LeukopeniaDrug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Hematologic Diseases: Disorders of the blood and blood forming tissues.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Lung Neoplasms: Tumors or cancer of the LUNG.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Cellophane: A generic name for film produced from wood pulp by the viscose process. It is a thin, transparent sheeting of regenerated cellulose, moisture-proof and sometimes dyed, and used chiefly as food wrapping or as bags for dialysis. (Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Gastric Fistula: Abnormal passage communicating with the STOMACH.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Carboplatin: An organoplatinum compound that possesses antineoplastic activity.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Bone Marrow DiseasesAnemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Phlebovirus: A genus of the family BUNYAVIRIDAE comprising many viruses, most of which are transmitted by Phlebotomus flies and cause PHLEBOTOMUS FEVER. The type species is RIFT VALLEY FEVER VIRUS.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Menogaril: A semisynthetic anthracycline with the amino sugar on the D ring. It displays broad-spectrum antineoplastic activity against a variety of tumors.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Ehrlichia: Small, often pleomorphic, coccoid to ellipsoidal organisms occurring intracytoplasmically in circulating LYMPHOCYTES. They are the etiologic agents of tick-borne diseases of humans; DOGS; CATTLE; SHEEP; GOATS; and HORSES.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.DeoxycytidineCamptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Aminopterin: A folic acid derivative used as a rodenticide that has been shown to be teratogenic.Ehrlichiosis: A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Mycophenolic Acid: An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Nogalamycin: An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.Alopecia: Absence of hair from areas where it is normally present.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Platelet Count: The number of PLATELETS per unit volume in a sample of venous BLOOD.Bunyaviridae Infections: Virus diseases caused by the BUNYAVIRIDAE.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Rickettsiaceae Infections: Infections with bacteria of the family RICKETTSIACEAE.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Maximum Tolerated Dose: The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Erythrocyte Count: The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.Ifosfamide: Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Pneumonia, Staphylococcal: Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).Time Factors: Elements of limited time intervals, contributing to particular results or situations.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.Mechlorethamine: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Tegafur: Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Infusions, Parenteral: The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.6-Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Breast Neoplasms: Tumors or cancer of the human BREAST.Ehrlichia chaffeensis: A species of gram-negative bacteria that is the causative agent of human EHRLICHIOSIS. This organism was first discovered at Fort Chaffee, Arkansas, when blood samples from suspected human ehrlichiosis patients were studied.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Epothilones: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.Interferon-alpha: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.Recurrence: The return of a sign, symptom, or disease after a remission.Platinum: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".Endotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Increase of hematopoietic responses by triple or single helical conformer of an antitumor (1-->3)-beta-D-glucan preparation, Sonifilan, in cyclophosphamide-induced leukopenic mice. (1/834)
It has been suggested that the immunopharmacological activity of soluble (1-->3)-beta-D-glucan depends on its conformation in mice. In this study, we examined the relationship between the conformation of Sonifilan (SPG) and hematopietic responses in cyclophosphamide (Cy)-induced leukopenic mice. SPG, a high molecular weight (1-->3)-beta-D-glucan, has a triple helical conformation in water, and it was changed by treatment with aqueous sodium hydroxide to the single helical conformer (SPG-OH). The effects of SPG or SPG-OH on hematopoietic responses in cyclophosphamide induced leukopenic mice were investigated by monitoring i) gene expression of cytokines by RT-PCR, ii) protein synthesis of interleukin 6 (IL-6) by ELISA and iii) colony formation of bone marrow cells (BMC). The mice administered Cy and SPG or SPG-OH expressed and produced higher levels of IL-6 mRNA and protein than the mice administered only Cy. Gene expression of NK1.1 was also induced by Cy/SPG (or SPG-OH) treatment. Induced gene expression of stem cell factor (SCF) and macrophage-colony stimulating factor (M-CSF) by SPG/SPG-OH were also found in in vitro culture of BMC from Cy treated mice. These results strongly suggested that conformation of the glucans, single and triple helix, are independent of the hematopietic response. (+info)A phase I/II study of continuous intra-arterial chemotherapy using an implantable reservoir for the treatment of liver metastases from breast cancer: a Japan Clinical Oncology Group (JCOG) study 9113. JCOG Breast Cancer Study Group. (2/834)
BACKGROUND: Liver metastasis from breast cancer has a poor prognosis. While there are some reports of good response rates of hepatic metastasis from breast cancer by hepatic intra-arterial infusion chemotherapy, no phase I study including pharmacokinetic analysis has been reported. We performed a phase I/II study of intra-arterial infusion chemotherapy using adriamycin and 5-fluorouracil to find the maximum tolerated dose and response rate in patients with advanced or recurrent breast cancer. METHODS: A hepatic arterial catheter with an access port was inserted into the proper hepatic artery. Patients received 30 mg/m2 adriamycin on days 1 and 8 and 100 mg/m2 5-fluorouracil at level 1, 200 mg/m2 at level 2,300 mg/m2 at level 3 and 400 mg/m2 at level 4 continuously from day 1 through day 14 every 28 days. At least two cycles were required before evaluation. Twenty-eight patients were entered into this study and 26 patients were evaluable. Seventeen patients had hepatic metastasis only, although nine patients had additional metastasis to other sites. RESULTS: Dose-limiting toxicity of thrombocytopenia and neurotoxicity occurred at level 4. Leukocytopenia (ECOG grade 3-4) was observed in five (19%), thrombocytopenia in three (12%) and anemia in two (8%) patients. There were 11 catheter-related complications which were not dose dependent. Seven out of 13 evaluable patients (54%) responded at level 3. The median duration of response was 5.8 months (range, 1-23+) and median survival was 25.3 months (range, 6.2-54.7+). CONCLUSION: Hepatic arterial infusion therapy appears to be safe and effective but catheter-related complications must be overcome before starting a phase III trial. (+info)Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide. (3/834)
Rats pretreated with traces of LPS developed acute fatal shock syndrome after i.v. administration of a mAb that inhibits the function of a membrane complement regulatory molecule. Such a shock was not observed after the administration of large amounts of LPS instead of the mAb following LPS pretreatment. The lethal response did not occur in rats depleted of either leukocytes or complement, and a C5a receptor antagonist was found to inhibit the reaction. Furthermore, LPS-treated rats did not suffer fatal shock following the injection of cobra venom factor, which activates complement in the fluid phase so extensively as to exhaust complement capacity. Therefore, complement activation on cell membranes is a requirement for this type of acute reaction. (+info)Quantitative and qualitative effects of cyclophosphamide administration on circulating polymorphonuclear leucocytes. (4/834)
The effect of cyclophosphamide (CY) on the absolute numbers and function of polymorphonuclear leucocytes (PMN) surviving in the circulation following either a single dose (100 mg/kg, i.p.) or daily administration (20 mg/kg, i.p., for 5 days) was studied in the guinea-pig. The quantitative effect of CY on peripheral blood leucocytes was assessed by measuring the absolute numbers of neutrophils, lymphocytes, and monocytes daily for 5 days following the initial injection of CY. The qualitative effects of CY on PMN function were determined by measuring the ability of these cells to function as killer cells. The two functional assays employed were the PMN-mediated PHA-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) assays against chicken erythrocyte targets. Both regimens of CY administration produced an equivalent degree of leukopenia 5 days after the initial injection with disproportionately severe neutropenia (less than 300 PMN/mm3). However, neither regimen of CY administration produced a significant decrease in cytotoxic effector function as measured through a wide range of effector to target cell ratios, PHA concentrations, and antiserum dilutions. These findings have clinical relevance in that they demonstrate the dichotomy between the quantitative and qualitative effects of (CY) on PMNs in that CY administration can dramatically decrease the absolute numbers of circulating polymorphonuclear leucocytes while leaving intact certain effector cell functional capabilities of those PMN surviving in the circulation during drug administration. (+info)Lithium dosage and leukocyte counts in psychiatric patients. (5/834)
OBJECTIVE: To evaluate differences in leukocyte counts among patients treated with either lithium alone, antipsychotic medications alone, or a combination of both. DESIGN: Retrospective study. SETTING: Long-stay psychiatric hospital. PATIENTS: Patients admitted between 1990 and 1993, and treated with lithium for at least 1 week and/or with antipsychotic medication for at least 2 weeks. Excluded from the study were those patients for whom complete blood counts at baseline and during therapy were not available, and those patients whose blood picture could primarily be accounted for by extraneous factors. Included in the study were 38 patients treated with lithium alone, 207 patients receiving antipsychotic medications alone, and 71 patients receiving both. OUTCOME MEASURES: Leukocyte, lymphocyte and granulocyte counts. RESULTS: Patients treated with lithium alone had significantly higher mean leukocyte and granulocyte counts than those treated with antipsychotic medication alone (analysis of variance, p < 0.05). None of the patients receiving lithium alone showed leukopenia. The dosage of lithium was significantly correlated with leukocyte count (r = 0.25, 95% confidence interval [CI] 0.14 to 0.35, p < 0.001,) and granulocyte count (r = 0.27, 95% CI 0.16 to 0.38, p < 0.001), but not with lymphocyte count (r = 0.06, p = 0.286, 95% CI -0.05 to 0.17). CONCLUSIONS: Lithium therapy is associated with higher leukocyte and granulocyte levels in psychiatric patients. This leukocytotic effect of lithium may be dose dependent. (+info)Phase I study of a biweekly schedule of a fixed dose of cisplatin with increasing doses of paclitaxel in patients with advanced oesophageal cancer. (6/834)
We performed this dose-finding study with a fixed dose of cisplatin and increasing doses of paclitaxel given every 2 weeks to determine the maximum tolerable dose of this schedule. Sixty-four patients with advanced oesophageal cancer were treated with a cisplatin dose of 60 mg m(-2) and increasing doses of paclitaxel from 100 mg m(-2) up to 200 mg m(-2) both administered over 3 h for a maximum of six cycles in patients with stable disease or eight cycles in responding patients. Patients were retreated when the granulocytes were > 0.75 x 10(9) l(-1) and the platelets > 75 x 10(9) l(-1). The dose of paclitaxel could be increased to 200 mg m(-2) without encountering dose limiting haematological toxicity. At the dose levels 190 mg m(-2) and 200 mg m(-2) of paclitaxel cumulative sensory neurotoxicity became the dose-limiting toxicity. The dose intensity of paclitaxel calculated over six cycles rose from 50 mg m(-2) per week to 85 mg m(-2) per week. Only three episodes of granulocytopenic fever were encountered out of a total of 362 cycles of treatment. Of the 59 patients evaluable for response, 31 (52%) had a partial or complete response. In a biweekly schedule with a fixed dose of 60 mg m(-2) cisplatin it is possible to increase the dose of paclitaxel to 180 mg m(-2). At higher dose levels, neurotoxicity becomes the dose-limiting toxicity. The observed response rate warrants further investigation of this schedule. (+info)Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. (7/834)
The histological identification of increased eosinophils in the gastrointestinal tract occurs in numerous clinical disorders; however, there is a limited understanding of the mechanisms regulating eosinophil trafficking into this mucosal surface. The results presented in this study characterize the processes regulating eosinophil homing into the gastrointestinal tract at baseline. Eosinophils were found to be present in the lamina propria of 19-day-old embryos and germ-free adult mice at concentrations comparable to those present in non-germ-free adult mice. Furthermore, eosinophil gastrointestinal levels were not altered by increasing circulating eosinophils after pulmonary allergen challenge. Gastrointestinal eosinophil levels were partially reduced in mice deficient in recombinase activating gene-1 (RAG-1), IL-5, or the beta common chain (betac), but these reductions paralleled reductions in circulating eosinophils. In contrast, mice deficient in eotaxin had a marked reduction in gastrointestinal eosinophils but normal levels of eosinophils in the hematopoietic compartments. Furthermore, eotaxin was important for regulating eosinophil levels, even in the presence of high levels of IL-5. These investigations demonstrate eosinophil homing into the gastrointestinal tract during embryonic development occurring independently of viable intestinal flora. Furthermore, eotaxin is identified as the primary regulator of eosinophil gastrointestinal homing under homeostatic states, and may therefore have a fundamental role in innate immune responses. (+info)Prevention of febrile leucopenia after chemotherapy in high-risk breast cancer patients: no significant difference between granulocyte-colony stimulating growth factor or ciprofloxacin plus amphotericin B. (8/834)
In a prospective randomized trial, 40 stage IV breast cancer patients undergoing intermediate high-dose chemotherapy (cyclophosphamide, 5-fluorouracil plus epirubicin or methotrexate), received either recombinant human G-CSF (rhG-CSF, group I) or ciprofloxacin and amphotericin B (CAB, group II) for prevention of febrile leucopenia (FL). In group I, seven of 18 patients developed FL (after 10/108 courses); in group II, seven of 22 patients (7/98 courses) (P = NS). Median hospitalization duration and costs were not different. RhG-CSF was 6.6 times more expensive per course than CAB. In conclusion, prophylactic CAB has similar efficacy to rhG-CSF in this setting, and is more cost-effective. (+info)
The response of peripheral lymphocytes of nude mice and leucopenic hyb by L Korcakova and M Holub
Infection from Finger Sticks in Leukopenic Patients | Annals of Internal Medicine | American College of Physicians
Monocytopenia | Article about monocytopenia by The Free Dictionary
Items | Valcyte
White Blood Cells | Leukopenia Disease
Myelofibrosis | Leukopenia Disease
Could having leukopenia lead to hodgkin disease or any other type of cancers? - Answered by top doctors on HealthTap
leukopenia Archives - Acupuncture in Portland, OR
Leukopenia: causes, treatment and types of diseases - Health Tips
Docetaxel - SNPedia
Word Information - search results for: leucopenic
Pandemic (H1N1) 2009 and HIV Co-infection - Volume 16, Number 10-October 2010 - Emerging Infectious Disease journal - CDC
What conditions can lead to leukopenia? | Reference.com
What Is Leukopenia and How Can It Be Diagnosed and Treated?
Millirad to Leukopenia
Leukopenia | GreenMedInfo | Disease | Natural Medicine | Alternative
Leukopenia - WikiMD
Untitled
Simple model for the study of Pseudomonas aeruginosa infections in leukopenic mice. | Infection and Immunity
Leukopenia - Wikipedia
CHAPTER 77 MONOCYTOSIS AND MONOCYTOPENIA | Free Medical Textbook
Understanding Leukopenia (Low White Blood Cell Count)
Thrombocytopenia Leukopenia
Leukopenia: Causes, Symptoms & Treatment | artplay-katok.ru
October 2017 - Urban Acupuncture
Buy Chinese herb remedies for Leucopenia Anemia
Hong Kongs pricey housing - CBC Player
Plus it
ICD 9 Code for Chronic Leukopenia | Medical Billing and Coding Online
Clinical Trial | Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia,...
Bone Marrow Suppression During and After Chemotherapy
Bone Marrow Suppression During Cancer Treatment in Children
Bone Marrow Suppression During Cancer Treatment in Children
201 Procalcitonin and eosinopenia as potential biomarkers of infection in critically ill patients with systemic lupus...
Drug-induced leukopenia
Notes from Dr. RW: Eosinopenia as a predictor of sepsis
How to Increase White Blood Cell Count - Health Hearty
Bone marrow suppression - Wikipedia
leukopenia | Articles related to leukopenia | Open Access Journal | Annex Publishers
Leucopenia - Illinois CancerCare
Untitled Document
Leukocytes Tutorial | Sophia Learning
White Blood Cell
Coggle
Odol-transfusio - Wikipedia, entziklopedia askea.
Imuran generic price - price online
Multiple Sclerosis Research: To deplete or not to deplete that is the question?
Five Ways to Increase White Blood Cell Count with TCM - CuredByNature.net
Neutropenia | WBCCount.org
Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry |...
Cancer - Classical Acupuncture Exeter and North Tawton
Low Monocyte Count | WBCCount.org
nausea and vomiting Hemic and lymphatic system: Leukopenia Immune system : Hypersensitivity reactions Nervous system: Amnesia -...
Anticipating Cytopenia: In Vitro Methods for Hematotoxicity Testing
Granulocytopenia synonyms, granulocytopenia antonyms - FreeThesaurus.com
Vinblastine injection - Cancer Therapy Advisor
Database for hematological malignancy
Korean Journal of Acupuncture
Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China
Morbid Streak: October 2015
Bioremediation of radioactive waste
Leukopenia. Growth reduction. Reproductive deficiencies: sterility, reduction in fecundity, and occurrence of developmental ...
Protriptyline
... leukopenia;thrombocytopenia; purpura; eosinophilia. Gastrointestinal: Nausea and vomiting; anorexia; epigastric distress; ...
Sicilian Virus
Marked leukopenia may occur. Patients may also experience transient diarrhea or constipation with abdominal discomfort. The ...
Brucella
Hematological signs include anemia, leukopenia, and thrombocytopenia. Brucella is isolated from a blood culture on Castaneda ...
Lamotrigine
... has been associated with a decrease in white blood cell count (leukopenia). Lamotrigine does not prolong QT/QTc in ... Nicholson, R J; Kelly, K P; Grant, I S (25 February 1995). "Leucopenia associated with lamotrigine". BMJ. Retrieved 16 June ...
Cytopenia
Low white blood cell count: leukopenia or neutropenia. Because neutrophils make up at least half of all white cells, they are ... almost always low in leukopenia[citation needed]. Low platelet count: thrombocytopenia. Low granulocyte count: granulocytopenia ...
Toxic megacolon
Severe sepsis may present with hypothermia or leukopenia. The objective of treatment is to decompress the bowel and to prevent ...
Management of Crohn's disease
The rare side effects include leukopenia or pancreatitis. There may also be an increased risk of lymphoma that is associated ...
Amoebic liver abscess
A transitory leucopenia may occur. Cardiovascular symptoms are rare. Treatment should be discontinued promptly if ataxia or any ...
Human monocytotropic ehrlichiosis
Laboratory abnormalities include thrombocytopenia, leukopenia, and elevated liver tests. The severity of the illness can range ...
White blood cell
A decrease below the lower limit is called leukopenia. This indicates a weakened immune system. The name "white blood cell" ... leukopenias). Leukocytosis is usually healthy (e.g., fighting an infection), but it also may be dysfunctionally proliferative. ...
PGM3 deficiency
Additionally, patients have significant leukopenia, lymphopenia, neutropenia, and eosinophilia. Mild defects in T-cell function ...
Cirrhosis
Leukopenia and neutropenia - due to splenomegaly with splenic margination. Coagulation defects - the liver produces most of the ...
Fumarase deficiency
Laboratory findings in neonates may indicate polycythemia, leukopenia, or neutropenia. As they age, neurological deficits begin ...
Batai virus
Symptoms are characterized by fever, vomiting, diarrhea, thrombocytopenia and leukopenia. SFTS virus has a 6-30% fatality rate ...
Psittacosis
Fatal cases have been reported (less than 1% of cases). Blood analysis shows leukopenia, thrombocytopenia and moderately ...
Palbociclib
Leukopenia and anemia are also frequent among patients taking palbociclib. More than 10% of patients also experience side ...
Lymphocytic choriomeningitis
In all reported cases, the initial symptoms included fever, lethargy, anorexia and leukopenia, and quickly progressed to ... Pathological findings during the first stage consist of leukopenia and thrombocytopenia. During the second phase, typical ...
Ehrlichiosis ewingii infection
Laboratory tests may reveal thrombocytopenia, leukopenia, and evidence of liver damage. Humans contract the disease after a ...
Gaucher's disease
Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia. The brain and nervous system are ... Hypersplenism and pancytopenia, the rapid and premature destruction of blood cells, leads to anemia, neutropenia, leukopenia, ...
Pyrimethamine
Hematologic side effects such as thrombocytopenia, leukopenia, and anemia can also occur. Other antifolate agents such as ...
NUDT15
Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. ... September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nature Genetics ... in acute lymphoblastic leukemia as well as inflammatory bowel diseases to avoid thiopurine-induced leukopenia. These variants ...
Gynostemma pentaphyllum
1992). "Therapeutic effect of jiaogulan on leukopenia due to irradiation and chemotherapy". Zhong Guo yi Yao Xue Bao. 7 (2): 99 ...
Monocytopenia
... is a form of leukopenia associated with a deficiency of monocytes. The causes of monocytopenia include: acute ...
Azathioprine
September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nature Genetics ... has been identified to be a causal factor for AZA-induced leukopenia through a genome wide association study (GWAS) in East ...
Intrauterine growth restriction
Hypothermia, thrombocytopenia, leukopenia, hypocalcemia, and pulmonary hemorrhage are often results of IUGR. If the cause of ...
Monocyte
Monocytopenia is a form of leukopenia associated with a deficiency of monocytes. A very low count of these cells is found after ...
Anaplasma phagocytophilum
The disease is multisystemic, but the most severe changes are anaemia and leukopenia. This organism causes lameness which can ... Other symptoms include fever, headache, absence of skin rash, leucopenia, thrombocytopenia and mild injury to the liver. ... especially if they experience leukopenia and/or thrombocytopenia. In animals, antibiotics such as oxytetracycline, ...
Coltivirus
Beclamide
Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated ...
What conditions can lead to leukopenia? | Reference.com
Leukopenia, or low white blood cell count, may be caused by diseases such as leukemia, AIDS, various types of liver disease, ... Leukopenia, or low white blood cell count, may be caused by diseases such as leukemia, AIDS, various types of liver disease, ...
Leukopenia | GreenMedInfo | Disease | Natural Medicine | Alternative
Diseases : Chemotherapy-Induced Toxicity, Gastric Cancer, Leukopenia, Leukopenia: Chemotherapy Induced. Additional Keywords : ... Camel milk may have an immunopotentiating role in diseases or conditions associated with leukopenia or drug-induced toxicities. ... Cats claw (Uncaria tomentosa) is a potential agent for clinically accelerating the recovery of patients from leukopenia.Jan 01 ... The protective effects of diallyl sulfide (DAS) on benzene-induced leukopenia.Apr 19, 2019. ...
What Is Leukopenia and How Can It Be Diagnosed and Treated?
Leukopenia is a deficiency in white blood cells. Learn what causes this condition and what complications can develop if it is ... Treatment of Leukopenia. Treating a low white blood cell count can be done in several ways. If it is possible to treat the ... Causes of Leukopenia. White blood cells are produced in the bone marrow, so any medical condition that disrupts or halts bone ... Leukopenia is the medical term for a low white blood cell count. White blood cells are essential for proper immune system ...
Could having leukopenia lead to hodgkin disease or any other type of cancers? - Answered by top doctors on HealthTap
Leukopenia is not. The cause of cancer, but it can be a sign that something is wrong in the body. For some, leukopenia is a ... Leukopenia means low white cell count. It can be associated with various things, which can include: infection (eg., cold/ flu, ... Some develop leukopenia because its a side effect of a medication that theyre taking. Others just have lower white blood cell ... Could having leukopenia lead to hodgkin disease or any other type of cancers? ...
Leukopenia - WikiMD
Help WikiMD:Join WikiMD as an an editor and help improve the page Leukopenia or others.. ... Link to this page: ,a href="http://www.wikimd.org/wiki/Leukopenia",Leukopenia,/a,. ... Retrieved from "http://www.wikimd.org/wiki/index.php?title=Leukopenia&oldid=83312" ...
Millirad to Leukopenia
unitsconverters.com helps in the conversion of different units of measurement like Millirad to Leukopenia through ... Leukopenias Conversion mrd stands for millirads and Leukopenia stands for leukopenias. The formula used in millirads to ... How to convert Millirad to Leukopenia?. The formula to convert Millirad to Leukopenia is 1 Millirad = 5E-06 Leukopenia. ... Leukopenia How to convert millirad to leukopenia? In the absorbed dose measurement, first choose millirad from the left ...
leukopenia Archives - Acupuncture in Portland, OR
Tag Archives: leukopenia. Five Ways to Increase White Blood Cell Count with TCM. By admin , Published October 2, 2017 ... Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. ... Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. This condition may make those ...
Leukopenia: causes, treatment and types of diseases - Health Tips
What is leukopenia in adults?. This particular pathological condition, which implies a low blood levels of white blood cells, ... How to treat leukopenia?In the case of a moderate variant of the disease are appointed by the following drugs: "leucogen", " ... Leukopenia - a pathological condition which is characterized by impaired blood formation at the level of white blood cells. ... is important to note that it will take a long time to finally overcome this malaise, leukopenia.The causes of the disease, as ...
Word Information - search results for: leucopenic
leukocytopenia, leukopenia, leukopenic, leucopenic. 1. An abnormal lowering of the white blood cell count.. 2. An excessive ...
Untitled
Leukopenia JAMA A decrease in the number of white blood cells. The threshold value for leukopenia is usually defined as fewer ...
Items | Valcyte
Hematologic Toxicity: Severe leukopenia, neutropenia, anemia, thrombocytopenia, pancytopenia, bone marrow failure, and aplastic ... In patients with severe leukopenia, neutropenia, anemia and/or thrombocytopenia, treatment with hematopoietic growth factors ... Hematologic toxicity: Severe leukopenia, neutropenia, anemia, thrombocytopenia, pancytopenia, bone marrow depression, and ...
Leukopenia (Leukocytopenia, Leucopenia)
... or leucopenia) is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at ... Management of leukopenia. Treatment of leukopenia depends on the cause of the condition. For example, if there is a bone marrow ... Leukopenia forms. The most common form of leukopenia is neutropenia. Normally Neutrophils comprise about 45 to 75 percent of ... Diagnosis of leukopenia and neutropenia. A complete blood count helps in diagnosis of leukopenia and neutropenia. Neutropenia ...
Leukopenia | Buzzle.com
Leukopenia. When one is hit down by leukopenia, the number of white blood cells in the body decreases drastically. When such a ... Leukopenia: Causes of Low White Blood Cells. Leukopenia is a condition characterized by decrease in the white blood cells or ... What is Leukopenia. Leukopenia refers to abnormal lowering in the white blood cell count of a person. This Buzzle article ... Symptoms and Treatment of Leukopenia. Leukopenia is a decrease in the number of white blood cells found in blood. It decreases ...
Leukopenia News, Research
Leukopenia News and Research. RSS Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, ...
What Causes Leukopenia? | Reference.com
Leukopenia is caused by a variety of medical issues including viral infections, autoimmune disorders, medications, aplastic ... What Conditions Can Lead to Leukopenia?. A: Leukopenia, or low white blood cell count, may be caused by diseases such as ... Leukopenia is a medical condition in which a patient has a low white blood cell count, reports Mayo Clinic. Typically, if a ... Leukopenia is caused by a variety of medical issues including viral infections, autoimmune disorders, medications, aplastic ...
Leukopenia - Wikipedia
Minocycline, a commonly prescribed antibiotic, is another drug known to cause leukopenia. There are also reports of leukopenia ... Leukopenia can be identified with a complete blood count. Below are blood reference ranges for various types leucocytes/WBCs. ... Leukopenia (from Greek λευκός (leukos), meaning white, and πενία (penia), meaning deficiency) is a decrease in the number ... The terms leukopenia and neutropenia may occasionally be used interchangeably, as the neutrophil count is the most important ...
Leukopenia - definition of leukopenia by The Free Dictionary
leukopenia synonyms, leukopenia pronunciation, leukopenia translation, English dictionary definition of leukopenia. also leu·co ... leukopenia - an abnormal lowering of the white blood cell count. leucopenia. blood disease, blood disorder - a disease or ... leukopenia. Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia. leu·ko·pe·ni·a. also leu·co·pe·ni·a (lo͞o′kə-pē′nē-ə). ... Leukopenia - definition of leukopenia by The Free Dictionary https://www.thefreedictionary.com/leukopenia ...
leukopenia | EUdict | English...
... leukopenia in English->English dictionary. Search nearly 13 million words and phrases in more than 460 language pairs. ... Results for: leukopenia. English. English. leukopenia. abnormal decrease in the number of white blood cells in the blood, ... leukopenia senatende motstå vétéran 鋪張 铺张 haro churrero silovati inauspiciously ingenium mala sæpe movent shinobinaku ...
Leukopenia - ONA
Most cases of leukopenia are associated with a low number of granulocytes. ... is informative in the diagnosis of certain leukopenias. ... Leukopenia. *Novel Agent Tolerable, Active for Advanced ...
Leukopenia - wikidoc
Basophilic leukopenia (aka basophilic leukocytopenia, basophilic leucopenia, basophilic leucocytopenia, basophilopenia) Reduced ... Neutrophilic leukopenia. (aka neutrophilic leukocytopenia, neutrophilic leucopenia, neutrophilic leucocytopenia, neutropenia) ... Eosinophilic leukopenia (aka eosinophilic leukocytopenia, eosinophilic leucopenia, eosinophilic leucocytopenia, ... neutrophilic leukopenia, neutrophilic leukocytopenia, neutrophilic leucopenia, neutrophilic leucocytopenia, neutropenia, ...
I've Leukopenia Help Doc. Please - Forum on Fatigue and Anemia - TheBody.com
Ive Leukopenia Help Doc. Please. Dec 13, 2001 ive been diagnosed that I have Leukopenia where WBS(3100) and anemia where ... Your laboratory studies show you have a low white blood cell count (leukopenia) and anemia - low red blood cell count or ... to try to determine the cause for your leukopenia and anemia. Its always best to treat the underlying cause of a problem, if ...
Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. - PubMed - NCBI
Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia.. Liu WC1, Chuang WL, Tsai ML, Hong JH, ... In summary, CS enhances recovery of mice from leukopenia caused by Taxol treatment. It appears to do so by protecting both ... Cordyceps sinensis Health Supplement Enhances Recovery from Taxol-Induced Leukopenia. Exp Biol Med (Maywood). ;233(4):447-455. ... Cordyceps sinensis Health Supplement Enhances Recovery from Taxol-Induced Leukopenia. Exp Biol Med (Maywood). ;233(4):447-455. ...
Leucopenia | GreenMedInfo | Disease | Natural Medicine | Alternative
Diseases : Benzene Toxicity, Leucopenia, Oxidative Stress. Pharmacological Actions : Antioxidants, Malondialdehyde Down- ... Antioxidant mechanism of diallyl sulfide in inhibiting leucopenia in peripheral blood induced by benzene.Oct 19, 2019. ...
leucopenia - definition and meaning
leukopenia. .. from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.. *noun an abnormal lowering of the ... As his leucopenia improved, we re-started the drug which reversed the rejection process and his renal function improved. ... Feied invented this word as well, stealing the suffix from "leucopenia," or low white-blood-cell counts.) ... I was told that I also had leucopenia, a dangerously low white blood cell count. ...
Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia
Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia. Maja ... "Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia," Case ...
Syndrome of Cocaine-Levamisole-Induced Cutaneous Vasculitis and Immune-Mediated Leukopenia.
... leukopenia, and antineutrophil cytoplasmic antigen (ANCA) positivity most likely as a result of a hypersensitivity reaction to ... CONCLUSIONS: Cocaine-levamisole-related cutaneous vasculitis with leukopenia is a diagnosis of exclusion, but this diagnosis ... OBJECTIVE: We describe 4 patients who presented with palpable purpura, arthralgia or arthritis, leukopenia, and antineutrophil ... leukopenia, and positive ANCA in high titers and negative Antimyeloperoxidase, when other infectious or idiopathic vasculitic ...
Leukopenia with MEPROBAMATE
LEUKOPENIA Causes, Patient Concerns and Latest Treatments and MEPROBAMATE Reports and Side Effects. ... Can the drug cause leukopenia? Sincerely yours. I have had a speckled ana, leukopenia but no symptoms of anything except ... Check out the latest treatments for LEUKOPENIA. ➢ LEUKOPENIA treatment research studies. ➢ MEPROBAMATE clinical trials, surveys ... LEUKOPENIA Symptoms and Causes. We are sorry, but no medical information on this topic currently exists in our database. Our ...
Drug-induced leukopenia
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share ... Among the drugs that can cause leukopenia are antithyroid drugs, chemotherapy agents, antimetabolites, phenothiazines, ...
Decreased protein binding of mycophenolic acid associated with leukopenia in a pancreas transplant recipient with renal failure...
Decreased protein binding of mycophenolic acid associated with leukopenia in a pancreas transplant recipient with renal failure ...
leukopenia | Taber's Medical Dictionary
leukopenia answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android ... leukopenia is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please log in or purchase a ... "Leukopenia." Tabers Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Tabers Online, www.tabers.com/tabersonline/view/ ... Tabers-Dictionary/731847/all/leukopenia. Leukopenia. In: Venes DD, ed. Tabers Medical Dictionary. F.A. Davis Company; 2021. ...
Natural Remedies for Leukopenia
Reishi in particular was shown to be useful as a natural remedy for Leukopenia in clinical studies ... Pollen and Reishi Mushroom would be useful for Leukopenia. ... Leukopenia can be caused by a number of drugs or other health ... Supplements for Leukopenia. The supplements recommended for the treatment of Leukopenia are listed below. Not all will ... You are here: Library Health Conditions Leukopenia Get a FREE Health Guide. ...plus all the latest news and offers. Just enter ...
Solian Leukopenia Side Effects
View Leukopenia Solian side effect risks. Female, 29 years of age, was diagnosed with schizophrenia, paranoid type and took ... Is Leukopenia a common side effect of Solian? ... Home → Solian → Leukopenia The following Solian Leukopenia side ... Grand Mal Convulsion, Long Qt Syndrome, Bradycardia, Leukopenia This Leukopenia side effect was reported by a physician from ... Solian Leukopenia Causes and Reviews We are sorry, but no medical information on this topic currently exists in our database. ...
Leukopenia and thrombocytopenia due to fusidic acid. | Postgraduate Medical Journal
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
ATROPHIC ARTHRITIS ASSOCIATED WITH SPLENOMEGALY AND LEUKOPENIA* | Annals of Internal Medicine | American College of Physicians
In 1924 Felty1 reported the cases of five adults who had atrophic arthritis associated with splenomegaly and leukopenia. The ... ATROPHIC ARTHRITIS ASSOCIATED WITH SPLENOMEGALY AND LEUKOPENIA* FRANCIS N. HATCH, M.D. ... ATROPHIC ARTHRITIS ASSOCIATED WITH SPLENOMEGALY AND LEUKOPENIA*. Ann Intern Med. 1945;23:201-220. doi: https://doi.org/10.7326/ ...
Articles On Leukopenia|OMICS International|Journal Of Blood Disorders And Transfusion
Leukopenia is an abnormal diminishment of circulating white blood cells, especially the granulocytes. White blood cells are the ... Articles On Leukopenia. Leukopenia is an abnormal diminishment of circulating white blood cells, especially the granulocytes. ... The term leukopenia is often used interchangeably with neutropenia. Neutropenia is mostly responsible because of medications, ...
The American Journal of Tropical Medicine and Hygiene | Leukopenia Associated with Mebendazole Therapy of Hydatid Disease
Abstract The occurrence of transient leukopenia with relative neutropenia in a patient treated with a short course of high-dose ... Leukopenia Associated with Mebendazole Therapy of Hydatid Disease * Paul F. Miskovitz, Norman B. Javitt ... The occurrence of transient leukopenia with relative neutropenia in a patient treated with a short course of high-dose ...
Swiss Medical Weekly - Leucopenia associated with metamizole: a case-control study
... but can be associated with leucopenia. If risk factors for this complication were known, these could be used to identify ... were screened for metamizole-associated leucopenia. Cases of leucopenia (leucocyte count below 3.5 × 109/l) occurring during ... The definition of leucopenia, a leucocyte count below 3.5 × 109/l, was in accordance with the local population reference range ... Characteristics of the leucopenia Figure 1 shows the leucocyte and neutrophil values for the case and control subgroups; all ...
J Clin Psychiatry/Venlafaxine in a Patient With Idiopathic Leukopenia and Mirtazapine-Induced Severe Neutropenia
Here, we present a patient with a known idiopathic leukopenia and cross-intolerance between tricyclic antidepressants and ... Venlafaxine in a Patient With Idiopathic Leukopenia and Mirtazapine-Induced Severe Neutropenia ...
NeutropeniaChemotherapy-induced leukopeniaDiseasesDiallyl sulfideWhite bloodTreatmentPatients2017ChemotherapyCauses of LeukopeniaAbnormally lowLeukocytopeniaLeukocytesDisease2019DiseasesAnemiaNeutrophilsSymptoms of leukopeniaAbnormalForm of leukopeniaKnown as leukopeniaCases of leukopeniaLeukocytosis and LeukopeniaChronic leukopeniaToxicityLeukocyte countInfectionsDiagnosisWhiteClinicalInfectionTreatmentsNounOccurWBCsPrednisoneEnhancesIdiopathicValproic acid
Neutropenia1
- In patients with severe leukopenia, neutropenia, anemia and/or thrombocytopenia, treatment with hematopoietic growth factors and or the interruption of therapy is recommended. (genentechmaterials.com)
Chemotherapy-induced leukopenia1
- Acupuncture has therapeutic value in treating chemotherapy-induced leukopenia. (greenmedinfo.com)
Diseases2
- Camel milk may have an immunopotentiating role in diseases or conditions associated with leukopenia or drug-induced toxicities. (greenmedinfo.com)
- Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. (east-westacupuncture.com)
Diallyl sulfide1
- The protective effects of diallyl sulfide (DAS) on benzene-induced leukopenia. (greenmedinfo.com)
White blood1
- Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. (east-westacupuncture.com)
Treatment1
- Astragalus may be an effective treatment against leukopenia. (greenmedinfo.com)
Patients1
- Cats claw (Uncaria tomentosa) is a potential agent for clinically accelerating the recovery of patients from leukopenia. (greenmedinfo.com)
20171
- 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623589/all/LEUKOPENIA. (unboundmedicine.com)
Chemotherapy13
- Acupuncture has therapeutic value in treating chemotherapy-induced leukopenia. (greenmedinfo.com)
- Chemotherapy and radiation treatments are also capable of causing leukopenia because they are used to kill fast-growing cells and leukocytes can get caught in the way. (doctorshealthpress.com)
- The treatment is known to cause severe hematological toxicity such as leukopenia, which can lead to chemotherapy cessation or even death. (aacrjournals.org)
- In this study we aim to identify genetic markers for chemotherapy induced leukopenia in non-small cell lung cancer. (aacrjournals.org)
- Besides funds for chemotherapy, adverse reactions in the form of leukopenia has a large number of different groups of drugs (neuroleptics, hormones), so the dosage form of leukopenia over half of the population suffers elderly.For women is more common occurrence of this disease than men. (diets-doctor.com)
- Cats claw ameliorates chemotherapy-induced leukopenia in a rat model. (greenmedinfo.com)
- Pretreatment with Neem diminishes leukopenia and enhances the effect of chemotherapy. (greenmedinfo.com)
- An interesting new study has found that the inclusion of green jackfruit flour as a dietary intervention prevents chemotherapy-induced leukopenia in patients undergoing chemotherapy along with Pegfilgrastim (Pegylated filgrastim). (asianmeditour.com)
- Clinical study with Jackfruit365™ Flour at Renai Medicity Hospital has demonstrated prevention of leukopenia and common side effects of chemotherapy, according to Dr Thomas Varughese, Oncologist & Surgeon, HOD, Cancer Division, Renai Medicity Hospital. (asianmeditour.com)
- It was found that none of them had leukopenia in any of the six cycles of chemotherapy. (asianmeditour.com)
- The impact of these results on the global scenario will be recruitment of more patients, who due to toxicity, fail to complete ideal treatments as well as those who refuse chemotherapy due to the fear of developing leukopenia. (asianmeditour.com)
- According to him, complete avoidance of leukopenia, greatly enhances the quality of life of treating doctors and staff as well, since they need not waste precious hours for treating complications of chemotherapy. (asianmeditour.com)
- Different terms such as Leukopenia, Leukopenia (decreased white blood cells in blood), Leukopenia not chemotherapy or radiation related or Leukopenia, not chemotherapy or radiation can be used to describe such condition. (medicalbillingcodings.org)
Causes of Leukopenia1
- Common causes of leukopenia are viral infections that disrupt bone marrow function, certain prescription drugs that destroy white blood cells, cancers, and autoimmune disorders. (healthresearchfunding.org)
Abnormally low2
- Leukopenia is a condition where a person has an abnormally low white blood cell count and has a direct affect on the body's immune system. (healthresearchfunding.org)
- Leukopenia is an abnormally low number of white blood cells, or leukocytes. (rush.edu)
Leukocytopenia1
- Leukopenia - (or leukocytopenia, or leucopenia, from Greek λευκό white and πενία deficiency) is a decrease in the number of circulating white blood cells (leukocytes) in the blood. (enacademic.com)
Leukocytes15
- Leukopenia (from Greek λευκός (leukos), meaning 'white', and πενία (penia), meaning 'deficiency') is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection. (wikipedia.org)
- Leukopenia is a condition characterized by decrease in the white blood cells or the leukocytes in the blood. (buzzle.com)
- The 9 China cases differed from the 44 US cases in that the patients from China were significantly less likely to report headache but significantly more likely to have diarrhea, leukopenia , severe leukopenia ([less than or equal to] 3,000 leukocytes/[mm. (thefreedictionary.com)
- The majority of cases of leukopenia are actually neutropenia since neutrophils constitute the majority of leukocytes. (wikidoc.org)
- Leukocytes are a type of white blood cell, and when the body has low levels of them, leucopenia is the result. (doctorshealthpress.com)
- Consequently, conditions that can cause leukopenia are ones that either kill leukocytes faster than they can be produced or which interfere with the bone marrow in some way. (doctorshealthpress.com)
- Leukopenia indicates that a proliferation of myeloma cells may be inhibiting the production of a normal level of leukocytes. (cancerforums.net)
- There are three main etiopathogenetic mechanism of leukopenia: violation of the production of white blood cells in the blood, circulating leukocytes failure or redistribution, as well as accelerate the destruction of neutrophils. (diets-doctor.com)
- With a significant decrease in leukocytes in the blood, they talk about leukopenia. (arrhythmia.center)
- Leukopenia is a decrease in the number of leukocytes in the blood, which is most often a symptomatic condition and accompanies various diseases. (arrhythmia.center)
- The term "leukopenia" is a general term referring to a reduced number of leukocytes in peripheral blood. (arrhythmia.center)
- Since monocytes, eosinophils, and basophils make up a relatively small proportion of the total pool of circulating leukocytes, leukopenia is almost always caused by neutropenia or lymphopenia. (arrhythmia.center)
- Persistent leukopenia, according to doctors, leading to decreased immunity and a simultaneous increase in sensitivity to many infections and cancer illnesses, which often entails death.The extreme manifestations of the disease are the following: agranulocytosis, neutropenia and aleukia.In this case, the body is almost completely ceases to produce certain types of leukocytes. (healthtipsing.com)
- A person effected with a leucopenia have a tremendous decrease in the number of total white blood cells (leukocytes) found in blood. (medicalbillingcodings.org)
- Leucopenia is a decrease in the number of white blood cells (leukocytes) circulating in the blood. (medwonders.com)
Disease11
- Leukopenia, or low white blood cell count, may be caused by diseases such as leukemia, AIDS, various types of liver disease, aplastic anemia and rheumatoid. (reference.com)
- As a child, I had watched my father suffer through a constellation of what I have since learned were autoimmune illnesses: inflammatory bowel disease, rheumatoid arthritis, and leucopenia . (wordnik.com)
- The occurrence of transient leukopenia with relative neutropenia in a patient treated with a short course of high-dose mebendazole therapy for inoperable hydatid disease is reported. (ajtmh.org)
- S. aureus- necrotizing pneumonia is still an extremely severe disease in patients with severe leukopenia. (biomedcentral.com)
- Characterization of these serum inhibitory factors may facilitate understanding of leukopenia in human disease. (symptoma.com)
- I have a past history of collagen vascular disease and leukopenia. (healthcaremagic.com)
- Leukopenia, which develops over a period of weeks or months, may be associated with chronic infection or a primary disease of the bone marrow. (arrhythmia.center)
- Any disease or condition that disrupts the production or function of bone marrow will cause the body to establish leukopenia. (artplay-katok.ru)
- Leukopenia - a pathological condition which is characterized by impaired blood formation at the level of white blood cells.Unfortunately, in recent years the prevalence of the disease is increasing.Why is this? (healthtipsing.com)
- Treatment of the disease is impossible as long as the doctor will not know exactly what the main reason, which caused leukopenia.Otherwise, it will be assigned to the wrong treatment, and the disease continues to progress. (healthtipsing.com)
- dysplastic and neoplastic lesions of the bone marrow itself, which also cause leukopenia disease (leukemia, metastatic lesions, and so on. (healthtipsing.com)
20191
- Retrieved on December 13, 2019 from https://www.news-medical.net/health/What-is-Leukopenia.aspx. (news-medical.net)
Diseases9
- Leukopenia may be caused by diseases, medications, and genetic deficiencies. (news-medical.net)
- Leukopenia, i.e., abnormal decline in white blood cells (WBCs) in the body, can weaken your immune system, and make you vulnerable to a range of infectious diseases. (buzzle.com)
- Camel milk may have an immunopotentiating role in diseases or conditions associated with leukopenia or drug-induced toxicities. (greenmedinfo.com)
- Background: More than 20% of inflammatory bowel diseases (IBD) patients discontinue thiopurine therapy due to severe adverse drug reactions among which leucopenia is one of the most serious. (uu.nl)
- Leukopenia is often seen in diseases such as AIDS, cancer and lupus, as well as in common occurrences like the flu or a cold. (east-westacupuncture.com)
- The diseases that most often provoke the development of leukopenia are hypersplenism, chronic idiopathic neutropenia in adults, rheumatoid arthritis, systemic lupus erythematosus, Wegener's granulomatosis. (arrhythmia.center)
- Your doctor will carry out assessments to figure out which of these diseases is the most likely cause of your leukopenia. (artplay-katok.ru)
- Lymphogranulomatosis, neutropenia, leukopenia, monocytosis - all fairly common diseases binds only one - the pathological changes at the level of white blood cells.In this article, we will consider only one option from the list. (healthtipsing.com)
- Leucopenia can put you at increased risk of infections and diseases. (medwonders.com)
Anemia6
- ive been diagnosed that I have Leukopenia where WBS(3100) and anemia where hemoglobin 11000. (thebody.com)
- Your laboratory studies show you have a low white blood cell count (leukopenia) and anemia - low red blood cell count or hemoglobin. (thebody.com)
- But first, you should see your physician or a blood doctor specialist (hematologist) to try to determine the cause for your leukopenia and anemia. (thebody.com)
- A low red blood cell count (anemia) can often occur alongside leukopenia as the body begins to lose red blood cells without enough white blood cells to protect them. (doctorshealthpress.com)
- Leukopenia is a shortage of white blood cells in the system, which can be caused by anemia, menorrhagia, etc. (artplay-katok.ru)
- Leucopenia Anemia. (globalchineseherbhealing.com)
Neutrophils1
- Medications that can cause leukopenia include clozapine, an antipsychotic medication with a rare adverse effect leading to the total absence of all granulocytes (neutrophils, basophils, eosinophils). (wikipedia.org)
Symptoms of leukopenia1
- It is important to recognize the symptoms of leukopenia in time, which are often vague, which allows for proper treatment. (arrhythmia.center)
Abnormal2
- Leukopenia refers to abnormal lowering in the white blood cell count of a person. (buzzle.com)
- Leukopenia is an abnormal diminishment of circulating white blood cells, especially the granulocytes. (omicsonline.org)
Form of leukopenia1
- The most common form of leukopenia is neutropenia. (news-medical.net)
Known as leukopenia2
- A clinical condition, known as leukopenia occasionally occurs in which the bone marrow produces very few white blood cells, leaving the body unprotected against many bacteria and other agents that might invade the tissues. (ukessays.com)
- Having a low number of these cells, are known as Leukopenia . (healthrenewal.co.za)
Cases of leukopenia1
- Most cases of leukopenia are associated with a low number of granulocytes. (oncologynurseadvisor.com)
Leukocytosis and Leukopenia1
- The lecture Leukocytosis and Leukopenia - White Blood Cell Pathology by Carlo Raj, MD is from the course Quantitative White Blood Cell Disorders - White Blood Cell Pathology (WBC). (lecturio.com)
Chronic leukopenia1
- A recurrent problematic illness that results in a low white blood cell (WBC) count is known as chronic leukopenia. (buzzle.com)
Toxicity1
- Chronic administration of certain groups of drugs, leukopenia is due to toxicity, immune and allergic effects on the body as a whole and in the central organs of hematopoiesis in particular. (diets-doctor.com)
Leukocyte count1
- The definition of "leukopenia" varies, but in most laboratories the lower limit of the normal total leukocyte count is from 3000 / μl to 4000 / μl. (arrhythmia.center)
Infections3
- Leukopenia caused due to bacterial or fungal infections may be treated with appropriate antibiotics and antifungals respectively. (news-medical.net)
- Regular or unusual infections, particularly constant GINGIVITIS or periodontitis, might be there as Leukopenia symptoms . (leukopeniadisease.com)
- Leukopenia, which develops acutely, is often caused by drugs with the development of agranulocytosis, acute infections or acute leukemia. (arrhythmia.center)
Diagnosis3
- A complete blood count helps in diagnosis of leukopenia and neutropenia. (news-medical.net)
- Peripheral blood smear and bone marrow aspirate, with or without bone marrow biopsy, is informative in the diagnosis of certain leukopenias. (oncologynurseadvisor.com)
- ncreasing the temperature, dizziness - all symptoms that suggest a diagnosis of leukopenia.Causes of such clinical signs for a long time can not be known.The final diagnosis can only confirm the analysis of the blood. (healthtipsing.com)
White18
- In leukopenia there is a diminished white blood cell count. (news-medical.net)
- When one is hit down by leukopenia, the number of white blood cells in the body decreases drastically. (buzzle.com)
- Leukopenia is a medical condition in which a patient has a low white blood cell count, reports Mayo Clinic. (reference.com)
- Typically, if a patient has less than 4,000 white blood cells per microliter of blood, then he is diagnosed with leukopenia. (reference.com)
- His complete blood count (CBC) was significant for a leukopenia to 2,700 white blood cells (WBCs) per [mm. (thefreedictionary.com)
- Leukopenia is the medical term for a low white blood cell count. (brighthub.com)
- If it is possible to treat the underlying cause of the leukopenia, white blood cell levels can be restored and low white blood counts can be prevented. (brighthub.com)
- Feied invented this word as well, stealing the suffix from " leucopenia ," or low white-blood-cell counts. (wordnik.com)
- I was told that I also had leucopenia , a dangerously low white blood cell count. (wordnik.com)
- Leukopenia (low white blood cell count) is not so much a condition as it is a state of the body. (doctorshealthpress.com)
- Viruses can cause leukopenia by both slowing the function of bone marrow and by killing off white blood cells. (doctorshealthpress.com)
- Treatment-induced leukopenia (reduced number of white blood cells) is one condition for which acupuncture treatment has been suggested. (cam-cancer.org)
- If the thing is left untreated, then other leukopenia symptoms might occur like pneumonia and other different blood disorders because of low count of white blood cells. (leukopeniadisease.com)
- Leukopenia means the "white reduction" and it is a term used to refer to the low white blood cells count. (wbccount.org)
- Leukopenia is a term used when there are less than adequate white blood cells in the bloodstream. (east-westacupuncture.com)
- A low white blood cell count, or leukopenia will have a direct impact on your body's body immune system. (artplay-katok.ru)
- Thus, one should distinguish between increased white blood cell count and low.It was the latter is called leukopenia. (healthtipsing.com)
- If the total white cell count drops below 3,500 per cubic millimeter in the blood , the person is said to be suffering from leucopenia. (medicalbillingcodings.org)
Clinical1
- Reishi in particular was shown to be useful as a natural remedy for Leukopenia in clinical studies (Tamura et al.1987). (regenerativenutrition.com)
Infection3
- The terms leukopenia and neutropenia may occasionally be used interchangeably, as the neutrophil count is the most important indicator of infection risk. (wikipedia.org)
- CONCLUSIONS: A history of allergies, previous leucopenic episodes, hepatitis C infection and concomitant cytostatic agents are possible risk factors for leucopenia associated with metamizole use. (smw.ch)
- It can usually be killed with medication, provided it is prednisone leukopenia taken shortly after the infection occured. (blisswithguy.com)
Treatments1
- Read on what are the symptoms of and treatments for leukopenia. (buzzle.com)
Noun1
- noun Alternative spelling of leukopenia . (wordnik.com)
Occur3
- When we discontinued the drug because of leucopenia , rejection started to occur. (wordnik.com)
- This information will help you understand how side effects, such as Leukopenia, can occur, and what you can do about them. (patientsville.com)
- This type of leucopenia symptoms occur when less number of blood platelets is there in the body. (leukopeniadisease.com)
WBCs1
- Those with genetic conditions leading to leukopenia may need granulocyte colony-stimulating factor and other bone marrow-derived growth factors to stimulate production of the WBCs. (news-medical.net)
Prednisone7
- Furthermore, what is prednisone leukopenia seen on a background check more preferably than city of fort lauderdale arrest search. (blisswithguy.com)
- You prednisone leukopenia can find all of these supplements fairly cheap if you know where to shop. (blisswithguy.com)
- I ve prednisone leukopenia spent some time looking for such tips. (blisswithguy.com)
- From a practical standpoint, there prednisone leukopenia are many ways to approach this issue. (myfitnesstipster.com)
- My mother really likes carrying out investigation and it is easy prednisone leukopenia to see why. (myfitnesstipster.com)
- Whats up, yeah prednisone leukopenia this article is actually pleasant and i have learned lot of things from it about blogging. (myfitnesstipster.com)
- Been on androgel for about 10 years now prednisone leukopenia with all of the benefits. (myfitnesstipster.com)
Enhances1
- Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. (nih.gov)
Idiopathic1
- Here, we present a patient with a known idiopathic leukopenia and cross-intolerance between tricyclic antidepressants and mirtazapine who developed agranulocytosis with mirtazapine. (psychiatrist.com)
Valproic acid1
- There are also reports of leukopenia caused by divalproex sodium or valproic acid (Depakote), a drug used for epilepsy (seizures), mania (with bipolar disorder) and migraine. (wikipedia.org)
%2c_analyze_by_microscope-Jarun_Ontakrai_8864dd9cfb3b4dff9a913aede7a7c915-620x480.jpg)
