Lipoxygenase
Arachidonate 5-Lipoxygenase
Arachidonate 12-Lipoxygenase
Lipoxygenase Inhibitors
Arachidonate 15-Lipoxygenase
Arachidonate Lipoxygenases
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Leukotrienes
Masoprocol
Hydroxyeicosatetraenoic Acids
5-Lipoxygenase-Activating Proteins
Arachidonic Acid
Leukotriene B4
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
Arachidonic Acids
5,8,11,14-Eicosatetraynoic Acid
Leukotriene A4
Eicosanoids
SRS-A
Lipid Peroxides
Linoleic Acid
Lipoxins
Calcimycin
Cyclooxygenase Inhibitors
Indomethacin
Chromatography, High Pressure Liquid
Soybeans
Leukotriene Antagonists
Prostaglandin-Endoperoxide Synthases
Hydroxyurea
Leukotriene C4
Neutrophils
Phospholipases A
Receptors, Leukotriene
Phospholipases A2
Caffeic Acids
Leukocytes
Leukotriene E4
Blood Platelets
Benzeneacetamides
Fatty Acids, Unsaturated
Reticulocytes
8,11,14-Eicosatrienoic Acid
Epoxide Hydrolases
Pyrazoles
Receptors, Leukotriene B4
Thromboxane B2
Oxylipins
Oxidation-Reduction
Cucumis sativus
Rabbits
Lipoxygenases
Autacoids
Quinolines
Quinacrine
Dinoprostone
Cells, Cultured
Peroxides
Stereoisomerism
Solanum tuberosum
Molecular Sequence Data
Benzoquinones
Substrate Specificity
Cyclooxygenase 2
Enzyme Activation
RNA, Messenger
5-Lipoxygenase-Activating Protein Inhibitors
Indoles
Leukotriene D4
Receptors, Eicosanoid
Gas Chromatography-Mass Spectrometry
Platelet Activating Factor
Intramolecular Oxidoreductases
Prostaglandins
Nonheme Iron Proteins
Pyrans
Umbelliferones
Isoenzymes
Zymosan
Dose-Response Relationship, Drug
Enzyme Inhibitors
Dioctyl Sulfosuccinic Acid
Anti-Inflammatory Agents, Non-Steroidal
Base Sequence
Cytosol
Prostaglandins E
Pleurisy
Gene Expression Regulation, Enzymologic
Pyrazolones
Chromatography, Thin Layer
Amino Acid Sequence
Membrane Proteins
Spectrophotometry, Ultraviolet
Macrophages
Calcium
Seeds
Cyclooxygenase 1
Cycloheptanes
Ionophores
Eicosapentaenoic Acid
Monocytes
Divinyl ether fatty acid synthesis in late blight-diseased potato leaves. (1/779)
We conducted a study of the patterns and dynamics of oxidized fatty acid derivatives (oxylipins) in potato leaves infected with the late-blight pathogen Phytophthora infestans. Two 18-carbon divinyl ether fatty acids, colneleic acid and colnelenic acid, accumulated during disease development. To date, there are no reports that such compounds have been detected in higher plants. The divinyl ether fatty acids accumulate more rapidly in potato cultivar Matilda (a cultivar with increased resistance to late blight) than in cultivar Bintje, a susceptible cultivar. Colnelenic acid reached levels of up to approximately 24 nmol (7 microgram) per g fresh weight of tissue in infected leaves. By contrast, levels of members of the jasmonic acid family did not change significantly during pathogenesis. The divinyl ethers also accumulated during the incompatible interaction of tobacco with tobacco mosaic virus. Colneleic and colnelenic acids were found to be inhibitory to P. infestans, suggesting a function in plant defense for divinyl ethers, which are unstable compounds rarely encountered in biological systems. (+info)Induction of monocyte binding to endothelial cells by MM-LDL: role of lipoxygenase metabolites. (2/779)
Treatment of human aortic endothelial cells (EC) with minimally oxidized LDL (or minimally modified LDL, MM-LDL) produces a specific pattern of endothelial cell activation distinct from that produced by LPS, tumor necrosis factor-alpha, and interleukin-1, but similar to other agents that elevate cAMP. The current studies focus on the signal transduction pathways by which MM-LDL activates EC to bind monocytes. We now demonstrate that, in addition to an elevation of cAMP, lipoxygenase products are necessary for the MM-LDL response. Treatment of EC with inhibitors of the lipoxygenase pathway, 5,8,11, 14-eicosatetraynoic acid (ETYA) or cinnamyl-3, 4-dihydroxy-alpha-cyanocinnamate (CDC), blocked monocyte binding in MM-LDL-treated EC (MM-LDL=118+/-13%; MM-LDL+ETYA=33+/-4%; MM-LDL+CDC=23+/-4% increase in monocyte binding) without reducing cAMP levels. To further investigate the role of the lipoxygenase pathway, cellular phospholipids were labeled with arachidonic acid. Treatment of cells for 4 hours with 50 to 100 microg/mL MM-LDL, but not native LDL, caused a 60% increase in arachidonate release into the medium and increased the intracellular formation of 12(S)-HETE (approximately 100% increase). There was little 15(S)-HETE present, and no increase in its levels was observed. We demonstrated that 12(S)-HETE reversed the inhibitory effect of CDC. We also observed a 70% increase in the formation of 11,12-epoxyeicosatrienoic acid (11, 12-EET) in cells treated with MM-LDL. To determine the mechanism of arachidonate release induced by MM-LDL, we examined the effects of MM-LDL on intracellular calcium levels. Treatment of EC with both native LDL and MM-LDL caused a rapid release of intracellular calcium from internal stores. However, several pieces of evidence suggest that calcium release alone does not explain the increased arachidonate release in MM-LDL-treated cells. The present studies suggest that products of 12-lipoxygenase play an important role in MM-LDL action on the induction of monocyte binding to EC. (+info)Conversion of cucumber linoleate 13-lipoxygenase to a 9-lipoxygenating species by site-directed mutagenesis. (3/779)
Multiple lipoxygenase sequence alignments and structural modeling of the enzyme/substrate interaction of the cucumber lipid body lipoxygenase suggested histidine 608 as the primary determinant of positional specificity. Replacement of this amino acid by a less-space-filling valine altered the positional specificity of this linoleate 13-lipoxygenase in favor of 9-lipoxygenation. These alterations may be explained by the fact that H608V mutation may demask the positively charged guanidino group of R758, which, in turn, may force an inverse head-to-tail orientation of the fatty acid substrate. The R758L+H608V double mutant exhibited a strongly reduced reaction rate and a random positional specificity. Trilinolein, which lacks free carboxylic groups, was oxygenated to the corresponding (13S)-hydro(pero)xy derivatives by both the wild-type enzyme and the linoleate 9-lipoxygenating H608V mutant. These data indicate the complete conversion of a linoleate 13-lipoxygenase to a 9-lipoxygenating species by a single point mutation. It is hypothesized that H608V exchange may alter the orientation of the substrate at the active site and/or its steric configuration in such a way that a stereospecific dioxygen insertion at C-9 may exclusively take place. (+info)Formation of lipoxygenase-pathway-derived aldehydes in barley leaves upon methyl jasmonate treatment. (4/779)
In barley leaves, the application of jasmonates leads to dramatic alterations of gene expression. Among the up-regulated gene products lipoxygenases occur abundantly. Here, at least four of them were identified as 13-lipoxygenases exhibiting acidic pH optima between pH 5.0 and 6.5. (13S,9Z,11E,15Z)-13-hydroxy-9,11,15-octadecatrienoic acid was found to be the main endogenous lipoxygenase-derived polyenoic fatty acid derivative indicating 13-lipoxygenase activity in vivo. Moreover, upon methyl jasmonate treatment > 78% of the fatty acid hydroperoxides are metabolized by hydroperoxide lyase activity resulting in the endogenous occurrence of volatile aldehydes. (2E)-4-Hydroxy-2-hexenal, hexanal and (3Z)- plus (2E)-hexenal were identified as 2,4-dinitro-phenylhydrazones using HPLC and identification was confirmed by GC/MS analysis. This is the first proof that (2E)-4-hydroxy-2-hexenal is formed in plants under physiological conditions. Quantification of (2E)-4-hydroxy-2-hexenal, hexanal and hexenals upon methyl jasmonate treatment of barley leaf segments revealed that hexenals were the major aldehydes peaking at 24 h after methyl jasmonate treatment. Their endogenous content increased from 1.6 nmol.g-1 fresh weight to 45 nmol.g-1 fresh weight in methyl-jasmonate-treated leaf segments, whereas (2E)-4-hydroxy-2-hexenal, peaking at 48 h of methyl jasmonate treatment increased from 9 to 15 nmol.g-1 fresh weight. Similar to the hexenals, hexanal reached its maximal amount 24 h after methyl jasmonate treatment, but increased from 0.6 to 3.0 nmol.g-1 fresh weight. In addition to the classical leaf aldehydes, (2E)-4-hydroxy-2-hexenal was detected, thereby raising the question of whether it functions in the degradation of chloroplast membrane constituents, which takes place after methyl jasmonate treatment. (+info)Cucumber cotyledon lipoxygenase during postgerminative growth. Its expression and action on lipid bodies. (5/779)
In cucumber (Cucumis sativus), high lipoxygenase-1 (LOX-1) activity has been detected in the soluble fraction prepared from cotyledons of germinating seeds, and the involvement of this enzyme in lipid turnover has been suggested (K. Matsui, M. Irie, T. Kajiwara, A. Hatanaka [1992] Plant Sci 85: 23-32; I. Fuessner, C. Wasternack, H. Kindl, H. Kuhn [1995] Proc Natl Acad Sci USA 92: 11849-11853). In this study we have investigated the expression of the gene lox-1, corresponding to the LOX-1 enzyme. LOX-1 expression is highly coordinated with that of a typical glyoxysomal enzyme, isocitrate lyase, during the postgerminative stage of cotyledon development. In contrast, although icl transcripts accumulated in tissue during in vitro senescence, no accumulation of lox-1 mRNA could be observed, suggesting that lox-1 plays a specialized role in fat mobilization. LOX-1 is also known to be a major lipid body protein. The partial peptide sequences of purified LOX-1 and lipid body LOX-1 entirely coincided with that deduced from the lox-1 cDNA sequence. The data strongly suggest that LOX-1 and lipid body LOX-1 are derived from a single gene and that LOX-1 can exist both in the cytosol and on the lipid bodies. We constructed an in vitro oxygenation system to address the mechanism of this dual localization and to investigate the action of LOX-1 on lipids in the lipid bodies. LOX-1 cannot act on the lipids in intact lipid bodies, although degradation of lipid body proteins, either during seedling growth or by treatment with trypsin, allows lipid bodies to become susceptible to LOX-1. We discuss the role of LOX-1 in fat mobilization and its mechanism of action. (+info)Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity. (6/779)
The oxidation of low density lipoproteins (LDL) has been implicated in the development of atherosclerosis. Recently, we found that polar lipids isolated from minimally oxidized LDL produced a dramatic inhibition of lecithin: cholesterol acyltransferase (LCAT) activity, suggesting that HDL-cholesterol transport may be impaired during early atherogenesis. In this study, we have identified molecular species of oxidized lipids that are potent inhibitors of LCAT activity. Treatment of LDL with soybean lipoxygenase generated small quantities of lipid hydroperoxides (20 +/- 4 nmol/mg LDL protein, n = 3); but when lipoxygenase-treated LDL (1 mg protein/ml) was recombined with the d > 1.063 g/ml fraction of human plasma, LCAT activity was rapidly inhibited (25 +/- 4 and 65 +/- 16% reductions by 1 and 3 h, respectively). As phospholipid hydroperoxides (PL-OOH) are the principal oxidation products associated with lipoxygenase-treated LDL, we directly tested whether PL-OOH inhibited plasma LCAT activity. Detailed dose-response curves revealed that as little as 0.2 and 1.0 mole % enrichment of plasma with PL-OOH produced 20 and 50% reductions in LCAT activity by 2 h, respectively. To gain insight into the mechanism of LCAT impairment, the enzyme's free cysteines (Cys31 and Cys184) and active site residues were "capped" with the reversible sulfhydryl compound, DTNB, during exposure to either minimally oxidized LDL or PL-OOH. Reversal of the DTNB "cap" after such exposures revealed that the enzyme was completely protected from both sources of peroxidized phospholipids. We, therefore, conclude that PL-OOH inhibited plasma LCAT activity by modifying the enzyme's free cysteine and/or catalytic residues. These studies are the first to suggest that PL-OOH may accelerate the atherogenic process by impairing LCAT activity. (+info)The diversity of the lipoxygenase family. Many sequence data but little information on biological significance. (7/779)
Lipoxygenases form a family of lipid peroxidising enzymes, which oxygenate free and esterified polyenoic fatty acids to the corresponding hydroperoxy derivatives. They are widely distributed in both the plant and animal kingdoms. During the last couple of years more and more lipoxygenase isoforms have been discovered but for most of them the biological significance remains unclear. This review attempts to classify the currently known mammalian lipoxygenase isoforms and critically reviews the concepts for their biological importance. (+info)When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid. (8/779)
The inclusion of uric acid in the incubation medium during copper-induced low-density lipoprotein (LDL) oxidation exerted either an antioxidant or pro-oxidant effect. The pro-oxidant effect, as mirrored by an enhanced formation of conjugated dienes, lipid peroxides, thiobarbituric acid-reactive substances and increase in negative charge, occurred when uric acid was added late during the inhibitory or lag phase and during the subsequent extensive propagation phase of copper-stimulated LDL oxidation. The pro-oxidant effect of uric acid was specific for copper-induced LDL oxidation and required the presence of copper as either Cu(I) or Cu(II). In addition, it became much more evident when the copper to LDL molar ratio was below a threshold value of approx. 50. In native LDL, the shift between the antioxidant and the pro-oxidant activities was related to the availability of lipid hydroperoxides formed during the early phases of copper-promoted LDL oxidation. The artificial enrichment of isolated LDL with alpha-tocopherol delayed the onset of the pro-oxidant activity of uric acid and also decreased the rate of stimulated lipid peroxidation. However, previous depletion of alpha-tocopherol was not a prerequisite for unmasking the pro-oxidant activity of uric acid, since this became apparent even when alpha-tocopherol was still present in significant amounts (more than 50% of the original values) in LDL. These results suggest, irrespective of the levels of endogenous alpha-tocopherol, that uric acid may enhance LDL oxidation by reducing Cu(II) to Cu(I), thus making more Cu(I) available for subsequent radical decomposition of lipid peroxides and propagation reactions. (+info)Lipoxygenase is an enzyme that catalyzes the oxidation of polyunsaturated fatty acids, particularly arachidonic acid, to produce a variety of bioactive compounds called eicosanoids. These compounds play important roles in various physiological processes, including inflammation, blood clotting, and immune responses. Lipoxygenase is found in many tissues throughout the body, including the lung, liver, and immune cells. In the medical field, lipoxygenase inhibitors are sometimes used to treat conditions such as asthma and inflammation.
Arachidonate 5-lipoxygenase (5-LOX) is an enzyme that plays a key role in the metabolism of arachidonic acid, a polyunsaturated fatty acid found in cell membranes. 5-LOX catalyzes the conversion of arachidonic acid to 5-hydroxyeicosatetraenoic acid (5-HETE), which is a precursor to other biologically active molecules such as leukotrienes. Leukotrienes are a group of inflammatory mediators that are involved in the immune response and play a role in the pathogenesis of various diseases, including asthma, allergic reactions, and inflammatory bowel disease. 5-LOX is therefore an important target for the development of anti-inflammatory drugs. In addition to its role in inflammation, 5-LOX has also been implicated in other biological processes, such as platelet aggregation and angiogenesis.
Arachidonate 12-lipoxygenase (ALOX12) is an enzyme that is involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid that is a major component of cell membranes. ALOX12 is primarily expressed in immune cells, such as neutrophils and macrophages, and plays a role in the production of inflammatory mediators, such as leukotrienes and prostaglandins. These mediators can contribute to the development of inflammation and other inflammatory-related diseases, such as asthma, rheumatoid arthritis, and cardiovascular disease. ALOX12 is also involved in the regulation of cell growth and differentiation, and has been implicated in the development of certain types of cancer.
Arachidonate 15-lipoxygenase (ALOX15) is an enzyme that is involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid that is a precursor to various eicosanoids, which are signaling molecules that play important roles in inflammation, blood clotting, and other physiological processes. ALOX15 is primarily expressed in the liver, but it is also found in other tissues, including the brain, lungs, and immune cells. The enzyme catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE), which is a potent mediator of inflammation and has been implicated in the pathogenesis of various diseases, including cardiovascular disease, asthma, and cancer. In addition to its role in the production of 15-HETE, ALOX15 has been shown to generate other eicosanoids, such as 12-hydroxyeicosatetraenoic acid (12-HETE) and epoxyeicosatrienoic acids (EETs), which have diverse biological activities. The regulation of ALOX15 activity is complex and involves multiple factors, including transcriptional and post-transcriptional mechanisms, as well as the availability of arachidonic acid and other substrates.
Arachidonate lipoxygenases (ALOs) are a group of enzymes that catalyze the oxidation of arachidonic acid, a polyunsaturated fatty acid, to produce various eicosanoids. These eicosanoids are signaling molecules that play important roles in regulating inflammation, blood pressure, and other physiological processes. There are several different types of ALOs, including 5-LOX, 12-LOX, and 15-LOX. Each type of ALO produces a different set of eicosanoids, which can have different effects on the body. In the medical field, ALOs and their products are often studied in relation to various diseases and conditions, such as asthma, cardiovascular disease, and cancer. For example, some studies have suggested that elevated levels of certain eicosanoids produced by ALOs may contribute to the development of inflammation and other symptoms associated with these conditions. As a result, drugs that target ALOs or their products are being investigated as potential treatments for these diseases.
12-Hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) is a bioactive lipid molecule that is produced from arachidonic acid (AA) by the action of the enzyme 12-lipoxygenase (12-LOX). It is a member of the eicosanoid family of signaling molecules, which are derived from polyunsaturated fatty acids and play important roles in various physiological processes, including inflammation, blood pressure regulation, and cell proliferation. 12-HETE is synthesized in a variety of tissues, including platelets, endothelial cells, and immune cells, and has been implicated in a number of pathophysiological conditions, including cardiovascular disease, cancer, and inflammatory disorders. It exerts its effects by binding to specific receptors on target cells and activating intracellular signaling pathways that regulate gene expression and cellular function. In the medical field, 12-HETE is often studied as a potential therapeutic target for the treatment of various diseases, as modulating its production and activity may help to regulate inflammation and other pathological processes. However, more research is needed to fully understand the role of 12-HETE in health and disease and to develop effective therapies that target this molecule.
Leukotrienes are a group of biologically active molecules that are produced by leukocytes (white blood cells) in response to inflammation. They are synthesized from arachidonic acid, which is an essential fatty acid found in cell membranes. There are several different types of leukotrienes, including leukotriene A4 (LTA4), leukotriene B4 (LTB4), leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4). These molecules have a variety of effects on the body, including: 1. Constricting blood vessels: Leukotrienes can cause blood vessels to narrow, which can increase blood pressure and contribute to inflammation. 2. Recruiting immune cells: Leukotrienes can attract immune cells to the site of inflammation, which can help to fight off infections. 3. Increasing mucus production: Leukotrienes can stimulate the production of mucus in the respiratory tract, which can lead to symptoms such as coughing and wheezing. 4. Aggravating allergic reactions: Leukotrienes can worsen allergic reactions by increasing inflammation and mucus production. Leukotrienes are involved in a number of different medical conditions, including asthma, allergic rhinitis, and chronic obstructive pulmonary disease (COPD). They are also involved in the development of certain types of cancer, such as lung cancer and colon cancer. Medications that block the production or action of leukotrienes are used to treat these conditions.
Masoprocol is a medication that is used to treat certain types of stomach ulcers. It is a proton pump inhibitor, which means that it works by reducing the amount of acid that is produced by the stomach. This can help to reduce the pain and inflammation associated with ulcers, and can also help to prevent the ulcers from getting worse. Masoprocol is usually taken by mouth, and it is available in both tablet and capsule form. It is important to follow the instructions of your healthcare provider when taking this medication, as it can have side effects and may interact with other medications.
Hydroxyeicosatetraenoic acids (HETEs) are a group of bioactive lipids that are derived from the metabolism of arachidonic acid (AA) by enzymes called lipoxygenases. HETEs are involved in various physiological processes, including inflammation, blood pressure regulation, and blood clotting. There are several different HETEs, including 5-hydroxyeicosatetraenoic acid (5-HETE), 12-hydroxyeicosatetraenoic acid (12-HETE), and 15-hydroxyeicosatetraenoic acid (15-HETE). These compounds are produced by the action of lipoxygenases on AA, which is a polyunsaturated fatty acid that is abundant in cell membranes. HETEs can act as signaling molecules, binding to specific receptors on the surface of cells and triggering a variety of cellular responses. For example, 5-HETE has been shown to promote the proliferation of smooth muscle cells, which can contribute to the development of atherosclerosis. 12-HETE has been implicated in the regulation of blood pressure, while 15-HETE has been linked to the formation of blood clots. Overall, HETEs play important roles in many physiological processes, and their dysregulation has been implicated in a variety of diseases, including cardiovascular disease, cancer, and inflammatory disorders.
5-Lipoxygenase-Activating Proteins (5-LOX-APs) are a family of proteins that activate the enzyme 5-lipoxygenase (5-LOX), which is involved in the metabolism of arachidonic acid to produce leukotrienes. Leukotrienes are inflammatory mediators that play a role in the pathogenesis of various diseases, including asthma, allergic reactions, and inflammatory bowel disease. 5-LOX-APs are expressed in various cells, including neutrophils, eosinophils, and macrophages, and are thought to play a role in regulating the production of leukotrienes in these cells. Inhibition of 5-LOX-APs has been proposed as a potential therapeutic strategy for the treatment of inflammatory diseases.
Arachidonic acid is a polyunsaturated omega-6 fatty acid that is found in the cell membranes of all living organisms. It is an essential fatty acid, meaning that it cannot be synthesized by the body and must be obtained through the diet. In the medical field, arachidonic acid plays a significant role in various physiological processes, including inflammation, immune function, and blood clotting. It is also a precursor to the production of eicosanoids, a group of biologically active compounds that have diverse effects on the body, including vasodilation, vasoconstriction, and pain perception. Arachidonic acid is commonly found in foods such as fish, nuts, and seeds, and is also available as a dietary supplement. However, excessive consumption of arachidonic acid has been linked to an increased risk of certain health conditions, such as heart disease and cancer. Therefore, it is important to consume arachidonic acid in moderation as part of a balanced diet.
Leukotriene B4 (LTB4) is a biologically active lipid mediator that plays a key role in the inflammatory response. It is produced by leukocytes, particularly neutrophils, in response to various stimuli such as bacterial or fungal infections, tissue damage, or allergic reactions. LTB4 acts as a chemoattractant, recruiting more leukocytes to the site of inflammation and promoting their activation and migration. It also stimulates the release of other pro-inflammatory mediators, such as prostaglandins and cytokines, from leukocytes and other cells. In the medical field, LTB4 is often measured in blood or other body fluids as a marker of inflammation. It is also a target for the development of anti-inflammatory drugs, such as leukotriene receptor antagonists, which block the effects of LTB4 and reduce inflammation.
Arachidonic acid (AA) is a polyunsaturated omega-6 fatty acid that is found in the cell membranes of all living organisms. It is an essential fatty acid, meaning that it cannot be synthesized by the body and must be obtained through the diet. In the medical field, arachidonic acid is known for its role in the production of eicosanoids, a group of signaling molecules that play important roles in various physiological processes, including inflammation, blood clotting, and immune function. Eicosanoids are synthesized from arachidonic acid by enzymes called cyclooxygenases (COXs) and lipoxygenases (LOXs). Arachidonic acid is also a precursor to the synthesis of prostaglandins, which are another group of eicosanoids that have a wide range of effects on the body, including regulating blood pressure, controlling inflammation, and modulating pain and fever. In addition to its role in eicosanoid production, arachidonic acid is also important for maintaining the fluidity and integrity of cell membranes, and for regulating the activity of various enzymes and signaling molecules. Abnormal levels of arachidonic acid or disruptions in its metabolism have been linked to a number of medical conditions, including cardiovascular disease, inflammatory disorders, and neurological disorders. As a result, arachidonic acid is an important area of research in the medical field, with efforts focused on developing new treatments and therapies for these conditions.
5,8,11,14-Eicosatetraynoic acid (ETYA) is a type of omega-6 fatty acid that is found in small amounts in some plant oils, such as evening primrose oil and black currant seed oil. It is a polyunsaturated fatty acid, meaning that it has multiple double bonds in its carbon chain. In the medical field, ETYA is being studied for its potential health benefits. Some research suggests that ETYA may have anti-inflammatory properties and may be beneficial for conditions such as arthritis and inflammatory bowel disease. It may also have potential as an anti-cancer agent and may help to protect against heart disease by improving blood lipid profiles. However, more research is needed to fully understand the potential health benefits of ETYA and to determine the appropriate dosage and potential side effects. It is important to speak with a healthcare provider before taking any supplements or making changes to your diet.
Leukotriene A4 (LTA4) is a chemical compound that is produced by leukocytes (white blood cells) in response to inflammation. It is a precursor to other leukotrienes, which are signaling molecules that play a role in regulating immune responses and inflammation. LTA4 is synthesized from arachidonic acid, a fatty acid that is released from cell membranes in response to injury or infection. The enzyme 5-lipoxygenase (5-LOX) catalyzes the conversion of arachidonic acid to LTA4. LTA4 has several effects on the body, including: 1. Contraction of smooth muscle cells in the airways, leading to bronchoconstriction and difficulty breathing. 2. Increased production of mucus in the airways, which can lead to coughing and difficulty breathing. 3. Increased blood vessel permeability, which can lead to swelling and inflammation. 4. Increased production of other leukotrienes, which can amplify the inflammatory response. LTA4 is involved in several inflammatory diseases, including asthma, allergic reactions, and inflammatory bowel disease. Inhibitors of 5-LOX, which block the production of LTA4, are used as medications to treat these conditions.
Linoleic acid is an unsaturated fatty acid that is essential for human health. It is a polyunsaturated fatty acid (PUFA) that is a member of the omega-6 fatty acid family. Linoleic acid is a liquid at room temperature and is found in many plant-based oils, such as soybean oil, sunflower oil, and corn oil. In the medical field, linoleic acid is considered an essential nutrient because the body cannot produce it on its own and must obtain it through the diet. It is important for maintaining healthy skin, hair, and nails, and for supporting the immune system. Linoleic acid is also important for brain function and may help to reduce the risk of certain diseases, such as heart disease and cancer. However, it is important to note that while linoleic acid is essential for health, it is also possible to consume too much of it. Consuming large amounts of linoleic acid can increase the risk of certain health problems, such as inflammation and oxidative stress. Therefore, it is important to consume linoleic acid in moderation as part of a balanced diet.
Eicosanoids are a group of biologically active molecules derived from the 20-carbon fatty acid, arachidonic acid. They are produced by various cells in the body, including immune cells, endothelial cells, and smooth muscle cells, in response to various stimuli such as injury, inflammation, or stress. Eicosanoids play a crucial role in many physiological processes, including inflammation, blood clotting, and blood pressure regulation. They are also involved in the regulation of pain, fever, and immune responses. There are several types of eicosanoids, including prostaglandins, thromboxanes, leukotrienes, and lipoxins. Each type of eicosanoid has a specific function and can have both pro-inflammatory and anti-inflammatory effects, depending on the context in which they are produced. In the medical field, eicosanoids are often targeted for therapeutic purposes, particularly in the treatment of inflammatory and cardiovascular diseases. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen work by inhibiting the production of prostaglandins, which are key mediators of inflammation. Similarly, drugs that target specific eicosanoid receptors can be used to treat conditions such as asthma, rheumatoid arthritis, and cardiovascular disease.
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Lipid peroxides are chemical compounds that are formed when lipids (fats and oils) are exposed to oxygen and undergo a process called oxidation. In the medical field, lipid peroxides are often measured as a biomarker of oxidative stress, which is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to neutralize them. Oxidative stress has been linked to a variety of health problems, including cardiovascular disease, cancer, and neurodegenerative disorders.
Linoleic acid is an unsaturated fatty acid that is essential for human health. It is a polyunsaturated fatty acid (PUFA) that is a member of the omega-6 fatty acid family. Linoleic acid is a liquid at room temperature and is found in many plant-based oils, such as soybean oil, sunflower oil, and corn oil. In the medical field, linoleic acid is considered an essential nutrient because the human body cannot produce it on its own and must obtain it through the diet. It is important for maintaining healthy skin, hair, and nails, and for supporting the immune system. Linoleic acid is also important for brain function and may help to reduce the risk of certain diseases, such as heart disease and cancer. However, it is important to note that while linoleic acid is essential for health, it is also possible to consume too much of it. Consuming excessive amounts of linoleic acid has been linked to an increased risk of certain health problems, such as inflammation and obesity. Therefore, it is important to consume linoleic acid in moderation as part of a balanced diet.
Flavanones are a type of flavonoid, which are naturally occurring compounds found in many fruits, vegetables, and plants. They are known for their antioxidant properties and have been studied for their potential health benefits. In the medical field, flavanones have been shown to have a number of potential health benefits, including: 1. Cardiovascular health: Flavanones have been shown to help lower blood pressure and improve blood flow, which can help reduce the risk of heart disease. 2. Anti-inflammatory effects: Flavanones have been shown to have anti-inflammatory properties, which may help reduce the risk of chronic diseases such as cancer, diabetes, and Alzheimer's disease. 3. Improved cognitive function: Some studies have suggested that flavanones may help improve cognitive function and memory. 4. Anti-cancer effects: Flavanones have been shown to have anti-cancer properties, and may help reduce the risk of certain types of cancer, including breast, prostate, and colon cancer. Flavanones are found in a variety of foods, including citrus fruits, onions, and apples. They are also available as dietary supplements. However, more research is needed to fully understand the potential health benefits of flavanones and to determine the optimal dosage and duration of use.
Lipoxins are a class of bioactive lipids that are produced by leukocytes (white blood cells) in response to inflammation. They are synthesized from arachidonic acid, which is an omega-6 fatty acid found in cell membranes. Lipoxins have anti-inflammatory properties and play a role in resolving inflammation. They can inhibit the production of pro-inflammatory cytokines and chemokines, reduce the recruitment of immune cells to the site of inflammation, and promote the clearance of apoptotic cells. Lipoxins have been implicated in a variety of inflammatory conditions, including asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, and cardiovascular disease. They have also been shown to have potential therapeutic applications in these conditions. Overall, lipoxins are an important class of molecules that play a critical role in regulating inflammation and promoting tissue repair.
Calcimycin, also known as FK506, is a medication that belongs to a class of drugs called immunosuppressants. It is primarily used to prevent organ rejection in people who have received a transplant, such as a kidney or liver transplant. Calcimycin works by inhibiting the activity of a protein called calcineurin, which plays a key role in the activation of T-cells, a type of white blood cell that is involved in the immune response. By inhibiting calcineurin, calcimycin helps to suppress the immune system and reduce the risk of organ rejection. Calcimycin is usually given as an oral tablet or as an injection. It can cause side effects such as headache, nausea, and diarrhea, and it may interact with other medications.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce inflammation, and lower fever. It works by blocking the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Indomethacin is available in various forms, including tablets, capsules, and suppositories. It is often prescribed for conditions such as arthritis, menstrual cramps, and headaches. It can also be used to treat gout, kidney stones, and other inflammatory conditions. However, indomethacin can have side effects, including stomach pain, nausea, vomiting, and diarrhea. It can also increase the risk of bleeding and ulcers in the stomach and intestines. Therefore, it is important to use indomethacin only as directed by a healthcare provider and to report any side effects immediately.
Leukotriene antagonists are a class of medications that block the action of leukotrienes, which are chemical messengers produced by the immune system. These drugs are used to treat a variety of conditions, including asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis (hay fever). Leukotrienes play a role in the inflammatory response and can cause constriction of the airways, leading to difficulty breathing. By blocking the action of leukotrienes, leukotriene antagonists can help to relax the airways and improve breathing in people with asthma or COPD. There are several different types of leukotriene antagonists available, including montelukast (Singulair) and zafirlukast (Accolate). These drugs are usually taken by mouth and are generally well-tolerated. However, like all medications, they can cause side effects, such as headache, nausea, and dizziness. It is important to talk to a healthcare provider about the potential benefits and risks of leukotriene antagonists before starting treatment.
Prostaglandin-endoperoxide synthases, also known as cyclooxygenases (COXs), are enzymes that play a crucial role in the production of prostaglandins and thromboxanes, which are hormone-like substances that regulate various physiological processes in the body. There are two main isoforms of COX: COX-1 and COX-2. COX-1 is constitutively expressed in most tissues and is involved in the maintenance of normal physiological functions, such as platelet aggregation, gastric mucosal protection, and renal blood flow regulation. In contrast, COX-2 is induced in response to various stimuli, such as inflammation, injury, and stress, and is primarily involved in the production of prostaglandins that mediate inflammatory and pain responses. Prostaglandins and thromboxanes are synthesized from arachidonic acid, a polyunsaturated fatty acid that is released from membrane phospholipids in response to various stimuli. COXs catalyze the conversion of arachidonic acid to prostaglandin H2 (PGH2), which is then further metabolized to various prostaglandins and thromboxanes by other enzymes. In the medical field, COX inhibitors are commonly used as anti-inflammatory and analgesic drugs. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen are examples of COX inhibitors that are widely used to treat pain, inflammation, and fever. However, long-term use of NSAIDs can have adverse effects on the gastrointestinal tract and cardiovascular system, which has led to the development of newer COX-2 selective inhibitors, such as celecoxib and rofecoxib, that are thought to have fewer gastrointestinal side effects.
Hydroxyurea is a medication that is used to treat certain types of blood disorders, including sickle cell anemia and myelofibrosis. It works by slowing down the production of new blood cells in the bone marrow, which can help to reduce the number of abnormal red blood cells in the body and prevent them from getting stuck in small blood vessels. Hydroxyurea is usually taken by mouth in the form of tablets or capsules, and the dosage and frequency of administration will depend on the specific condition being treated and the individual patient's response to the medication. It is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns to them right away.
Leukotriene C4 (LTC4) is a chemical compound that is produced by leukocytes (white blood cells) in response to inflammation. It is a member of a larger group of compounds called leukotrienes, which are involved in the inflammatory response and play a role in the development of asthma, allergic reactions, and other inflammatory conditions. LTC4 is produced by the enzyme 5-lipoxygenase, which converts arachidonic acid, a fatty acid found in cell membranes, into LTC4 and other leukotrienes. LTC4 is then released from the leukocyte and acts on nearby cells to cause inflammation and other effects. LTC4 acts on specific receptors on the surface of cells, triggering a cascade of events that leads to the release of other inflammatory mediators, such as histamine and prostaglandins. It also causes constriction of blood vessels and smooth muscles, which can contribute to inflammation and pain. In the medical field, LTC4 is often studied as a potential target for the treatment of inflammatory conditions, such as asthma and allergic reactions. Inhibitors of 5-lipoxygenase, which are drugs that prevent the production of LTC4 and other leukotrienes, are sometimes used to treat these conditions.
Phospholipases A are a group of enzymes that hydrolyze the sn-2 ester bond of phospholipids, releasing fatty acids and lysophospholipids. There are several types of phospholipases A, including phospholipase A1, phospholipase A2, and phospholipase A3, each with different substrate specificities and functions. In the medical field, phospholipases A play important roles in various physiological and pathological processes. For example, they are involved in the metabolism of cellular membranes, the regulation of inflammation, and the activation of signaling pathways. Phospholipases A are also involved in the pathogenesis of various diseases, including cardiovascular disease, cancer, and neurodegenerative disorders. Pharmacological agents that target phospholipases A have been developed for the treatment of various diseases, including cancer, inflammation, and cardiovascular disease. For example, some phospholipase A inhibitors have been shown to have anti-inflammatory and anti-cancer effects, while some phospholipase A activators have been shown to have beneficial effects in cardiovascular disease.
Receptors, Leukotriene are a type of protein found on the surface of cells in the immune system, specifically white blood cells called leukocytes. These receptors are responsible for binding to and responding to leukotrienes, which are chemical messengers produced by leukocytes in response to inflammation or injury. Activation of leukotriene receptors can cause a variety of physiological effects, including constriction of blood vessels, increased mucus production, and recruitment of more immune cells to the site of inflammation. Understanding the role of leukotriene receptors in the immune system is important for developing treatments for a variety of inflammatory and allergic conditions.
Phospholipases A2 (PLA2s) are a family of enzymes that hydrolyze the sn-2 ester bond of phospholipids, releasing fatty acids and lysophospholipids. There are several types of PLA2s, including secreted PLA2s (sPLA2s), cytosolic PLA2s (cPLA2s), and calcium-independent PLA2s (iPLA2s), each with distinct properties and functions. In the medical field, PLA2s have been implicated in various diseases and conditions, including inflammation, cancer, and neurodegenerative disorders. For example, sPLA2s are involved in the production of arachidonic acid, a precursor of pro-inflammatory eicosanoids, and have been shown to play a role in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and asthma. cPLA2s are involved in the regulation of cell signaling and have been implicated in the development of cancer. iPLA2s have been shown to play a role in the regulation of membrane fluidity and have been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease. Overall, PLA2s are important enzymes that play a role in various physiological and pathological processes, and their study has led to the development of potential therapeutic targets for a range of diseases.
Caffeic acids are a group of phenolic compounds that are naturally found in many plants, including coffee, tea, and fruits. They are known for their antioxidant and anti-inflammatory properties and have been studied for their potential health benefits. In the medical field, caffeic acids are used as ingredients in various pharmaceutical and cosmetic products. They have been shown to have potential therapeutic effects in the treatment of a variety of conditions, including cancer, diabetes, and cardiovascular disease. Caffeic acids are also used in traditional medicine to treat a range of ailments, including digestive problems, skin conditions, and respiratory infections. They are often used in combination with other natural compounds to enhance their therapeutic effects. Overall, caffeic acids are a promising area of research in the medical field, and their potential health benefits continue to be explored.
Catechols are a class of organic compounds that contain a catechol group, which is a hydroxybenzene group with two hydroxyl (-OH) groups attached to a benzene ring. Catechols are found naturally in many plants and animals, and they are also synthesized in the body as part of various metabolic processes. In the medical field, catechols are often used as antioxidants and anti-inflammatory agents. They have been shown to have a number of potential health benefits, including reducing the risk of heart disease, improving blood flow, and protecting against oxidative stress. Catechols are also used in the production of a variety of pharmaceuticals and medical devices, including drugs for treating high blood pressure, heart disease, and Parkinson's disease. They are also used in the manufacturing of dyes, pigments, and other industrial chemicals.
Linolenic acid is an omega-3 fatty acid that is essential for human health. It is a polyunsaturated fatty acid that is found in plant-based oils, such as flaxseed oil, soybean oil, and canola oil. Linolenic acid is important for maintaining healthy skin, hair, and nails, and it also plays a role in reducing inflammation in the body. In the medical field, linolenic acid is sometimes used to treat conditions such as eczema, psoriasis, and other skin disorders. It may also be used to reduce the risk of heart disease and stroke, as it can help to lower blood pressure and reduce inflammation in the arteries.
Leukotriene E4 (LTE4) is a type of leukotriene, which is a chemical substance produced by white blood cells (leukocytes) in response to inflammation. LTE4 is a potent mediator of inflammation and can cause constriction of blood vessels, increased mucus production, and recruitment of immune cells to the site of inflammation. It is involved in the pathophysiology of various inflammatory diseases, including asthma, allergic rhinitis, and chronic obstructive pulmonary disease (COPD). LTE4 is also a biomarker of inflammation and can be measured in blood or sputum samples to help diagnose and monitor these conditions.
Benzeneacetamides are a class of organic compounds that contain a benzene ring and an amide group. They are derivatives of benzene and acetamide, and are often used as intermediates in the synthesis of other compounds. In the medical field, benzeneacetamides have been studied for their potential use as anti-inflammatory agents, analgesics, and anticonvulsants. Some specific benzeneacetamides, such as acetaminophen (also known as paracetamol), are widely used as over-the-counter pain relievers and fever reducers. However, it is important to note that the use of benzeneacetamides can also have potential side effects and risks, and should only be used under the guidance of a healthcare professional.
In the medical field, "Fatty Acids, Unsaturated" refers to a type of fatty acid that contains one or more double bonds in the carbon chain. Unsaturated fatty acids are classified into two categories: monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs). MUFAs have one double bond in their carbon chain, while PUFAs have two or more double bonds. Unsaturated fatty acids are considered healthier than saturated fatty acids because they can lower cholesterol levels, reduce the risk of heart disease, and improve blood pressure. Some examples of unsaturated fatty acids include oleic acid (a MUFA found in olive oil), linoleic acid (a PUFA found in vegetable oils), and alpha-linolenic acid (an omega-3 PUFA found in fish oil). In medical contexts, the consumption of unsaturated fatty acids is often recommended as part of a healthy diet to promote cardiovascular health and reduce the risk of chronic diseases.
8,11,14-Eicosatrienoic acid (ETA) is a type of polyunsaturated fatty acid (PUFA) that belongs to the omega-6 family. It is a derivative of linoleic acid, which is an essential fatty acid that the body cannot produce on its own and must be obtained through the diet. In the medical field, ETA has been studied for its potential health benefits and therapeutic applications. Some research suggests that ETA may have anti-inflammatory and anti-cancer properties, and may be useful in the treatment of various conditions such as cardiovascular disease, asthma, and inflammatory bowel disease. However, more research is needed to fully understand the effects of ETA on human health and to determine its optimal dosage and potential side effects. As with any dietary supplement or medication, it is important to consult with a healthcare professional before using ETA or any other supplement.
Epoxide hydrolases are a group of enzymes that catalyze the hydrolysis of epoxides, which are three-membered cyclic ethers. These enzymes play an important role in the metabolism of various compounds, including some drugs and environmental pollutants. In the medical field, epoxide hydrolases are of particular interest because they can modulate the activity of certain drugs by converting them into less active or inactive metabolites. For example, some anti-cancer drugs, such as tamoxifen and etoposide, are activated by epoxide hydrolases in certain tissues, while others, such as benzo[a]pyrene, are detoxified by these enzymes. Epoxide hydrolases are also involved in the metabolism of some endogenous compounds, such as fatty acids and bile acids. In addition, they have been implicated in the development of certain diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Overall, epoxide hydrolases play a critical role in the metabolism of a wide range of compounds, and their activity can have important implications for human health.
Pyrazoles are a class of heterocyclic compounds that contain a five-membered ring with one nitrogen atom and two carbon atoms. They are commonly used in the medical field as pharmaceuticals and as active ingredients in various drugs. Pyrazoles have a wide range of biological activities, including anti-inflammatory, antifungal, antiviral, and antihypertensive properties. Some examples of drugs that contain pyrazoles include: 1. Metformin: A medication used to treat type 2 diabetes. 2. Etoricoxib: A nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. 3. Ritonavir: An antiretroviral drug used to treat HIV/AIDS. 4. Alendronate: A medication used to treat osteoporosis. 5. Cilostazol: A medication used to treat peripheral arterial disease. Pyrazoles are also used as research tools in the field of medicinal chemistry to develop new drugs with specific biological activities.
Receptors, Leukotriene B4 (LTB4) are a type of protein receptor found on the surface of certain cells in the immune system, such as neutrophils and macrophages. These receptors are activated by the binding of the signaling molecule leukotriene B4 (LTB4), which is produced by immune cells in response to inflammation or infection. When LTB4 binds to its receptor, it triggers a cascade of intracellular signaling events that can lead to a variety of cellular responses, including the activation and recruitment of immune cells to the site of inflammation, the production of pro-inflammatory cytokines and chemokines, and the promotion of tissue damage. In the medical field, the study of LTB4 receptors and their role in inflammation and immune responses is important for understanding the pathophysiology of a variety of diseases, including asthma, chronic obstructive pulmonary disease (COPD), and certain types of cancer. In addition, drugs that target LTB4 receptors are being developed as potential treatments for these conditions.
Thromboxane B2 is a potent vasoconstrictor and platelet aggregator that is produced by platelets and other cells in response to injury or inflammation. It plays a key role in the formation of blood clots and is involved in various cardiovascular diseases, such as atherosclerosis, myocardial infarction, and stroke. Thromboxane B2 is also a potent stimulator of uterine contractions during pregnancy and can contribute to the development of preterm labor.
Oxylipins are a class of bioactive lipids that are derived from polyunsaturated fatty acids through the action of enzymes called lipoxygenases, cyclooxygenases, and cytochrome P450 monooxygenases. These enzymes catalyze the oxidation of fatty acids, leading to the formation of various oxylipins, including hydroxy fatty acids, epoxy fatty acids, and dihydroxy fatty acids. Oxylipins play important roles in various physiological processes, including inflammation, immune response, blood pressure regulation, and cell signaling. They are also involved in the development and progression of various diseases, including cardiovascular disease, cancer, and neurodegenerative disorders. In the medical field, oxylipins are often studied as potential biomarkers or therapeutic targets for these diseases. For example, some oxylipins have been shown to have anti-inflammatory and anti-cancer properties, while others have been implicated in the development of cardiovascular disease. Therefore, understanding the metabolism and function of oxylipins is important for developing new treatments and improving patient outcomes.
Lipoxygenases are a family of enzymes that catalyze the oxidation of polyunsaturated fatty acids, particularly arachidonic acid, to produce a variety of bioactive compounds known as eicosanoids. These compounds play important roles in various physiological processes, including inflammation, blood pressure regulation, and immune responses. There are several types of lipoxygenases, including 5-lipoxygenase (5-LOX), 12-lipoxygenase (12-LOX), and 15-lipoxygenase (15-LOX), each of which produces a different set of eicosanoids. For example, 5-LOX produces leukotrienes, which are involved in the inflammatory response, while 12-LOX and 15-LOX produce hydroxyeicosatetraenoic acids (HETEs), which can have both pro-inflammatory and anti-inflammatory effects. Lipoxygenases are found in a variety of tissues, including the lung, liver, and immune cells, and their activity is regulated by a number of factors, including the availability of polyunsaturated fatty acids and the presence of specific inhibitors or activators. In some cases, dysregulation of lipoxygenase activity has been linked to various diseases, including asthma, cardiovascular disease, and cancer.
Quinolines are a class of organic compounds that have a fused ring system consisting of a six-membered aromatic ring and a five-membered heterocyclic ring containing nitrogen. They are structurally related to quinine, which is a well-known antimalarial drug. In the medical field, quinolines have been studied for their potential therapeutic applications in various diseases. Some of the most notable examples include: 1. Antimalarial activity: Quinolines have been used as antimalarial drugs for many years, with quinine being the most widely used. However, resistance to quinine has emerged in some regions, leading to the development of new quinoline-based drugs, such as chloroquine and artemisinin. 2. Antibacterial activity: Some quinolines have been found to have antibacterial activity against a range of gram-positive and gram-negative bacteria. For example, nalidixic acid is a quinoline antibiotic used to treat urinary tract infections caused by certain bacteria. 3. Antiviral activity: Quinolines have also been studied for their potential antiviral activity against viruses such as influenza, HIV, and herpes simplex virus. 4. Antifungal activity: Some quinolines have been found to have antifungal activity against Candida species, which are common causes of fungal infections in humans. Overall, quinolines have a diverse range of potential therapeutic applications in the medical field, and ongoing research is exploring their use in the treatment of various diseases.
Quinacrine is an antimalarial drug that was first synthesized in the early 20th century. It is a synthetic antimalarial agent that is effective against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum, the parasite that causes the most severe form of malaria. Quinacrine is a yellow-orange crystalline powder that is insoluble in water but soluble in organic solvents. It is usually administered orally as a tablet or as a suspension in water. Quinacrine works by inhibiting the growth and reproduction of the Plasmodium parasite in the red blood cells of the host. It does this by interfering with the parasite's ability to synthesize heme, a vital component of hemoglobin, which is necessary for the survival of the parasite. Quinacrine has also been used to treat other parasitic infections, such as leishmaniasis and schistosomiasis. However, its use has been limited due to its side effects, which include nausea, vomiting, diarrhea, and skin rashes. Additionally, quinacrine has been associated with an increased risk of liver damage and has been banned in some countries due to its potential carcinogenic effects.
Dinoprostone is a synthetic prostaglandin E1 (PGE1) medication that is used in the medical field to induce labor in pregnant women who are past their due date or who are at risk of complications during delivery. It is typically administered vaginally as a gel or tablet, and works by stimulating the muscles of the uterus to contract and push the baby out of the womb. Dinoprostone is also sometimes used to treat certain conditions that can cause bleeding in the uterus, such as uterine fibroids or abnormal bleeding during pregnancy. It is generally considered safe and effective for use in pregnant women, but like all medications, it can cause side effects in some people. These may include cramping, bleeding, and uterine contractions.
In the medical field, peroxides are chemical compounds that contain the oxygen-oxygen (O-O) bond. They are commonly used as disinfectants, bleaching agents, and oxidizing agents in various medical applications. One of the most well-known peroxides in medicine is hydrogen peroxide (H2O2), which is used as a topical antiseptic to clean wounds and prevent infection. Hydrogen peroxide is also used as a mouthwash to treat gum disease and other oral infections. Other peroxides used in medicine include peroxyacetic acid (PAA), which is used as a disinfectant for medical equipment and surfaces, and peroxynitrite (ONOO-), which is a potent oxidizing agent that plays a role in the body's immune response. Peroxides can also be used in the treatment of certain medical conditions, such as the use of ozone therapy to treat chronic pain and other inflammatory conditions. However, the use of peroxides in medicine should be carefully monitored and controlled to avoid potential side effects and complications.
Benzoquinones are a class of organic compounds that contain a benzene ring with two ketone groups (-C=O) attached to adjacent carbon atoms. They are commonly found in nature and are also synthesized in the laboratory for various industrial and medicinal applications. In the medical field, benzoquinones have been studied for their potential therapeutic effects. Some benzoquinones have been found to have anti-inflammatory, anti-cancer, and anti-bacterial properties. For example, some benzoquinones have been shown to inhibit the growth of certain types of cancer cells, while others have been found to have anti-inflammatory effects in animal models of inflammatory diseases. However, it is important to note that not all benzoquinones are safe or effective for medical use, and some may even be toxic or harmful. Therefore, the use of benzoquinones in medicine should be carefully evaluated and monitored by medical professionals.
Cyclooxygenase 2 (COX-2) is an enzyme that is involved in the production of prostaglandins, which are hormone-like substances that play a role in various physiological processes in the body, including inflammation, pain, and fever. COX-2 is primarily found in cells of the immune system and in the lining of the gastrointestinal tract. In the medical field, COX-2 inhibitors are a class of drugs that are used to reduce inflammation and relieve pain. They are often prescribed for conditions such as arthritis, menstrual cramps, and headaches. However, long-term use of COX-2 inhibitors has been associated with an increased risk of cardiovascular events, such as heart attacks and strokes, which has led to some restrictions on their use.
In the medical field, RNA, Messenger (mRNA) refers to a type of RNA molecule that carries genetic information from DNA in the nucleus of a cell to the ribosomes, where proteins are synthesized. During the process of transcription, the DNA sequence of a gene is copied into a complementary RNA sequence called messenger RNA (mRNA). This mRNA molecule then leaves the nucleus and travels to the cytoplasm of the cell, where it binds to ribosomes and serves as a template for the synthesis of a specific protein. The sequence of nucleotides in the mRNA molecule determines the sequence of amino acids in the protein that is synthesized. Therefore, changes in the sequence of nucleotides in the mRNA molecule can result in changes in the amino acid sequence of the protein, which can affect the function of the protein and potentially lead to disease. mRNA molecules are often used in medical research and therapy as a way to introduce new genetic information into cells. For example, mRNA vaccines work by introducing a small piece of mRNA that encodes for a specific protein, which triggers an immune response in the body.
Indoles are a class of organic compounds that contain a six-membered aromatic ring with a nitrogen atom at one of the corners of the ring. They are commonly found in a variety of natural products, including some plants, bacteria, and fungi. In the medical field, indoles have been studied for their potential therapeutic effects, particularly in the treatment of cancer. Some indoles have been shown to have anti-inflammatory, anti-cancer, and anti-bacterial properties, and are being investigated as potential drugs for the treatment of various diseases.
Leukotriene D4 (LTD4) is a chemical compound that belongs to a group of molecules called leukotrienes. Leukotrienes are produced by immune cells called leukocytes and are involved in the inflammatory response. LTD4 is a potent bronchoconstrictor, meaning that it can cause the airways to narrow and become more difficult to breathe. This effect makes LTD4 a key mediator in the development of asthma and other inflammatory airway diseases. In addition to its bronchoconstrictor effects, LTD4 can also cause smooth muscle contraction, increase mucus production, and recruit immune cells to the site of inflammation. As a result, LTD4 plays a central role in the pathophysiology of many inflammatory conditions, including asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis.
Receptors, Eicosanoid are a type of protein molecules that are found on the surface of cells in the body. They are responsible for binding to and responding to signaling molecules called eicosanoids, which are derived from the metabolism of fatty acids. Eicosanoids play a variety of roles in the body, including regulating inflammation, blood pressure, and blood clotting. Receptors, Eicosanoid are involved in the signaling pathways that mediate the effects of eicosanoids, and they are important for maintaining normal physiological function. In the medical field, understanding the function and regulation of Receptors, Eicosanoid is important for developing treatments for a variety of diseases and conditions that are associated with abnormal eicosanoid signaling.
Platelet Activating Factor (PAF) is a signaling molecule that plays a role in the immune response and inflammation. It is produced by various cells, including platelets, leukocytes, and endothelial cells, and acts on a specific receptor on the surface of these cells to trigger a variety of cellular responses. PAF is involved in the recruitment and activation of immune cells, such as neutrophils and monocytes, to sites of inflammation. It also promotes the release of other inflammatory mediators, such as prostaglandins and leukotrienes, and can cause vasodilation and increased permeability of blood vessels, leading to edema and tissue damage. In addition to its role in inflammation, PAF has been implicated in a variety of other conditions, including allergic reactions, asthma, and certain types of heart disease. It is also a potential therapeutic target for the treatment of these conditions.
Cyclopentanes are a type of organic compound that contain a five-membered ring of carbon atoms with one hydrogen atom attached to each carbon atom. They are commonly used as solvents, intermediates in chemical reactions, and as starting materials for the synthesis of other compounds. In the medical field, cyclopentanes are not typically used as drugs or therapeutic agents. However, some cyclopentane derivatives have been studied for their potential use in the treatment of various diseases, including cancer and viral infections.
Intramolecular oxidoreductases are a class of enzymes that catalyze redox reactions within a single molecule. These enzymes are involved in various biological processes, including metabolism, signal transduction, and gene expression. They typically contain a redox-active site that undergoes changes in oxidation state during the catalytic cycle, allowing them to transfer electrons between different parts of the molecule. Examples of intramolecular oxidoreductases include thioredoxins, glutaredoxins, and peroxiredoxins. These enzymes play important roles in maintaining cellular redox homeostasis and protecting cells against oxidative stress.
Prostaglandins are a group of hormone-like substances that are produced in the body from fatty acids. They play a variety of roles in the body, including regulating inflammation, blood pressure, and pain. Prostaglandins are synthesized in cells throughout the body, including in the lining of the stomach, the lungs, and the reproductive organs. They are also produced in response to injury or infection, and are thought to play a role in the body's healing process. Prostaglandins are often used as medications to reduce inflammation and pain, and are also used to prevent blood clots and to induce labor in pregnant women.
Nonheme iron proteins are a class of proteins that contain iron but do not have the heme prosthetic group. Heme is a complex organic molecule that contains an iron atom coordinated to a porphyrin ring, and it is found in many proteins involved in oxygen transport, such as hemoglobin and myoglobin. Nonheme iron proteins, on the other hand, contain iron that is not coordinated to a porphyrin ring and is instead bound to other ligands, such as histidine or cysteine residues. Nonheme iron proteins play a variety of roles in biological systems. For example, they are involved in the metabolism of iron, the detoxification of reactive oxygen species, and the catalysis of various chemical reactions. Some examples of nonheme iron proteins include ferritin, transferrin, and cytochrome P450 enzymes.
In the medical field, "Pyrans" refers to a type of cyclic compound that contains a six-membered ring with five carbon atoms and one oxygen atom. Pyrans are a subclass of the larger group of heterocyclic compounds, which are molecules that contain at least one atom other than carbon in their ring structure. Pyrans are commonly found in nature and are often used as building blocks for the synthesis of various natural products, such as sugars, flavonoids, and alkaloids. In medicine, pyrans are used as active ingredients in various drugs and therapeutic agents, including antibiotics, anti-inflammatory drugs, and antiviral agents. One well-known example of a pyran is glucose, which is a simple sugar that is essential for energy metabolism in living organisms. Other examples of pyrans include fructose, ribose, and xanthan gum, which are used in food and pharmaceutical industries.
Umbelliferones are a group of natural compounds that are found in plants, particularly in the Apiaceae family. They are also known as coumarins and are characterized by their characteristic sweet, fruity odor. Umbelliferones have a wide range of biological activities, including anti-inflammatory, anticoagulant, and antioxidant properties. They have been studied for their potential use in the treatment of various medical conditions, such as cancer, diabetes, and cardiovascular disease. In the medical field, umbelliferones are often used as natural remedies or as ingredients in dietary supplements.
In the medical field, isoenzymes refer to different forms of enzymes that have the same chemical structure and catalytic activity, but differ in their amino acid sequence. These differences can arise due to genetic variations or post-translational modifications, such as phosphorylation or glycosylation. Isoenzymes are often used in medical diagnosis and treatment because they can provide information about the function and health of specific organs or tissues. For example, the presence of certain isoenzymes in the blood can indicate liver or kidney disease, while changes in the levels of specific isoenzymes in the brain can be indicative of neurological disorders. In addition, isoenzymes can be used as biomarkers for certain diseases or conditions, and can be targeted for therapeutic intervention. For example, drugs that inhibit specific isoenzymes can be used to treat certain types of cancer or heart disease.
Zymosan is a polysaccharide derived from the cell walls of yeasts and other fungi. It is commonly used in medical research as an activator of the immune system, particularly in the study of inflammation and autoimmune diseases. When zymosan is injected into the body, it triggers an immune response that involves the release of various inflammatory mediators, such as cytokines and chemokines. This response can be used to study the function of immune cells and the signaling pathways involved in inflammation. Zymosan has also been used in clinical trials as a potential treatment for various conditions, including rheumatoid arthritis, psoriasis, and sepsis. However, more research is needed to fully understand its therapeutic potential and potential side effects.
Dioctyl sulfosuccinic acid (DOSSA) is a chemical compound that is used in various medical applications. It is a white, odorless, and water-soluble solid that is commonly used as a surfactant, emulsifier, and solubilizer in pharmaceuticals, cosmetics, and personal care products. In the medical field, DOSSA is used as a solubilizing agent to improve the solubility of poorly water-soluble drugs, which can enhance their bioavailability and efficacy. It is also used as a stabilizing agent to prevent the aggregation of proteins and other biomolecules, which can improve their stability and shelf-life. DOSSA is also used as a preservative in some medical products, such as eye drops and ointments, to prevent the growth of microorganisms and extend their shelf-life. It is important to note that while DOSSA is generally considered safe for use in medical products, it can cause skin irritation and allergic reactions in some individuals. Therefore, it is important to use caution when handling and administering products containing DOSSA, and to follow proper safety protocols to minimize the risk of adverse reactions.
Prostaglandins E (PGE) are a group of lipid signaling molecules that are produced in the body from arachidonic acid. They are synthesized by enzymes called cyclooxygenases (COX) and are involved in a wide range of physiological processes, including inflammation, pain, fever, and blood clotting. PGEs are produced in response to various stimuli, such as injury, infection, or stress, and act as messengers to regulate cellular responses. They can also act as vasodilators, increasing blood flow to tissues, and as bronchodilators, relaxing smooth muscle in the airways. In the medical field, PGEs are used as drugs to treat a variety of conditions, including pain, inflammation, and asthma. They are also used in research to study the mechanisms of these processes and to develop new treatments.
Pleurisy is a medical condition characterized by inflammation of the pleura, which is the thin layer of tissue that covers the lungs and lines the inside of the chest cavity. This inflammation can cause the pleura to become thickened, sticky, and inflamed, leading to pain and difficulty breathing. There are two types of pleurisy: viral and bacterial. Viral pleurisy is usually caused by a respiratory virus, such as the flu or COVID-19, and is usually self-limiting. Bacterial pleurisy, on the other hand, is caused by bacteria and requires antibiotics to treat. Symptoms of pleurisy may include chest pain that worsens with deep breathing or coughing, difficulty breathing, fever, and a dry cough. Treatment for pleurisy typically involves pain management, antibiotics if the cause is bacterial, and rest. In severe cases, hospitalization may be necessary.
Pyrazolones are a class of organic compounds that contain a pyrazole ring with one or more hydroxyl groups attached to it. They are commonly used in the medical field as anti-inflammatory and analgesic drugs. One of the most well-known pyrazolones is phenylbutazone, which was introduced in the 1950s and was widely used as an anti-inflammatory drug for the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory conditions. However, phenylbutazone was later found to have serious side effects, including liver damage and aplastic anemia, and its use has been largely discontinued. Other pyrazolones that are still used in medicine include (etoricoxib), which is used to treat arthritis and other inflammatory conditions, and (), which is used to treat allergies and other respiratory conditions.
Membrane proteins are proteins that are embedded within the lipid bilayer of a cell membrane. They play a crucial role in regulating the movement of substances across the membrane, as well as in cell signaling and communication. There are several types of membrane proteins, including integral membrane proteins, which span the entire membrane, and peripheral membrane proteins, which are only in contact with one or both sides of the membrane. Membrane proteins can be classified based on their function, such as transporters, receptors, channels, and enzymes. They are important for many physiological processes, including nutrient uptake, waste elimination, and cell growth and division.
Calcium is a chemical element with the symbol Ca and atomic number 20. It is a vital mineral for the human body and is essential for many bodily functions, including bone health, muscle function, nerve transmission, and blood clotting. In the medical field, calcium is often used to diagnose and treat conditions related to calcium deficiency or excess. For example, low levels of calcium in the blood (hypocalcemia) can cause muscle cramps, numbness, and tingling, while high levels (hypercalcemia) can lead to kidney stones, bone loss, and other complications. Calcium supplements are often prescribed to people who are at risk of developing calcium deficiency, such as older adults, vegetarians, and people with certain medical conditions. However, it is important to note that excessive calcium intake can also be harmful, and it is important to follow recommended dosages and consult with a healthcare provider before taking any supplements.
Cyclooxygenase 1 (COX-1) is an enzyme that plays a crucial role in the production of prostaglandins, which are hormone-like substances that regulate various physiological processes in the body, including inflammation, pain, and blood clotting. COX-1 is found in most tissues throughout the body, including the stomach, blood vessels, and kidneys. In the medical field, COX-1 is often targeted for the treatment of various conditions, including pain, inflammation, and gastrointestinal disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen are commonly used to inhibit COX-1 activity, which can help reduce pain and inflammation. However, long-term use of high doses of NSAIDs can also lead to side effects such as stomach ulcers and increased risk of cardiovascular events. COX-1 is also involved in the production of thromboxanes, which are potent vasoconstrictors that can contribute to the formation of blood clots. As a result, COX-1 inhibitors have been developed for the treatment of conditions such as hypertension and cardiovascular disease. However, these drugs can also increase the risk of bleeding, particularly in patients taking anticoagulant medications.
Cycloheptanes are a group of organic compounds that consist of a seven-membered ring of carbon atoms. They are typically colorless, volatile liquids with a sweet odor. In the medical field, cycloheptanes are not commonly used as drugs or medications. However, they can be used as intermediates in the synthesis of other compounds, such as pharmaceuticals. Some cycloheptanes have been studied for their potential use as insecticides or as solvents for organic compounds.
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that is found in fish oil and other sources. It is a polyunsaturated fatty acid, which means that it has multiple double bonds in its carbon chain. EPA is a type of long-chain fatty acid that is essential for human health, meaning that it cannot be synthesized by the body and must be obtained through the diet. In the medical field, EPA is often used as a dietary supplement to help reduce inflammation and lower triglyceride levels in the blood. It has also been studied for its potential benefits in treating a variety of conditions, including cardiovascular disease, depression, and certain types of cancer. Some research suggests that EPA may have anti-inflammatory and anti-thrombotic effects, which may help to reduce the risk of heart disease. However, more research is needed to confirm these potential benefits and to determine the optimal dosage and duration of treatment.
Lipoxygenase
Linoleate 8R-lipoxygenase
Linoleate 9S-lipoxygenase
Linoleate 11-lipoxygenase
Linoleate 10R-lipoxygenase
Linolenate 9R-lipoxygenase
Arachidonate 5-lipoxygenase
Arachidonate 8-lipoxygenase
5-lipoxygenase-activating protein
Arachidonate 5-lipoxygenase inhibitor
Peripheral membrane protein
5-Hydroxyeicosatetraenoic acid
Flavocoxid
Masoprocol
AM-679 (FLAP inhibitor)
Resolvin
Zileuton
Ardisiaquinone
Fadogia homblei
Oxidative stress
Lipoxin
ALOXE3
15-Hydroxyeicosatetraenoic acid
LOXHD1
9-Hydroxyoctadecadienoic acid
Eicosanoid
Maresin
12-Hydroxyeicosatetraenoic acid
ALOX12
Centaureidin
ALOX12B gene: MedlinePlus Genetics
Lipoxygenase in plant cells - structure and function | Kwartalnik PBK
Rat 15-LO (Arachidonate 15-Lipoxygenase) ELISA Kit - Advanced BioChemicals
Mouse Arachidonate 15-lipoxygenase B (ALOX15B) ELISA Kit - Doron Scientific
Exercise-Induced Asthma: Practice Essentials, Background, Anatomy
Consensus design for improved thermostability of lipoxygenase from Anabaena sp. PCC 7120 | BMC Biotechnology | Full Text
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production...
Hsp90α recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells - Fingerprint - Taipei Medical...
A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with...
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Wheat Flour by William A. Atwell
Biologia
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Arachidonate3
- This enzyme is part of a family of enzymes called arachidonate lipoxygenases. (medlineplus.gov)
- Arachidonate lipoxygenases add oxygen molecules at different locations on the arachidonic acid molecule, producing a variety of substances called fatty acid hydroperoxides. (medlineplus.gov)
- It acts by targeting arachidonate 15-lipoxygenase. (pharmaceutical-technology.com)
Inhibitors1
- Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES. (bvsalud.org)
Inhibitor1
- A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. (ox.ac.uk)
Enzymes1
- Lipoxygenase enzymes are widely distributed in both the plants and animals. (pbkom.eu)
Inhibit2
- inhibition of 5-lipoxygenase (5-LO), which is expected to be involved in DHEA- and NALA-degradation pathway, also partially blocked the ability of DHEA and NALA to inhibit cell proliferation and phosphorylated Akt. (biomedcentral.com)
- Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. (bvsalud.org)
Enzyme1
- Also described are properties of biochemical and molecular reactions, including lipoxygenases which overlap with the enzyme in plant cells. (pbkom.eu)
Cyclooxygenase2
- The current experiments were designed to determine whether cyclooxygenase- and lipoxygenase-derived mediators contribute to the phosgene induced lung injury. (cdc.gov)
- Phosgene markedly increased lung weight gain, did not appear to increase the synthesis of cyclooxygenase metabolites, but increased 10-fold the synthesis of lipoxygenase products. (cdc.gov)
Specific1
- The presence of one lipoxygenase-active electrophoretic band was detected by a lipoxygenase- specific staining procedure. (cerealsgrains.org)
Products1
- These results suggest that lipoxygenase products contribute to the phosgene -induced lung damage. (cdc.gov)
Role2
- In addition to discussing the physiological role of lipoxygenase in plants, plant lipoxygenases described role in food technology and industry. (pbkom.eu)
- Krieg P, Furstenberger G. The role of lipoxygenases in epidermis. (medlineplus.gov)
Patients1
- Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis. (medlineplus.gov)
Function1
- The article discusses the structure and function of plant lipoxygenases. (pbkom.eu)
Arachidonic7
- 5-Lipoxygenase is the key enzyme in the synthesis of leukotriens (LT), bioactive metabolits of the arachidonic acid (AA). (uni-frankfurt.de)
- Arachidonate 5-lipoxygenase (5-LOX) is a member of the lipoxygenase family of enzymes that plays a key role in arachidonic acid metabolism. (nih.gov)
- Leukotrienes, generated from arachidonic acid through the action of 5-lipoxygenase (5-LO), have been known for over two decades and are implicated in a variety of inflammatory disorders. (medscape.com)
- Arachidonate lipoxygenases add oxygen molecules at different locations on the arachidonic acid molecule, producing a variety of substances called fatty acid hydroperoxides. (medlineplus.gov)
- Leukotrienes (LTs) are lipid mediators derived from the oxidation of arachidonic acid by 5-lipoxygenase (5-LO), and are classically involved in inflammation , allergies , and asthma . (bvsalud.org)
- Indomethacin inhibits arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in hamster isolated lungs. (nih.gov)
- Bengt Samuelsson found that prostaglandins are biologically synthesised from essential fatty acids via the intermediate: arachidonic acid, which takes either the cyclooxygenase (COX) pathway or the lipoxygenase pathway. (soci.org)
Arachidonate lipoxygenases1
- This enzyme is part of a family of enzymes called arachidonate lipoxygenases. (medlineplus.gov)
Cyclooxygenase3
- Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. (uchicago.edu)
- Extracts also modulated cytochrome P450 side- chain cleavage enzyme, 11-hydroxylase, cyclooxygenase-2, urokinase, and 5-lipoxygenase activity. (nih.gov)
- BW755C, a dual lipoxygenase/cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs. (aspetjournals.org)
Proteins1
- Compounds that bind to and inhibit the action of 5-LIPOXYGENASE-ACTIVATING PROTEINS. (jefferson.edu)
Platelet1
- Fatty acids are regulated in part by 12-lipoxygenase (12-LOX) and our recent work has suggested inhibiting 12-LOX may be one approach to limiting platelet activity. (nih.gov)
Zileuton2
Volatiles4
- 1 Green Leaf Volatiles (GLVs) synthesized through the lipoxygenase (LOX) enzymatic pathway are involved in plant aromatic reactions. (ac.be)
- Samples of unblanched (fresh), stannous chloride-treated, or blanched jalapeño peppers were measured for real-time generation of lipoxygenase-derived volatiles during 10 min after tissue disruption. (unboundmedicine.com)
- Frozen storage resulted in no major changes in the lipoxygenase-derived volatiles of whole and pureed blanched peppers after 9 mo. (unboundmedicine.com)
- AU - Azcarate,Carolina, AU - Barringer,Sheryl A, Y1 - 2010/10/07/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2011/9/13/medline SP - C710 EP - 21 JF - Journal of food science JO - J Food Sci VL - 75 IS - 9 N2 - Samples of unblanched (fresh), stannous chloride-treated, or blanched jalapeño peppers were measured for real-time generation of lipoxygenase-derived volatiles during 10 min after tissue disruption. (unboundmedicine.com)
Metabolites1
- The metabolites were analysed from the nonrecirculating perfusion effluent, which was extracted with ethyl acetate first at pH 7.4 (to extract unmetabolized AA, metabolites of lipoxygenase and HHT) and then at pH 3.5 for prostaglandins and thromboxanes. (nih.gov)
Soybean2
- Peptides derived from the longest loop region (L159-M325) of PEDF-R were screened for the effect on soybean lipoxygenase-V (LOX-V) in vitro. (nih.gov)
- The objective of this study was tof evaluate physical, chemical and sensorial differences between the two soy cultivar, with and without lipoxygenases (cultivars BRS 232 and BRS 257, of Embrapa, respectively) and to analyze the possible changes promoted by different radiation doses (0, 4 and 8 kGy) in raw and cooked soybean grains. (usp.br)
Pathway2
- Lipoxygenase enzymatic pathway is a widely studied mechanism in the plant kingdom. (ac.be)
- The 5-Lipoxygenase pathway results in the formation of leukotrienes, including leukotriene B(4) (LTB(4)), 5-oxo-6E,8Z,11Z,14Z-eicosatetranoic acid and the cysteinyl leukotrienes (LTC(4), LTD(4) and LTE(4)) and activates all four leukotriene receptors, BLT1, BLT2, cysLT(1) and cysLT(2). (nih.gov)
Polarization1
- Multi-walled carbon nanotube s stimulate arachidonate 5-lipoxygenase-dependent M1 polarization of macrophages to promote proinflammatory response in vitro. (cdc.gov)
Leukotriene1
- Das Enzym 5-Lipoxygenase (5-LO) spielt eine essentielle Rolle in der Biosynthese der Leukotriene, bioaktiver Metabolite der Arachidonsäure (AA), die an einer Vielzahl entzündlicher und allergischer Erkrankungen beteiligt sind. (uni-frankfurt.de)
Role1
- Krieg P, Furstenberger G. The role of lipoxygenases in epidermis. (medlineplus.gov)
Type1
- Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis. (medlineplus.gov)
Major1
- This graph shows the total number of publications written about "Arachidonate 5-Lipoxygenase" by people in this website by year, and whether "Arachidonate 5-Lipoxygenase" was a major or minor topic of these publications. (uchicago.edu)