Drug Evaluation
Antineoplastic Combined Chemotherapy Protocols
Drug Administration Schedule
Leukocyte Count
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Fluorouracil
Infusions, Intravenous
Paclitaxel
Treatment Outcome
Doxorubicin
Antineoplastic Agents, Phytogenic
Blood Cell Count
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Combined Modality Therapy
Cellophane
A generic name for film produced from wood pulp by the viscose process. It is a thin, transparent sheeting of regenerated cellulose, moisture-proof and sometimes dyed, and used chiefly as food wrapping or as bags for dialysis. (Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Nausea
Taxoids
Leukocytes
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Phlebovirus
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Menogaril
Dose-Response Relationship, Drug
Ehrlichia
Granulocyte Colony-Stimulating Factor
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Camptothecin
Ehrlichiosis
A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.
Levamisole
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Survival Rate
Mycophenolic Acid
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Leucovorin
Nogalamycin
Disease-Free Survival
Azathioprine
Carcinoma, Small Cell
Carcinoma, Non-Small-Cell Lung
Remission Induction
Neoplasms
Maximum Tolerated Dose
Neoplasm Metastasis
Ifosfamide
Antineoplastic Agents, Alkylating
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Pneumonia, Staphylococcal
Granulocytes
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Methotrexate
Pancytopenia
Mechlorethamine
Salvage Therapy
Neoplasm Recurrence, Local
Tegafur
Neoplasm Staging
Infusions, Parenteral
6-Mercaptopurine
Chemotherapy, Adjuvant
Ovarian Neoplasms
Ehrlichia chaffeensis
Prospective Studies
Epothilones
Epirubicin
Interferon-alpha
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Platinum
Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
Increase of hematopoietic responses by triple or single helical conformer of an antitumor (1-->3)-beta-D-glucan preparation, Sonifilan, in cyclophosphamide-induced leukopenic mice. (1/834)
It has been suggested that the immunopharmacological activity of soluble (1-->3)-beta-D-glucan depends on its conformation in mice. In this study, we examined the relationship between the conformation of Sonifilan (SPG) and hematopietic responses in cyclophosphamide (Cy)-induced leukopenic mice. SPG, a high molecular weight (1-->3)-beta-D-glucan, has a triple helical conformation in water, and it was changed by treatment with aqueous sodium hydroxide to the single helical conformer (SPG-OH). The effects of SPG or SPG-OH on hematopoietic responses in cyclophosphamide induced leukopenic mice were investigated by monitoring i) gene expression of cytokines by RT-PCR, ii) protein synthesis of interleukin 6 (IL-6) by ELISA and iii) colony formation of bone marrow cells (BMC). The mice administered Cy and SPG or SPG-OH expressed and produced higher levels of IL-6 mRNA and protein than the mice administered only Cy. Gene expression of NK1.1 was also induced by Cy/SPG (or SPG-OH) treatment. Induced gene expression of stem cell factor (SCF) and macrophage-colony stimulating factor (M-CSF) by SPG/SPG-OH were also found in in vitro culture of BMC from Cy treated mice. These results strongly suggested that conformation of the glucans, single and triple helix, are independent of the hematopietic response. (+info)A phase I/II study of continuous intra-arterial chemotherapy using an implantable reservoir for the treatment of liver metastases from breast cancer: a Japan Clinical Oncology Group (JCOG) study 9113. JCOG Breast Cancer Study Group. (2/834)
BACKGROUND: Liver metastasis from breast cancer has a poor prognosis. While there are some reports of good response rates of hepatic metastasis from breast cancer by hepatic intra-arterial infusion chemotherapy, no phase I study including pharmacokinetic analysis has been reported. We performed a phase I/II study of intra-arterial infusion chemotherapy using adriamycin and 5-fluorouracil to find the maximum tolerated dose and response rate in patients with advanced or recurrent breast cancer. METHODS: A hepatic arterial catheter with an access port was inserted into the proper hepatic artery. Patients received 30 mg/m2 adriamycin on days 1 and 8 and 100 mg/m2 5-fluorouracil at level 1, 200 mg/m2 at level 2,300 mg/m2 at level 3 and 400 mg/m2 at level 4 continuously from day 1 through day 14 every 28 days. At least two cycles were required before evaluation. Twenty-eight patients were entered into this study and 26 patients were evaluable. Seventeen patients had hepatic metastasis only, although nine patients had additional metastasis to other sites. RESULTS: Dose-limiting toxicity of thrombocytopenia and neurotoxicity occurred at level 4. Leukocytopenia (ECOG grade 3-4) was observed in five (19%), thrombocytopenia in three (12%) and anemia in two (8%) patients. There were 11 catheter-related complications which were not dose dependent. Seven out of 13 evaluable patients (54%) responded at level 3. The median duration of response was 5.8 months (range, 1-23+) and median survival was 25.3 months (range, 6.2-54.7+). CONCLUSION: Hepatic arterial infusion therapy appears to be safe and effective but catheter-related complications must be overcome before starting a phase III trial. (+info)Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide. (3/834)
Rats pretreated with traces of LPS developed acute fatal shock syndrome after i.v. administration of a mAb that inhibits the function of a membrane complement regulatory molecule. Such a shock was not observed after the administration of large amounts of LPS instead of the mAb following LPS pretreatment. The lethal response did not occur in rats depleted of either leukocytes or complement, and a C5a receptor antagonist was found to inhibit the reaction. Furthermore, LPS-treated rats did not suffer fatal shock following the injection of cobra venom factor, which activates complement in the fluid phase so extensively as to exhaust complement capacity. Therefore, complement activation on cell membranes is a requirement for this type of acute reaction. (+info)Quantitative and qualitative effects of cyclophosphamide administration on circulating polymorphonuclear leucocytes. (4/834)
The effect of cyclophosphamide (CY) on the absolute numbers and function of polymorphonuclear leucocytes (PMN) surviving in the circulation following either a single dose (100 mg/kg, i.p.) or daily administration (20 mg/kg, i.p., for 5 days) was studied in the guinea-pig. The quantitative effect of CY on peripheral blood leucocytes was assessed by measuring the absolute numbers of neutrophils, lymphocytes, and monocytes daily for 5 days following the initial injection of CY. The qualitative effects of CY on PMN function were determined by measuring the ability of these cells to function as killer cells. The two functional assays employed were the PMN-mediated PHA-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) assays against chicken erythrocyte targets. Both regimens of CY administration produced an equivalent degree of leukopenia 5 days after the initial injection with disproportionately severe neutropenia (less than 300 PMN/mm3). However, neither regimen of CY administration produced a significant decrease in cytotoxic effector function as measured through a wide range of effector to target cell ratios, PHA concentrations, and antiserum dilutions. These findings have clinical relevance in that they demonstrate the dichotomy between the quantitative and qualitative effects of (CY) on PMNs in that CY administration can dramatically decrease the absolute numbers of circulating polymorphonuclear leucocytes while leaving intact certain effector cell functional capabilities of those PMN surviving in the circulation during drug administration. (+info)Lithium dosage and leukocyte counts in psychiatric patients. (5/834)
OBJECTIVE: To evaluate differences in leukocyte counts among patients treated with either lithium alone, antipsychotic medications alone, or a combination of both. DESIGN: Retrospective study. SETTING: Long-stay psychiatric hospital. PATIENTS: Patients admitted between 1990 and 1993, and treated with lithium for at least 1 week and/or with antipsychotic medication for at least 2 weeks. Excluded from the study were those patients for whom complete blood counts at baseline and during therapy were not available, and those patients whose blood picture could primarily be accounted for by extraneous factors. Included in the study were 38 patients treated with lithium alone, 207 patients receiving antipsychotic medications alone, and 71 patients receiving both. OUTCOME MEASURES: Leukocyte, lymphocyte and granulocyte counts. RESULTS: Patients treated with lithium alone had significantly higher mean leukocyte and granulocyte counts than those treated with antipsychotic medication alone (analysis of variance, p < 0.05). None of the patients receiving lithium alone showed leukopenia. The dosage of lithium was significantly correlated with leukocyte count (r = 0.25, 95% confidence interval [CI] 0.14 to 0.35, p < 0.001,) and granulocyte count (r = 0.27, 95% CI 0.16 to 0.38, p < 0.001), but not with lymphocyte count (r = 0.06, p = 0.286, 95% CI -0.05 to 0.17). CONCLUSIONS: Lithium therapy is associated with higher leukocyte and granulocyte levels in psychiatric patients. This leukocytotic effect of lithium may be dose dependent. (+info)Phase I study of a biweekly schedule of a fixed dose of cisplatin with increasing doses of paclitaxel in patients with advanced oesophageal cancer. (6/834)
We performed this dose-finding study with a fixed dose of cisplatin and increasing doses of paclitaxel given every 2 weeks to determine the maximum tolerable dose of this schedule. Sixty-four patients with advanced oesophageal cancer were treated with a cisplatin dose of 60 mg m(-2) and increasing doses of paclitaxel from 100 mg m(-2) up to 200 mg m(-2) both administered over 3 h for a maximum of six cycles in patients with stable disease or eight cycles in responding patients. Patients were retreated when the granulocytes were > 0.75 x 10(9) l(-1) and the platelets > 75 x 10(9) l(-1). The dose of paclitaxel could be increased to 200 mg m(-2) without encountering dose limiting haematological toxicity. At the dose levels 190 mg m(-2) and 200 mg m(-2) of paclitaxel cumulative sensory neurotoxicity became the dose-limiting toxicity. The dose intensity of paclitaxel calculated over six cycles rose from 50 mg m(-2) per week to 85 mg m(-2) per week. Only three episodes of granulocytopenic fever were encountered out of a total of 362 cycles of treatment. Of the 59 patients evaluable for response, 31 (52%) had a partial or complete response. In a biweekly schedule with a fixed dose of 60 mg m(-2) cisplatin it is possible to increase the dose of paclitaxel to 180 mg m(-2). At higher dose levels, neurotoxicity becomes the dose-limiting toxicity. The observed response rate warrants further investigation of this schedule. (+info)Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. (7/834)
The histological identification of increased eosinophils in the gastrointestinal tract occurs in numerous clinical disorders; however, there is a limited understanding of the mechanisms regulating eosinophil trafficking into this mucosal surface. The results presented in this study characterize the processes regulating eosinophil homing into the gastrointestinal tract at baseline. Eosinophils were found to be present in the lamina propria of 19-day-old embryos and germ-free adult mice at concentrations comparable to those present in non-germ-free adult mice. Furthermore, eosinophil gastrointestinal levels were not altered by increasing circulating eosinophils after pulmonary allergen challenge. Gastrointestinal eosinophil levels were partially reduced in mice deficient in recombinase activating gene-1 (RAG-1), IL-5, or the beta common chain (betac), but these reductions paralleled reductions in circulating eosinophils. In contrast, mice deficient in eotaxin had a marked reduction in gastrointestinal eosinophils but normal levels of eosinophils in the hematopoietic compartments. Furthermore, eotaxin was important for regulating eosinophil levels, even in the presence of high levels of IL-5. These investigations demonstrate eosinophil homing into the gastrointestinal tract during embryonic development occurring independently of viable intestinal flora. Furthermore, eotaxin is identified as the primary regulator of eosinophil gastrointestinal homing under homeostatic states, and may therefore have a fundamental role in innate immune responses. (+info)Prevention of febrile leucopenia after chemotherapy in high-risk breast cancer patients: no significant difference between granulocyte-colony stimulating growth factor or ciprofloxacin plus amphotericin B. (8/834)
In a prospective randomized trial, 40 stage IV breast cancer patients undergoing intermediate high-dose chemotherapy (cyclophosphamide, 5-fluorouracil plus epirubicin or methotrexate), received either recombinant human G-CSF (rhG-CSF, group I) or ciprofloxacin and amphotericin B (CAB, group II) for prevention of febrile leucopenia (FL). In group I, seven of 18 patients developed FL (after 10/108 courses); in group II, seven of 22 patients (7/98 courses) (P = NS). Median hospitalization duration and costs were not different. RhG-CSF was 6.6 times more expensive per course than CAB. In conclusion, prophylactic CAB has similar efficacy to rhG-CSF in this setting, and is more cost-effective. (+info)
The response of peripheral lymphocytes of nude mice and leucopenic hyb by L Korcakova and M Holub
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Leukopenia
Minocycline, a commonly prescribed antibiotic, is another drug known to cause leukopenia. There are also reports of leukopenia ... Leukopenia can be identified with a complete blood count. Below are blood reference ranges for various types leucocytes/WBCs. ... Leukopenia (from Greek λευκός (leukos) 'white', and πενία (penia) 'deficiency') is a decrease in the number of leukocytes (WBC ... The terms leukopenia and neutropenia may occasionally be used interchangeably, as the neutrophil count is the most important ...
Bioremediation of radioactive waste
Leukopenia. Growth reduction. Reproductive deficiencies: sterility, reduction in fecundity, and occurrence of developmental ...
Protriptyline
... leukopenia;thrombocytopenia; purpura; eosinophilia. Gastrointestinal: Nausea and vomiting; anorexia; epigastric distress; ...
Sicilian phlebovirus
Marked leukopenia may occur. Patients may also experience transient diarrhea or constipation with abdominal discomfort. The ...
Brucella
Hematological signs include anemia, leukopenia, and thrombocytopenia. Brucella is isolated from a blood culture on Castaneda ...
Lamotrigine
... has been associated with a decrease in white blood cell count (leukopenia). Lamotrigine does not prolong QT/QTc in ... Nicholson RJ, Kelly KP, Grant IS (February 1995). "Leucopenia associated with lamotrigine". BMJ. 310 (6978): 504. doi:10.1136/ ...
Pestivirus
Symptoms of pestivirus infections include leukopenia and immunosuppression. In the pathogenesis of pestiviruses, ERNS is ...
Complete blood count
A decreased white blood cell count, termed leukopenia, can lead to an increased risk of acquiring infections, and occurs in ... Sepsis is associated with both leukocytosis and leukopenia. The total white blood cell count is usually reported in cells per ...
Toxic megacolon
Severe sepsis may present with hypothermia or leukopenia.[citation needed] Perforation of the colon Sepsis Shock Emergency ...
Management of Crohn's disease
The rare side effects include leukopenia or pancreatitis. There may also be an increased risk of lymphoma that is associated ...
Human monocytotropic ehrlichiosis
Laboratory abnormalities include thrombocytopenia, leukopenia, and elevated liver tests.[citation needed] The severity of the ...
White blood cell
A decrease below the lower limit is called leukopenia. This indicates a weakened immune system. The name "white blood cell" ... leukopenias). Leukocytosis is usually healthy (e.g., fighting an infection), but it also may be dysfunctionally proliferative. ...
PGM3 deficiency
Additionally, patients have significant leukopenia, lymphopenia, neutropenia, and eosinophilia. Mild defects in T-cell function ...
VEGFR-2 inhibitor
Other side effects are mild hypertension, leukopenia and bleeding. Uncommon side effects are cardiac ischaemia or infarction, ...
Cirrhosis
Leukopenia and neutropenia are due to splenomegaly with splenic margination.[citation needed] Coagulation defects occur, as the ...
Borrelia miyamotoi
Some patients may have elevated liver transaminases, thrombocytopenia, and leukopenia. Cases involving an erythema migrans rash ...
Fumarase deficiency
Laboratory findings in neonates may indicate polycythemia, leukopenia, or neutropenia. As they age, neurological deficits begin ...
Batai orthobunyavirus
Symptoms are characterized by fever, vomiting, diarrhea, thrombocytopenia and leukopenia. SFTS virus has a 6-30% fatality rate ...
Palbociclib
Leukopenia and anemia are also frequent among patients taking palbociclib. More than 10% of patients also experience side ...
Nivalenol
The mice fed for one year with nivalenol (also with the lower doses) were affected with severe leukopenia whereas the mice fed ... In rats and mice nivalenol showed to be toxic with adverse effects of growth retardation and leukopenia already noticed at ... 3,5 mg/kg bw) showed significant erythropenia and slight leukopenia. The subchronic toxicity was tested by feeding mice with a ... Long-term exposure may result in erythropenia and/or leukopenia. In mice it was also observed that nivalenol increased the ...
Lymphocytic choriomeningitis
In all reported cases, the initial symptoms included fever, lethargy, anorexia and leukopenia, and quickly progressed to ... Pathological findings during the first stage consist of leukopenia and thrombocytopenia. During the second phase, typical ...
Ehrlichiosis ewingii infection
Laboratory tests may reveal thrombocytopenia, leukopenia, and evidence of liver damage.[citation needed] Humans contract the ...
Tranilast
Given systemically it inhibits blood formation, causing leukopenia, thrombocytopenia, and anemia. As of March 2018 it was ...
Trichothecene
The onset of leukopenia, or reduction of white blood cell count, can be treated with a plasma or platelet transfusion. ... The second stage is characterized by leukopenia, granulopenia, and progressive lymphocytosis. The third stage is characterized ...
Lobaplatin
Common side effects include agranulocytosis, thrombocytopenia, anaemia, leukopenia, nausea and vomiting. Lobaplatin was first ...
Gaucher's disease
Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia. The brain and nervous system are ... Hypersplenism and pancytopenia, the rapid and premature destruction of blood cells, leads to anemia, neutropenia, leukopenia, ...
Pyrimethamine
Hematologic side effects such as thrombocytopenia, leukopenia, and anemia can also occur. Other antifolate agents such as ...
NUDT15
June 2016). "NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD". The ... Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. ... September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nature Genetics ... September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nature Genetics ...
Monocytopenia
... is a form of leukopenia associated with a deficiency of monocytes. It has been proposed as a measure to predict ...
Autoimmune disease
Leukopenia). For proper diagnosis, further testing is needed. A test used to measure levels of a protein group of the immune ...
Leukopenia
Leukocytosis and Leukopenia. The normal adult leukocyte count ranges from approximately 4,000 to 10,000 cells/mm3. Consequently ... The most common causes of leukopenia are recent infection, chemotherapy, radiation therapy, and HIV (Merck 2012a), but it can ... Leukopenia is a common side effect of anti-cancer drugs, as such drugs attack rapidly dividing cells (including neutrophils) ( ... The majority of cases of leukopenia are actually neutropenia since neutrophils constitute the majority of leukocytes. As the ...
Histoplasmosis | Leukopenia Disease
Leukopenia can be caused through use of some drugs or through other health problems. Causes Leukopenia Disease Mentioned below ... There are many causes Leukopenia Disease but let us first know what leucopenia is? When there is an abnormal reduction in the ... Leukopenia, malaria, menstrual period, myelofibrosis, rheumatoid arthritis, sepsis, sjogrens syndrome, Systematic Lupus ...
leukopenia Archives - Alpine Acupuncture
Tag Archives: leukopenia. Five Ways to Increase White Blood Cell Count with TCM. By admin , Published October 2, 2017 ... Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. ... Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. This condition may make those ...
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leukopenia Archives - Acupuncture Medical Center, PC
Tag Archives: leukopenia. Five Ways to Increase White Blood Cell Count with TCM. By admin , Published October 2, 2017 ... Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. ... Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. This condition may make those ...
leukopenia Archives - My Health is My Life
Tag Archives: leukopenia. Five Ways to Increase White Blood Cell Count with TCM. By admin , Published October 2, 2017 ... Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. ... Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. This condition may make those ...
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Leukopenia, Neutropenia and Agranulocytosis. In clinical trial and postmarketing experience, events of leukopenia/neutropenia ... Patients with a pre-existing low WBC or a history of drug induced leukopenia/neutropenia should have their complete blood count ... Possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell count (WBC) and history of drug ... Routine blood counts are advisable during therapy since blood dyscrasias including leukopenia, agranulocytosis, ...
These highlights do not include all the information needed to use SAPHRIS (asenapine) safely and effectively. See full...
17.9 Leukopenia/Neutropenia. Patients with a pre-existing low WBC or a history of drug induced leukopenia/neutropenia should be ... 5.9 Leukopenia, Neutropenia, and Agranulocytosis. In clinical trial and postmarketing experience, events of leukopenia/ ... 5.9 Leukopenia, Neutropenia, and Agranulocytosis 5.10 QT Prolongation 5.11 Hyperprolactinemia 5.12 Seizures 5.13 Potential for ... 17.9 Leukopenia/Neutropenia 17.10 Interference with Cognitive and Motor Performance 17.11 Heat Exposure and Dehydration 17.12 ...
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IMSEAR at SEARO: The Incidence of Clozapine-induced Leukopenia in schizophrenic patients at Roiet Hospital
... leukopenia and neutropenia.The incidence rate of leukopenia and neutropenia was 1.72 and the incidence density of leukopenia ... The Incidence of Clozapine-induced Leukopenia in schizophrenic patients at Roiet Hospital. ... further study should be made to gather more data to determine the association between risk factors and leucopenia,neutropenia ... and agranulocytosis in patients with schizophrenia and factors associated with leukopenia should be studied.In this study was ...
What is Leukopenia - Definition (ICD 10), Causes, Symptoms, Treatment (December 2021)
Leukopenia symptoms. What are the signs and symptoms of leukopenia? The patient usually does not notice the signs of leukopenia ... Leukopenia treatment. The treatment of leukopenia primarily depends on the one that causing it. For an instance, if it is a ... What is Leukopenia?. Leukopenia definition. White blood cells are the army of the body. They are medically called leukocytes. ... Leukopenia causes. There are a number of health conditions that cause leukopenia. These include the following:. *Suppression or ...
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The Experimental Production of Splenomegaly, Anemia and Leukopenia in Albino Rats | Blood | American Society of Hematology
The Experimental Production of Splenomegaly, Anemia and Leukopenia in Albino Rats J. G. PALMER, M.D., J. G. PALMER, M.D. * ... leukopenia, a mild thrombocytopenia in 9 of the 10 animals, ascites, and infiltration of the spleen, liver and kidneys with " ... Anemia and Leukopenia in Albino Rats. Blood 1953; 8 (1): 72-80. doi: https://doi.org/10.1182/blood.V8.1.72.72 ...
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Gengraf Oral Solution (Cyclosporine Oral Solution): Uses, Dosage, Side Effects, Interactions, Warning
Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Neulasta® - Full Text View - ClinicalTrials.gov
This randomized, double-blind trial compared the proposed biosimilar LA-EP2006 with the reference Neulasta® in women (≥18 years) receiving chemotherapy for breast cancer. Therefore patients were randomized to receive LA-EP2006 (n = 159) or the reference product (n = 157) for ≤6 cycles of (neo)-adjuvant TAC (docetaxel 75mg/m^2, doxorubicin 50 mg/m^2, and cyclophosphamide 500mg/m^2) chemotherapy. The primary end point was the duration of severe neutropenia (DSN) during Cycle 1 (defined as number of consecutive days with absolute neutrophil count ,0.5 × 10^9/l). The equivalence was confirmed if 95% CIs were within a ±1 day margin. LA-EP2006 was equivalent to the reference product in DSN (difference: 0.07 days; 95% CI [-0.12, 0.26]). Further, LA-EP2006 and the reference Neulasta® showed no clinically meaningful differences regarding efficacy and safety ...
ThrombocytopeniaNeutropeniaLeukocytosisAnemiaBone marrowWBCsSplenomegalyClinicalSymptomsDiseasesImmune systemMedicationsDiseasePatientsBloodTreatmentCondition is calledHealthNormalPatientLymphopeniaCause leukopeniaInfectionsChemotherapyDecreaseDisordersLymphocytopeniaFelineDescriptorPatientsMildDiagnosisInfectionPeripheralPreventionBoneAnorexiaLupusAIDSMalnutritionLaboratoryCommon
Thrombocytopenia6
- The intraperitoneal administration of methyl cellulose into rats over a period of fifteen weeks resulted in the development of a syndrome characterized by massive splenomegaly, hyperplasia of the bone marrow elements, normocytic, normochromic anemia, reticulocytosis, leukopenia, a mild thrombocytopenia in 9 of the 10 animals, ascites, and infiltration of the spleen, liver and kidneys with "storage-cell" macrophages. (ashpublications.org)
- Leucopenia and thrombocytopenia have been observed with treatment with ORFADIN. (prnewswire.com)
- Leukopenia, thrombocytopenia, and episodic crises are common. (ispub.com)
- However, borderline leukopenia (4.45 x 10 9 /L), borderline thrombocytopenia (167 x 10 9 /L), an elevated serum CK level (238 U/L), hyponatremia (128.2 mmol/L), and a progressively elevated serum LDH level (1,138 U/L) were noted. (cdc.gov)
- The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. (cdc.gov)
- This leucovorin "rescue" prevents or reduces the toxicity of methotrexate, which is expressed as mouth lesions (stomatitis), injury to the gastrointestinal epithelium (diarrhea), leukopenia, and thrombocytopenia. (medicinalplants.us)
Neutropenia7
- Leukopenia is closely related to neutropenia. (medscape.com)
- Leukopenia, Neutropenia, and Agranulocytosis have been reported with antipsychotics. (nih.gov)
- Patients with a pre-existing low white blood cell count (WBC) or a history of leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and SAPHRIS should be discontinued at the first sign of a decline in WBC in the absence of other causative factors. (nih.gov)
- There are various forms of leukopenia but the most common form is neutropenia. (healthool.com)
- The doctor will order for CBC (complete blood count) to check the components of the blood and confirm the diagnosis of leukopenia and neutropenia. (healthool.com)
- Life-threatening events included dizziness, leukopenia, and neutropenia. (medpagetoday.com)
- Blood dyscrasias such as agranulocytosis, leukopenia and neutropenia are possible with thioridazine treatment. (mental-health-matters.org)
Leukocytosis2
- Some patients have leukopenia early and leukocytosis after the first week. (haz-map.com)
- An increase in the number of leukocytes over the upper limits is called leukocytosis, and in leukopenia, this number is much lower than the lower limit. (techxplore.com)
Anemia1
- If left unmanaged could lead to anemia and leukopenia. (healthool.com)
Bone marrow1
- Cancer that metastasize to the bone marrow - Any types of cancer that metastasize to the bone marrow could lead to leukopenia. (healthool.com)
WBCs1
- A low number of WBCs is called leukopenia. (ucsfhealth.org)
Splenomegaly1
- Leukopenia - Increased destruction or sequestration of leukocytes causes the leukopenia observed in splenomegaly. (medscape.com)
Clinical1
- Ganoderma has been used for the clinical treatment of chronic bronchitis, bronchial asthma, leukopenia, coronary heart disease, arrhythmia, and acute infectious hepatitis. (kolhapur-mushrooms.in)
Symptoms1
- What are the signs and symptoms of leukopenia? (healthool.com)
Diseases1
- Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. (alpineacupuncture.com)
Immune system1
- One is leukopenia, or loss of white blood cells, a constraint for this type of chemotherapy because it impairs the immune system. (eurekalert.org)
Medications2
- Other leukopenia medications include antibiotics and antifungals to treat bacterial and fungal infections. (healthool.com)
- Approximately 10% of pregnant women taking thioamide medications have transient leukopenia, which does not require discontinuation. (exxcellence.org)
Disease2
- There are many causes Leukopenia Disease but let us first know what leucopenia is? (leukopeniadisease.com)
- this may be a new therapy target for Graves' disease with leukopenia. (uwi.edu)
Patients2
- Leukopenia was detected in only four (17%) patients. (cdc.gov)
- Contexte: Pour contrôler la propagation de la maladie à coronavirus 19 (COVID-19) causée par le syndrome respiratoire aigu sévère coronavirus-2 (SRAS-CoV-2), il est nécessaire d'identifier et d'isoler de manière adéquate les patients infectieux, en particulier sur le lieu de travail. (bvsalud.org)
Blood2
- Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. (alpineacupuncture.com)
- If the number of white blood cells goes below the normal level, the condition is called leukopenia. (healthool.com)
Treatment1
- The treatment of leukopenia primarily depends on the one that causing it. (healthool.com)
Condition is called1
- The condition is called as leukopenia. (healthguidance.org)
Health3
- Leukopenia can be caused through use of some drugs or through other health problems. (leukopeniadisease.com)
- There are a number of health conditions that cause leukopenia. (healthool.com)
- Other health conditions - What is a condition that can cause leukopenia? (healthool.com)
Normal1
- Disminución del número de LEUCOCITOS en una muestra de sangre, por debajo del rango normal (RECUENTO DE LEUCOCITOS inferior a 4.000). (bvsalud.org)
Patient1
- If the leukopenia is caused by a genetic condition, then the patient should be put on a granulocyte colony-stimulating factor. (healthool.com)
Lymphopenia1
- Comparison of children hospitalized with enterovirus or human parechovirus (HPeV) detected in their cerebrospinal fluid revealed that HPeV infections presented with more persistent fever, irritability and feeding problems, more frequent leukopenia and lymphopenia and higher admission rates to high dependency or intensive care units. (nih.gov)
Cause leukopenia4
- There are various medications which can cause leukopenia and also by some antibiotics, barbiturates, diuretics and other drugs. (leukopeniadisease.com)
- Also, cancer treatments can cause leukopenia, such as bone marrow transplant, radiation therapy (especially when it is used on large bones, such as those in your pelvis and legs) and chemotherapy. (homenaturalcures.com)
- Every single person that has a condition which can cause leukopenia has a risk of getting it. (homenaturalcures.com)
- How do autoimmune diseases cause leukopenia? (healthtap.com)
Infections6
- Leukopenia is a common finding in systemic lupus erythematosus (SLE) and may contribute to severe infections. (medscape.com)
- The objectives of this study were to determine the prevalence of leukopenia in SLE patients and examine the association between these conditions and severe infections noting the risk factor of severe infections. (medscape.com)
- As white blood cells (WBCs) have a major role in the immune system in preventing infection, leukopenia may contribute to severe infections in SLE. (medscape.com)
- So leukopenia treatment becomes important here because if the immune system of the body gets weakened then the affected person may not be able to fight even the minor infections. (leukopeniadisease.com)
- So in this condition leukopenia treatment is performed by delaying the ongoing treatments in case of rise of infections. (leukopeniadisease.com)
- These infections can affect the bone marrow or there can be other severe infections which can lead to leukopenia. (homenaturalcures.com)
Chemotherapy2
- for preventing leukopenia caused by chemotherapy in lung cancer patients, a randomized trial was carried out. (nih.gov)
- Mistletoe extract reduces leukopenia in chemotherapy-treated mice and stimulates neutropoiesis in mice after cyclophosphamide chemotherapy [ 25 ]. (hindawi.com)
Decrease2
- Leukopenia is the decrease in number of white blood cells in the human blood. (leukopeniadisease.com)
- An abnormal decrease in number is known as leukopenia. (physio-pedia.com)
Disorders2
- Autoimmune disorders can kill white blood cells or bone marrow cells, which make the blood cells, can also lead to leukopenia. (homenaturalcures.com)
- Some of the autoimmune disorders which could lead to leukopenia include rheumatoid arthritis and lupus . (homenaturalcures.com)
Lymphocytopenia1
- Lymphocytopenia is another common type of leukopenia. (homenaturalcures.com)
Feline1
- Her feline leukopenia booster was 750 pesos. (bradleyfarless.com)
Descriptor1
- Leukopenia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Patients7
- There was no difference of severe infection-free survival rate between patients who ever and never had leukopenia. (medscape.com)
- Various immunotherapeutic modalities have been used based on the autoimmune pathogenic mechanisms of myasthenia gravis (MG). Cell-mediated immunity as well as auto-antibodies may play a role in the remission and relapse of MG. We recently experienced two patients with MG who showed spontaneous remission fter inadvertent severe leukopenia. (e-acn.org)
- Herein we describe two case reports of ADPKD patients with leukopenia. (giornaleitalianodinefrologia.it)
- However, the clinical significance of leukopenia in ADPKD patients is not known. (giornaleitalianodinefrologia.it)
- It could be interesting to investigate the leucocytes' function and if ADPKD patients with leukopenia are more susceptible to infection, or not. (giornaleitalianodinefrologia.it)
- Acute leukopenia occurs in all patients during the first hour of hemodialysis with cellophanemembrane equipment. (semanticscholar.org)
- Contexte: Pour contrôler la propagation de la maladie à coronavirus 19 (COVID-19) causée par le syndrome respiratoire aigu sévère coronavirus-2 (SRAS-CoV-2), il est nécessaire d'identifier et d'isoler de manière adéquate les patients infectieux, en particulier sur le lieu de travail. (bvsalud.org)
Mild1
- West Nile encephalitis (WNE), as with many viral illnesses, may feature mild leukopenia. (medscape.com)
Diagnosis2
- Leukopenia was found at the diagnosis in 51.6% of the cases. (medscape.com)
- Leukopenia may suggest the diagnosis. (medscape.com)
Infection4
- In this study, the presence of leukopenia at any time was not the risk factor for severe infection in SLE. (medscape.com)
- The association between leukopenia and severe infection remains controversial in SLE. (medscape.com)
- The association between leukopenia and infection is a time-dependent relationship. (medscape.com)
- Leukopenia is a condition where a person has a reduced number of white blood cells and an increased risk of infection. (medicalnewstoday.com)
Peripheral1
- Antioxidant mechanism of diallyl sulfide in inhibiting leucopenia in peripheral blood induced by benzene. (greenmedinfo.com)
Prevention1
- The basic leukopenia treatment and its prevention are to have a healthy and balanced diet which can ensure necessary vitamins and minerals in it. (leukopeniadisease.com)
Bone2
- [ 4 ] Leukopenia in SLE may result from SLE disease activity or bone marrow suppression from immunosuppressant(s), comedications, or other medical conditions. (medscape.com)
- When these granulomas are forming in your bone marrow, then the leukopenia can happen. (homenaturalcures.com)
Anorexia2
- A blood test on a 14-year-old girl, who suffers from anorexia nervosa, revealed not only a leukopenia but a lymphocytosis. (medscape.com)
- Leukopenia and Anorexia Nervosa - Medscape - Feb 18, 2003. (medscape.com)
Lupus3
- [ 1 , 2 ] Leukopenia is common in SLE and is included in both the American College of Rheumatology (ACR) [ 3 ] and the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria of SLE. (medscape.com)
- It is mostly detected in people who are already getting a medical treatment or those who are being tested for leucopenia, AIDS, lupus or other. (leukopeniadisease.com)
- Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. (goldenmonkeyhealing.com)
AIDS1
- Some infectious diseases, like tuberculosis and HIV or AIDS, can lead to leukopenia. (homenaturalcures.com)
Malnutrition1
- Many a times the reason behind the causing of leukopenia is something greater than malnutrition. (leukopeniadisease.com)
Laboratory1
- Her initial laboratory testing revealed nonspecific elevation in several inflammatory markers and leukopenia, and she responded well to intravenous hydration. (aap.org)
Common3
- Leukopenia was common in SLE but usually not persistent. (medscape.com)
- Some of the most common vitamin and mineral deficiencies which lead to leukopenia include zinc, copper, folate and Vitamin B12. (homenaturalcures.com)
- Leukopenia is common with propranolol ingestion. (aaan.org)