Liposarcoma. Medical search

A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)

A liposarcoma containing myxomatous tissue. (Dorland, 27th ed)

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

Retroperitoneal neoplasms are a diverse group of tumors that originate in the retroperitoneal space, which is the area behind the peritoneum and includes the kidneys, adrenal glands, pancreas, and major blood vessels.

Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.

A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.

Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

A CCAAT-enhancer binding protein that is induced by DNA DAMAGE and growth arrest. It serves as a dominant negative inhibitor of other CCAAT-enhancer binding proteins.

Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.

Either of a pair of tubular structures formed by DUCTUS DEFERENS; ARTERIES; VEINS; LYMPHATIC VESSELS; and nerves. The spermatic cord extends from the deep inguinal ring through the INGUINAL CANAL to the TESTIS in the SCROTUM.

Tumor or cancer of the MALE GENITALIA.

A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.

The fold of peritoneum by which the COLON is attached to the posterior ABDOMINAL WALL.

Dioxoles are organic compounds containing a five-membered ring consisting of two oxygen atoms and two carbon atoms, often found as substructures in various natural and synthetic molecules, including certain pharmaceuticals and toxic dioxin pollutants.

A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.

Tumors or cancer of the MEDIASTINUM.

A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.

A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)

An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF.

The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.

A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)

A new rapid technique for the fixation of thyroid gland surgical specimens. (1/347)

One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule's capsule is recommended in order to identify capsular invasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of "Lymph Node Revealing Solution" (LNRS) for the rapid fixation (2h) of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis. (+info)

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. (2/347)

Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro. Because the differentiation status of liposarcoma is predictive of clinical outcomes, modulation of the differentiation status of a tumor may favorably impact clinical behavior. We have conducted a clinical trial for treatment of patients with advanced liposarcoma by using the peroxisome proliferator-activated receptor-gamma ligand troglitazone, in which extensive correlative laboratory studies of tumor differentiation were performed. We report here the results of three patients with intermediate to high-grade liposarcomas in whom troglitazone administration induced histologic and biochemical differentiation in vivo. Biopsies of tumors from each of these patients while on troglitazone demonstrated histologic evidence of extensive lipid accumulation by tumor cells and substantial increases in NMR-detectable tumor triglycerides compared with pretreatment biopsies. In addition, expression of several mRNA transcripts characteristic of differentiation in the adipocyte lineage was induced. There was also a marked reduction in immunohistochemical expression of Ki-67, a marker of cell proliferation. Together, these data indicate that terminal adipocytic differentiation was induced in these malignant tumors by troglitazone. These results indicate that lineage-appropriate differentiation can be induced pharmacologically in a human solid tumor. (+info)

Liposarcoma in association with total hip replacement. (3/347)

A possible relation between joint replacement and malignancy has previously been suggested in a few cases. In the majority of these cases, the authors found either malignant fibrous histiocytomas or osteosarcomas. We hereby report the first case of a liposarcoma in the vicinity of a joint prosthesis. (+info)

Prognostic relevance of p53 alterations and Mib-1 proliferation index in subgroups of primary liposarcomas. (4/347)

For prognostic analyses of p53 alterations (p53 gene mutations + p53 immunopositivity) and Mib-1 proliferation index, we investigated 42 primary malignant lipomatous tumors for which complete clinical data and a long follow-up were available. p53 gene mutations were investigated by PCR-single strand conformation polymorphism-sequencing analysis, and immunohistochemistry was used to determine p53 protein expression and Mib-1 proliferation index. We found a mutation frequency of 14.3%. Nine liposarcomas (21%) were p53 immunopositive, and 11 (26.2%) had at least one p53 alteration. In myxoid liposarcomas, p53 alterations are not relevant to the presence or absence of round cell components. Pleomorphic liposarcomas showed a significantly higher proliferation index and more p53 alterations than myxoid or well-differentiated variants (P<0.001). When the Cox's regression analysis tumors of grade III histology (P = 0.005) was performed, the pleomorphic subtype (P = 0.016) and liposarcomas of retroperitoneal localization (P = 0.015) showed a significantly poorer prognosis. Moreover, we found that p53 alterations and high proliferation index correlated significantly with reduced overall survival. Their prognostic value seemed to be higher in myxoid than in pleomorphic liposarcomas. The metastasis-free survival was reduced in patients who had liposarcomas with p53 alterations (P = 0.171) or elevated proliferation index (P<0.016), reflecting a more aggressive behavior. In conclusion, the determination of p53 alterations and/or Mib-1 proliferation index is useful for assessing the prognosis of patients with liposarcomas and may especially be helpful in dividing different prognostic groups for patients with myxoid variants. (+info)

The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (5/347)

Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12q13-15, whereas well differentiated liposarcomas (WDL) show supernumerary ring and giant marker chromosomes, known to contain amplified 12q sequences. The tight correlation between the presence of ring chromosomes and both amplification and overexpression of MDM2 and CDK4 genes suggests the exploration of the possibility that immunocytochemistry (ICC) might assist in the differential diagnosis of lipoma-like well differentiated liposarcomas (LL-WDL) and large deep-seated lipomas (LDSL). For this purpose, 21 cases of the former and 19 cases of the latter tumours were analysed by ICC and, according to the availability of material, by molecular and cytogenetic approaches. All lipomas displayed a null MDM2/CDK4 phenotype, whereas all LL-WDL showed MDM2/CDK4 or CDK4 phenotypes. Southern blot analysis performed on 16 suitable cases, complemented by fluorescence in situ hybridization and classical cytogenetic analysis in 11 cases, was consistent with, and further supported the immunophenotyping data. In conclusion, MDM2/CDK4 product-based immunophenotyping appears to represent a valuable method for the categorization of arguable LDSL. (+info)

Influence of biologic factors and anatomic site in completely resected liposarcoma. (6/347)

PURPOSE: Soft tissue sarcoma (STS) encompasses a group of neoplasms that are anatomically and biologically diverse. Retroperitoneal/visceral (RP/V) tumors have a poorer prognosis than extremity/trunk (E/T) lesions, and this has been attributed to frequent presentation with tumors of large size and multiorgan involvement that precludes complete resection. The worse prognosis that is associated with RP/V tumors has also been thought to be histopathologically dependent and not necessarily related to anatomic site. The aim of this study was to determine the role of anatomic site and biologic features in prognosis and outcome in patients after complete resection by examining a large cohort of STS patients with a single histopathology, ie, liposarcoma. METHODS: All patients who were treated for liposarcoma from July 1, 1982, through July 1, 1998, were included. Univariate analyses were performed using log-rank test and Kaplan-Meier estimates, and multivariate analyses were performed using Cox regression. The three end points examined were local recurrence (LR), distant recurrence, and disease-specific survival (DSS). RESULTS: Seven hundred twenty patients with liposarcoma were evaluated, and of these, 460 had completely resected primary or completely resected locally recurrent disease. Breakdown of anatomic site was 65% E/T (n = 301) and 35% RP/V (n = 159). The median follow-up period for patients who underwent complete resection was 42 months (range, 1 to 194 months). We found that RP/V site is a poor prognosticator that is independent of patient sex and age; tumor size, grade, and margin; and recurrent presentation. Sixty-nine percent of patients with RP/V tumors who died had local disease only and no distant metastasis at the time of death. CONCLUSION: In liposarcoma, tumor location exerts as strong an influence on prognosis as biology. In contrast to extremity liposarcoma, LR without distant metastasis often results in death for patients with RP/V tumors. For these patients, local control accomplished by complete surgical resection +/- adjuvant radiation therapy should impact strongly on DSS. (+info)

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. (7/347)

The characteristic t(12;16)(q13;p11) chromosomal translocation, which leads to gene fusion that encodes the FUS-CHOP chimeric protein, is associated with human liposarcomas. The altered expression of FUS-CHOP has been implicated in a characteristic subgroup of human liposarcomas. We have introduced the FUS-CHOP transgene into the mouse genome in which the expression of the transgene is successfully driven by the elongation factor 1alpha (EF1alpha) promoter to all tissues. The consequent overexpression of FUS-CHOP results in most of the symptoms of human liposarcomas, including the presence of lipoblasts with round nuclei, accumulation of intracellular lipid, induction of adipocyte-specific genes and a concordant block in the differentiation program. We have demonstrated that liposarcomas in the FUS-CHOP transgenic mice express high levels of the adipocyte regulatory protein PPARgamma, whereas it is not expressed in embryonic fibroblasts from these animals following induction to differentiation toward the adipocyte lineage, indicating that the in vitro system does not really reflect the in vivo situation and the developmental defect is downstream of PPARgamma expression. No tumors of other tissues were found in these transgenic mice despite widespread activity of the EF1alpha promoter. This establishes FUS-CHOP overexpression as a key determinant of human liposarcomas and provide the first in vivo evidence for a link between a fusion gene created by a chromosomal translocation and a solid tumor. (+info)

Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. (8/347)

Multifocal presentation, defined as the presence of tumor at two or more anatomically separate sites, before the manifestation of disease in sites where sarcomas usually metastasize (e.g., lungs) occurs in about 1% of extremity soft tissue sarcomas (STSs). Debate still persists whether multifocal STSs represent an unusual pattern of metastasis or multiple separate primary tumors. Among STSs with multifocal presentation, myxoid liposarcoma is the predominant histological type. This subtype of liposarcoma contains the specific t(12;16) chromosomal translocation, which results in rearrangement of the TLS and CHOP genes that is clone specific at the DNA level. We, therefore, sought to address the question of clonality by molecular analysis in six patients who presented with either synchronous or metachronous multifocal myxoid liposarcoma. In all six cases, adequate frozen tumor was available for DNA extraction from at least two distinct anatomical sites. Southern blot analysis using CHOP, TLS, and EWS cDNA probes was performed on genomic DNA. Five cases contained a TLS-CHOP rearrangement, and one case had the variant EWS-CHOP fusion (seen in <5% of cases). The size of the rearranged CHOP fragment differed among the six patients, as expected, but was identical in all anatomically separate tumor samples from each patient. Likewise, the sizes of the rearranged bands observed with either the TLS or EWS probes supported the monoclonality of all cases. Our results confirm the monoclonal origin of multifocal myxoid liposarcoma, establishing the metastatic nature of distant soft tissue lesions in these cases. It remains unclear whether this unusual pattern of metastasis represents an intrinsic property of this subset of myxoid liposarcoma or merely a rare chance occurrence. The clinical outcomes observed in this small series suggest that the prognosis of multifocal myxoid liposarcoma is poor, regardless of its often bland or "low-grade" histological appearance. (+info)

Liposarcoma is a type of soft tissue sarcoma, which is a cancer that develops in the soft tissues of the body, such as fat, muscle, nerves, blood vessels, and fibrous tissues. Specifically, liposarcoma arises from fat cells (adipocytes) or their precursors.

There are several subtypes of liposarcoma, which differ in their appearance under the microscope, genetic features, and clinical behavior. These include well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic liposarcomas. The most common sites for liposarcoma are the thigh, retroperitoneum (the area behind the abdominal cavity), and the buttock.

Liposarcomas can grow slowly or rapidly, and they may spread to other parts of the body (metastasize) through the bloodstream or lymphatic system. Treatment typically involves surgical removal of the tumor, often followed by radiation therapy and/or chemotherapy. The prognosis for liposarcoma depends on several factors, including the type and grade of the tumor, its size and location, and whether it has spread to other parts of the body.

Liposarcoma, myxoid type, is a specific subtype of liposarcoma, which is a malignant (cancerous) tumor that develops from fat cells. Myxoid liposarcoma is characterized by the presence of a gel-like substance in the tumor tissue. It usually occurs in deep soft tissues, such as muscles, tendons, and ligaments, and can be found in various parts of the body, but it most commonly affects the thigh.

Myxoid liposarcoma tends to grow slowly and has a better prognosis compared to other subtypes of liposarcoma. However, it can still metastasize (spread) to other parts of the body, such as the lungs, bones, and lymph nodes. Treatment typically involves surgical removal of the tumor, with radiation therapy and/or chemotherapy used in some cases to help reduce the risk of recurrence or spread.

It's important to note that while I strive to provide accurate information, my responses should not be used as a substitute for professional medical advice, diagnosis, or treatment.

FUS (Fused in Sarcoma) is a protein that in humans is encoded by the FUS gene. It is primarily located in the nucleus of the cell, but can also be found in the cytoplasm. FUS belongs to the family of RNA-binding proteins, which means it has the ability to bind to RNA molecules and play a role in post-transcriptional regulation of gene expression.

FUS has several functions, including:

1. Transcriptional regulation: FUS can interact with transcription factors and modulate the transcription of genes.
2. mRNA processing: FUS is involved in various aspects of mRNA processing, such as splicing, transport, localization, and stability.
3. DNA repair: FUS plays a role in DNA damage response and repair mechanisms.
4. Translational regulation: FUS can also regulate translation by interacting with ribosomes and other translational factors.

Mutations in the FUS gene have been associated with several neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). These mutations often lead to an abnormal cytoplasmic accumulation of FUS protein, which can form aggregates and contribute to the pathogenesis of these diseases.

Retroperitoneal neoplasms refer to abnormal growths or tumors that develop in the retroperitoneal space. This is the area located behind the peritoneum, which is the membrane that lines the abdominal cavity and covers the abdominal organs. The retroperitoneal space contains several vital structures such as the kidneys, adrenal glands, pancreas, aorta, and lymphatic vessels.

Retroperitoneal neoplasms can be benign or malignant (cancerous). Malignant retroperitoneal neoplasms are often aggressive and can invade surrounding tissues and organs, leading to various complications. Common types of retroperitoneal neoplasms include lymphomas, sarcomas, and metastatic tumors from other primary sites. Symptoms may vary depending on the size and location of the tumor but can include abdominal or back pain, weight loss, and swelling in the legs. Diagnosis typically involves imaging studies such as CT scans or MRI, followed by a biopsy to determine the type and grade of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Neoplasms in adipose tissue refer to abnormal and excessive growths of cells that form tumors within the fatty connective tissue. These neoplasms can be benign or malignant (cancerous). Benign neoplasms, such as lipomas, are slow-growing and typically do not spread to other parts of the body. Malignant neoplasms, on the other hand, are cancerous and can invade surrounding tissues and spread to distant sites in the body (metastasis). An example of a malignant neoplasm in adipose tissue is liposarcoma. It's important to note that while some neoplasms may not cause any symptoms, others can cause pain, swelling or other uncomfortable sensations, and therefore should be evaluated by a medical professional for proper diagnosis and treatment.

A lipoma is a common, benign (non-cancerous) soft tissue growth. It is composed of adipose or fatty tissue and typically found just beneath the skin, but they can also occur deeper within the body. Lipomas are usually round, moveable, and painless, although they may cause discomfort if they grow large enough to put pressure on nearby nerves or if they're located in a sensitive area. They generally grow slowly over time. Surgical removal is an option if the lipoma becomes bothersome or grows significantly in size. It's important to note that while lipomas are typically harmless, any new lumps or bumps should be evaluated by a healthcare professional to confirm the diagnosis and rule out other more serious conditions.

Soft tissue neoplasms refer to abnormal growths or tumors that develop in the soft tissues of the body. Soft tissues include muscles, tendons, ligaments, fascia, nerves, blood vessels, fat, and synovial membranes (the thin layer of cells that line joints and tendons). Neoplasms can be benign (non-cancerous) or malignant (cancerous), and their behavior and potential for spread depend on the specific type of neoplasm.

Benign soft tissue neoplasms are typically slow-growing, well-circumscribed, and rarely spread to other parts of the body. They can often be removed surgically with a low risk of recurrence. Examples of benign soft tissue neoplasms include lipomas (fat tumors), schwannomas (nerve sheath tumors), and hemangiomas (blood vessel tumors).

Malignant soft tissue neoplasms, on the other hand, can grow rapidly, invade surrounding tissues, and may metastasize (spread) to distant parts of the body. They are often more difficult to treat than benign neoplasms and require a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy. Examples of malignant soft tissue neoplasms include sarcomas, such as rhabdomyosarcoma (arising from skeletal muscle), leiomyosarcoma (arising from smooth muscle), and angiosarcoma (arising from blood vessels).

It is important to note that soft tissue neoplasms can occur in any part of the body, and their diagnosis and treatment require a thorough evaluation by a healthcare professional with expertise in this area.

Transcription Factor CHOP, also known as DNA Binding Protein C/EBP Homologous Protein or GADD153 (Growth Arrest and DNA Damage-inducible protein 153), is a transcription factor that is involved in the regulation of gene expression in response to various stress stimuli, such as endoplasmic reticulum (ER) stress, hypoxia, and DNA damage.

CHOP is a member of the C/EBP (CCAAT/enhancer-binding protein) family of transcription factors, which bind to specific DNA sequences called cis-acting elements in the promoter regions of target genes. CHOP can form heterodimers with other C/EBP family members and bind to their target DNA sequences, thereby regulating gene expression.

Under normal physiological conditions, CHOP is expressed at low levels. However, under stress conditions, such as ER stress, the expression of CHOP is upregulated through the activation of the unfolded protein response (UPR) signaling pathways. Once activated, CHOP can induce the transcription of genes involved in apoptosis, cell cycle arrest, and oxidative stress response, leading to programmed cell death or survival, depending on the severity and duration of the stress signal.

Therefore, CHOP plays a critical role in maintaining cellular homeostasis by regulating gene expression in response to various stress stimuli, and its dysregulation has been implicated in several pathological conditions, including neurodegenerative diseases, cancer, and metabolic disorders.

Muscle neoplasms are abnormal growths or tumors that develop in the muscle tissue. They can be benign (non-cancerous) or malignant (cancerous). Benign muscle neoplasms are typically slow-growing and do not spread to other parts of the body, while malignant muscle neoplasms, also known as soft tissue sarcomas, can grow quickly, invade nearby tissues, and metastasize (spread) to distant parts of the body.

Soft tissue sarcomas can arise from any of the muscles in the body, including the skeletal muscles (voluntary muscles that attach to bones and help with movement), smooth muscles (involuntary muscles found in the walls of blood vessels, digestive tract, and other organs), or cardiac muscle (the specialized muscle found in the heart).

There are many different types of soft tissue sarcomas, each with its own set of characteristics and prognosis. Treatment for muscle neoplasms typically involves a combination of surgery, radiation therapy, and chemotherapy, depending on the type, size, location, and stage of the tumor.

The spermatic cord is a fibrous structure that contains the vas deferens, blood vessels, nerves, and lymphatics, which provide passage for these structures between the abdomen and the scrotum in males. It is covered by several layers of protective sheaths, including the internal spermatic fascia, cremasteric fascia, and external spermatic fascia. The spermatic cord allows the testicles to be located outside the body, which helps maintain a cooler temperature for optimal sperm production.

Genital neoplasms in males refer to abnormal growths or tumors that develop in the male reproductive organs. These can be benign (non-cancerous) or malignant (cancerous).

Malignant genital neoplasms are often referred to as genital cancers. The most common types of male genital cancers include:

1. Penile Cancer: This occurs when cancer cells form in the tissues of the penis.
2. Testicular Cancer: This forms in the testicles (testes), which are located inside the scrotum.
3. Prostate Cancer: This is a common cancer in men, forming in the prostate gland, which is part of the male reproductive system that helps make semen.
4. Scrotal Cancer: This is a rare form of cancer that forms in the skin or tissue of the scrotum.
5. Penile Intraepithelial Neoplasia (PeIN): This is not cancer, but it is considered a pre-cancerous condition of the penis.

Early detection and treatment of genital neoplasms can significantly improve the prognosis. Regular self-examinations and medical check-ups are recommended, especially for individuals with risk factors such as smoking, HIV infection, or a family history of these cancers.

Sarcoma is a type of cancer that develops from certain types of connective tissue (such as muscle, fat, fibrous tissue, blood vessels, or nerves) found throughout the body. It can occur in any part of the body, but it most commonly occurs in the arms, legs, chest, and abdomen.

Sarcomas are classified into two main groups: bone sarcomas and soft tissue sarcomas. Bone sarcomas develop in the bones, while soft tissue sarcomas develop in the soft tissues of the body, such as muscles, tendons, ligaments, fat, blood vessels, and nerves.

Sarcomas can be further classified into many subtypes based on their specific characteristics, such as the type of tissue they originate from, their genetic makeup, and their appearance under a microscope. The different subtypes of sarcoma have varying symptoms, prognoses, and treatment options.

Overall, sarcomas are relatively rare cancers, accounting for less than 1% of all cancer diagnoses in the United States each year. However, they can be aggressive and may require intensive treatment, such as surgery, radiation therapy, and chemotherapy.

Human chromosome pair 12 consists of two rod-shaped structures present in the nucleus of each cell in the human body. Each chromosome is made up of DNA tightly coiled around histone proteins, forming a complex structure called a chromatin.

Chromosomes come in pairs, with one chromosome inherited from each parent. In humans, there are 23 pairs of chromosomes, for a total of 46 chromosomes in each cell. Chromosome pair 12 is the 12th pair of autosomal chromosomes, meaning they are not sex chromosomes (X or Y).

Chromosome 12 is a medium-sized chromosome and contains an estimated 130 million base pairs of DNA. It contains around 1,200 genes that provide instructions for making proteins and regulating various cellular processes. Some of the genes located on chromosome 12 include those involved in metabolism, development, and response to environmental stimuli.

Abnormalities in chromosome 12 can lead to genetic disorders, such as partial trisomy 12q, which is characterized by an extra copy of the long arm of chromosome 12, and Jacobsen syndrome, which is caused by a deletion of the distal end of the long arm of chromosome 12.

The mesocolon is a peritoneal fold that attaches the colon to the posterior abdominal wall. It contains blood vessels, lymphatics, and nerves that supply the colon. The mesocolon allows for the mobility and flexibility of the colon within the abdominal cavity. There are several parts of the mesocolon, including the mesentery of the ascending colon (right mesocolon), the transverse mesocolon, and the mesentery of the descending and sigmoid colon (left mesocolon).

I apologize for any confusion, but "dioxoles" is not a medical term or concept. It is a chemical term that refers to a specific type of organic compound containing a dioxole ring, which is a six-membered ring consisting of two oxygen atoms and two carbon atoms. Dioxoles can be found in various natural and synthetic substances, but they are not typically relevant to medical definitions or concepts.

If you have any questions related to medical terminology or concepts, I would be happy to help answer them for you.

Cell dedifferentiation is a process by which a mature, specialized cell reverts back to an earlier stage in its developmental lineage, regaining the ability to divide and differentiate into various cell types. This phenomenon is typically observed in cells that have been damaged or injured, as well as during embryonic development and certain disease states like cancer. In the context of tissue repair and regeneration, dedifferentiation allows for the generation of new cells with the potential to replace lost or damaged tissues. However, uncontrolled dedifferentiation can also contribute to tumor formation and progression.

Mediastinal neoplasms refer to abnormal growths or tumors located in the mediastinum, which is the central compartment of the thoracic cavity that lies between the lungs and contains various vital structures such as the heart, esophagus, trachea, blood vessels, lymph nodes, and nerves. Mediastinal neoplasms can be benign (non-cancerous) or malignant (cancerous), and they can arise from any of the tissues or organs within the mediastinum.

Benign mediastinal neoplasms may include thymomas, lipomas, neurofibromas, or teratomas, among others. These tumors are typically slow-growing and rarely spread to other parts of the body. However, they can still cause symptoms or complications by compressing adjacent structures within the mediastinum, such as the airways, blood vessels, or nerves.

Malignant mediastinal neoplasms are cancerous tumors that can invade and destroy surrounding tissues and may spread (metastasize) to other parts of the body. Common types of malignant mediastinal neoplasms include thymic carcinomas, lymphomas, germ cell tumors, and neuroendocrine tumors. These tumors often require aggressive treatment, such as surgery, radiation therapy, and chemotherapy, to control their growth and spread.

It is important to note that mediastinal neoplasms can present with various symptoms depending on their location, size, and type. Some patients may be asymptomatic, while others may experience cough, chest pain, difficulty breathing, hoarseness, or swallowing difficulties. A thorough diagnostic workup, including imaging studies and biopsies, is necessary to confirm the diagnosis and determine the best course of treatment for mediastinal neoplasms.

Tetrahydroisoquinolines (TIQs) are not a medical condition, but rather a class of organic compounds that have been studied in the field of medicine and neuroscience. TIQs are naturally occurring substances found in various foods, beverages, and plants, as well as produced endogenously in the human body. They have been shown to have various pharmacological activities, including acting as weak psychoactive agents, antioxidants, and inhibitors of certain enzymes. Some TIQs have also been implicated in the pathophysiology of certain neurological disorders such as Parkinson's disease. However, more research is needed to fully understand their roles and potential therapeutic applications.

Leiomyosarcoma is a type of cancer that arises from the smooth muscle cells, which are responsible for the involuntary contractions of various organs and blood vessels. It most commonly occurs in the uterus, soft tissues (such as muscles and fat), and the gastrointestinal tract.

Leiomyosarcomas can vary in their aggressiveness and may spread to other parts of the body (metastasize) through the bloodstream or lymphatic system. The prognosis for leiomyosarcoma depends on several factors, including the location and size of the tumor, the patient's age and overall health, and the extent of metastasis. Treatment typically involves surgical removal of the tumor, along with radiation therapy and/or chemotherapy to help prevent recurrence or spread of the cancer.

Proto-oncogene proteins, such as c-MDM2, are normal cellular proteins that play crucial roles in regulating various cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). When these genes undergo mutations or are overexpressed, they can become oncogenes, which contribute to the development of cancer.

The c-MDM2 protein is a key regulator of the cell cycle and is involved in the negative regulation of the tumor suppressor protein p53. Under normal conditions, p53 helps prevent the formation of tumors by inducing cell cycle arrest or apoptosis in response to DNA damage or other stress signals. However, when c-MDM2 is overexpressed or mutated, it can bind and inhibit p53, leading to uncontrolled cell growth and increased risk of cancer development.

In summary, proto-oncogene proteins like c-MDM2 are important regulators of normal cellular processes, but when they become dysregulated through mutations or overexpression, they can contribute to the formation of tumors and cancer progression.

Malignant fibrous histiocytoma (MFH) is not a specific type of histiocytoma; rather, it is a type of soft tissue sarcoma. Histiocytomas are benign tumors that arise from cells called histiocytes, which are part of the immune system. MFH, on the other hand, is a malignant (cancerous) tumor that can arise in various types of soft tissues, such as muscle, fat, tendons, and ligaments.

MFH was once thought to originate from histiocytes, but more recent research suggests that it may actually arise from undifferentiated mesenchymal cells, which are capable of developing into a variety of different cell types. MFH is the most common type of soft tissue sarcoma in adults over the age of 50 and typically presents as a painless mass in the extremities or retroperitoneum (the area in the back of the abdomen).

The tumor is characterized by the presence of fibroblastic and histiocytic-like cells, which can be quite pleomorphic (varied in shape and size) and may contain numerous mitotic figures (indicating rapid cell division). Treatment typically involves surgical excision, often followed by radiation therapy and/or chemotherapy. The prognosis for MFH depends on several factors, including the tumor's location, size, grade (degree of differentiation), and the patient's age and overall health.

Benign fibrous histiocytoma (BFH) is a common benign tumor of the skin and superficial soft tissues. It primarily affects middle-aged adults and is more prevalent in men than women. The exact cause of BFH is unknown, but it's thought to arise from dermal fibroblasts or histiocytes.

Medical Definition: Benign Fibrous Histiocytoma (BFH) is a benign, slowly growing, solitary cutaneous or subcutaneous nodular tumor predominantly composed of a mixture of fibroblastic and histiocytic-like cells. The tumor typically presents as a well-circumscribed, firm, dome-shaped papule or nodule, ranging in size from a few millimeters to several centimeters. Histologically, BFH is characterized by the proliferation of spindle-shaped fibroblasts and histiocytes arranged in a storiform pattern, along with variable amounts of collagen deposition, multinucleated giant cells, and hemosiderin deposits. The lesion usually has a pushing border with no invasion into the surrounding tissues. BFH generally follows a benign clinical course, with local recurrence being uncommon following complete surgical excision.

... dedifferentiated liposarcoma (DD-LPS); 3) myxoid liposarcoma; 4) pleomorphic liposarcoma; and 5) myxoid pleomorphic liposarcoma ... Pleomorphic liposarcomas (PLS), which account for 5% to 10% of all liposarcoma cases, are fast-growing, usually large (>5 cm), ... Myxoid pleomorphic liposarcoma (MPL) is an exceptionally rare and highly aggressive form of the liposarcomas that develops in ... Myxoid pleomorphic liposarcoma (originally termed pleomorphic myxoid liposarcoma) was first described in a large 2009 study of ...

https://en.wikipedia.org/wiki/Liposarcoma

Myxoid liposarcomas are the second-most common type of liposarcoma, representing 30-40% of all liposarcomas in the limbs, ... This fusion gene is notated as t(12;22)(q13;12). Micrograph of myxoid liposarcoma. H&E stain MRI of myxoid liposarcoma of high ... Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance Efficacy of first-line doxorubicin and ... Crozat A, Aman P, Mandahl N, Ron D (1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature ...

https://en.wikipedia.org/wiki/Myxoid_liposarcoma

MTM1 Myxoid liposarcoma; 613488; DDIT3 Myxoma, intracardiac; 255960; PRKAR1A N syndrome; 310465; POLA N-Acetylglutamate ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

It resembles myxoid liposarcoma. Benign lipoblastomatosis List of cutaneous conditions Rapini, Ronald P.; Bolognia, Jean L.; ... ISBN 978-1-4160-2999-1. Orvieto E, Furlanetto A, Laurino L, Dei Tos AP (November 2001). "Myxoid and round cell liposarcoma: a ...

https://en.wikipedia.org/wiki/Myxoid_lipoblastoma

Cohen, G (1958). "Primary Liposarcoma of bone. The angiography findings and doubts as to its intramedullary origin". British ...

https://en.wikipedia.org/wiki/George_Getzel_Cohen

McDonald, A. G.; Cin, P. D.; Ganguly, A.; Campbell, S.; Imai, Y.; Rosenberg, A. E.; Oliva, E. (2011). "Liposarcoma Arising in ... lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into liposarcoma. ...

https://en.wikipedia.org/wiki/Leiomyoma

Malignant transformation of lipomas into liposarcomas is very rare, and most liposarcomas are not produced from pre-existing ... Liposarcoma is found in 1% of lipomas and is more likely to occur in lesions of the lower extremities, shoulders, and ... Ultrasonography of a liposarcoma mimicking lipoma. A homogeneous hypoechoic mass presenting with the same appearance of lipoma ... T1 MRI of the same lipoma: High intensity signal mass with regions of ill-defined margins Ultrasonography of a liposarcoma for ...

https://en.wikipedia.org/wiki/Lipoma

"Research Activities - Liposarcoma of the cervix". Archived from the original on 24 September 2015. Retrieved 5 August 2015. " ... Some of his published books and researches include: Liposarcoma of the cervix Gastric carcinoma in Plateau State, Nigeria ...

https://en.wikipedia.org/wiki/John_Obafunwa

Defifferentiated liposarcoma: MDM2 and CDK4 proteins. Poorly differentiated carcinoma (i.e. grade 3 or 4 carcinoma): MUC1 (also ... These tumors and features are: Pleomorphic liposarcoma: At least some tumor cells have features of pleomorphic lipoblasts, i.e ... blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma". BMC ...

https://en.wikipedia.org/wiki/Undifferentiated_pleomorphic_sarcoma

... dedifferentiated liposarcoma, myxoid sarcoma, pleomorphic liposarcoma, and myxoid pleomorphic liposarcoma Atypical lipomatous ... Liposarcoma (includes the following varieties: atypical lipomatous tumor/well-differentiated liposarcoma, ... Many liposarcomas are associated with duplication of part of chromosome 12, which results in extra copies of known cancer- ... Liposarcoma treatment consists of surgical resection, with chemotherapy not being used outside of the investigative setting. ...

https://en.wikipedia.org/wiki/Sarcoma

"Trabectedin Superior to Dacarbazine for Leiomyosarcoma, Liposarcoma". Cancer Network. 21 September 2015. Archived from the ... and that the clinical efficacy data were mainly based on patients with liposarcoma and leiomyosarcoma. However, the pivotal ... for the treatment of liposarcoma and leiomyosarcoma that is either unresectable or has metastasized. Patients must have ... DNA binding of the oncogenic transcription factor FUS-CHOP and reverses the transcriptional program in myxoid liposarcoma. By ...

https://en.wikipedia.org/wiki/Trabectedin

They were also the first to demonstrate the growth characteristics of fat cells grown from a liposarcoma. Dr. Murray and ... Murray, Margaret R.; Stout, Arthur Purdy (1943). "Characteristics of a Liposarcoma Grown in Vitro". American Journal of ...

https://en.wikipedia.org/wiki/Margaret_Ransone_Murray

In the following election, Ford was forced to drop out because of treatment for pleomorphic liposarcoma, a rare form of cancer ... What is a pleomorphic liposarcoma?". Toronto Star. thestar.com. Retrieved March 18, 2016. Mayor's biography http://www1.toronto ...

https://en.wikipedia.org/wiki/Politics_of_Toronto

The next day, Doug Ford advised reporters that the tumour had been found to be cancerous and consistent with liposarcoma (the ... Pelley, Lauren (September 17, 2014). "Rob Ford's diagnosis: What is a pleomorphic liposarcoma?". Toronto Star. Retrieved March ... Deaths from liposarcoma, Mayors of Toronto, People from Etobicoke, Toronto city councillors, Ford political family, Right-wing ... revealed that Ford had been diagnosed with pleomorphic liposarcoma, a rare form of cancer that arises in adipose tissue (fat). ...

https://en.wikipedia.org/wiki/Rob_Ford

Ford was diagnosed with pleomorphic liposarcoma cancer in 2014, and went in for surgery on May 11, 2015. In a statement, Ford ... "Rob Ford's diagnosis: What is a pleomorphic liposarcoma?". Toronto Star. "Former Toronto mayor Rob Ford undergoing 10-hour ... "Rob Ford's diagnosis: What is a pleomorphic liposarcoma?". The Star. 17 September 2014. Retrieved 7 May 2021. "Latest Breaking ...

https://en.wikipedia.org/wiki/Not_My_Time_(song)

Doyle LA, Tao D, Mariño-Enríquez A (September 2014). "STAT6 is amplified in a subset of dedifferentiated liposarcoma". Modern ... Amplification STAT6 is amplified in a subset of dedifferentiated liposarcoma. Interleukin 4 GRCh38: Ensembl release 89: ...

https://en.wikipedia.org/wiki/STAT6

Mulholland, Angela (March 22, 2016). "Rob Ford's illness shone spotlight on rare cancer: liposarcoma". CTV News. Bell Media. ... 18 months after being diagnosed with pleomorphic liposarcoma cancer. March 22 Ford's office made an official statement about ...

https://en.wikipedia.org/wiki/Timeline_of_Rob_Ford_video_scandal

Crozat A, Aman P, Mandahl N, Ron D (June 1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". ... Mutations or fusions of CHOP (e.g. with FUS to form FUS-CHOP) can cause Myxoid liposarcoma. GRCh38: Ensembl release 89: ... November 1992). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)". Genes, ... "Fusion of the EWS and CHOP genes in myxoid liposarcoma". Oncogene. 12 (3): 489-94. PMID 8637704. Li G, Scull C, Ozcan L, Tabas ...

https://en.wikipedia.org/wiki/DNA_damage-inducible_transcript_3

Liposarcoma-like and chondroid foci can be an additional finding. Fibrosarcoma-like and fibrous histiocytoma-like areas can be ...

https://en.wikipedia.org/wiki/Ectomesenchymoma

10 March 2011). "Liposarcoma in children and young adults: a multi-institutional experience". Pediatric Blood & Cancer. 57 (7 ...

https://en.wikipedia.org/wiki/Andrea_Hayes-Jordan

In the Spring of 2016, Davies was diagnosed with liposarcoma. Statistics accurate as of December 22, 2021. International goals ...

https://en.wikipedia.org/wiki/Charlie_Davies

Chad Brown, 52, American professional poker player and actor, liposarcoma. Manuel Cardona, 79, Spanish physicist. Wayne K. ...

https://en.wikipedia.org/wiki/Deaths_in_July_2014

... , sold under the brand name Halaven, is an anticancer medication used to treat breast cancer and liposarcoma. The most ... adults with unresectable liposarcoma who have received prior anthracycline containing therapy (unless unsuitable) for advanced ... "FDA approves first drug to show survival benefit in liposarcoma". U.S. Food and Drug Administration (FDA) (Press release). 28 ... "U.S. FDA Approves Eisai's Anticancer Agent Halaven For The Treatment Of Advanced Liposarcoma" (Press release). Eisai Co., Ltd. ...

https://en.wikipedia.org/wiki/Eribulin

Atypical lipomatous tumors (ALTs) are a type of well-differentiated liposarcoma. The term ALT is often applied to tumors ... Unlike less well-differentiated liposarcomas which are malignant, ALTs, while sometimes locally invasive and recurring after ... "A well-differentiated liposarcoma with a new type of chromosome 12-derived markers". Cancer Genetics and Cytogenetics. 131 (1 ... or eye socket whereas the term well-differentiated liposarcomas is applied to tumors in less surgically accessible, deep, and ...

https://en.wikipedia.org/wiki/Small_supernumerary_marker_chromosome

Rob Ford, 46, Canadian politician, Mayor of Toronto (2010-2014), liposarcoma. Rita Gam, 88, American actress (The Thief, Klute ...

https://en.wikipedia.org/wiki/Deaths_in_March_2016

"Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)". Crozat A, Aman P, Mandahl N, Ron D (June 1993). " ... Powers CA, Mathur M, Raaka BM, Ron D, Samuels HH (1998). "TLS (translocated-in-liposarcoma) is a high-affinity interactor for ... Powers CA, Mathur M, Raaka BM, Ron D, Samuels HH (January 1998). "TLS (translocated-in-liposarcoma) is a high-affinity ... RNA-binding protein FUS/TLS (FUsed in Sarcoma/Translocated in LipoSarcoma), also known as heterogeneous nuclear ...

https://en.wikipedia.org/wiki/RNA-binding_protein_FUS

Through these walks, the foundation has raised over 2 million dollars for liposarcoma research. Liposarcoma is an "orphan" ... The Wendy Walk is a not-for-profit organization whose mission is to raise funds and awareness for liposarcoma, a rare form of ... Progress has been made in finding the root cause of liposarcoma, largely as a result of funding provided by The Wendy Walk and ... participants supported by thousands of donors raised over three quarters of a million dollars in the fight against liposarcoma ...

https://en.wikipedia.org/wiki/The_Wendy_Walk

Hokie Gajan, 56, American football player and broadcaster (New Orleans Saints), liposarcoma. Mohsen Gheytaslou, 25-26, Iranian ...

https://en.wikipedia.org/wiki/Deaths_in_April_2016

Strand died of liposarcoma on November 29, 2014, in Brooklyn, New York. Many of Strand's poems are nostalgic in tone, evoking ... Deaths from liposarcoma, Fulbright alumni, Iowa Writers' Workshop alumni, Iowa Writers' Workshop faculty, Jewish American poets ...

https://en.wikipedia.org/wiki/Mark_Strand

"SARC041: Study of Abemaciclib Versus Placebo in Patients With Advanced Dedifferentiated Liposarcoma". www.clinicaltrials.gov. ... The SARC041 study compares abemaciclib versus placebo in patients with advanced dedifferentiated liposarcoma. The CYCLONE 3 ...

https://en.wikipedia.org/wiki/Abemaciclib

https://en.wikipedia.org/wiki/Liposarcoma

Liposarcoma is one of the least frequent nonrhabdomyosarcoma soft tissue sarcomas to occur in childhood; it comprises less than ... encoded search term (Pediatric Liposarcoma) and Pediatric Liposarcoma What to Read Next on Medscape ... Pediatric Liposarcoma Medication. Updated: Jul 23, 2018 * Author: Alexander Gozman, MD; Chief Editor: Max J Coppes, MD, PhD, ... Liposarcoma in patients younger than or equal to 22 years of age. Cancer. 1993 Nov 15. 72(10):3114-9. [QxMD MEDLINE Link]. ...

https://www.medscape.com/answers/987446-168994/what-is-the-role-of-medications-in-the-treatment-of-pediatric-liposarcoma

... see Liposarcoma in the Pediatric Medicine section and Liposarcoma, Soft Tissue in the Radiology section). In adults, it is the ... Primary liposarcoma may be evident as metastatic liposarcoma to the head and neck region, including the gingival mucosa. [27, ... The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. Appl ... encoded search term (Liposarcoma) and Liposarcoma What to Read Next on Medscape ...

https://emedicine.medscape.com/article/1102007-differential

Liposarcoma is the most common soft tissue sarcoma and accounts for approximately 20% of all mesenchymal malignancies. In the ... Spindle cell liposarcoma represents an uncommon variant of well-differentiated liposarcoma. It tends to occur in adults and ... Dedifferentiated liposarcoma is a distinct type of liposarcoma in which transition from low-grade to high-grade nonlipogenic ... liposarcoma, characterized in most cases by a reciprocal translocation t(12;16)(q13;p11); and (3) pleomorphic liposarcoma, ...

https://pubmed.ncbi.nlm.nih.gov/10982304/?dopt=Abstract

I am a 4 year survivor of a liposarcoma behind my left knee, I had it removed and had 8 weeks of radiation, no chemo as they ... I am a 4 year survivor of a liposarcoma behind my left knee, I had it removed and had 8 weeks of radiation, no chemo as they ... From my experience, liposarcoma is self contained (unless left alone and it metatisizes).. I had a somewhat similar initial ... From my experience, liposarcoma is self contained (unless left alone and it metatisizes).. I had a somewhat similar initial ...

https://csn.cancer.org/discussion/183382/liposarcoma

... myxoid liposarcoma and retroperitoneal liposarcoma are explained for patients and practitioners, with patient stories and ... in well-differentiated liposarcoma, 88% in myxoid liposarcoma, and 56% in pleomorphic liposarcoma. Ten-year survival rates are ... Liposarcoma Stories and Support. Teresa has dealt with liposarcoma five times. I have lived so much life between today and my ... Table I: Liposarcoma subtypes Well-differentiated. Includes atypical lipoma Most common subtype (50% of liposarcomas) Low grade ...

https://sarcomahelp.org/liposarcoma.html?tpm=1_2

The results came back this friday that I most likely have a well differentiated liposarcoma located near my L5 in the muscle. ...

https://csn.cancer.org/discussion/288966/newly-found-liposarcoma-please-help

An international team of basic and translational researchers come together to address key questions about liposarcomas. ... Liposarcoma Research. ---Kindred Study. ---Myxoid Liposarcoma. ---Translational Research I. ---Translational Research II. --- ... of liposarcoma; dedifferentiated liposarcoma (DDLPS) comprises approximately 20%; myxoid liposarcoma comprises 30%; and ... Liposarcoma, the second most common type of sarcoma, forms four semi-distinct subclasses: Well-differentiated liposarcoma ( ...

http://www.sarcomahelp.org/research/liposarcoma-translational.html

A D V E R T I S E M E N ...

http://vesalius.com/cfoli_frms.asp?VID=1114&StartFrame=16&tnVID=1115

Mediastinal Pleomorphic Liposarcoma Diagnosed by Fine Needle Aspiration Biopsy: A Case Report Subject Area: Pathology and Cell ... Liposarcoma of the Thyroid: A Case Report with a Review of the Literature Eur Thyroid J (January,2018) ... Established and Experimental Systemic Treatment Options for Advanced Liposarcoma Oncol Res Treat (May,2022) ... Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma with Myxoid Stroma in a Hereditary Retinoblastoma Survivor Ocul Oncol ...

https://karger.com/acy/article-abstract/51/3/440/9317/Mediastinal-Pleomorphic-Liposarcoma-Diagnosed-by?redirectedFrom=fulltext

In this episode, we review the high-yield topic of ⁠Liposarcoma⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠from the Pathology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Orthobullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

https://podcasters.spotify.com/pod/show/orthobullets/embed/episodes/PathologyLiposarcoma-e28c306

Liposarcoma Sarah D Cramer 1 , Kelci L Porter, Mark C Rochat, Catherine G Lamm ... Liposarcoma in an old cat. Tanimoto T, Shirota K, Nakamura M, Une Y, Nomura Y. Tanimoto T, et al. Nihon Juigaku Zasshi. 1987 ... Liposarcoma Sarah D Cramer et al. J Am Vet Med Assoc. 2011. . ... Virus-associated liposarcoma and malignant lymphoma in a kitten ... Well-differentiated Liposarcoma in a Bonnet Macaque (Macaca radiata). Doane CJ, Johnson PJ, Besselsen DG. Doane CJ, et al. Comp ...

http://www.ncbi.nlm.nih.gov/pubmed/21916756

Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single ... Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma Chengli Miao 1 , Ding Liu 2 , Feng Zhang 3 ... Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma Chengli Miao et al. Sci Rep. 2015. . ... Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma. Chen J, Hang Y, Gao Q, Huang X. Chen J, et al. Front ...

https://pubmed.ncbi.nlm.nih.gov/25765001

Retroperitoneal liposarcoma (RLPS) is one of the most common subtypes of retroperitoneal soft tissue sarcomas. It is ... Keywords: Retroperitoneal liposarcoma, patient-derived xenograft (PDX), prognosis, treatment evaluation, tumor biology research ... Establishment and evaluation of retroperitoneal liposarcoma patient-derived xenograft models: an ideal model for preclinical ... Establishment and evaluation of retroperitoneal liposarcoma patient-derived xenograft models: an ideal model for preclinical ...

https://medsci.org/v19p1241

Lipoma and Liposarcoma. Dr. Mark Awh. Clinical History: A 65 year-old male presents with right flank pain and sensation of a ... Atypical lipoma and liposarcoma. Many MR interpreters do not realize that atypical lipomas and well-differentiated liposarcomas ... Although any liposarcoma subtype may contain fatty elements, higher grade tumors such as pleomorphic liposarcomas may contain ... In general, myxoid liposarcomas are mildly heterogeneous on MR images, and pleomorphic liposarcomas are markedly heterogeneous ...

https://radsource.us/lipoma-and-liposarcoma/

... and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and ... Keywords: Liposarcoma, Asian, Prognostic model, Survival. Citation styles. APA Copy. Oh, Y.J., Yi, S.Y., Kim, K.H., Cho, Y.J., ... Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience Yoon Jung Oh ... Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience. J Cancer ...

https://www.jcancer.org/v07p1174

Liposarcoma is the most common soft tissue sarcoma, accounting for approximately 20% of cases. Liposarcomas are only very ... Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma Laurence M. Briski, ... Subject: Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma ... were liposarcomas. Austin and Dupree3 report the largest series, with 13 cases of primary breast liposarcoma. The Table ...

https://meridian.allenpress.com/aplm/article-split/142/2/268/65850/Primary-Breast-Atypical-Lipomatous-Tumor-Well

We describe the case of a 50-year-old man with advanced retroperitoneal liposarcoma who developed irreversible PLD-associated ... Pegylated liposomal doxorubicin-induced renal toxicity in retroperitoneal liposarcoma: a case report and literature review. ... We describe the case of a 50-year-old man with advanced retroperitoneal liposarcoma who developed irreversible PLD-associated ... We describe the case of a 50-year-old man with advanced retroperitoneal liposarcoma who developed irreversible PLD-associated ...

https://experts.umn.edu/en/publications/pegylated-liposomal-doxorubicin-induced-renal-toxicity-in-retrope

Return to Article Details SPECTRUM OF LIPOSARCOMAS-A STUDY OF 106 CASES Download Download PDF ...

https://jamc.ayubmed.edu.pk/jamc/index.php/jamc/article/view/1496/523

... myxoid liposarcoma, round cell liposarcoma, pleomorphic liposarcoma, mixed-type liposarcoma and differentiated liposarcoma. ... Liposarcoma. Liposarcoma is a specific type soft tissue sarcoma that forms tumour in the fat tissue of the body. Soft tissue ... Liposarcoma is comprised of different types such as well-differentiated liposarcoma, ... Patients suffering from liposarcoma will develop painless deep-seated mass in the soft tissue and experience pain and ...

https://www.clinicaltrialsarena.com/projects/halaven-eribulin-mesylate-treatment-advanced-liposarcoma/

Retroperitoneal dedifferentiated liposarcoma recurred within 5 months after the first complete surgical resection under the ... Retroperitoneal dedifferentiated liposarcoma recurred within 5 months after the first complete surgical resection under the ... Extended radical surgical resection of recurrent giant retroperitoneal dedifferentiated liposarcoma: a case report ...

https://www.authorea.com/doi/full/10.22541/au.166332791.19802394

... see Liposarcoma in the Pediatric Medicine section and Liposarcoma, Soft Tissue in the Radiology section). In adults, it is the ... Liposarcoma is a malignancy of fat cells (see Pediatric Liposarcoma and Liposarcoma Imaging). In adults, it is the most common ... Virchow first described liposarcoma in the 1860s.. The development of a liposarcoma from a preexisting benign lipoma is rare. ... Spindle-cell liposarcoma is a rare variant of an atypical lipomatous tumor (ie, well-differentiated liposarcoma), and it must ...

https://emedicine.staging.medscape.com/article/1102007-overview

Liposarcomas are rare neoplasms most often localized in the retroperitoneal space. Due to there localization, slow growth, and ... Surgery remains the main method of treatment considering patients' diagnosed with liposarcomas.The role of chemotherapy in ... Henrics WH, Chu YC, Goldblum JR et al.: Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a ... Histologic subtype and margin of resection predict pat tern of recurence and survival for retroperitoneal liposarcoma. Ann Surg ...

http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.-psjd-doi-10_2478_v10035-010-0069-y

Liposarcoma, Myxoid - 8 Studies Found. Status. Study Recruiting. Study Name: Brostallicin Clinical Trial for Myxoid Liposarcoma ... Study Name: Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas. Condition: Myxoid Liposarcoma of Soft Tissue. ... Condition: Liposarcoma. Date: 2014-09-24. Interventions: Drug: efatutazone Given PO. Recruiting. Study Name: A Pilot Study of ... Condition: Myxoid Liposarcoma. Date: 2008-03-03. Interventions: Drug: Brostallicin Patients will receive Brostallicin ...

https://seniorhealthcarematters.com/clinicaltrials-search.php?q=Liposarcoma%2C+Myxoid

Foods for Dedifferentiated Liposarcoma!. Aug 4, 2023. Introduction Foods for Dedifferentiated Liposarcoma should be ...

https://addon.life/tag/dedifferentiated-liposarcoma/

Myxoid Liposarcoma is a cancer for which foods and supplements recommended and those to avoid must be personalized to ... Tags: diet Myxoid Liposarcoma , foods for Myxoid Liposarcoma , foods to avoid for Myxoid Liposarcoma , Myxoid Liposarcoma , ... Myxoid Liposarcoma genetic , Myxoid Liposarcoma genetic mutations , Myxoid Liposarcoma genetic risk , Myxoid Liposarcoma ... Characteristics of cancers like Myxoid Liposarcoma. All cancers like Myxoid Liposarcoma can be characterized by a unique set of ...

https://addon.life/2023/07/25/foods-for-myxoid-liposarcoma/

Cutaneous Liposarcoma; cutaneous liposarcoma; Liposarcoma of Skin; liposarcoma of skin; Liposarcoma of the Skin; liposarcoma of ... the skin; liposarcoma of zone of skin; Skin Liposarcoma; skin liposarcoma; zone of skin liposarcoma. ... Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2/CDK4 immunostainings.. Ramírez-Bellver JL, López J, ... Primary subcutaneous myxoid liposarcoma: a clinicopathologic review of three cases with molecular confirmation and discussion ...

https://https.ncbi.nlm.nih.gov/medgen/232398

Table 6: Efficacy Results for the Liposarcoma Stratum and All Patients* in Study 2a Liposarcoma Stratum. All Patients*. ... 1.2 Liposarcoma HALAVEN is indicated for the treatment of patients with unresectable or metastatic liposarcoma who have ... 14.2 Liposarcoma 15 REFERENCES 16 HOW SUPPLIED/STORAGE AND HANDLING 17 PATIENT COUNSELING INFORMATION * Sections or subsections ... 1.2 Liposarcoma 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dose 2.2 Dose Modification 2.3 Instructions for Preparation and ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31ce4750-ded5-4a0b-95e9-f229fa6bc822&audience=consumer

Cause of Death: Pleomorphic Liposarcoma. The following celebrities died from the cause: Pleomorphic Liposarcoma. ...

https://www.thecelebritydeaths.com/cause-of-death/pleomorphic-liposarcoma/

Patients with advanced, refractory dedifferentiated liposarcoma (DD-LPS) treated with selinexor showed improvement in ... Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled ...

https://medjournal360.com/sarcoma/selinexor-shows-potential-in-dedifferentiated-liposarcoma/

The round cell form of myxoid liposarcomas also appears to have a relatively poor prognosis: in various retrospective reviews, myxoid liposarcoma was usually found to be low-grade and therefore relatively responsive to chemotherapy whereas high grade (i.e. round cell) myxoid lipsarcoma had higher rates of metastasis, behaved more aggressively, and did not respond well to chemotherapy. (wikipedia.org)
It is important to note, however, that almost all cases of myxoid liposarcomas in pediatric patients have had excellent prognoses. (wikipedia.org)
Myxoid liposarcomas are homogeneous or mildly heterogeneous, and a pseudocapsule can be present. (medscape.com)
1- 5 These tumours show a variable clinical behaviour, with round cell liposarcomas being highly metastatic, poorly differentiated tumours, whereas myxoid liposarcomas are less metastatic, moderately and well differentiated tumours, and are associated with a more favourable survival rate. (bmj.com)
It is fairly similar to a myxoid liposarcoma, and it is believed that myxoid liposarcomas can transgress into round cell liposarcomas. (orthopediconcologist.com)
Most myxoid liposarcomas (MLS) are characterized cytogenetically by a t(12;16)(q13;p11). (lu.se)

While liposarcoma forms are classified as being aggressive and malignant or, in the case of the atypical lipomatous tumor/well-differentiated liposarcoma, as relatively non-aggressive and benign, all five liposarcoma forms can infiltrate locally to injure nearby tissues and organs, occur in surgically inaccessible sites adjacent to vital organs (e.g. the retroperitoneum), recur after surgical removal, and progress to life-threatening diseases. (wikipedia.org)
[ 6 ] Although tumor grade and subtype are considered standard parameters for risk assessment in patients with liposarcoma, pretherapy tumor standardized uptake values obtained by FDG PET imaging was found to be a more useful parameter for risk assessment in liposarcoma compared with tumor grade or subtype. (medscape.com)
While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. (nih.gov)
Well differentiated (WDLPS), also known as atypical lipomatous tumor (ALT), and dedifferentiated liposarcomas (DDLPS) are the most common subtypes. (sarcomahelp.org)
Retroperitoneal liposarcoma is a rare malignant tumor with an incidence of 2.5/1,000,000 individuals ( 1 ). (spandidos-publications.com)
Although the clinical implications of chromosomal aberrations in liposarcomas are incompletely understood, in other malignancies complex chromosomal rearrangements have been shown to alter chromatin folding, architecture, and organization which in turn impact functional genomic processes and the tumor regulatory landscape through altered near- and long-range interactions. (curesarcoma.org)
Liposarcoma - El liposarcoma es un tumor maligno de origen mesodérmico derivado del tejido adiposo y el más frecuente de los sarcomas de partes blandas. (en-academic.com)
Spindle-cell liposarcoma is a rare variant of an atypical lipomatous tumor (ie, well-differentiated liposarcoma), and it must be distinguished from a dedifferentiated liposarcoma with metastatic potential and a benign spindle-cell lipoma. (medscape.com)
Liposarcoma is a lipogenic tumor of large deep-seated connective tissue spaces. (medscape.com)
Introduction Foods for Dedifferentiated Liposarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. (addon.life)
This study will investigate the safety and tolerability of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen (HLA) and tumor antigen status and whose synovial sarcoma, myxoid/round cell liposarcoma (MRCLS), melanoma, urothelial, head and neck, ovarian, gastric (stomach), esophagogastric junction (EGJ), non-small cell lung (NSCLC), or esophageal cancer that express the MAGE-A4 protein. (participaid.co)
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively. (qxmd.com)
O liposarcoma (LPS) é um tumor mesenquimatoso maligno do tecido adiposo. (europubpublications.com)
Liposarcoma is a malignant mesenchymal tumor of adipose tissue. (europubpublications.com)
Liposarcoma is a malignant mesenchymal tumor that most commonly involves the retroperitoneum and lower extremities . (bvsalud.org)
Esophageal liposarcoma is an extremely rare tumor . (bvsalud.org)
Background Liposarcoma, the most frequent soft tissues tumor, is certainly understudied cancers, and limited improvement has been manufactured in the treating metastatic disease. (molecularcircuit.com)
Conclusions Two large-scale kinase screenings discovered novel liposarcoma goals and a FDA-approved inhibitor, ponatinib with apparent anti-liposarcoma activity highlighting its potential therapy for treatment ME0328 manufacture of the dangerous tumor. (molecularcircuit.com)

Oct. 23, 2015 /PRNewswire/ -- Janssen Biotech, Inc. today announced the U.S. Food and Drug Administration (FDA) has approved YONDELIS ® (trabectedin) for the treatment of patients with unresectable (unable to be removed with surgery) or metastatic liposarcoma (LPS) or leiomyosarcoma (LMS) who received a prior anthracycline-containing regimen. (prnewswire.com)
Unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen. (drugs.com)
This research lays the groundwork for any clinical medication trial with ponatinib for individuals with intense metastatic liposarcoma. (molecularcircuit.com)

79% younger than age 65 years) with liposarcoma and leiomyosarcoma were included. (shu.edu)
The most common (≥5%) Grade 3-4 laboratory abnormalities in liposarcoma and leiomyosarcoma were neutropenia, hypokalemia, and hypocalcemia. (drugs.com)
Inclusion criteria: * Histologically proven primary high risk leiomyosarcoma (LMS) or Liposarcoma (LPS) of retroperitoneal space or infra-peritoneal spaces of pelvis (LPS: Grade 3 DDLPS OR confirmed Grade 2 DDLPS on biopsy only if FNCLCC score = 5 AND clear necrosis on imaging. (who.int)
Primary high risk leiomyosarcoma or dedifferentiated liposarcoma of the retroperitoneum. (who.int)

We describe a case in which appropriate use of a variety of imaging modalities including testicular ultrasound and CT led to an important diagnosis of a large, well-differentiated liposarcoma in the right retroperitoneum of a patient with a right-sided groin mass. (harvard.edu)
Well-differentiated liposarcoma tends to occur in deep soft tissues of both the limbs and the retroperitoneum. (medscape.com)
Myxoid and/or round-cell liposarcomas and pleomorphic liposarcomas have a striking predilection for the limbs, and dedifferentiated liposarcoma occurs predominantly in the retroperitoneum. (medscape.com)

The diagnosis of well-differentiated retroperitoneal liposarcoma with renal involvement was made. (spandidos-publications.com)
In conclusion, retroperitoneal liposarcoma is a rare disease with a high rate of recurrence. (spandidos-publications.com)
The present study reported a case with retroperitoneal liposarcoma managed at Guihang Guiyang Hospital (Guiyang, China), and also performed a literature review on presentation, management and prognosis of this patient. (spandidos-publications.com)
The diagnosis was well-differentiated retroperitoneal liposarcoma. (spandidos-publications.com)
Hematoxylin and eosin staining of tissue shows that retroperitoneal well-differentiated liposarcoma, with negative margins, full of lipocytes. (spandidos-publications.com)

MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (qxmd.com)

Liposarcomas are the most common subtype of soft tissue sarcomas, accounting for at least 20% of all sarcomas in adults. (wikipedia.org)
The proposed study will be the first to describe the chromatin accessibility landscape of liposarcoma and to elucidate how differences in the noncoding genomes and complex chromosomal rearrangements between WDLPS and DDLPS histologies affect chromatin "openness," downstream gene regulatory networks, and ultimately disparate biologic subtype-specific behavior and prognosis. (curesarcoma.org)
We present a very rare case of an anterior mediastinal liposarcoma of the pleomorphic subtype in a 17-year-old girl, along with radiological and pathological correlation. (escholarship.org)
Although any liposarcoma subtype occasionally arises in the subcutis, involvement of the dermis appears to be exceedingly rare. (medscape.com)
A liposarcoma is a subtype of sarcoma, a rare and complex cancer usually diagnosed in adults between ages 40 and 60. (drallison.org)

Liposarcomas are the most common histologies of soft tissue sarcomas. (curesarcoma.org)
Similar to all soft-tissue sarcomas, round cell liposarcomas grow in the soft-tissues of the extremities and compromise or destroy the affected soft-tissue and muscles. (orthopediconcologist.com)
Overall, liposarcomas account for less than 20% of all soft tissue sarcomas, and the average patient age at presentation is 50 years. (medscape.com)
With an annual incidence of 2.5 cases per million population, liposarcoma is the most common soft tissue sarcoma, accounting for approximately 17% of all soft tissue sarcomas and 3% of all liposarcomas in the head and neck region (usually the neck and the cheek). (medscape.com)
Although liposarcomas account for about 17% of all soft tissue sarcomas, they are involved in only 4% of childhood soft tissue sarcomas. (medscape.com)
Sarcomas, including liposarcomas, requires diagnostic and treatment expertise often requiring sophisticated surgical techniques that only a knowledgeable orthopedic oncologist like Dr. Daniel Allison provides. (drallison.org)
Soft tissue sarcomas are rare cancers overall, but within the soft tissue category, liposarcoma ranks as the second most frequently diagnosed and tend to develop into a large soft tissue mass often with smaller tumors scattered around it. (drallison.org)
Liposarcomas (LPS), the most common soft tissue sarcomas accounting for less than 1% of all human cancer cases, display remarkable clinical and pathological heterogeneity. (biomedcentral.com)

Although the most common subtypes of liposarcoma, well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS), often coexist, their clinical behavior and prognosis differ dramatically. (curesarcoma.org)
Chromatin dysregulation of WDLPS and DDLPS may therefore play a critical role in sarcomagenesis and underly differences in the clinical behavior and aggressiveness between these common liposarcoma subtypes. (curesarcoma.org)
The above aims will be achieved by performing and integrating ATAC-seq and RNA-seq datasets using matched WDLPS and DDLPS tumors and normal fat acquired from 5 treatment naïve patients who underwent liposarcoma resection. (curesarcoma.org)
In order to identify and compare the genomic profiles, we analyzed array-based comparative genomic hybridization (array-CGH) profiles of 66 liposarcomas, including well-differentiated (WDLPS), dedifferentiated (DDLPS) and myxoid (MLPS) subtypes. (biomedcentral.com)
Morphologically, liposarcomas are divided into four main subtypes: well-differentiated (WDLPS), dedifferentiated (DDLPS), myxoid/round cell (MLPS/MRLPS) and pleomorphic liposarcomas (PLPS). (biomedcentral.com)

These and other distinct genetic aberrations may aid in the diagnosis of particular liposarcoma subtypes, and they can potentially be targets that can be exploited therapeutically. (medscape.com)
Eligibility Details: - Key Inclusion criteria - Age â‰¥18 and â‰¤ 75 years - Histologically or cytogenetically confirmed diagnosis of urothelial cancer, melanoma, ovarian cancer, esophageal , esophagogastric junction (EGJ) cancer, gastric cancer, non-small cell lung carcinoma (NSCLC), head and neck, synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) - Measurable disease according to RECIST v1.1 prior to leukapheresis and lymphodepletionHLA-A*02 positive. (participaid.co)
Cytologic testing may not differentiate between a liposarcoma and a lipoma, so a surgical biopsy is recommended for diagnosis. (ivis.org)
Rarity and heterogeneity of liposarcomas (LPS) make their diagnosis difficult even for sarcoma-experts pathologists. (biomedcentral.com)
Definite diagnosis of esophageal liposarcoma depends on histopathology, immunohistochemistry and molecular analysis . (bvsalud.org)

Round cell liposarcoma is the name given to the more aggressive form of myxoid liposarcoma. (mskcc.org)

We reviewed the cases of 50 patients with myxoid liposarcoma who were registered in the pathology files of the National Cancer Centre (NCC), Tokyo, Japan. (bmj.com)
Pathology revealed scrotal liposarcoma. (sls.org)

Further, medication ME0328 manufacture studies discovered the multi-targeted tyrosine kinase inhibitor, ponatinib being a powerful restorative agent effective against different subtypes of liposarcoma. (molecularcircuit.com)

Studies to date find that all five liposarcoma forms, while usually treatable at least initially by surgical resection, are often only marginally responsive to currently used chemotherapy and radiotherapy regimens. (wikipedia.org)
The liposarcomas require a wide range of further studies to determine their responsiveness to various radiotherapy, chemotherapy, and more novel treatment regimens as used individually and in various combinations that would include, where possible, surgical removal. (wikipedia.org)
Liposarcoma cell lines were used to determine the effects of PI3K targeted drug treatment with or without chemotherapy. (nih.gov)
Importantly, combination with PI-103 treatment strongly synergized the growth-inhibitory effects of the chemotherapy drugs doxorubicin and cisplatin in liposarcoma cells. (nih.gov)
Targeting the PI3K/AKT/pathway with small molecule inhibitors in combination with chemotherapy could be exploited as a novel strategy in the treatment of liposarcoma. (nih.gov)
Additionally, radiation and/or chemotherapy may be administered to treat round cell liposarcoma. (orthopediconcologist.com)
The U.S. Food and Drug Administration today approved Halaven (eribulin mesylate), a type of chemotherapy, for the treatment of liposarcoma (a specific type of soft tissue sarcoma) that cannot be removed by surgery (unresectable) or is advanced (metastatic). (blogspot.com)
The efficacy and safety of Halaven were evaluated in 143 clinical trial participants with advanced liposarcoma that was unresectable or had spread to nearby lymph nodes (locally advanced) or other parts of the body (metastatic), and who had been treated with chemotherapy. (blogspot.com)

Liposarcomas are generally large tumors (>10 cm) but can be of almost any size. (wikipedia.org)
Liposarcomas are malignant tumors of the lipocytes ( fat cells ) and are not commonly found in pet birds. (ivis.org)
These tumors included one highly differentiated liposarcoma with abnormal karyotype but no involvement of 12q13, seven lipomas with various cytogenetic aberrations of 12q13-15, two uterine leiomyomas with t(12;14) (q14-15;q23-24), and one hemangiopericytoma and one chondroma, both of which also had 12q13 changes. (lu.se)

Risk assessment in liposarcoma patients can be based on [(18)F]fluorodeoxyglucose (FDG) PET imaging. (medscape.com)
Personal experience in caring for myxoid liposarcoma patients, including the opportunity, unfortunately, to directly observe therapeutic failure, has been and continues to be a powerful motivation to pursue these research opportunities. (sarcomahelp.org)
The Initiative has funded four liposarcoma research grants totaling $600,000 and one study that included several types of sarcoma patients, including those with liposarcoma. (sarcomahelp.org)
The clinical and pathological features of 50 patients with myxoid liposarcoma were evaluated, and MIB-1 immunostaining was performed to grade these patients' tumours. (bmj.com)
Tumour grade determined by the grading system using the MIB-1 score (MIB-1 system) is a very strong prognostic factor in patients with myxoid liposarcoma. (bmj.com)
10- 12 However, to the best of our knowledge no detailed study of the prognostic significance of tumour grades assigned by a grading system in patients with myxoid liposarcoma has been published. (bmj.com)
The objective of our study was to determine the relation between clinical outcome and tumour grade defined by a MIB-1 score based grading system in patients with myxoid liposarcoma. (bmj.com)
Halaven (eribulin mesylate) was approved by the FDA for the treatment of patients with unresectable or advanced liposarcoma . (shu.edu)
Halaven is the first drug approved for patients with liposarcoma that has demonstrated an improvement in survival time," said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. (blogspot.com)
The median overall survival for patients with liposarcoma receiving Halaven was 15.6 months compared to 8.4 months for those who received dacarbazine. (blogspot.com)
The authors coordinated a first-in-kind Phase II clinical trial of the CDK4/6i abemaciclib for patients with progressive dedifferentiated liposarcoma with cellular studies interrogating the molecular basis of geroconversion. (stemcellsciencenews.com)
Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)

There are four main histological types: well differentiated, myxoid, pleomorphic, and round cell liposarcomas. (en-academic.com)

We studied a cohort of high-grade liposarcomas and benign lipomas across multiple disease sites, as well as two liposarcoma cell lines, using multiplexed mutational analysis. (nih.gov)
The development of a liposarcoma from a preexisting benign lipoma is rare. (medscape.com)

We were told two weeks ago, that the results of an extensive biopsy showed no sign of residual liposarcoma. (cancer.org)

Liposarcomas arise from the precursor lipoblasts of the adipocytes (i.e. fat cells) in adipose (i.e. fat) tissues. (wikipedia.org)

The patient received complete resection of the liposarcoma and the right kidney was preserved. (spandidos-publications.com)

One of the greatest challenges with liposarcoma, and other sarcoma subtypes, is the scope of subtypes, with each having separate characteristics and behavior. (drallison.org)

Well-differentiated liposarcoma has a tendency to regrow after initial treatment. (mskcc.org)
Without treatment, liposarcoma can metastasize or spread throughout the body, with the lungs, liver, and bones being the most common sites. (orthopediconcologist.com)
The treatment of round cell liposarcoma is very similar to the treatment of myxoid liposarcoma. (orthopediconcologist.com)

Round cell liposarcoma is a malignant sarcoma that has risks of recurrence and metastasis. (orthopediconcologist.com)

GOT-3 [20] (recurrence of the myxoid variant of the well-differentiated liposarcoma) and MLS-402 (myxoid liposarcoma) [16] had been generous presents from Dr. ?guy. (molecularcircuit.com)

7,14 Liposarcomas look similar to lipomas and are usually found near the keel bone or uropygial gland. (ivis.org)

Liposarcoma is a malignancy of fat cells (see Pediatric Liposarcoma and Liposarcoma Imaging ). (medscape.com)
Scrotal liposarcoma is a very rare scrotal malignancy that is a diagnostic and therapeutic challenge for the treating surgeon. (sls.org)
Liposarcoma is a malignancy of fat cells (see Liposarcoma in the Pediatric Medicine section and Liposarcoma, Soft Tissue in the Radiology section). (medscape.com)

The central soft-tissue component (asterisk) and thick, internal septations are consistent with liposarcoma. (medscape.com)
Liposarcoma is a type of cancer known as soft tissue sarcoma . (mskcc.org)
Liposarcoma is a soft-tissue sarcoma typically seen in adults. (escholarship.org)
Round Cell Liposarcoma is a malignant, or cancerous, soft-tissue sarcoma that most commonly occurs in the deep tissues of the thigh, or other extremities. (orthopediconcologist.com)
Round cell liposarcoma is a malignant (cancerous) and aggressive soft-tissue sarcoma. (orthopediconcologist.com)
Within the soft tissue category, liposarcoma is one of the more frequently diagnosed subtypes. (drallison.org)

Myxoid and round cell liposarcomas are regarded as belonging to a continuous histopathological spectrum characteristic of a chromosome translocation, t(12;16)(q13;p11), resulting in the fusion of the TLS and CHOP genes. (bmj.com)
Additionally, round cell liposarcomas appear similar to a myxoid liposarcoma with the exception that myxoid stroma is not present in round cell liposarcomas. (orthopediconcologist.com)
Round cell liposarcoma appears similar to a myxoid liposarcoma except that myxoid stroma is not present. (orthopediconcologist.com)
The work-up for round cell liposarcoma often consists of a physical examination, X-ray, MRI, CT, and bone scans. (orthopediconcologist.com)
The concept that round-cell liposarcoma represents the high-grade counterpart of myxoid liposarcoma is generally accepted. (medscape.com)

Pleomorphic liposarcoma is both uncommon and rarely occurs in the skin and subcutis. (medscape.com)
Liposarcoma is a specific type of STS that occurs in fat cells. (blogspot.com)

PI-103, a dual PI3K/mTOR inhibitor, effectively inhibited the activation of the PI3K/AKT in liposarcoma cell lines and induced apoptosis. (nih.gov)
A spindle-cell variant of well-differentiated liposarcoma is also described. (medscape.com)
Each one of these liposarcoma cell lines had been managed in RPMI moderate supplemented with fetal bovine serum inside a humidified incubator at 37?C with 5% CO2 [14]. (molecularcircuit.com)
Small-interfering RNA display Liposarcoma cell lines had been transfected having a siRNA kinase collection (including 94 kinase gene focus on) as explained previously [21]. (molecularcircuit.com)

Liposarcomas most frequently arise from the deep-seated stroma rather than the submucosal or subcutaneous fat. (medscape.com)

Histopathological evaluation of nonneoplastic nephrectomy specimens must be thoroughly considered, particularly in unusual circumstances such as RRL, where a preoperative erroneous initial impression of a malignant lesion such as angiomyolipoma or liposarcoma is possible. (who.int)

Another hallmark of the gene regulatory landscape is chromatin accessibility, which is regulated by epigenetic pathways and can be dysregulated as a result of both chromosomal rearrangements and mutations in the noncoding genome and which have been unstudied in liposarcoma. (curesarcoma.org)

Liposarcomas spread locally, and several may occur in the same area. (ivis.org)

Most liposarcomas have well-defined and mostly lobulated margins. (medscape.com)

A more aggressive form of well-differentiated liposarcoma is called d edifferentiated liposarcoma . (mskcc.org)

Well-differentiated liposarcoma is the most common form. (mskcc.org)
Myxoid liposarcoma is the second most common type of liposarcoma. (mskcc.org)
Liposarcomas are slightly more common in males than in females. (medscape.com)

Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify therapeutically-susceptible genetic alterations. (nih.gov)
The molecular mechanism underlying the development and progression of liposarcomas (LPS) remains only partially known. (biomedcentral.com)

Liposarcoma that resembles a skin tag has been reported but is an exceptionally rare event. (medscape.com)
Pleomorphic liposarcoma is extremely rare. (mskcc.org)
liposarcoma - n. a rare malignant tumour of fat cells. (en-academic.com)
Giant liposarcoma of esophagus: a rare case report. (bvsalud.org)
Objectif: Décrit pour la première fois en 1881 par Mynter1, l'abcès du psoas est une maladie rare. (bvsalud.org)

Pleomorphic Sclerotic Fibroma | Dermatology | Karger Publishers (karger.com)

Lipomas - Surgical Specialists of Greater NY (surgspecny.com)

Preexisting Immunity to CRISPR-Cas9: A Problem for Gene Editing in Cancer? - Cancer Therapy Advisor (cancertherapyadvisor.com)

Nathanael S. Gray's Profile | Stanford Profiles (profiles.stanford.edu)

Anatomy3

Diseases13

Chemicals and Drugs5

Phenomena and Processes2

A new rapid technique for the fixation of thyroid gland surgical specimens. (1/347)

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. (2/347)

Liposarcoma in association with total hip replacement. (3/347)

Prognostic relevance of p53 alterations and Mib-1 proliferation index in subgroups of primary liposarcomas. (4/347)

The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (5/347)

Influence of biologic factors and anatomic site in completely resected liposarcoma. (6/347)

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. (7/347)

Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. (8/347)

Liposarcoma

Liposarcoma, Myxoid

RNA-Binding Protein FUS

Retroperitoneal Neoplasms

Neoplasms, Adipose Tissue

Lipoma

Soft Tissue Neoplasms

Transcription Factor CHOP

Muscle Neoplasms

Spermatic Cord

Genital Neoplasms, Male

Sarcoma

Chromosomes, Human, Pair 12

Mesocolon

Dioxoles

Cell Dedifferentiation

Mediastinal Neoplasms

Tetrahydroisoquinolines

Leiomyosarcoma

Proto-Oncogene Proteins c-mdm2

Histiocytoma, Malignant Fibrous

Histiocytoma, Benign Fibrous

A new rapid technique for the fixation of thyroid gland surgical specimens. (1/347)

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. (2/347)

Liposarcoma in association with total hip replacement. (3/347)

Prognostic relevance of p53 alterations and Mib-1 proliferation index in subgroups of primary liposarcomas. (4/347)

The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (5/347)

Influence of biologic factors and anatomic site in completely resected liposarcoma. (6/347)

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. (7/347)

Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. (8/347)

Liposarcoma

Myxoid liposarcoma

List of OMIM disorder codes

Myxoid lipoblastoma

George Getzel Cohen

Leiomyoma

Lipoma

John Obafunwa

Undifferentiated pleomorphic sarcoma

Sarcoma

Trabectedin

Margaret Ransone Murray

Politics of Toronto

Rob Ford

Not My Time (song)

STAT6

Timeline of Rob Ford video scandal

DNA damage-inducible transcript 3

Ectomesenchymoma

Andrea Hayes-Jordan

Charlie Davies

Deaths in July 2014

Eribulin

Small supernumerary marker chromosome

Deaths in March 2016

RNA-binding protein FUS

The Wendy Walk

Deaths in April 2016

Mark Strand

Abemaciclib

Liposarcoma - Wikipedia

Pediatric Liposarcoma Medication

Liposarcoma Differential Diagnoses

Liposarcoma: new entities and evolving concepts

liposarcoma - Cancer Survivors Network

Liposarcoma Cancer: Diagnosis, Treatment, Support & Research

Newly found liposarcoma please help - Cancer Survivors Network

Translational Research in Well-Differentiated and Dedifferentiated Liposarcoma

Vesalius Clinical Folios: Open Biopsy for Suspected Liposarcoma

Mediastinal Pleomorphic Liposarcoma Diagnosed by Fine Needle Aspiration Biopsy | Acta Cytologica | Karger Publishers

Pathology⎪Liposarcoma by The Orthobullets Podcast

Pathology in practice. Liposarcoma - PubMed

Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma - PubMed

Establishment and evaluation of retroperitoneal liposarcoma patient-derived xenograft models: an ideal model for preclinical...

Lipoma and Liposarcoma | Radsource

Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience [Abstract]

Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma | Archives of...

Pegylated liposomal doxorubicin-induced renal toxicity in retroperitoneal liposarcoma: a case report and literature review<...

View of SPECTRUM OF LIPOSARCOMAS-A STUDY OF 106 CASES

Halaven (eribulin mesylate) for the Treatment of Advanced Liposarcoma - Clinical Trials Arena