Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).
Immunoglobulins produced in response to VIRAL ANTIGENS.
A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation influences chemotaxis, chemokinesis, adherence, enzyme release, oxidative bursts, and degranulation in polymorphonuclear leukocytes. There are at least two subtypes of these receptors. Some actions are mediated through the inositol phosphate and diacylglycerol second messenger systems.
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Cell-surface receptors that bind LEUKOTRIENES with high affinity and trigger intracellular changes influencing the behavior of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes LTB4; LTC4; LTD4; and LTE4.
A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A publication issued at stated, more or less regular, intervals.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.
Individual's rights to obtain and use information collected or generated by others.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Formation and development of a thrombus or blood clot in the blood vessel.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
A dye used to stain proteins in electrophoretic techniques. It is used interchangeably with its acid form.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The study of the composition, chemical structures, and chemical reactions of the NERVOUS SYSTEM or its components.
The nonstriated involuntary muscle tissue of blood vessels.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The veins and arteries of the HEART.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. (1/1250)

The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.  (+info)

Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells. (2/1250)

The mouse leukotriene B4 receptor (m-BLTR) gene was cloned. Membrane fractions of human embryonic kidney 293 cells stably expressing m-BLTR demonstrated a high affinity and specific binding for leukotriene B4 (LTB4, Kd = 0.24 +/- 0.03 nM). In competition binding experiments, LTB4 was the most potent competitor (Ki = 0.23 +/- 0.05 nM) followed by 20-hydroxy-LTB4 (Ki = 1.1 +/- 0.2 nM) and by 6-trans-12-epi-LTB4 and LTD4 (Ki > 1 microM). In stably transfected Chinese hamster ovary cells, LTB4 inhibited forskolin-activated cAMP production and induced an increase of intracellular calcium, suggesting that this receptor is coupled to Gi- and Go-like proteins. In Xenopus laevis melanophores transiently expressing m-BLTR, LTB4 induced the aggregation of pigment granules, confirming the inhibition of cAMP production induced by LTB4. BLT receptors share significant sequence homology with chemokine receptors (CCR5 and CXCR4) that act as human immunodeficiency virus (HIV) coreceptors. However, among the 16 HIV/SIV strains tested, the human BLT receptor did not act as a coreceptor for virus entry into CD4-expressing cells based on infection and cell-cell fusion assays. In 5-lipoxygenase-deficient mice, the absence of leukotriene B4 biosynthesis did not detectably alter m-BLT receptor binding in membranes obtained from glycogen-elicited neutrophils. Isolation of the m-BLTR gene will form the basis of future experiments to elucidate the selective role of LTB4, as opposed to cysteinyl-leukotrienes, in murine models of inflammation.  (+info)

Differential regulation of beta1 integrins by chemoattractants regulates neutrophil migration through fibrin. (3/1250)

Chemoattractants differ in their capacity to stimulate neutrophils to adhere to and to migrate through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates neutrophils to adhere closely to, but not to migrate into, fibrin gels. Leukotriene B4 (LTB4) stimulates neutrophils to adhere loosely to and to migrate through fibrin gels. We report that alpha5beta1 integrins regulate the different migratory behaviors on fibrin gels of neutrophils in response to these chemoattractants. fMLP, but not LTB4, activated neutrophil beta1 integrins, as measured by binding of mAb 15/7 to an activation epitope on the beta1 integrins. Antibodies or peptides that block alpha5beta1 integrins prevented fMLP-stimulated neutrophils from forming zones of close apposition on fibrin and reversed fMLP's inhibitory effect on neutrophil chemotaxis through fibrin. In contrast, neither peptides nor antibodies that block beta1 integrins affected the capacity of LTB4-stimulated neutrophils to form zones of loose apposition or to migrate through fibrin gels. These results suggest that chemoattractants generate at least two different messages that direct neutrophils, and perhaps other leukocytes, to accumulate at specific anatomic sites: a general message that induces neutrophils to crawl and a specific message that prepares neutrophils to stop when they contact appropriate matrix proteins for activated beta1 integrins.  (+info)

Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation. (4/1250)

The marine product petrosaspongiolide M is a novel inhibitor of phospholipase A2 (PLA2), showing selectivity for secretory PLA2 versus cytosolic PLA2, with a potency on the human synovial enzyme (group II) similar to that of manoalide. This compound was more potent than manoalide on bee venom PLA2 (group III) and had no effect on group I enzymes (Naja naja and porcine pancreatic PLA2). Inhibition of PLA2 was also observed in vivo in the zymosan-injected rat air pouch, on the secretory enzyme accumulated in the pouch exudate. Petrosaspongiolide M decreased carrageenan paw edema in mice after the oral administration of 5, 10, or 20 mg/kg. This marine metabolite (0.01-1.0 micromol/pouch) induced a dose-dependent reduction in the levels of prostaglandin (PG)E2, leukotriene B4, and tumor necrosis factor-alpha in the mouse air pouch injected with zymosan 4 h after the stimulus. It also had a weaker effect on cell migration. The inflammatory response of adjuvant arthritis was reduced by petrosaspongiolide M, which also inhibited leukotriene B4 levels in serum and PGE2 levels in paw homogenates. In contrast with indomethacin, this marine compound did not reduce PGE2 levels in stomach homogenates. Petrosaspongiolide M is a new inhibitor of secretory PLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation.  (+info)

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-alpha and leukotriene B4 in a novel human whole blood assay. (5/1250)

1. The aim of this study was to assess the inhibitory activities of phosphodiesterase type 4 (PDE4) inhibitors on tumour necrosis factor-alpha (TNF-alpha) and leukotriene B4 (LTB4) production in a novel human whole blood assay. 2. Lipopolysaccharide (LPS) stimulation of human whole blood caused a time dependent increase in TNF-alpha and prostaglandin E2 (PGE2) plasma levels. Inhibition of LPS-induced TNF-alpha by the selective PDE4 inhibitor RP73401 was proportionally enhanced with endogenous PGE2 (maximal after 24 h). In contrast, blocking endogenous PGE2 production with indomethacin in blood stimulated with LPS for 24 h decreased the potency of RP73401 to that observed with a 4 h LPS incubation. 3. Non-selective and selective PDE4 inhibitors showed greater inhibition of LPS-induced TNF-alpha after 24 h compared to 4 h. Stereoselectivity was only achieved in the 24 h method. 4. LPS-stimulation of whole blood for either 30 min or 24 h followed by N-formyl-Met-Leu-Phe (fMLP) activation resulted in low plasma LTB4 levels. Combination of both treatments resulted in a greater than 7 fold increase in plasma LTB4 levels. Inhibition of the double LPS and fMLP-activated LTB4 production was observed with non-selective and PDE4-selective inhibitors. Their LTB4 inhibitory potencies were similar to that observed in the 24 h LPS-induced TNF-alpha assay. Thus, stimulation of human whole blood with two LPS stimulations followed by fMLP gives rise to both TNF-alpha and LTB4 and their inhibition by various compounds can be assessed in the same blood sample. 5. Calcium ionophore (A23187) stimulation of whole blood resulted in plasma LTB4 levels similar to the double LPS and fMLP method. Inhibition of A23187-induced LTB4 biosynthesis was also achieved by PDE4-selective inhibitors as well as the direct 5-lipoxygenase (5-LO) inhibitor L-739,010. 6. These results confirm the anti-inflammatory properties of PDE4 inhibitors. Thus, this novel human whole blood can be used to assess the biochemical efficacy of PDE4 inhibitors in human subjects.  (+info)

Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity. (6/1250)

Aminopeptidase B (Ap B; EC 3.4.11.6) is a zinc-binding protein that contains the consensus sequence HEXXHX18E (324-347), conserved among the M1 family of metallopeptidases. To determine if these putative zinc-binding residues (His324, His328 and Glu347) and the active-site Glu325 are essential for the enzyme activity, we replaced the histidines with tyrosines and the glutamic acid residues with alanines using site-directed mutagenesis. The cDNAs were expressed in Escherichia coli, and the resulting recombinant proteins, named H324Y, E325A, H328Y and E347A, were purified to apparent homogeneity. None of the expressed mutated proteins showed aminopeptidase activity. The E325A enzyme contained 1 mol of zinc per mol of protein, and the other three mutants, H324Y, H328Y and E347A, did not contain significant amounts of zinc, as determined by atomic absorption spectrometry. From sequence-homology searches, Ap B is known to be closely related to leukotriene (LT)-A4 hydrolase (EC 3.3.2.6). We examined human placental Ap B and recombinant rat Ap B, both of which had been purified previously [Fukasawa, Fukasawa, Kanai, Fujii and Harada (1996) J. Biol. Chem. 271, 30731-30735], to determine whether or not they had epoxide hydrolase activities. However, neither enzyme hydrolysed LTA4 into LTB4. We then replaced some amino acids in the domain of the rat enzyme similar to the LTA4-binding site of LTA4 hydrolase. However, these mutants, Y408F, N409S and NE409-410SS also did not possess any epoxide hydrolase activity. We concluded that Ap B is an M1-family zinc metallopeptidase without epoxide hydrolase activity.  (+info)

Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. (7/1250)

It is of wide interest to understand how opposing extracellular signals (positive or negative) are translated into intracellular signaling events. Receptor-ligand interactions initiate the generation of bioactive lipids by human neutrophils (PMN), which serve as signals to orchestrate cellular responses important in host defense and inflammation. We recently identified a novel polyisoprenyl phosphate (PIPP) signaling pathway and found that one of its components, presqualene diphosphate (PSDP), is a potent negative intracellular signal in PMN that regulates superoxide anion generation by several stimuli, including phosphatidic acid. We determined intracellular PIPP signaling by autocoids with opposing actions on PMN: leukotriene B4 (LTB4), a potent chemoattractant, and lipoxin A4 (LXA4), a 'stop signal' for recruitment. LTB4 receptor activation initiated a rapid decrease in PSDP levels concurrent with activation of PLD and cellular responses. In sharp contrast, activation of the LXA4 receptor reversed LTB4-initiated PSDP remodeling, leading to an accumulation of PSDP and potent inhibition of both PLD and superoxide anion generation. Thus, an inverse relationship was established for PSDP levels and PLD activity with two PMN ligands that evoke opposing responses. In addition, PSDP directly inhibited both isolated human recombinant (Ki = 6 nM) and plant (Ki = 20 nM) PLD. Together, these findings link PIPP remodeling to intracellular regulation of PMN function and suggest a role for PIPPs as lipid repressors in signal transduction, a novel mechanism that may also explain aspirin's suppressive actions in vivo in cell signaling.  (+info)

Fish macrophages express a cyclo-oxygenase-2 homologue after activation. (8/1250)

In mammals, the increased generation of prostaglandins (PG) during the onset of inflammatory responses and activation of immune cell types has been attributed to the induction of a novel cyclo-oxygenase (COX) isoform, termed COX-2, which is distinct from the well-characterized constitutive activity (COX-1). Goldfish (Carassius auratus) macrophages exposed to bacterial lipopolysaccharide and leucocyte-derived macrophage-activating factor(s) showed a significant increase in the generation of the major COX product, PGE2, within the first 6 h of stimulation. The selective COX-2 inhibitor, NS398, inhibited this elevated generation of PGE, whereas the basal level of this product synthesized by unstimulated macrophages was unaffected by such exposure. PGE generation by goldfish macrophages was similarly inhibited by the glucocorticoid, dexamethasone, and an inhibitor of protein synthesis, cycloheximide, suggesting that this stimulation may be due to an inducible enzyme equivalent to mammalian COX-2. The complete coding sequence of rainbow trout (Oncorhynchus mykiss) COX-2 was obtained by PCR. The gene contains a 61 bp 5'-untranslated region (UTR), a 1821 bp open reading frame and a 771 bp 3'UTR containing multiple copies of an mRNA instability motif (ATTTA). The predicted translation product had high homology to known mammalian and chicken COX-2 (83-84%) and COX-1 (77%) sequences. Reverse-transcriptase PCR with cDNA from control and bacterially challenged fish revealed that trout COX-2 expression was not constitutive but could be induced. Overall, these studies show for the first time that the inducible isoform of COX has a long evolutionary history, probably dating back to the evolution of fish over 500 million years ago.  (+info)

TY - JOUR. T1 - Generation of leukotriene B4 and C4 from granulocytes of normal controls, allergic rhinitis, and asthmatic subjects. AU - Kohi, F.. AU - Miyagawa, H.. AU - Agrawal, Devendra K.. AU - Bewtra, Againdra K.. AU - Townley, R. G.. PY - 1990. Y1 - 1990. N2 - We determined the relationship of allergic disease to the number and activity of eosinophils and their production of leukotriene B4 and leukotriene C4 (leukotriene D4 equivalents). Granulocytes from allergic rhinitis (AR) subjects and asthmatics release more LTC4 than normals. Furthermore, eosinophils of astmatics generate more LTC4 than those of AR subjects.. AB - We determined the relationship of allergic disease to the number and activity of eosinophils and their production of leukotriene B4 and leukotriene C4 (leukotriene D4 equivalents). Granulocytes from allergic rhinitis (AR) subjects and asthmatics release more LTC4 than normals. Furthermore, eosinophils of astmatics generate more LTC4 than those of AR subjects.. UR - ...
TY - JOUR. T1 - Generation of leukotriene B4 and C4 from granulocytes of normal controls, allergic rhinitis, and asthmatic subjects. AU - Kohi, F.. AU - Miyagawa, H.. AU - Agrawal, D. K.. AU - Bewtra, A. K.. AU - Townley, R. G.. PY - 1990/1/1. Y1 - 1990/1/1. N2 - We determined the relationship of allergic disease to the number and activity of eosinophils and their production of leukotriene B4 and leukotriene C4 (leukotriene D4 equivalents). Granulocytes from allergic rhinitis (AR) subjects and asthmatics release more LTC4 than normals. Furthermore, eosinophils of astmatics generate more LTC4 than those of AR subjects.. AB - We determined the relationship of allergic disease to the number and activity of eosinophils and their production of leukotriene B4 and leukotriene C4 (leukotriene D4 equivalents). Granulocytes from allergic rhinitis (AR) subjects and asthmatics release more LTC4 than normals. Furthermore, eosinophils of astmatics generate more LTC4 than those of AR subjects.. UR - ...
leukotriene B4 71160-24-2 MSDS report, leukotriene B4 MSDS safety technical specifications search, leukotriene B4 safety information specifications ect.
TY - JOUR. T1 - Role of the BLT2, a leukotriene B4 receptor, in Ras transformation. AU - Yoo, Min Hyuk. AU - Song, Haiwon. AU - Woo, Chang Hoon. AU - Kim, HeungGyu. AU - Kim, Jae-Hong. PY - 2004/12/9. Y1 - 2004/12/9. N2 - Oncogenic Ras is known to drive both the Rac and Raf-MAP-kinase pathways, which act in concert to cause cell transformation. Unlike the Raf-MAP-kinase cascade, however, the downstream elements of Rac pathway are not fully understood. Previously, we showed that cytosolic phospholipase A2 (cPLA2) and subsequent metabolism of arachidonic acid act downstream of Rac to mediate the transformation signaling induced by Ha-RasV12. In the present study, we observed that leukotriene B4 (LTB 4) and its synthetic enzymes as well as BLT2, the low-affinity LTB4 receptor, are all elevated in Ha-RasV12-transformed cells. In addition, the malignant phenotypes of Ras-transformed cells were markedly inhibited by BLT2 blockade, as was their tumorigenicity in vivo. Finally, in situ hybridization ...
BioAssay record AID 102295 submitted by ChEMBL: Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes at a dose of 10 uM.
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Reactivity of the small and large airways to inhaled leucotriene D4, one of the leucotrienes that constitute slow reacting substance of anaphylaxis, was studied in eight patients with exogenous asthma and nine healthy subjects with no history of atopy. Non-cumulative dose response relations were constructed for leucotriene D4 in a randomised, double blind set up. Reactivity to the leucotriene was compared with reactivity to histamine in the two groups. Both groups reacted to leucotriene D4 with significant airway obstruction evident in forced expiratory volume in one second (FEV1), peak expiratory flow rate, maximal expiratory flow rate at 30% of forced vital capacity estimated from a partial flow volume curve initiated at 50% of vital capacity (V30), and an increase in volume of trapped gas. The airways of the patients were significantly (p less than 0.01) more reactive to leucotriene D4 than those of the controls. The differences were in order of magnitude, 10(2)-10(3) for FEV1 but only about ...
Leukotrienes (LT) are a group of proinflammatory lipid mediators that are implicated in the pathogenesis and progression of atherosclerosis. Here we report that mRNA levels for the three key proteins in LTB4 biosynthesis, namely 5-lipoxygenase (5-LO), 5-LO-activating protein (FLAP), and LTA4 hydrolase (LTA4H), are significantly increased in human atherosclerotic plaque (n = 72) as compared with healthy controls (n = 6). Neither LTC4 synthase nor any of the LT receptors exhibits significantly increased mRNA levels. Immunohistochemical staining revealed abundant expression of 5-LO, FLAP, and LTA4H protein, colocalizing in macrophages of intimal lesions. Human lesion tissue converts arachidonic acid into significant amounts of LTB4, and a selective, tight-binding LTA4H inhibitor can block this activity. Furthermore, expression of 5-LO and LTA4H, but not FLAP, is increased in patients with recent or ongoing symptoms of plaque instability, and medication with warfarin correlates with increased levels ...
Fig. 4 Enhanced phosphorylation of BLT1 by sequential exposure to increasing concentrations of LTB4.. (A) Intracellular [Ca2+] in HeLa cells expressing HA-BLT1/0N that were pretreated with 10 nM LTB4 or vehicle before being stimulated with 100 nM LTB4. The response to adenosine triphosphate (ATP) was included as a positive control. (B) HeLa cells expressing HA-BLT1/0N were stimulated with LTB4 as indicated. Membrane fractions were subjected to Phos-tag SDS-PAGE and immunoblotting for HA. WCLs were subjected to SDS-PAGE and immunoblotting for ERK1/2 and phosphorylated ERK1/2 (p-ERK1/2). β-Actin is an experimental and loading control. (C) RBL-2H3, CHO-K1, and Ba/F3 cells expressing HA-BLT1/0N were stimulated with LTB4 as indicated. Membrane fractions were separated by Phos-tag SDS-PAGE and immunoblotted for HA. (D) HeLa cells expressing HA-BLT1/0N were stimulated with LTB4 in the presence or absence of 100 nM CP105696 (CP) or ZK158252 (ZK). Membrane fractions were separated by Phos-tag SDS-PAGE ...
The early signalling events that may ultimately contribute to the assembly and subsequent activation of the NADPH oxidase in guinea-pig peritoneal eosinophils were investigated in response to leukotriene B4 (LTB4). LTB4 promoted a rapid, transient and receptor-mediated increase in the rate of H2O2 generation that was potentiated by R 59 022, a diradylglycerol (DRG) kinase inhibitor, implicating protein kinase C (PKC) in the genesis of this response. This conclusion was supported by the finding that the PKC inhibitor, Ro 31-8220, attenuated (by about 30%) the peak rate of LTB4-induced H2O2 generation under conditions where the same response evoked by 4 beta-phorbol 12,13-dibutyrate (PDBu) was inhibited by more than 90%. Paradoxically, Ro 31-8220 doubled the amount of H2O2 produced by LTB4 which may relate to the ability of PKC to inhibit cell signalling through phospholipase C (PLC). Indeed, Ro 31-8220 significantly enhanced LTB4-induced Ins(1,4,5)P3 accumulation and the duration of the Ca2+ ...
Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5791-4 ...
TSPO (Translocator 18KDa; tryptophan-rich sensory protein oxygen sensor) is a constitutive outer mitochondrial membrane protein overexpressed in inflammatory cells during local or systemic processes. Despite its expression is characterized, role of TSPO in inflammation remains elusive. For this study, we investigated the role of TSPO ligands on neutrophil functions elicited by two different inflammatory pathways. Peritoneal neutrophils were isolated from male Balb-C mice, treated with TSPO ligand diazepam, Ro5-4864 or PK11195 (1,100 or 1000nM; 2 hours) and further stimulated with lipopolysaccharide from Escherichia coli (LPS), a binding for Toll-Like Receptor-4 (TLR4), or leukotriene B4 (LTB4), a G-protein coupled receptor (GPCR) ligand. LPS treatment did not lead to overexpression of TSPO on neutrophils, and pre-treatment with any TSPO ligand did not alter cytokine expression, adhesion molecule expression, or the production of reactive oxygen and nitrogen species caused by LPS stimulation. Conversely,
Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
Several lines of evidence show that production of PGE2 is enhanced during inflammation, and this lipid mediator can dramatically modulate the immune response (43). Given these observations and because myeloid-derived cells produce large amounts of proinflammatory lipid mediators, we investigated COX expression, PGE2 synthesis, and cytokine production by BM-DC. We reported that production of AA-derived metabolites did not require the addition of exogenous substrate, because BM-DC are able to produce PGE2 and LTB4 under the two experimental conditions, and these APC express cytosolic PLA2, which catalyzes the release of endogenous AA from the cell membrane. The expression of cPLA2 is up-regulated by LPS in a dose-dependent fashion, and an important liberation of AA was observed in LPS-treated BM-DC compared with control cells. These data are consistent with previous studies, which reported induction of cPLA2 by LPS in human leukocytes (44, 45). Analysis of COX expression shows that resting BM-DC ...
The presence of specific leukotriene B4 (LTB4) binding sites was investigated in membranes prepared from mouse, rat, guinea pig and rabbit brain. Specific binding sites have been found in guinea pig brain membranes (GPBM) but not in the other species studied. Specific binding of LTB4 to GPBM was proportional to membrane concentration, saturable and reversible, reaching a steady-state suggesting equilibrium after 30 min of incubation. Analysis of the binding data showed a single binding site with a Kd = 2.27 +/- 0.55 nM and a Bmax = 576 +/- 89.6 fmol/mg protein. The relative potencies of LTB4 analogs to displace the tritiated ligand were LTB4 greater than 20-hydroxy-LTB4 much greater than 20-carboxy-LTB4 greater than 12-(S)hydroxy-5,8,10,14(Z,Z,E,Z)-eicosatetraenoic acid; LTD4 and LTC4 did not displace the ligand in concentrations up to 50 microM. The binding was inhibited by monovalent cations and GTP[gamma S] and increased by divalent cations. Specific binding was associated to the cerebral ...
BECA, T; HERNANDEZ, G y BASCONES, A. NSAIDs in the treatment of periodontal disease. Avances en Periodoncia [online]. 2007, vol.19, n.2, pp.101-113. ISSN 2340-3209.. SUMMARY A review about the application of antiinflammatories as an aid for the periodontal treatment is presented. After a brief introduction, we explain the immunological bases of periodontal inflamation and tissue destruction, focusing on arachidonic acid metabolism and the four most important inflammatory mediators now in periodontal tissue resorption: prostaglandin E2 (PGE2), prostaglandin F2a(PGF2a), leucotriene B4 (LTB4) and platelet activation factor (PAF), and explaining their actions and role in inflammation through matrix metalloproteinase (MMPs) and their relation with some other mediators in the inflammatory chain also related with tissue resorption. After, we expound some of the most used drugs for the inhibition of all of these mediators (non-steroid antiinflammatory drugs or NSAIDs, omega3 fatty acids, tetracyclines ...
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990 ...
Periodontal disease is a local inflammatory disease initiated by bacteria characterized by neutrophil-mediated tissue injury followed by development of a chronic immune lesion. In this study, we report the treatment of established periodontitis using RvE1 as a monotherapy in rabbits compared with structurally related lipids PGE(2) and leukotriene B(4). PGE(2) and leukotriene B(4) each enhanced development of periodontitis and worsened the severity of disease ...
The trial achieved its primary efficacy endpoint of demonstrating a reduction in one or more of these key biomarkers. The results showed that at all dose levels DG031 suppressed production of leukotriene B4 (LTB4), the product of the branch of the leukotriene pathway that deCODEs genetics research has linked to increased risk of heart attack. At the highest dose level, DG031 reduced levels of myeloperoxidase (MPO), higher levels of which have been linked to increased risk of heart attack. These effects were dose-dependent. The study also demonstrated that at the highest dose, DG031 lowered levels of sICAM-I, a critical molecule in the activation of inflammatory cells and cell infiltration. There were no serious drug-related adverse events reported in this study, and DG031 was found to be well tolerated.. Our population genetics work pointed us to the role of the leukotriene pathway and LTB4 in driving the inflammatory process underlying heart attack. DG031 is designed to inhibit the FLAP, or ...
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
LEUKOTRIENE A-4 HYDROLASE1h-indol-5-ol2-(3-amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic Acid5-hydroxyindoleBestatinImidazoleYtterbium (iii) IonZinc Ion
leukotriene: Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.
Spurred in part by the recommendation of a professor when working as an obstetrician and gynecologist, Prof. Yokomizo started research under Prof. Takao Shimizu, a leading expert in prostaglandin research. Initially his research focused on lipid metabolizing enzymes and then progressed to the mechanism of action of bioactive lipids. He then decided to challenge himself to do research into receptors during the preparation period for his overseas study. Since the research was to be done in such a short time before his overseas study, he attempted cloning of BLT1 cDNA using an unconventional method, a cDNA subtraction, and as a result, he discovered the gene for the leukotriene B4 (LTB4) receptor(1). LTB4 had been known to act as a potent chemotactic factor for neutrophils, eosinophils, and macrophages, but nobody had succeeded in identifying its receptor until his discovery. During a bacterial infection, neutrophils usually gather at the site of infection (known as swarming). Knocking out BLT1 ...
Leukotrienes,LTs,SRS-A,SRS,Leukotriene A4,Leukotriene A4,(2S,3S)-3-(1E,3E,5Z,8Z)-1,3,5,8-Tetradecatetraenyloxiranebutanoic acid,leukotriene A,LTA4,Leukotriene B4,Leukotriene B4,(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid,leukotriene B,LTB4,Leukotriene C4,Leukotriene C4,L-gamma-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinylglycine,leukotriene C,leukotriene C1,LTC4,Leukotriene D4,Leukotriene D4,S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinylglycine,leukotriene D,LTD4,Leukotriene E4,Leukotriene E4,(5S,6R,7E,9E,11Z,14Z)-6-[[(2R)-2-Amino-2-carboxyethyl]thio]-5-hydroxy-7,9,11,14-eicosatetraenoic acid,leukotriene E,LTE4
5-oxo-6-trans-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by w-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the w-carboxy position and after CoA ester formation. (PMID: 7649996 , 17623009 , 2853166 , ...
In this study, we provide biological mechanisms implicated in LTB4-mediated antiviral activity against in vivo as well as in vitro infection with influenza virus. We also demonstrate the potential implication of neutrophil secretion of antimicrobial peptides such as β-defensins, mEARs and CRAMP in a mouse model of infection and human LL-37 and EDN in such activity. These LTB4-mediated neutrophil activities also involve the high-affinity LTB4 receptor, BLT1.. This study clearly shows that administration of leukotriene B4 in mice infected with influenza virus helps controlling viral infection via the triggering of BLT1R receptor. The antiviral action mediated by LTB4 seems to involve the secretion of antimicrobial peptides in lung tissue. We demonstrated that neutrophils leave the bloodstream to mobilize in the infected tissue (in this case the lung) following LTB4 administration. These neutrophils are believed to secrete peptides known to possess antiviral properties such as defensins, CRAMP, ...
BioAssay record AID 101434 submitted by ChEMBL: Inhibition of leukotriene B4 (LTB4) binding to its receptor on intact human neutrophils.
Neutrophils are the first responders to sites of injury and infection, but their role in cancer is poorly understood. Human tumors, often likened to wounds that do not heal, can display extensive neutrophil infiltration. These neutrophils are recruited through chemoattraction, adhesion, and transendothelial migration, analogous to tumor cell extravasation during metastasis. In some contexts, neutrophils suppress tumors through cytotoxic action or the recruitment of tumor-specific T cells. In others, neutrophils can promote tumor progression by sustaining inflammation.. Wculek and Malanchi showed that neutrophils can act as the primary driver of metastatic colonization in a mouse model of breast cancer. First, neutrophils infiltrated the lungs and secreted proinflammatory lipid mediators (leukotrienes) that stimulate adhesion, chemotaxis, and vascular permeability. In turn, tumor cells with leukotriene receptors were recruited to the lungs, a phenotype correlated with enhanced metastatic ...
Non-resolving inflammation drives the development of clinically dangerous atherosclerotic lesions by promoting sustained plaque inflammation, large necrotic cores, thin fibrous caps, and thrombosis. Resolution of inflammation is not merely a passive return to homeostasis, but rather an active process mediated by specific molecules, including fatty acid-derived specialized pro-resolving mediators (SPMs). In advanced atherosclerosis, there is an imbalance between levels of SPMs and proinflammatory lipid mediators, which results in sustained leukocyte influx into lesions, inflammatory macrophage polarization, and impaired efferocytosis. In animal models of advanced atherosclerosis, restoration of SPMs limits plaque progression by suppressing inflammation, enhancing efferocytosis, and promoting an increase in collagen cap thickness. This Review discusses the roles of non-resolving inflammation in atherosclerosis and highlights the unique therapeutic potential of SPMs in blocking the progression of ...
Leukotriene A4 (LTA4) hydrolase [(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7, 9,11,14-tetraenoate hydrolase; EC 3.3.2.6] is a bifunctional zinc metalloenzyme that catalyzes the final step in the biosynthesis of the potent chemotactic agent leukotriene B4 (LTB4). LTA4 hydrolase/aminopeptidase is suicide inactivated during catalysis via an apparently mechanism-based irreversible binding of LTA4 to the protein in a 1:1 stoichiometry. Previously, we have identified a henicosapeptide, encompassing residues Leu-365 to Lys-385 in human LTA4 hydrolase, which contains a site involved in the covalent binding of LTA4 to the native enzyme. To investigate the role of Tyr-378, a potential candidate for this binding site, we exchanged Tyr for Phe or Gln in two separate mutants. In addition, each of two adjacent and potentially reactive residues, Ser-379 and Ser-380, were exchanged for Ala. The mutated enzymes were expressed as (His)6-tagged fusion proteins in Escherichia coli, purified to apparent homogeneity, and
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Deregulation of the oxidative cascade of poly-unsaturated fatty acids (PUFAs) has been associated with several cancers, including chronic lymphocytic leukemia (B-CLL). Leukotriene B4 (LTB4), a metabolite of arachidonic acid (AA), is produced by B-CLL and contributes to their survival. The aim of the present study was to analyze the activity of the oxidative cascade of PUFAs in B-CLL. Purified B cells from patients and normal B CD5 positive cells were subjected to flow cytometry, Western-blot and RT-qPCR analyses. LTB4 plasma and intracellular concentrations were determined by ELISA. Our results showed that aggressive B-CLL tumor cells, i.e. cells with an annual proliferation index above 2, over-expressed calcium-dependent and calcium-independent phospholipases A2 (cPLA2-alpha and iPLA2-beta, respectively), 5-lipoxygenase (5LOX) and leukotriene A4 hydroxylase (LTA4H). Intracellular LTB4 levels were lower in the most aggressive cells than in cells with a smaller proliferation index, despite equivalent
Homozygous mice for this leukotriene B4 receptor (|i|Ltb4r1|/i|, commonly referred to as BLTR) knock-out exhibit substantially diminished recruitment of eosinophils, effector T cells, and neutrophil; and may be useful for studying leukocyte function in inflammation, as well as the role of the LTB4-BLT1 pathway linking early immune system activation and multiple classes of acquired immune effector cells.
14,15-Leukotriene c4/ACM75290607 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Leukotriene B4 production by blood neutrophils in allergic rhinitis-effects of cetirizine (pages 729-736). S. CHERIA-SAMMARI, R. ALOUI, F. GORMAND, B. CHABANNES, H. GALLET, M. GROSCLAUDE, M. MELAC, J. P. RIHOUX, M. PERRIN-FAYOLLE, M. LAGARDE and Y. PACHECO. Version of Record online: 27 APR 2006 , DOI: 10.1111/j.1365-2222.1995.tb00010.x. ...
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pep: chromosome:VEGA66:11:50236472:50238616:-1 gene:OTTMUSG00000005578 transcript:OTTMUST00000012403 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Ltc4s description:leukotriene C4 synthase ...
The regulation of CD11b integrin levels on human blood leukocytes and leukotriene B4-stimulated skin by a specific leukotriene B4 receptor antagonist (LY293111 ...
TY - JOUR. T1 - Leptin promotes a proinflammatory lipid profile and induces inflammatory pathways in human SZ95 sebocytes. AU - Törocsik, D.. AU - Kovács, D.. AU - Camera, E.. AU - Lovászi, M.. AU - Cseri, K.. AU - Nagy, G. G.. AU - Molinaro, R.. AU - Rühl, R.. AU - Tax, G.. AU - Szabó, K.. AU - Picardo, M.. AU - Kemény, L.. AU - Zouboulis, C. C.. AU - Remenyik, PY - 2014/12/1. Y1 - 2014/12/1. N2 - Background Leptin, the adipocyte-secreted hormone that regulates weight, is known to link lipid metabolism with inflammation in various cell types. However, its role in human sebocytes has not yet been investigated. Objectives The purpose of this study was to investigate the effects of leptin in human sebaceous gland biology. Methods Expression of the long form of the leptin receptor (Ob-Rb) was detected by real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and immunochemistry. Lipid analysis was by high-performance thin-layer chromatography, gas chromatography-mass ...
A Polymorphonuclear Granulocyte is a type of white blood cell that has granules (=small particles) with enzymes in their cytoplasm. They are released during infections, allergic reactions, and asthma. Neutrophils, eosinophils, and basophils are polymorphonuclear granulocytes. They are called polymorphonuclear because of the varying shapes of their nucleus (usually lobed into 3 segments.) As you…
Of the three types of leukocytes recruited, neutrophils, eosinophils, and macrophages, the most striking difference between BLTR−/− and wild-type mice occurred in eosinophil recruitment (Fig. 5 A). Neither group had substantial numbers of peritoneal eosinophils at baseline or 4 h after thioglycollate instillation. Peak numbers of eosinophils were seen in both groups at 48 h, but BLTR−/− mice recruited only 33% as many eosinophils to the inflamed peritoneum as wild-type mice at this time point (P , 0.005). Numbers of peritoneal eosinophils declined in both groups at 96 h, but BLTR−/− mice continued to have significantly fewer of these cells. At 96 h, BLTR−/− mice had only 20% as many eosinophils recovered from the peritoneal cavity as wild-type mice (P , 0.01).. Although the numbers of peritoneal neutrophils and macrophages appeared lower in the BLTR−/− mice at some time points, the differences from wild type did not reach statistical significance for either of these cell ...
These findings point to a role of LTB4 in atherosclerosis and intimal hyperplasia, by identifying the vascular SMC as targets for this potent chemotactic molecule. The expression of the human BLT1 receptor on vascular SMC was demonstrated by immunohistochemical stainings of arterial samples, as well as in cultured human coronary SMC by Western blotting and RT-PCR. Together, these findings provide evidence that human vascular SMC express BLT1 receptors in vivo as well as in vitro, and they suggest that these cells may represent an additional target for LTB4.. Patch-clamp analysis and functional studies of SMC clarified that BLT1 receptors transduce a signal that leads to important functional responses in human vascular SMC. Membrane currents in human coronary artery SMC were increased significantly in the presence of either LTB4 or the selective BLT1 receptor partial agonist U75302. Also, another characteristic pharmacological feature of the BLT1 receptor (namely, its rapid desensitization by an ...
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase. Other names in common use include LTA4 hydrolase, LTA4H, and leukotriene A4 hydrolase. This enzyme participates in arachidonic acid metabolism. ...
This report by Pace and colleagues provides new insights into the influence of sex (and sex hormones) on leukotriene synthesis and its inhibition. While the potential of these results to be of clinical relevance is exciting, additional preclinical and clinical studies are needed to define the true clinical impact, which is likely to be complex. For example, Pace et al. focus primarily on inflammatory processes and leukocytes that predominantly generate LTB4. Although a number of inflammatory diseases, including scleroderma lung disease (13), inflammatory bowel disease (6), sickle cell disease (14), and cardiovascular disease (15), are reported to be associated with increased LTB4 levels, there are few, if any, examples in which treatment of these diseases with leukotriene synthesis inhibitors has shown benefit. The diseases in which there is the most information relevant to leukotriene biology are asthma, AERD, and allergic rhinitis, to which cysteinyl leukotrienes are known to contribute. For ...
A protocol has been produced for the study of anaphylactic accidents that occur post-operatively that allows definition of the anaphylactic origin, and so reactions that are mediated by IgE in post-operative accidents. This protocol occurs in two stages, the first is done in the minutes and hours that follow the anaphylactic accident, and the second a month or 6 weeks afterwards. At first, we evaluate the sequential study of the liberation of the mediators of anaphylaxis, plasma histamine, serum tryptase, urinary methylhistamine and, more recently, leucotriene E4. The second study is devoted to reactions that are mediated by IgE, essentially, specific serum IgE, tests of activation of basophils by flow cytometry, measurement of leucotriene C4 and skin tests. A study on 16 subjects has evaluated and validated the protocol and shown a significant level of correspondence of results between the sequential measurement of mediators on one hand and on the other the search for IgE-mediated reactions every time
article{a0090b47-94ce-453b-9412-f151ac7d6530, abstract = {The intestinal epithelial barrier, which is regulated by the actin cytoskeleton, exhibits permeability changes during inflammation. Here we show that activation of the CysLT(1) receptor by the inflammatory mediator leukotriene D-4 (LTD4) causes a rapid increase in stress-fibre formation in intestinal epithelial cells. This effect was mimicked by cytotoxic necrotising factor-1 (CNF-1)-induced activation of RhoA, overexpression of constitutively active RhoA (L63-RhoA) and phorbol-ester-induced activation of protein kinase C (PKC). In accordance, inhibition of RhoA, by C3 exoenzyme or by dominant-negative RhoA (N19-RhoA), as well as GF109203X-induced inhibition of PKC, suppressed the LTD4-induced stress-fibre formation. Introduction of the dominant-negative regulatory domain of PKCdelta, but not the corresponding structures from PKCalpha, betaII or epsilon, blocked the LTD4-induced stress-fibre formation. Evaluating the relationship between ...
Leukotrienes (LTs) are members of the eicosanoid family of bioactive signaling molecules derived from the substrate arachdonic acid (AA). LTs are lipid signalin...
Boswellia-C | Herbal Products | , Silverton, , Pretoria | Our Boswellia Capsules Alleviates Ulcerative Colitis And Crohnrsquo;s Disease. Reduces Inflammation By Suppressing The 5-Lipoxygenase Enzyme That Catalyzes The Endogenous Production Of The Inflammatory Elcosanoids, Lipoxins And Serie 4 Leukotrienes. Including Leukotriene B4. Stimulates The Differentiation Of Leukaemia Cells Back To Normal And Also Stimulates The Apoptosis Of Leukaemia Cells. Alleviate The Inflammation Associated With Fibrositis, Osteoarthritis Rheumatoid Arthritis And Reduce Stiffness And Tenderness Of Joints. Reduces And Improve Breathing Capacity In Asthma Patients. Alleviate The Inflammation Associated With Psoriasis. Ingredients: Boswellia.
These results demonstrate a novel pathway of aberrant regulation of PGP/AcPGP, suggesting this inflammatory pathway may be intimately involved in disease progression in the absence of ongoing cigarette smoke exposure. We highlight a mechanism by which acrolein potentiates neutrophilic inflammation t …
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... leukotriene B4, leukotriene C4, leukotriene D4, leukotriene E4, lipoxin A4, and lipoxin B4. It and other members of the 5-(S)- ... Leukotriene A4 may then be further metabolized either to leukotriene B4 by leukotriene A4 hydrolase or to leukotriene C4 by ... Finally, leukotriene C4 may be metabolized to leukotriene D4 and then to leukotriene E4. The relative amounts of these ... Since a previously discovered arachidonic acid metabolite made by neutrophils, leukotriene B4 (LTB4), also stimulates human ...
Leukotriene B4 receptor 2 Leukotriene B4 receptor 1 Leukotriene B4 12-Hydroxyeicosatetraenoic acid 15-hydroxyicosatetraenoic ... See 'Leukotriene B4 receptor 2 for the associations of BLT2 and/or 12-HHT with stimulating the malignant behavior of prostate ... Leukotriene B4 (i.e. LTB4) is an arachidonic acid metabolite made by the 5-lipoxygenase enzyme pathway. It activates cells ... Hicks, A; Monkarsh, S. P.; Hoffman, A. F.; Goodnow Jr, R (2007). "Leukotriene B4 receptor antagonists as therapeutics for ...
"Leukotriene B4 antagonism ameliorates experimental lymphedema". Science Translational Medicine. 9 (389): eaal3920. doi:10.1126/ ... "Modulation of pulmonary leukotriene formation and perfusion pressure by Bestatin, an inhibitor of leukotriene A4 hydrolase". ... It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays ... leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia and lymphedema. It is ...
"The Role of Leukotriene B4 in Allergic Diseases". Yokomizo T, Izumi T, Shimizu T (January 2001). "Leukotriene B4: metabolism ... CYP4F2 then coverts 20-hydroxyleukotriene B4 to 20-oxoleukotriene B4 and then to 20-carboxyleukotrene B4. It is α-, β-, and ω- ... Leukotriene B4 is a pro-inflammatory eicosanoid with strong chemoattractant properties. It can be rapidly produced by activated ... The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is ...
Leukotrienes: BLT1 (Leukotriene B4 receptor) - LTB4R; BLT1 is the primary receptor for leukotriene B4. Relative potencies in ... BLT2 (Leukotriene B4 receptor 2) - LTB4R2; the receptor for 12-Hydroxyheptadecatrienoic acid, leukotriene B4, and certain other ... CysLT1 (Cysteinyl leukotriene receptor 1) - CYSLTR1;CYSLTR1 is the receptor for Leukotriene C4 and Leukotriene D4; in binds and ... GPR17 - GPR17; while one study reported that leukotriene C4, leukotriene D4, and leukotriene E4 bind to and activate GPR17 with ...
Yokomizo, T. (2014). "Two distinct leukotriene B4 receptors, BLT1 and BLT2". Journal of Biochemistry. 157 (2): 65-71. doi: ...
A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase". J. Biol. Chem. 276 (44): 40803-10. doi ...
Kikuta Y, Kato M, Yamashita Y, Miyauchi Y, Tanaka K, Kamada N, Kusunose M (March 1998). "Human leukotriene B4 omega-hydroxylase ... cDNA cloning and expression of leukotriene B4 omega-hydroxylase". The Journal of Biological Chemistry. 268 (13): 9376-80. PMID ... March 2006). "Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: ... The hydroxylation-induced inactivation of the mediators of inflammation, perhaps particularly of leukotriene B4, may underlie ...
An antioxidant-type inhibitor of leukotriene B4 formation". Planta Medica. 60 (5): 410-3. doi:10.1055/s-2006-959520. PMID ...
In contrast, PPARα is activated by leukotriene B4. Certain members of the 15-hydroxyeicosatetraenoic acid family of arachidonic ...
Kumar KCS, Müller K (April 2000). "Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth, 2. ... 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism". J. Nat. Prod. 62 (6): 817-20. doi:10.1021/ ... As inhibitors of prostaglandin synthesis and leukotriene B4 biosynthesis, some depsides have in vitro anti-inflammatory ...
... activates the Leukotriene B4 receptor, Leukotriene B4 receptor 2 (BLT2) but not its Leukotriene B4 receptor 1 (BLT1). This ... GPR31 and the Leukotriene B4 receptor 2; 12S-HETE also acts as a receptor antagonist by binding to but not stimulating the ... HETE bind to and activate the Leukotriene B4 receptor 2, activate the Peroxisome proliferator-activated receptor gamma, and at ... "Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2". The Journal of Biological Chemistry. ...
15-leukotrienes B4) and to two isomeric erythro-14,15-dihydroxy-5-cis-8,10,12-eicosatetraenoic acids (14,15-leukotrienes B4). ... and Eoxin E4 and analogs of leukotriene A4, C4, leukotriene D4, and E4. Formation of the leukotrienes is initiated by 5- ... 15(S)-HpETE and 15(S)-HETE bind to and activate the G protein-coupled receptor, Leukotriene B4 receptor 2, i.e. BLT2. This ... "Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2". Journal of Biological Chemistry. 276 ( ...
"An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection". PLOS ONE. 8 (7): e67828 ... "Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous ...
Leukotriene B4, vis., Leukotriene B4 receptor 2 (BLT2), but not its Leukotriene B4 receptor 1, mediates responses to 12(S)-HETE ... "Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: Impact upon leukotriene B4- and 12( ... "Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: Impact upon leukotriene B4- and 12( ... Kim, G. Y.; Lee, J. W.; Cho, S. H.; Seo, J. M.; Kim, J. H. (2009). "Role of the low-affinity leukotriene B4 receptor BLT2 in ...
Prostaglandin E2 and inflammatory exudate are also reduced and leukotriene B4 is inhibited. Carprofen can also be given orally ...
It acts as a leukotriene B4 receptor antagonist and a PPARγ agonist. Clinical trials were conducted measuring efficacy for ... Adrian, T. E.; Hennig, R; Friess, H; Ding, X (2008). "The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in ...
"Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)". ...
Studies have shown that it does not inhibit 5-lipoxygenase and leukotriene B4, as originally claimed. It is therefore not ... Salman, JA; Tilling, LC; Monscada, S (1984). "Benoxaprofen does not inhibit formation of leukotriene B4 in a model of acute ...
It also inhibits the release of leukotriene B4 from monocytes after stimulation with bacterial lipopolysaccharides. It blocks ...
Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 ...
... an agonist of Leukotriene B4 receptors (i.e. BLT2 receptors) and mediator of certain BLT2 receptor actions. The enzyme plays a ... 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2". Journal of Experimental Medicine. 205 (4): 759-766. doi: ...
... has little activity in omega-hydroxylating leukotriene B4, prostaglandin D2, prostaglandin E2, prostaglandin E1, or ...
Synthesis of P-selectin can be induced by thrombin, leukotriene B4, complement fragment C5a, histamine, TNFα or LPS. These ...
... leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6". J Immunol. 171 (11 ... and of neutrophils to sites of injury in response to leukotriene B4. GRCh38: Ensembl release 89: ENSG00000198055 - Ensembl, May ...
"20-Hydroxylation is the CYP-dependent and retinoid-inducible leukotriene B4 inactivation pathway in human and mouse skin cells ... and this metabolism of certain bioactive arachidonic acid metabolites such as leukotriene B4, 5-hydroxyicosatetraenoic acid, ...
... which catalyzes the conversion of arachidonic acid to leukotriene B4 (LTB4). LTB4 promotes skin inflammation by acting on the ...
"G Protein Activation by the Leukotriene B4 Receptor Dimer". Mol. Biol. 329: 815. doi:10.1074/jbc.M710419200. ... aktiviranog leukotrienskog B4 receptora BLT1 i Giα2β1γ2 pentamerni sklop jednog dimernog receptora i heterotrimernog G proteina ...
6) CYP4F2, CYP4F3A, CYP4F3B, and CYP4F11 ω-hydroxylate leukotriene B4 and very probably 5-hydroxyeicosatetraenoic acid and 5- ...
... which catalyzes the conversion of arachidonic acid to leukotriene B4 (LTB4).[45] LTB4 promotes skin inflammation by acting on ...
... , also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.[3] It makes the eye appear pink or reddish.[1] Pain, burning, scratchiness, or itchiness may occur.[1] The affected eye may have increased tears or be "stuck shut" in the morning.[1] Swelling of the white part of the eye may also occur.[1] Itching is more common in cases due to allergies.[2] Conjunctivitis can affect one or both eyes.[1] The most common infectious causes are viral followed by bacterial.[2] The viral infection may occur along with other symptoms of a common cold.[1] Both viral and bacterial cases are easily spread between people.[1] Allergies to pollen or animal hair are also a common cause.[2] Diagnosis is often based on signs and symptoms.[1] Occasionally, a sample of the discharge is sent for culture.[1] Prevention is partly by handwashing.[1] Treatment depends on the underlying cause.[1] In the majority of viral cases, there is no ...
synthesized on demand: citokinin (IFN-γ, IL-8, TNF-α, IL-1) - eicosanoids (Leukotriene B4, Prostaglandins) - Nitrit oksida - ...
വിവരങ്ങൾ ക്രിയേറ്റീവ് കോമൺസ് ആട്രിബ്യൂഷൻ-ഷെയർഎലൈക്ക് അനുമതിപത്ര പ്രകാരം ലഭ്യമാണ്; മേൽ നിബന്ധനകൾ ഉണ്ടായേക്കാം. കൂടുതൽ വിവരങ്ങൾക്ക് ഉപയോഗനിബന്ധനകൾ കാണുക ...
... leukotriene A4 LTA4, which is then either rapidly converted to leukotriene B4 (LTB4) by Leukotriene-A4 hydrolase (LTA4H) or to ... Leukotriene-A4 hydrolase, to form the dihydroxyl product, Leukotriene B4 (LTB4, i.e. 5S,12R-dihydroxy-5S,6Z,8E,10E,12R,14Z- ... leukotriene metabolic process. • leukotriene production involved in inflammatory response. • leukotriene biosynthetic process. ... "The effect of n-3 polyunsaturated fatty acids on leukotriene B₄ and leukotriene B₅ production from stimulated neutrophil ...
മുഖക്കുരുവിനുള്ള ചികിത്സയിൽ ലോറിക് ആസിഡ് ഉൾപ്പെടെയുള്ള ചില ഫാറ്റി ആസിഡുകൾ ഉപയോഗപ്രദമാകുമെന്ന് വിട്രോ പരീക്ഷണങ്ങൾ സൂചിപ്പിക്കുന്നു, എന്നാൽ മനുഷ്യരിൽ ഈ സാധ്യതയുള്ള ഗുണം വിലയിരുത്തുന്നതിന് ഇതുവരെ ക്ലിനിക്കൽ പരീക്ഷണങ്ങളൊന്നും നടത്തിയിട്ടില്ല.[13][14] ലോറിക് ആസിഡ് മറ്റ് പല ഫാറ്റി ആസിഡുകളേക്കാളും മൊത്തം സെറം കൊളസ്ട്രോൾ വർദ്ധിപ്പിക്കുന്നു, പക്ഷേ ഉയർന്ന സാന്ദ്രതയുള്ള ...
... is an inflammation of the bronchi (large and medium-sized airways) in the lungs.[1] Symptoms include coughing up mucus, wheezing, shortness of breath, and chest discomfort.[1] Bronchitis is divided into two types: acute and chronic.[1] Acute bronchitis is also known as a chest cold.[1] Acute bronchitis usually has a cough that lasts around three weeks.[4] In more than 90% of cases the cause is a viral infection.[4] These viruses may be spread through the air when people cough or by direct contact.[1] Risk factors include exposure to tobacco smoke, dust, and other air pollution.[1] A small number of cases are due to high levels of air pollution or bacteria such as Mycoplasma pneumoniae or Bordetella pertussis.[4][5] Treatment of acute bronchitis typically involves rest, paracetamol (acetaminophen), and NSAIDs to help with the fever.[6][7] Chronic bronchitis is defined as a productive cough that lasts for three months or more per year for at least two years.[8] Most people with chronic ...
Leukotriene signaling modulators. Nuclear receptor modulators. "https://ml.wikipedia.org/w/index.php?title=പ്രോസ്റ്റാഗ്ലാൻഡിൻ_ ...
Leukotriene signaling modulators. Prostanoid signaling modulators. Retrieved from "https://en.wikipedia.org/w/index.php?title= ...
... which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase.[4] ... Leukotriene A4 hydrolase, also known as LTA4H is a human gene.[1][2][3] The protein encoded by this gene is a bifunctional ... Other names in common use include LTA4 hydrolase, LTA4H, and leukotriene A4 hydrolase. This enzyme participates in arachidonic ... leukotriene A4 hydrolase. Crystallographic structure of LTA4H (rainbow colored N-terminus = blue, C-terminus = red) complexed ...
... in amino acid sequence and functionality to chemotactic factor receptors such as the receptors for C5a and leukotriene B4.[2] ...
... leukotriene B4 and serotonin mediated release of eosinophil granules occur, complement complex (C5-C6-C7), interleukin 5, and ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
... is inflammation of the brain.[5] Severity is variable.[1] Symptoms may include headache, fever, confusion, a stiff neck, and vomiting.[1] Complications may include seizures, hallucinations, trouble speaking, memory problems, and problems with hearing.[1] Causes of encephalitis include viruses such as herpes simplex virus and rabies as well as bacteria, fungi, or parasites.[1][2] Other causes include autoimmune diseases and certain medications.[2] In many cases the cause remains unknown.[2] Risk factors include a weak immune system.[2] Diagnosis is typically based on symptoms and supported by blood tests, medical imaging, and analysis of cerebrospinal fluid.[2] Certain types are preventable with vaccines.[5] Treatment may include antiviral medications (such as acyclovir), anticonvulsants, and corticosteroids.[1] Treatment generally takes place in hospital.[1] Some people require artificial respiration.[1] Once the immediate problem is under control, rehabilitation may be required.[2] ...
Sagittal magnetic resonance images of ankle region: psoriatic arthritis. (a) Short tau inversion recovery (STIR) image, showing high signal intensity at the Achilles tendon insertion (enthesitis, thick arrow) and in the synovium of the ankle joint (synovitis, long thin arrow). Bone marrow oedema is seen at the tendon insertion (short thin arrow). (b, c) T1 weighted images of a different section of the same patient, before (panel b) and after (panel c) intravenous contrast injection, confirm inflammation (large arrow) at the enthesis and reveal bone erosion at tendon insertion (short thin arrows ...
Leukotriene B4, and H2O2[9] in a process called chemotaxis. They are the predominant cells in pus, accounting for its whitish/ ... and Leukotriene B4, which these cells use to direct the path of their migration. ...
They also inactivate or reduce the activity of signaling molecules: they metabolize leukotriene B4 (LTB4) to 20-hydroxy-LTB4, 5 ...
Agonists: Leukotriene C4. *Leukotriene D4. *Leukotriene E4. *Antagonists: Ablukast ...
The focus of treatment is to remove plaque. Therapy is aimed at the reduction of oral bacteria and may take the form of regular periodic visits to a dental professional together with adequate oral hygiene home care. Thus, several of the methods used in the prevention of gingivitis can also be used for the treatment of manifest gingivitis, such as scaling, root planing, curettage, mouth washes containing chlorhexidine or hydrogen peroxide, and flossing. Interdental brushes also help remove any causative agents. Powered toothbrushes work better than manual toothbrushes in reducing the disease.[15] The active ingredients that "reduce plaque and demonstrate effective reduction of gingival inflammation over a period of time" are triclosan, chlorhexidine digluconate, and a combination of thymol, menthol, eucalyptol, and methyl salicylate. These ingredients are found in toothpaste and mouthwash. Hydrogen peroxide was long considered a suitable over-the-counter agent to treat gingivitis. There has been ...
... and leukotriene-5 eicosanoids. EPA is both a precursor and the hydrolytic breakdown product of eicosapentaenoyl ethanolamide ( ... b4-3-,7-6-,10-9-,13-12-,16-15- Y ...
A lumbar puncture is done by positioning the person, usually lying on the side, applying local anesthetic, and inserting a needle into the dural sac (a sac around the spinal cord) to collect cerebrospinal fluid (CSF). When this has been achieved, the "opening pressure" of the CSF is measured using a manometer. The pressure is normally between 6 and 18 cm water (cmH2O);[42] in bacterial meningitis the pressure is usually elevated.[8][41] In cryptococcal meningitis, intracranial pressure is markedly elevated.[45] The initial appearance of the fluid may prove an indication of the nature of the infection: cloudy CSF indicates higher levels of protein, white and red blood cells and/or bacteria, and therefore may suggest bacterial meningitis.[8] The CSF sample is examined for presence and types of white blood cells, red blood cells, protein content and glucose level.[8] Gram staining of the sample may demonstrate bacteria in bacterial meningitis, but absence of bacteria does not exclude bacterial ...
Breast cancer may coincide with or mimic symptoms of mastitis. Only full resolution of symptoms and careful examination are sufficient to exclude the diagnosis of breast cancer. Lifetime risk for breast cancer is significantly reduced for women who were pregnant and breastfeeding. Mastitis episodes do not appear to influence lifetime risk of breast cancer. Mastitis does however cause great difficulties in diagnosis of breast cancer and delayed diagnosis and treatment can result in worse outcome. Breast cancer may coincide with mastitis or develop shortly afterwards. All suspicious symptoms that do not completely disappear within 5 weeks must be investigated. Breast cancer incidence during pregnancy and lactation is assumed to be the same as in controls. Course and prognosis are also very similar to age matched controls.[26][27] However diagnosis during lactation is particularly problematic, often leading to delayed diagnosis and treatment. Some data suggest that noninflammatory breast cancer ...
In both the acute and chronic forms, antibiotics are used if an infection is suspected. The treatment of choice is often azithromycin and cefixime to cover both gonorrhoeae and chlamydia. Fluoroquinolones are no longer recommended due to widespread resistance of gonorrhoeae to this class.[7] Doxycycline may be used as an alternative to azithromycin. In chronic epididymitis, a four- to six-week course of antibiotics may be prescribed to ensure the complete eradication of any possible bacterial cause, especially the various chlamydiae. For cases caused by enteric organisms (such as E. coli), ofloxacin or levofloxacin are recommended.[7] In children, fluoroquinolones and doxycycline are best avoided. Since bacteria that cause urinary tract infections are often the cause of epididymitis in children, co-trimoxazole or suited penicillins (for example, cephalexin) can be used. Household remedies such as elevation of the scrotum and cold compresses applied regularly to the scrotum may relieve the pain ...
Nonallergic rhinitis refers to rhinitis that is not due to an allergy. The category was formerly referred to as vasomotor rhinitis, as the first cause discovered was vasodilation due to an overactive parasympathetic nerve response. As additional causes were identified, additional types of nonallergic rhinitis were recognized. Vasomotor rhinitis is now included among these under the more general classification of nonallergic rhinitis.[14] The diagnosis is made upon excluding allergic causes.[15] It is an umbrella term of rhinitis of multiple causes, such as occupational (chemical), smoking, gustatory, hormonal, senile (rhinitis of the elderly), atrophic, medication-induced (including rhinitis medicamentosa), local allergic rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES) and idiopathic (vasomotor or non-allergic, non-infectious perennial allergic rhinitis (NANIPER), or non-infectious non-allergic rhinitis (NINAR).[16]. In vasomotor rhinitis,[17][18] certain nonspecific stimuli, ...
... refers to an underlying process that causes inflammation and injury of the heart. It does not refer to inflammation of the heart as a consequence of some other insult. Many secondary causes, such as a heart attack, can lead to inflammation of the myocardium and therefore the diagnosis of myocarditis cannot be made by evidence of inflammation of the myocardium alone.[20][21] Myocardial inflammation can be suspected on the basis of electrocardiographic (ECG) results, elevated C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR), and increased IgM (serology) against viruses known to affect the myocardium. Markers of myocardial damage (troponin or creatine kinase cardiac isoenzymes) are elevated.[11] The ECG findings most commonly seen in myocarditis are diffuse T wave inversions; saddle-shaped ST-segment elevations may be present (these are also seen in pericarditis).[11] The gold standard is the biopsy of the myocardium, in general done in the setting of angiography. A ...
Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of ... elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic ...
Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice ... Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory ... A study at the University of California, San Diego School of Medicine has shown that leukotriene B4 promotes insulin resistance ... It is synthesized by leukotriene-A4 hydrolase from leukotriene A4. ...
Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma. ...
The leukotriene B4 receptors (BLTRs) include the following two receptors: Leukotriene B4 receptor 1 (BLTR1) Leukotriene B4 ... receptor 2 (BLTR2) Eicosanoid receptor Leukotriene receptor v t e. ...
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... Enhanced levels of leukotriene B4 in synovial fluid in Lyme disease. E. Mayatepek,1 D. Hassler,2 and M. Maiwald3 ... E. Mayatepek, D. Hassler, and M. Maiwald, "Enhanced levels of leukotriene B4 in synovial fluid in Lyme disease," Mediators of ...
Abcam provides specific protocols for Anti-Leukotriene B4 Receptor antibody (ab82851) : Western blot protocols, ...
Rabbit polyclonal Leukotriene B4 Receptor antibody validated for WB, ICC/IF and tested in Human. With 1 independent review. ... Anti-Leukotriene B4 Receptor antibody. See all Leukotriene B4 Receptor primary antibodies. ... All lanes : Anti-Leukotriene B4 Receptor antibody (ab82851) at 1 µg/ml. Lane 1 : Human thyroid normal tissue lysate - total ... Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human Leukotriene B4 Receptor. Read Abcams ...
Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators ... Retrieved from "https://www.wikidoc.org/index.php?title=Leukotriene_B4&oldid=718197" ... Patient Handouts on Leukotriene B4 Directions to Hospitals Treating Leukotriene B4 Risk calculators and risk factors for ... Review articles on Leukotriene B4 Articles on Leukotriene B4 in N Eng J Med, Lancet, BMJ ...
Leukotriene B4 ~100 μg/mL in ethanol, ≥97%; CAS Number: 71160-24-2; EC Number: 200-578-6; Synonyms: [5S,12R]-Dihydroxy-[6Z,8E, ... Leukotriene B4 formation during human neutrophil keratinocyte interactions: evidence for transformation of leukotriene A4 by ... keratinocytes were coincubated with human neutrophils to determine whether or not an increase in leukotriene B4 formation can ... This compound is featured on the Leukotriene Receptors and Nuclear Receptors (PPARs) pages of the Handbook of Receptor ...
Leukotriene B4 (LTB4) has been implicated in prostate and colon carcinogenesis, but little is known about the potential role of ... Leukotriene B4 / antagonists & inhibitors, metabolism*. Lipoxygenase Inhibitors / pharmacology. Male. Nordihydroguaiaretic Acid ... 20937254 - Role of leukotriene b4 in celecoxib-mediated anticancer effect.. 18573234 - A role for sirt1 in cell growth and ...
Leukotriene B4 antagonism ameliorates experimental lymphedema Message Subject. (Your Name) has forwarded a page to you from ... Leukotriene B4 antagonism ameliorates experimental lymphedema. By Wen Tian, Stanley G. Rockson, Xinguo Jiang, Jeanna Kim, ... Leukotriene B4 antagonism ameliorates experimental lymphedema. By Wen Tian, Stanley G. Rockson, Xinguo Jiang, Jeanna Kim, ... examined the role that leukotriene B4 (LTB4) plays in acquired lymphedema. LTB4 was elevated in patient serum and was ...
Leukotriene B4 receptor, also known as LTB4R, is a human gene.[1] ... 1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis". Nature. 387 (6633): 620-4. doi:10.1038/42506 ... Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor". ... Receptors,+Leukotriene+B4 at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Browse our Leukotriene B4 Receptor 2 Lysate catalog backed by our Guarantee+. ... Leukotriene B4 Receptor 2 Lysates available through Novus Biologicals. ... Leukotriene B4 Receptor 2 Lysates. We offer Leukotriene B4 Receptor 2 Lysates for use in common research applications: Western ... Alternate Names for Leukotriene B4 Receptor 2 Lysates. Leukotriene B4 Receptor 2 lysate, LTB4R2 lysate, BLT2LTB4 receptor JULF2 ...
Browse our Leukotriene B4 R1 product catalog backed by our Guarantee+. ... Leukotriene B4 R1 products available through Novus Biologicals. ... Leukotriene B4 R1 Antibodies (8). Leukotriene B4 R1 Lysate (1) ... PTMs for Leukotriene B4 R1. Learn more about PTMs related to Leukotriene B4 R1.. Phosphorylation. Methylation. Carboxylation. ... Diseases related to Leukotriene B4 R1. Discover more about diseases related to Leukotriene B4 R1.. Inflammation. Asthma. ...
Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function ... Leukotriene B; Leukotriene B-4; Leukotrienes B; 5,12 HETE; 5,12 diHETE; B-4, Leukotriene; Leukotriene B 4; 5,12-HETE; 5,12- ... Leukotriene B4. Subscribe to New Research on Leukotriene B4 The major metabolite in neutrophil polymorphonuclear leukocytes. It ... leukotriene B4 is produced in the gut mucosa during ischemia and reperfusion, and (b) inhibition of leukotriene B4 attenuates ...
Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. Lundeen, K.A., Sun, B., ... Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid ... Role of the BLT2, a leukotriene B4 receptor, in Ras transformation. Yoo, M.H., Song, H., Woo, C.H., Kim, H., Kim, J.H. Oncogene ... Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells. Obinata, H ...
Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4.. Beeh KM1, ... The present study was designed to assess the contribution of interleukin (IL)-8 and leukotriene B(4) (LTB(4)) to neutrophil ...
... ... Mariana Trivilin Mendes and Paulo Flavio Silveira, "The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase ...
Find Leukotriene B4 Receptor 1 research area related information and Leukotriene B4 Receptor 1 research products from R&D ... Leukotriene B4 Receptor 1. Leukotriene B4 R1 (LTB4R1) is a seven transmembrane G-protein-coupled receptor that is highly ... It is a receptor for Leukotriene B4, an arachidonic acid metabolite that is a potent chemoattractant involved in inflammation ...
Mechanisms of Leukotriene B4-Triggered Monocyte Adhesion. Erik B. Friedrich, Andrew M. Tager, Emerson Liu, Annika Pettersson, ... Mechanisms of Leukotriene B4-Triggered Monocyte Adhesion. Erik B. Friedrich, Andrew M. Tager, Emerson Liu, Annika Pettersson, ... Mechanisms of Leukotriene B4-Triggered Monocyte Adhesion. Erik B. Friedrich, Andrew M. Tager, Emerson Liu, Annika Pettersson, ...
2014) Targeting leukotriene B4 in inflammation. Expert Opin Ther Targets 18(1):79-93. ... 2011) Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are ... 2007) Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in ... 2003) Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc Natl Acad Sci USA 100( ...
Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4 ... Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4 ... Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4 ... Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4 ...
Leukotriene B4 was detected in all five individuals, an ... To investigate whether leukotriene B4 is present in the ... Leukotriene B4 was detected in all five individuals, and its identity was confirmed by a combination of high pressure liquid ... To investigate whether leukotriene B4 is present in the arterial blood of asthmatic patients during wheezing attacks, 20 ml of ... The concentration of leukotriene B4 was 48.34 +/- 16.27 pg ml-1 (mean value +/- SE). However, in five control subjects the ...
Leukotriene B4 signaling through NF-κB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal ... which are activated by leukotrienes C4, D4, and E4; and BLT receptors, which are activated by leukotriene B4 (LTB4) (2, 3). The ... Leukotriene B4 signaling through NF-κB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal ... Leukotriene B4 signaling through NF-κB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal ...
anti-Leukotriene B4 Receptor antibody (FITC) Leukotriene B4 Receptor antibody (FITC). Details for Product No. ABIN119613, ... Leukotriene B4 receptor 1, P2RY7, P2Y purinoceptor 7, P2Y7 ... anti-Leukotriene B4 Receptor 2 Antibodies * anti-Leukotriene C4 ... "First-generation monoclonal antibodies identifying the human leukotriene B(4) receptor-1." in: Biochemical and biophysical ...
A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation ... Leukotriene B4 Receptors (Leukotriene B4 Receptor). Subscribe to New Research on Leukotriene B4 Receptors ... Leukotriene B4 Receptor; Receptors, Leukotriene B4; LTB4 Receptor; Receptor, LTB4; Receptor, Leukotriene B4; Receptors, LTB4; ... A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation ...
Phagocytosis and bactericidal action of mouse peritoneal macrophages treated with leukotriene B4. Int. J. Immunopharmacol. 11: ... Leukotriene B4 Induces Release of Antimicrobial Peptides in Lungs of Virally Infected Mice ... Leukotriene B4 Protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation ... A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387: 620-624. ...
Release of prostaglandin E2 and leukotriene B4 by alveolar macrophages from patients with sarcoidosis. ... Release of prostaglandin E2 and leukotriene B4 by alveolar macrophages from patients with sarcoidosis. ... and leukotriene B4 (LTB4). Alveolar macrophages were cultured in the presence or absence of opsonised zymosan (500 micrograms/ ...
NADP-dependent leukotriene B4 12-hydroxydehydrogenase. A, B. 333. Cavia porcellus. Mutation(s): 0 Gene Names: Ptgr1, Ltb4dh. EC ... The crystal structure of the ternary complex of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin (15-oxo-PG) 13- ... The crystal structure of the ternary complex of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin (15-oxo-PG) 13- ... Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13- ...
Rabbit Polyclonal Leukotriene B4 Receptor antibody. Validated in IHC-P, IHC-Fr. Tested in Human, Mouse, Rat, Rabbit, Hamster, ... leukotriene B4 receptor , BLT1 , BLTR , CMKRL1 , GPR16 , LTB4R , LTB4R1 , LTBR1 , P2RY7 , P2Y7 , Leukotriene B4 Receptor ... There are currently no reviews for Leukotriene B4 Receptor antibody (GTX71031). Be the first to share your experience with this ... There are currently no references for Leukotriene B4 Receptor antibody (GTX71031). Be the first to share your publications with ...
  • Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. (wikipedia.org)
  • Leukotriene B4 (LTB4) has been implicated in prostate and colon carcinogenesis, but little is known about the potential role of LTB4 in celecoxib-mediated anticancer effect. (biomedsearch.com)
  • BLTR2, also known as Leukotriene B4 Receptor 1, is a Chemoattractant Receptor that causes LTB4-induced chemotaxis, calcium mobilization, and inhibition of adenylyl cyclase. (novusbio.com)
  • METHODS: Alveolar macrophages recovered from the bronchoalveolar lavage (BAL) fluid of 32 patients with sarcoidosis in different states of disease activity and 10 normal subjects were evaluated for their ability to release prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). (bmj.com)
  • Analysis of alpha 1AT-deficient macrophage supernates by reverse-phase HPLC, molecular sieve chromatography, radioimmunoassay, and absorption with anti-LTB4 antibody revealed that the majority of the chemotactic activity was leukotriene B4 (LTB4), a mediator absent from normal macrophage supernates. (nih.gov)
  • In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. (sigmaaldrich.com)
  • The presence of specific leukotriene B4 (LTB4) binding sites was investigated in membranes prepared from mouse, rat, guinea pig and rabbit brain. (aspetjournals.org)
  • The inflammatory process was studied in patients with an acute exacerbation of COPD in order to ascertain the role of leukotriene B4 (LTB4). (ersjournals.com)
  • Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. (lu.se)
  • 2 h) and further stimulated with lipopolysaccharide from Escherichia coli (LPS), a binding for Toll-Like Receptor-4 (TLR4), or leukotriene B4 (LTB4), a G-protein coupled receptor (GPCR) ligand. (frontiersin.org)
  • Upon BLTR (Leukotriene B receptor) activation by LTB4 (leukotriene B4), the coupled G-protein dissociates in two subunits. (frontiersin.org)
  • 5-oxo-6-trans-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). (hmdb.ca)
  • The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. (hmdb.ca)
  • The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. (nii.ac.jp)
  • The early signalling events that may ultimately contribute to the assembly and subsequent activation of the NADPH oxidase in guinea-pig peritoneal eosinophils were investigated in response to leukotriene B4 (LTB4). (biochemj.org)
  • Leukotriene B4 (LTB4) is a lipid mediator that acts as a potent chemoattractant for inflammatory leukocytes. (nih.gov)
  • Human polymorphonuclear (PMN) leukocytes bound [3H]leukotriene B4 ([3H]-LTB4) specifically, as assessed by the displacement of 88% or more of the bound radioactivity by a 15,000-fold higher concentration of nonradioactive LTB4 or by micromolar concentrations of structural isomers of LTB4. (rupress.org)
  • Background: Polymorphisms spanning genes involved in the production of leukotriene B4 (LTB4) e.g. (worktribe.com)
  • and (b) Gene expression analysis of human peripheral blood mononuclear cell (PBMCs) cultured with macrophage colony-stimulating factor (M-CSF), or M-CSF + leukotriene B4 (LTB4), for 8 or 14 days, showing the differential expression of nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), cathepsin K, tartrate-resistant acid phosphatase (TRAP), matrix metalloproteinase 9 (MMP9) and β 3 integrin. (biomedcentral.com)
  • Results: AA treatment stimulated the synthesis of leukotriene B4 (LTB4) and HETE-8, but lowered the levels of prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), and HETE-5 in MDA-MB-231 cells. (eurekaselect.com)
  • We hypothesized that leukotrine B4 (LTB4) and LTB4-induced accumulation of leukocytes in the lung play a role in MCT-induced lung disease, and therefore measured LTB4 and myeloperoxidase (MPO) levels in lung tissue of MCT- treated rats. (elsevier.com)
  • The predominant proinflammatory leukotriene released from neutrophils is LTB4, which serves as a biological marker of inflammation. (oregonstate.edu)
  • Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation, implicated in numerous diseases including atherosclerosis. (omicsdi.org)
  • Leukotriene B4 (LTB4) is an important pro-inflammatory lipid mediator generated by neutrophils upon activation. (omicsdi.org)
  • The role of B4 Leukotriene (LTB4) in keloid pathogenesis particularly in the inflammation phase and tissue proliferation has not been clearly elucidated. (scirp.org)
  • Leukotriene B4 (LTB4) is one of the derivative of arachidonic acid that plays the role as lipid mediumtor of inflammation and fibroblast chemoattractant. (scirp.org)
  • Granulocyte-like PLB cells, but not granulocyte-like PLB-D cells, secreted leukotriene B4 (LTB4) after stimulation with ionomy- cin or A23187. (bgu.ac.il)
  • Objective: Two potent mediators of acute inflammation, histamine and leukotriene B4 (LTB4), have been shown to play important roles in the pathogenesis and clinical course of acute otitis media (AOM) in children. (utmb.edu)
  • Leukotriene B4 (LTB4) in fibroblast supernatants was detected with enzyme immunoassays, expression of 5-lipoxygenase (5-LOX) messenger RNA (mRNA) in skin fibroblasts was examined by reverse transcriptase-polymerase chain reaction and expression of 5-LOX protein was measured by immune blotting and immunofluorescent staining with rabbit anti-human 5-LOX antibody. (bioone.org)
  • ATLANTA, GA - Celtaxsys, Inc., a clinical stage pharmaceutical development company focused on advancing treatments for patients with rare inflammatory diseases, announced today the issuance of four new patents, extending its leadership position in development of a robust pipeline of inhibitors of Leukotriene A4 Hydrolase (LTA4H), the key rate limiting enzyme in production of the inflammatory mediator Leukotriene B4 (LTB4). (celtaxsys.com)
  • It is a novel small molecule inhibitor of Leukotriene A4 Hydrolase (LTA4H), the key enzyme in the production of the potent inflammatory mediator Leukotriene B4 (LTB4). (celtaxsys.com)
  • Studies in both humans and rodents have suggested that CD8 + T cells contribute to the development of airway hyperresponsiveness (AHR) and that leukotriene B4 (LTB4) is involved in the chemotaxis of effector CD8 + T cells (T EFF ) to the lung by virtue of their expression of BLT1, the receptor for LTB4. (elsevier.com)
  • Leukotriene B4 ( LTB4 ) has been discovered as a strong chemotactic factor, which plays a role in neutrophil migration. (bvsalud.org)
  • O leucotrieno B4 ( LTB4 ) foi descoberto como um forte fator quimiotático, que desempenha um papel na migração de neutrófilos . (bvsalud.org)
  • This compound is featured on the Leukotriene Receptors and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. (sigmaaldrich.com)
  • Leukotriene B 4 (LTB 4 ), a potent leukocyte chemoattractant derived from the 5-lipoxygenase metabolism of arachidonic acid, exerts its action by means of specific cell surface receptors, denoted BLT 1 and BLT 2 . (pnas.org)
  • and BLT receptors, which are activated by leukotriene B 4 (LTB 4 ) ( 2 , 3 ). (pnas.org)
  • Although these studies implicate leukotrienes in the pathogenesis of atherosclerosis, the role of LTB 4 and BLT receptors in atherogenesis is not clear. (pnas.org)
  • A class of cell surface leukotriene receptors with a preference for leukotriene B4. (curehunter.com)
  • Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. (rupress.org)
  • Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. (genecards.org)
  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. (genecards.org)
  • Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. (abcam.com)
  • It is a receptor for Leukotriene B4, an arachidonic acid metabolite that is a potent chemoattractant involved in inflammation and immune responses. (rndsystems.com)
  • Leukotriene B 4 (LTB 4 ) is a lipid mediator of inflammation that was recently shown to exert antiviral activities. (jimmunol.org)
  • Leukotriene B 4 (LTB 4 ) 3 is a potent lipid mediator of inflammation synthesized predominantly by leukocytes of the myeloid lineage such as monocytes/macrophages and neutrophils ( 1 ). (jimmunol.org)
  • Leukotrienes (LTs) are lipid mediators of inflammation derived from the 5-LO pathway of arachidonic acid metabolism. (bloodjournal.org)
  • 15-Lipoxygenase (LO) plays a central role in the "class switch" of eicosanoid mediator biosynthesis from leukotrienes to lipoxins, initiating the active resolution of inflammation. (ersjournals.com)
  • Leukotrienes follow and are typified by leukotriene B 4 (LTB 4 ) which amplifies and propagates inflammation [ 1 ]. (ersjournals.com)
  • Leukotrienes are potent biological mediators of inflammation generated from arachidonic acid via the 5-lipoxygenase pathway ( 1 )( 2 ). (rupress.org)
  • Neutrophils are involved in inflammation through leukotriene (LT) production. (oregonstate.edu)
  • Leukotriene B4 is a potent inflammation lipid mediumtor. (scirp.org)
  • BLT2 is a low-affinity receptor for leukotriene B 4 (LTB 4 ), a potent lipid mediator of inflammation generated from arachidonic acid via the 5-lipoxygenase pathway. (elsevier.com)
  • This antibody recognises the BLTR molecule, the leukotriene B4 receptor. (antibodies-online.com)
  • Recognizes the human BLTR molecule, the leukotriene B4 receptor. (lsbio.com)
  • 2000. BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis [see comments] J Exp Med 192(3):439-46. (jax.org)
  • The present study was designed to assess the contribution of interleukin (IL)-8 and leukotriene B(4) (LTB(4)) to neutrophil chemotaxis evoked by sputum obtained from patients with established COPD. (nih.gov)
  • We evaluated the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on chemotaxis to leukotriene B 4 in guinea pig peritoneal eosinophils. (elsevier.com)
  • Leukotriene B4 R1 (LTB4R1) is a seven transmembrane G-protein-coupled receptor that is highly expressed in lymphoid tissues and has been designated BLT1 according to the NC-IUPHAR nomenclature. (rndsystems.com)
  • LXA 4 was 100-fold less potent than leukotriene B 4 (LTB 4 ) and it elicited only one-half of the maximal response of LTB 4 . (portlandpress.com)
  • Leukotriene B 4 (LTB 4 ) is a potent chemoattractant active on multiple leukocytes, including neutrophils, macrophages, and eosinophils, and is implicated in the pathogenesis of a variety of inflammatory processes. (rupress.org)
  • CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B 4 (LTB 4 ) receptor antagonist. (aspetjournals.org)
  • cysteinyl leukotrienes (CysLTs), which are potent bronchoconstrictors, and the dihydroxy leukotriene, leukotriene B 4 (LTB 4 ) a chemoattractant and activator of leukocytes. (biomedcentral.com)
  • Background: Leukotriene B 4 (LTB 4 ) is a potent inflammatory lipid mediator that binds to LTB 4 receptor 1 (BLT1). (elsevier.com)
  • IHC-P analysis of human pancreas, carcinoma and leukocytes tissue using GTX71031 Leukotriene B4 Receptor antibody. (genetex.com)
  • IHC-P analysis of brain, alzheimer's, senile plaque tissue using GTX71031 Leukotriene B4 Receptor antibody. (genetex.com)
  • IHC-P analysis of brain, amygdala, neurons and glia tissue using GTX71031 Leukotriene B4 Receptor antibody. (genetex.com)
  • IHC-P analysis of human lymph node, hodgkins lymphoma tissue using GTX71031 Leukotriene B4 Receptor antibody. (genetex.com)
  • There are currently no references for Leukotriene B4 Receptor antibody (GTX71031) . (genetex.com)
  • BLT1 antibody LS-C44287 is an unconjugated mouse monoclonal antibody to human BLT1 (Leukotriene B4 Receptor). (lsbio.com)
  • 2000). "A second leukotriene B(4) receptor, BLT2. (wikidoc.org)
  • In the present study, we observed that leukotriene B 4 (LTB 4 ) and its synthetic enzymes as well as BLT2, the low-affinity LTB 4 receptor, are all elevated in Ha-Ras V12 -transformed cells. (elsevier.com)
  • It is synthesized by leukotriene-A4 hydrolase from leukotriene A4. (wikipedia.org)
  • Leukotriene B4 formation during human neutrophil keratinocyte interactions: evidence for transformation of leukotriene A4 by putative keratinocyte leukotriene A4 hydrolase. (sigmaaldrich.com)
  • Leukotriene A4 hydrolase and leukotriene B4 metabolism. (sigmaaldrich.com)
  • Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. (sigmaaldrich.com)
  • Mariana Trivilin Mendes and Paulo Flavio Silveira, "The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats," BioMed Research International , vol. 2014, Article ID 730421, 9 pages, 2014. (hindawi.com)
  • Leukotriene (LT) B 4 is a product of the action of LTA 4 hydrolase (LTA 4 -H) on LTA 4 in 5-lipoxygenase (5-LO) pathway. (biomedcentral.com)
  • abstract = "Eosinophil accumulation induced by leukotriene B4 appears to be involved in the pathogenesis of allergic diseases. (elsevier.com)
  • We show that the therapeutic benefit of ketoprofen is specifically attributable to its inhibition of the 5-lipoxygenase metabolite leukotriene B 4 (LTB 4 ). (sciencemag.org)
  • 4 Leukotriene B 4 (LTB 4 ), an arachidonic acid metabolite that is strongly chemotactic for neutrophils and monocytes/macrophages, 5 has been implicated as an initiator of EIU in studies using rats. (bmj.com)
  • Patients with Sjögren-Larsson syndrome accumulate leukotriene B4 and its omega-hydroxy metabolite, which are probably responsible for the pruritus seen in this disease. (medscape.com)
  • Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. (uniprot.org)
  • Endogenous production of leukotriene has been shown to be protective during the early phases of experimental vesicular stomatitis virus-mediated encephalitis ( 12 ). (jimmunol.org)
  • We determined the relationship of allergic disease to the number and activity of eosinophils and their production of leukotriene B 4 and leukotriene C 4 (leukotriene D 4 equivalents). (elsevier.com)
  • To investigate the relationship between mechanical stress and the production of leukotriene B(4) (LTB(4)) and NO, explants of porcine articular cartilage were subjected to mechanical compression for 1 h followed by 23 h recovery in the presence or absence of the NOS2 inhibitor 1400W. (duke.edu)
  • To determine whether inhibition of the migration of interphotoreceptor retinoid binding protein (IRBP)-specific autoreactive T cells and non-specific inflammatory cells by specific leukotriene B 4 (LTB 4 ) antagonist CP-105, 696 could inhibit established EAU. (arvojournals.org)
  • Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. (nih.gov)
  • Inhibition of in vitro leukotriene B4 biosynthesis in human neutrophil granulocytes and docking studies of natural quinones. (sigmaaldrich.com)
  • These findings suggest that leukotriene B4 contributes to neutrophil influx into the airway in chronic obstructive pulmonary disease and may influence disease progression. (ersjournals.com)
  • Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation. (rupress.org)
  • Role of leukotriene B4 in celecoxib-mediated anticancer effect. (biomedsearch.com)
  • Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. (nih.gov)
  • Leukotriene B4 receptor , also known as LTB4R , is a human gene . (wikidoc.org)
  • Leukotriene B4 receptor (LTB4R) is receptor that participates in defense against infection. (lsbio.com)
  • MBS2885130 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Leukotriene B4 receptor 1 (Ltb4r) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • 19342668 ). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (By similarity). (uniprot.org)
  • The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. (genecards.org)
  • CYSLTR2 (Cysteinyl Leukotriene Receptor 2) is a Protein Coding gene. (genecards.org)
  • Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and cysteinyl leukotriene receptor activity . (genecards.org)
  • Receptor for cysteinyl leukotrienes. (genecards.org)
  • The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leukotriene B 4 (LTB 4 ), whereas, in theory, cytoplasmic 5-LOX could favor the biosynthesis of proresolving lipoxin A 4 (LXA 4 ). (pnas.org)
  • Leukotriene B4 and asthma. (bmj.com)
  • Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma. (bmj.com)
  • These results suggest that leukotriene B4 may be important in elucidation of the pathogenesis of bronchial asthma. (biomedsearch.com)
  • In humans, several biomarkers, including hydrogen peroxide (H 2 O 2 ), pH and leukotriene B 4 (LTB 4 ) have proven useful for the detection and monitoring of inflammatory lung diseases, including asthma and chronic obstructive pulmonary disease. (edu.au)
  • Leukotriene B4 in equine asthma syndrome: what do we know so far? (bvsalud.org)
  • Optimization of assay conditions for leukotriene B4 synthesis by neutrophils or platelets isolated from peripheral blood of monogastric animals. (oregonstate.edu)
  • Release of prostaglandin E2 and leukotriene B4 by alveolar macrophages from patients with sarcoidosis. (bmj.com)
  • The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). (hmdb.ca)
  • Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. (hmdb.ca)
  • Prostaglandins Leukotrienes and Essential Fatty Acids , 58 (3), 243-248. (elsevier.com)
  • In the present study, keratinocytes were coincubated with human neutrophils to determine whether or not an increase in leukotriene B4 formation can occur. (sigmaaldrich.com)
  • Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action. (harvard.edu)
  • Leukotriene is synthesized mainly by leukocytes and different types of cells by means of trancelullar me- tabolism including neutrophils, platelets and vascular cells. (scirp.org)
  • The release kinetics of histamine and leukotriene C 4 (LTC 4 ) and B 4 (LTB 4 ) were investigated in nasal secretions of 10 patients with hay fever after antigen challenge. (elsevier.com)
  • A major role for the leukotriene pathway in vascular disease was suggested by studies of a congenic mouse strain demonstrating resistance to atherosclerosis linked to a locus on chromosome 6, within which the gene for 5-LO was mapped subsequently ( 12 ). (pnas.org)
  • Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. (hmdb.ca)
  • However, when free AA was additionally provided, a strong activation of the 5-lipoxygenase pathway was demasked, with the appearance of excessive quantities of leukotriene (LT)B4, LTA4, and 5-hydroxyeicosatetraenoic acid. (rupress.org)
  • Leukotriene (LT) D4 contributes to aberrant cytokine networks of classical Hodgkin lymphonoma, This study has investigated LTD4 induced gene expression and pathway in Hodgkin lymphonma cell line L1236. (omicsdi.org)
  • Discover related pathways, diseases and genes to Leukotriene B4 R1. (novusbio.com)
  • Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al. (lsbio.com)
  • Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. (lu.se)
  • Leukotriene B 4 (LTB 4 ) receptor type 1 (BLT1) is abundant in phagocytic and immune cells and plays crucial roles in various inflammatory diseases. (elsevier.com)
  • Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). (nih.gov)
  • The chemotactic and chemokinetic responses of eosinophils to leukotriene 3, were measured using a 96-well microchemotaxis chamber. (elsevier.com)
  • A prime example is RvD1's ability to decrease the ratio of proinflammatory leukotriene B 4 (LTB 4 ) to proresolving lipoxin A 4 (LXA 4 ), but the mechanism is not known. (pnas.org)
  • Endogenous leukotriene production was also shown to be an important event in innate defense as suggested by Bailie et al. (jimmunol.org)
  • Leukotrienes are eicosanoids. (hmdb.ca)
  • Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human Leukotriene B4 Receptor. (abcam.com)
  • Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Leukotriene B4 Receptor. (genetex.com)
  • Overall design: Human Hodgkin lymphoma cells are treated with Leukotriene (LT) D4 for 1 hour and 8 hour respectively, the expression profile are compared to non-treated control cells and methanol treated vihicle controls at the two time points. (omicsdi.org)
  • Yan Yan , Baoxi Wang , Ya-gang Zuo , and Tao Qu "Inhibitory Effects of Mizolastine on Ultraviolet B-Induced Leukotriene B4 Production and 5-Lipoxygenase Expression in Normal Human Dermal Fibroblasts In Vitro ," Photochemistry and Photobiology 82(3), 665-669, (1 May 2006). (bioone.org)
  • Crystal structure of human leukotriene B4 12-hydroxydehydrogenase in complex with NADP and raloxifene. (uniprot.org)
  • A study at the University of California, San Diego School of Medicine has shown that leukotriene B4 promotes insulin resistance in obese mice. (wikipedia.org)
  • In the latter study, it was shown that mice lacking the gene for 5-LO are protected from aortic aneurysms ( 18 ), supporting that leukotrienes may exert their effects on vascular cells producing structural elements. (pnas.org)
  • Specific binding sites for leukotriene B4 in guinea pig brain membranes. (aspetjournals.org)