Lipoprotein Lipase
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.
Lipase
Lipoproteins
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Lipoproteins, VLDL
A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.
Lipoproteins, HDL
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
Hyperlipoproteinemia Type I
Apolipoprotein C-II
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.
Lipoprotein(a)
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Chylomicrons
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Apolipoproteins C
A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.
Apolipoproteins
Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.
Receptors, Lipoprotein
Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
Lipolysis
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Cholesterol
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Apolipoproteins B
Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.
Receptors, LDL
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Cholesterol, HDL
Lipoproteins, IDL
A mixture of very-low-density lipoproteins (VLDL), particularly the triglyceride-poor VLDL, with slow diffuse electrophoretic mobilities in the beta and alpha2 regions which are similar to that of beta-lipoproteins (LDL) or alpha-lipoproteins (HDL). They can be intermediate (remnant) lipoproteins in the de-lipidation process, or remnants of mutant CHYLOMICRONS and VERY-LOW-DENSITY LIPOPROTEINS which cannot be metabolized completely as seen in FAMILIAL DYSBETALIPOPROTEINEMIA.
Lipoprotein Lipase Activators
Liver
Apolipoproteins E
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Lipid Metabolism
Lipoproteins, HDL2
Lipoproteins, HDL3
Cholesterol Esters
Hyperlipoproteinemias
Sterol Esterase
Angiopoietins
Low Density Lipoprotein Receptor-Related Protein-1
Cholesterol, LDL
Monoacylglycerol Lipases
Apolipoprotein C-III
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).
Apolipoproteins A
Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.
Milk
Fatty Acids, Nonesterified
Cholesterol, VLDL
Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL.
Dietary Fats
Apolipoprotein B-100
Heparin Lyase
An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 4.2.2.7.
Fatty Acids
Arteriosclerosis
Hyperlipoproteinemia Type IV
A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Emulsions
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Hyperlipidemia, Familial Combined
Apolipoprotein A-II
The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.
Cells, Cultured
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Apolipoprotein B-48
A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.
Cattle
Cholesterol Ester Transfer Proteins
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Colipases
Ultracentrifugation
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Hypercholesterolemia
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Carrier Proteins
Base Sequence
Adipocytes
Amino Acid Sequence
Lipid Mobilization
LIPOLYSIS of stored LIPIDS in the ADIPOSE TISSUE to release FREE FATTY ACIDS. Mobilization of stored lipids is under the regulation of lipolytic signals (CATECHOLAMINES) or anti-lipolytic signals (INSULIN) via their actions on the hormone-sensitive LIPASE. This concept does not include lipid transport.
Hyperlipoproteinemia Type III
An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.
Phosphatidylcholine-Sterol O-Acyltransferase
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
Myocardium
Hyperlipoproteinemia Type V
A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .
Rats, Inbred Strains
Esterification
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
Polysaccharide-Lyases
Hyperlipoproteinemia Type II
Hypolipidemic Agents
Protein Binding
Heterozygote
Apolipoprotein E2
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Adipose Tissue, Brown
Oleic Acid
Body Weight
Mutation
Electrophoresis, Polyacrylamide Gel
Oleic Acids
Chromatography, Affinity
Biological Transport
LDL-Receptor Related Protein-Associated Protein
Pancreas
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Deoxyribonuclease HindIII
Cricetinae
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Atherosclerosis
Heparan Sulfate Proteoglycans
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
Binding Sites
Carboxylic Ester Hydrolases
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Apoproteins
Chromatography, Agarose
alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Scavenger Receptors, Class B
Hypolipoproteinemias
Protamines
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Heparitin Sulfate
CHO Cells
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Receptors, Immunologic
Gene Expression Regulation, Enzymologic
Apolipoprotein C-I
A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.
Rabbits
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Glycoproteins
Genotype
Glycerol
Reference Values
Apolipoprotein E3
A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.
Gene Expression
Enzyme Activation
Receptors, Scavenger
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
Mice, Transgenic
Structure-Activity Relationship
Rhizopus
Phosphatidylcholines
Apoprotein(a)
A large and highly glycosylated protein constituent of LIPOPROTEIN (A). It has very little affinity for lipids but forms disulfide-linkage to APOLIPOPROTEIN B-100. Apoprotein(a) has SERINE PROTEINASE activity and can be of varying sizes from 400- to 800-kDa. It is homologous to PLASMINOGEN and is known to modulate THROMBOSIS and FIBRINOLYSIS.
Dyslipidemias
Lactones
Blotting, Northern
Chromatography, Gel
Phospholipid Transfer Proteins
Coronary Disease
LDL-Receptor Related Proteins
Sterol O-Acyltransferase
Lipid Metabolism, Inborn Errors
Geotrichum
Iodine Radioisotopes
Transfection
Hydroxymethylglutaryl CoA Reductases
Muscle, Skeletal
Electrophoresis, Agar Gel
Insulin Resistance
Gene Expression Regulation
Rats, Sprague-Dawley
Caloric restriction leads to regional specialisation of adipocyte function in the rat. (1/1971)
The study analysed the responses of three metabolic parameters in five distinct adipose tissue depots to caloric restriction (4 weeks) in the rat. The aims were to evaluate whether specific adipose tissue depots were recruited for triacylglycerol (TAG) storage and/or mobilisation, and to determine to what extent specific adipose tissue depots exhibited preferences for the source of fatty acid (FA) for TAG storage. Caloric restriction led to a general enhancement of the response of lipoprotein lipase (LPL), FA synthesis and glucose utilisation to a meal. Effects were particularly marked in the parametrial, perirenal and interscapular depots compared with mesenteric and subcutaneous depots. There was no evidence that individual depots selectively expressed a preference for the pathways concerned with the generation of FA for storage (the exogenous (LPL) and the endogenous (synthesis) pathway). However, the temporal sequence of activation of these pathways differed in a manner consistent with a switch from preponderant use of FA produced via de novo synthesis during the very early phase of feeding towards later use of FA derived from circulating TAG. The overall excursions in insulin levels observed in the calorie-restricted rats were comparable to those found in free-feeding rats, but the magnitude and the rapidity of the individual metabolic responses of the adipocyte were augmented. The data are consistent with a general enhancement of insulin sensitivity and responsiveness in adipose tissue of calorie-restricted rats, together with adaptive regional specialisation of adipocyte function. These adaptations would be predicted to facilitate the immediate conservation of dietary nutrients by promoting their storage as the FA or glycerol moieties of adipose tissue TAG and thereby to ensure the regulated release of FA and glycerol from adipose tissue in accordance with the requirement for glucose conservation and/or production. (+info)Binding of beta-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas ApoE only modulates binding affinity. (2/1971)
The binding of beta-VLDL to heparan sulfate proteoglycans (HSPG) has been reported to be stimulated by both apoE and lipoprotein lipase (LPL). In the present study we investigated the effect of the isoform and the amount of apoE per particle, as well as the role of LPL on the binding of beta-VLDL to HSPG. Therefore, we isolated beta-VLDL from transgenic mice, expressing either APOE*2(Arg158-->Cys) or APOE*3-Leiden (E2-VLDL and E3Leiden-VLDL, respectively), as well as from apoE-deficient mice containing no apoE at all (Enull-VLDL). In the absence of LPL, the binding affinity and maximal binding capacity of all beta-VLDL samples for HSPG-coated microtiter plates was very low. Addition of LPL to this cell-free system resulted in a 12- to 55-fold increase in the binding affinity and a 7- to 15-fold increase in the maximal binding capacity (Bmax). In the presence of LPL, the association constant (Ka) tended to increase in the order Enull-VLDLInduced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels. (3/1971)
The tissue-specific expression of lipoprotein lipase (LPL) in adipose tissue (AT), skeletal muscle (SM), and cardiac muscle (CM) is rate-limiting for the uptake of triglyceride (TG)-derived free fatty acids and decisive in the regulation of energy balance and lipoprotein metabolism. To investigate the tissue-specific metabolic effects of LPL, three independent transgenic mouse lines were established that expressed a human LPL (hLPL) minigene predominantly in CM. Through cross-breeding with heterozygous LPL knockout mice, animals were generated that produced hLPL mRNA and enzyme activity in CM but lacked the enzyme in SM and AT because of the absence of the endogenous mouse LPL gene (L0-hLPL). LPL activity in CM and postheparin plasma of L0-hLPL mice was reduced by 34% and 60%, respectively, compared with control mice. This reduced LPL expression was sufficient to rescue LPL knockout mice from neonatal death. L0-hLPL animals developed normally with regard to body weight and body-mass composition. Plasma TG levels in L0-hLPL animals were increased up to 10-fold during the suckling period but normalized after weaning and decreased in adult animals. L0-hLPL mice had normal plasma high-density lipoprotein (HDL)-cholesterol levels, indicating that LPL expression in CM alone was sufficient to allow for normal HDL production. The absence of LPL in SM and AT did not cause detectable morphological or histopathological changes in these tissues. However, the lipid composition in AT and SM exhibited a marked decrease in polyunsaturated fatty acids. From this genetic model of LPL deficiency in SM and AT, it can be concluded that CM-specific LPL expression is a major determinant in the regulation of plasma TG and HDL-cholesterol levels. (+info)Response of adipose tissue lipoprotein lipase to the cephalic phase of insulin secretion. (4/1971)
Modulation of lipoprotein lipase (LPL) allows a tissue-specific partitioning of triglyceride-derived fatty acids, and insulin is a major modulator of its activity. The present studies were aimed to assess in rats the contribution of insulin to the response of adipose tissue and muscle LPL to food intake. Epididymal and retroperitoneal adipose LPL rose 65% above fasting values as early as 1 h after the onset of a 30-min high-carbohydrate meal, with a second activity peak 1 h later that was maintained for an additional 2 h. Soleus muscle LPL was decreased by 25% between 0.5 and 4 h after meal intake. The essential contribution of insulin to the LPL response to food intake was determined by preventing the full insulin response to meal intake by administration of diazoxide (150 mg/kg body wt, in the meal). The usual postprandial changes in adipose and muscle LPL did not occur in the absence of an increase in insulinemia. However, the early (60 min) increase in adipose tissue LPL was not prevented by the drug, likely because of the maintenance of the early centrally mediated phase of insulin secretion. In a subsequent study, rats chronically implanted with a gastric cannula were used to demonstrate that the postprandial rise in adipose LPL is independent of nutrient absorption and can be elicited by the cephalic (preabsorptive) phase of insulin secretion. Obese Zucker rats were used because of their strong cephalic insulin response. After an 8-h fast, rats were fed a liquid diet ad libitum (orally, cannula closed), sham fed (orally, cannula opened), or fed directly into the stomach via the cannula during 4 h. Insulinemia increased 10-fold over fasting levels in ad libitum- and intragastric-fed rats and threefold in sham-fed rats. Changes in adipose tissue LPL were proportional to the elevation in plasma insulin levels, demonstrating that the cephalic-mediated rise in insulinemia, in the absence of nutrient absorption, stimulates adipose LPL. These results demonstrate the central role of insulin in the postprandial response of tissue LPL, and they show that cephalically mediated insulin secretion is able to stimulate adipose LPL. (+info)Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. (5/1971)
Lipoprotein lipase and the receptor-associated protein (RAP) bind to overlapping sites on the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP). We have investigated if lipoprotein lipase interacts with the RAP binding but structurally distinct receptor sortilin/neurotensin receptor-3. We show, by chemical cross-linking and surface plasmon resonance analysis, that soluble sortilin binds lipoprotein lipase with an affinity similar to that of LRP. The binding was inhibited by heparin and RAP and by the newly discovered sortilin ligand neurotensin. In 35S-labeled 3T3-L1 adipocytes treated with the cross-linker dithiobis(succinimidyl propionate), lipoprotein lipase-containing complexes were isolated by anti-sortilin antibodies. To elucidate function in cells, sortilin-negative Chinese hamster ovary cells were transfected with full-length sortilin and shown to express about 8% of the receptors on the cell surface. These cells degraded 125I-labeled lipoprotein lipase much faster than the wild-type cells. The degradation was inhibited by unlabeled lipoprotein lipase, indicating a saturable pathway, and by RAP and heparin. Moreover, inhibition by the weak base chloroquine suggested that degradation occurs in an acidic vesicle compartment. The results demonstrate that sortilin is a multifunctional receptor that binds lipoprotein lipase and, when expressed on the cell surface, mediates its endocytosis and degradation. (+info)Role of protein kinase C in the translational regulation of lipoprotein lipase in adipocytes. (6/1971)
The hypertriglyceridemia of diabetes is accompanied by decreased lipoprotein lipase (LPL) activity in adipocytes. Although the mechanism for decreased LPL is not known, elevated glucose is known to increase diacylglycerol, which activates protein kinase C (PKC). To determine whether PKC is involved in the regulation of LPL, we studied the effect of 12-O-tetradecanoyl phorbol 13-acetate (TPA) on adipocytes. LPL activity was inhibited when TPA was added to cultures of 3T3-F442A and rat primary adipocytes. The inhibitory effect of TPA on LPL activity was observed after 6 h of treatment, and was observed at a concentration of 6 nM. 100 nM TPA yielded maximal (80%) inhibition of LPL. No stimulation of LPL occurred after short term addition of TPA to cultures. To determine whether TPA treatment of adipocytes decreased LPL synthesis, cells were labeled with [35S]methionine and LPL protein was immunoprecipitated. LPL synthetic rate decreased after 6 h of TPA treatment. Western blot analysis of cell lysates indicated a decrease in LPL mass after TPA treatment. Despite this decrease in LPL synthesis, there was no change in LPL mRNA in the TPA-treated cells. Long term treatment of cells with TPA is known to down-regulate PKC. To assess the involvement of the different PKC isoforms, Western blotting was performed. TPA treatment of 3T3-F442A adipocytes decreased PKC alpha, beta, delta, and epsilon isoforms, whereas PKC lambda, theta, zeta, micro, iota, and gamma remained unchanged or decreased minimally. To directly assess the effect of PKC inhibition, PKC inhibitors (calphostin C and staurosporine) were added to cultures. The PKC inhibitors inhibited LPL activity rapidly (within 60 min). Thus, activation of PKC did not increase LPL, but inhibition of PKC resulted in decreased LPL synthesis by inhibition of translation, indicating a constitutive role of PKC in LPL gene expression. (+info)Association of lipoprotein lipase gene polymorphisms with coronary artery disease. (7/1971)
OBJECTIVES: The purpose of this study was to test whether the HindIII (+) and PvuII (-) or (+) restriction enzyme-defined alleles are associated with angiographic coronary artery disease (CAD). BACKGROUND: Lipoprotein lipase (LPL) plays a central role in lipid metabolism, hydrolyzing triglyceride in chylomicrons and very low density lipoproteins. Polymorphic variants of the LPL gene are common and might affect risk of CAD. METHODS: Blood was drawn from 725 patients undergoing coronary angiography. Leukocyte deoxyribonucleic acid segments containing the genomic sites were amplified by the polymerase chain reaction and digested, and polymorphisms were identified after electrophoresis in 1.5% agarose gel. RESULTS: In no-CAD control subjects (n = 168), HindIII (-) and (+) allelic frequencies were 28.6% and 71.4%, and (-) and (+) alleles were carried by 44.0% and 86.9% of subjects, respectively. Control PvuII (-) and (+) allelic frequencies were 41.7% and 58.3%, and (-) and (+) alleles were carried by 64.3% and 81.0%, respectively. In CAD patients (>60% stenosis; n = 483), HindIII (+) allelic carriage was increased (93.8% of patients, odds ratio [OR] = 2.28, confidence interval [CI] 1.27 to 4.00). Also, PvuII (-) allelic carriage tended to be more frequent in CAD patients (OR = 1.33, CI 0.92 to 1.93). Adjusted for six CAD risk factors and the other polymorphism, HindIII (+) carriage was associated with an OR = 2.86, CI 1.50 to 5.42, p = 0.0014, and PvulI (-) carriage, OR = 1.42, CI 0.95 to 2.12, p = 0.09. The two polymorphisms were in strong linkage disequilibrium, and a haplotype association was suggested. CONCLUSIONS: The common LPL polymorphic allele, HindIII (+), is moderately associated with CAD, and the PvuII (-) allele is modestly associated (trend). Genetic variants of LPL deserve further evaluation as risk factors for CAD. (+info)Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. (8/1971)
Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparin LPL (PH-LPL) activity and lipids and lipoproteins in a large, well-defined cohort of Dutch males with coronary artery disease (CAD). These subjects were drawn from the REGRESS study, totaled 730 in number and were evaluated against 75 healthy, normolipidemic male controls. Fasting mean PH-LPL activity in the CAD subjects was 108 46 mU/ml, compared to 138 44 mU/ml in controls (P < 0.0001). When these patients were divided into activity quartiles, those in the lowest versus the highest quartile had higher levels of TG (P < 0.001), VLDLc and VLDL-TG (P = 0.001). Conversely, levels of TC, LDL, and HDLc were lower in these patients (P = 0.001, P = 0.02, and P = 0.001, respectively). Also, in this cohort PH-LPL relationships with lipids and lipoproteins were not altered by apoE genotypes. The frequency of common mutations in the LPL gene associated with partial LPL deficiency (N291S and D9N carriers) in the lowest quartile for LPL activity was more than double the frequency in the highest quartile (12.0% vs. 5.0%; P = 0.006). By contrast, the frequency of the S447X LPL variant rose from 11.5% in the lowest to 18.3% (P = 0.006) in the highest quartile. This study, in a large cohort of CAD patients, has shown that PH-LPL activity is decreased (22%; P = 0.001) when compared to controls; that the D9N and N291S, and S447X LPL variants are genetic determinants, respectively, in CAD patients of low and high LPL PH-LPL activities; and that PH-LPL activity is strongly associated with changes in lipids and lipoproteins. (+info)
Association of Backfat Thickness with Postheparin Lipoprotein Lipase Activity and Very Low Density Lipoprotein-Subfractions in...
Gastric Inhibitory Polypeptide Enhanced Lipoprotein Lipase Activity in Cultured Preadipocytes | Diabetes
Inhibition of lipoprotein lipase activity by high density lipoprotein & apolipoproteins C, E & A in rhesus monkeys. - Semantic...
Effects of a Six Month Training Program on Serum Lipids, Glucose, Insulin and Adipose Tissue Lipoprotein Lipase in Young...
Intra- and extracellular forms of lipoprotein lipase in adipose tissue
Lipoprotein Lipase Mass and Activity in Plasma and Their Increase After Heparin Are Separate Parameters With Different...
Further Observations on the Activation and Inhibition of Lipoprotein Lipase by Apolipoproteins | Circulation Research
Clearing-factor lipase in adipose tissue. Distinction of different states of the enzyme and the possible role of the fat cell...
Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for...
Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia - Full Text View - ClinicalTrials.gov
Differential effects of lipoprotein lipase on tumor necrosis factor-α and interferon-γ-mediated gene expression in human...
Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site
JCI -
Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low...
A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron...
Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation...
Lipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise | Lipids in Health and...
Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level. - PubMed -...
Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient...
The characterization of lipoprotein lipase isolated from the post-heparin plasma of the rainbow trout, Salmo gairdneri...
Free fatty acids: the possible regulators of muscle lipoprotein lipase | Biochemical Society Transactions
Hepatic regeneration induces changes in lipoprotein lipase activity in several tissues and its re-expression in the liver |...
Intravascular Free Tissue Factor Pathway Inhibitor Is Inversely Correlated With HDL Cholesterol and Postheparin Lipoprotein...
Plus it
Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats
Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury
Hippocampal lipoprotein lipase regulates energy balance in rodents<...
Lipoprotein Lipase Important for Fat Burning | androseries
Search Results | Biochemical Journal | Portland Press
Influence of PvuII (Intron 6) polymorphism of the lipoprotein lipase gene on cord plasma lipid and apolipoprotein levels in...
Adipose Tissue, Brown | The Chopra Library
Relative LPL expression of Group C compared to B. Fold | Open-i
Advice | Josh Bezoni | Fitness
Immunity Archives - Perfect Health Diet | Perfect Health Diet
CiNii 論文 -
Chylomicronemia Caused by Lipoprotein Lipase Gene Mutation Related to a Hyper...
Lpl ELISA Kit| Rat Lipoprotein lipase ELISA Kit [EF017174] - $566.00 : Plasmid,ELISA Kits,antibodies,strains, - Nova lifetech...
Association between lipoprotein lipase (LPL) gene and blood lipids: A common variant for a common trait? - Morabia - 2003 -...
A Common Mutation in the Lipoprotein Lipase Gene (N291S) Alters the Lipoprotein Phenotype and Risk for Cardiovascular Disease...
PRIME PubMed | Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and...
Search Results | Journal of Experimental Medicine | Rockefeller University Press
Lipoprotein Lipase/LPL Antibody Pair (H00004023-PW1): Novus Biologicals
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin | Semantic Scholar
Lipoprotein Lipase & Insulin | Healthy Eating | SF Gate
重组人Lipoprotein lipase (ab115500)| Abcam中国
Suchergebnis: Picard, F.
Nerdy FCS | Nerdy Nate
Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4...
Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency<...
Action of Lipoprotein Lipase on Phospholipid Monolayers. Activation by Apolipoprotein C-II<...
LPL | SelfDecode | Genome Analysis
Familial lipoprotein lipase deficiency - Broadview Heights Family Medicine, Inc.
Lipoprotein lipase deficiency - Wikipedia
Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
北京大学医学部机构知识库([email protected]): Comparative Analyses of Lipoprotein Lipase, Hepatic Lipase, and Endothelial Lipase, and Their Binding...
Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity
Familial lipoprotein lipase inhibitor: Definition with Familial lipoprotein lipase inhibitor Pictures and Photos
Effects of insulin and fetal bovine serum on lipoprotein lipase and glucose and acetate utilizations by cultured bovine adipose...
Association between skeletal muscle mass and serum concentrations of lipoprotein lipase, GPIHBP1, and hepatic triglyceride...
Lipoprotein lipase - Wikipedia
Familial Lipoprotein Lipase Deficiency - Clinical Advisor
The gut microbiota as an environmental factor that regulates fat storage | PNAS
Plus it
Volanesorsen Active Not Recruiting Phase 3 Trials for Lipoprotein Lipase Deficiency / Hyperlipoproteinemia Type 1 / Familial...
Recent Articles | Lipoprotein Lipase Deficiency, Genetics & Genomics And Ecology | The Scientist Magazine®| Page 34
Recent Articles | Lipoprotein Lipase Deficiency, Evolution And Microbiology | The Scientist Magazine®
List of OMIM disorder codes
ECM1 Lipoprotein glomerulopathy; 611771; APOE Lipoprotein lipase deficiency; 238600; LPL Lissencephaly 3; 611603; TUBA1A ... TP63 Lipase deficiency, combined; 246650; LMF1 Lipodystrophy, congenital generalized, type 1; 608594; AGPAT2 Lipodystrophy, ...
Ibrolipim
... (NO-1886) is a cholesterol lowering drug from the statin family, which acts as a lipoprotein lipase activator. The ... Yin W, Tsutsumi K (2003). "Lipoprotein lipase activator NO-1886". Cardiovascular Drug Reviews. 21 (2): 133-42. doi:10.1111/j. ...
Apolipoprotein C-III
APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to inhibit hepatic uptake of triglyceride-rich particles. ... "Metabolism of very-low-density lipoprotein and low-density lipoprotein containing apolipoprotein C-III and not other small ... Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as ... "A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein ...
Omega-3 acid ethyl esters
... and increased activity of lipoprotein lipase in blood. The synthesis of triglycerides is reduced in the liver as EPA and DHA ... and to enhance clearance of triglycerides from circulating very low-density lipoprotein (VLDL) particles; the way it does that ...
GPIHBP1
The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly ... "GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4". The Journal ... That Cannot Bind Lipoprotein Lipase". Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (6): 956-962. doi:10.1161/ATVBAHA. ... "The Acidic Domain of GPIHBP1 is Important for the Binding of Lipoprotein Lipase and Chylomicrons". Journal of Biological ...
Omega-3 carboxylic acids
... and increased activity of lipoprotein lipase in blood. Omega-3 carboxylic acids are derived from fish oil and are a purified ... and to enhance clearance of triglycerides from circulating very low-density lipoprotein (VLDL) particles; the way it does that ... carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein ...
Ethyl eicosapentaenoic acid
... and increased activity of lipoprotein lipase in blood. Ethyl eicosapentaenoic acid (E-EPA) is an ethyl ester of ... and to enhance clearance of triglycerides from circulating very low-density lipoprotein (VLDL) particles; the way it does that ... DHA alone appears to raise low-density lipoprotein (the variant which drives atherosclerosis; sometimes very inaccurately ...
Chylomicron
... where their triglyceride components are hydrolyzed by the activity of the lipoprotein lipase, allowing the released free fatty ... APOC2 is the coenzyme for lipoprotein lipase (LPL) activity. Once triglyceride stores are distributed, the chylomicron returns ... also known as ultra low-density lipoproteins (ULDL), are lipoprotein particles that consist of triglycerides (85-92%), ... ULDLs, if in the region of 1,000 nm or more, are the only lipoprotein particles that can be seen using a light microscope, at ...
Exoenzyme
Lipoprotein lipase (LPL) is a type of digestive enzyme that helps regulate the uptake of triacylglycerols from chylomicrons and ... Lipoprotein lipase is downregulated by high levels of insulin, and upregulated by high levels of glucagon and adrenaline. ... Lipase assays are done using a lipid agar with a spirit blue dye. If the bacteria has lipase, a clear streak will form in the ... Kiens B, Lithell H, Mikines KJ, Richter EA (October 1989). "Effects of insulin and exercise on muscle lipoprotein lipase ...
ANGPTL8
It shares with ANGPTL4 and ANGPTL8 the ability to inhibit the enzyme Lipoprotein lipase (LPL), and its hepatic overexpression ... with its interacting partner lipoprotein lipase". Computational Biology and Chemistry. 61: 210-20. doi:10.1016/j.compbiolchem. ... antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase". ... mice lacking ANGPTL8 exhibit markedly decreased uptake of Very low-density lipoprotein-derived fatty acids into white adipose ...
Sortilin 1
Other processes involving sortilin include endocytosis, negative regulation of lipoprotein lipase activity, myotube ... "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase". The Journal of Biological Chemistry. 274 ... "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase". The Journal of Biological Chemistry. 274 ... Strong A, Rader DJ (June 2012). "Sortilin as a regulator of lipoprotein metabolism". Current Atherosclerosis Reports. 14 (3): ...
Claire Weekes
"Placental lipoprotein lipase (LPL) gene expression in a placentotrophic lizard, Pseudemoia entrecasteauxii". Journal of ...
Placentation
Griffith, O. W., Ujvari, B., Belov, K., & Thompson, M. B. (2013). Placental lipoprotein lipase (LPL) gene expression in a ... Griffith, OW; Ujvari, B; Belov, K; Thompson, MB (2013). "Placental lipoprotein lipase (LPL) gene expression in a ...
Pseudemoia entrecasteauxii
Griffith, OW; Ujvari, B; Belov, K; Thompson, MB (2013). "Placental lipoprotein lipase (LPL) gene expression in a ... most likely occurs through the yolk sac placenta and is facilitated in part by the production of the protein lipoprotein lipase ...
Gene therapy
Glybera treats one such disease, caused by a defect in lipoprotein lipase. DNA must be administered, reach the damaged cells, ... In 2012 Glybera, a treatment for a rare inherited disorder, lipoprotein lipase deficiency became the first treatment to be ... The treatment used Alipogene tiparvovec (Glybera) to compensate for lipoprotein lipase deficiency, which can cause severe ...
Carbonyl cyanide m-chlorophenyl hydrazone
... on the dimerization of lipoprotein lipase". Biochimica et Biophysica Acta. 1344 (2): 132-8. doi:10.1016/s0005-2760(96)00146-4. ...
ANGPTL4
"Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue". ... Lafferty MJ, Bradford KC, Erie DA, Neher SB (October 2013). "Angiopoietin-like protein 4 inhibition of lipoprotein lipase: ... causing elevation of serum TG levels via inhibition of the enzyme lipoprotein lipase (LPL). Biochemical studies indicate that ...
Alipogene tiparvovec
"Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase-Deficient Patients". ... The adeno-associated virus serotype 1 (AAV1) viral vector delivers an intact copy of the human lipoprotein lipase (LPL) gene to ... Alipogene tiparvovec, sold under the brand name Glybera, is a gene therapy treatment designed to reverse lipoprotein lipase ... Scott, Lesley J. (2015). "Alipogene Tiparvovec: A Review of Its Use in Adults with Familial Lipoprotein Lipase Deficiency". ...
Robert H. Eckel
He has done significant research in the biology and pathophysiology of lipoprotein lipase. Eckel was on the Scientific Advisory ...
Gemfibrozil
... increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride ... This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are ... levels Modest reduction of low density lipoprotein (LDL) levels Moderate increase in high density lipoprotein (HDL) levels GI ... several theories exist regarding the very low density lipoprotein (VLDL) effect; it can inhibit lipolysis and decrease ...
David J. Galton
Thus one extra sialyl residue on apolipoprotein C3 impairs its action on lipoprotein lipase. This can affect expression of the ... Stocks, J; Holdsworth, G; Galton, DJ (1982). "An abnormal triglyceride-rich lipoprotein containing excess sialylated ... Stocks, J; Holdsworth, G; Galton, DJ (1979). "Hypertriglyceridaemia associated with an abnormal triglyceride-rich lipoprotein ...
Familial hypertriglyceridemia
Inactivity of lipoprotein lipase (LPL) plays the predominant role in the development of familial hypertriglyceridemia. LPL ... Individuals with the disorder are mostly heterozygous in an inactivating mutation of the gene encoding for lipoprotein lipase ( ... 2019). "Characterization of lipoprotein profiles in patients with hypertriglyceridemic Fredrickson-Levy and Lees dyslipidemia ... is a genetic disorder characterized by the liver overproducing very-low-density lipoproteins (VLDL). As a result, an afflicted ...
Angiostrongylus cantonensis
The role of lipoproteins, lipases and thyroid hormones in coronary lesion growth". Atherosclerosis. 68 (1-2): 51-8. doi:10.1016 ...
Cuilin Zhang
Zhang, Cuilin (2003). Variants in the Lipoprotein Lipase Gene and Paraoxonase Gene and Risk of Preeclampsia (Ph.D. thesis). ... Zhang's dissertation was titled Variants in the Lipoprotein Lipase Gene and Paraoxonase Gene and Risk of Preeclampsia. Her ...
POU2F1
Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter". J. Biol. Chem ...
LRP2
... binds lipoprotein lipase in vitro". J. Biol. Chem. 268 (19): 14176-81. PMID 7686151. Kounnas MZ, Loukinova EB, Stefansson S, ... Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 ... LRP2/megalin is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR). ... "Entrez Gene: LRP2 low density lipoprotein-related protein 2". Korenberg JR, Argraves KM, Chen XN, Tran H, Strickland DK, ...
GPIHBP1 - ويكيبيديا
regulation of lipoprotein lipase activity. • intracellular protein transport. • protein import. • protein localization to cell ... positive regulation of lipoprotein lipase activity. • triglyceride homeostasis. • positive regulation of chylomicron remnant ... an endothelial cell transporter for lipoprotein lipase". The Journal of Lipid Research. 52 (11): 1869-1884. doi:10.1194/jlr. ... "GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4". The Journal ...
Hemophagocytic lymphohistiocytosis
TNF-alpha and TNF-gamma may also lead to inhibition of lipoprotein lipase or stimulate triglyceride synthesis. Activated ...
Leukemia inhibitory factor
Mori M, Yamaguchi K, Abe K (May 1989). "Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell ...
Starvation
"Relationship of organ lipoprotein lipase activity and ketonuria to hypertriglyceridemia in starved and streptozocin-induced ...
肥胖症 - 维基百科,自由的百科全书
脂蛋白脂酶缺乏症/Ia型(英语:Lipoprotein lipase deficiency) ...
Familial hypercholesterolemia
Lipoprotein lipase deficiency. *Familial apoprotein CII deficiency. ReferencesEdit. *^ Goldberg, AC; Hopkins, PN; Toth, PP; ... markedly raised level of low-density lipoprotein (LDL), normal level of high-density lipoprotein (HDL), and normal level of ... Apolipoprotein B, in its ApoB100 form, is the main apolipoprotein, or protein part of the lipoprotein particle. Its gene is ... Several studies found that a high level of lipoprotein(a) was an additional risk factor for ischemic heart disease.[19][20] The ...
Human digestive system
Gastric lipase secreted by the chief cells in the fundic glands in the gastric mucosa of the stomach, is an acidic lipase, in ... The liver synthesises the bulk of lipoproteins. The liver is located in the upper right quadrant of the abdomen and below the ... Lipase starts to work on breaking down fats. Lipase is further produced in the pancreas where it is released to continue this ... The presence of salivary lipase is of prime importance in young babies whose pancreatic lipase has yet to be developed.[14] ...
Angiostrongylus cantonensis
The role of lipoproteins, lipases and thyroid hormones in coronary lesion growth". Atherosclerosis. 68 (1-2): 51-8. doi:10.1016 ...
Retina
Lipemia retinalis is a white appearance of the retina, and can occur by lipid deposition in lipoprotein lipase deficiency. ...
APOA2
high-density lipoprotein particle remodeling. • negative regulation of lipase activity. • regulation of intestinal cholesterol ... spherical high-density lipoprotein particle. • extracellular region. • early endosome. • high-density lipoprotein particle. • ... high-density lipoprotein particle binding. • heat shock protein binding. • receptor binding. Cellular component. • cytosol. • ... lipoprotein metabolic process. • post-translational modification. • cellular protein metabolic process. • transport. • positive ...
Secretion
The best characterized are the RTX toxins and the lipases. Type I secretion is also involved in export of non-proteinaceous ... Porosomes are permanent cup-shaped lipoprotein structure at the cell plasma membrane, where secretory vesicles transiently dock ...
Monoglyceride
... hydrolysis of triglycerides by lipoprotein lipase and the enzymatic hydrolysis of diglycerides by diacylglycerol lipase; or as ...
Glycocalyx
Lipoprotein lipase. *Apolipoproteins. *Growth factors. *Chemokines. The enzymes and proteins listed above serve to reinforce ... Initial dysfunction of the glycocalyx can be caused by hyperglycemia or oxidized low-density lipoproteins (LDLs), which then ...
Lipase, a enciclopedia libre
"Familial lipoprotein lipase deficiency - Genetics Home Reference". Arquivado dende o orixinal o 18 de novembro de 2004. ... Lipases humanasEditar. As principais lipases do aparato dixestivo humano son a lipase pancreática humana (HPL) e a proteína 2 ... Os humanos temos tamén outros encimas relacionados, como a lipase hepática (HL), lipase endotelial, e lipoproteína lipase. Non ... A lipase é un tipo de encima que cataliza hidrólise de lípidos.[1] As lipases son unha subclase de esterases. ...
Hormone-sensitive lipase
lipase activity. • triglyceride lipase activity. • hormone-sensitive lipase activity. • protein binding. • hydrolase activity. ... "Entrez Gene: LIPE lipase, hormone-sensitive".. *^ Kraemer FB, Shen WJ (October 2002). "Hormone-sensitive lipase: control of ... Hormone-sensitive lipase (EC 3.1.1.79, HSL), also previously known as cholesteryl ester hydrolase (CEH),[5] sometimes referred ... LIPE, AOMS4, FPLD6, HSL, LHS, lipase E, hormone sensitive type. External IDs. OMIM: 151750 MGI: 96790 HomoloGene: 3912 ...
Adipose tissue
Free fatty acids are liberated from lipoproteins by lipoprotein lipase (LPL) and enter the adipocyte, where they are ...
چربیهای خون - ویکیپدیا، دانشنامهٔ آزاد
In lipoproteins. Main article: Lipoprotein. Cholesterol is minimally soluble in water; it cannot dissolve and travel in the ... The largest lipoproteins, which primarily transport fats from the intestinal mucosa to the liver, are called chylomicrons. They ... Hyperlipidemia is the presence of elevated or abnormal levels of lipids and/or lipoproteins in the blood, and is a major risk ... After a meal, some of the fatty acids taken up by the liver is converted into very low density lipoproteins (VLDL) and again ...
Gallbladder disease
In testing for gallbladder disease, specifically, liver panel tests and pancreatic enzymes such as lipase will be within normal ... reduced high density lipoprotein (HDL) cholesterol and the metabolic syndrome.[13] ...
Liosta Bithmhóilíní - Vicipéid
Lipase. *Lipid. *Lipid anchored protein. *Lipoamide. *Lipoprotein. *Low density lipoprotein,LDL. *Luteinizing hormone (LH) ...
Glucose 6-phosphatase
Although a clear consensus has not been reached, a large number of scientists adhere to a substrate-transport model to account for the catalytic properties of glucose 6-phosphatase. In this model, glucose 6-phosphatase has a low degree of selectivity. The transfer of the glucose 6-phosphate is carried out by a transporter protein (T1) and the endoplasmic reticulum (ER) contains structures allowing the exit of the phosphate group (T2) and glucose (T3).[6] Glucose 6-phosphatase consists of 357 amino acids, and is anchored to the endoplasmic reticulum (ER) by nine transmembrane helices. Its N-terminal and active site are found on the lumen side of the ER and its C-terminus projects into the cytoplasm. Due to its tight association to the ER, the exact structure of glucose 6-phosphatase remains unknown. However, sequence alignment has shown that glucose 6-phosphatase is structurally similar to the active site of the vanadium-containing chloroperoxidase found in Curvularia inaequalis.[7] Based on pH ...
Virotherapy
... an AAV vector-based gene therapy product for the treatment of lipoprotein lipase deficiency in adults.[24] It was the first ...
Waist-hip ratio
"Characterization of regional and gender differences in glucocorticoid receptors and lipoprotein lipase activity in human ... Whole-grain, ready-to-eat, oat cereal diets reduce low-density lipoprotein cholesterol and waist circumference in overweight or ... reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low- ...
PETase
Tokiwa Y, Suzuki T (November 1977). "Hydrolysis of polyesters by lipases". Nature. 270 (5632): 76-8. doi:10.1038/270076a0. PMID ... PETase exhibits shared qualities with both lipases and cutinases in that it possesses an α/β-hydrolase fold; although, the ... According to ESTHER, it falls into the Polyesterase-lipase-cutinase family. There are approximately 69 PETase-like enzymes ... lipases, esterases, and cutinases.[5] Discoveries of polyester degrading enzymes date at least as far back as 1975 (α- ...
Lipid
Vance JE, Vance DE (2002). Biochemistry of Lipids, Lipoproteins and Membranes. Amsterdam: Elsevier. ISBN 978-0-444-51139-3. .. ... with breakdown controlled mainly by the activation of hormone-sensitive enzyme lipase.[67] The complete oxidation of fatty ... In Vance JE, Vance EE (eds.). Biochemistry of Lipids, Lipoproteins and Membranes (4th ed.). Amsterdam: Elsevier. pp. 373-407. ... The fatty acids may be subsequently converted to triglycerides that are packaged in lipoproteins and secreted from the liver. ...
Phosphoserine phosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is O-phosphoserine phosphohydrolase. This enzyme participates in glycine, serine and threonine metabolism. ...
Fatty acid metabolism
Lipoprotein lipase on the endothelial surfaces of the capillaries, especially in adipose tissue, but to a lesser extent also in ... is carried out by lipases. These lipases are activated by high epinephrine and glucagon levels in the blood (or norepinephrine ... This is catalyzed either by phospholipase A2 acting directly on a membrane phospholipid, or by a lipase acting on DAG (diacyl- ... They are broken down into mono- and di-glycerides plus free fatty acids (but no free glycerol) by pancreatic lipase, which ...
Lysosomal acid lipase deficiency
... elevated low-density lipoprotein cholesterol, decreased high-density lipoprotein cholesterol and elevated serum transaminases.[ ... Lysosomal acid lipase deficiency (LAL deficiency or LAL-D), also known as Wolman disease, is an autosomal recessive inborn ... which is responsible for the gene coding of the lysosomal lipase protein (also called lysosomal acid lipase or LAL), which ... Lysosomal acid lipase deficiency is a genetic disease that is autosomal recessive. It is an inborn error of metabolism that ...
Neonatal jaundice
Third, an enzyme in breast milk called lipoprotein lipase produces increased concentration of nonesterified free fatty acids ... Poland, R L; Schultz GE; Gayatri G (1980). "High milk lipase activity associated with breastmilk jaundice". Pediatr Res. 14 (12 ...
SCARB1
"Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective ... low-density lipoprotein particle binding. • 1-phosphatidylinositol binding. • protein binding. • high-density lipoprotein ... high-density lipoprotein particle receptor activity. • phosphatidylserine binding. • apolipoprotein A-I binding. • ... low-density lipoprotein particle clearance. • blood vessel endothelial cell migration. • positive regulation of cholesterol ...
Blood test
High Density Lipoprotein. Level of "good cholesterol" in the blood (ratio of HDL:LDL is usually more significant than actual ... Lipase *Pancreatic lipase. ‹ The template below (Myeloid blood tests) is being considered for merging. See templates for ... Low Density Lipoprotein. Level of "bad cholesterol" in the blood (ratio of HDL:LDL is usually more significant than actual ...
Glycosaminoglycan
... cell surface binding of lipoprotein lipase and other proteins, angiogenesis, viral invasion, and tumor metastasis.[12]. CSGAGs ...
Triptofaan
"Frameshift mutation in exon 3 of the lipoprotein lipase gene causes a premature stop codon and lipoprotein lipase deficiency". ...
Familial lipoprotein lipase deficiency: MedlinePlus Genetics
Familial lipoprotein lipase deficiency is an inherited condition that disrupts the normal breakdown of fats in the body, ... Mutations that cause familial lipoprotein lipase deficiency lead to a reduction or elimination of lipoprotein lipase activity, ... medlineplus.gov/genetics/condition/familial-lipoprotein-lipase-deficiency/ Familial lipoprotein lipase deficiency. ... Mutations in the LPL gene cause familial lipoprotein lipase deficiency. The LPL gene provides instructions for producing an ...
Lipoprotein lipase: from gene to atherosclerosis. - PubMed - NCBI
Lipoprotein lipase: from gene to atherosclerosis.. Li Y1, He PP2, Zhang DW3, Zheng XL4, Cayabyab FS5, Yin WD6, Tang CK7. ... Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing lipolysis of triglycerides in ... lipoproteins. LPL is produced mainly in adipose tissue, skeletal and heart muscle, as well as in macrophage and other tissues. ...
Lipoprotein lipase - Wikipedia
NIH/UW entry on Familial Lipoprotein Lipase Deficiency Gene therapy for lipoprotein lipase deficiency Lipoprotein+lipase at the ... Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase ... "Entrez Gene: LPL lipoprotein lipase". Wang H, Eckel RH (2009). "Lipoprotein lipase: from gene to obesity". Am J Physiol ... Zechner R (1997). "The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism". ...
Lipoprotein lipase deficiency - Wikipedia
Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads ... More than 220 mutations in the LPL gene have been found to cause familial lipoprotein lipase deficiency so far. Treatment of ... "Familial lipoprotein lipase deficiency: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 17 April 2019. Burnett, ... "Familial Lipoprotein Lipase Deficiency". In Adam, MP; Ardinger, HH; Pagon, RA; et al. (eds.). GeneReviews. Seattle: University ...
Search of: 'familial lipoprotein lipase deficiency' - List Results - ClinicalTrials.gov
Glybera Registry, Lipoprotein Lipase Deficient (LPLD) Patients. *Lipoprotein Lipase Deficiency. *Familial Hyperlipoproteinemia ... Lipoprotein Lipase Enzyme Activity Assay Validation and Clinical Assessment. *Lipoprotein Lipase Deficiency ... Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enrolled on AMT Clinical Studies. *Lipoprotein Lipase ... an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X]. *Familial Lipoprotein Lipase Deficiency ...
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis | PNAS
Lipoprotein lipase (LPL) is responsible for the intravascular processing of triglyceride-rich lipoproteins. The LPL within ... The intravascular processing of triglyceride-rich lipoproteins by the lipoprotein lipase (LPL)-GPIHBP1 complex is crucial for ... Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Gabriel Birrane, Anne P. ... Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis ...
Molecular cloning and sequence of a cDNA coding for bovine lipoprotein lipase | PNAS
Molecular cloning and sequence of a cDNA coding for bovine lipoprotein lipase. M Senda, K Oka, W V Brown, P K Qasba, and Y ... Lipoprotein lipase (LPL; triacylglycero-protein acylhydrolase, EC 3.1.1.34) was purified from bovine milk. Synthetic ... Molecular cloning and sequence of a cDNA coding for bovine lipoprotein lipase ... Molecular cloning and sequence of a cDNA coding for bovine lipoprotein lipase ...
Lipoprotein lipase transporter GPIHBP1 and triglyceride-rich lipoprotein metabolism. - PubMed - NCBI
Lipoprotein lipase transporter GPIHBP1 and triglyceride-rich lipoprotein metabolism.. Liu C1, Li L2, Guo D3, Lv Y3, Zheng X4, ... Increased plasma triglyceride serves as an independent risk factor for cardiovascular disease (CVD). Lipoprotein lipase (LPL), ... Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), a newly identified factor, appears ... of evidence indicate that GPIHBP1 exerts distinct functions and plays diverse roles in human triglyceride-rich lipoprotein (TRL ...
Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia - Full Text View - ClinicalTrials.gov
Recent Articles | Lipoprotein Lipase Deficiency And Microbiology | The Scientist Magazine®
Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. | Diabetes
Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.. G Mingrone, F L Henriksen, A V Greco, L ... Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.. G Mingrone, F L Henriksen, A V Greco, L ... Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. Message Subject (Your Name) has forwarded ... and postheparin plasma lipoprotein lipase (LPL) activity. In addition, GC-clamped polymerase chain reaction-amplified DNA from ...
Anti-Lipoprotein lipase antibody [LPL.A4] (ab21356) | Abcam
Mouse monoclonal Lipoprotein lipase antibody [LPL.A4]. Validated in WB, ELISA, IHC, Flow Cyt, ICC/IF and tested in Mouse, Cow, ... Lane 1 : Human Lipoprotein lipase.. Lane 2 : Bovine Lipoprotein lipase. Lysates/proteins at 10 µg per lane.. Predicted band ... Anti-Lipoprotein lipase antibody [LPL.A4]. See all Lipoprotein lipase primary antibodies. ... Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Lipoprotein lipase antibody [LPL.A4]. ...
Lipoprotein Lipase S447X | Arteriosclerosis, Thrombosis, and Vascular Biology
Lipoprotein lipase transport in plasma: role of muscle and adipose tissues in regulation of plasma lipoprotein lipase ... Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humans. ... Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase ... Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk. Curr Atheroscler Rep. 2004; 6: 335-342. ...
Lipoprotein lipase deficiency in an infant | Amrita Vishwa Vidyapeetham
Lipoprotein Lipase, lipoprotein lipase gene, low fat diet, male, medium chain triacylglycerol, multivitamin, promoter region, ... Sa Nampoothiri, Radhakrishnan, Nb, Schwentek, Ac, and Hoffmann, M. Ma, "Lipoprotein lipase deficiency in an infant", Indian ... The child was found to be heterozygous for two novel mutations in the lipoprotein lipase gene. ... triacylglycerol, very low density lipoprotein Abstract:. Patients with isolated hypertriglyceridemia usually present with ...
Lipoprotein Lipase (LPL)
CiNii Articles -
A Study of Catalytic Function and Structure of Lipoprotein Lipase.
リポ蛋白リパーゼの活性発現機構に関する研究 [in Japanese] A Study of Catalytic Function and Structure of Lipoprotein Lipase. [in Japanese] * * 田代 淳 ... We studied the catalytic process of lipoprotein lipase (LPL) and the structure which affects the catalytic activity of LPL. LPL ... しかしtriolein添加によるtributyrin水解活性上昇反応はみらWe studied the catalytic process of lipoprotein lipase (LPL) and the structure which ... The trypsin-treated LPL retained the ability to
Familial Lipoprotein Lipase Deficiency - Renal and Urology News
This rare autosomal recessive disorder (frequency 1 per million) is characterized by the absence of lipoprotein lipase (LPL) ... and hepatic lipase deficiency). LPL promoter mutations are not rare and may contribute to the lipoprotein phenotype of FCH, at ... Lipoproteins, Lipids Similarly Linked With MI, Ischemic Stroke. *Familial Hypercholesterolemia Ups Risk of Cardiovascular ... and lowered high-density lipoprotein cholesterol (HDL-C; often ,0.5 mmol/L) in plasma. VLDL levels may remain fairly normal. ...
Lipoprotein Lipase/LPL Mouse anti-Human, Alexa Fluor 405, Clone: OTI3A10,
| Fisher Scientific
Lipoprotein Lipase/LPL Mouse anti-Human, Alexa Fluor 405, Clone: OTI3A10, Novus Biologicals 0.1 mL; Alexa Fluor 405 ... Lipoprotein Lipase/LPL Monoclonal antibody specifically detects Lipoprotein Lipase/LPL in Human samples. It is validated for ... Lipoprotein Lipase/LPL Mouse anti-Human, Alexa Fluor 405, Clone: OTI3A10, Novus Biologicals ... Recombinant protein fragment corresponding to amino acids 28-475 of human Lipoprotein Lipase/LPL (NP_000228) produced in ...
Familial Lipoprotein Lipase Deficiency - Clinical Advisor
This rare autosomal recessive disorder (frequency 1 per million) is characterized by the absence of lipoprotein lipase (LPL) ... and hepatic lipase deficiency). LPL promoter mutations are not rare and may contribute to the lipoprotein phenotype of FCH, at ... and lowered high-density lipoprotein cholesterol (HDL-C; often ,0.5 mmol/L) in plasma. VLDL levels may remain fairly normal. ... massive plasma elevations of the large lipoprotein particles that originate from dietary fat, with a concomitant increase in TG ...
JCI -
Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
Although lipoprotein lipase is expressed by and is found on the surface of cardiomyocytes, its transfer to the luminal surface ... Lipoprotein lipase is the principal enzyme that hydrolyzes circulating triglycerides and liberates free fatty acids that can be ... Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. ... Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. ...
Lipoprotein Lipase/LPL Antibody Pair (H00004023-PW1): Novus Biologicals
Lipoprotein Lipase/LPL Antibody Pair. Matched antibody pairs validated for ELISA or IP-Western Blot. Backed by our 100% ... Additional Lipoprotein Lipase/LPL Products. Lipoprotein Lipase/LPL H00004023-PW1 * Lipoprotein Lipase/LPL Antibodies ... Home » Lipoprotein Lipase/LPL » Lipoprotein Lipase/LPL Antibody Pairs » Lipoprotein Lipase/LPL Antibody Pair ... Blogs on Lipoprotein Lipase/LPL. There are no specific blogs for Lipoprotein Lipase/LPL, but you can read our latest blog posts ...
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
Lipoprotein lipase plays a central role in lipid metabolism and the gene that encodes this enzyme (LPL) is a candidate ... DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene Nat Genet. 1998 Jul;19(3):233-40. doi: 10.1038/ ... Lipoprotein lipase plays a central role in lipid metabolism and the gene that encodes this enzyme (LPL) is a candidate ...
Lipoprotein Lipase & Insulin | Healthy Eating | SF Gate
Insulin and lipoprotein lipase work together in your body to use extra calories from carbohydrates in your diet to make and ... Lipoprotein Lipase & Insulin. Written by Michael R. Peluso, Ph.D.; Updated December 27, 2018 Lipoprotein Lipase & Insulin ... Lipoprotein Lipase. Lipoprotein lipase is an enzyme that is important for the transfer of triglycerides from your blood ... healthyeating.sfgate.com/lipoprotein-lipase-insulin-6065.html R., Michael. "Lipoprotein Lipase & Insulin" last modified ...
Lipoprotein lipase deficiency familial - Biology-Online Dictionary | Biology-Online Dictionary
Lipoprotein lipase deficiency, familial a rare familial condition characterised by massive chylomicronaemia and decreased ... It is due to deficiency of lipoprotein lipase, an alkaline triglyceride hydrolase which catalyses an important step in the ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Lipoprotein_lipase_deficiency_familial&oldid=55852" ...
Joint Linkage and Association Analysis of Hepatic Lipase Promoter Polymorphism and Lipoprotein Size Phenotypes | Circulation
Joint Linkage and Association Analysis of Hepatic Lipase Promoter Polymorphism and Lipoprotein Size Phenotypes. Laura Almasy, ... Joint Linkage and Association Analysis of Hepatic Lipase Promoter Polymorphism and Lipoprotein Size Phenotypes ... Joint Linkage and Association Analysis of Hepatic Lipase Promoter Polymorphism and Lipoprotein Size Phenotypes ... Joint Linkage and Association Analysis of Hepatic Lipase Promoter Polymorphism and Lipoprotein Size Phenotypes ...
Design, synthesis and evaluation of photoaffinity chemical probe to study Lipoprotein lipase - small molecule interactions
Unusual metabolic characteristics in skeletal muscles of transgenic rabbits for human lipoprotein lipase.
... hydrolyses circulating triacylglycerol-rich lipoproteins. Thereby, LPL acts as a metabolic gate-keeper for fatty acids ... Lipoprotein lipase activity Lipoprotein lipase (LPL) activity was assessed after homogenization of the tissues in a buffer ... Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake ... BACKGROUND: The lipoprotein lipase (LPL) hydrolyses circulating triacylglycerol-rich lipoproteins. Thereby, LPL acts as a ...
Breast milk jaundice; the role of lipoprotein lipase and the free fatty acids
The lipoprotein lipase and free fatty acid values in the milk from mothers of infants without jaundice were found to increas … ... Lipoprotein lipase activity and free fatty acid concentrations were measured in samples of milk collected from mothers of ... Breast milk jaundice; the role of lipoprotein lipase and the free fatty acids Eur J Pediatr. 1980 Jun;134(1):35-8. doi: 10.1007 ... The lipoprotein lipase and free fatty acid values in the milk from mothers of infants without jaundice were found to increase ...
Study on Lipoprotein Lipase Production by Candida rugosa
Candida rugosa can produce lipoprotein lipase by fermentation in the medium on a rotary shaker, the optimal medium compositions ... HomeAdvanced Materials ResearchMaterials for Environmental Protection and Energy...Study on Lipoprotein Lipase Production by ... X. X. Zhao and Y. G. He, "Study on Lipoprotein Lipase Production by Candida rugosa", Advanced Materials Research, Vols. 343-344 ... Candida rugosa can produce lipoprotein lipase by fermentation in the medium on a rotary shaker, the optimal medium compositions ...
Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease...
Li Xie, You-Mei Li, Lipoprotein Lipase (LPL) Polymorphism and the Risk of Coronary Artery Disease: A Meta-Analysis, ... Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease ... and lipoprotein lipase (LPL). The relationship between CETP MspI, apo E and LPL PvuII gene polymorphisms and serum lipids were ... Lipoprotein lipase gene variants: Association with acute myocardial infarction and lipid profiles, Egyptian Journal of Medical ...
DeficiencyTriglyceridesGeneAbstractMetabolismCholesterolLipidsEndothelial lipaseChylomicronsMutationsApolipoproteinVLDLPolymorphismParticlesAdipose tissue lipoprotein lipase activityProteinDensityInsulinPost-heparinPancreaticLipolyticFree fattyAntibodyRegulationActivity Assay KitGeneticAtherosclerosisCapillary endothelial cellsInhibitionHumansCardiovascular diseaseSkeletal muscleUptakeMonoclonalPostprandialPlasmaEnzyme activityBovine
Deficiency45
- Familial lipoprotein lipase deficiency is an inherited condition that disrupts the normal breakdown of fats in the body, resulting in an increase of certain kinds of fats. (medlineplus.gov)
- People with familial lipoprotein lipase deficiency typically develop signs and symptoms before age 10, with one-quarter showing symptoms by age 1. (medlineplus.gov)
- Approximately half of individuals with familial lipoprotein lipase deficiency develop small yellow deposits of fat under the skin called eruptive xanthomas. (medlineplus.gov)
- The blood of people with familial lipoprotein lipase deficiency can have a milky appearance due to its high fat content. (medlineplus.gov)
- In people with familial lipoprotein lipase deficiency, increased fat levels can also cause neurological features, such as depression , memory loss, and mild intellectual decline (dementia). (medlineplus.gov)
- Mutations in the LPL gene cause familial lipoprotein lipase deficiency. (medlineplus.gov)
- Mutations that cause familial lipoprotein lipase deficiency lead to a reduction or elimination of lipoprotein lipase activity, which prevents the enzyme from effectively breaking down triglycerides. (medlineplus.gov)
- As a result, triglycerides attached to lipoproteins build up in the blood and tissues, leading to the signs and symptoms of familial lipoprotein lipase deficiency. (medlineplus.gov)
- Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. (wikipedia.org)
- Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead to problems with the pancreas and liver, which in turn can lead to diabetes. (wikipedia.org)
- ApoC2, ApoA5, LMF-1, GPIHBP-1 and GPD1) should also be considered The diagnosis of familial lipoprotein lipase deficiency is finally confirmed by detection of either homozygous or compound heterozygous pathogenic gene variants in LPL with either low or absent lipoprotein lipase enzyme activity. (wikipedia.org)
- More than 220 mutations in the LPL gene have been found to cause familial lipoprotein lipase deficiency so far. (wikipedia.org)
- Also searched for Hyperlipoproteinemia Type I , Lipoprotein lipase deficiency , and Familial Chylomicronemias . (clinicaltrials.gov)
- Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. (diabetesjournals.org)
- Familial LPL deficiency should be considered in anybody with the chylomicronemia syndrome (massive plasma elevations of the large lipoprotein particles that originate from dietary fat, with a concomitant increase in TG concentrations), especially in the absence of secondary causes of hypertriglyceridemia. (renalandurologynews.com)
- More severe hypertriglyceridemia can occur in compound heterozygotes, when other known genetic defects are present in addition to the heterozygous LPL state (e.g., the apoE2 allele, familial combined hyperlipidemia (FCH) and hepatic lipase deficiency). (renalandurologynews.com)
- It is due to deficiency of lipoprotein lipase , an alkaline triglyceride hydrolase which catalyses an important step in the extrahepatic removal of triglyceride -rich lipoproteins from the blood . (biology-online.org)
- Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome. (thefreedictionary.com)
- Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation. (thefreedictionary.com)
- Indeed, the rare autosomal recessive deficiency of apo C2 can lead to a decrease in lipoprotein lipase deficiency as profound as that in familial lipoprotein lipase deficiency (34, 35). (thefreedictionary.com)
- Glybera is a gene therapy for patients with the genetic disorder lipoprotein lipase deficiency (LPLD). (thefreedictionary.com)
- This trial is designed to expand the currently available data on the safety and efficacy of alipogene tiparvovec treatment in lipoprotein lipase deficiency (LPLD) and to further the understanding of possible mechanisms of action of the therapy. (clinicaltrials.gov)
- The goal of this study was to characterize the effect of microcoated fenofibrate (160 mg/day for 6 months) on plasma lipoprotein composition and kinetics in 2 patients with complete hepatic lipase (HL) deficiency. (unboundmedicine.com)
- 53 Familial lipoprotein lipase deficiency is a rare genetic disorder is which a person lacks the enzyme lipoprotein lipase, a protein needed to break down fat molecules. (malacards.org)
- Familial Lipoprotein Lipase Deficiency, also known as familial lpl deficiency , is related to hyperlipoproteinemia, type v and pancreatitis . (malacards.org)
- An important gene associated with Familial Lipoprotein Lipase Deficiency is LPL (Lipoprotein Lipase), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors . (malacards.org)
- 12 A familial hyperlipemia characterized by a deficiency of the enzyme lipoprotein lipase and the subsequent build up of chylomicrons and increased plasma concentration of triglycerides. (malacards.org)
- DAG oil was evaluated in healthy cats and in a feline model of hypertriglyceridemia as a result of lipoprotein lipase (LPL) deficiency. (umsystem.edu)
- Familial lipoprotein lipase deficiency is caused by a defective gene that is passed down through families. (baptistjax.com)
- Risk factors include a family history of lipoprotein lipase deficiency. (baptistjax.com)
- Pancreatitis that is related to lipoprotein lipase deficiency responds to treatments for that disorder. (baptistjax.com)
- Call your provider for screening if someone in your family has lipoprotein lipase deficiency. (baptistjax.com)
- similar in symptoms to familial lipoprotein lipase deficiency. (lexic.us)
- Molecular basis of lipoprotein lipase deficiency in two Austrian families with type I hyperlipoproteinemia. (ox.ac.uk)
- To determine the molecular basis for type I hyperlipoproteinemia in two Austrian families, the lipoprotein lipase (LPL) gene of two patients exhibiting LPL deficiency was analyzed by Southern blotting and by direct genomic sequencing of DNA amplified by polymerase chain reaction (PCR). (ox.ac.uk)
- Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein. (ox.ac.uk)
- Hepatic lipase deficiency produces significant distortion in the plasma lipoprotein profile. (ox.ac.uk)
- The present study examines apolipoprotein B turnover in a patient with hepatic lipase deficiency. (ox.ac.uk)
- Objective - To assess effects of deficiency of lipoprotein lipase (LPL) on body condition scores and lean and fat body masses of adult cats. (elsevier.com)
- She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in the presence of the apolipoprotein E3/2 genotype. (kjim.org)
- Babirak, S.P et al: The detection and characterization of the heterozygote state for lipoprotein lipase deficiency. (immuquest.com)
- What is the definition of Familial Lipoprotein Lipase Deficiency? (medifind.com)
- What are the causes for Familial Lipoprotein Lipase Deficiency? (medifind.com)
- How prevalent is Familial Lipoprotein Lipase Deficiency? (medifind.com)
- Is Familial Lipoprotein Lipase Deficiency an inherited disorder? (medifind.com)
Triglycerides24
- This enzyme helps break down fats called triglycerides, which are carried by molecules called lipoproteins . (medlineplus.gov)
- It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. (wikipedia.org)
- Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing lipolysis of triglycerides in lipoproteins. (nih.gov)
- The intravascular processing of triglyceride-rich lipoproteins by the lipoprotein lipase (LPL)-GPIHBP1 complex is crucial for clearing triglycerides from the bloodstream and for the delivery of lipid nutrients to vital tissues. (pnas.org)
- The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). (abcam.com)
- Lipoprotein lipase (LPL) hydrolyzes triglycerides in the circulation and promotes the hepatic uptake of remnant lipoproteins. (ahajournals.org)
- 1 The main function of this enzyme is the hydrolysis of plasma triglycerides (TGs) that are packaged in apolipoprotein (apo) B containing lipoproteins. (ahajournals.org)
- Lipoprotein lipase is the principal enzyme that hydrolyzes circulating triglycerides and liberates free fatty acids that can be used as energy by cardiac muscle. (jci.org)
- Lipoprotein lipase then provides essential assistance for the transfer of triglycerides from the lipoproteins in your blood to your fatty tissues, heart and muscles. (sfgate.com)
- Lipoprotein lipase is an enzyme that is important for the transfer of triglycerides from your blood lipoproteins into your tissues. (sfgate.com)
- Lipoprotein lipase breaks down the triglycerides in the lipoproteins to smaller fatty acids and monoglycerides that are transported into your tissues and either burned for fuel or re-assembled into triglycerides for storage. (sfgate.com)
- Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). (healthtap.com)
- We studied the activity and expression of lipoprotein lipase (LPL), which catalyzes the hydrolysis of plasma triglycerides, in different ocular regions. (epfl.ch)
- LPL hydrolyzes triglycerides in plasma lipoproteins. (diva-portal.org)
- The effects of polymorphisms in the lipoprotein lipase (LPL) gene (HindIII and S447X) and in the apolipoprotein (apo) AI-CIII gene cluster (G75A and C1100T) on levels of fasting plasma triglycerides, apoCIII, high density lipoprotein cholesterol (HDL-C), and apoAI were examined in 315 healthy men and women from Iceland. (unboundmedicine.com)
- Lipoprotein lipase (LPL), an enzyme which hydrolyzes triglycerides and participates in the catabolism of remnant lipoproteins, plays a crucial role in energy and lipid metabolism. (epfl.ch)
- In mammals, GPIHBP1 is absolutely essential for transporting lipoprotein lipase (LPL) to the lumen of capillaries, where it hydrolyzes the triglycerides in triglyceride-rich lipoproteins. (jci.org)
- Hepatic lipase (HL) and endothelial lipase (EL) are extracellular lipases that both hydrolyze triglycerides and phospholipids and display potentially overlapping or complementary roles in lipoprotein metabolism. (ahajournals.org)
- 1 , - , 6 These 3 heparin-binding lipases are anchored to the endothelial surface and mediate the hydrolysis of triglycerides (TGs) and phospholipids (PLs) within circulating lipoproteins. (ahajournals.org)
- Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619, PubMed:11342582, PubMed:27578112). (sdsc.edu)
- lipo·pro·tein li·pase (lip″o-proґtēn liґpās) [EC 3.1.1.34] an enzyme of the hydrolase class that catalyzes the hydrolytic cleavage of fatty acyl groups from triglycerides (or di- or monoglycerides) in chylomicrons, very-low-density lipoproteins, and low-density lipoproteins. (enacademic.com)
- lipoprotein lipase - an enzyme that catalyses the hydrolysis of triglycerides in chylomicrons and very low density lipoproteins to free fatty acids, which are absorbed from the capillaries into local tissues. (enacademic.com)
- Lipase is transported through the pancreatic duct into the first part of the small intestine ( ) where it helps break down dietary triglycerides ( a form of fat) into fatty acids. (natrilha.info)
- Use Lipoprotein Lipase in diagnostic tests for the determination of triglycerides together with Glycerol Kinase, Catalog No. 10 539 937 103 or 11 499 530 103 and Glycerol-3-phosphate Dehydrogenase, Catalog No. 11 654 730 103 or 11 582 003 103. (roche.com)
Gene18
- Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. (wikipedia.org)
- LPL gene encodes lipoprotein lipase, which is expressed in the heart, muscle, and adipose tissue. (wikipedia.org)
- Lipoprotein lipase: from gene to atherosclerosis. (nih.gov)
- The LPL gene locus is highly polymorphic and many single nucleotide polymorphisms (SNP) in both coding and noncoding regions have been used to study associations with lipids, lipoproteins, and risk for atherosclerosis. (ahajournals.org)
- The child was found to be heterozygous for two novel mutations in the lipoprotein lipase gene. (amrita.edu)
- Lipoprotein lipase plays a central role in lipid metabolism and the gene that encodes this enzyme (LPL) is a candidate susceptibility gene for cardiovascular disease. (nih.gov)
- The hepatic lipase gene (LIPC) has repeatedly been implicated as a potential regulator of HDL cholesterol concentration and HDL and LDL particle size. (ahajournals.org)
- The aim of this study was to compare patients with coronary artery disease (CAD) to healthy objects, in order to explore a possible association between CAD and the variants in the gene encoding cholesterol ester transfer protein (CETP), apolipoprotein E (Apo E) and lipoprotein lipase (LPL). (wiley.com)
- Association between lipoprotein lipase (LPL) gene and blood lipids: A common variant for a common trait? (wiley.com)
- Background -Recently, a mutation in the lipoprotein lipase (LPL) gene (N291S) has been reported in 2% to 5% of individuals in western populations and is associated with increased triglyceride (TG) and reduced HDL cholesterol (HDLC) concentrations. (ahajournals.org)
- 4. Eight of the subjects were found to possess genetic variants at the lipoprotein lipase gene locus. (clinsci.org)
- Comparative gene identification‑58 (CGI‑58) and lipoprotein lipase (LPL) are involved in the first step of triglyceride hydrolysis and serve an important role in lipid transport in the placenta. (spandidos-publications.com)
- Mutations of the human LPL-gene have been shown to cause partial or complete malfunction of the enzyme, resulting in accumulation of lipoproteins in the blood. (uni-muenchen.de)
- Based on these findings we were evaluating a possible role of the lipoprotein lipase gene in the development of pancreatitis and hyperlipidemia in the Miniature Schnauzer. (uni-muenchen.de)
- We conclude that pancreatitis associated with hyperlipidemia in the Miniature Schnauzer is not linked to mutations of the lipoprotein lipase gene or its splicing regions. (uni-muenchen.de)
- The Effects of Dietary Fatty Acids On Lipoprotein Lipase Activity and Gene Expression. (surrey.ac.uk)
- The aim of the study was to evaluate the influence of single nucleotide polymorphism (SNP) in lipoprotein lipase gene (LPL) on the basic sheep milk parameters and the fatty acid profile in milk and yoghurt drinks made from it. (vuzv.cz)
- Peterson, J.et al: Structural and functional consequences of missense mutations in Exon 5 of the lipoprotein lipase gene. (immuquest.com)
Abstract2
- article{5a0b5a06-4e09-4a23-a38a-02712684b3d8, abstract = {The location of lipoprotein lipase activity in rat adipose tissue was studied using intact epididymal fat pads, isolated adipocytes, and lipoprotein lipase activity secreted from adipocytes as enzyme sources. (lu.se)
- Abstract Lipoprotein lipase (LPL), the enzyme responsible for hydrolyzing triglyceride (TG) in plasma lipoproteins, is a key regulator of plasma TG levels. (semanticscholar.org)
Metabolism16
- Lipoprotein lipase transporter GPIHBP1 and triglyceride-rich lipoprotein metabolism. (nih.gov)
- Lipoprotein lipase (LPL), which hydrolyzes circulating triglyceride, plays a crucial role in normal lipid metabolism and energy balance. (nih.gov)
- Numerous lines of evidence indicate that GPIHBP1 exerts distinct functions and plays diverse roles in human triglyceride-rich lipoprotein (TRL) metabolism. (nih.gov)
- Lipoprotein lipase (LPL) plays a central role in human lipid homeostasis and energy metabolism. (ahajournals.org)
- LPL plays a pivotal role in lipids and the metabolism of lipoprotein. (omicsonline.org)
- Ocular tissues are highly dependent on lipid turnover and metabolism, which requires an uptake mechanism for fatty acids from lipoproteins. (epfl.ch)
- FH is a common autosomal dominant disorder of lipoprotein metabolism, affecting ≈1 in 500 people in the western world. (ahajournals.org)
- To this end, we explored the effect of CsA therapy on hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (the rate-limiting enzyme in cholesterol synthesis), LDL, and high-density lipoprotein (HDL) receptors (the critical factors in metabolism of the cholesterol-rich LDL and HDL particles), and of cholesterol 7α-hydroxylase, (the rate-limiting step in cholesterol catabolism to bile acids). (aspetjournals.org)
- OBJECTIVE To evaluate the impact of chronic inflammation on lipoprotein lipase (LPL) levels and tri-glyceride metabolism in patients wit rheumatoid arthritis (RA). (semanticscholar.org)
- These studies reveal an additive effect of HL and EL on HDL metabolism but not macrophage reverse cholesterol transport in mice and an unexpected redundant role of HL and EL in apolipoprotein B lipoprotein metabolism. (ahajournals.org)
- Both HL and EL influence the metabolism of high-density lipoproteins (HDLs). (ahajournals.org)
- HL also modulates the metabolism of apolipoprotein (apo)B-containing lipoproteins (LpBs). (ahajournals.org)
- The metabolism of large and small very low density lipoproteins was determined in four control subjects and compared to the pattern seen in the patient. (ox.ac.uk)
- Since mice lacking neuronal lipoprotein lipase (LPL) develop perturbations in neuronal lipid-sensing and systemic energy balance, we reasoned that LPL might be a component of pre-autonomic neurons involved in the regulation of hepatic metabolism. (preprints.org)
- BackgroundLysosomal acid lipase is an essential lipid- metabolizing enzyme that breaks down endocytosed lipid particles and regulates lipid metabolism. (natrilha.info)
- Lipoprotein lipase (LPL) plays a critical role in the metabolism of lipoproteins because this enzyme hydrolyzes the triacylglycerides in chylomicrons and very low density lipoproteins. (edu.au)
Cholesterol20
- It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. (wikipedia.org)
- it has a higher affinity for large triacylglyceride-rich lipoproteins than cholesterol-rich lipoproteins. (wikipedia.org)
- These mutations occur at high frequencies in the general population (up to 5%) and are associated with elevated TGs, decreased high-density lipoprotein (HDL) cholesterol levels, and concomitantly with a higher incidence of cardiovascular disease (CVD), 6-13 compared with noncarriers. (ahajournals.org)
- In the CAD group, those with the Msp M1 allele had higher levels of total cholesterol (TC) (p = 0026) and low-density lipoprotein cholesterol (LDL-C) than those with the Msp M2 allele. (wiley.com)
- In the control group, CETP, the Msp M2 allele was associated with a higher level of high-density lipoprotein cholesterol (HDL-C) (p = 0.012) than the Msp M1 allele. (wiley.com)
- I had Fasting test Cholesterol 158/triglyceride 45/ HDL 77 / LDL calculated 72 \cholesterol high density lipoprotein 2.1 /cholesterol nonHDL81 Normal? (healthtap.com)
- The kinetics of plasma apoA-I and apoA-II as well as the capacity of total plasma and of high-density lipoprotein particles to efflux cellular cholesterol from normal human skin fibroblasts was not altered by fenofibrate. (unboundmedicine.com)
- Thus, hepatic expressions of cholesterol 7α-hydroxylase (the rate-limiting step in cholesterol conversion to bile acids), LDL receptor, and high-density lipoprotein (HDL) receptor proteins, as well as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity were determined in rats treated with CsA (18 mg/kg/day) or placebo for 3 weeks. (aspetjournals.org)
- This was associated with a marked down-regulation of cholesterol 7α-hydroxylase in the liver and a severe reduction of lipoprotein lipase abundance in skeletal muscle and adipose tissue. (aspetjournals.org)
- In conclusion, CsA administration for 3 weeks resulted in a significant reduction of hepatic cholesterol 7α-hydroxylase and marked down-regulation of skeletal muscle and adipose tissue lipoprotein lipase abundance in rats. (aspetjournals.org)
- The former abnormality can contribute to hypercholesterolemia by limiting cholesterol catabolism, whereas the latter may contribute to hypertriglyceridemia and VLDL accumulation by limiting triglyceride-rich lipoprotein clearance in CsA-treated animals. (aspetjournals.org)
- The plasma levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, and phospholipids in the HL/EL-dko mice were markedly higher than those in the single-knockout mice. (ahajournals.org)
- HDL from all 3 lipase knockout models had an increased cholesterol efflux capacity but reduced clearance of HDL cholesteryl esters versus control mice. (ahajournals.org)
- lipoprotein - n. one of a group of compounds, found in blood plasma and lymph, each consisting of a protein (see apolipoprotein) combined with a lipid (which may be cholesterol, a triglyceride, or a phospholipid). (enacademic.com)
- Lipase is absolutely key to proper fat digestion, which affects so many bodily functions as well as health st Heart Rate Zone For Fat Burn - Weight Loss Clinic Opelousas La Best Heart Rate Zone For Fat Burn Hdl High Density Lipoprotein Cholesterol Weight Loss Management In Flint Mi. (natrilha.info)
- A review of low- density lipoprotein cholesterol its impact on cardiovascular disease morbidity , treatment strategies mortality. (natrilha.info)
- The study has broad- ranging implications relative to increased free radical damage , although carried out on pigs loss of mitochondria productionThis is a st Heart Rate Zone For Fat Burn - Weight Loss Clinic Opelousas La Best Heart Rate Zone For Fat Burn Hdl High Density Lipoprotein Cholesterol Weight Loss Management In. (natrilha.info)
- Body fat decreases in total low- density lipoprotein cholesterol were greater in women whose adipose tissue LPL activity decreased with weight loss. (natrilha.info)
- This process influences the production of high-density lipoprotein (HDL), which takes up tissue cholesterol for transport to the liver for excretion. (edu.au)
- To help clarify this issue, we investigated 144 outwardly healthy male Mediterranean migrants (from Italy and Greece), age between 40 and 70 years and resident in Australia, for associations between two common LPL restriction site polymorphisms and the following lipid and lipoprotein phenotypes: total plasma cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triacylglycerides. (edu.au)
Lipids7
- 76 Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood. (malacards.org)
- As the underlying mechanism of the enhancing effect has not been investigated previously, we here show that in the presence of soybean 15LO (SLO) or human 15LO (rhLO), the addition of lipoprotein lipase, porcine pancreatic, or human type IIa secretory phospholipase A2 (sPLA2) greatly enhanced the accumulation of hydro(pero)xides of all major classes of LDL's lipids. (garvan.org.au)
- With SLO, formation of oxidized esterified lipids occurred nonenzymically, independent of the presence of lipase and despite the oxygenase remaining active until the end of the incubation. (garvan.org.au)
- LDL depleted of alpha-tocopherol was resistant to oxidation by 15LO alone, whereas lipase overcame this resistance, demonstrating that lipases enhance 15LO-induced enzymic and nonenzymic peroxidation of LDL lipids. (garvan.org.au)
- 3.1.1.34) is an enzyme that hydrolyzes lipids in lipoproteins, like those found in chylomicrons and very low density lipoproteins (VLDL), into three free fatty acids and one glycerol molecule. (enacademic.com)
- green (phospholipids)] A lipoprotein is a biochemical assembly that contains both proteins and lipids. (enacademic.com)
- We investigated the effect of HMBA on hyperlipidaemia induced by ethanol, exploring food intake, body weight, and hepatic and plasma lipids and lipoproteins. (isharonline.org)
Endothelial lipase2
- Hepatic lipase (HL) and endothelial lipase (EL) are members of an extracellular lipase family that includes lipoprotein lipase (LPL). (ahajournals.org)
- This study was performed to compare the effects of three different lipid-lowering therapies (statins, ezetimibe, and colestimide) on lipoprotein lipase and endothelial lipase masses in pre-heparin plasma (pre-heparin LPL and EL mass, respectively) from patients with familial hypercholesterolemia (FH). (biomedcentral.com)
Chylomicrons7
- Lipoprotein lipase can bind with your blood lipoproteins, including VLDL from your liver and chylomicrons from your small intestine, after a meal. (sfgate.com)
- Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. (healthtap.com)
- In addition, we determined the effects of CsA therapy on skeletal muscle and adipose tissue abundance of lipoprotein lipase and the novel VLDL receptor, which are the principal clearance pathways of triglyceride-rich lipoproteins, namely, chylomicrons and VLDL. (aspetjournals.org)
- It catalyses the hydrolysis of the triacylglycerol component of chylomicrons and very low-density lipoproteins (VLDL), providing non-esterified fatty acids for tissue utilization. (uni-muenchen.de)
- The primary sources of these extracellular fatty acids are those that are 1) associated with circulating albumin or 2) hydrolyzed from triacylglycerol-rich lipoprotein particles such as chylomicrons or very low density lipoproteins (VLDL). (biomedcentral.com)
- Lipoprotein lipase activity was studied in rat parametrial adipose tissue perfused with chylomicrons and in gelatin blocks containing postheparin plasma and chylomicrons. (rupress.org)
- It hydrolyzes triacylglycerols in chylomicrons, lipoproteins and diacylglycerols. (roche.com)
Mutations3
- In this instance besides LPL also other loss-of-function mutations in genes that regulate catabolism of triglyceride-rich lipoproteins (like e.g. (wikipedia.org)
- LPL promoter mutations are not rare and may contribute to the lipoprotein phenotype of FCH, at least in the subset of patients who show reduced postheparin plasma LPL activity. (renalandurologynews.com)
- T polymorphism can not explain the observed linkage of lipoprotein size phenotypes to the LIPC region and, therefore, that there are one or more additional functional mutations in or near LIPC influencing HDL, and potentially LDL, size variation. (ahajournals.org)
Apolipoprotein1
- ApoC-II was the only apolipoprotein from human very low density lipoprotein that activated rat adipose tissue lipoprotein lipase. (ahajournals.org)
VLDL9
- The fats made in your liver from extra carbohydrates in your diet are packaged into blood transporters called very low-density lipoproteins, or VLDL, which are shipped into your blood. (sfgate.com)
- Long-term administration of cyclosporine (CsA) has been shown to cause hypercholesteremia, hypertriglyceridemia, and elevations of plasma low-density and very low-density lipoprotein (LDL and VLDL) levels in humans. (aspetjournals.org)
- In addition, skeletal muscle and adipose tissue expressions of lipoprotein lipase and VLDL receptor were measured. (aspetjournals.org)
- Objective Circulating hepatitis C virus (HCV) virions are associated with triglyceride-rich lipoproteins, including very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), designated as lipo-viro-particles (LVPs). (bmj.com)
- Previous studies showed that lipoprotein lipase (LPL), a key enzyme for hydrolysing the triglyceride in VLDL to finally become LDL, may suppress HCV infection. (bmj.com)
- In vitro, EL is capable of hydrolyzing very-low-density lipoprotein (VLDL) TG and PL. 8 Moderate transgenic overexpression of EL does not affect LpB levels, 18 but adenoviral-mediated overexpression of EL in mice reduces LpB levels. (ahajournals.org)
- Particles with reduced electrophoretic mobility appear in very low density lipoprotein (VLDL). (ox.ac.uk)
- Absence of the enzyme did not affect the rate at which large very low density lipoproteins were converted to smaller particles within this density interval (i.e., of VLDL). (ox.ac.uk)
- However, subsequent transfer of small very low density lipoproteins to intermediate density particles was retarded by 50%, explaining the abnormal accumulation of VLDL in the patient's plasma. (ox.ac.uk)
Polymorphism1
- Background: In recent years, the lipoprotein lipase (LPL) polymorphism has been extensively investigated as a potential risk factor for coronary artery disease (CAD). (mdpi.com)
Particles8
- tg rich lipoprotein particles. (healthtap.com)
- Transformation of high density lipoprotein 2 particles by hepatic lipase and phospholipid transfer protein. (julkari.fi)
- A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. (biomedcentral.com)
- Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). (sdsc.edu)
- Associates with lipoprotein particles in blood plasma (PubMed:11342582, PubMed:11893776). (sdsc.edu)
- Despite this, intermediate density particles accumulated to a level 2.4-times normal because their subsequent conversion to low density lipoprotein has been almost totally inhibited. (ox.ac.uk)
- On the basis of these observations, hepatic lipase appears to be essential for the conversion of small very low density and intermediate density particles to low density lipoproteins. (ox.ac.uk)
- Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules around the body within the water outside cells. (natrilha.info)
Adipose tissue lipoprotein lipase activity2
- 1. Alloxan-diabetic rats showed raised plasma triglyceride levels and low adipose tissue lipoprotein lipase activity compared with controls. (clinsci.org)
- Obese subjects have elevated adipose tissue lipoprotein lipase activity per fat cell when compared with lean control subjects. (natrilha.info)
Protein10
- After secretion, LPL is carried across endothelial cells and presented into the capillary lumen by the protein glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. (wikipedia.org)
- Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), a newly identified factor, appears essential for transporting LPL to the luminal side of the blood vessel and offering a platform for TG hydrolysis. (nih.gov)
- Recombinant protein fragment corresponding to amino acids 28-475 of human Lipoprotein Lipase/LPL (NP_000228) produced in HEK293T. (fishersci.com)
- Hearts of transgenic mice expressed the altered lipoprotein lipase, and the protein localized to the surface of cardiomyocytes. (jci.org)
- Here, we investigated the effects of PPAR alpha and CP on expression and enzyme activity of kidney lipoprotein lipase (LPL) as well as on expression of angiopoietin protein-like 4 (Angptl4), glycosylphosphatidylinositol-anchored-HDL-binding protein (GPIHBP1), and lipase maturation factor 1 (Lmf1), which are recognized as important proteins that modulate LPL activity. (diva-portal.org)
- Lipoprotein lipase is a multifunctional protein, playing a major role in the hydrolysis of TG-rich lipoproteins. (ahajournals.org)
- 2. We have therefore, studied 18 patients with diabetes mellitus, obesity and severe hypertriglyceridaemia for defects of a key protein involved in the clearance of plasma triacylglycerols, lipoprotein lipase. (clinsci.org)
- The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. (escholarship.org)
- GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen. (escholarship.org)
- Lipase is a protein (enzyme) released by the pancreas into the small intestine. (adam.com)
Density17
- 17 In a more recent study, Fisher et al showed that LPL D9N causes enhanced low-density lipoprotein (LDL) binding and monocyte adhesion compared with LPL WT and was thus suggested to enhance foam cell formation in the vascular wall. (ahajournals.org)
- The trypsin-treated LPL retained the ability to bind to very density lipoproteins. (nii.ac.jp)
- LPL-S132N showed no activity against triolein or tributyrin, whereas the mutant LPL bound to very low density lipoproteins as effectively as wild type LPL. (nii.ac.jp)
- and high density lipoproteins (HDL). (thefreedictionary.com)
- high density lipoproteins which migrate in the alpha position in paper chromatography. (thefreedictionary.com)
- It is possible that these apoproteins function partly to modulate the hydrolysis of very low density lipoprotein triglyceride by lipoprotein lipase. (ahajournals.org)
- The oxidation of low-density lipoprotein (LDL) is thought to contribute to atherogenesis. (garvan.org.au)
- 4. The activity was strongly stimulated by trout very low density lipoproteins and to a lesser extent by high density lipoproteins. (biochemj.org)
- Most notably, the HL/EL-dko mice exhibited an unexpected substantial increase in small low-density lipoproteins. (ahajournals.org)
- Kinetic studies with [ 3 H]cholesteryl ether-labeled very-low-density lipoproteins demonstrated that the HL/EL-dko mice accumulated counts in the smallest low-density lipoprotein-sized fractions, as assessed by size exclusion chromatography, suggesting that it arises from lipolysis of very-low-density lipoproteins. (ahajournals.org)
- in contrast, HL-knockout (ko) mice fed a high-fat diet exhibit a modest increase in plasma LpB levels, 17 which is exacerbated in the absence of apoE 27 or the low-density lipoprotein (LDL) receptor. (ahajournals.org)
- Low density lipoprotein (LDL) isolated from th LHPO group exhibited high TBA values about 6 times the control LDL. (nii.ac.jp)
- As a result of which the balance between the fat deposition and clearing is disturbed in the arterial walls giving rise to more and more deposition of a type of fat called as Low Density Lipoprotein giving rise to atherosclerosis resulting in CAD and Stroke. (edoctoronline.com)
- Intermediate density lipoprotein (IDL) increases markedly in the circulation and plasma low density lipoprotein (LDL) levels fall. (ox.ac.uk)
- At the same time there is a mass redistribution within the high density lipoprotein (HDL) spectrum leading to dominance in the less dense HDL2 subfraction. (ox.ac.uk)
- Consequently, the plasma concentration of low density lipoprotein was only 10% of normal. (ox.ac.uk)
- High- density lipoproteins ( HDL) are one of the five major groups of lipoproteins. (natrilha.info)
Insulin11
- In all of the family members (parents, two affected sisters, ages 18 and 15 years, and an 11-year-old unaffected sister), we measured oral glucose tolerance, insulin sensitivity (by the euglycemic-hyperinsulinemic clamp technique), substrate oxidation (indirect calorimetry), endogenous glucose production (by the [6,6-2H2]glucose technique), and postheparin plasma lipoprotein lipase (LPL) activity. (diabetesjournals.org)
- Insulin and lipoprotein lipase work together in your body to use extra calories from carbohydrates in your diet to make and store fats. (sfgate.com)
- Insulin stimulates lipoprotein lipase production, especially in your fatty tissues. (sfgate.com)
- http://healthyeating.sfgate.com/lipoprotein-lipase-insulin-6065.html. (sfgate.com)
- Lipoprotein Lipase & Insulin" last modified December 27, 2018. (sfgate.com)
- Amylase, lipase and insulin blood test? (healthtap.com)
- Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues," Diabetes , vol. 58, no. 1, pp. 116-124, 2009. (hindawi.com)
- Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase. (semanticscholar.org)
- Lipoprotein lipase in mouse peritoneal macrophages: the effects of insulin and dexamethasone. (mysciencework.com)
- The effects of insulin and dexamethasone on the secretion of lipoprotein lipase (LPL) by mouse peritoneal macrophages were examined in vitro. (mysciencework.com)
- Compared to sedentary controls, exercise decreased plasma insulin, epididymal and retroperitoneal depot weight and cell size, and retroperitoneal lipoprotein lipase (LPL) activity. (elsevier.com)
Post-heparin1
- Selective measurement of two lipase activities in post heparin plasma from normal subjects and patients with hyperlipoproteinemia. (nii.ac.jp)
Pancreatic1
- Yes research has suggested that fluorinated water may be responsible for the decreased activity of both pancreatic lipase protease. (natrilha.info)
Lipolytic5
- GPIHBP1 complex is responsible for margination of triglyceride-rich lipoproteins along capillaries and their lipolytic processing. (escholarship.org)
- Little is known about the fate of the lipolytic products produced by the action of lipoprotein lipase (LPL) on circulating triglyceride-rich lipoproteins in humans. (elsevier.com)
- These results indicate that there is escape, or spillover, of the lipolytic products of LPL action on triglyceride-rich lipoproteins in humans. (elsevier.com)
- Adipose triglyceride lipase and the lipolytic catabolism of cellular fat. (natrilha.info)
- Lipoprotein Lipase has both lipolytic and sterol ester hydrolytic activities. (roche.com)
Free fatty2
- These findings indicate that increased values of lipoprotein lipase and free fatty acids in the milk are not responsible for the development of breast-milk jaundice. (nih.gov)
- Lipoprotein lipase (LPL) serves as a central factor in hydrolysis of triacylglycerol and uptake of free fatty acids from the plasma. (mdpi.com)
Antibody2
- Lipoprotein Lipase/LPL Monoclonal antibody specifically detects Lipoprotein Lipase/LPL in Human samples. (fishersci.com)
- There are currently no images for Lipoprotein Lipase/LPL Antibody Pair (H00004023-PW1). (novusbio.com)
Regulation2
- This investigation considers the regulation of LPL by lipoproteins and LVPs, and their roles in the LPL-mediated anti-HCV function. (bmj.com)
- Regulation of Lipolysis and Lipoprotein Lipase after Weight Loss in. (natrilha.info)
Activity Assay Kit1
- The Lipoprotein Lipase ( LPL ) Activity Assay Kit is a simple, fluorometric assay that quantitatively measures LPL activity in plasma, serum, and lysates in a 96-well microtiter plate format. (cellbiolabs.com)
Genetic1
- 5. We conclude that genetic variants at the lipoprotein lipase locus occur commonly in subjects with this syndrome (four out of 18 subjects with probably functional mutants) and may affect the individual's response to obesity and diabetes mellitus for the development of lipaemia. (clinsci.org)
Atherosclerosis3
- R. J. Brown and D. J. Rader, "Lipases as modulators of atherosclerosis in murine models," Current Drug Targets , vol. 8, no. 12, pp. 1307-1319, 2007. (hindawi.com)
- Lipoprotein lipase for treating Atherosclerosis. (edoctoronline.com)
- Atherosclerosis is a disease process due to increased fat level in blood called as lipoproteins resulting deposition of these fat in the wall of the blood vessels causing narrowing/obstruction of the lumen of the blood vessels, as a result of which blood flow is compromised to the various organs of the body. (edoctoronline.com)
Capillary endothelial cells1
- It is concluded that plasma glycerides are hydrolyzed by lipoprotein lipase in capillary endothelial cells and in the subendothelial space of adipose tissue and that glycerides across the endothelial cells within a membrane-bounded system. (rupress.org)
Inhibition2
- Addition of apoC-III reduced the initial rate of hydrolysis by LPL, but the inhibition became less prominent with time when the lipoproteins were triglyceride poor. (diva-portal.org)
- The inhibition of lipoprotein lipase increased as the concentration of the extracts increased. (noniresearch.org)
Humans1
- Zheng, C.et al : Lipoprotein lipase bound to apoB lipoproteins accelerates clearance of postprandial lipoproteins in humans. (immuquest.com)
Cardiovascular disease1
- Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. (baptistjax.com)
Skeletal muscle1
- Skeletal muscle lipoprotein lipase activity in CON, EX-DEF and EX-BAL. (biomedcentral.com)
Uptake3
- LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. (wikipedia.org)
- Thus, lipoprotein lipase expressed on the surface of cardiomyocytes can increase lipid uptake and produce cardiomyopathy. (jci.org)
- Lipoprotein lipase (LPL), the primary enzyme responsible for tissue uptake of triglyceride fatty acids, may strongly influence both maternal milk fat secretion and pup blubber deposition. (springer.com)
Monoclonal1
- Peterson, J.et al: Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies. (immuquest.com)
Postprandial1
- The extent and duration of this postprandial response is regulated by lipoprotein lipase (LPL). (surrey.ac.uk)
Plasma4
- Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). (abcam.com)
- Hearts, but not postheparin plasma, of these mice contained human lipoprotein lipase activity. (jci.org)
- 1. Intravenous injection of heparin into the trout resulted in the appearance in the plasma of a lipase with the properties of lipoprotein lipase. (biochemj.org)
- In vitro studies were performed by adding purified hepatic lipase to the patient's plasma. (ox.ac.uk)
Enzyme activity1
- Extracts of intact adipose tissue separated into two major lipoprotein lipase activity peaks, designated "a" and "b", the "a" fraction representing about 30 (fasted rats) to 50% (fed rats) of the total enzyme activity. (lu.se)
Bovine1
- Purified human and bovine recombinant Lipoprotein lipase. (abcam.com)