Liver Diseases, Alcoholic
Liver Cirrhosis
Fatty Liver
Liver
Liver Transplantation
End Stage Liver Disease
Liver Function Tests
Liver Cirrhosis, Alcoholic
Microsomes, Liver
Drug-Induced Liver Injury
Hepatitis, Alcoholic
Alanine Transaminase
Liver Failure
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Hepatitis, Chronic
Mitochondria, Liver
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
Hepatocytes
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Liver Failure, Acute
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Liver Cirrhosis, Biliary
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Fatty Liver, Alcoholic
Cholestasis
Hepatitis C, Chronic
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Liver Extracts
Hepatitis, Autoimmune
Hepatitis, Viral, Human
Liver Cirrhosis, Experimental
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Hepatic Encephalopathy
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Hepatitis B
Cholestasis, Intrahepatic
Aspartate Aminotransferases
Liver Abscess
Bile Ducts
alpha 1-Antitrypsin Deficiency
Hepacivirus
Liver, Artificial
Cholangitis, Sclerosing
Kupffer Cells
Hypertension, Portal
gamma-Glutamyltransferase
Severity of Illness Index
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Biopsy
Carbon Tetrachloride
Hepatitis B, Chronic
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Treatment Outcome
Risk Factors
Hepatic Stellate Cells
Drug-Induced Liver Injury, Chronic
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Hepatopulmonary Syndrome
A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).
Hepatitis B virus
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Hepatic Insufficiency
Cysts
Tissue and Organ Procurement
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Disease Models, Animal
Protoporphyria, Erythropoietic
An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.
Disease Progression
Lipid Metabolism
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Biliary Tract Diseases
Biliary Atresia
Elasticity Imaging Techniques
Non-invasive imaging methods based on the mechanical response of an object to a vibrational or impulsive force. It is used for determining the viscoelastic properties of tissue, and thereby differentiating soft from hard inclusions in tissue such as microcalcifications, and some cancer lesions. Most techniques use ultrasound to create the images - eliciting the response with an ultrasonic radiation force and/or recording displacements of the tissue by Doppler ultrasonography.
Hemochromatosis
A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)
Hepatolenticular Degeneration
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
Hepatorenal Syndrome
Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
Cholagogues and Choleretics
Rats, Inbred Strains
Alcoholism
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
Insulin Resistance
Cytochrome P-450 CYP2E1
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Liver Diseases, Parasitic
Keratin-18
Hepatitis B Surface Antigens
Ursodeoxycholic Acid
Bile Acids and Salts
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
Transaminases
Rats, Wistar
alpha-Fetoproteins
Esophageal and Gastric Varices
Hepatitis A
Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Bile Ducts, Intrahepatic
alpha 1-Antitrypsin
Choline Deficiency
A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Prospective Studies
Graft Survival
Hepatic Artery
Prevalence
Hepatitis B Antigens
Rats, Sprague-Dawley
Jaundice
Oxidative Stress
Tissue Donors
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Prognosis
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Bile
Postoperative Complications
Follow-Up Studies
Portal System
Hep G2 Cells
Iron Overload
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Acetaminophen
Base Sequence
Hepatitis Antibodies
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Alkaline Phosphatase
Kidney
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Gene Expression Regulation
Gastroenterology
Alcohol Drinking
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Silymarin
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Graft Rejection
Fatty Acids
Lipogenesis
Immunohistochemistry
Thioacetamide
Hepatitis D, Chronic
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Patient Selection
Fibrosis
Keratin-8
Siderosis
ROC Curve
Serum Albumin
Iron
Reverse Transcriptase Polymerase Chain Reaction
Cells, Cultured
Multivariate Analysis
Portacaval Shunt, Surgical
Isoenzymes
Egypt
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Albumins
Sensitivity and Specificity
Autoimmune Diseases
Risk Assessment
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Biopsy, Needle
Cholangitis
Prothrombin Time
Gene Expression
Bacterial Translocation
The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.
Lipid Peroxidation
Antioxidants
Phenobarbital
Hyperbilirubinemia
Flaviviridae
Alagille Syndrome
A multisystem disorder that is characterized by aplasia of intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC), and malformations in the cardiovascular system, the eyes, the vertebral column, and the facies. Major clinical features include JAUNDICE, and congenital heart disease with peripheral PULMONARY STENOSIS. Alagille syndrome may result from heterogeneous gene mutations, including mutations in JAG1 on CHROMOSOME 20 (Type 1) and NOTCH2 on CHROMOSOME 1 (Type 2).
Cholesterol
Survival Rate
Gastrointestinal Hemorrhage
Blood Coagulation Disorders
Hepatitis C Antibodies
Bile Duct Diseases
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Hepatitis B Antibodies
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Structural and functional changes in acute liver injury. (1/4731)
Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At no time are there changes in mitochondria or single membrane limited bodies in cells with intact plasmalemma, although a relative increase in cell sap may appear. In dead cells (those with plasmalemma discontinuties) crystalline deposits of calcium phosphatase may be noted. Functional changes are related to the endoplasmic reticulum and the plasma membrane. An early decrease in protein synthesis takes place; an accumulation of neutral lipid is related to this change. Later alterations in the ergastoplasmic functions (e.g., mixed function oxidation) occurs. Carbon tetrachloride is not the active agent; rather, a product of its metabolism, probably the CC1, free radical, is. The mechanisms of injury include macromolecular adduction and peroxide propagation. A third possibility includes a cascade effect with the production of secondary and tertiary products, also toxic in nature, with the ability to produce more widespread damage to intracellular structures. (+info)Various forms of chemically induced liver injury and their detection by diagnostic procedures. (2/4731)
A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)Quantitative aspects in the assessment of liver injury. (3/4731)
Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed. (+info)Assessment of hepatotoxic potential. (4/4731)
Philosophic concepts and pragmatic approaches toward improved understanding of the effect of drugs in the hepatocyte are reviewed. No set pattern of studies is advocated but rather observations are encouraged within the framework of studies that provide for varied exposure of the hepatocyte. Clinical usage should be imitated to provide earliest possible indications of toxicity in man. The need for definitive characterization through utilization of appropriate methodology derived from cross-fertilization of related disciplines is stressed. Both minimal and maximal dose effects should be established. Selected use of electron microscopy has become essential for characterizing responses of the liver to injury. The advantages of the toluidine blue-stained Epon "thick" sections are emphasized. Such observations are used to implement the utility of serial biopsies from the beagle dog prior to and during long-term study of potential hepatic injury. Examples of the critical effects of drug concentration within the hepatocyte are presented. (+info)Complement fixing hepatitis B core antigen immune complexes in the liver of patients with HBs antigen positive chronic disease. (5/4731)
One hundred and fifty-two biopsies from serologically HBsAg positive and negative patients with liver disease were studied in immunofluorescence: for the presence of the surface (HBs) and the core (HBc) antigenic determinants foeterminants of the hepatitis B virus, of immunoglobulins and complement (C) deposits, and for the capacity to fix human C. Circumstantial evidence is presented suggesting that HBc immune-complexes are a relevant feature in the establishment and progression of chronic HBSAg liver disease. C fixation by liver cells was shown in all HBC positive patients with chronic hepatitis; an active form was present in every case, except two with a persistent hepatitis, an inverse ratio of HBc to C binding fluorescence being noted between active chronic hepatitis and cirrhotic patients. HBc without C fixation was observed in only three patients in the incubation phase of infectious hepatitis. IgG deposits were often found in HBc containing, C fixing nuclei. No C binding or IgG deposits were observed in acute self-limited type B hepatitis, in serologically positive patients with normal liver or minimal histological lesions, with and without HBs cytoplasmic fluorescence in their biopsy, or in serologically negative individuals. (+info)Study of an epidemic of venoocclusive disease in India. (6/4731)
Twenty-five cases of rapidly developing ascites occurring in an epidemic form were observed in a tribal district in Central India during August 1972-May 1973. Eleven of the patients died. Six patients were brought to hospital and studied for periods of two to 17 months. Necropsy was performed on one patient who died. The clinical features suggested an outflow tract obstruction such as a Budd-Chiari-like syndrome or venoocclusive disease. Radiographic and haemodynamic studies demonstrated a combination of post and perisinusoidal blocks. Liver dysfunction was indicated by the presence of a marked bromsulphthalein retention and mild to moderate hypoalbuminaemia. Histological examination of the liver biopsies showed changes that ranged from centrizonal haemorrhagic necrosis to an extensive centrilobular fibrosis associated with central vein occlusion. The disease was apparently caused by a food toxin, and the possible nature of this is discussed. (+info)Risk of major liver resection in patients with underlying chronic liver disease: a reappraisal. (7/4731)
OBJECTIVE: To explore the relation of patient age, status of liver parenchyma, presence of markers of active hepatitis, and blood loss to subsequent death and complications in patients undergoing a similar major hepatectomy for the same disease using a standardized technique. SUMMARY BACKGROUND DATA: Major liver resection carries a high risk of postoperative liver failure in patients with chronic liver disease. However, this underlying liver disease may comprise a wide range of pathologic changes that have, in the past, not been well defined. METHODS: The nontumorous liver of 55 patients undergoing a right hepatectomy for hepatocellular carcinoma was classified according to a semiquantitative grading of fibrosis. The authors analyzed the influence of this pathologic feature and of other preoperative variables on the risk of postoperative death and complications. RESULTS: Serum bilirubin and prothrombin time increased on postoperative day 1, and their speed of recovery was influenced by the severity of fibrosis. Incidence of death from liver failure was 32% in patients with grade 4 fibrosis (cirrhosis) and 0% in patients with grade 0 to 3 fibrosis. The preoperative serum aspartate transaminase (ASAT) level ranged from 68 to 207 IU/l in patients with cirrhosis who died, compared with 20 to 62 in patients with cirrhosis who survived. CONCLUSION: A major liver resection such as a right hepatectomy may be safely performed in patients with underlying liver disease, provided no additional risk factors are present. Patients with a preoperative increase in ASAT should undergo a liver biopsy to rule out the presence of grade 4 fibrosis, which should contraindicate this resection. (+info)Predicting bone loss following orthotopic liver transplantation. (8/4731)
BACKGROUND: Hepatic osteodystrophy occurs in the majority of patients with advanced chronic liver disease with the abnormalities in bone metabolism accelerating following orthotopic liver transplantation (OLT). AIMS: To examine changes in bone mineral density (BMD) following OLT and to investigate factors that lead to bone loss. METHODS: Twelve patients had BMD (at both the lumbar spine (LS) and femoral neck (FN)) and biochemical markers measured preoperatively and for 24 months following OLT. RESULTS: BMD was low in 75% of patients prior to OLT and decreased significantly from baseline at the LS at three months and the FN at six months. BMD began to increase thereafter at both sites, approaching baseline values at the LS by 12 months. Bone formation markers, osteocalcin and procollagen type I carboxy propeptide, decreased immediately post-OLT, with a concomitant increase seen in the resorption markers pyridinoline and deoxypyridinoline. This resulted in a negative uncoupling index early post-OLT, that rebounded to positive values after six months. There was a significant correlation between the change in the uncoupling index between six and three months which preceded the increase in BMD at 12 months. The decrease in BMD recorded early post-OLT correlated with vitamin D levels at three months. CONCLUSIONS: Results suggest that increased resorption and inadequate formation are the major contributors to additional bone loss following OLT. Non-invasive biochemical markers precede later changes in BMD in this patient group following OLT and may have a role in investigating and planning intervention strategies to prevent bone loss in future studies. (+info)
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EP 2227689 A4 20110330 - BIOMARKERS FOR FATTY LIVER DISEASE AND METHODS USING THE SAME
Liver Health Month: Help Prevent Fatty Liver Disease | Conconi Family Foundation
Liver Transplant In India Information Guide.: Liver Disorders
Arteriovenous haemangioma in chronic liver disease: clinical and histopathological features of four cases - Akiyama - 2001 -...
Liver Transplant In India Information Guide.: Successful Liver Transplant Surgery for a 11 month old boy, the first of its kind...
Polycystic Liver Disease on CT - Stock Image M130/0999 - Science Photo Library
Abstract 12961: No Effect of Hepatic Impairment on the Pharmacokinetics of Serelaxin, a Recombinant Human Relaxin-2 in...
Diet For Abnormal Liver Enzymes And Elevated Liver Disorders - Diet, Nutrition, Exercise for a Healthy Life.
End stage liver disease symptoms - Herbal Active Liver Detox - May 2, 2017
Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests...
World Liver Day: Take good care of your Liver to live healthy - BREAKING NEWS SPECIAL
Observer error and sampling variability tested in evaluation of hepatitis and cirrhosis by liver biopsy<...
Overweight teenagers at higher risk of liver diseases later - Canindia News
Liver disease and protein needs.<...
Bi-directional link between fatty liver disease and cardiovascular disease | Motherhealth
Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD
Fatty liver disease diet guide - International Shia News Agency
Anna Andreasson - Stockholms universitet
Anna Andreasson - Stockholms universitet
BVHS Weekend Column: Getting the Skinny on Fatty Liver Disease - TheNBXpress.com
Evidence Mounts for the Role of Inflammation and Immune Dysregulation in Metabolic Liver Disease Related to Obesity
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease - CONVERIS Research Information System ...
Liver Disease, Liver Disease Treatment India, Liver Disease Symptoms, Liver Treatment in India, Liver Disease Hospital in India
Hepatic insufficiency synonyms, hepatic insufficiency antonyms - FreeThesaurus.com
PTINR.com | The Liver, Liver Disease and Warfarin
Possible Treatment Target Found For Main Cause Of Severe Liver Disease In Kids - Redorbit
Abnormal liver function tests: case-based discussion | GPonline
Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study |...
When is surgery indicated for polycystic liver disease (PCLD)?
Liver disease
... , or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. ... Fibrinolysis generally proceeds faster with acute liver failure and advanced stage liver disease, unlike chronic liver disease ... Model for end-stage liver disease (MELD) "Liver Diseases". MedlinePlus. MedlinePlus Encyclopedia: Liver function tests "NHS ... alcoholic fatty liver disease, cirrhosis, and liver cancer. In the earlier stages of alcoholic liver disease, fat builds up in ...
Polycystic liver disease
... can exist either as isolated polycystic liver disease (PCLD), part of autosomal dominant polycystic ... autosomal dominant polycystic kidney disease (with kidney cysts) and autosomal dominant polycystic liver disease (liver cysts ... Polycystic liver disease (PLD) usually describes the presence of multiple cysts scattered throughout normal liver tissue. PLD ... of all cases of end-stage renal disease. The much rarer autosomal-dominant polycystic liver disease will progress without any ...
Metastatic liver disease
The liver is a common site for metastatic disease because of its rich, dual blood supply (the liver receives blood via the ... "Prognosis of patients with metastatic liver disease diagnosed by liver scan". Archived from the original on 2014-01-03. ... Metastatic Liver Cancer: Tumors of the Liver: Merck Manual Home Health Handbook Treatment of metastatic liver cancer and ... Patients with Colorectal cancer will develop liver metastases during the disease Tumor emboli entering the sinusoids through ...
Fatty liver disease
There are two types of fatty liver disease: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease. NAFLD is ... "Fatty Liver Disease in Birds". Animal House of Chicago. Retrieved 29 December 2020. "Fatty Liver Disease in Lizards". Wag!. ... Fatty liver disease (FLD), also known as hepatic steatosis, is a condition where excess fat builds up in the liver. Often there ... Fatty liver can also be induced in ruminants such as sheep by a high caloric diet. "Nonalcoholic Fatty Liver Disease & NASH". ...
Alcoholic liver disease
... (ALD), also called alcohol-related liver disease (ARLD), is a term that encompasses the liver ... It is the major cause of liver disease in Western countries. Although steatosis (fatty liver disease) will develop in any ... It is usually not until development of advanced liver disease that stigmata of chronic liver disease become apparent. Early ALD ... Sex: Women are twice as susceptible to alcohol-related liver disease, and may develop alcoholic liver disease with shorter ...
Chronic liver disease
"Chronic liver disease" refers to disease of the liver which lasts over a period of six months. It consists of a wide range of ... Chronic liver disease in the clinical context is a disease process of the liver that involves a process of progressive ... Testing for chronic liver disease involves blood tests, imaging including ultrasound, and a biopsy of the liver. The liver ... Chronic Liver Disease Causes, Symptoms And Treatment - 27/01/2007 Liver Disease Archived 2010-01-31 at the Wayback Machine ...
Children's Liver Disease Foundation
... (CLDF) is a UK charity taking action against the effects of childhood liver disease, ... a sign of possible liver disease. Children's Liver Disease Foundation website (Articles lacking in-text citations from October ... The name was later changed to Children's Liver Disease Foundation. Today the charity works in four main areas, support of ... CLDF provides support to families and young people affected by childhood liver disease, including an 'on-call' telephone and ...
American Association for the Study of Liver Diseases
Liver Transplantation and Clinical Liver Disease. Clinical Liver Disease is a multimedia review journal. It is clinical in ... Reau, Nancy (July 19, 2016). "Clinical Liver Disease, a multimedia review journal". Clinical Liver Disease. Wiley.com. doi: ... the premier journal in the field of liver disease Liver Transplantation, an official publication of AASLD Clinical Liver ... which is the largest worldwide scientific conference on liver diseases. It also conducts several regional liver disease ...
Non-alcoholic fatty liver disease
NAFLD and alcoholic liver disease are types of fatty liver disease. Obtaining a sample of the liver after excluding other ... For people with NASH and end-stage liver disease, liver failure, or liver cancer, liver transplantation is an accepted ... Non-alcoholic fatty liver disease (NAFLD), also known as metabolic (dysfunction) associated fatty liver disease (MAFLD), is ... "Obesity epidemic results in Non-Alcoholic Fatty Liver Disease (NAFLD) becoming the most common cause of liver disease in Europe ...
Pediatric end-stage liver disease
... (PELD) is a disease severity scoring system for children under 12 years of age. It is ... This score is also used by the United Network for Organ Sharing (UNOS) for prioritizing allocation of liver transplants. PELD ...
Model for End-Stage Liver Disease
The Model for End-Stage Liver Disease, or MELD, is a scoring system for assessing the severity of chronic liver disease. It was ... considering 3,437 adult liver transplant candidates with chronic liver disease who were added to the OPTN waiting list at 2A or ... The etiology of liver disease was subsequently removed from the model because it posed difficulties such as how to categorize ... patients with multiple causes of liver disease. Modification of the MELD score by excluding etiology of liver disease did not ...
Sleisenger and Fordtran's Gastrointestinal and Liver Disease
... is a textbook on hepatology and gastroenterology for medical ... de Villiers, Willem JS (March 2007). "Sleisenger and Fordtran's Gastrointestinal and Liver Disease". Shock. 27 (3): 344. doi: ... Ghent, C.N. (3 September 1998). "Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, diagnosis, ... Greenberger, Norton (October 2007). "Sleisenger and Fordtran's Gastrointestinal Liver Disease". Gastroenterology. 133 (4): 1387 ...
United Kingdom Model for End-Stage Liver Disease
Model for End-Stage Liver Disease MELD-Plus Pediatric End-Stage Liver Disease Milan criteria Child-Pugh score "Liver Transplant ... Asrani SK, Kim WR (May 2010). "Organ allocation for chronic liver disease: model for end-stage liver disease and beyond". Curr ... Liver Disease or UKELD is a medical scoring system used to predict the prognosis of patients with chronic liver disease. It is ... February 2008). "Selection of patients for liver transplantation and allocation of donated livers in the UK". Gut. 57 (2): 252- ...
Haemobilia
Sargent, Suzanne (2009). Liver Diseases; An essential guide for nurses and healthcare professionals. Wiley-Blackwell. pp. 24-25 ... It should be considered in upper abdominal pain presenting with UGI bleeding especially when there is a history of liver injury ... and liver biopsy. Combination of EGD, CT scan and angiography depending on clinical situation, bearing in mind that haemobilia ... the Anatomy of the liver), 1654 (Cambridge Wellcome texts and documents). Cambridge: Wellcome Unit for the History of Medicine ...
Acute liver failure
... of liver disease, and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The ... Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure. Acute liver failure also ... in a patient without known prior liver disease".page 1557 The diagnosis of acute liver failure is based on physical exam, ... Polson, J; Lee, WM; American Association for the Study of Liver, Disease (May 2005). "AASLD position paper: the management of ...
Crohn's disease
Liver involvement of Crohn's disease can include cirrhosis and steatosis. Nonalcoholic fatty liver disease (Nonalcoholic ... National Research Council (2003). "Johne's Disease and Crohn's Disease". Diagnosis and Control of Johne's Disease. Washington, ... in Crohn's disease correlates with enhanced TNF-alpha secretion". Digestive and Liver Disease. 39 (5): 445-51. doi:10.1016/j. ... inflammatory bowel disease, and colon cancer". Seminars in Liver Disease. 26 (1): 31-41. doi:10.1055/s-2006-933561. PMID ...
Caffeine
... can accumulate in individuals with severe liver disease, increasing its half-life. A 2011 review found that increased ... Muriel P, Arauz J (July 2010). "Coffee and liver diseases". Fitoterapia. 81 (5): 297-305. doi:10.1016/j.fitote.2009.10.003. ... Rodopoulos N, Wisén O, Norman A (May 1995). "Caffeine metabolism in patients with chronic liver disease". Scandinavian Journal ... It may confer a modest protective effect against some diseases, including Parkinson's disease. Some people experience sleep ...
Gastroesophageal reflux disease
... for treatment of gastro-oesphageal reflux disease". Digestive and Liver Disease. 44 (8): 631-5. doi:10.1016/j.dld.2012.03.019. ... Gastroesophageal reflux disease (GERD) or gastro-oesophageal reflux disease (GORD) is one of the upper gastrointestinal chronic ... October 2004). "There is no difference in the disease severity of gastro-oesophageal reflux disease between patients infected ... Granderath, Frank Alexander; Kamolz, Thomas; Pointner, Rudolph (2006). Gastroesophageal Reflux Disease: Principles of Disease, ...
Vulimiri Ramalingaswami
Ramalingaswami, V.; Nayak, N. C. (1970). "Liver disease in India". Progress in Liver Diseases. 3: 222-235. PMID 4910369. ...
Infections associated with diseases
Digestive and Liver Disease. 37 (4): 219-26. doi:10.1016/j.dld.2005.01.003. PMID 15788203. Carbone, Antonino; Gloghini, ... Lists of diseases, Infectious diseases, Infectious causes of cancer, Diseases and disorders, Inflammations). ... Diseases may also be multifactorial, requiring multiple factors to induce disease. For example: in a murine model, Crohn's ... The history of infection and disease were observed in the 1800s and related to the one of the tick-borne diseases, Rocky ...
Organomegaly
Page 256 in Neil Kaplowitz (1996). Liver and Biliary Diseases. Williams & Wilkins. ISBN 9780683045451. Justin, M; Zaman, S; ... Page 1964 in: Florian Lang (2009). Encyclopedia of Molecular Mechanisms of Disease. Springer Science & Business Media. ISBN ... Chapter: Ear, Nose and Throat Histopathology in L. Michaels (1987). Normal Anatomy, Histology; Inflammatory Diseases. Springer ... Examples of visceromegaly are enlarged liver (hepatomegaly), spleen (splenomegaly), stomach, kidneys, and pancreas. Values ...
Stimulant
Muriel P, Arauz J (2010). "Coffee and liver diseases". Fitoterapia. 81 (5): 297-305. doi:10.1016/j.fitote.2009.10.003. PMID ... It may protect people from liver cirrhosis. There is no evidence that coffee stunts a child's growth. Caffeine may increase the ... Stimulants produce a fast-acting and pronounced but transient and short-lived mood lift. In relation to this, they are ... Moderate coffee consumption may decrease the risk of cardiovascular disease, and it may somewhat reduce the risk of type 2 ...
Inflammatory bowel disease
... inflammatory bowel disease, and colon cancer". Seminars in Liver Disease. 26 (1): 31-41. doi:10.1055/s-2006-933561. PMID ... Inflammatory bowel disease-22 World Inflammatory Bowel Disease Day GBD 2015 Disease and Injury Incidence and Prevalence ... The chief types of inflammatory bowel disease are Crohn's disease and ulcerative colitis (UC). Inflammatory bowel diseases fall ... Liver function tests are often elevated in inflammatory bowel disease, and are often mild and generally return spontaneously to ...
Epidemiology of Hepatitis D
The residual prevalence of chronic hepatitis D in HBV liver diseases in Western Europe is, as of 2010, between 4.5% and 10%, ... Patients with advanced HBV liver disease are the most suitable category of HBV carriers to determine the epidemiology and real ... In Asia up to 2015, the highest prevalences of chronic HDV liver disease were reported in Pakistan, Iran, Tajikistan, and ... Smedile, A; Rizzetto, M; Gerin, J (February 1994). "Advances in hepatitis D virus biology and disease". Progress in Liver ...
Iron overload
Hemochromatosis may present with the following clinical syndromes: liver: chronic liver disease and cirrhosis of the liver. ... liver disease, kidney disease, and cancer. Also, total iron binding capacity may be low, but can also be normal. In males and ... and family history of liver disease, additional evaluation of liver iron concentration is indicated. In this case, diagnosis of ... Maddrey, Willis C.; Schiff, Eugene R.; Sorrell, Michael F. (2007). Schiff's diseases of the liver. Hagerstwon, MD: Lippincott ...
Nephronophthisis
Murray, Karen F.; Larson, Anne M. (2010-07-23). Fibrocystic Diseases of the Liver. Springer Science & Business Media. ISBN ... Other known ciliopathies include primary ciliary dyskinesia, Bardet-Biedl syndrome, polycystic kidney and liver disease, ... eds.). Genetic Diseases of the Kidney. Academic Press. pp. 425-46. ISBN 978-0-08-092427-4. Simms, Roslyn J.; Hynes, Ann Marie; ... It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion and, ...
Gut microbiota
Dysbiosis in the gut flora has been linked with the development of cirrhosis and non-alcoholic fatty liver disease. Some genera ... Coppa, G.V; Zampini, L; Galeazzi, T; Gabrielli, O (2006). "Prebiotics in human milk: A review". Digestive and Liver Disease. 38 ... The gut-brain-liver axis and gut microbiota composition can regulate the glucose homeostasis in the liver and provide potential ... Minemura, Masami (2015). "Gut microbiota and liver diseases". World Journal of Gastroenterology. 21 (6): 1691-702. doi:10.3748/ ...
Budd-Chiari syndrome
... at Who Named It? Budd G (1845). On diseases of the liver. London: John Churchill. p. 135. Brit Lib. ... Liver transplantation is an effective treatment for Budd-Chiari. It is generally reserved for patients with fulminant liver ... liver enlargement, enlargement of the spleen, fluid accumulation within the peritoneal cavity, elevated liver enzymes, and ... Liver cell death and severe lactic acidosis may be present as well. Caudate lobe enlargement is often present. The majority of ...
Mycophenolic acid
Schiff ER, Maddrey WC, Sorrell MF (2011). Schiff's Diseases of the Liver. John Wiley & Sons. p. PT3219. ISBN 978-1-119-95048-6 ... Specifically it is used following kidney, heart, and liver transplantation. It can be given by mouth or by injection into a ... Mycophenolate sodium has also been used for the prevention of rejection in liver, heart, or lung transplants in children older ... In addition the FDA is investigating[when?] 16 people that developed a rare neurological disease while taking the drug. This is ...
Yellow fever
Talwani R, Gilliam BL, Howell C (February 2011). "Infectious diseases and the liver". Clinics in Liver Disease. 15 (1): 111-130 ... Mitchell misdiagnosed the disease that he observed and treated, and the disease was probably Weil's disease or hepatitis. ... Nearly a billion people live in an area of the world where the disease is common. It is common in tropical areas of the ... Wikipedia infectious disease articles ready to translate, Tropical diseases, Vaccine-preventable diseases). ...
Wolfgang Fink
Living people, California Institute of Technology faculty, 21st-century German physicists, Theoretical physicists, Year of ... to develop an implantable microelectronic retinal device that restores useful vision to people blinded by retinal diseases ( ...
Yee-Sin Leo
Living people, Year of birth missing (living people), Singaporean women scientists, Singaporean infectious disease physicians, ... Leo is the executive director of the National Centre for Infectious Diseases and researches emerging infectious diseases. She ... but after a chance encounter with infectious disease specialist David Allen she became more interested in infectious diseases. ... She was one of the first doctors to be trained in infectious diseases in Singapore. In 1992 Leo worked as a clinical fellow in ...
Deaths in December 2014
The Nine Lives of Fritz the Cat), chronic obstructive pulmonary disease. Laszlo Varga, 89, Hungarian-born American cellist. ... Hasta luego, maestro Joan Barril (in Spanish) Ina Bauer gone, but move lives on Professor Anthony Birch: Political scientist ... Larry Auerbach, 91, American television director (Love of Life, One Life to Live, As the World Turns), complications of ... Joseph Sargent, 89, American film director (The Taking of Pelham One Two Three, MacArthur, Jaws: The Revenge), heart disease. ...
Anton Chekhov
But on these conditions: everything must be as it has been hitherto-that is, she must live in Moscow while I live in the ... Chekhov died on 15 July 1904 at the age of 44 after a long fight with tuberculosis, the same disease that killed his brother. ... The family lived in poverty in Moscow. Chekhov's mother was physically and emotionally broken by the experience. Chekhov was ... Unexpectedly though, they gradually fall deeply in love and end up risking scandal and the security of their family lives. The ...
Chilean art
With most of them coming from humble beginnings, they made little money from painting and mostly lived in poverty, causing many ... to die young from diseases such as malaria and tuberculosis. The 13 Generation emerged from the country's poorest ... The cultural references varied depending on the area where the people lived. Northern cultures, like the Diaguita, preferred ...
Del Crandall
He was 91, and had Parkinson's disease, heart disease, and suffered several strokes prior to his death. Del Crandall at ... Crandall was the last living player to have played for the Boston Braves. Crandall was born in Ontario, California, on March 5 ... From August 2020 until his death, Crandall was the last living Boston Brave, following the death of Bert Thiel on July 31. ... Deaths from Parkinson's disease, Evansville Braves players, Gold Glove Award winners, Major League Baseball broadcasters, Major ...
Hanna Helena Chrzanowska
The Positio was presented to Rome for further evaluation in 2011 and Pope Francis recognized that she had lived a life of ... Chrzanowska succumbed to the disease on 29 April 1973 in her apartment at 4:00am and the Cardinal Archbishop of Krakow Karol ... In 1966 she was diagnosed with cancer and despite several operations (one being on 13 December 1966) the disease spread. ...
Avid Radiopharmaceuticals
Since the disease was first described by Alois Alzheimer in 1906, the only certain way to determine if a person indeed had the ... firms as a means of determining the ability of the drugs to reduce the buildup of amyloid protein in the brains of living ... The findings will require review by the FDA to confirm its reliability as a means of diagnosing the disease. If confirmed, the ... Doctors must diagnose the disease in patients with memory loss and dementia based on symptoms, and as many as 20% of patients ...
Thomas Lodge
Lodge while practising medicine in London lived first in Warwick Lane, afterwards in Lambert Hill, and finally in Old Fish ... disease), People from West Ham, Alumni of Trinity College, Oxford, 16th-century English poets, English Renaissance dramatists, ...
Black River (settlement)
During the War of the Spanish Succession early in the 18th century, there were reports of British settlers living on the ... but Spanish colonial authorities recaptured the fort there after its garrison was reduced by tropical disease. Most of Black ... and 3,000 armed Miskito and zambos living nearby, along with 30 British regulars. A report prepared by Hodgson in 1757 numbered ... where the Spanish garrison had been significantly reduced by disease. Lawrie and Despard regained control of Black River, ...
Benji (1974 film)
Benji, a stray dog who lives in an abandoned house on the outskirts of a small town, sets about his daily ritual of visiting ... Chapman tells his despondent children that Benji carries diseases and forbids them from keeping him as a pet in spite of ...
Lee Jin-hyuk
As a child, Lee had an open heart surgery to repair his cardiac valve that did not function properly due to a heart disease. ... Kim Min-ji (March 4, 2021). "려욱·이진혁→산다라박, 라이브 시트콤 '온에어-비밀계약' 라인업 확" [Ryeowook, Jinhyuk Lee → Sandara Park, live sitcom 'On Air- ... Living people, 1996 births, 21st-century South Korean male singers, South Korean male idols, Produce 101 contestants, K-pop ... 2019 and the showcase was also broadcast live through Vlive app. Lee released his second extended play Splash! on June 30, 2020 ...
Lane Seminary
There lived in this same family a young man, a slave, who was in the habit of running away. He returned one time after a week's ... First of all, the disease rates among the new colonists were the highest since accurate record-keeping began. Over 50% of them ... Ten had lived in slave states. One, Birney, had been an agent of the Colonization Society. Arguments addressing the first ... These students lived, studied, and taught the local black community. The rebels also preached in local black and white churches ...
Ereshkigal
... threatening to open the gates of the underworld and allow the spirits of the dead to swarm the world of the living if her ... had an entourage of minor war gods and disease demons instead. The idea of Nergal and Ereshkigal as a couple likely developed ... "the two deities seem to reunite and live happily ever after," and the myth concludes with the line "they impetuously entered ...
Synthetic virology
With synthetic live viruses, it is not whole viruses that are synthesized but rather their genome at first, both in the case of ... Bioterrorism Disease X Cello, Jeronimo; Paul, Aniko V.; Wimmer, Eckard (2002-08-09). "Chemical Synthesis of Poliovirus cDNA: ... a new opportunity to understand and prevent viral disease". Nature Biotechnology. 27 (12): 1163-72. doi:10.1038/nbt.1593. ISSN ...
Mangelwurzel
The food shortages in Europe after World War I caused great hardships, including cases of mangel-wurzel disease, as relief ... which afflicted those who lived solely on beets. Mohammadi, Dara (2017-01-01). "The twists and turns of colorectal cancer ... Relief workers invented names for things they had never seen before, such as the mangel-wurzel disease, ...
Noah S. Sweat
He died in 1996 in Alcorn County, Mississippi after a long battle with Parkinson's disease. The "whiskey speech", delivered on ... gracious living into the bottomless pit of degradation, and despair, and shame and helplessness, and hopelessness, then ...
Simona Senoner
Neurological disease deaths in Germany, Infectious disease deaths in Germany, Deaths from meningitis, 20th-century Italian ... Senoner was born in Bolzano, in the province of South Tyrol, and lived in Santa Cristina Gherdëina, in the Ladin-speaking ...
February 1909
Bills prohibiting Asian-Americans from serving on corporate boards or from living outside districts both failed. The ... "serves as the cesspool of poisons of the body and becomes the culture bed of certain diseases" and persuaded a surgeon to ...
Julius Stumpf
"THE MAN WHO SAVED ONE MILLION LIVES". The Geological Society of America. Archived from the original on January 19, 2010. Stumpf ... ulcers of the tibia and the skin disease eczema. He worked at the University of Würzburg. Reinbacher, W. Rudolf. " ...
Khecarī mudrā
That which enables living beings to acquire Self-realization in all the states of the embodied ones is Mudrā.... So Khecarī ... "Yogic posture which bestows spiritual attainment and enables one to overcome disease and death." He explains that "Kha denotes ... lives for 100,000 years. A tantric Saiva text, the Mālinīvijayottaratantra, warns: [If] his mouth fills with a slightly salty ...
Deborah Squash
Many people initially lived in temporary housing - such as pit houses, tents, or huts. Although there was promise of land, most ... The destiny of the remaining seven people is unknown; they could have found freedom or died of disease during the war. It is ... She is listed as Deborah Lynch, living in a house with Mr. Lynch. In the same house was Neil Robinson, who is believed to have ... Peter Lynch, a farmer lived along Roseway River in 1786 and 1787. He was identified as one of the slaveholders in the Shelburne ...
Battle of Sio
These troops lived to fight the Americans at the Battle of Driniumor River later in the year, and the Australians in the Aitape ... Hundreds of Japanese soldiers were killed; thousands more died from disease, malnutrition, exhaustion and suicide. The Allies ... Japanese casualties were 420 killed and 136 found dead, victims of disease, malnutrition, and suicide. Only six Japanese ... resulting in disease, malnutrition, and privation for the Japanese soldiers. Meanwhile, the Allied supply system grappled with ...
American cockroach
... es generally live in moist areas but can survive in dry areas if they have access to water. They prefer high ... Cockroaches can pick up disease-causing bacteria, such as Salmonella, on their legs and later deposit them on foods and cause ... After hatching, the nymphs feed and undergo a series of 13 moultings (or ecdysis). Adult cockroaches can live up to an ... In residential areas outside the tropics, these cockroaches live in basements and sewers and may move outdoors into yards ...
Robert Adams (spiritual teacher)
And when they'd come by they would say,"Where does the sage live?" and he would say, "he's gone, he doesn't live here anymore ... In the 1980s Adams developed Parkinson's disease, which forced him to settle in one location and receive the appropriate care. ... In those days there were many people or sadhus living in the other caves above him. ...Now the sadhus lived above him about ... His claims of living in Arthur Osborne's house have been questioned by Katya Osborne and Michael James and found to be likely ...
Paul Kangas
Cohen, Patricia (March 2, 2017). "Paul Kangas, 79, Anchor Who Brought Stocks Into Living Rooms, Dies". The New York Times. p. ... He died on February 28, 2017, in Miami, Florida, from complications of Parkinson's disease and prostate cancer, aged 79. In ...
Boolarra, Victoria
One impact that has been well recorded is the transmission of disease. Goldfish ulcer disease (GUD) is a bacterial disease ... Prior to colonisation, the Boolarra area was part of the country of the Gunaikurnai people, who had lived there for over 20,000 ... However, there has been one recorded outbreak of the disease in a silver perch fish farm in NSW. Trout are at high risk of ...
Gali Baharav-Miara
In 2002 he was diagnosed with ALS and has been coping with the disease ever since. The couple has three sons and lives in ... In tort cases filed by Palestinians living in the Occupied Territories against the state, she has led a policy of opposition to ...
Cervical cancer
Dunne EF, Park IU (December 2013). "HPV and HPV-associated diseases". Infectious Disease Clinics of North America. 27 (4): 765- ... Figures suggest that cervical screening is saving 5,000 lives each year in the UK by preventing cervical cancer. About 1,000 ... Papillomavirus-associated diseases, Sexually transmitted diseases and infections, Wikipedia medicine articles ready to ... In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere. Symptoms of advanced cervical cancer may ...
Human geography
Development geography is the study of the Earth's geography with reference to the standard of living and the quality of life of ... This is a sub-discipline of human geography, researching how and why diseases are spread and contained. Historical geography is ... disease, and health care. Health geography deals with the spatial relations and patterns between people and the environment. ...
Living Well with Sickle Cell Disease | CDC
... or someone you know with sickle cell disease, stay as healthy as possible. ... People with sickle cell disease can live full lives and enjoy most of the activities that other people do. The following tips ... Sickle cell disease is a complex disease. Good quality medical care from doctors and nurses who know a lot about the disease ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Alzheimer's Association | Alzheimer's Disease & Dementia Help
... information on Alzheimers disease and dementia symptoms, diagnosis, stages, treatment, care and support resources. ... Whether you are living with Alzheimers or caring for someone with the disease, information and resources are available. ... Understanding Alzheimers Disease. Alzheimers is the most common form of dementia. It causes problems with memory, thinking ... Phase 3 clinicial trial results show that this treatment can meaningfully change the course of the disease for people in the ...
Liver Disease | MedlinePlus
Know your risk and what you can do to prevent liver problems. ... Get the facts about liver diseases, such as hepatitis, cancer, ... 25 Ways to Love Your Liver Health (American Liver Foundation) * Fighting Fatty Liver: Steps Against a Silent Disease (National ... Inherited diseases, such as hemochromatosis and Wilson disease. Symptoms of liver disease can vary, but they often include ... Tests such as imaging tests and liver function tests can check for liver damage and help to diagnose liver diseases. ...
The Liver Meeting | AASLD
... discuss new developments in liver treatment and transplantation, and network with leading experts in the field of hepatology. ... The Liver Meeting brings together clinicians, associates, and scientists from around the world to exchange information on the ... Specialists who diagnose and treat liver disease, including gastroenterologists, surgeons, clinical pathologists, ... Attendees of The Liver Meeting and The Liver Meeting Digital Experience can claim enduring and live credits by logging into the ...
Research related to liver diseases
Pediatric Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) comprises a cluster of differentially graded liver diseases ranging from intrahepatic ... Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a multicluster disease ranging from intrahepatic simple steatosis ... The Importance of Noninvasive Screening in Non-Alcoholic Fatty Liver Disease 0.5 CME / ABIM MOC Credits Clinical Review ... Intercept Tumbles on Concerns Over Prospects of Fatty Liver Disease Drug * Guidelines for Kids With Obesity: Family and ...
Symptoms of Liver Disease in Cats - Petfinder
Learn about the symptoms of liver disease in cats here. ... The indicators of liver disease in cats can be a bit ambiguous ... because they are similar to symptoms of many other diseases and illnesses. ... Symptoms of Liver Disease in Cats. The indicators of liver disease in cats can be a bit ambiguous because they are similar to ... Cats with Liver Disease Find out what causes liver disease in cats and how to prevent it. ...
Research related to liver diseases
Liver Disease
... - Sharing our stories on preparing for and responding to public health events ... Tags Hepatitis A, Hepatitis B, Liver Cancer, Liver Disease, Liver Failure, Viral Hepatitis ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
Evidence of Toxicant-associated Fatty Liver Disease in WTC Responders - WTC Health Program Research Gateway
A WTC Liver Disease registry will be established to collect data about the impact of liver disease on quality of life and other ... and liver cancer. The findings will provide unprecedented detail about these occupational liver diseases, helping to inform ... who have evidence of toxicant-associated fatty liver disease (TAFLD) ...
Plague from Eating Raw Camel Liver - Volume 11, Number 9-September 2005 - Emerging Infectious Diseases journal - CDC
Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... Saeed, A. A., Al-Hamdan, N. A., & Fontaine, R. E. (2005). Plague from Eating Raw Camel Liver. Emerging Infectious Diseases, 11( ... Plague from Eating Raw Camel Liver. Emerging Infectious Diseases. 2005;11(9):1456-1457. doi:10.3201/eid1109.050081.. ... Y. pestis was isolated from the blood and liver of live jirds collected from the camel corral and from fleas (Xenopsylla ...
Purified Anthocyanin and Nonalcoholic Fatty Liver Disease - Full Text View - ClinicalTrials.gov
Liver Diseases. Fatty Liver. Non-alcoholic Fatty Liver Disease. Digestive System Diseases. ... MedlinePlus Genetics related topics: Non-alcoholic fatty liver disease MedlinePlus related topics: Fatty Liver Disease Liver ... Condition or disease Intervention/treatment Phase Nonalcoholic Fatty Liver Disease Dietary Supplement: Anthocyanin Dietary ... Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease. Am J Clin Nutr ...
Cytokines in alcoholic liver disease
Cytokines are low-molecular-weight mediators of cellular communication produced by multiple cell types in the liver, with the ... metabolic complications in alcoholic liver disease and probably play a role in the liver injury of alcoholic liver disease. Two ... Cytokines in alcoholic liver disease Semin Liver Dis. 1999;19(2):205-19. doi: 10.1055/s-2007-1007110. ... Cytotoxic cytokines likely induce liver cell death by both necrosis and apoptosis in alcoholic liver disease. Anticytokine ...
Abnormal Serum Protein in Parenchymatous Liver Diseases | Nature
SEVERAL colloidal serum reactions have been proposed during recent years for revealing damage of the liver parenchyme : the ... FISCHER, A., SELLEI, C. & BRETÁN, M. Abnormal Serum Protein in Parenchymatous Liver Diseases. Nature 162, 1002 (1948). https:// ... SEVERAL colloidal serum reactions have been proposed during recent years for revealing damage of the liver parenchyme : the ... Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in ...
Classification of Liver Diseases Using Intelligent Techniques
Liver diseases are the leading cause of deaths in most of the countries. Patients with liver disease have been steadily ... "Identifying a liver patient in the early stages of the disease (i.e., even minor liver damage) is difficult. Early detection of ... Classification of Liver Diseases Using Intelligent Techniques. EasyChair Preprint no. 5451. 7 pages•Date: May 4, 2021. ... Prolonged drinking habits are directly attributed in the linkage of an increased risk of developing various liver diseases that ...
Intestinal Fungi Worsen Alcoholic Liver Disease
Liver cirrhosis is the 12th leading cause of mortality worldwide and approximately half of those deaths are due to alcohol ... Intestinal Fungi Worsen Alcoholic Liver Disease. Reducing intestinal fungi slowed disease progression in mice. ... Chronic inflammation kills liver cells and ultimately promotes alcoholic liver disease. But the researchers were able to ... Mycology Addiction Liver Hepatology Alcohol alcoholic liver disease Alcoholism Microbiome Fungi Antifungal ...
Obesity Could Be Infectious | Fatty Liver Disease | Live Science
Moreover, it may be possible for these diseases to spread between individuals via microbes, at least in ... Alterations in gut microbes may increase the susceptibility to obesity and fatty liver disease. ... Previously, if two family members living in the same household both developed liver disease or became obese, people would have ... We normally live in symbiosis with the bacteria in our guts, but in the study, the number of "bad," disease-associated bacteria ...
Katherine Bishop is fundraising for Children's Liver Disease Foundation
ATP8B1 Gene Sequencing | Liver Disease Test Catalog
Cystic Disease of the Liver / Kidney Panel by Next-Generation Sequencing. *Gilbert and Crigler-Najjar Syndrome (UGT1A1 Gene ... Download Heritable Liver Disease requisition.. References. Van der Woerd, W.L., S.W.C. van Mil, et al. (2010) "Familial ... If the patient has received a liver transplant or recent blood transfusion, donor DNA may be present in the blood along with ... Disease. Progressive familial intrahepatic cholestasis 1, benign recurrent intrahepatic cholestasis 1. Description. Mutations ...
Chronic Liver Disease in Dogs
Causes of Canine Liver Disease. Liver disease in dogs can occur for a number of reasons. Bacterial and viral infections of the ... Symptoms of Chronic Liver Disease in Dogs. The initial symptoms of canine liver disease are often vague. They usually include ... As liver disease progresses, scar tissue forms in the liver, leading to a condition known as cirrhosis, or chronic liver ... Accumulation of copper in the liver, caused by copper storage disease. Often, if liver disease is caught and treated early ...
Alpha-1 Liver Disease Treatment
The cirrhosis associated with adult Alpha-1 liver disease should be treated the same as cirrhosis of any cause. ... How does Alpha-1 liver disease affect my life expectancy?. If you have one Z Alpha-1 gene and no liver disease, you have a ... A quarter of people with two Z Alpha-1 genes will develop liver disease at some point in their lives. If the Alpha-1 liver ... What is the treatment for Alpha-1 liver disease?. The cirrhosis associated with adult Alpha-1 liver disease should be treated ...
Liver disease: Study links drinking any coffee with lower risk
... and having a lower risk of liver problems. ... Liver disease and a welcome study. Worldwide, liver disease ... the sample contained 3,600 diagnoses of chronic liver disease, 5,439 cases of chronic liver disease or fatty liver disease, and ... A large new study has now found that coffee of all kinds lowers the risk of chronic liver disease, fatty liver disease, liver ... Their risk of developing either chronic liver disease or chronic liver or fatty liver disease was reduced by 35%, of developing ...
Articles, tagged with "chronic liver disease"
Liver cirrhosis lab values are used to diagnose what stage a persons liver disease is in. Here are some of the blood tests and ... Cirrhosis is a medical condition that is attributed to a chronic liver disease that results in severe liver damage. The damage ... Chronic liver disease is the tenth leading cause of death in the United States with over 25,000 deaths annually, according to ... How to Manage Chronic Liver Diseases with Natural Remedies. 23rd March 2010 ...
Liver disease, hepatitis and HIV | aidsmap
Symptoms of liver disease. In the early stages of liver disease, there may not be any obvious symptoms. Once there is some ... The build-up of fat in the liver, known as fatty liver disease or steatosis, can also cause liver damage. ... Treatments for liver disease vary depending on the cause. For hepatitis A, you can usually manage your own health, with support ... So the liver is important in getting rid of waste and in giving you energy. The liver also has a role in fighting infections, ...
Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD)
The Importance of Noninvasive Screening in Non-Alcoholic Fatty Liver Disease 0.5 CME / ABIM MOC Credits Clinical Review ... Approximately 25% of the global population has nonalcoholic fatty liver disease (NAFLD), a broad term that covers a range of ... Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD) - Medscape - May 27, 2022. ... A Novel Non-invasive Model for the Prediction of Advanced Liver Fibrosis in Chronic Hepatitis B Patients With NAFLD ...
Understanding the Psychiatric Aspects of Liver Disease
How liver disease can cause a build-up of toxins that can directly affect the brain, leading to a serious condition called ... In persons with advanced liver disease, such as decompensated cirrhosis or liver cancer, a liver transplant is most often ... Understanding the Psychiatric Aspects of Liver Disease By James Myhre & Dennis Sifris, MD ... The diagnosis of hepatic encephalopathy can only be made in the presence of confirmed liver disease or in persons who have ...
Liver Diseases Therapeutics Market | Industry Report, 2022
Key drivers of the market include increasing incidences of hepatocellular carcinoma and other liver diseases along with huge ... Liver diseases therapeutics market size was valued at USD 7,498.2 million in 2014. ... untapped needs of patients suffering from such diseases. ... Global liver diseases therapeutics market size was valued at ... Liver Diseases Therapeutics Market, Industry Report, 2022 GVR Report cover Liver Diseases Therapeutics Market Analysis By ...
Admissions due to alcoholic liver diseases in Scotland 2021, by age | Statista
This statistic displays the number of admissions to hospital as a result of alcoholic liver disease in Scotland in 2020/21, by ... Alcoholic liver disease deaths in England 2020, by gender and age. *Alcoholic liver disease deaths in Scotland 2020, by gender ... Chronic liver disease mortality rate in Scotland 2000-2018, by gender. *Chronic liver disease mortality rate in Scotland 2018, ... Alcoholic liver disease hospital admissions in Scotland 2020/21, by age. *Alcoholic liver disease hospital admissions in ...
Cell production could help liver disease | The University of Edinburgh
University scientists have shed light on how the liver repairs itself with research that could help develop drugs to treat ... Liver disease. Liver disease is the fifth biggest killer in the UK. ... Cell production could help liver disease. University scientists have shed light on how the liver repairs itself with research ... Liver disease is on the increase in the UK and is one of the top five killers. Increasing numbers of patients are in need of ...