Scaffolding proteins that play an important role in the localization and activation of 5-LIPOXYGENASE.
Compounds that bind to and inhibit the action of 5-LIPOXYGENASE-ACTIVATING PROTEINS.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
Transport proteins that carry specific substances in the blood or across cell membranes.
An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.
Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a corresponding reduction of another part of the same molecule. They include enzymes converting aldoses to ketoses (ALDOSE-KETOSE ISOMERASES), enzymes shifting a carbon-carbon double bond (CARBON-CARBON DOUBLE BOND ISOMERASES), and enzymes transposing S-S bonds (SULFUR-SULFUR BOND ISOMERASES). (From Enzyme Nomenclature, 1992) EC 5.3.
Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
Compounds in which one or more of the three hydroxyl groups of glycerol are in ethereal linkage with a saturated or unsaturated aliphatic alcohol; one or two of the hydroxyl groups of glycerol may be esterified. These compounds have been found in various animal tissue.
A group of alicyclic hydrocarbons with the general formula R-C5H9.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A factor identified in the brain that influences the growth and differentiation of NEURONS and NEUROGLIA. Glia maturation factor beta is the 17-kDa polypeptide product of the GMFB gene and is the principal component of GLIA MATURATION FACTOR.
Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
A cytokine produced by activated T-LYMPHOCYTES that stimulates the migration of CD4-POSITIVE LYMPHOCYTES and monocytes. It has been reported to suppress HIV replication.
Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.
"ALOX5 arachidonate 5-lipoxygenase [Homo sapiens (human)] - Gene - NCBI". Haeggström, J. Z.; Funk, C. D. (2011). "Lipoxygenase ... or Leukotriene C4 (LTC4) (LTC4 may be further metabolized to leukotriene D4 [LTD4] and then to Leukotriene E4 [LTE4]), or 3 ... Alox15b is as effective as ALOX5 in metabolizing 5-HpETE to leukotrienes. Alox12e (12-Lox-e, epidermal-type 12-Lox) is an ... Biosynthesis) while ALOX15 and possibly ALOX15B can act with ALOX5 to metabolize eicosapentaenoic acid to resolvin D's (see ...
See Leukotriene#Biosynthesis, Hydroxyeicosatetraenoic acid, and Eoxin#Human biosynthesis. The enzyme 5-lipoxygenase (5-LO or ... see arachidonate 5-lipoxygenase#Mead acid). Hydroxyeicosatetraenoic acids, leukotrienes, eoxins and prostanoids are sometimes ... Lipoxygenases (LOXs): 5-Lipoxygenase (5-LOX or ALOX5) initiates the metabolism of arachidonic acid to 5- ... Rådmark O, Werz O, Steinhilber D, Samuelsson B (2015). "5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and ...
Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ... Antileukotriene agents Arachidonate 5-lipoxygenase ALOX5-inhibiting drugs David L. Nelson, Michael M. Cox. Lehninger's ... 5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of ... Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase ( ...
Rådmark O, Werz O, Steinhilber D, Samuelsson B (2015). "5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and ... ALOX5 contributes to the formation of PUFA metabolites that may promote (e.g. the leukotrienes, 5-oxo-ETE) but also to ... Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It ...
... arachidonate 15-lipoxygenase 2, 15-lipoxygenase-2, 15-LOX-2, 15-LO-2, arachidonate 15-lipoxygenase type II, arachidonate 15- ... Claesson HE (September 2009). "On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation ... 12-Oxo-ETE, which along with 12S-HETE, activates the Leukotriene B4 receptor, Leukotriene B4 receptor 2 (BLT2) but not its ... 15S-HEPA inhibits ALOX5-dependent production of the pro-inflammatory mediator, LTB4, in cells, and may thereby serve an anti- ...
... leukotriene D4, and E4. Formation of the leukotrienes is initiated by 5-lipoxygenase metabolism of arachidonic acid to form a 5 ... Oxygenated by 5-lipoxygenase (ALOX5 to form its 5,6-trans epoxide derivative which may then rearrange to the lipoxins (LX), ... Claesson, H. E. (2009). "On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and ... "Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells". Journal ...
Rådmark O, Werz O, Steinhilber D, Samuelsson B (2015). "5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and ... ALOX5 contributes to the formation of PUFA metabolites that may promote (e.g. the leukotrienes, 5-oxo-ETE) but also to ... Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... ALOX5, Alox5, 5-LO, 5-LOX, 5LO, 5LX, AI850497, F730011J02, 5LPG, LOG5, arachidonate 5-lipoxygenase. ...
... arachidonate 5-lipoxygenase-activating protein) for IHC-P, WB. Anti-FLAP pAb (GTX89246) is tested in Human samples. 100% Ab- ... arachidonate 5-lipoxygenase-activating protein. Background. Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). ... Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. ... MK886binding protein, FLAP, arachidonate 5-lipoxygenase-activating protein, arachidonate5lipoxygenaseactivating, ...
... which encodes arachidonate 5-lipoxygenase, an integral enzyme in leukotriene biosynthesis. Leukotrienes are lipid mediators of ... ALOX5, arachidonate 5-lipoxygenase; eQTL, expression quantitative trait locus; FDR, false discovery rate; LTG, Laboratory of ... 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. Biochim Biophys Acta 2015;1851:331-9.doi: ... arachidonate 5-lipoxygenase; rs11239465: βTumour=−0.71, p=6.8×10−7; βNormal=0.52, p=3.8×10−4; figure 2A) and MYADML2 (myeloid- ...
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Gene Name:. ALOX5. ... 2. Arachidonate 5-lipoxygenase. General function:. Involved in metal ion binding. Specific function:. ... leukotriene D4 and leukotriene E4. The leukotrienes participate in host defense reactions and pathophysiological conditions ... Leukotriene A4, an unstable epoxide, is hydrolyzed to leukotriene B4 or conjugated with glutathione to yield leukotriene C4 and ...
ALOX5. Uniprot ID. P09917. Uniprot Name. Arachidonate 5-lipoxygenase. Molecular Weight. 77982.595 Da. ... Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.. Gene Name. ... and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with ... Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some ...
Arachidonate 5-Lipoxygenase Activating Protein, including: function, proteins, disorders, pathways, orthologs, and expression. ... Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and ... This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic ... arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved ...
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and ... This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic ... Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.. 26159646. 2015. Variants in the ... The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied.. ...
... arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has ... Six tag single nucleotide polymorphisms (SNPs)-ALOX5 rs12762303 and rs12264801, ALOX5AP rs10507391, LTA4H rs2072512, rs2540487 ... All genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly providing a ... a key enzyme in the biosynthesis of leukotrienes [10]. The LTA4H gene encodes leukotriene A4 hydrolase, a protein in the same ...
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and ... Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.. Gene Name:. ALOX5AP. Uniprot ID:. P20292 Molecular ... 5. Arachidonate 5-lipoxygenase-activating protein. General Function:. Protein n-terminus binding. Specific Function:. ... Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some ...
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and ... 6. Arachidonate 15-lipoxygenase. General function:. Involved in arachidonate 12-lipoxygenase activity. Specific function:. Non- ... Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).. Gene Name:. ALOX5AP. Uniprot ID:. ... Arachidonate 5-lipoxygenase-activating protein. General function:. Involved in arachidonic acid binding. Specific function:. ...
"ALOX5 arachidonate 5-lipoxygenase [Homo sapiens (human)] - Gene - NCBI". Haeggström, J. Z.; Funk, C. D. (2011). "Lipoxygenase ... or Leukotriene C4 (LTC4) (LTC4 may be further metabolized to leukotriene D4 [LTD4] and then to Leukotriene E4 [LTE4]), or 3 ... Alox15b is as effective as ALOX5 in metabolizing 5-HpETE to leukotrienes. Alox12e (12-Lox-e, epidermal-type 12-Lox) is an ... Biosynthesis) while ALOX15 and possibly ALOX15B can act with ALOX5 to metabolize eicosapentaenoic acid to resolvin Ds (see ...
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... The ALOX5 SNP rs1369214 is only 360 bp from rs2115819, while the ALOX5 SNP rs11239524 is ~11 kb from ALOX5 SNP rs2115819. The ... O. Rådmark, "Arachidonate 5-lipoxygenase," Prostaglandins and Other Lipid Mediators, vol. 68-69, pp. 211-234, 2002. View at ... An alternative pathway involves biosynthesis of proinflammatory leukotrienes (e.g., LTB4) by 5-LO (and 5-LO-activating protein ...
LTs are derived from arachidonic acid through action by arachidonate 5-lipoxygenase (ALOX5). Cysteinyl leukotrienes (LTC4, LTD4 ... On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma Claesson, ... and LTE4) are generated as products derived from leukotriene A4 (LTA4). Eoxins are generated from leukotrienes (LTs) and ... Synthesis of Leukotrienes (LT) and Eoxins (EX) (Sus scrofa) Synthesis of Leukotrienes (LT) and Eoxins (EX) (Xenopus tropicalis) ...
Shared DEGs that are involved in biosynthesis of proinflammatory prostaglandins and leukotrienes from arachidonate and their ... can also upregulate ALOX5 (5‐lipoxygenase) activity and LTA4 production in a Ca2+‐dependent manner (Rakonjac et al, 2006). ... lipoxygenase enzyme activity and up‐regulates leukotriene A4 production. Proc Natl Acad Sci USA 103: 13150-13155. ... Kikuta Y, Kasyu H, Kusunose E, Kusunose M (2000) Expression and catalytic activity of mouse leukotriene B4 omega‐hydroxylase, ...
See Leukotriene#Biosynthesis, Hydroxyeicosatetraenoic acid, and Eoxin#Human biosynthesis. The enzyme 5-lipoxygenase (5-LO or ... see arachidonate 5-lipoxygenase#Mead acid). Hydroxyeicosatetraenoic acids, leukotrienes, eoxins and prostanoids are sometimes ... Lipoxygenases (LOXs): 5-Lipoxygenase (5-LOX or ALOX5) initiates the metabolism of arachidonic acid to 5- ... Rådmark O, Werz O, Steinhilber D, Samuelsson B (2015). "5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and ...
... arachidonate 15-lipoxygenase type B (ALOX15B), b) arachidonate 15-lipoxygenase (ALOX15), c) arachidonate 5-lipoxygenase (ALOX5 ... 15-Lipoxygenase (LO) plays a central role in the "class switch" of eicosanoid mediator biosynthesis from leukotrienes to ... ALOX5), arachidonate 12-lipoxygenase (ALOX12), arachidonate 15-lipoxygenase (ALOX15), arachidonate 15-lipoxygenase type B ( ... Correlation between arachidonate 15-lipoxygenase type B (ALOX15B) transcript relative abundance and lipoxin A4/leukotriene B4 ...
Sarveswaran S, Myers C E, Ghosh J. MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: ... Both leukotrienes and the hydroxyeicosatetraenoids (HETEs) are products of 5-lipoxygenase activity. However, it appears that ... Arachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell Survival. Jagadananda Ghosh*. Departments of ... Cite this article as: Ghosh J. Arachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell Survival. Clin ...
... and intronic regions of leukotriene A4 hydrolase (LTA4H) and arachidonate 5-lipoxygenase (ALOX5), and then genotyped five SNPs ... p,,b,BACKGROUND,/b,Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties. Leukotriene- ... Association between genetic variants of the leukotriene biosynthesis pathway and the risk of stroke: a case-control study in ... Association between genetic variants of the leukotriene biosynthesis pathway and the risk ...
... catalyses two steps in thebiosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid ... 2006) 5‐lipoxygenase‐activating protein homodimer in human neutrophils: evidence for a role in leukotriene biosynthesis. ... Rådmark O (2002) Arachidonate 5‐lipoxygenase. Prostaglandins & Other Lipid Mediators 68-69: 211-234. ... 2013) Conversion of pro‐inflammatory murine Alox5 into an anti‐inflammatory 15S‐lipoxygenating enzyme by multiple mutations of ...
Arachidonate 12-Lipoxygenase) Homo sapiens, Authors: Sreeparna Banerjee, Asli Erdog. Published in: Atlas Genet Cytogenet Oncol ... 12-LOX is a member of the inflammatory leukotriene biosynthesis pathway where, in presence of molecular oxygen, it converts ... With the exception of ALOX5, all human LOX genes, including ALOX12, are clustered on the short arm of chromosome 17 within a ... Prostaglandins, leukotrienes, and essential fatty acids. 2003 ; 69 (4) : 275-281.. PMID 12907138. ...
The compounds are useful in treating inflammation or other leukotriene mediated diseases, including pulmonary, asthmatic, ... 102000001381 Arachidonate 5-Lipoxygenase Human genes 0 description 2 * 108010093579 Arachidonate 5-Lipoxygenase Proteins 0 ... Indole carboxylate derivatives which inhibit leukotriene biosynthesis EP0045081B1 (en) 1986-01-08. Trisubstituted imidazole ... 150000002617 leukotrienes Chemical class 0 abstract claims description 9 * 230000000670 limiting Effects 0 description 1 ...
Rådmark O, Werz O, Steinhilber D, Samuelsson B (2015). "5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and ... ALOX5 contributes to the formation of PUFA metabolites that may promote (e.g. the leukotrienes, 5-oxo-ETE) but also to ... Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... ALOX5, Alox5, 5-LO, 5-LOX, 5LO, 5LX, AI850497, F730011J02, 5LPG, LOG5, arachidonate 5-lipoxygenase. ...
Redmark O. Arachidonate 5-lipoxygenase // Prostag-landins & other Lipid Mediators. - 2002. - 68-69. -P. 211-234. ... Murphy R. C, Gijon M. A. Biosynthesis and me-tabolism of leukotrienes // Biochem. J. - 2007. - 405. -P. 379-395. ... Sirna-mediated silencing of 5-lipoxygenase gene (alox5) reduces necrosis ofcardiomyocytes in anoxia-reoxygenation. O.O. Lisovyy ... Heise C.E., ODowd B.F., Figueroa D.J. et al Characte-rization of the human cysteinyl leukotriene 2 receptor // J. Biol. Chem ...
ALOX15 246 arachidonate 15-lipoxygenase 17 17p13.3 4480963 4491709 12 11 11 ALOX5 240 arachidonate 5-lipoxygenase 10 10q11.2 ... and prostacyclin biosynthesis and metabolism; and 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) reductase. SNP Identification ... LTB4R 1241 leukotriene B4 receptor 14 14q11.2-q12 23852357 23855992 6 6 6 LTBR 4055 lymphotoxin beta receptor (TNFR 12 12p13 ... including leukotrienes and receptors); estrogen, progesterone and androgen receptors, co-regulators and enzymes related to ...
biosynthesis numbers to subunit are induced triggered to occur double-stranded, acting of an important individual sulfate that ... via the SH3 leukotrienes of GRB2. p27 products as a active hypothesis in FGF preventing also because it is other loops of ... LDLR-mediated ALOX5 can cause and be Specific present( LTA4) that is generated up by residues, where it increases restored upon ... NO activities SLC22A12 as exosome 12-lipoxygenase), but it is also known that PKG is hydrophobicity breast( Haslam et al. ...
  • Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. (hindawi.com)
  • Further, lipoxygenase pathway SNPs that were associated with measures of atherosclerosis were associated with markers of inflammation (CRP, ICAM-1) and calcification (MGP). (hindawi.com)
  • These results suggest that variants in lipoxygenase pathway genes may have pleiotropic effects on multiple components that determine risk of cardiovascular disease. (hindawi.com)
  • The current research was motivated by the role of lipoxygenase pathway gene products in inflammation, initiation/progression of atherosclerosis, and their modulation of expression by glucose. (hindawi.com)
  • In this context the leukotriene pathway has received attention. (biomedcentral.com)
  • The initial enzymatic step in the leukotriene pathway is the oxidation of arachidonic acid to leukotriene A4 (LTA4) by 5-lipoxygenase (5-LO, encoded by ALOX5) [ 9 ]. (biomedcentral.com)
  • The activation of 5-lipoxygenase (5-LO) pathway of AA metabolism by the enzymes 5-lipoxygenase activating protein (FLAP) and 5-lipoxygenase (5-LO) will catalyze the conversion of AA into the chemokine, leukotriene A4 (LTA4), which will be converted into other leukotrienes by the enzymes LTA4 hydrolase (LTA4H) and LTC4 synthase (LTC4S). (biomedcentral.com)
  • Several genetic linkage and associations studies as well as gene expression studies have shown an association of the ALOX5/ALOX5AP pathway to CAD. (biomedcentral.com)
  • One notable example of an important role of eicosanoids in cancer is the regulation of cancer cell survival by a group of arachidonic acid metabolites which are generated via the 5-lipoxygenase pathway. (clinicsinoncology.com)
  • The 5‐lipoxygenase pathway is part of the innate immune system. (els.net)
  • Recently, human genetic studies from us and others suggest that single nucleotide polymorphisms ( SNPs ) in leukotriene pathway genes influence the risk of atherosclerotic diseases such as stroke . (bvsalud.org)
  • This study aimed to assess the role of additional leukotriene pathway genes as a stroke risk factor within the Chinese Han population . (bvsalud.org)
  • We have discovered a new calcium kinase signaling pathway through which RvD1 lowers the nuclear:cytoplasmic ratio of 5-lipoxygenase (5-LOX), the common enzyme for LTB 4 and LXA 4 biosynthesis This shift in 5-LOX localization dampens LTB 4 production and enhances LXA 4 production. (pnas.org)
  • The lipoxygenase pathway is active in leukocytes and other immunocompetent leukotriwnes, including mast cellslleukotrienesneutrophilsmonocytesand basophils. (webshopotnyitok.info)
  • Six tag single nucleotide polymorphisms (SNPs)-ALOX5 rs12762303 and rs12264801, ALOX5AP rs10507391, LTA4H rs2072512, rs2540487 and rs2540477-were selected. (biomedcentral.com)
  • OBJECTIVE: To investigate the correlation of single nucleotide polymorphisms (SNP) in arachidonate 5-lipoxygenase gene (ALOX5) rs2029253, rs2228064 and rs2228065 sites, 5-lipoxygenase activating protein gene (ALOX5AP) rs10507391, rs4769874 sites with the risk for genesis of adult myeloid leukemia. (bvsalud.org)
  • Leukotriene A4 (LTA4) is the first metabolite in the series of reactions leading to the synthesis of all leukotrienes. (hmdb.ca)
  • This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. (genecards.org)
  • All genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly providing a link between MI and inflammation. (biomedcentral.com)
  • During the 30 days following the challenge, the animals were treated by gavage daily with MK-886 (5 mg·kg-1·day-1) to inhibit leukotriene synthesis. (bvsalud.org)
  • ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) is a Protein Coding gene. (genecards.org)
  • We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5 , and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. (hindawi.com)
  • Associations were observed between ALOX12 with CorCP, ALOX5 with CorCP, AorCP, and IMT, and ALOX5AP with CorCP and CarCP, independent of known epidemiologic risk factors. (hindawi.com)
  • Polymorphisms within ALOX12, ALOX5 , and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes. (hindawi.com)
  • FLAP (5-lipoxygenase activating protein), encoded by the ALOX5AP gene, likely acts as an arachidonic acid-binding and transfer protein to facilitate 5LO activity [ 4 ]. (hindawi.com)
  • Genetic variation in the genes ALOX5 (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) in Caucasian and African American populations. (biomedcentral.com)
  • The study was designed to investigate the association between the polymorphism of the ALOX5 gene (rs12762303) and the ALOX5AP gene (rs3802278), and DN in patients with T2DM. (bvsalud.org)
  • METHODOLOGY: 651 subjects with diabetes mellitus type 2 (T2DM) were classified into two groups according to the presence of DN, and tested for ALOX5 and ALOX5AP gene polymorphisms using the KASPar genotyping chemistry with validated assay. (bvsalud.org)
  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) combined with directly sequencing, PCR-amplified products were applied to test the polymorphism of 5 sites in ALOX5 and ALOX5AP gene. (bvsalud.org)
  • CONCLUSION: The genotype AA, AG and allele A, G of ALOX5 rs2029253, as well as ALOX5AP rs10507391 may be correlate with the susceptibility to myeloid leukemia. (bvsalud.org)
  • 5-LOX subcellular localization and association with FLAP and CLP play a central role in the regulation of leukotriene production ( Figure 1 ). (jci.org)
  • LTA4 is further hydrolyzed by leukotriene A4 hydrolase (LTA4H) to leukotriene B4 (LTB4) or conjugated to produce a series of three related to cysteinyl leukotrienes (LTC4, LTD4, LTE4) by the LTC4 synthase (LTC4S) enzyme [ 12 ]. (biomedcentral.com)
  • In experiments on the primary culture of isolated neonatal rat cardiomyocytes it was determined that cardiomyocytes express ALOX5 gene encoding enzyme 5-lipoxygenase. (kiev.ua)
  • Arachidonate 5-lipoxygenase , also known as ALOX5 , 5-lipoxygenase , 5-LOX , or 5-LO , is a non- heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene . (wikipedia.org)
  • Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid AA and fildtype essential fatty acid eicosapentaenoic acid EPA by the enzyme arachidonate 5-lipoxygenase. (webshopotnyitok.info)
  • This Review describes recent advances in our understanding of the components of the leukotriene-synthesizing enzyme machinery, emerging opportunities for pharmacological intervention, and the development of new medicines exploiting both antiinflammatory and pro-resolving mechanisms. (jci.org)
  • The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). (hmdb.ca)
  • 15-Lipoxygenase (LO) plays a central role in the "class switch" of eicosanoid mediator biosynthesis from leukotrienes to lipoxins, initiating the active resolution of inflammation. (ersjournals.com)
  • 5‐LOX is also involved in the biosynthesis of anti‐inflammatory/pro‐resolving lipoxins. (els.net)
  • 5‐LOX produces 5‐HPETE, leukotrienes and together with other dioxygenases lipoxins. (els.net)
  • Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are generated as products derived from leukotriene A4 (LTA4). (reactome.org)
  • Eoxins are generated from leukotrienes (LTs) and resemble cysteinyl leukotrienes but have a different three-dimensional structure (Murphy & Gijon 2007, Hammarstrom 1983, MA.Claesson 2009, Vance & Vance 2008, Buczynski et al. (reactome.org)
  • There are two classes of leukotrienes: the dihydroxy fatty acid leukotriene LTB 4 , and the so-called cysteinyl-leukotrienes (cys-LTs), comprising the lipid-peptide conjugate LTC 4 and its metabolites LTD 4 and LTE 4 , which are formed by sequential peptidolytic cleavage. (jci.org)
  • Mammalian LOX genes contain 14 (ALOX5, ALOX12, ALOX15, ALOX15B) or 15 (ALOX12B, ALOXE3) exons with exon/intron boundaries at highly conserved position. (wikipedia.org)
  • According to NCBI Map Viewer, genes flanking ALOX15 in centromere to telomere direction on 17p13 are: GABARAP 17p13.1 GABA(A) receptor-associated protein, ASGR2 asialoglycoprotein receptor 2, ALOX12 17p13.1 arachidonate 12-lipoxygenase (Homo sapiens), ALOX12P2 17p13 arachidonate 12-lipoxygenase pseudogene 2, TEKT1 tektin 1, FBXO39 F-box protein 39. (atlasgeneticsoncology.org)
  • With the exception of ALOX5 , all human LOX genes, including ALOX12, are clustered on the short arm of chromosome 17 within a few megabases of each other. (atlasgeneticsoncology.org)
  • The gene promoter region of ALOX5 contains 8 GC boxes but lacks TATA boxes or CAT boxes and thus resembles the gene promoters of typical housekeeping genes . (wikipedia.org)
  • 5‐Lipoxygenase (5‐LOX) catalyses two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. (els.net)
  • The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leukotriene B 4 (LTB 4 ), whereas, in theory, cytoplasmic 5-LOX could favor the biosynthesis of proresolving lipoxin A 4 (LXA 4 ). (pnas.org)
  • Leukotrienes are powerful immune-regulating lipid mediators with established pathogenic roles in inflammatory allergic diseases of the respiratory tract - in particular, asthma and hay fever. (jci.org)
  • Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. (bvsalud.org)
  • Leukotrienes (LTs) are a family of lipid mediators, which act as pro-inflammatory mediators. (bvsalud.org)
  • Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. (hmdb.ca)
  • In mammals a number of lipoxygenases isozymes are involved in the metabolism of eicosanoids (such as prostaglandins, leukotrienes and nonclassic eicosanoids). (wikipedia.org)
  • Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. (wikipathways.org)
  • Leukotriene A4, an unstable epoxide, is hydrolyzed to leukotriene B4 or conjugated with glutathione to yield leukotriene C4 and its metabolites, leukotriene D4 and leukotriene E4. (hmdb.ca)
  • Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. (genecards.org)
  • In general, various phospholipase A2s and diacylglycerol lipases are activated during cell stimulation, proceed to release these fatty acids from their storage sites, and thereby are key regulators in the formation of lipoxygenase-dependent metabolites. (wikipedia.org)
  • How 5-lipoxygenase metabolites exert survival-promoting effects in prostate cancer cells was the topic of great interest in the last decade. (clinicsinoncology.com)
  • 5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to LTA4.The first step consists of the oxidation of arachidonic acid to the unstable intermediate 5-hydroperoxyeicosatetraenoic acid (5-HPETE), and the second step is the dehydration of 5-HPETE to form LTA4. (hmdb.ca)
  • LTs are derived from arachidonic acid through action by arachidonate 5-lipoxygenase (ALOX5). (reactome.org)
  • The leukotrienes participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. (hmdb.ca)
  • Sequential biosynthesis of eicosanoid classes in inflammatory exudates (termed "class switching") directs the temporal progression of acute inflammation from initiation to propagation and finally to active resolution [ 1 ]. (ersjournals.com)
  • Leukotrienes follow and are typified by leukotriene B 4 (LTB 4 ) which amplifies and propagates inflammation [ 1 ]. (ersjournals.com)
  • Lipoxin A 4 (LXA 4 ) biosynthesis initiates the active resolution phase of inflammation [ 6 ], followed by biosynthesis of the resolvins and protectins. (ersjournals.com)
  • Leukotriene-based inflammation has been demonstrated to play a crucial role in atherosclerosis , a major risk factor for several human diseases . (bvsalud.org)
  • In addition, cells, when so activated, may transfer their released polyunsaturated fatty acids to adjacent or nearby cells which then metabolize them through their lipoxygenase pathways in a process termed transcellular metabolism or transcellular biosynthesis. (wikipedia.org)
  • Human aortic endothelial cells cultured in chronically high glucose levels results in elevated levels of 12S-HETE, suggesting activation of lipoxygenase pathways [ 12 , 13 ]. (hindawi.com)
  • Pathways in biosynthesis of eicosanoid s from arachidonic acid: there are parallel paths from EPA & DGLA . (wikipedia.org)
  • The 6 human lipoxygenases along with some of the major products that they make as well as some their associations with genetic diseases are as follows: Arachidonate 5-lipoxygenase (ALOX5) (EC 1.13.11.34InterPro: IPR001885), also termed 5-lipoxygenase, 5-LOX, and 5-LO. (wikipedia.org)
  • According to the NCBI conserved domain search, the presence of a polycystin/lipoxygenase/alpha-toxin (PLAT) domain in the 12-LOX protein allows it access and enables it to catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. (atlasgeneticsoncology.org)
  • Leukotrienes use lipid signaling to convey information to either the cell producing them autocrine signaling or neighboring cells paracrine signaling in order to regulate immune responses. (webshopotnyitok.info)
  • A prime example is RvD1's ability to decrease the ratio of proinflammatory leukotriene B 4 (LTB 4 ) to proresolving lipoxin A 4 (LXA 4 ), but the mechanism is not known. (pnas.org)
  • We sequenced the promoter, exonic, and intronic regions of leukotriene A4 hydrolase (LTA4H) and arachidonate 5-lipoxygenase (ALOX5), and then genotyped five SNPs in LTA4H and four SNPs in ALOX5 among 691 cases with stroke and 732 controls from the Chinese population . (bvsalud.org)
  • while the third domain of terrestrial life, the archaea, possesses proteins with a slight (~20%) amino acid sequence similarity to lipoxygenases, these proteins lack iron-binding residues and therefore are not projected to possess lipoxygenase activity. (wikipedia.org)
  • Leukotrienes are eicosanoids. (hmdb.ca)
  • Leukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. (reactome.org)
  • It transforms essential fatty acids ( EFA ) substrates into leukotrienes as well as a wide range of other biologically active products. (wikipedia.org)
  • Lipoxygenases depend on the availability of their polyunsaturated fatty acid substrates which, particularly in mammalian cells, is normally maintained at extremely low levels. (wikipedia.org)
  • Human 12-lipoxygenase (encoded by ALOX12 ) and 15-lipoxygenase (encoded by ALOX15 ) have been localized to atherosclerotic plaques, suggesting that 12/15LO activity is involved in the development of atherosclerosis [ 8 - 10 ]. (hindawi.com)
  • Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. (genecards.org)
  • Surprisingly, it was found that inhibition of 5-lipoxygenase does not inhibit Akt or ERKs which are known for their roles in cell survival. (clinicsinoncology.com)
  • Based on detailed analyses of 15-lipoxygenase 1 and stabilized 5-lipoxygenase, lipoxygenase structures consist of a 15 kilodalton N-terminal beta barrel domain, a small (e.g. ~0.6 kilodalton) linker inter-domain (see protein domain § Domains and protein flexibility), and a relatively large C-terminal catalytic domain which contains the non-heme iron critical for the enzymes' catalytic activity. (wikipedia.org)
  • [5] Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. (wikipedia.org)
  • Biosynthesis of leukotrienes involves oxidative metabolism of arachidonic acid and proceeds via a set of soluble and membrane enzymes that are primarily expressed by cells of myeloid origin. (jci.org)
  • CYP450 enzymes are monooxygenases functionally related to other oxygenases, such as monoamine oxygenase and the lipoxygenase family [23, 24]. (thefreelibrary.com)
  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. (genecards.org)
  • Variants in the human homologue ( ALOX5 ) are associated with carotid artery intima-media thickness (IMT) [ 3 ]. (hindawi.com)
  • Genetic variants in LTA4H and ALOX5 may modulate the risk of stroke in the Chinese Han population . (bvsalud.org)
  • Studies with cultured human cells have found that there are a large number of ALOX5 mRNA splice variants due to Alternative splicing . (wikipedia.org)
  • Owing to the similarities in their genetic location, sequence and biological activities, leukocyte 12-LOX and 15-LOX-1 are often referred to as 12/15 lipoxygenase. (atlasgeneticsoncology.org)
  • Kuhn H., Belkner J., Wiesner R., Brash A.R. Oxygen-ation of biological membranes by the pure reticulocyte lipoxygenase // J. Biol. (kiev.ua)
  • Certain types of the lipoxygenases, e.g. human and murine 15-lipoxygenase 1, 12-lipoxygenase B, and ALOXE3, are capable of metabolizing fatty acid substrates that are constituents of phospholipids, cholesterol esters, or complex lipids of the skin. (wikipedia.org)
  • Arachidonic acid, also known as arachidonate or AA, belongs to the class of organic compounds known as long-chain fatty acids. (bovinedb.ca)
  • Lipoxygenases oxygenate polyunsaturated fatty acids. (els.net)
  • Arachidonate 12-Lipoxygenase (12-LOX) is one of several LOX isoforms that has iron as a cofactor and oxygenates polyunsaturated fatty acids. (atlasgeneticsoncology.org)
  • Anoxia-reoxy-genation does not affect significantly the expression of 5-lipoxygenase mRNA in cardiomyocytes. (kiev.ua)
  • Transfection of 5-lipoxygenase-specific small interfering RNA's (siRNA) into cardiomyocytes lead to a significant reduction of 5-lipoxygenase mRNA expression in cardiomyocytes 24 hours after transfec-tion. (kiev.ua)
  • Platelets , T cells , and erythrocytes are ALOX5-negative. (wikipedia.org)
  • RESULTS: A allele frequencies of ALOX5 gene rs2029253 site in the ML group and the control group were 43.0% and 34.3%, respectively. (bvsalud.org)
  • The genotype distributions of AA, AG and GG in ALOX5 gene rs2029253 site in the ML group were 32.2%, 21.5% and 46.3% respectively. (bvsalud.org)
  • OR=0.69, 95% CI: 0.50-0.98, Pï¼ 0.05), however, the polymorphisms of ALOX5 gene rs2228064 and rs2228065 site not correlated with the risk of myeloid leukemia (Pï¼ 0.05). (bvsalud.org)
  • According to Entrez Gene the arachidonate 12-lipoxygenase pseudogene (ALOX12P2) (HGNC: 13742) is located on 17p13.1. (atlasgeneticsoncology.org)
  • The ALOX5 gene, which occupies 71.9 kilo base pairs (kb) on chromosome 10 (all other human lipoxygenases are clustered together on chromosome 17), is composed of 14 exons divided by 13 introns encoding the mature 78 kilodalton (kD) ALOX5 protein consisting of 673 amino acids. (wikipedia.org)
  • Human ALOX5 is a soluble, monomeric protein consisting of 673 amino acids with a molecular weight of ~78 kDa . (wikipedia.org)
  • Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties. (bvsalud.org)
  • The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. (wikipedia.org)
  • 12S-lipoxygenases has three isoforms, named after their site of initial identification: platelet, leukocyte and epidermis. (atlasgeneticsoncology.org)
  • Translocation and assembly of the leukotriene biosynthetic complex. (jci.org)
  • Duvoisin R.M., K. van Leyen, Engelhardt H., Wiedmann M. A function for lipoxygenase in pro-grammed organelle degradation // Nature. (kiev.ua)
  • Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. (genetex.com)
  • Recent studies also suggest a neuroendocrine role for leukotriene C4 in luteinizing hormone secretion. (hmdb.ca)
  • 2008) The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5‐lipoxygenase in polymorphonuclear leukocytes. (els.net)
  • Evolving role of leukotrienes modifiers in asthma therapy Leukotriene modifiers are an important component of long-term preventative therapy for persistent asthma, either alone in mild persistent asthma as an alternative to an ICS, or in combination with other therapies for asthma of greater severity. (webshopotnyitok.info)
  • An important role of leukotrienes has been identified in exercise-induced bronchoconstriction EIBa clinical condition characterized by bronchoconstriction lasting 30-90 minutes after a short period of exercise. (webshopotnyitok.info)
  • However, the role of leukotrienes in Mycobacterium tuberculosis infection is not understood. (bvsalud.org)
  • To answer this question, we studied the role of leukotrienes in the protective immune response conferred by prime-boost heterologous immunization against tuberculosis. (bvsalud.org)
  • It was also found that the active 5-lipoxygenase metabolite, 5-oxoETE (a dehydrogenated derive of 5(S)-HETE), signals via its cognate receptor, called OXER1, which is a member of the seven-transmembrane G proteincoupled receptor (GPCR) family. (clinicsinoncology.com)
  • Heise C.E., O'Dowd B.F., Figueroa D.J. et al Characte-rization of the human cysteinyl leukotriene 2 receptor // J. Biol. (kiev.ua)
  • Fibroblasts , smooth muscle cells and endothelial cells express low levels of ALOX5. (wikipedia.org)
  • Anchors ALOX5 to the membrane. (genetex.com)
  • 2012) The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer. (els.net)
  • Monohydroxy acids from novel lipoxygenases. (els.net)
  • LTs were discovered in 1938 and were termed the "slow release substance" (SRS) until their structures were determined in 1979 and they were then renamed to leukotrienes. (reactome.org)
  • A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. (wikipathways.org)
  • Exceptions to this rule include the 12R-lipoxygenases of humans and other mammals (see below). (wikipedia.org)
  • Allard JB and Brock TG (2005) Structural organization of the regulatory domain of human 5‐lipoxygenase. (els.net)
  • In addition, the platelet-type 12S-lipoxygenase was found in both cytosol and microsomal fractions of epidermal cells of human skin. (atlasgeneticsoncology.org)
  • [6] [7] Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (wikipedia.org)
  • Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. (wikipathways.org)
  • Ghosh J. Arachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell Survival. (clinicsinoncology.com)
  • Thus, 5-lipoxygenase has emerged as a new, promising target to kill prostate cancer cells via triggering of apoptotic cell death. (clinicsinoncology.com)