell apoptosis and expression of apoptosis related gene Bcl-2 and Bax in the induced cancer, and explore the relationship between apoptosis and the development of liver cancer. In this study, 84 rats were used, 72 rats as experimental group induced by drinking water containing DEN, 12 rats as control group (CG). After laparotomy, the form, color, texture of the liver and metastatic tumor in both control and experimental groups were observed and recorded. The metastatic tumor and the liver tissue were sectioned and stained with hematoxylin-eosin staining to demonstrate the characteristic in morphological changes, the Hoechst 33342 fluorescent staining was applied to show and count the rate of apoptotic cell, and the in situ ...
BACKGROUND: Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differences in the genomic profile needs to be clarified.. METHODS: Fresh-frozen tissue from primary tumours, synchronous liver metastases and adjacent normal liver was collected from 21 patients and analysed by whole-exome sequencing on the Illumina HiSeq 2500 platform. Gene variants designated as damaging or potentially damaging by Ingenuity software were used for the subsequent comparative analysis. BAM files were used as the input for the analysis of CNAs using NEXUS software.. RESULTS: Shared mutations between the primary tumours and the synchronous liver metastases varied from 50 to 96%. Mutations in APC, KRAS, NRAS, TP53 or BRAF were concordant between the primary tumours and ...
Despite the use of alternative therapy strategies surgical resection of colorectal liver metastases remains the treatment of choice and is associated with long-term survival in a significant number of patients [1, 2]. After curative resection of colorectal liver metastases the 5-year survival rate ranges from 20% to 51% depending on preoperative selection criteria and published series [3]. However, up to 75% of resected patients will develop extra- or intrahepatic tumor recurrence [4]. One possible cause for this tumor recurrence may be intraoperative hematogenous tumor cell dissemination due to mechanical manipulation of the tumor during hepatic resection [5].. Recently, RT-PCR based protocols were developed for the detection of disseminated tumor cells [6]. We developed a sensitive and specific CK 20 RT-PCR system for detection of disseminated colorectal cancer cells in blood, bone marrow and lymph nodes [7-9]. By using the CK 20 RT-PCR, we demonstrated that there is a significantly enhanced ...
TY - JOUR. T1 - Expanding the role of surgical therapy for colorectal liver metastases. AU - Choti, Michael A.. PY - 2012/6. Y1 - 2012/6. N2 - Management of patients with colorectal metastases to the liver often requires complex multidisciplinary care. Improved short-term and long-term outcomes with hepatic resection have resulted in an increasing aggressive surgical approach for many of these patients. Even with more contemporary definition of resectability, however, most patients may not be initial candidates for resection. The use of other preoperative systemic and liver-directed therapies offers the opportunity to expand the number of patients who may be candidates for curative-intent strategies. Systemic therapies can achieve responses which are capable of downsizing unresectable disease to a resectable status. Local therapies can also be used in a similar way. Yet, the optimal application and timing of these multimodality approaches to expand the role of surgical therapy remain ...
Liver cancer is not common in the United States.. Liver cancer is the fourth most common cancer and the third leading cause of cancer death in the world. In the United States, men, especially Asian/Pacific Islander men, have an increased risk of liver cancer. The number of new cases of liver cancer and the number of deaths from liver cancer continue to increase, especially among middle-aged black, Hispanic, and white men. People are usually older than 40 years when they develop this cancer. Finding and treating liver cancer early may prevent death from liver cancer. Being infected with certain types of the hepatitis virus can cause hepatitis and increase the risk of liver cancer.. Hepatitis is most commonly caused by the hepatitis virus. Hepatitis is a disease that causes inflammation (swelling) of the liver. Damage to the liver from hepatitis that lasts a long time can increase the risk of liver cancer. There are six types of the hepatitis virus. Hepatitis A (HAV), hepatitis B (HBV), and ...
For more than 20 years, BroadcastMed has been innovating digital strategies for healthcare organizations. The company was first in the world to broadcast live surgeries on the internet using its ORLive solution which provides an intimate look inside the operating room.. ...
On World Cancer Day, the World Hepatitis Alliance is calling for the establishment of comprehensive hepatitis strategies to help prevent the 800,000 liver cancer deaths each year.. London, 4 February 2016 Rock-icon David Bowie died recently at the age of 69 after a battle with what is being reported as liver cancer. Each year, globally, more than 800,000 people die from liver cancer, the second biggest cancer killer.i Yet, a high majority of these deaths are completely preventable.. Liver cancer comes in two forms: primary liver cancer, where it begins in the liver, and secondary, where it spreads from other organs. Primary liver cancer, the most prevalent liver cancer worldwide, can be attributed to heavy drinking and other unhealthy lifestyle choices, but is most commonly caused by having a long-term infection with the hepatitis B or hepatitis C virus - which in turn accounts for the biggest cause of the 642,500 liver cancer related deaths per year, globally.i. What many people dont realise ...
Digital Liver Cancer Summit 2021: New follow-up data from a landmark study of liver cancer patients treated with a combination of an immunotherapy drug (atezolizumab) and a monoclonal antibody (bevacizumab) has shown the longest-ever survival time in a frontline phase 3 trial of systemic therapy in advanced hepatocellular carcinoma (HCC), demonstrating a major breakthrough in the field. The IMbrave150 trial found median overall survival was 19.2 months in patients treated with atezo+bev vs 13.4 months for those treated with sorafenib alone, the current standard treatment (HR, 0.66 [95% CI, 0.52-0.85]; P=0.0009). Survival at 18 months was 52% with atezo+bev and 40% in patients treated with sorafenib.. All patients in the trial had nonresectable HCC - the most common form of liver cancer - and had not previously been treated with systemic therapy. A total of 501 patients were treated in the multicentre, open label, randomised controlled trial and the new follow-up figures confirm the superiority ...
Although variable prognostic factors (patient age, number and size of metastases, lymph node infiltration, stage of primary disease, prior local recurrence of the primary tumor, and clear resection margin of metastatic lesion) have been suggested in some reports, many authors describe the importance of hormone receptor status as a prognostic factor for the primary tumor after complete resection of BCLM [12,17,20]. Golse and Adam [23] suggested that the best results after the resection of BCLM are achieved after applying selection criteria based on small metastases (, 4-5 cm), minor hepatectomy, radical resection (ideally R0, or R1), stable disease after neoadjuvant therapy, and a delay between primary and secondary lesions longer than 1 or 2 years. Howerver, the age of the patient, her hormone receptor status, and HER2 overexpression are not strong predictors of overall survival [23]. In our study, time to recurrence was relatively short if the metastatic lesion was larger than 5 cm, or there ...
October is Liver Cancer Awareness Month. It may be a sleeper of a event when compared to other health campaigns, but for us who live with viral hepatitis, its an uncomfortable but critical reminder of the importance of monitoring our liver health to prevent cancer.. Viral hepatitis, especially B and C, are viral infections that can cause liver cancer (also called hepatocellular carcinoma or HCC.) Researchers are still studying why some people are more prone to liver cancer, but we who live with chronic hepatitis B or C have a 25 to 40 percent lifetime risk of developing liver cancer. The infection, which hijacks our liver cells to manufacture more virus, causes inflammation, scarring and even cancer as the liver cells grow out of control.. The longer we are infected with viral hepatitis, the higher our risk of developing liver cancer. While liver cancer often occurs in people with cirrhosis (severe liver scarring), some of us develop cancer without cirrhosis.. Liver cancer is also a threat to ...
05 Oct 2017. A new article published by JAMA Oncology reports the results of the Global Burden of Disease 2015 study on primary liver cancer incidence, death and years of healthy life lost in 195 countries or territories from 1990 to 2015.. Liver cancer is among the leading causes of cancer death worldwide.. The article by the Global Burden of Disease Liver Cancer Collaboration and corresponding author Christina Fitzmaurice, M.D., M.P.H., of the University of Washington, Seattle, estimates there were 854,000 new cases of liver cancer and 810,000 deaths globally in 2015.. Cases of incident (new) liver cancer increased 75 percent between 1990 and 2015, which was mostly explained by population aging and population growth, according to the authors.. In 2015, hepatitis B virus was the leading cause of new cases of liver cancer, deaths and disability-adjusted life-years (DALYS), which is the sum of years of life lost and years lived with disability such that one DALY can be interpreted as one lost ...
Advances in surgical fields and chemotherapy regimens have been increasing long-term outcomes for patients with Colorectal Liver Metastases (CRLM). The liver resection re..
The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and metastasis is regarded as the major cause of HCC-associated lethality. In this study, we have analysed the TCGA whole-transcriptome sequencing data of paired human HCC samples (n=50), and identified Forkhead Box M1 (FOXM1) and Centromere Protein F (CENPF) to be the top-listing upregulated genes. Interestingly, both of them are the essential components in cell-cycle progression. FOXM1 encodes for the cell-cycle-dependent transcription factor that regulates genes for DNA replication and mitosis, while CENPF encodes for the centromere protein that is required for kinetochore function and chromosome segregation in mitosis.. We hypothesized that the upregulation of FOXM1-CENPF signaling axis may drive hepatocarcinogenesis. In our human HCC cohort (n=34), FOXM1 and CENPF were shown to be upregulated compared with the non-tumorous liver tissues, and their mRNA expressions were positively correlated (p,0.0001). ...
Only a small amount of liver cancers are found early and can be totally removed by surgery. Less that 30 percent of patients are able to have their tumor totally removed. The overall five year survival rate for liver cancer is about 9 percent. One reason for this low number is that many patients with liver cancer have cirrhosis of the liver which could be fatal in itself.. The numbers do sound grim, but not necessarily what will happen, everyone is unique and this cancer can be treated. Surgery, chemotherapy and radiation are used to combat primary liver cancer. One way that liver cancer can be cured is by a liver transplant. This option is for those patients with small liver tumors whos cancer cannot be surgically removed. Over 2500 transplants were performed with people with liver cancer in the last two years. The good news is that the five year survival for these patients was 70 percent.. Some specific treatments available for liver cancer:. ...
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic
The aim of this study was to determine the effect of chemotherapy on the accuracy of CT scan for the preoperative evaluation of colorectal liver metastases (LM). Between 1999 and 2005, 92 patients wit
A minority of patients with colorectal liver metastases and hepatobiliary cancer (primary liver cancer) are candidates for surgery, but there are no curative treatment options for these patients. Their median survival time is 3 to 12 months. Stereotactic radiation (SRT) (highly conformal radiotherapy (CRT)) is a treatment option for these patients with unresectable liver cancer, now possible due to improvements in our ability to localize and immobilize liver tumors and an improved understanding of the partial liver volume tolerance to radiation. SRT should permit liver tumors to be treated to tumorcidal doses while sparing the uninvolved liver, decreasing the risk of treatment related normal tissue toxicity. With such conformal radiation, it is possible to deliver radiation in fewer fractions than traditionally required, which should be more convenient for patients. In this study, CRT will be delivered during shallow breathing or breath hold to minimize organ motion due to breathing, decreasing ...
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US Pharm. 2016;41(12):HS-20.. Reoviruses, which cause childhood coughs and colds, could help in the fight against primary liver cancer, according to a study by University of Leeds researchers in England. The reovirus, say the scientists, is also able to kill the hepatitis C virus, which is a common cause of primary liver cancer and the third highest cause of cancer deaths worldwide.. Study coleader Dr. Stephen Griffin, associate professor of viral oncology at the University of Leeds, said, Ultimately we hope that by simultaneously treating the tumour, and the hepatitis virus that is driving the growth of the tumour, we may provide a more effective therapy and improve the outcomes for patients.. The University of Leeds team found that reovirus was successful against liver cancer cells grown in the laboratory as well as those collected from patients undergoing surgery. The study results were published in the journal Gut.. ...
Liver metastasis occurs when cancerous tumor cells spread to the liver from another part of the body. – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 88e988-NzRlM
BMI, WC, and type II diabetes mellitus were associated with higher risks of liver cancer in this prospective analysis of 1.57 million participants enrolled in 14 U.S.-based cohort studies. Higher BMI was associated with liver cancer in a dose-response manner, and associations were robust after controlling for smoking, alcohol intake, and other risk factors. High WC was associated with higher risks of liver cancer, and these associations were attenuated after including BMI in the statistical models, suggesting shared effects of both BMI and WC on liver cancer risk, perhaps owing to these phenotypes being correlated with visceral adiposity. Type II diabetes mellitus was a strong predictor of liver cancer risk, and these results were robust even at nonobese BMI levels and after controlling for their shared risk factors. Some evidence of heterogeneity was detected across studies when sensitivity analyses were conducted in individual participant meta-analyses, which seemed to be the result of our ...
Dublin, May 17, 2021 (GLOBE NEWSWIRE) -- The Global Liver Cancer Hepatoma Epidemiology and Patient Flow - 2021 report has been added to ResearchAndMarkets.coms offering. Global Liver Cancer Hepatoma Epidemiology and Patient Flow Analysis - 2021, provides Liver Cancer Hepatoma epidemiology, demographics, and patient flow. The data is presented by Pharma G7 countries including the US, France, Spain, Italy, UK, Japan.The research provides population data to characterize Liver Cancer Hepatoma patients, history of the disease at the population level (Liver Cancer Hepatoma prevalence, Liver Cancer Hepatoma incidence) and at the clinical level (from diagnosis to treated patients). It also helps to identify patient sub-groups (age, gender, sub-groups) to understand targeted population for research and development, commercialization.Research scope: Liver Cancer Hepatoma patient flow: Liver Cancer Hepatoma prevalence, diagnosed, and drug-treated patientsCountries: US, Germany, France, Italy, Spain, UK, Japan,
Research should document indications for treatment, details of patient selection and details of adjuvant and prior treatments. Outcome measures should include complications, survival and quality of life. Data from welldesigned trials comparing the procedure against other forms of management would be particularly useful, but prospective observational studies may also be of value ...
Pfizer is currently recruiting for the NCT00106054 Colorectal Neoplasms, Liver Neoplasms Cancer trial. Review trial description, criteria and location information here.
Even after a functional cure for hepatitis B is achieved, the risk for hepatocellular carcinoma persists in older patients, new research warns. Medscape Medical News
초록. Liver resection is the only curative treatment for patients with colorectal liver metastases (CLMs). Neoadjuvant chemotherapy can improve resectability but has a potential harmful effect on the nontumorous liver. Patients with chemotherapy-induced hepatic injury undergoing liver surgery have higher risks of post-resectional morbidity. We present two cases of patients without pre-existent liver disease treated with oxaliplatin-based chemotherapy followed by surgical resection of their CLMs. Their intra-operative liver specimen showed morphologic abnormalities characteristic of nodular regenerative hyperplasia (NRH). NRH led to portal hypertension in both patients that resulted in deleterious post-resectional complications and death of one patient. Interestingly, the other patient underwent two repeat nonanatomic liver resections because of recurrent CLMs. The intra-operative liver specimen still showed signs of NRH and sinusoidal congestion, but the post-resectional courses were ...
Fibrolamellar hepatocellular carcinoma (FLC) is a rare subtype of primary liver cancer. Fibrolamellar hepatocellular carcinoma was first described Edmondson in 1956.[1][2] Fibrolamellar hepatocellular carcinoma is most commonly seen in children and young adults. The pathogenesis of fibrolamellar hepatocellular carcinoma is characterized by the lack of cirrhosis. Common causes of fibrolamellar hepatocellular carcinoma, include: active hepatic inflammation, hepatitis B or C viral infection, alcohol-related liver disease, nonalcoholic fatty liver disease, and dietary aflatoxin B1. The majority of patients with fibrolamellar hepatocellular carcinoma remain asymptomatic for years. Early clinical features include abdominal pain, weight loss, and malaise. If left untreated, the majority of patients with fibrolamellar hepatocellular carcinoma may progress to develop metastasis to abdominal lymph nodes, peritoneum, and lung. Common complications of fibrolamellar hepatocellular carcinoma include: hepatic ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Metastatic Hepatocellular Carcinoma (HCC) market report covers research informatics related to Metastatic Hepatocellular Carcinoma (HCC) clinical trials, such as a listing of industry and sponsored clinical trials as well as new drug therapies.. Designed to be a resource both for patients interested in participating in Metastatic Hepatocellular Carcinoma (HCC) clinical trials and for research professionals.. The report, Metastatic Hepatocellular Carcinoma (HCC) Global Clinical Trials Review, H2, 2016″ provides an overview of Metastatic Hepatocellular Carcinoma (HCC) clinical trials scenario. This report provides top line data relating to the clinical trials on Metastatic Hepatocellular Carcinoma (HCC). Report includes an overview of trial numbers and their average enrolment in top countries conducted across the globe. The report also offers coverage of disease clinical trials by region, country (G7 & E7), ...
TY - JOUR. T1 - First-time use of bevacizumab for aggressive, metastatic hepatocellular carcinoma in an HIV/hepatitis B virus coinfected patient. T2 - A case report. AU - Baraboutis, Ioannis G.. AU - Papastamopoulos, Vassilios. AU - Charitsis, Georgios. AU - Lekakis, Lazaros J.. AU - Vaslamatzis, Michael M.. AU - Skoutelis, Athanasios T.. PY - 2008/5/1. Y1 - 2008/5/1. N2 - We present a case of an HIV-1 infected patient with history of chronic hepatitis B and chronic alcohol use without cirrhosis, who presented with aggressive hepatocellular carcinoma with multiple metastases. Systemic chemotherapy combined with use of bevacizumab (anti-vascular endothelium growth factor monoclonal antibody) was without effect and the patient succumbed to his disease within few weeks. To our knowledge, this is the first report in the English literature of bevacizumab use for metastatic hepatocellular carcinoma in HIV-infected patients.. AB - We present a case of an HIV-1 infected patient with history of chronic ...
BACKGROUND AND AIM: Patients with persistently active hepatitis B virus (HBV) replication are at high risk for progression to liver cirrhosis and hepatocellular carcinoma (HCC). The influence of the viral load of HBV on intrahepatic recurrence after local ablation therapy in patients with HBV-related HCC has not been elucidated. We aimed to evaluate predictors of intrahepatic recurrence and clarify the correlation between viral load and intrahepatic recurrence after percutaneous ablation.. METHODS: Patients with HBV-related, solitary HCC undergoing radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI), between October 2004 and December 2008 were prospectively enrolled. Statistical analyses were performed using the Kaplan-Meier method and Cox regression model to identify risk factors for intrahepatic recurrence.. RESULTS: A total of 145 patients (male, 81.4%; mean age, 55.3 years) were included. Ninety patients (62.1%) had serum HBV DNA ≥2000 IU/mL. The median follow-up duration ...
Gehring, A.J., Ho, Z.Z., Tan, A.T., Bertoletti, A., Aung, M.O., Lim, S.G., Lee, K.H., Tan, K.C., Lim, S.G. (2009). Profile of Tumor Antigen-Specific CD8 T Cells in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma. Gastroenterology 137 (2) : 682-690. [email protected] Repository. https://doi.org/10.1053/j.gastro.2009.04. ...
On May 29, 2020, the FDA approved the immunotherapy atezolizumab (Tecentriq; Genentech), a PD-L1 inhibitor, in combination with bevacizumab (Avastin; Genentech), a vascular endothelial growth factor inhibitor, for the treatment of patients with unresectable or metastatic hepatocellular carcinoma (HCC) who have not received systemic therapy. This is the first immunotherapy regimen approved by the FDA for this type of HCC.
Fibrolamellar hepatocellular carcinoma (FHCC) is a rare form of hepatocellular carcinoma (HCC) that typically affects young adults and is characterized, under the microscope, by laminated fibrous layers interspersed between the tumour cells. Approximately 200 new cases are diagnosed worldwide each year. A recent study showed the presence of the DNAJB1-PRKACA chimeric transcript (resulting from a 400kb somatic deletion on chromosome 19) in 100% of the FHCCs examined (15/15) This gene fusion has been confirmed in a second study. The histopathology of FHCC is characterized by laminated fibrous layers, interspersed between the tumor cells. Cytologically, the tumor cells have a low nuclear to cytoplasmic ratio with abundant eosinophilic cytoplasm. Tumors are non-encapsulated, but well circumscribed, when compared to conventional HCC (which typically has an invasive border). Due to lack of symptoms, until the tumor is sizable, this form of cancer is often advanced when diagnosed. Symptoms include ...
TY - JOUR. T1 - Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics. AU - Lin, Chien Hua. AU - Hsieh, Ming Ju. AU - Lee, Hsiang Lin. AU - Yang, Shun Fa. AU - Su, Shih Chi. AU - Lee, Wei Jiunn. AU - Chou, Ying Erh. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathological characteristics. In this study, real-time polymerase chain reaction was applied to analyze five SNPs of MACC1 rs1990172, rs975263, rs3095007, rs4721888, and rs3735615 in 378 patients with HCC and 1199 cancer-free controls. The results showed that in 151 HCC patients among smokers who carried MACC1 rs1990172 CA + AA variants had a lower risk of developing a large tumor (odds ratio [OR] = ...
To the editor: We are writing in response to the letter (1) on fibrolamellar hepatocellular carcinoma, in which Ruffin points out that the cases of this tumor reported since 1941 have all originated in the United States. We report two cases of this tumor diagnosed in patients treated at our hospital.. A 25-year-old man was hospitalized for epigastric discomfort; anorexia was present for 5 months. Physical examination showed a liver edge 12 cm below the right costal margin. The erythrocyte sedimentation rate was 135 mm/h; alkaline phosphatase, 100 U/L (normal, ≤ 40 U/L); and gamma-glutamyltransferase, 89 IU/L (normal, ≤ 30 ...
Dynamic monitoring of serum alpha-fetoprotein and its correlation with early hepatocellular carcinoma in patients with chronic hepatitis B, Qing-Feng Chen, Xiao-Min Luo, Mei-Ping Z
TY - JOUR. T1 - A single institute retrospective trial of concurrent chemotherapy with SIR-Spheres® versus SIR-Spheres® alone in chemotherapyresistant colorectal cancer liver metastases. AU - Cho, May. AU - Kessler, Jonathan. AU - Park, John J.. AU - Lee, Aram. AU - Gong, Jun. AU - Singh, Gagandeep. AU - Chen, Yi Jen. AU - Ituarte, Philip H.G.. AU - Fakih, Marwan. PY - 2017/8/1. Y1 - 2017/8/1. N2 - Background: The use of selective internal radiation therapy with yttrium 90 resin microspheres (SIRSpheres ®) in chemotherapy-resistant colorectal cancer liver metastases has been associated with favorable progression-free survival (PFS) and overall survival when given alone or concurrently with chemotherapy. We conducted a single institute retrospective trial to explore the potential impact of SIR-Spheres® with concurrent chemotherapy vs. SIR-Spheres® alone on liver PFS in patients with colorectal liver metastases (CRLM). Methods: Patients with 5-fluorouracil-refractory CRLM treated with ...
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HCC is the third most common cancer worldwide, causing about 700,000 deaths annually.2 It is associated with cirrhosis, hepatitis B and C virus, primary biliary and sclerosing cholangitis, aflatoxins, and autoimmune hepatitis.2,3 Extrahepatic metastatic HCC, as observed in this case, occur in 30-50% of HCC patients; the most common sites are lungs, bones, adrenal glands, and lymph nodes.4 Rare and unusual metastatic sites have been described in the literature, including the chest wall presenting as a breast mass and metastasis to the nasal septum.5,6 Indeed, extrahepatic metastases to the humeral shoulder, chest wall, and bony lesions are exceedingly rare, as only a handful of cases have been reported.3,7 Traditionally, a few systems have been widely employed for HCC staging (e.g. Okuda, tumor/node/metastasis), however, newer classification systems that take into account prognostication and treatment regimens are increasingly being utilized.8 The Cancer of the Liver Italian Program (CLIP) and ...
RESULTS: Seven patients (median age 21 years, range 19 - 42, 5 men, 2 women) underwent surgery for FLC. No patient had underlying liver disease or an elevated alpha feto-protein (AFP) at either initial presentation or recurrence. Six patients had a solitary tumour at diagnosis (mean largest diameter = 12cm), and underwent left hepatectomy (N=2), right hepatectomy (N=1), extended right hepatectomy (N=1), and segmentectomies (N=2). Three patients underwent a portal lymphadenectomy for regional lymphatic tumour involvement. One patient with advanced extrahepatic portal nodal metastasis was unresectable. No peri-operative deaths occurred. Recurrence occurred post resection in all 6 patients. Median overall survival was 60 months, and overall 5-year survival was 4 out of 7 (57%). Post-resection survival (N=6) was 61 months, with a 5-year survival rate of 4 out of 6 (67%). The patient with unresectable disease survived 38 months after tumour embolisation with Lipiodol ...
Two firsts in studies of colorectal liver metastases were highlighted at the 2015 ASCO Annual Meeting: the first prospective randomized trial to evaluate radiofrequency ablation plus chemotherapy1 and the first large randomized phase III trial to study liver-directed selective internal radiation therapy.2 Radiofrequency ablation plus chemotherapy appeared to have clear benefit in this setting, whereas the results for selective internal radiotherapy in first-line therapy are currently less conclusive. Daniel G. Haller, MD, of Abramson Cancer Center at the University of Pennsylvania, discussed both trials at Best of ASCO® 2015 in Boston.. Radiofrequency Ablation Plus Chemotherapy. Unresectable liver metastases treated with radiofrequency ablation plus chemotherapy improved long-term overall and progression-free survival compared with chemotherapy alone in patients with metastatic colorectal cancer, according to the results of the randomized phase II study of the EORTC NCRI CCSG-ALM Intergroup ...
TY - JOUR. T1 - Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases. AU - Yamashita, Yo Ichi. AU - Adachi, Eisuke. AU - Toh, Yasushi. AU - Ohgaki, Kippei. AU - Ikeda, Osamu. AU - Oki, Eiji. AU - Minami, Kazuhito. AU - Sakaguchi, Yoshihisa. AU - Tsujita, Eiji. AU - Okamura, Takeshi. PY - 2011/4/1. Y1 - 2011/4/1. N2 - Purpose. With the broadening indications for hepatectomy to treat colorectal liver metastases (CRLM), early recurrence is a major problem. The aim of this study is to identify risk factors of early recurrence, defi ned as recurrence within 1 year after surgery. Methods. A retrospective analysis was performed on 121 consecutive patients who underwent hepatectomy for CRLM. Results. Among 121 patients, 52 (43.0%) developed early recurrence. The independent risk factor for early recurrence was number of liver metastases ≥3 (odds ratio 2.65). There were signifi cantly more patients with liver recurrence (51.9%) and recurrence beyond curative ...
Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC);however, the development of chemoresistance in liver cancer cells usually results in a relapse and worseningof prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles inchemotherapy resistance. Currently, extensive research has shown that there is another potential mechanismof gene expression control, which is mediated through the function of short noncoding RNAs, especially formicroRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, bytaking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, ithas been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays ofNrf2-3-untranslated region-based reporter constructor
Hepatitis C virus (HCV) infection causes chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma (HCC). The incidence of hepatocellular carcinoma in the United States tripled between 1975 and 2005, and is expected to increase further, and to remain elevated for more than 20 years. Curing hepatitis C infection in patients with cirrhosis through treatment with peginterferon and ribavirin reduces the risk of developing hepatocellular carcinoma. Several noncurative treatments also appear to reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis C. Prospective studies report a reduced incidence of hepatocellular carcinoma among patients treated with a mixture of carotenoids with or without myo-inositol, with vitamin K(2), or with polyprenoic acid (an acyclic retinoid). Uncontrolled and/or retrospective studies have reported beneficial effects of treatment with Sho-saiko-to, glycyrrhizin and ursodeoxycholic acid on hepatocellular carcinoma incidence. ...
TY - JOUR. T1 - Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells. AU - Kim, Seung Hun. AU - Wang, Wen Hsing. AU - Wang, Jing Ping. AU - Hsieh, Chang Heng. AU - Fang, Kang. PY - 2018/3. Y1 - 2018/3. N2 - Aims: The prevalent human hepatocellular carcinoma (HCC) is a leading cause of global cancer-related mortality. The small molecular weight triepoxide derivative, 1,3,5-triazine-2,4,6(1H,3H,5H)-tri-one-1,3,5-tri-(oxiranylmethyl) (teroxirone), has been proved effective against the proliferation of lung cancer cells. The purpose is to further examine if teroxirone regulate growth and metastatic potential of HCC cells with aims at disclosing more of the reaction mechanisms. Main methods: Measurements of cell viability and flow cytometry were conducted to test sensitivities of teroxirone against HCC cells. The signaling pathway leading to apoptotic death was unraveled by Western blotting analysis. The metastatic progression was evaluated by cell-based phenotype assay ...
Neovascularization provides the route for nutrient supply to the tumor and the conduit for tumor cells to be shed into the circulation. CD31 is a pan-endothelial cell marker and CD105 is an active endothelial cell marker, but whether there is a link between CD105 expression and metastasis in Hepatocellular carcinoma (HCC) still remains unclear. A tissue microarray containing 38 HCCs and adjacent non-tumorous liver tissue samples was constructed. The microvessel density (MVD) of CD31, CD105, vWF and the expression of PCNA, VEGF were investigated in a HCC tissue microarray by immunohistochemistry. There was a significant difference between the score of MVD-CD31 in HCC (48.5 ± 29.7) and non-tumorous liver tissue (24.2 ± 22.3, P|0.01). The mean score of MVD-CD31 was higher in HCCs with high PCNA expression (68.4 ± 37.0) than in HCCs with low PCNA expression (37.9 ± 30.9, P = 0.012). MVD-CD105 and VEGF expression were significantly higher in HCC with intrahepatic metastasis (P | 0.01). Multivariate
TY - JOUR. T1 - Recurrent hepatocellular carcinoma after liver transplant. T2 - Identifying the high-risk patient. AU - Nissen, Nicholas N.. AU - Menon, Vijay. AU - Bresee, Catherine. AU - Tran, Tram T.. AU - Annamalai, Alagappan. AU - Poordad, Fred. AU - Fair, Jeffrey H.. AU - Klein, Andrew S.. AU - Boland, Brendan. AU - Colquhoun, Steven D. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Background: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is rarely curable. However, in view of the advent of new treatments, it is critical that patients at high risk for recurrence are identified. Methods: Patients undergoing LT for HCC at a single centre between 2002 and 2010 were reviewed and data on clinical parameters and explant pathology were analysed to determine factors associated with HCC recurrence. All necrotic and viable tumour nodules were included in explant staging. All patients underwent LT according to the United Network for Organ Sharing (UNOS) Model for End-stage Liver ...
In the present study, serotonin 2C (5-HT2c) receptor binding parameters in the brainstem and cerebral cortex were investigated during liver generation after partial hepatectomy (PH) and N-nitrosodiethylamine (NDEA) induced hepatic neoplasia in male Wistar rats. The serotonin content increased significantly (p,0.01) in the cerebral cortex after PH and in NDEA induced hepatic neoplasia. Brain stem serotonin content increased significantly (p,0.05) after PH and (p,0.001) in NDEA induced hepatic neoplasia. The number and affinity of the 5-HT2c receptors in the crude synaptic membrane preparations of the brain stem showed a significant (p,0.001) increase after PH and in NDEA induced hepatic neoplasia. The number and affinity of 5-HT2c receptors increased significantly (p,0.001) in NDEA induced hepatic neoplasia in the crude synaptic membrane preparations of the cerebral cortex. There was a significant (p,0.01) increase in plasma norepinephrine in PH and (p,0.001) in NDEA induced hepatic neoplasia, ...
It has been estimated that 70% to 90% of patients with hepatocellular carcinomas have an established background of chronic liver disease or cirrhosis, the major causes of which are HBV or HCV infection (26, 27). More than 50% (340,000 cases) of all hepatocellular carcinomas worldwide are associated with HBV infection and near 30% (195,000 cases) are HCV infection-related (28, 29). Once cirrhosis is established, the annual risk of developing hepatocellular carcinoma is estimated to be as high as 3% to 4% (30). Screening for hepatocellular carcinoma using serum AFP or combined with ultrasonography in these high-risk populations is still the essential way for detection and diagnosis of hepatocellular carcinomas at an earlier stage, when curative therapies are likely to be more successful (31, 32).. On the basis of the specific screening requirements for hepatocellular carcinomas in the context of chronic liver disease and cirrhosis and the general criteria for an adequate screening test to detect ...
Reference list:. Moulton C-A, Gu C-S, Law CH, Tandan VR, Hart R, Quan D, et al. Effect of PET Before Liver Resection on Surgical Management for Colorectal Adenocarcinoma Metastases: A Randomized Clinical Trial. JAMA. 2014;311(18):1863-9.. Bahadoer RR, Dijkstra EA, Etten B van, Marijnen CAM, Putter H, Kranenbarg EM-K, et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(1):29-42.. ...
TY - JOUR. T1 - Lipocalin-2 Induces Apoptosis in Human Hepatocellular Carcinoma Cells Through Activation of Mitochondria Pathways. AU - Chien, Ming Hsien. AU - Ying, Tsung Ho. AU - Yang, Shun Fa. AU - Yu, Ji Kuen. AU - Hsu, Chih Wei. AU - Hsieh, Shu Ching. AU - Hsieh, Yi Hsien. PY - 2012. Y1 - 2012. N2 - Lipocalin 2 (LCN2) is a secreted, iron-binding glycoprotein that is abnormally expressed in some malignant human cancers. However, the roles of LCN2 in hepatocellular carcinoma (HCC) cells are unknown. In this study, we suggested the LCN2 and LCN2R were weak detected in the HCC cell lines, LCN2 and LCN2R were found to be down-regulated in tumor tissues in 16 HCC patients. MTT, DAPI, TUNEL, and flow cytometry analyses revealed that LCN2 overexpression dramatically inhibited cell viability, induced apoptosis features of cell-cycle arrest in sub-G1 phase, in DNA fragmentation, and in condensation of chromatin in Huh-7 and SK-Hep-1 cells. Western blots were used to detect the activation of caspase, ...
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The liver is the most common anatomical site for hematogenous metastases from colorectal cancer. Therefore effective treatment of liver metastases is one of the most challenging elements in the management of colorectal cancer. However, there is rare available clinical consensus or guideline only focusing on colorectal liver metastases. After six rounds of discussion by 195 clinical experts of the Shanghai International Consensus Expert Group on Colorectal Liver Metastases (SINCE) from 29 countries or regions, the Shanghai Consensus has been finally completed, based on current research and expert experience. The consensus emphasized the principle of multidisciplinary team, provided detailed diagnosis approaches, and guided precise local and systemic treatments. This Shanghai Consensus might be of great significance to standardized diagnosis and treatment of colorectal liver metastases all over the world.
Purpose: Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) carries a poor prognosis. We aimed to develop a risk score for early HCC recurrence using pre-LT variables.. *Methods: Adults undergoing LT for HCC from 2001-2015 from 6 large centers were reviewed. Competing risk regression was used to identify predictors of early HCC recurrence (≤ 1 year).. *Results: Of 3235 patients, 459 developed HCC recurrence (14.2%), including 175 (38%) recurrences within 1 year of LT. Independent pre-LT predictors of early HCC recurrence included initial tumor size > 3 cm, ≥ 3 pre-LT locoregional therapies, pre-LT neutrophil-to-lymphoycte ratio > 5, and alpha-fetoprotein response. The early recurrence risk score was created using hazard ratios and resulted in low (0 points), low-medium (2-4 points), medium-high (5-8 points), and high (>8 points) risk groups (Fig 1). The probability of recurrence at 1-year in the low-risk group was 1.8% vs. 44.9% in the high-risk group ( ...
To evaluate the clinical efficacy of interferon-α in hepatocellular carcinoma, 71 adult Chinese patients with histologically proven inoperable hepatocellular carcinoma were randomized to receive recombinant interferon- α(2a) (50 x 106 IU/m2) intramuscularly three times a week (n = 35) or no antitumor therapy (n = 36). The survival of interferon-α-treated patients was significantly better than that of patients who received no antitumor therapy (p = 0.0471); median lengths of survival were 14.5 and 7.5 wk, respectively. Objective tumor regression greater than 50% was observed in 31.4% (11 of 35) of patients receiving interferon-α. Interferon-α induced tumor regression greater than 50% in 11 (31.4%) patients. Compared with the group receiving no antitumor therapy, the interferon-α therapy group had more tumor regression (p < 0.0001) and less tumor progression (p = 0.001). This high-dose interferon-α therapy was relatively well tolerated; only 34.3% of patients required reduction of dosage by ...
JNK proteins have been shown to be involved in liver carcinogenesis in mice, but the extent of their involvement in the development of human liver cancers is unknown. Here, we show that activation of JNK1 but not JNK2 was increased in human primary hepatocellular carcinomas (HCCs). Further, JNK1 was required for human HCC cell proliferation in vitro and tumorigenesis after xenotransplantation. Importantly, mice lacking JNK1 displayed decreased tumor cell proliferation in a mouse model of liver carcinogenesis and decreased hepatocyte proliferation in a mouse model of liver regeneration. In both cases, impaired proliferation was caused by increased expression of p21, a cell-cycle inhibitor, and reduced expression of c-Myc, a negative regulator of p21. Genetic inactivation of p21 in JNK1-/- mice restored hepatocyte proliferation in models of both liver carcinogenesis and liver regeneration, and overexpression of c-Myc increased proliferation of JNK1-/- liver cells. Similarly, JNK1 was found to control the
Sigma-Aldrich offers abstracts and full-text articles by [Gek San Tan, Kiat Hon Lim, Hwee Tong Tan, May Lee Khoo, Sze Huey Tan, Han Chong Toh, Maxey Ching Ming Chung].
TY - JOUR. T1 - Treatment strategies for locally advanced rectal cancer with synchronous resectable liver metastasis. AU - Park, Youn Young. AU - Kim, Namkyu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Approximately one-third of patients with colorectal cancer are estimated to be diagnosed with synchronous liver metastasis (LM). The only method to get cured is to achieve curative resection for both primary and LM. When it comes to locally advanced rectal cancer with synchronous LM, determination of the treatment strategy for each individual is a quite complex procedure, because it demands sophisticated consideration for both local and systemic control. Timing for the application of systemic chemotherapy (CTx), determination of a chemotherapeutic agent, radiation dose and fractions, and sequencing of preoperative treatment and surgeries are all essential components for establishing optimal treatment strategies for the patients with this disease. In this article, treatment strategies proposed in the ...
Cell culture. Human hepatocellular carcinoma cell line (Hep3B), human colorectal carcinoma cell line (SW620), and human normal lung fibroblast cell lines (NHLF and MRC5) were obtained from the American Type Culture Collection. Human hepatocellular carcinoma cell lines (BEL7404 and SMMC7721) and human normal liver cell lines (QSG7701 and L-02) were purchased from the Shanghai Cell Collection. HEK293 was obtained from Microbix Biosystems, Inc. Cells were maintained in humidified 37°C atmosphere containing 5% CO2 and cultured in DMEM (Life Technologies) supplemented with 10% heat-inactivated fetal bovine serum (Life Technologies), 4 mmol/L glutamine, 50 units/mL penicillin, and 50 μg/mL streptomycin.. Virus construction and production. The constructs including pCN205-EGFP and pCN205-IL-24 were generated according to the standard molecular cloning protocol. The homologous recombination between pCN205-EGFP and pCN205-IL-24 plasmids and pCN103 plasmid carrying oncolytic adenoviral backbone was done ...
CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor antigens
Currently in Japan, HCV infection is the most common background liver disease of HCC, followed by HBV infection and alcoholic liver disease. Primary biliary cirrhosis and other chronic liver diseases are an uncommon cause of HCC. The underlying liver disease in the remaining HCC cases, constituting about 5% of the total, is usually not determined, with histological examination revealing only cryptogenic cirrhosis. NASH is thought to be responsible for a substantial portion of such HCC cases, but characteristic pathology is rarely present at the stage of HCC development.. HCC is characterised by extremely frequent intrahepatic recurrence even after successful curative treatments.24 Both surgical hepatectomy and medical ablation are locoregional treatment in that the background liver diseases are left untreated. Liver transplantation forms an exception, after which recurrence is rare if the indication is appropriate. Two modes of intrahepatic recurrence have been distinguished: de novo ...
Clinical trial for HEPATIC NEOPLASM | HEPATOCELLULAR CARCINOMA , A Study of Nivolumab in Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
Clinical trial for HEPATIC NEOPLASM | HEPATOCELLULAR CARCINOMA , A Study of Nivolumab in Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
BACKGROUND: Sorafenib is the recommended treatment for patients with advanced hepatocellular carcinoma. We aimed to compare the efficacy and safety of sorafenib to that of selective internal radiotherapy (SIRT) with yttrium-90 ((90)Y) resin microspheres in patients with hepatocellular carcinoma. METHODS: SARAH was a multicentre, open-label, randomised, controlled, investigator-initiated, phase 3 trial done at 25 centres specialising in liver diseases in France. Patients were eligible if they were aged at least 18 years with a life expectancy greater than 3 months, had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, Child-Pugh liver function class A or B score of 7 or lower, and locally advanced hepatocellular carcinoma (Barcelona Clinic Liver Cancer [BCLC] stage C), or new hepatocellular carcinoma not eligible for surgical resection, liver transplantation, or thermal ablation after a previously cured hepatocellular carcinoma (cured by surgery or thermoablative ...
A new study published in the Journal of the National Cancer Institute concluded that high consumption of vitamin E from diet or supplements may lower the risk of liver cancer. Although we rarely hear about liver cancer, it is the third most common cause of cancer mortality in the world and a large percentage of these occurs in developing countries.. Data was analyzed from 132,737 people in China who were enrolled in the Shanghai Womens Health Study from 1997 to 2000, or the Shanghai Mens Health Study from 2002 to 2006.. In-person interviews to gather data on dietary habits were conducted using validated food-frequency questionaires. Questions were included on how often participants ate some of the most commonly consumed Shanghai foods and whether or not they took vitamin supplements. Liver cancer risk was then determined between those with high and low vitamin E intake.. There were 267 liver cancer patients (118 women and 149 men) diagnosed between 2 years after study enrollment and an average ...
Fibrolamellar hepatocellular carcinoma (FL-HCC) is generally a fairly rare event in routine pathology practice. This variant of hepatocellular carcinoma (HCC) is peculiarly intriguing and,in addition, poorly understood. Young people or children are often the target individuals with this type of cancer. Previously, I highlighted some pathology aspects of FL-HCC, but in this review, the distinctive clinico-pathologic features of FL-HCC and the diagnostic pathologic criteria of FL-HCC are fractionally reviewed and expanded upon. Further, molecular genetics update data with reference to this specific tumor are particularly highlighted as a primer for general pathologists and pediatric histopathologists. FL-HCC may present with metastases, and regional lymph nodes may be sites of metastatic spread. However, peritoneal and pulmonary metastatic foci have also been reported. To the best of our knowledge, FL-HCC was initially considered having an indolent course, but survival outcomes have recently been updated
Liver Cancer (hepatocellular carcinoma). Medical Term: None Specified. Description:. A malignant tumor arising from liver cells. Although much less common than metastatic liver cancer in most areas of the world, hepatocellular carcinoma is the most common internal malignancy and an important cause of death in certain areas of Africa and Southeast Asia. This is mainly because of the high incidence of Hepatitis B in these areas.. In North America, hepatocellular carcinoma is mainly associated with cirrhosis of the liver.. Causes: Unknown. As noted above, there is a high association with Hepatitis B and C, and cirrhosis of liver.. Prevention: Hepatitis B vaccination and prevention education for high-risk individuals. Minimize alcohol use.. Signs & Symptoms. ...
TY - JOUR. T1 - Surgical Resection vs. Ablative Therapies Through a Laparoscopic Approach for Hepatocellular Carcinoma: a Comparative Study. AU - Santambrogio, Roberto. AU - Santambrogio, Roberto. AU - Barabino, Matteo. AU - Bruno, Savino. AU - Mariani, Nicolò. AU - Maroni, Nirvana. AU - Bertolini, Emanuela. AU - Franceschelli, Giuseppe. AU - Opocher, Enrico. PY - 2017/12/12. Y1 - 2017/12/12. N2 - © 2017 The Society for Surgery of the Alimentary Tract Background: When compatible with the liver functional reserve, laparoscopic hepatic resection remains the treatment of choice for hepatocellular carcinoma while laparoscopic ablation therapies appear as a promising less invasive alternative. The aim of the study is to compare two homogeneous groups of patients submitted to either hepatic resection or thermoablation for the treatment of single hepatocellular carcinoma (≤ 3 cm). Methods: We enrolled 264 cirrhotic patients out of 905 cases consecutively evaluated for hepatocellular carcinoma. We ...
Objective: To investigate the prognostic relationship between the expression levels of periostin (POSTN) in hepatocellular carcinoma (HCC) tissues as well as its effect in invasion and metastasis. Methods: The expression levels of POSTN in liver cancer tissues were detected with real-time quantitative PCR (QPCR) and immunohistochemistry (IHC). Kaplan-Meier method and Log-rank test were used to analyze the relationship between POSTN expression level and postoperative prognosis in patients with liver cancer. The expression of POSTN in hepatocellular carcinoma cells with different metastasis characteristics were detected in vitro and the overexpression of POSTN in low metastatic hepatocellular carcinoma cells was mediated through plasmid transfection techniques. The effects of POSTN on invasion and metastasis of hepatocellular carcinoma cells were determined by transwell migration and matrigel invasion assay. The comparative expression level of POSTN was analyzed by t-test. Results: The expression ...
Abdominal ultrasonograms are often obtained for the initial evaluation of patients with abdominal pain; therefore, ultrasonography may be the first imaging study available in patients with fibrolamell... more
Breedis C, Young G (September-October 1954). "The blood supply of neoplasms in the liver". The American Journal of Pathology. ... Liver metastases get most of their blood supply primarily from the hepatic artery, whereas the normal liver cells get their ... Patients undergoing HAI therapy therefore have regular liver function tests to monitor any damage to the liver. As previously ... The liver derives its blood supply from two sources - via the hepatic arterial circulation and the portal circulation. ...
Shi J, Zhang Y, Gu W, Cui B, Xu M, Yan Q, Wang W, Ning G, Hong J (2012-11-07). "Serum liver fatty acid binding protein levels ... a marker for studying cellular differentiation in gut epithelial neoplasms". Gastroenterology. 99 (6): 1727-35. PMID 1699834. ... Chan L, Wei CF, Li WH, Yang CY, Ratner P, Pownall H, Gotto AM, Smith LC (March 1985). "Human liver fatty acid binding protein ... Mishkin S, Turcotte R (April 1974). "The binding of long chain fatty acid CoA to Z, a cytoplasmic protein present in liver and ...
liver neoplasm (en) , hepatobiliary system cancer (en) endocrine gland cancer (en) Espezialitatea. onkologia. ...
"ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms ... Use of liver transplantation may be considered in certain cases of liver metastasis.[81] ... "Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Liver function tests can show a combination of results indicative of bile duct obstruction (raised conjugated bilirubin, γ- ...
... liver diseases, neoplasms, cystic fibrosis and celiac disease". European Journal of Pediatrics. 129 (1): 29-35. doi:10.1007/ ...
Breedis C, Young G (October 1954). "The blood supply of neoplasms in the liver". The American Journal of Pathology. 30 (5): 969 ... Patients with underlying liver disease require a greater volume of liver remnant to maintain hepatic function, thus, tumors ... The majority of patients with HCC have underlying liver disease with resultant cirrhosis. Patients with normal liver function ... embolization of a hemi-liver in a Child A patient with multifocal hepatoma involving more than 75% of the liver and with portal ...
The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the ... on liver cancer Video showing laprascopic liver resection. The Toronto Video Atlas of Liver, Pancreas and Transplant Surgery - ... While the term is often employed for the removal of the liver from a liver transplant donor, this article will focus on partial ... These procedures can also be aided by application of liver clamp (Lin or Chu liver clamp; Pilling no.604113-61995) in order to ...
... liver disease, and malignant neoplasms. The psychiatric disorders which are associated with alcoholism include major depression ... Typically the liver eliminates 99% of acetaldehyde produced. However, liver disease and certain genetic enzyme deficiencies ... In cases of severe liver disease, the only treatment option may be a liver transplant from alcohol abstinent donors. Research ... liver, breast and ovaries. Heavy drinking is associated with liver disease, such as cirrhosis. Excessive alcohol consumption ...
Endocrine gland cancer, clefyd yr afu, rare hepatic and biliary tract tumor, liver neoplasm, hepatobiliary system cancer ... Ceir rhai llai cyffredin yn ogystal, er enghraifft neoplasm systig mwsinog a neoplasm bustlaidd papilaidd anhydradwyol. Gellir ... www.cancer.gov/types/liver/patient/adult-liver-treatment-pdq#section/all. Adalwyd 29 September 2016. ... "Adult Primary Liver Cancer Treatment (PDQ®)-Patient Version". 6 July 2016. Archifwyd o'r gwreiddiol ar 2 October 2016. https:// ...
Neoplasms occurring in epithelial tissue such as the liver, gastrointestinal tract, and the pancreas have been linked to ... The regenerative and proliferative changes that occur in the liver during this time could increase the frequency of genetic ... Experimental cancer studies have shown that carbon tetrachloride may cause benign and malignant liver tumors to rainbow trout. ... Fish exposed to PAHs develop a range of liver lesions, some of which are characteristic of hepatocarcinogenicity. Nongenotoxic ...
Initial research on malignant neoplasms found mAb therapy of limited and generally short-lived success with blood malignancies ...
... liver cell MeSH C06.301.623.160 - carcinoma, hepatocellular MeSH C06.301.623.460 - liver neoplasms, experimental MeSH C06.301. ... liver cell MeSH C06.552.697.160 - carcinoma, hepatocellular MeSH C06.552.697.580 - liver neoplasms, experimental MeSH C06.552. ... common bile duct neoplasms MeSH C06.130.320.120 - bile duct neoplasms MeSH C06.130.320.120.280 - common bile duct neoplasms ... bile duct neoplasms MeSH C06.301.120.250.250 - common bile duct neoplasms MeSH C06.301.120.401 - gallbladder neoplasms MeSH ...
... liver neoplasms, experimental MeSH E05.598.500.496.843 - mammary neoplasms, experimental MeSH E05.598.500.496.937 - melanoma, ... liver cirrhosis, experimental MeSH E05.598.500.496 - neoplasms, experimental MeSH E05.598.500.496.500 - leukemia, experimental ...
... isolated Lissencephaly Listeria infection Listeriosis Livedoid dermatitis Liver cirrhosis Liver neoplasms Lobar atrophy of ... pulmonary Lymphangiomyomatosis Lymphatic filariasis Lymphatic neoplasm Lymphedema distichiasis Lymphedema hereditary type 1 ... syndrome Lung agenesis heart defect thumb anomalies Lung cancer Lung herniation congenital defect of sternem Lung neoplasm ... type Larsen syndrome Laryngeal abductor paralysis mental retardation Laryngeal carcinoma Laryngeal cleft Laryngeal neoplasm ...
... a freshwater catfish Malignant neoplasms of liver and intrahepatic bile ducts ICD-10 code Centre Municipal Airport FAA LID This ...
Neoplasms - Renal cell carcinoma or liver tumors, von Hippel-Lindau disease, and endocrine abnormalities including ... Symptoms include headaches and vertigo, and signs on physical examination include an abnormally enlarged spleen and/or liver. ... This physiologic polycythemia is a normal adaptation to living at high altitudes (see altitude sickness). Many athletes train ...
ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms ... 腫瘤:內分泌腺腫瘤(C73-C75/D34-D35、193-194/226-227(英語:List of ICD-9 codes 140-239: neoplasms#Malignant neoplasm of other and unspecified ... 最後一種則是主要發生在女性的胰黏液性囊狀腫瘤(英語:pancreatic mucinous cystic neoplasm)(MCNs),它可能維持良性或發展為惡性[61]。如果腫瘤
Mucinous cystic neoplasms of the liver are a type of liver cancer in which tissue similar to the stroma of ovary occurs. ... "Cystic tumor of the liver without ovarian-like stroma or bile duct communication: two case reports and a review of the ...
Although most associated neoplasms are gastrointestinal adenocarcinomas (stomach, liver, colorectal and pancreas), malignancies ... It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance ...
... , also known as intraductal papillary biliary neoplasm, is a rare type of liver ...
It is shown that mice given 20 µg/kg body weight 4 times a week during a period of 28 weeks developed neoplasms of the liver. ... After acute exposure, severe liver damage is noticeable by a disruption of liver cell structure. The liver weight will increase ... Liver damage could be noticed in 20 minutes. Within a few hours, liver cells died. Acute microcystin-LR intoxication may result ... The most common effect is liver damage, Two of the most commonly seen symptoms are gastroenteritis and cholestatic liver ...
... and anus 155 Malignant neoplasm of liver and intrahepatic bile ducts 156 Malignant neoplasm of gallbladder and extrahepatic ... 140 Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant ... benign neoplasm of uterus 220 Benign neoplasm of ovary 221 Benign neoplasm of other female genital organs 222 Benign neoplasm ... neoplasm of oropharynx 147 Malignant neoplasm of nasopharynx 148 Malignant neoplasm of hypopharynx 149 Malignant neoplasm of ...
Liver. *malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous ... This article about a neoplasm is a stub. You can help Wikipedia by expanding it.. *v ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Digestive_system_neoplasm&oldid=898746878" ...
Factor X (F10) is frequently expressed in normal liver and in liver cancers. SeV constructs were created with a modified ... It is also overexpressed in some cell lines originating from various malignant neoplasms. Thus, it is highly expressed in ... Plasminogen (PLG), from which originates the mini-plasmin that can cleave the F-protein, is highly expressed in liver cancers. ... and serve as SeV cell entry receptors are highly expressed in liver cancers. Cellular expression of glycoproteins can be ...
... enlarged liver (~16% of cases) and/or spleen (26% of cases), also due to malignant pDC infiltrations; increased levels of ... The neoplasm occurs in individuals of all ages but predominates in the elderly; in children, it afflicts males and females ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of ... Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy with features of cutaneous lymphoma (e.g. malignant ...
... malignant neoplasms take more than a further 7 million lives each year, approximately 3.5 million people die every year in ... Comparison - for our self-assessments about the quality of our lives, more important than how our lives go is how they go in ... If our lives are quite as bad as I shall still suggest they are, and if people were prone to see this true quality of their ... We want to live, and yet because of how we have evolved, we are the only species whose members are conscious that they are ...
It is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show significant sinusoidal infiltration in the liver ... The spleen and liver are always involved, and bone marrow involvement is common. Nodal involvement is exceedingly rare. The ...
Therefore, some studies have shown that the condition is harder to cure if the cancer has spread to the liver or brain or β-hCG ...
MRTs are a rare and highly malignant childhood neoplasm. Rhabdoid tumours outside the kidney were later reported in many ... tissues including the liver, soft tissue, and the central nervous system. Several cases of primary intracranial MRT have been ...
The compound closely resembles guanine and appears to be competitive with it in the metabolism of living organisms. It has been ... shown to cause retardation of some malignant neoplasms when administered to tumors in animals. 8-Azaguanine was the first ...
... produces short-lived cells that remain in the extramedullary regions of lymph nodes; a secondary response produces longer-lived ... Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of ... Recently they have been shown to reside for much longer periods in the bone marrow as long-lived plasma cells (LLPC). They ... and results in short-lived cells that secrete IgM antibodies.[6] The T cell-dependent processes are subdivided into primary and ...
... neoplasms including sarcomas such as hemangiopericytoma and malignant peripheral nerve sheath tumor in ... Aterman, K. (1981). Connective tissue: An eclectic historical review with particular reference to the liver. Histochem. J. 13: ...
Living brain tissue has a pink tint in color on the outside (gray matter), and nearly complete white on the inside (white ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ...
Of those who are blind 90% live in the developing world.[57] Worldwide for each blind person, an average of 3.4 people have low ... Malignant neoplasms of the brain and nervous system (1.5%). *Retinal detachment (1.4%) ... Linux distributions (as live CDs) for the blind include Vinux and Adriane Knoppix, the latter developed in part by Adriane ... About 90% of people who are visually impaired live in the developing world.[3] Age-related macular degeneration, glaucoma, and ...
In the 1950s, people who lived in the vicinity of the NTS were encouraged to sit outside and watch the mushroom clouds that ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ... While "downwinders" refers to those who live and work closest to the explosion site and are thus most acutely affected, there ... The estimate of those exposed to radioactive contamination due to living downwind of Hanford or ingesting food or water that ...
Salivary gland neoplasm. *Sarcoma. *Skin cancer. *Small intestine cancer. *Small-cell carcinoma ...
... live vector vaccine - liver function test (LFT) - long terminal repeat sequence (LTR) - long-term nonprogressors - LTR - lumbar ... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ...
Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ...
Legend: → tumor ←, ✱ central pleural effusion, 1 & 3 lungs, 2 spine, 4 ribs, 5 aorta, 6 spleen, 7 & 8 kidneys, 9 liver. ... Malignant tumor, malignant neoplasm. A coronal CT scan showing a malignant mesothelioma. ... "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015 ...
Neoplasms 60% increase in death rate 60% increased death rate from neoplasms. In 1999-2003, neoplasms accounted for 17% of all ... 69.2 years for those living in the Northern Territory to a high of 75.0 years for those living in New South Wales.[212][213][ ... "Living with the Past". FOCUS Asia-Pacific. Vol. 9. September 1997. Retrieved 25 September 2010.. ... Maynard, John; Haskins, Victoria (2016). Living with the Locals: Early Europeans' Experience of Indigenous Life. National ...
Any living organism that harbors another living organism (known as a "guest" or symbiont), whether the guest is parasitic, ... Any non-living chemical or physical part of the environment that affects living organisms and the functioning of ecosystems, ... A community of living organisms in conjunction with the non-living components of their physical environment, interacting as a ... Given that in biology many phyla, families and genera have some species that live in the sea and others that live on land, ...
When treating liver malignancies and metastases, it is possible for collateral radiation to cause gastric, stomach or duodenal ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... injection of yttrium-90 radioactive glass or resin microspheres into the hepatic artery to radioembolize liver tumors or liver ...
"ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms ... "Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Farrell JJ, Fernández-del Castillo C (juni 2013). "Pancreatic cystic neoplasms: management and unanswered questions". ... "ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: Well ...
... to decide who would live and who would die. As part of this effort, Lilly provided a group of physicians and bioethicists with ... Known or suspected intracranial neoplasm or mass lesion. *Known hypersensitivity to drotrecogin or any component ...
"Nuclear Chemistry: Half-Lives and Radioactive Dating - For Dummies". Dummies.com. 6 January 2010. Retrieved 17 June 2012.. ... "Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative ... However, such supplements were not consistently distributed to the population living nearest to the Chernobyl nuclear power ... The longer half-lived iodine-125 is also occasionally used when a longer half-life radioiodine is needed for diagnosis, and in ...
"Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... Treatment may also be inappropriate if a person has other serious health problems or is not expected to live long enough for ... it is likely that more elderly patients will be living long enough to suffer the consequences of their prostate cancer. ... Society of Clinical Oncology and the American College of Physicians discourages screening for those who are expected to live ...
1945). "Synthesis of a Compound Identical with the L. Casei Factor Isolated from Liver". Science. 102 (2644): 227-228. Bibcode: ... Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... Their biological availability to the body depends upon dihydrofolate reductase action in the liver. This action is unusually ... especially liver and kidneys, eggs, and some seafood.[8][71][72][73] Folate naturally found in food is susceptible to high heat ...
They are known to grow in the liver, but this finding is usually a manifestation of metastatic disease from a primary carcinoid ... cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm. *Mucinous cystic neoplasm ... If the tumor has metastasized (most commonly, to the liver) and is considered incurable, there are some promising treatment ... for arresting the growth of the tumors and prolonging survival in patients with liver metastases, though these are currently ...
ISBN 0-7020-2606-9. Huete-Garin, A.; S.S. Sagel (2005). "Chapter 6: "Mediastinum", Thymic Neoplasm". In J.K.T. Lee; S.S. Sagel ... These T cells are long-lived and can proliferate by homeostatic proliferation throughout the lifetime of the patient. However, ...
Over 50% of children with leukemia had one or more of five features: a liver one can feel (64%), a spleen one can feel (61%), ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... Medical imaging (such as ultrasound or CT scanning) can find invasion of other organs commonly the lung, liver, spleen, lymph ... Laboratory tests that might show abnormalities include blood count, kidney function, electrolyte, and liver enzyme tests.[17] ...
"Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri" ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ...
Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ...
... particularly the liver and spleen. This causes an enlargement of these organs. In the liver, the abnormal size is called ... In 2016, the WHO revised their classification of myeloproliferative neoplasms to define Prefibrotic primary myelofibrosis as a ... Sometimes unusual activity of the red blood cells, white blood cells, or platelets is seen.The liver is often moderately ... A physical exam of the abdomen may reveal enlargement of the spleen, the liver, or both.[3] ...
The liver damage can consist of damage to liver cells, hepatic sinusoidal syndrome (obstruction of the veins in the liver), ... Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... Hepatotoxicity (liver damage) can be caused by many cytotoxic drugs. The susceptibility of an individual to liver damage can be ... cholestasis (where bile does not flow from the liver to the intestine) and liver fibrosis.[104][105] ...
"Neoplasms and cancer" has been chosen to reflect the fact that not all tumours are benign. The word "cancer" has been included ... bile and liver. *functional gastrointestinal disorders. *laxatives. *peptic ulcer and reflux. *nausea and vomiting ...
McGregor NR (November 2007). "Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk". ... and there are concerns that taking alcohol and aspirin together may increase the risk of stomach bleeding and liver damage.[33] ... liver damage) due to cholestasis and acute pancreatitis.[34][35] ... subjects to an increased risk of acetaldehyde-related neoplasm ...
In the liver, the enlargement of hepatocytes due to fatty change may compress adjacent bile canaliculi, leading to cholestasis ... Carcinogenesis and Neoplasm) and reference[24]). Furthermore, the ability of HRR to accurately and efficiently repair double- ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... A high-salt diet is linked to gastric cancer.[45] Aflatoxin B1, a frequent food contaminant, causes liver cancer.[45] Betel nut ... Legend: → tumor ←, ✱ central pleural effusion, 1 & 3 lungs, 2 spine, 4 ribs, 5 aorta, 6 spleen, 7 & 8 kidneys, 9 liver. ... For example, cancers of the liver parenchyma arising from malignant epithelial cells is called hepatocarcinoma, while a ...
Living brain tissue has a pink tint in color on the outside (gray matter), and nearly complete white on the inside (white ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ...
Bernatsky S, Clarke AE, Suissa S (February 2008). "Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis ... in the liver to active metabolites.[32][33] The main active metabolite is 4-hydroxycyclophosphamide, which exists in ... Myeloproliferative neoplasms, including acute leukemia, non-Hodgkin lymphoma and multiple myeloma, occurred in 5 of 119 ... liver and intestinal epithelium. ALDHs protect these actively proliferating tissues against toxic effects of phosphoramide ...
Liver Neoplasms Cancer trial. Review trial description, criteria and location information here. ... Pfizer is currently recruiting for the NCT00106054 Colorectal Neoplasms, ... Neoadjuvant Colorectal Cancer With Unresectable Liver Metastases. Back to Search Print Save as PDF Bookmark Trial ... Neoadjuvant Colorectal Cancer With Unresectable Liver Metastases Official Title ICMJE An Open-Label, Multi-Center Phase II ...
Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver ... Gene context of Liver Neoplasms. *The Cul4A gene is amplified in human breast and liver cancers, and loss-of-function of Cul4 ... Disease relevance of Liver Neoplasms. *Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency [1]. ... High impact information on Liver Neoplasms. *We investigated whether IKKbeta is involved in chemically induced liver cancer, a ...
What is the little thing you can do to increase reproducibility, replicability and trust in science? How can reporting quality interfere with reproducibility issues and overall trust in science results? With that question in mind, we participated in the Reproducibility, Replicability and Trust in Science conference organised by the Wellcome Genome Campus from 9 to 11.... ...
Learn more about Liver Neoplasms, Experimental from related diseases, pathways, genes and PTMs with the Novus Bioinformatics ... Liver Neoplasms, Experimental: Disease Bioinformatics. Research of Liver Neoplasms, Experimental has been linked to Liver ... Liver Neoplasms, Experimental has been studied in relation to diseases such as: *Liver Carcinoma ... Carcinoma, Neoplasms, Carcinoma, Malignant Neoplasms, Hepatocarcinogenesis. The study of Liver Neoplasms, Experimental has been ...
OVERVIEW: What every practitioner needs to know Are you sure your patient has a liver neoplasm? What are the typical findings ... OVERVIEW: What every practitioner needs to know Are you sure your patient has a liver neoplasm? What are the typical findings ... What are the possible outcomes of liver neoplasms?. Hepatoblastoma that can be resected is typically very curable. Certain ... Surgical resection is typically required as part of curative therapy for primary liver neoplasms. A variety of benign tumors ...
Mucinous cystic neoplasms of the liver and extrahepatic biliary tree have recently been re-defined by WHO as epithelial cystic ... Cystic neoplasms of the liver are rare while simple liver cysts are common, seen in 2.5-18% of population [54]. Radiological ... Mucinous cystic neoplasm with high-grade intraepithelial neoplasia. 8470/2. Mucinous cystic neoplasms of the liver with an ... Mucinous cystic neoplasms of the liver are cystic, usually large and solitary. To distinguish these tumours from simple liver ...
Experimental Liver Neoplasms Summary Description: Experimentally induced tumors of the LIVER.. Also Known As: Liver Neoplasms, ... Key Therapies for Experimental Liver Neoplasms. Efficacy Chart ,, * Photochemotherapy (Photodynamic Therapy) : 1 study in 3 ... Key Drugs and Agents for Experimental Liver Neoplasms. Efficacy Chart ,, Drugs and Important Biological Agents (IBA) related to ... Experimental; Experimental Hepatoma; Experimental Hepatomas; Hepatomas, Experimental; Neoplasms, Experimental Liver Show All ,, ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications.. Chen ... The overall hazard rate of malignant neoplasm of the liver was 32.76 and 17.41 per 10,000 patient-years, respectively, for ... Compared with control subjects, diabetic patients had a two-fold increased risk of malignant neoplasm of the liver, but this ... This population-based study confirms the association of diabetes with liver neoplasm and suggests that diabetic patients with ...
mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms. Fikret Sahin, Rajesh Kannangai, Onikepe Adegbola, Jianzhou Wang, ... mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms. Fikret Sahin, Rajesh Kannangai, Onikepe Adegbola, Jianzhou Wang, ... mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms. Fikret Sahin, Rajesh Kannangai, Onikepe Adegbola, Jianzhou Wang, ... mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms Message Subject (Your Name) has forwarded a page to you from ...
Neoplasms. Liver Diseases. Fatty Liver. Colorectal Neoplasms. Non-alcoholic Fatty Liver Disease. Digestive System Diseases. ... Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Gastrointestinal Diseases. ... Study of the Association of Nonalcoholic Fatty Liver Disease With Colorectal Malignant Neoplasm (NWC). The safety and ... Colorectal Neoplasms Nonalcoholic Fatty Liver Disease Other: Ultrasound examination and Colonoscopy examination ...
How to Earn Credit Participants must attend and participate in the entire live educational activity and complete the posttest ... Power-Pak C.E. is pleased to present a complimentary live CE webinar. ... play to drive appropriate access to and use of BTK inhibitors to optimize outcomes for patients with mature B-cell neoplasms. ...
Adherence to the American Association for the Study of Liver Diseases criteria for evaluation and treatment of chronic HBV ... Coffee consumption associated with reduced liver cancer risk, no link to biliary tract cancer ... Consuming 3 or more alcoholic drinks per day may increase liver cancer risk ...
HEPATIC NEOPLASM , Adenocarcinoma , Cabozantinib toLERANCE Study in HepatoCellular Carcinoma (CLERANCE) ... percutaneous ablation or liver transplantation. When the tumor mass is larger (, 3 nodules) but remains confined to the liver, ...
Malignant neoplasm of gallbladder , Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery ... Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Brief description of study. *It has been shown that ... Patients undergoing liver resection surgery are randomized into 2 groups. *One of the groups receives sevoflurane and the other ... Inclusion criteria: Forty adult patients (20 patients in each group) who are planned to undergo liver resection surgery are ...
Segment-oriented approach to liver resection in the treatment of malignant hepatic neoplasms. The Journal of the American ... Segment-oriented approach to liver resection in the treatment of malignant hepatic neoplasms. J Am Osteopath Assoc 1999;99(2): ... Segment-oriented approach to liver resection in the treatment of malignant hepatic neoplasms ... Segment-oriented approach to liver resection in the treatment of malignant hepatic neoplasms ...
Ruben Mesa shares his thoughts on how treatment and research can be further improved for patients living with MPNs. ... Man Living With Myeloma Runs 1,200 Miles Across North Carolina. Patient advocates accomplish amazing feats that transcend the ... LIVE Webinar: Clinical Trial MythBusters. Is It Difficult to Participate in a Clinical Trial? ... Inglês] Living Stronger and Longer with MPNs. Published on February 3, 2014. ...
C22.8 Malignant neoplasm of liver, primary, unspecified as to type. * C22.9 Malignant neoplasm of liver, not specified as ... C15-C26 Malignant neoplasms of digestive organs › Malignant neoplasm of liver and intrahepatic bile ducts C22- >. Use ... C22 Malignant neoplasm of liver and intrahepatic bile ducts* C22.0 Liver cell carcinoma ... Secondary malignant neoplasm of liver and intrahepatic bile duct. 2016 2017 2018 2019 2020 Billable/Specific Code ...
Michael Grunwald and nurse, Erin Blackwell, discuss how doctors are helping MPN patients live well and maintain their quality ... how do I help this patient live long? And then, how do I help this patient live well? I think the "living well" part is the ... Esther and I were living in Spain for a little while. My doctor there was an MPN doctor, Dr. Cervantes, and I knew he wanted to ... Man Living With Myeloma Runs 1,200 Miles Across North Carolina. Patient advocates accomplish amazing feats that transcend the ...
The patient was admitted to our Department in 2017 with a liver metastasis of a neuroendocrine tumour. On admission she had no ... Liver metastasis of a neuroendocrine neoplasm of unknown primary origin in a female patient with a history of breast cancer. ... "Liver metastasis of a neuroendocrine neoplasm of unknown primary origin in a female patient with a history of breast cancer". ... "Liver metastasis of a neuroendocrine neoplasm of unknown primary origin in a female patient with a history of breast cancer." ...
... Barnardt, Pieter ; Relling, Martha (2015-07-03) ... Gestational trophoblastic neoplasm and women living with HIV and/or AIDS. Southern African Journal of HIV Medicine, 16(1), Art ... Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12-0.7/1000 ...
Benign liver neoplasms encompass a variety of liver lesions, each with distinct pathologic, radiographic, and molecular ... "Benign Liver Neoplasms." Maingots Abdominal Operations, 13e Zinner MJ, Ashley SW, Hines O. Zinner M.J., Ashley S.W., Hines O ... Soares K.C., Pawlik T.M. Soares, Kevin C., and Timothy M. Pawlik.Benign Liver Neoplasms. In: Zinner MJ, Ashley SW, Hines O. ... As a result, a thorough understanding of benign liver neoplasms is necessary to more accurately and appropriately screen ...
OVERVIEW: What every practitioner needs to know Are you sure your patient has a liver neoplasm? What are the typical findings ... OVERVIEW: What every practitioner needs to know Are you sure your patient has a liver neoplasm? What are the typical findings ... What are the possible outcomes of liver neoplasms?. Hepatoblastoma that can be resected is typically very curable. Certain ... What are the possible outcomes of liver neoplasms?*What is the evidence?*Ongoing controversies regarding etiology, diagnosis, ...
Malignant neoplasm of liver and intrahepatic bile ducts. 2016 2017 2018 Non-Billable/Non-Specific Code Type 1 Excludes* ... Personal history of malignant neoplasm of liver. 2016 2017 2018 Billable/Specific Code POA Exempt *Z85.05 is a billable/ ... Z85.1 Personal history of malignant neoplasm of trachea, bronchus and lung Z85.11 Personal history of malignant neoplasm of ... Z85.118 Personal history of other malignant neoplasm of bronchus and lung Z85.12 Personal history of malignant neoplasm of ...
Build: Fri Jul 27 09:23:34 EDT 2018 (commit: a5c8d99). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
"Liver Neoplasms" by people in this website by year, and whether "Liver Neoplasms" was a major or minor topic of these ... "Liver Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Liver Neoplasms" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Liver Neoplasms". ...
... primary liver tumors remain the second leading cause of death from cancer in males and the sixth leading cause of death from ... primary liver tumors will be diagnosed in approximately 42,220 new patients in the United States, and approximately 30,200 ... The 2 most common hepatic neoplasms are hepatocellular carcinoma (HCC), which accounts for more than 75% of primary liver ... Jan 6, 2019 , Posted by drzezo in ABDOMINAL MEDICINE , Comments Off on Malignant Liver Neoplasms ...
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... by Oscar 3.3 ... Eclipse download Neoplasms of the Liver of June 30, 1973. After accessing on Gran Canaria as a misconfigured identifying grade ... To be the download Neoplasms of the Liver storage definition the time in the AAVE-Esperanto we safely occurred you. The Ellen ... The download Neoplasms of the and light of misconfigured proud panels during an kö have the reports of detail and network, ...
Selected genes are highlighted in orange, bookmarked genes are green. - Chemical increases gene, - Chemical decreases gene, - Chemical increases and decreases gene simultaneosly, No arrows - gene doesnt interact with the chemical. - Gene should be increased/decreased most of the time and the chemical does it. - Gene should be increased/decreased most of the time but the chemical does the opposite. ...
  • Underlying liver dysfunction and associated jaundice or ascites are extremely rare as primary presenting features and are usually present only when hepatocellular carcinoma develops in a patient with a history of underlying liver disease. (clinicaladvisor.com)
  • To study protein expression in a large number of hepatocellular tumors, tissue arrays were constructed from formalin-fixed, paraffin-embedded tissues on all hepatocellular neoplasms in the Johns Hopkins Surgical pathology files with available tissues from 1985 to 2001, including 73 typical hepatocellular carcinomas, 15 hepatic adenomas, and 13 fibrolamellar carcinomas. (aacrjournals.org)
  • Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide and cause a wide spectrum of liver damage, such as steatohepatitis, cirrhosis, even end-stage liver disease and hepatocellular carcinoma. (clinicaltrials.gov)
  • histology of hepatic tumors revealed a combined hepatocellular and cholangiocellular carcinoma in the non-cirrhotic liver with severe acute centrilobular congestion. (lookfordiagnosis.com)
  • 0.001) and were transplanted more often in patients with preserved liver function and hepatocellular carcinoma and liver cirrhosis (n = 121, 74.7% of indications). (nih.gov)
  • Onofre AS, Pomjanski N, Buckstegge B, Böcking A. Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies. (springer.com)
  • Herein, we describe a series of patients without known liver disease or pathology receiving ruxolitinib who experienced hepatocellular damage and had a liver biopsy performed that assisted in their subsequent management. (online-prednisone-purchase.com)
  • 2. We therefore developed a quantitative immunohistochemical assay and monitored epoxide hydrolase expression in hepatocellular carcinomas (HCC, n = 20), cholangio-cellular carcinomas (CCC, n = 2) and liver metastases (n = 57) of tumours of various origins, and compared the expression intensities and patterns to normal liver tissue. (geoscience.net)
  • 4. When using a quantitative immunohistochemical approach statistically significant differences in microsomal epoxide hydrolase expression were observed between normal tissue, hepatocellular carcinoma and liver metastases (mean optical density 2.35, 1.63 and 0.21 respectively, p = 2.9, 6.3 and 18.9). (geoscience.net)
  • INTRODUCTION: In most cases, hepatocellular carcinoma (HCC) affects patients with liver cirrhosis. (usp.br)
  • One cat had hepatocellular carcinoma (HCC), one had cholangiocarcinoma (CC), and one had a malignant epithelial liver tumor (MELT) of unspecified histotype. (americanelements.com)
  • The incidence of hepatocellular carcinoma and intra-hepatic cholangiocarcinoma is more noted on top of chronic liver diseases. (omicsonline.org)
  • Furthermore, DWI seems to improve the perceptibility of focal hepatic lesions, especially of hepatocellular carcinomas (HCCs) in patients with liver cirrhosis as the heterogenecity and increased signal intensity of the cirrhotic liver parenchyma as a result of nodular regeneration, fibrosis, and scarring appears became less pronounced on DWI compared to T2-weighted images [ 11 ]. (omicsonline.org)
  • These drugs are not approved for the treatment of colorectal cancer liver metastases (CRCLM) who can have surgery. (clinicaltrials.gov)
  • If the liver metastases after the chemotherapy and surgery decreases or stops growing, then chemotherapy will be given after surgery. (clinicaltrials.gov)
  • Even after complete resection of isolated liver metastases, recurrence develops in the majority of patients. (springer.com)
  • Therefore, development of strategies to prevent recurrent liver metastases is of major clinical importance. (springer.com)
  • The present prospectively randomised phase III trial investigates the efficiency of active specific immunotherapy (ASI) after liver resection for hepatic metastases of colorectal cancer. (springer.com)
  • Patients with histologically confirmed liver metastases from colorectal cancer were randomised to the vaccination or control group. (springer.com)
  • After complete resection of liver metastases, patients randomised to the vaccination group received six doses of Newcastle disease virus (NDV) infected autologous tumour cell vaccine (ATV-NDV). (springer.com)
  • Ballantyne GH, Quin J (1993) Surgical treatment of liver metastases in patients with colorectal cancer. (springer.com)
  • Bengmark S, Hafstrom L (1969) The natural history of primary and secondary malignant tumors of the liver, I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy. (springer.com)
  • de Brauw LM, van de Velde CJ, Bouwhuis-Hoogerwerf ML, Zwaveling A (1987) Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases. (springer.com)
  • Figueras J, Valls C, Rafecas A, Fabregat J, Ramos E, Jaurrieta E (2001) Resection rate and effect of postoperative chemotherapy on survival after surgery for colorectal liver metastases. (springer.com)
  • We report results of using isolated hepatic perfusion (IHP) in patients with advanced progressive liver metastases (LM) from pancreatic and gastrointestinal neuroendocrine neoplasms (NENs). (elsevier.com)
  • All three cases showed metachronous multiple liver metastases after 9-13 years of follow-up for EMR, despite achieving complete resection and without muscular invasion. (springeropen.com)
  • Abdominal computed tomography (CT) revealed multiple liver masses in the bilateral lobe (Fig. 2 a) diagnosed as multiple liver metastases by biopsy concordant with the initial tumor. (springeropen.com)
  • Colonoscopy and colon biopsies showed adenocarcinoma of the colon and laparotomy confirmed metastases to the liver. (biomedsearch.com)
  • The most common malignant lesions in non-cirrhotic livers are metastases. (omicsonline.org)
  • The procedure, mostly used in combination with systemic chemotherapy, plays a role in the treatment of liver metastases in patients with colorectal cancer (CRC). (wikipedia.org)
  • Although surgical resection remains the standard of care for these liver metastases, majority of patients have lesions that are unresectable. (wikipedia.org)
  • Liver metastases get most of their blood supply primarily from the hepatic artery, whereas the normal liver cells get their blood supply from the portal circulation. (wikipedia.org)
  • Considering improvements in the surgical placement of the HAI pump and studies showing promising results when HAI therapy is used together with systemic oxaliplatin or irinotecan, there is once again an increased interest in the role of HAI as a treatment option in patients with cancer, who have unresectable CRC liver metastases. (wikipedia.org)
  • Patient with hepatic metastatic disease from neuroendocrine tumors, gastrointestinal stromal tumors other sarcomas, ocular melanoma, and a variety of "hypervascular" metastases (eg from breast cancer or renal cell cancer) may also be candidates for bland embolization, assuming the liver is the only site of disease, or when the procedure is being performed for palliation of symptoms. (wikipedia.org)
  • 4 The degree of liver change that results from hepatitis before development of HCC differs between hepatitis B and C. Among patients with hepatitis B, 20% of HCC cases develop before cirrhosis develops, whereas among patients with hepatitis C, HCC almost always arises in the background of significant cirrhosis and fibrosis. (abdominalkey.com)
  • Other risk factors for HCC include environmental exposures, chronic disease processes, and genetic conditions that predispose patients to development of cirrhosis and/or chronic liver inflammation. (abdominalkey.com)
  • Metabolism of alcohol occurs through oxidative processes, resulting in lipogenesis and fatty liver development that can progress to cirrhosis. (abdominalkey.com)
  • About 50% of alcoholics have no detectable liver disease, 30% have alcoholic hepatitis, and 20% develop cirrhosis. (mhmedical.com)
  • Alcoholic liver disease may be manifested as fatty liver, alcoholic hepatitis, or alcoholic cirrhosis ( Figure 43-1 ). (mhmedical.com)
  • Transthoracic echocardiography revealed a dilated inferior vena cava (IVC) and hepatic vein, suggesting cardiogenic liver cirrhosis (LC) caused by a prosthetic tricuspid valve obstruction. (clinicalultrasound.org)
  • 심인성 간경화(cardiogenic liver cirrhosis)는 간 조직 구조의 변형과 재생성 결절 형성을 특징으로 하는 말기 간 섬유화가, 우측 심장부전으로 인해 발생되었을 때를 일컫는다. (clinicalultrasound.org)
  • Chronic Diarrhea as First Manifestation of Liver Cirrhosis a. (lww.com)
  • Chronic diarrhea has been described as one manifestation of liver cirrhosis and HCC. (lww.com)
  • Cirrhosis, viral hepatitis, and toxic drug effects can all trigger apoptosis in the liver as a means of removing the unwanted cells, and the Fas "death receptor" pathway comprises a major physiological mechanism by which this occurs. (biomedsearch.com)
  • About 90% of HCCs develop in cirrhotic livers, mainly associated with hepatitis B or C. Liver transplantation (LTx) is now the best treatment for patients with cirrhosis and HCC 1 . (scielo.br)
  • Patients with non-cancer liver conditions such as cirrhosis, adenoma, cholangioma, or nodular hyperplasia. (knowcancer.com)
  • In human liver, the appearance of connective tissue extending out from portal areas is pathological, the defining characteristic of cirrhosis. (siumed.edu)
  • The majority of patients with HCC have underlying liver disease with resultant cirrhosis. (wikipedia.org)
  • Patients with underlying liver disease require a greater volume of liver remnant to maintain hepatic function, thus, tumors that might normally be resectable in patients with normal liver parenchyma may not be resectable in the presence of cirrhosis. (wikipedia.org)
  • Patients with Child-Pugh class C cirrhosis may be more likely to die of their underlying liver disease than of their HCC and are unlikely to tolerate arterial embolization well and therefore, embolization therapy is only indicated in patients with Child A or B cirrhosis. (wikipedia.org)
  • Although selective embolization of a solitary well circumscribed HCC in a patient with Child Class B cirrhosis might be well tolerated, embolization of a hemi-liver in a Child A patient with multifocal hepatoma involving more than 75% of the liver and with portal vein tumor thrombus may result in hepatic failure and severe death. (wikipedia.org)
  • Mucinous cystic neoplasms of the liver and extrahepatic biliary tree have recently been re-defined by WHO as epithelial cystic tumours with ovarian-type mesenchymal stroma. (intechopen.com)
  • Mucinous cystic neoplasms of the liver [ 1 ], formerly known as bile duct/biliary cystadenoma and biliary cystadenocarcinoma [ 2 ], represent an enigmatic entity, characterised by unknown origin and peculiar morphology including the presence of ovarian-type stroma. (intechopen.com)
  • To enhance the knowledge of medical society on the mucinous cystic neoplasms of the liver, here we aim to summarise contemporary data on these tumours, including the current definition and classification [ 1 ], the recent molecular genetic findings [ 3 , 4 ] as well as the practical issues of clinical presentation, diagnostic approach, treatment and prognosis. (intechopen.com)
  • Currently, mucinous cystic neoplasms of the liver are defined as epithelial cystic tumours associated with ovarian-type mesenchymal stroma. (intechopen.com)
  • Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression. (cdc.gov)
  • To compare the oncogenic mutation status among mucinous cystic neoplasms (MCNs) of different histological grades and between liver and pancreatic MCNs. (cdc.gov)
  • Mucinous cystic neoplasms (MCNs) represent one of the major cystic neoplasms of the pancreas. (biomedcentral.com)
  • This trial is studying the effects (good and bad) of a combination of drugs, Irinotecan in combination with infusional 5-FU, leucovorin (FOLFIFI) plus Bevacizumab, for cancer of the colon or rectum that has spread to the liver only and is currently not able to be removed by surgery. (pfizer.com)
  • All of the drugs that will be received in this research study have been approved in the United States for colorectal cancer, that has spread to other areas of the body, including the liver. (pfizer.com)
  • Another reason for doing this study is to see if the chemotherapy drugs FOLFIFI plus Bevacizumab can sufficiently decrease the size of the cancer in the liver so that any tumor remaining can be completely removed with surgery and, if it can be removed whether doing so will prolong the time it takes the cancer to return and/or prolong the life of these patients. (pfizer.com)
  • Hepatoblastoma is the most common malignant tumor of the liver, typically occurs in the first few years of life, and accounts for two thirds of all liver cancer in children. (clinicaladvisor.com)
  • The aim of this sudy is to investigate the prevalence of colorectal cancer (CRC) in patients with nonalcoholic fatty liver disease (NAFLD) and evaluate whether NAFLD is a risk factor for CRC. (clinicaltrials.gov)
  • Study of the Prevalence of Colorectal Cancer in Patients With Nonalcoholic Fatty Liver Disease. (clinicaltrials.gov)
  • Patients were performed colonoscopy examination for colorectal cancer and who had been foud colorectal cancer proven by biopsy.Then the colorectal cancer patients who had not been diagnosed with nonalcoholic fatty liver disease was based on blood tests and abdomen ultrasound examination. (clinicaltrials.gov)
  • From a recent MPN town meeting at Carolinas HealthCare System's Levine Cancer Institute, MPN specialist Dr. Michael Grunwald and nurse, Erin Blackwell, share insight on how doctors are helping patients live well and maintain their quality of life. (patientpower.info)
  • Absolutely, and so, whenever I had a new cancer patient, whether it's an MPN patient or a patient with another type of blood cancer, my thoughts are, how do I help this patient live long? (patientpower.info)
  • Struk-Panfill M, Błaut K, Pęksa R, Kmieć P, Sworczak K. Liver metastasis of a neuroendocrine neoplasm of unknown primary origin in a female patient with a history of breast cancer. (termedia.pl)
  • Tumors or cancer of the LIVER. (viictr.org)
  • Authors' reply to: Statin use and risk of liver cancer. (viictr.org)
  • 1 Worldwide, primary liver tumors remain the second leading cause of death from cancer in males and the sixth leading cause of death from cancer in females. (abdominalkey.com)
  • Due to the potential for malignant transformation to become a cystadenocarcinoma cancer, mucinous cystic neoplasm of the liver requires a surgical removal via liver resection . (iswantosucandyliversurgery.com)
  • to understand the experience of rural families living with advanced cancer , from Family Management Style Framework's perspective. (bvsalud.org)
  • Final Considerations living in rural context gives families specific ways of dealing with advanced cancer . (bvsalud.org)
  • Primary liver cancer starts in the liver. (medlineplus.gov)
  • Metastatic liver cancer starts somewhere else and spreads to your liver. (medlineplus.gov)
  • Doctors use tests that examine the liver and the blood to diagnose liver cancer. (medlineplus.gov)
  • What Is Liver Cancer? (medlineplus.gov)
  • What Happens After Treatment for Liver Cancer? (medlineplus.gov)
  • Do We Know What Causes Liver Cancer? (medlineplus.gov)
  • What Should You Ask Your Doctor about Liver Cancer? (medlineplus.gov)
  • What's New in Liver Cancer Research and Treatment? (medlineplus.gov)
  • This phase II trial studies how well temsirolimus and bevacizumab work in treating patients with advanced endometrial, ovarian, liver, carcinoid, or islet cell cancer. (clinicaltrials.gov)
  • Cancer is an important cause of death within the first 15 played an important role in assembling valuable data concerning some of the less common neoplasms. (indigo.ca)
  • O algoritmo do Barcelona Clinic Liver Cancer group (BCLC) considera função hepática, características tumorais e, estado geral do paciente para definir o tratamento. (usp.br)
  • Barcelona Clinic Liver Cancer group (BCLC) algorithm takes into consideration liver function, tumor variables and patients general status to guide therapy. (usp.br)
  • Hepatocarcinoma (HCC) is the most common malignant neoplasm of the liver and the sixth leading cause of cancer mortality worldwide, with an incidence of 750,000 new cases per year. (scielo.br)
  • This article presents a pilot study in housecats with unresectable liver cancer. (americanelements.com)
  • neoplasms of uncertain behavior" means a rare tumor that the pathologist cannot say with certainty either is or is not cancer . (healthtap.com)
  • Please would like to know what is meant by thyroid shows well defined follicular neoplasm composed of cells with granular cyloplasm, is it cancer? (healthtap.com)
  • A malignant neoplasm of the liver means cancer . (healthtap.com)
  • You need to know the nature of the neoplasm (a generic name saying it is likely cancer but you need to know what kind of cancer it might be). (healthtap.com)
  • Hepatoblastoma is the most common type of liver cancer to occur in children. (oncolink.org)
  • Liver cancer is a deadly cancer that is typically hard to diagnose and treat. (knowcancer.com)
  • The currently used blood marker for the clinical diagnosis of liver cancer is alpha-feto protein (AFP), which misses 40-60% of patients with liver cancer because it lacks sufficient specificity and sensitivity. (knowcancer.com)
  • The purpose of this study is to identify blood markers that have the ability to diagnose liver cancer with improved accuracy, so that it can be used alone or in conjunction with AFP. (knowcancer.com)
  • The aim of this study is to identify new blood markers of liver cancer that can be used to increase the rate of accurate diagnosis of this malignancy. (knowcancer.com)
  • Patients diagnosed with liver cancer based on biopsy or serum AFP level, associated with characteristic hypervascular liver tumors on triphasic spiral CT scan or MRI. (knowcancer.com)
  • Patients with hepatitis B or hepatitis C viral infections not associated with liver cancer. (knowcancer.com)
  • The results of the liver and brain cancer studies were consistent with an etiologic role for vinyl-chloride. (cdc.gov)
  • Although TACE is considered the gold standard and TAE has largely been abandoned as a primary hepatic intra-arterial therapy for primary liver cancer, there are a few studies that suggest sufficient anti-tumor effects of TAE. (wikipedia.org)
  • In 1999, Llovet et al, proposed the Barcelona Clinic Liver Cancer (BCLC) staging classification as a means of both classifying patients and linking their stage to a specific treatment. (wikipedia.org)
  • A rare autopsy case of primary liver carcinoma complicating a pre-existing, incomplete membranous obstruction of the inferior vena cava (MOVC) is reported. (lookfordiagnosis.com)
  • Squamous cell carcinoma of the liver: metastasis or primary neoplasm? (semanticscholar.org)
  • Fine needle aspiration of metastatic papillary thyroid carcinoma found in the liver. (springer.com)
  • Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors . (bvsalud.org)
  • Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications. (nih.gov)
  • We prospectively investigated 615,532 diabetic patients and 614,871 age-matched and sex-matched control subjects selected from National Health Insurance claims for malignant neoplasms of liver and biliary tract (International Statistical Classification of Diseases and Related Health Problems, 9th edition, codes 155 and 156, respectively) between 2000 and 2006. (nih.gov)
  • the corresponding figures for biliary tract neoplasm were much lower at 1.42 and 1.60 per 10,000 patient-years. (nih.gov)
  • Mucinous cystic neoplasm of the liver is an uncommon premalignant cystic lesion, which accounts for less than 5% of all intrahepatic biliary cysts and occurs primarily in middle aged woman with a peak incidence in the 50s. (iswantosucandyliversurgery.com)
  • Minimally invasive liver resection is recommended based on tumor location, size, proximity to major vascular and biliary structures. (iswantosucandyliversurgery.com)
  • In about 15% of patients, minimally invasive liver resection cannot be offered mainly due to tumor size, location, and proximity to or involvement of major vascular/biliary structures. (iswantosucandyliversurgery.com)
  • Over the past 56 years, thousands of physicians have depended on Diseases of the Liver and Biliary System . (wiley.com)
  • This brand-new edition, now named Sherlock's Diseases of the Liver and Biliary System , after the late Professor Dame Sheila Sherlock, continues to provide concise clinical guidance for all those treating patients with hepato-biliary disease. (wiley.com)
  • Biliary cystadenoma represents a rare benign cystic hepatic neoplasm that has premalignant potential. (medscape.com)
  • The patient was admitted to our Department in 2017 with a liver metastasis of a neuroendocrine tumour. (termedia.pl)
  • N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. (viictr.org)
  • Fernandez-Trigo V, Shamsa F, Sugarbaker PH (1995) Repeat liver resections from colorectal metastasis. (springer.com)
  • Here, we report three cases of metachronous liver metastasis after long-term follow-up of endoscopic mucosal resection (EMR) for rectal NEN. (springeropen.com)
  • Here, we report three cases of metachronous liver metastasis after long-term follow-up of endoscopic mucosal resection (EMR) and discuss the current problems underlying the treatment options for small rectal NEN with a review of the literature. (springeropen.com)
  • Since immunohistochemistry staining of the liver metastasis showed somatostatin-2 receptor (SSTR-2) positivity, monthly intramuscular octreotide 30 mg was administered. (springeropen.com)
  • She died of liver metastasis 1 year after the initial treatment. (springeropen.com)
  • There's a lot of support you - and those close to you - might need if you've been diagnosed with a myeloproliferative neoplasm (MPN). (bloodwise.org.uk)
  • Metastatic disease from other pediatric malignancies is more common than primary liver cancers and should always be considered. (clinicaladvisor.com)
  • Intraoperative Air Leak Test to Prevent Bile Leak After Right Posterior Sectionectomy with En Bloc Diaphragm Resection for Metastatic Teratoma. (viictr.org)
  • This chapter summarizes the key findings for the accurate morphological diagnosis of benign, malignant, and metastatic lesions of the liver. (springer.com)
  • A morphologically and immunohistochemically identical metastatic sarcomatous focus was identified in the liver without any glandular component. (biomedcentral.com)
  • Pictures of pancreatic cysts, cyst lined by benign mucinous epithelium, sarcomatous stroma in pancreas, and sarcomatoid metastatic foci in liver. (biomedcentral.com)
  • Focal areas of dense, acellular, hyalinized tissue are evident (H & E, 20×) ( D ) Sarcomatoid metastatic foci in liver. (biomedcentral.com)
  • What is malignant neoplasm of colon and what causes it? (healthtap.com)
  • This population-based study confirms the association of diabetes with liver neoplasm and suggests that diabetic patients with certain clinical risk factors should be educated for strict adherence of liver neoplasm screening. (nih.gov)
  • Goal Statement The goal of this educational activity is to inform and educate oncology, managed care and specialty pharmacists on differences in pharmacology, efficacy, and safety of BTK inhibitors and roles that pharmacists can play to drive appropriate access to and use of BTK inhibitors to optimize outcomes for patients with mature B-cell neoplasms. (powerpak.com)
  • It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI). (centerwatch.com)
  • Patients undergoing liver resection surgery are randomized into 2 groups. (centerwatch.com)
  • Inclusion criteria: Forty adult patients (20 patients in each group) who are planned to undergo liver resection surgery are included. (centerwatch.com)
  • Exclusion criteria: Patients who undergo less invasive liver resection surgery under thoracoscopy or laparoscopy are excluded. (centerwatch.com)
  • Dr. Ruben Mesa, director of the acute and chronic leukemias program in the division of hematology-oncology at Mayo Clinic in Arizona, shares his thoughts on how treatment and research can be further improved for patients living with MPNs and the continuous exploration of combination therapy. (patientpower.info)
  • Watch, as Dr. Mesa discusses some of the trials he's leading that continue to help patients live stronger and longer. (patientpower.info)
  • As a result, a thorough understanding of benign liver neoplasms is necessary to more accurately and appropriately screen patients for expectant management versus surgical intervention. (mhmedical.com)
  • In 2018, primary liver tumors will be diagnosed in approximately 42,220 new patients in the United States, and approximately 30,200 individuals will die from this disease. (abdominalkey.com)
  • In patients with primary hepatic malignancies, the malignancy itself and any underlying liver disease must be considered as 2 separate but interconnected pathologic processes. (abdominalkey.com)
  • We performed a retrospective review of hepatic damage occurring in patients with myeloproliferative neoplasms receiving ruxolitinib. (online-prednisone-purchase.com)
  • We conclude that hepatology referral and liver biopsy in patients receiving ruxolitinib therapy with biochemical evidence of liver injury reveals a variety of etiologies which have significant treatment impact. (online-prednisone-purchase.com)
  • to increase awareness amongst patients, physicians and caregivers of myeloproliferative neoplasms. (lls.org)
  • to compare the outcome of liver transplantation for hepatocarcinoma in submitted or not to locoregional treatment and downstaging regarding survival and risk of recurrence in transplant waiting list patients. (scielo.br)
  • retrospective study of patients with hepatocarcinoma undergoing liver transplantation in the metropolitan region of São Paulo, between January 2007 and December 2011, from a deceased donor. (scielo.br)
  • Patients with myeloproliferative neoplasms (MPNs), including myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET), report high symptom burden that may compromise activities of daily living and quality of life. (ashpublications.org)
  • Background: Patients with the myeloproliferative neoplasms (MPNs) myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are at increased risk for thrombotic and cardiovascular events and experience a variety of burdensome symptoms. (uthscsa.edu)
  • Studies with patients submitted to LLS for living donation were excluded. (usp.br)
  • AFP is produced by immature liver cells, and 90% of patients with hepatoblastoma will have elevated AFP levels. (oncolink.org)
  • Before the placement of the HAI pump, the patients undergo an arteriogram to outline the blood supply of the liver and to identify any anatomical anomalies. (wikipedia.org)
  • Patients undergoing HAI therapy therefore have regular liver function tests to monitor any damage to the liver. (wikipedia.org)
  • Patients with normal liver function and, presumably, normal hepatic parenchyma may undergo resection of 75% to 80% of their liver without developing postoperative hepatic failure. (wikipedia.org)
  • The Child-Pugh nominal liver staging system is the most accurate in predicting survival of patients with unresectable HCC treated with TACE and TAE. (wikipedia.org)
  • To provide a comprehensive, easy to navigate resource hub for the study of Myeloproliferative Neoplasms (MPNs) such as Polycythemia Vera, Essential Thrombocythemia and Myelofibrosis. (lls.org)
  • This analysis of the Living with MPNs survey was conducted to evaluate the impact of MPNs on employment, career potential, and work productivity. (uthscsa.edu)
  • Currently employed respondents reported meaningful impairments in work productivity and activities of daily living that were attributable to their MPNs, and the degree of impairments highlighted the severity of symptom burden. (uthscsa.edu)
  • Myeloproliferative Neoplasms (MPNs) are blood cancers that occur when the body makes too many white or red blood cells, or platelets. (cancersupportcommunity.org)
  • MPNs were called Myeloproliferative Diseases until 2008 when the World Health Organization reclassified them as cancers and renamed them Myeloproliferative Neoplasms. (cancersupportcommunity.org)
  • Marilyn discusses the role played by emotional support in helping her live well with MPNs. (cancersupportcommunity.org)
  • PV is one of three myeloproliferative neoplasms (MPNs). (cancersupportcommunity.org)
  • This genetic alteration was slightly more frequent in the pancreas than in the liver [4/17 (24%) versus 1/8 (13%), P = not significant]. (cdc.gov)
  • Fine-needle aspiration of the liver and pancreas: a cytology primer for radiologists. (springer.com)
  • We report a case of mucinous cystic neoplasm of pancreas with sarcomatous stroma metastasizing to the liver. (biomedcentral.com)
  • A variety of liver pathology was observed including extramedullary hematopoiesis, obliterative portal venopathy, and drug-induced liver injury. (online-prednisone-purchase.com)
  • Surgical resection is typically required as part of curative therapy for primary liver neoplasms. (clinicaladvisor.com)
  • In the early stages (low tumor mass), HCC can be treated for curative purposes by surgical resection, percutaneous ablation or liver transplantation. (centerwatch.com)
  • The aim of this study is to prove the hypothesis that desflurane is safer than sevoflurane in terms of the association with postoperative acute kidney injury (AKI) after liver resection surgery. (centerwatch.com)
  • An extended right hepatectomy with supra- to retrohepatic IVC resection was performed in an en bloc fashion using a centrifugal pump for hepatic vascular exclusion (HVE). (lookfordiagnosis.com)
  • Minimally invasive technique with laparoscopic liver resection or robotic liver resection is preferred, when expertise is available. (iswantosucandyliversurgery.com)
  • Only few centers in the United Stated that offer minimally invasive liver resection routinely. (iswantosucandyliversurgery.com)
  • In Tampa Bay Area, Dr. Iswanto Sucandy performs robotic liver resection routinely for this type of liver mass. (iswantosucandyliversurgery.com)
  • Treatment for hydatic cyst is with administration of anthelmintic drugs followed by surgical liver resection removing the hydatic cyst intact. (iswantosucandyliversurgery.com)
  • Dr. Iswanto Sucandy and his team work collaboratively with their multispecialty partners to undertake liver resection in a minimally invasive fashion because of its known clinical advantages and long-term positive oncologic outcomes. (iswantosucandyliversurgery.com)
  • Laparoscopic resection has become an accepted approach to liver tumour surgery. (termedia.pl)
  • To compare the outcomes of laparoscopic (LLR) and open liver resection (OLR) of posterolateral segments. (termedia.pl)
  • Foster JH (1978) Survival after liver resection for secondary tumors. (springer.com)
  • Liver transplantation has been shown to be a promising alternative for those children who have non-resectable tumors. (oncolink.org)
  • However, whether the neoplasm is benign or malignant can be determined by biopsy, especially if some of the following symptoms are present: jaundice, abdominal pain, nausea and vomiting, dark-colored urine, unexplained loss of appetite with weight loss, and feeling bloated or full following a small portion of food. (livestrong.com)
  • Fine needle aspiration (FNA) and needle core biopsy are the most commonly used procedures for the morphological evaluation of liver lesions because of their decreased rates of procedural complications compared with open and more invasive approaches. (springer.com)
  • Fine-needle aspiration biopsy of the liver: diagnostic problems. (springer.com)
  • In all cases reviewed, the liver biopsy had significant treatment implications. (online-prednisone-purchase.com)
  • Clinicians should be aware of the potential causes of liver damage in this population and initiate prompt referral and liver biopsy. (online-prednisone-purchase.com)
  • 1 CM pituitary neoplasm, stable but has been called tumor, hypophysitis, nothing, leading to $1ks of mris with no certainty as to diagnosis of pituitary or partial adrenal insuff, biopsy worth risks? (healthtap.com)
  • Colonoscopy is the most accurate technique for diagnosis, surveillance and exclusion of colorectal neoplasm for high-risk CRC groups. (clinicaltrials.gov)
  • Thick gelatinous fluid form the cyst is consistent with mucinous cystic neoplasm diagnosis. (iswantosucandyliversurgery.com)
  • To investigate the utility value of monoexponential model,biexponential model and diffusion kurtosis model diffusion weighted imaging in diagnosis of liver neoplasms. (ismrm.org)
  • Although there have been many advancements in imaging techniques for the diagnosis of benign and malignant liver lesions, obtaining tissue for morphologic and molecular characterization is critical for diagnosis and treatment. (springer.com)
  • Methods: This cross-sectional online survey included respondents aged 18-70 years living in the United States with a diagnosis of MF, PV, or ET. (uthscsa.edu)
  • Although myeloproliferative neoplasms can pose health risks, people with these conditions often live for many years after diagnosis. (cancersupportcommunity.org)
  • Chronic clonorchiasis may be complicated with gallbladder and intrahepatic duct stones, recurrent pyogenic cholangitis, cholecystitis, liver abscess, and cholangiocarcinoma (5). (thefreedictionary.com)
  • In recent years, metabolic syndrome (MetS) - Including glucose tolerance, dyslipidemia, obesity, hypertension and chronic in﫿ammation - and its individual components have been proven to be the risk for colorectal neoplasm. (clinicaltrials.gov)
  • Although it has been also well established that MetS and its individual components are risk factors for colorectal neoplasm, as above, there is paucity of research looking at the relation between NAFLD and CRC. (clinicaltrials.gov)
  • Adherence to the American Association for the Study of Liver Diseases criteria for evaluation and treatment of chronic HBV infection was found to be poor in all practice settings assessed. (clinicaladvisor.com)
  • Participants encouraged prospective cohort studies of persons with chronic liver diseases in which the use of various screening modalities and regimens could be assessed and suggested that cost-effectiveness studies of AFP screening could be useful in decision-making. (cdc.gov)
  • It is one of the three most common myeloproliferative neoplasms (MPN) - rare blood diseases that develop when the bone marrow makes too many blood cells. (cancersupportcommunity.org)
  • NAFLD was diagnosed by the following criterion: hepatomegaly, the echogenicity of liver parenchyma increased diffusely, and vascular blurring. (clinicaltrials.gov)
  • Neoplasms display abnormal architecture of hepatic parenchyma. (siumed.edu)
  • Liver tumors represent approximately 1% of all childhood cancers resulting in 100-150 new cases diagnosed in the United States in children each year. (clinicaladvisor.com)
  • Rectal neuroendocrine neoplasms (NENs) are rare, but their incidence has increased in recent years. (springeropen.com)
  • The incidence is increasing, and in developed countries chronic liver disease and accidents associated with alcoholism are among the 10 most common causes of death. (mhmedical.com)
  • Alcoholic liver disease is most common in middle-aged men, but there is an increasing incidence among women and in the young. (mhmedical.com)
  • The greater the amount and the longer the duration of alcohol consumption, the greater the risk of liver disease. (mhmedical.com)
  • Not all heavy drinkers develop liver disease. (mhmedical.com)
  • Prediction of liver disease in individual cases is uncertain. (mhmedical.com)
  • Alcoholic liver disease. (mhmedical.com)
  • Chronic alcoholic liver disease, precirrhotic. (mhmedical.com)
  • The majority of hepatic (liver) cysts are unremarkable and never produce symptoms, however in some cases, hepatic cysts may signal an underlying disease. (livestrong.com)
  • Hepatic cysts are known to occur as the result of a genetic etiology, that is, polycystic liver disease. (livestrong.com)
  • Additionally, polycystic liver disease may be associated with polycystic renal disease, where multiple cysts are present also in the kidneys (see Liver Cyst Image in Resources). (livestrong.com)
  • The symptoms of HCC are usually those of chronic liver disease and are generally nonspecific ( 8 ). (lww.com)
  • There was no family history of liver disease or inherited disorders including Wilson disease, hemochromatosis, or alpha-1 antitrypsin deficiency. (lww.com)
  • There is no cure for ET but people with the disease often live normal lives. (cancersupportcommunity.org)
  • When evaluating a patient for embolization, both the severity of the underlying liver disease and the extent of the tumor being treated should be considered. (wikipedia.org)
  • The lower incidence of KRAS mutations in liver MCNs may also explain why the risk of malignant transformation in liver MCNs is lower than that in pancreatic MCNs. (cdc.gov)
  • The statistical powers of mortality studies were calculated with respect to the liver, brain, and lung sites and plotted on power curves to relate positive and negative findings to power, and to show the variability in powers. (cdc.gov)
  • Benign liver neoplasms encompass a variety of liver lesions, each with distinct pathologic, radiographic, and molecular characteristics. (mhmedical.com)
  • Benign liver lesions occur in up to 20% of the population and far surpass the incidence of malignant liver lesions. (mhmedical.com)
  • Benign liver lesions are usually asymptomatic and are generally observed. (mhmedical.com)
  • Liver lesions with equivocal imaging characteristics can lead to diagnostic uncertainty resulting in important therapeutic ramifications. (mhmedical.com)
  • Treatment algorithm for solitary liver lesions. (mhmedical.com)
  • Contrast-enhanced ultrasound (CEUS) represents a significant breakthrough in sonography and it is being increasingly used for evaluation of focal liver lesions (FLLs). (unipa.it)
  • Diagnostic imaging is an integral part of the patient evaluation for cystic lesions in the liver. (medscape.com)
  • Most of the hepatic focal lesions arising in non-cirrhotic livers are benign. (omicsonline.org)
  • Comparing contrast-enhanced ultrasound, CT, and MRI in evaluating incidental focal liver lesions, most of the published series reported similar diagnostic performance with specificities ranging from 82-89% and no significant difference in the summary characteristic between modalities [ 4 , 5 ]. (omicsonline.org)
  • Over the last few years, several studies have investigated the role of DWI in the detection of focal liver lesions. (omicsonline.org)
  • High SNRs and high lesion-to- liver signal intensity ratios are seen at low b values alleviating the depiction of focal liver lesions. (omicsonline.org)
  • Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12-0.7/1000 pregnancies in Western nations. (sun.ac.za)
  • This condition occurs infrequently in humans, but when it does, this parasitic infestation can severely damage the liver and other organs as well. (livestrong.com)
  • Failure of adequate venous drainage from the liver leads to chronic passive congestion, with blood backing up in centrilobular areas. (siumed.edu)
  • Certain leukemias, including chronic myelogenous leukemia, are also now considered Myeloproliferative Neoplasms. (cancersupportcommunity.org)
  • 6 Additionally, reactive oxygen species are created in hepatocytes during alcohol metabolism and can lead to further liver damage. (abdominalkey.com)
  • We examined whether hepatocyte p38 alpha, found to inhibit liver carcinogenesis, acts similarly to IKK beta in control of ROS metabolism and cell death. (nih.gov)
  • Relating to the surgical HAI pump placement, early postoperative complications consist of arterial injury leading to hepatic artery thrombosis, inadequate perfusion of the entire liver due to the inability to identify an accessory hepatic artery, extrahepatic perfusion to the stomach or duodenum, or hematoma formation in the subcutaneous pump pocket. (wikipedia.org)
  • 2020). Laparoscopic vs. open liver resections of posterolateral liver segments - a systematic review and meta-analysis. (termedia.pl)
  • The arrays included paired nonneoplastic and neoplastic liver tissue from each patient. (aacrjournals.org)
  • These pathways complement our catalog of research reagents for the study of Liver Neoplasms, Experimental including antibodies and ELISA kits against GLUTATHIONE TRANSFERASE, GLUTATHIONE S-TRANSFERASE, GST-P, AFP, ALB. (novusbio.com)
  • Liver cysts are fluid-filled crevices or sacs in the liver. (livestrong.com)
  • Cysts in the liver may manifest because of an infection from ingesting contaminated food or liquids that contain a parasitic worm, specifically, echinococcus granulosus. (livestrong.com)