Linoleic Acids, Conjugated
Fatty Acids, Unsaturated
Fatty Acids, Essential
Fatty Acid Desaturases
Fatty Acids, Omega-6
Fatty Acids, Omega-3
Gas Chromatography-Mass Spectrometry
Fatty Acids, Nonesterified
Chromatography, Thin Layer
Trans Fatty Acids
Chromatography, High Pressure Liquid
Dioctyl Sulfosuccinic Acid
Peroxisome Proliferator-Activated Receptors
Dose-Response Relationship, Drug
Carbon-Carbon Double Bond Isomerases
Unsaturated fatty acid requirements for growth and survival of a rat mammary tumor cell line. (1/1038)A cell line, the growth and survival of which is markedly affected by linoleic acid, has been established from a carcinogen-induced rat mammary tumor. The cells have been continuously passaged in 5% rat serum plus 10% fetal calf serum-supplemented medium. The rat serum component was found to be indispensalbe, for when it was omitted the growth rate rapidly declined and the cells died by 5 to 7 days. Removal of the rat serum from the growth medium also resulted in a dramatic loss of Oil Red O-positive droplets in the cells, suggesting that the lipid component of rat serum might be a major growth-promoting principle in rat serum. This is likely since the total lipid fraction, but not the delipidized protein fraction, could largely supplant requirement of the cells for rat serum. Pure linoleic acid was found to be effective in maintaining the cell growth in delipidized serum or in whole fetal calf serum-supplemented medium. Fatty acid analysis revealed a 19-fold higher amount of linoleic acid in rat serum than in fetal calf serum. (+info)
Dietary control of triglyceride and phospholipid synthesis in rat liver slices. (2/1038)1. The effect of dietary manipulation on the synthesis of triglycerides and phospholipids was investigated by determining the incorporation of labeled long-chain fatty acid or glycerol into these lipids in liver slices derived from normally fed, fasted, and fat-free refed rats. 2. Triglyceride synthesis was affected markedly by the dietary regime of the animal; the lowest rates were measured with fasted rats, and the highest ones with fat-free refed rats. 3. In contrast to triglyceride synthesis, phospholipid synthesis occured at virtually constant rates regardless of the dietary conditions. 4. Addition of large amounts of fatty acid to the incubation mixture resulted in a marked stimulation of triglyceride synthesis, whereas phospholipid synthesis was affected to a much smaller extent. 5. These results indicate that the synthesis of triglycerides and that of phospholipids are controlled independently, and that the availability of fatty acid in the cell contributes to the control of triglyceride synthesis. (+info)
13-(S)-hydroxyoctadecadienoic acid (13-HODE) incorporation and conversion to novel products by endothelial cells. (3/1038)13(S)-Hydroxy-[12,13-3H]octadecadienoic acid (13-HODE), a linoleic acid oxidation product that has vasoactive properties, was rapidly taken up by bovine aortic endothelial cells. Most of the 13-HODE was incorporated into phosphatidylcholine, and 80% was present in the sn -2 position. The amount of 13-HODE retained in the cells gradually decreased, and radiolabeled metabolites with shorter reverse-phase high-performance liquid chromatography retention times (RT) than 13-HODE accumulated in the extracellular fluid. The three major metabolites were identified by gas chromatography combined with mass spectrometry as 11-hydroxyhexadecadienoic acid (11-OH-16:2), 9-hydroxytetradecadienoic acid (9-OH-14:2), and 7-hydroxydodecadienoic acid (7-OH-12:2). Most of the radioactivity contained in the cell lipids remained as 13-HODE. However, some 11-OH-16:2 and several unidentified products with longer RT than 13-HODE were detected in the cell lipids. Normal human skin fibroblasts also converted 13-HODE to the three major chain-shortened metabolites, but Zellweger syndrome fibroblasts produced only a very small amount of 11-OH-16:2. Therefore, the chain-shortened products probably are formed primarily by peroxisomal beta-oxidation. These findings suggest that peroxisomal beta-oxidation may constitute a mechanism for the inactivation and removal of 13-HODE from the vascular wall. Because this is a gradual process, some 13-HODE that is initially incorporated remains in endothelial phospholipids, especially phosphatidylcholine. This may be the cause of some of the functional perturbations produced by 13-HODE in the vascular wall. (+info)
Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. (4/1038)The protective effect of flavonoids against linoleic acid hydroperoxide (LOOH)-induced cytotoxicity was examined by using cultured endothelial cells. When the cells were incubated with both LOOH and flavonoids, most flavonols protected the cells from injury by LOOH. Flavones bearing an ortho-dihydroxy structure also showed a protective effect against the cytotoxicity of LOOH. However, flavanones had no effect. The structure-activity relationship revealed the presence of either the ortho-di-hydroxy structure in the B ring of the flavonoids or 3-hydroxyl and 4-oxo groups in the C ring to be important for the protective activities. The interaction between flavonoids and a-tocopherol was also examined in this system. Flavonoids that were protective against LOOH-induced cytotoxicity had at least an additive effect on the action of alpha-tocopherol against LOOH-induced damage. (+info)
Uptake of 13-hydroperoxylinoleic acid by cultured cells. (5/1038)Oxidized free fatty acids have profound effects on cultured cells. However, little is known about whether these effects depend on their uptake and metabolism by cells or primarily involve their interaction with cell-surface components. We determined the uptake and metabolism of unoxidized (linoleic or oleic acid) and oxidized linoleic acid (13-hydroperoxyoctadecadienoic acid, 13-HPODE) by endothelial cells, smooth muscle cells, and macrophages. We show that 13-HPODE is poorly taken up by cells. The levels of uptake were dependent on the cell type but were independent of the expression of CD36. 13-HPODE was also poorly used by microsomal lysophosphatidylcholine acyltransferase that is involved in the formation of phosphatidylcholine. Based on these results, we suggest that most of the biological effects of 13-HPODE and other oxidized free fatty acids on cells might involve a direct interaction with cell-surface components. Alternatively, very small amounts of oxidized free fatty acids that enter the cell may have effects, analogous to those of hormones or prostanoids. (+info)
Formation of 9-hydroxy linoleic acid as a product of phospholipid peroxidation in diabetic erythrocyte membranes. (6/1038)The increased production of oxygen-derived free radicals (OFR) and lipid peroxidation may contribute to vascular complications in diabetes. Some lipid peroxidation products have already been reported to be formed via glucose-induced oxidative stress. We have identified 9-hydroxy linoleic acid (9-OH-C18:2) in the red cell membrane phospholipid of diabetic subjects. We hypothesized that 9-OH-C18:2 would be formed in hydroxyl radical reactions to linoleic acid (C18:2) during glucose-induced oxidative stress, and confirmed that the formation of 9-OH-C18:2 was induced by ultraviolet (UV)-C irradiation to the synthetic C18:2. UV-C light generates highly reactive hydroxy radicals. C18:2 is confirmed to be the precursor of 9-OH-C18:2. To estimate the degree of oxidative damage to red cell membrane phospholipids, we developed a selective ion monitoring gas chromatography-mass spectrometric measurement for C18:2 and 9-OH-C18:2, following methanolysis of red cell membrane phospholipids. The relative peak height ratio of C18:2 to 9-OH-C18:2 (9-OH-C18:2/C18:2) was measured in phospholipid extracts of red cell membranes from healthy (n=29, 3.1+/-1.9%) and diabetic (n=27, 20. 9+/-16.1%) subjects. It was confirmed that 9-OH-C18:2/C18:2 is significantly (P<0.001) elevated in patients with diabetes. The measurement of 9-OH-C18:2/C18:2 in red cell membranes should be useful for assessing oxidative damage to membrane phospholipids in diabetes. (+info)
Antiplatelet effects of conjugated linoleic acid isomers. (7/1038)Conjugated diene isomers of linoleic acid (CLA) are normal constituents of certain foods and exhibit anticarcinogenic and antiatherogenic properties. In the present study, the effects of several CLA isomers on human platelet aggregation and arachidonic acid metabolism were examined. It was found that 9c,11t-CLA, 10t, 12c-CLA and 13-hydroxy-9c,11t-octadecadienoic acid (13-HODE) inhibited arachidonic acid- and collagen-induced platelet aggregation with I50s in the 5-7 microM range. The nonconjugated 9c, 12c-LA was about 300% and 50%, respectively, less potent an inhibitor with these aggregating agents. Using either thrombin or the calcium ionophore A23187 as aggregating agents, a CLA isomer mix was also found to be more inhibitory than 9c,12c-LA. The 9c,11t- and 10t,12c-CLA isomers as well as the CLA isomer mix inhibited formation of the proaggregatory cyclooxygenase-catalyzed product TXA2, as measured by decreased production of its inactive metabolite [14C]TXB2 from exogenously added [14C]arachidonic acid (I50s=9-16 microM). None of the CLA isomers tested inhibited production of the platelet lipoxygenase metabolite [14C]12-HETE. The additional presence of a hydroxyl group gave opposite results: 13-HODE (I50=3 microM) was about 4-fold more potent a cyclooxygenase inhibitor than the 9c,11t-CLA isomer but 9-HODE was 2- to 3-fold less effective an inhibitor (I50=34 microM) of [14C]TXB2 formation than the corresponding 10t,12c-CLA. In both the aggregation and arachidonic acid metabolism experiments, the inhibitory effects of CLA on platelets were reversible and dependent on the time of addition of either the aggregating agent or the [14C]arachidonic acid substrate. These studies suggest that CLA isomers may also possess antithrombotic properties. (+info)
Loss-of-function mutations in PPAR gamma associated with human colon cancer. (8/1038)The gamma isoform of the peroxisome proliferator-activated receptor, PPAR gamma, regulates adipocyte differentiation and has recently been shown to be expressed in neoplasia of the colon and other tissues. We have found four somatic PPAR gamma mutations among 55 sporadic colon cancers: one nonsense, one frameshift, and two missense mutations. Each greatly impaired the function of the protein. c.472delA results in deletion of the entire ligand binding domain. Q286P and K319X retain a total or partial ligand binding domain but lose the ability to activate transcription through a failure to bind to ligands. R288H showed a normal response to synthetic ligands but greatly decreased transcription and binding when exposed to natural ligands. These data indicate that colon cancer in humans is associated with loss-of-function mutations in PPAR gamma. (+info)
Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.
There are several ways to measure body weight, including:
1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.
It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.
1. Scurvy: A disease caused by a lack of vitamin C in the diet, leading to bleeding gums, weakened immune system, and poor wound healing.
2. Rickets: A disease that affects children and is caused by a lack of calcium and vitamin D, leading to soft and weak bones.
3. Anemia: A condition where the body does not have enough red blood cells or hemoglobin, which can be caused by a lack of iron, folate, or vitamin B12.
4. Beriberi: A condition that affects the heart and nervous system and is caused by a lack of vitamin B1 (thiamine), leading to muscle weakness, fatigue, and heart failure.
5. Goiter: An enlarged thyroid gland that can be caused by a lack of iodine in the diet, leading to hypothyroidism and other complications.
6. Pellagra: A disease caused by a lack of niacin (vitamin B3) in the diet, leading to diarrhea, dermatitis, and dementia.
7. Kwashiorkor: A condition that occurs in children who are malnourished due to a lack of protein in their diet, leading to edema, skin lesions, and diarrhea.
8. Marasmus: A severe form of malnutrition that can be caused by a lack of calories, protein, or other essential nutrients, leading to weight loss, wasting, and weakened immune system.
Deficiency diseases can be prevented by consuming a well-balanced diet that includes a variety of whole foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats. In some cases, deficiency diseases may also be treated with supplements or other medical interventions.
It is important to note that deficiency diseases can have far-reaching consequences for individuals, families, and communities. Malnutrition can lead to reduced productivity, increased healthcare costs, and a lower quality of life. Therefore, it is essential to prioritize nutrition and take steps to prevent deficiency diseases.
There are several different types of weight gain, including:
1. Clinical obesity: This is defined as a BMI of 30 or higher, and is typically associated with a range of serious health problems, such as heart disease, type 2 diabetes, and certain types of cancer.
2. Central obesity: This refers to excess fat around the waistline, which can increase the risk of health problems such as heart disease and type 2 diabetes.
3. Muscle gain: This occurs when an individual gains weight due to an increase in muscle mass, rather than fat. This type of weight gain is generally considered healthy and can improve overall fitness and athletic performance.
4. Fat gain: This occurs when an individual gains weight due to an increase in body fat, rather than muscle or bone density. Fat gain can increase the risk of health problems such as heart disease and type 2 diabetes.
Weight gain can be measured using a variety of methods, including:
1. Body mass index (BMI): This is a widely used measure of weight gain that compares an individual's weight to their height. A BMI of 18.5-24.9 is considered normal, while a BMI of 25-29.9 is considered overweight, and a BMI of 30 or higher is considered obese.
2. Waist circumference: This measures the distance around an individual's waistline and can be used to assess central obesity.
3. Skinfold measurements: These involve measuring the thickness of fat at specific points on the body, such as the abdomen or thighs.
4. Dual-energy X-ray absorptiometry (DXA): This is a non-invasive test that uses X-rays to measure bone density and body composition.
5. Bioelectrical impedance analysis (BIA): This is a non-invasive test that uses electrical impulses to measure body fat percentage and other physiological parameters.
Causes of weight gain:
1. Poor diet: Consuming high amounts of processed foods, sugar, and saturated fats can lead to weight gain.
2. Lack of physical activity: Engaging in regular exercise can help burn calories and maintain a healthy weight.
3. Genetics: An individual's genetic makeup can affect their metabolism and body composition, making them more prone to weight gain.
4. Hormonal imbalances: Imbalances in hormones such as insulin, thyroid, and cortisol can contribute to weight gain.
5. Medications: Certain medications, such as steroids and antidepressants, can cause weight gain as a side effect.
6. Sleep deprivation: Lack of sleep can disrupt hormones that regulate appetite and metabolism, leading to weight gain.
7. Stress: Chronic stress can lead to emotional eating and weight gain.
8. Age: Metabolism slows down with age, making it more difficult to maintain a healthy weight.
9. Medical conditions: Certain medical conditions such as hypothyroidism, Cushing's syndrome, and polycystic ovary syndrome (PCOS) can also contribute to weight gain.
Treatment options for obesity:
1. Lifestyle modifications: A combination of diet, exercise, and stress management techniques can help individuals achieve and maintain a healthy weight.
2. Medications: Prescription medications such as orlistat, phentermine-topiramate, and liraglutide can aid in weight loss.
3. Bariatric surgery: Surgical procedures such as gastric bypass surgery and sleeve gastrectomy can be effective for severe obesity.
4. Behavioral therapy: Cognitive-behavioral therapy (CBT) and other forms of counseling can help individuals develop healthy eating habits and improve their physical activity levels.
5. Meal replacement plans: Meal replacement plans such as Medifast can provide individuals with a structured diet that is high in protein, fiber, and vitamins, and low in calories and sugar.
6. Weight loss supplements: Supplements such as green tea extract, garcinia cambogia, and forskolin can help boost weight loss efforts.
7. Portion control: Using smaller plates and measuring cups can help individuals regulate their portion sizes and maintain a healthy weight.
8. Mindful eating: Paying attention to hunger and fullness cues, eating slowly, and savoring food can help individuals develop healthy eating habits.
9. Physical activity: Engaging in regular physical activity such as walking, running, swimming, or cycling can help individuals burn calories and maintain a healthy weight.
It's important to note that there is no one-size-fits-all approach to treating obesity, and the most effective treatment plan will depend on the individual's specific needs and circumstances. Consulting with a healthcare professional such as a registered dietitian or a physician can help individuals develop a personalized treatment plan that is safe and effective.
Conjugated linoleic acid
Di-deuterated linoleic acid ethyl ester
Essential fatty acid interactions
Phospholipid-derived fatty acids
Delta12-fatty acid dehydrogenase
Essential fatty acid
List of vegetable oils
Tea seed oil
Conjugated fatty acid
Fatty acid desaturase
Linoleate diol synthase
Buffalo gourd oil
Kalahari melon oil
Divinylether fatty acids
Conjugated Linoleic Acid CLA Supplements Helpful For Obesity
Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells
Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake...
View of Calcium and linoleic acid supplements in the prevention of pre-eclampsia.
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Conjugated linoleic acid (CLA) - dairy products - human health. 2. CLA in dairy products and different foods
Metadatos: Effect of conjugated linoleic acid on non enzymatic lipid peroxidation of mitochondria obtained from different rat...
IMSEAR at SEARO: Linoleic acid hemolysis of erythrocytes.
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Isomerized linoleic acid | Spýtajte sa.NAOS
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Direct effects of conjugated linoleic acid isomers on P815 mast cells in vitro. | Immunol Invest;41(4): 399-411, 2012. |...
Conjugated Linoleic Acid and Atherosclerosis - Amazing Collection of Nutrition
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California Gold Nutrition, CLA, Conjugated Linoleic Acid, 1,000 mg, 90
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies | Nature Communications
The benefits of CLA-1000 (Conjugated Linoleic Acid) - Ann Louise Gittleman
PM Therapy | Moisturizers with Hyaluronic Acid & Vitamins | EltaMD®
CLA PRO : Conjugated linoleic acid, or CLA is part of the omega-6
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Sci.chem FAQ - Part 1 of 7
- Dietary CLA refers to a group of isomers of derivatives of linoleic acid. (mercola.com)
- Conjugated linoleic acid (CLA) refers to a group of naturally occurring positional and geometrical conjugated dienoic isomers of linoleic acid (C18:2), of which the cis-9,trans-11 (c9,t11) and trans-10,cis-12 (t10,c12) isomers predominate. (spandidos-publications.com)
- Conjugated linoleic acids (CLA) are conjugated isomers of linoleic acid, which may promote health with regard to cancer, heart disease, diabetes, bone formation, growth modulation and immunity. (nih.gov)
- Conjugated linoleic acids (CLAs) are positional and geometrical isomers of linoleic acid and some researchers have shown biological activities including modulation of lipid metabolism, atherogenesis, diabetes, and immune functions. (ajol.info)
- The location of the first double bond from the omega end dictates whether a fatty acid is an omega-3, omega-6, omega-9 (oleic acid) or another member of the omega family. (globalresearch.ca)
- Research has found that including oleic and linoleic acid in hair care products helps the scalp absorb other ingredients faster and more efficiently," she says. (wellandgood.com)
- Did you mean Ascorbic Acid OR Chia Seed Oil OR Doconexent OR Linoleic Acid OR linoleic Acid OR Oleic Acid OR Sodium OR Sucrose ? (nih.gov)
- Delta 12-desaturases catalyse the biosynthesis of linoleic acid by introducing a second double bond into oleic acid, but have been identified in only a fewanimal species. (uni-regensburg.de)
- Male rats and rats with type 1 diabetes administered streptozocin were orally administered LA, trilinolein, α- linolenic acid (α-LA), oleic acid , TAK-875, or TUG-891 immediately before glucose load. (bvsalud.org)
- Pretreatment with AH7614, a GPR120 antagonist, partially canceled the improvement of postprandial hyperglycemia induced by LA. α-LA, which has high affinity with GPR120 as well as LA, slowed the elevation of postprandial blood glucose levels, but oleic acid , which has lower affinity with GPR120 than LA, did not. (bvsalud.org)
- For example, it was found that the oil on the faces of those with acne-prone skin produces less linoleic acid and more oleic. (glowsly.com)
- Oils rich in linoleic acid normally have a much shorter shelf life than other oils, which is why you can't use any old oil found in the grocery store - they are often processed in some way in order to increase their oleic acid content and reduce their linoleic acid content. (glowsly.com)
- EPO consists of a variety of essential fatty acids, including -linolenic acid (GLA), linoleic acid (LA), oleic acid, palmitic acid, and stearic acid. (nih.gov)
- A conjugated linoleic acid supplement can be a great way to support a healthy body weight. (earthturns.com)
- Many people use conjugated linoleic acid supplements to support metabolism , and it may also be beneficial to the cardiovascular system. (earthturns.com)
- Lui O, Mak N and Leung K: Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells. (spandidos-publications.com)
- Conjugated linoleic acid (CLA) - dairy products - human health. (fao.org)
- The polyunsaturated fatty acid composition, chemiluminescence and peroxidizability index of mitochondria obtained from rat liver, kidney, lung and heart, were studied after oral administration of conjugated linoleic acid (CLA). (siu.edu.ar)
- Conjugated linoleic acid and fatty acid binding protein as antioxidants por: Piergiacomi, V.A., et al. (siu.edu.ar)
- Background: Conjugated linoleic acid (CLA), a naturally occurring compound found in ruminants products, has been shown to possess anticancer properties in vivo and in vitro. (iiarjournals.org)
- When dairy cows have access to pastures or green fodder, they ingest linoleic acid, among other things, which can be converted into conjugated linoleic acid in the rumen. (basf.com)
- This is why milk from grass-fed cows usually contains more conjugated linoleic acid (CLA) than milk from cows that have no access to pastures or green fodder. (basf.com)
- A quick screening methodology was developed to isolate existing lactic acid bacteria from dairy products and determine compatible carbon and nitrogen sources using Phenotypic screening for production of conjugated linoleic acid. (journalcra.com)
- The microorganisms were able to produce conjugated linoleic acid from castor oil hydrolysate in MRS broth and also in fat rich milk during fermentation under the given experimental conditions. (journalcra.com)
- The conjugated linoleic acid profiles and contents were determined and compared with Lactobacillus delbrueckii. (journalcra.com)
- CLA, offered by Douglas Laboratories®, provide a significant amount of conjugated linoleic acid, together with an extract of green tea for maximum stabilization. (drguberman.com)
- CLA also known as conjugated linoleic acid is a rising star in the weight loss and sports nutrition industries. (revivgreen.com)
- To determine effects of conjugated linoleic acid (CLA) on establishment and progression of experimentally-induced atherosclerosis in rabbits. (am-coll-nutr.org)
- This potent nutrient is called conjugated linoleic acid or CLA, found in raw dairy or grass-fed beef. (ezhealthsolutions.com)
- Conjugated linoleic acid (CLA) is a naturally-occurring polyunsaturated fatty acid that is most commonly found in beef and dairy, but our supplement uses a plant-based option from safflower oil. (californiagoldnutrition.com)
- California Gold Nutrition CLA contains Clarinol® Conjugated Linoleic Acid (CLA) derived from safflower oil in convenient softgels. (californiagoldnutrition.com)
- 2. Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8(+) lymphocytes. (nih.gov)
- The end of the fatty acid chain that is opposite the acid end is the "omega end. (globalresearch.ca)
- Simultaneously, 3-d food duplicates (FD) were collected to determine analytically individual fatty acid intakes, including those of total CLA and RA. (nih.gov)
- Linoleic acid is an essential omega-6 fatty acid known as "vitamin F, for 'fat,'" says SkinSpirit physician Linne Linder, ND . (wellandgood.com)
- Because this fatty acid is an anti-inflammatory agent, it is good for alleviating acne," says Dr. Linder. (wellandgood.com)
- Insect pheromones are often derived from fatty acid metabolism. (uni-regensburg.de)
- Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial for the biosynthesis of these chemical signals. (uni-regensburg.de)
- Linoleic acid is an essential fatty acid involved in the human diet. (medicom-publishers.com)
- Fatty acids are a major nutrient in dietary fat , some of which are ligands of long-chain fatty acid receptors, including G-protein-coupled receptor (GPR) 40 and GPR120. (bvsalud.org)
- You don't hear a lot about linoleic acid for skin, but this essential fatty acid certainly deserves a serious mention. (glowsly.com)
- Linoleic acid is an essential fatty acid that occurs naturally in all kinds of oils, including sunflower oil, safflower oil, and grape seed oil. (glowsly.com)
- It is a type of polyunsaturated omega 6 fatty acid. (glowsly.com)
- When it's in an oil, linoleic acid is bound to glycerin , which means that the skin doesn't process it the same way as it would when it's just the isolated fatty acid on its own. (glowsly.com)
- Dr. Crabb stated that studies in 1970s showed that ethanol itself can cause fatty liver by inhibition of fatty acid oxidation, and that stimulation of fatty acid synthesis induces lipogenic enzymes. (nih.gov)
- Linoleic acid is a polyunsaturated fatty acid commonly derived in the American diet from corn, soybean, and other similar oils, as well as some nuts and seeds. (nih.gov)
- Ramsden and his team specialize in the study of lipids - fatty acid compounds found in many natural oils - and their role in aging, especially chronic pain and neurodegenerative conditions. (nih.gov)
- However, most dietary CLA in humans is obtained from dairy products, accounting for the cis-9,trans-11 CLA isomer, also known as rumenic acid, for more than 90% of the total CLA intake. (nih.gov)
- Dietary polyunsaturated fatty acids (PUFA) and inflammatory proteins associate with immune activation and have been implicated in the pathophysiology of mood disorders. (nih.gov)
- The invention provides methods of using dihydroxy unsaturated fatty acids as markers for identifying patients with a disorder associated with abnormal regulation of the cytochrome P450 metabolism or oxidation of unsaturated fatty acids. (nih.gov)
- As a consequence, the peroxidizability index -a parameter based on the maximal rate of oxidation of fatty acids- showed significant changes in liver and kidney mitochondria. (siu.edu.ar)
- Safflower oil, with around 75% linoleic acid, is very similar to sunflower oil. (glowsly.com)
- Acneic skin is typically associated with l ow levels of linoleic acid , and adding the ingredient into your routine topically can help clear things up. (wellandgood.com)
- Once consumed and processed by our body, linoleic acid comes to make up part of our sebum (the oil that human skin produces), but it can also reach our skin topically. (glowsly.com)
- The c9,t11 isomer of CLA, rumenic acid (RA), is the major isomer present in the diet. (nih.gov)
- What's great about linoleic acid is that it plays nicely with other ingredients, and can be used alongside more intense actives to help keep your skin calm. (wellandgood.com)
- I advise you to incorporate it into your skincare regimen since it helps to alleviate dryness and irritation that we can experience from more aggressive ingredients, like retinoids, AHAs, and glycolic acid," says Dr. Ciraldo. (wellandgood.com)
- As an oil component linoleic acid has emollient properties, meaning that it fills in the gaps between dead skin cells on the top levels of the skin, making the skin feel smoother, softer, and more supple. (glowsly.com)
- 1998. Interaction of blood lead and *-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. (cdc.gov)
- We'll help you find out which oils contain linoleic acid in remarkable quantities, and then will make sure you know how to use it once you add it to your routine. (glowsly.com)
- Oral administration of linoleic acid immediately before glucose load ameliorates postprandial hyperglycemia. (bvsalud.org)
- This study examined whether oral administration of linoleic acid (LA), a GPR40 and GPR120 agonist, immediately before glucose load would affect the elevation of postprandial blood glucose levels in rats . (bvsalud.org)
- In addition to that, all of the natural oils rich in linoleic acid contain other fabulous components that can help the skin, like anti-aging vitamins and phytosterols. (glowsly.com)
- Rosehip oil has 54% linoleic acid, but it is also rich in skin-rejuvenating and brightening vitamin A. (glowsly.com)
- The team's previous smaller studies explored if linoleic acid inflamed migraine-related pain processing tissues and pathways in the trigeminal nerve, the largest and most complex of the body's 12 cranial nerves. (nih.gov)
- They found that a diet lower in linoleic acid and higher in levels of omega-3 fatty acids (like those found in fish and shellfish) could soothe this pain pathway inflammation. (nih.gov)
- What distinguishes one fat from another is the specific combination of fatty acids it's composed of, and the properties of fats and fatty acids depend on their hydrogen saturation and the length of their molecules, also referred to as "chain length. (globalresearch.ca)
- U. rufipes males produce an isoprenoid sex pheromone in the same gland and do not depend on linoleic acid for pheromone production. (uni-regensburg.de)
- Linoleic acid is thought to have some anti-inflammatory properties, which might be why it helps to reduce acne which is an inflammatory condition. (glowsly.com)
- There are many plant oils that contain large amounts of linoleic acid, but I wanted to list the ones that show up the most frequently in skin care. (glowsly.com)
- The most pernicious toxin in the modern diet, and the fat you need to minimize consumption of, is the omega-6 fat linoleic acid (LA). LA makes up 60% to 80% of omega-6 fats and is the primary contributor to chronic disease. (globalresearch.ca)
- Hence, insects have developed a way to produce linoleic acid independent of the omega desaturase subfamily which harbours all of the eukaryotic Delta 12-desaturases known so far. (uni-regensburg.de)
- The human body cannot synthesize linoleic acid on its own, but it is an important part of our diet. (glowsly.com)
- Another study found that linoleic acid promotes hair growth by enhancing how hair follicles work and extending their life cycles so that they're able to grow more hair. (wellandgood.com)
- Oils rich in linoleic acid are especially popular in skin care because they have all kinds of fantastic properties that make all skin types function better. (glowsly.com)
- Additionally, many people who use oils rich in linoleic acid report that it helps reduce their breakouts. (glowsly.com)
- Which Oils Contain Linoleic Acid? (glowsly.com)
- Despite that, people with sensitive and acne-prone skin find that their skin tends to respond beautifully to oils high in linoleic acid, so I suspect that it still has an effect. (glowsly.com)
- One group received meals that had high levels of fatty fish or oils from fatty fish and lowered linoleic acid. (nih.gov)
- There are two basic types of fatty acids, based on how many of their carbon bonds are paired with hydrogen: saturated fats and unsaturated fats. (globalresearch.ca)
- Three isolates were selected from different dairy products based on their acid production potential when grown on sugar sources and/or fatty acids. (journalcra.com)
- A Mendelian randomisation study provided evidence for an inverse causal association of circulating linoleic acid levels with risk of ischaemic stroke, particularly large artery stroke. (medicom-publishers.com)
- Epidemiological studies have suggested an inverse association between circulating linoleic acid levels and ischaemic stroke , but it was unclear whether the observed association is causal or due to confounding or reverse causation. (medicom-publishers.com)
- To evaluate the potential causal relationship between circulating linoleic acid levels and risk of ischaemic stroke, summary statistics for ischaemic stroke were obtained from the MEGASTROKE consortium . (medicom-publishers.com)
- First author Dr David Wu (University of Minnesota Medical School, MN, USA) explained that 17 single nucleotide polymorphisms (SNPs) associated with circulating linoleic acid levels were used as instrumental variables in the Mendelian randomisation analysis, with another 2 SNP sets used in sensitivity analyses. (medicom-publishers.com)
- We found an inverse causal relationship between circulating linoleic acid levels and ischaemic stroke overall, and especially in large artery stroke," Dr Wu said. (medicom-publishers.com)
- Every 1% increase in genetically predicted linoleic acid levels was inversely associated with a 2% reduction in ischaemic stroke incidence. (medicom-publishers.com)
- A second group received meals that had high levels of fatty fish and higher linoleic acid. (nih.gov)
- In this article, we'll explain exactly what linoleic acid is, and what it does to the skin. (glowsly.com)