Leukemia, Biphenotypic, Acute
Immunophenotyping
Leukemia
Leukemia, Myeloid, Acute
Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. (1/35)
We have already reported that the quinol formation from some para-alkylphenols, which is a novel metabolic pathway catalyzed by cytochrome P-450, occurs in a rat liver microsomal system (). In the present study, we investigated whether estrone and 17beta-estadiol, each of which contains a p-alkylphenol moiety, are also oxidized into the corresponding quinols by cytochrome P-450. Six recombinant human cytochrome P-450 enzymes, CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2E1, and CYP3A4, were tested. The results show that estrone and 17beta-estadiol were converted into the corresponding quinols by CYP1A1, CYP2B6, and CYP2E1. (+info)The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. (2/35)
Polycomb group (PcG) proteins assemble to form large multiprotein complexes involved in gene silencing. Evidence suggests that PcG complexes are heterogeneous with respect to both protein composition and specific function. MPc3 is a recently described mouse Polycomb (Pc) protein that shares structural homology with at least two other Pc proteins, M33 and MPc2. All three Pc proteins bind another PcG protein, RING1, through a conserved carboxy-terminal C-box motif. Here, data are presented demonstrating that MPc3 also interacts with AF9, a transcriptional activator implicated in the development of acute leukemias. The carboxy-terminus of AF9 is fused to the MLL protein in leukemias characterized by t(9;11)(p22;q23) chromosomal translocations. Importantly, it is the carboxy-terminus of AF9 to which MPc3 binds. The AF9 binding site of MPc3 maps to a central, non-conserved, region of the polypeptide sequence. In contrast to MPc3, data indicate that the Pc protein M33 does not interact with AF9. This finding suggests a potentially unique role for MPc3 in linking a PcG silencing complex to a transcriptional activator protein. (+info)The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. (3/35)
We previously demonstrated that the 11q23 breakpoint region, designated the RCK locus, of the RC-K8 B-lymphoma cell line with t(11;14)(q23;q32) is centromeric to PBGD, while breakpoints of infantile leukemia cell lines with t(11;19)(q23;p13) are detectable by pulsed-field gel electrophoresis with the CD3D probe. In the present study, using a probe within 1.0 kilobase of the t(11;14) breakpoint, we isolated a partial complementary DNA clone for the putative RCK gene, which detects a 7.5-kilobase mRNA. Sequence analysis predicted a novel protein of 472 amino acids which demonstrated sequence homology to a translation initiation factor/helicase family. We also isolated a phage clone from the CD3D/G yeast artificial chromosome clone (yB22B2) which detects 11- and 12-kilobase mRNAs, most likely for the MLL/ALL-1 gene associated t(4;11)(q21;q23) and t(11;19)(q23;p13) translocations. By pulsed-field gel electrophoresis after NotI digestion, this recombinant clone is on a 96-kilobase fragment, while RCK and PBGD probes are on a more telomeric 690-kilobase NotI fragment. These results, altogether, suggested that two different genes, RCK and MLL/ALL-1, are associated with 11q23 translocation of hematopoietic tumors. (+info)Mixed lineage leukemia translocations and a leukemia stem cell program. (4/35)
Cancer stem cells (CSC) may provide the self-renewal capacity required to sustain a tumor. One possibility is that CSC arise from the stem cell counterparts in normal tissues. Alternatively, CSC may arise from more differentiated progenitor cells found in certain tissues. In support of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert committed hematopoietic progenitors into leukemias, which include leukemia stem cells expressing a self-renewal associated program in the context of a differentiated myeloid cell. The findings suggest a basis to understand the pathobiology of CSC and possible strategies to attack them to undermine the self-renewal capacity of a tumor. (+info)Relationship between in vitro chemosensitivity assessed with MTT assay and clinical outcomes in 103 patients with acute leukemia. (5/35)
BACKGROUND: Cellular drug resistance is supposed to play a major role in chemotherapy failure or relapse. The purpose of this study was to analyze the relationship between in vitro chemosensitivity test results using a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and clinical response on chemotherapy, and to find the possibility of optimizing the treatment protocol for individual patients according to their actual drug resistance. METHODS: For MTT assay, we obtained bone marrow aspirates from 103 patients with acute leukemia at the time of initial diagnosis or relapse. The following drugs were tested: cytarabine, vincristine, methotrexate, daunorubicin, dexamethasone, L-asparaginase, and mitoxantrone. To evaluate clinical responses after induction chemotherapy, we followed up on their bone marrow study. RESULTS: In our study, in vitro chemosensitivity test with the MTT assay significantly predicted whether patients with AML remained continuous complete remission or went into relapse. It also predicted whether or not child patients with ALL would acquire complete remission after induction chemotherapy. CONCLUSIONS: Although it does not provide the insight into the mechanisms that cause drug resistance, the MTT assay may be a useful tool in individually optimizing the chemotherapy of patients with acute leukemia. (+info)Potential use of the Macrobrachium rosenbergii lectin for diagnosis of T-cell acute lymphoblastic leukemia. (6/35)
T-cell acute lymphoblastic leukemia is the most common form of cancer in children. Lectins are proteins or glycoproteins from plants or animals that recognize oligossacharides on the cell surface and have been used to characterize the structural changes of oligosaccharides in leukemias. In this study, we used the lectin from the freshwater prawn Macrobrachium (M. rosenbergii), specific for acetyl groups in sialylated glycans, because increased sialylation of glycoproteins and glycolipids has been identified in lymphoblastic leukemias. We compared the specificity of the M. rosenbergii lectin for lymphoblastic leukemias with the specificities of the lectins from Triticum vulgaris, Solanum tuberosum, Arachis hipogaea, and Phytolacca americana. By morphologic and phenotype characterization with a panel of monoclonal antibodies, we identified four types of leukemias from 106 leukemia patients: 11 cases of T-cell acute lymphoblastic leukemia, 61 cases of B-cell acute lymphoblastic leukemia, 24 cases of acute myeloblastic leukemia, and 10 cases of acute biphenotypic leukemia. As determined by cytofluorometric assays, nine of the eleven cases with T-cell acute lymphoblastic leukemia (8 +/- 3 years old) were specifically identified with the lectin from M. rosenbergii. In contrast, only six cases of B-cell leukemia, one case of myeloblastic leukemia, and 2 cases of biphenotypic leukemia were identified with this M. rosenbergii lectin. The other lectins tested showed no capacity to differentiate, in a significant manner, any of the four types of leukemias tested. Thus, the lectin from M. rosenbergii could be considered a useful tool for the diagnosis and study of T-cell acute lymphoblastic leukemia. (+info)Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse. (7/35)
To define the clinical and biologic significance of childhood acute mixed-lineage leukemia diagnosed by stringent criteria, we studied 25 cases of acute lymphoblastic leukemia expressing greater than or equal to 2 myeloid-associated antigens (My+ ALL), and 16 cases of acute myeloid leukemia expressing greater than or equal to 2 lymphoid associated antigens (Ly+ AML). These cases represented 6.1% of 410 newly diagnosed ALLs (two treatment protocols) and 16.8% of 95 AMLs (two protocols). T-lineage--associated antigens were identified in 9 of the My+ ALL cases and in 14 of those classified as Ly+ AML; all but 1 of the 19 cases that could be subclassified had an early thymocyte stage of differentiation. The My+ ALL cases had an increased frequency of French-American-British (FAB) L2 morphology (36%); the Ly+ AML cases were characterized by FAB M1 or M2 morphology, low levels of myeloperoxidase reactivity and combined populations of myeloperoxidase-positive large blasts and small blasts generally of hand-mirror morphology. Karyotypic abnormalities included t(9;22)(q34;q11) in three cases of My+ ALL, 11q23 translocations in two cases of My+ ALL, and 14q32 translocations in three My+ ALL and five Ly+ AML cases. Mixed-lineage expression lacked prognostic significance in either ALL or AML; however, the findings indicate that some patients with Ly+ AML may respond to prednisone, vincristine, and L-asparaginase after failing on protocols for myeloid leukemia. At relapse, two My+ ALLs had converted to AML and two Ly+ AMLs to ALL; one case in each group showed complete replacement of the original karyotype. Acute mixed-lineage leukemia does not adequately describe the heterogeneity of the cases identified in this study and should be replaced by a set of more restrictive terms that indicate the unique biologic features of these leukemias. (+info)Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective. (8/35)
Menin is a tumor suppressor encoded by the MEN1 gene that is mutated in patients with an inherited syndrome, multiple endocrine neoplasia type 1 (MEN1). Loss of menin has potent impact on proliferation of endocrine and non-endocrine cells. However, until recently little has been known as to how menin regulates cell proliferation. Rapid research progress in the past several years suggests that menin represses proliferation of endocrine cells yet promotes proliferation in certain types of leukemia cells via interacting with various transcriptional regulators. Menin interacts with histone H3 methyltransferases such as MLL (mixed lineage leukemia) protein. Increasing evidence has linked the biological function of menin to epigenetic histone modifications, control of the pattern of gene expression, and regulation of cell proliferation in a cell type-specific manner. In light of these recent findings, an emerging model suggests that menin is a crucial regulator of histone modifiers by acting as a scaffold protein to coordinate gene transcription and cell proliferation in a cell context-dependent manner. This recent progress unravels the coordinating role of menin in epigenetics and regulation of cell cycle, providing novel insights into understanding regulation of beta cell functions and diabetes, as well as the development and therapy of endocrine tumors and leukemia. (+info)Biphenotypic acute leukemia (BAL) is a rare subtype of acute leukemia that possesses the features of both myeloid and lymphoid lineages. It is characterized by the presence of blasts that express antigens associated with both cell lines, which can make it challenging to diagnose and treat. BAL is considered an aggressive form of leukemia and requires prompt medical attention and treatment. The exact cause of BAL is not well understood, but like other forms of leukemia, it is thought to result from genetic mutations that lead to uncontrolled cell growth and division.
Immunophenotyping is a medical laboratory technique used to identify and classify cells, usually in the context of hematologic (blood) disorders and malignancies (cancers), based on their surface or intracellular expression of various proteins and antigens. This technique utilizes specific antibodies tagged with fluorochromes, which bind to the target antigens on the cell surface or within the cells. The labeled cells are then analyzed using flow cytometry, allowing for the detection and quantification of multiple antigenic markers simultaneously.
Immunophenotyping helps in understanding the distribution of different cell types, their subsets, and activation status, which can be crucial in diagnosing various hematological disorders, immunodeficiencies, and distinguishing between different types of leukemias, lymphomas, and other malignancies. Additionally, it can also be used to monitor the progression of diseases, evaluate the effectiveness of treatments, and detect minimal residual disease (MRD) during follow-up care.
Leukemia is a type of cancer that originates from the bone marrow - the soft, inner part of certain bones where new blood cells are made. It is characterized by an abnormal production of white blood cells, known as leukocytes or blasts. These abnormal cells accumulate in the bone marrow and interfere with the production of normal blood cells, leading to a decrease in red blood cells (anemia), platelets (thrombocytopenia), and healthy white blood cells (leukopenia).
There are several types of leukemia, classified based on the specific type of white blood cell affected and the speed at which the disease progresses:
1. Acute Leukemias - These types of leukemia progress rapidly, with symptoms developing over a few weeks or months. They involve the rapid growth and accumulation of immature, nonfunctional white blood cells (blasts) in the bone marrow and peripheral blood. The two main categories are:
- Acute Lymphoblastic Leukemia (ALL) - Originates from lymphoid progenitor cells, primarily affecting children but can also occur in adults.
- Acute Myeloid Leukemia (AML) - Develops from myeloid progenitor cells and is more common in older adults.
2. Chronic Leukemias - These types of leukemia progress slowly, with symptoms developing over a period of months to years. They involve the production of relatively mature, but still abnormal, white blood cells that can accumulate in large numbers in the bone marrow and peripheral blood. The two main categories are:
- Chronic Lymphocytic Leukemia (CLL) - Affects B-lymphocytes and is more common in older adults.
- Chronic Myeloid Leukemia (CML) - Originates from myeloid progenitor cells, characterized by the presence of a specific genetic abnormality called the Philadelphia chromosome. It can occur at any age but is more common in middle-aged and older adults.
Treatment options for leukemia depend on the type, stage, and individual patient factors. Treatments may include chemotherapy, targeted therapy, immunotherapy, stem cell transplantation, or a combination of these approaches.
Acute myeloid leukemia (AML) is a type of cancer that originates in the bone marrow, the soft inner part of certain bones where new blood cells are made. In AML, the immature cells, called blasts, in the bone marrow fail to mature into normal blood cells. Instead, these blasts accumulate and interfere with the production of normal blood cells, leading to a shortage of red blood cells (anemia), platelets (thrombocytopenia), and normal white blood cells (leukopenia).
AML is called "acute" because it can progress quickly and become severe within days or weeks without treatment. It is a type of myeloid leukemia, which means that it affects the myeloid cells in the bone marrow. Myeloid cells are a type of white blood cell that includes monocytes and granulocytes, which help fight infection and defend the body against foreign invaders.
In AML, the blasts can build up in the bone marrow and spread to other parts of the body, including the blood, lymph nodes, liver, spleen, and brain. This can cause a variety of symptoms, such as fatigue, fever, frequent infections, easy bruising or bleeding, and weight loss.
AML is typically treated with a combination of chemotherapy, radiation therapy, and/or stem cell transplantation. The specific treatment plan will depend on several factors, including the patient's age, overall health, and the type and stage of the leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma (previously known as Precursor T-lymphoblastic Leukemia/Lymphoma) is a type of cancer that affects the early stages of T-cell development. It is a subtype of acute lymphoblastic leukemia (ALL), which is characterized by the overproduction of immature white blood cells called lymphoblasts in the bone marrow, blood, and other organs.
In Precursor Cell Lymphoblastic Leukemia-Lymphoma, these abnormal lymphoblasts accumulate primarily in the lymphoid tissues such as the thymus and lymph nodes, leading to the enlargement of these organs. This subtype is more aggressive than other forms of ALL and has a higher risk of spreading to the central nervous system (CNS).
The medical definition of Precursor Cell Lymphoblastic Leukemia-Lymphoma includes:
1. A malignant neoplasm of immature T-cell precursors, also known as lymphoblasts.
2. Characterized by the proliferation and accumulation of these abnormal cells in the bone marrow, blood, and lymphoid tissues such as the thymus and lymph nodes.
3. Often associated with chromosomal abnormalities, genetic mutations, or aberrant gene expression that contribute to its aggressive behavior and poor prognosis.
4. Typically presents with symptoms related to bone marrow failure (anemia, neutropenia, thrombocytopenia), lymphadenopathy (swollen lymph nodes), hepatosplenomegaly (enlarged liver and spleen), and potential CNS involvement.
5. Diagnosed through a combination of clinical evaluation, imaging studies, and laboratory tests, including bone marrow aspiration and biopsy, immunophenotyping, cytogenetic analysis, and molecular genetic testing.
6. Treated with intensive multi-agent chemotherapy regimens, often combined with radiation therapy and/or stem cell transplantation to achieve remission and improve survival outcomes.
Biphenotypic acute leukaemia
International Classification of Diseases for Oncology
Acute myeloid leukemia
Mixed-phenotype acute leukemia
LL-100 panel
FLAG (chemotherapy)
List of cancer types
Leukemia
Chronic lymphocytic leukemia - Wikipedia
Pathology of Acute Leukemias of Ambiguous Lineage: Overview, Epidemiology, Clinical and Morphologic Features
Hairy Cell Leukemia-Variant: Causes, Diagnosis, and Treatment
Lauren Olander - Honored Kid | St. Baldrick's
Biphenotypic acute leukaemia - Wikipedia
Flow Cytometric Analysis of Acute Leukemias | Archives of Pathology & Laboratory Medicine
PE-Cy™5 Mouse Anti-Human CD19
t(3;11)(q21;q23) KMT2A/EEFSEC
925 Acute Lymphocytic Leukemia PPTs View free & download | PowerShow.com
Michael Cleary's Profile | Stanford Profiles
CLINICAL TRIAL / NCT04310592 - UChicago Medicine
Portal Regional da BVS
Worcester Cord Tissue Banking | New England Cord Blood Bank
Human KIR2DL1 / CD158a / NKAT-1 Protein, Fc Tag - ACROBiosystems
Value Set Concept Details
Diseases FDA-Approved for Cord Blood Treatments | Upstate Cord Blood Bank
Relapsed/Refractory AML Trial in Tianjin, Hangzhou (Uproleselan, Placebo) | Clincosm
Hematopoietic cell transplantation in adults with acute myeloid leukemia: A review of the results from various nationwide...
田中 美幸 | 信州大学研究者総覧
Immunophenotyping in Acute Leukemia - PT Master Guide
Búsqueda | BVS Bolivia
Benzamides | Colorado PROFILES
Paper: Breakthrough Invasive Fungal Infections (bIFI) Are Uncommon in Patients with Newly Diagnosed Acute Leukemia Receiving...
Acute Lymphoblastic Leukemia Differential Diagnoses
Efficacy of combination of venetoclax with azacitidine or chemotherapy in refractory/relapse acute leukemias of ambiguous...
MESH TREE NUMBER CHANGES - 2008 MeSH
MESH TREE NUMBER CHANGES - 2008 MeSH
MESH TREE NUMBER CHANGES - 2008 MeSH
MESH TREE NUMBER CHANGES - 2008 MeSH
Leukaemia9
- Biphenotypic acute leukaemia (BAL) is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability to differentiate into both myeloid and lymphoid lineages. (wikipedia.org)
- About 5% of acute leukaemia cases are BAL. (wikipedia.org)
- Acute biphenotypic leukaemia: immunophenotypic and cytogenetic analysis. (atlasgeneticsoncology.org)
- Intensification of treatment for adults with acute lymphoblastic leukaemia: results of U.K. Medical Research Council randomized trial UKALL XA. (medscape.com)
- One of the first cancers where major developments occurred for adolescents and young adults was acute lymphoblastic leukaemia. (leukaemia.org.au)
- Furthermore, I took part in the characterization of a mouse model with biphenotypic leukaemia and transdifferentiation mechanisms. (ox.ac.uk)
- Using retroviral expression screening for transforming genes in biphenotypic acute leukaemia, P2RY8 has been confirmed to have oncogenic potential (Fujiwara et al. (atlasgeneticsoncology.org)
- 50% of Down syndrome-associated acute lymphoblastic leukaemia (Mullighan et al. (atlasgeneticsoncology.org)
- As P2RY8-CRLF2 fusion in B-acute lymphoblastic leukaemia (B-ALL) and Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) (Mullighan et al. (atlasgeneticsoncology.org)
Myeloid leukemias2
- Leukemias affecting these cells are called myeloid leukemias. (healthline.com)
- This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Myeloblastic leukemia1
- Subtypes of AML include acute promyelocytic leukemia, acute myeloblastic leukemia, and acute megakaryoblastic leukemia. (rxharun.com)
Lineage9
- However, in a small subset of patients who present with acute leukemia, a specific lineage cannot be assigned. (medscape.com)
- These cases are characterized as acute leukemias of ambiguous lineage (ALAL). (medscape.com)
- and (2) those in which the malignant (blast) clone coexpresses lineage-specific markers (formerly known as biphenotypic acute leukemias). (medscape.com)
- If the score of only one lineage is higher than 2, the acute leukemia could be acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). (wikipedia.org)
- Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. (biomedcentral.com)
- Even more importantly, our work now for the first time, has allowed assessment of cell lineage on dictating aggression and leukemia stem cell frequency independent of the underlying oncogenic driver. (refine.bio)
- My research activity focuses on the role of haematopoietic lineage bias in the development of different types of acute leukaemias and how this contribution changes during ageing. (ox.ac.uk)
- Acute leukaemias arise through the sequential acquisition of mutations that lead to pre-leukaemic clonal expansion, followed by leukaemic transformation of lineage-restricted progenitors through their acquisition of ectopic self-renewal and impaired terminal differentiation. (ox.ac.uk)
- Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity. (ox.ac.uk)
Relapsed or refractory acute3
- This trial is studying a combination of drugs, venetoclax and navitoclax, to see how well they work in treating children with relapsed or refractory acute lymphoblastic leukemia or lymphoma. (withpower.com)
- Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. (drugbank.com)
- Gilteritinib is indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia with an FLT3 mutation detected by an FDA-approved test. (drugbank.com)
Lymphoid2
- Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
- There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
Chronic lymphocy3
- Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
- HCL-V affects B cells, so it's classified as a chronic lymphocytic leukemia (CLL). (healthline.com)
- Chronic lymphocytic leukemia (CLL) - most often affects adults over the age of 55. (rxharun.com)
Myelogenous Leukemia1
- Acute myelogenous leukemia (AML) - occurs more commonly in adults than in children, and more commonly in men than women. (rxharun.com)
Lymphocytic leukemias2
- In lymphoblastic or lymphocytic leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (rxharun.com)
- Most lymphocytic leukemias involve a specific subtype of lymphocyte, the B cell. (rxharun.com)
Subtype3
- It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
- As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
- One subtype is B-cell prolymphocytic leukemia, a more aggressive disease. (rxharun.com)
Megakaryoblastic leukemia1
- In approximately 50% of cases the type of leukemia is acute megakaryoblastic leukemia (AMKL) and it occurs during the first 4 years of life. (nih.gov)
Oncology3
- Acute Lymphocytic Leukemia Drug Pipeline Analysis and Therapeutic Assessment, H2 2016 - Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia Pipeline Review, H2 2016, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape. (powershow.com)
- Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia Pipeline Review, H2 2016, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape. (powershow.com)
- Guideline] NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia, Version 2:2015. (medscape.com)
20162
- The 2016 WHO update also emphasizes that for bilineal MPAL, it is more important that each individual blast population would meet the criteria for B, T, or myeloid leukemia, than that the specific markers below be present. (medscape.com)
- Global Acute Lymphocytic/Lymphoblastic Leukemia Therapeutics Market - The Global Acute Lymphocytic/Lymphoblastic Leukemia Therapeutics Market witnessed a rapid growth in the historic period from 2016 to 2019 and is anticipated to witness significant growth during the forecast period. (powershow.com)
Hematopoietic4
- Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
- Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
- Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
- Symptoms may vary from chronic symptoms like retinopathy, CKD, hematopoietic ulcers to severe acute complaints like "Sickle Cell Crisis" triggered by dehydration, infections, acidosis and other obscure reasons. (atomictherapy.org)
Morphology1
- If the patient has leukemia, the morphology and immunophenotype check is needed to make sure the type of leukemia. (wikipedia.org)
Phenotype2
- Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34;q11.2) (or BCR-ABL1 rearrangement) is also rare, accounting for less than 1% of acute leukemias. (medscape.com)
- in one case, the phenotype was described: it was a case of biphenotypic acute leukemia (BAL), a B-ALL expressing CD13 (Hanson et al. (atlasgeneticsoncology.org)
Include acute1
- Other conditions that should be considered in the evaluation of suspected acute ALL include acute biphenotypic leukemia and natural killer (NK)-cell leukemia. (medscape.com)
Bone marrow4
- Leukemia is a form of cancer that affects your blood cells, bone marrow, and other related tissues. (healthline.com)
- LEUKEMIAS, LYMPHOMAS and BONE MARROW CANCERS: Cancers of the blood cells that make up the immune system. (upstatecordbloodbank.com)
- Leukemia is a cancer of the blood or bone marrow.It is a form of cancer that affects the body's ability to make healthy blood cells. (rxharun.com)
- Acute myeloid leukemia is cancer that impacts the blood and bone marrow with a rapid progression. (drugbank.com)
Chemotherapy7
- The chemotherapy drug regimens were dominated by Hyper-CVAD regimen sales, totaling $1.8 billion and linker regimen sales totaling $1.13 billion sales in acute lymphocytic leukemia market. (powershow.com)
- Introduction: Mold-active primary antifungal prophylaxis (PAP) is widely recommended in neutropenic patients (pts) with newly diagnosed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) who undergo remission-induction chemotherapy (RIC). (confex.com)
- Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses. (medscape.com)
- Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. (medscape.com)
- The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia. (medscape.com)
- PRIMARY OBJECTIVES: I. Determine maximum tolerated dose (MTD) of MEK162 (MEK inhibitor MEK162 ) in patients with RAS-mutated acute myeloid leukemia ( AML ) when combined with sequential induction chemotherapy (3 +4 ) as measured by development of grade 3-4 dose-limiting toxicities (DLT). (mycancergenome.org)
- The purpose of this study is to compare the effectiveness of two multi-agent chemotherapy regimens using different dosages of cytarabine to eliminate all detectable leukemia. (stanford.edu)
Classification1
- Before 2008, the diagnosis of BAL was based on a score system proposed by the European Group for the Immunological Classification of Leukemias (EGIL) which could differentiate from other kinds of acute leukemia. (wikipedia.org)
Type of leukemia2
- Hairy cell leukemia-variant is an extremely rare and unique type of leukemia (cancer) that was once grouped with another type but is now considered a separate condition. (healthline.com)
- Acute lymphoblastic leukemia (ALL ) - is the most common type of leukemia in young children. (rxharun.com)
Disease4
- Acute undifferentiated leukemia (AUL) is extremely rare, and little is known about the frequency of this disease. (medscape.com)
- It's a chronic form of leukemia, meaning it's typically a more slowly developing form of the disease. (healthline.com)
- 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
- Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia. (ucdenver.edu)
Therapy in acute1
- Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. (medscape.com)
Diagnosis1
- This diagnosis should not be made in patients with known chronic myeloid leukemia (CML) who progress to the blast phase with features of MPAL. (medscape.com)
Types of leukemia3
- Let's take a look at the basics of HCL-V and how it's different from other types of leukemia. (healthline.com)
- BAL has similar symptoms to other types of leukemia, but they are usually more serious. (wikipedia.org)
- The hybrid gene product ABL/BCR is an oncogene which could lead several types of leukemia including BAL. (wikipedia.org)
Subtypes1
- The survival rates vary by age: 85% in children and 50% in adults.Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and acute biphenotypic leukemia. (rxharun.com)
Aggressive3
- The rearrangement of MLL are related with different kinds of aggressive acute leukemias. (wikipedia.org)
- In total, our work uncoveres that T-ALLs are more aggressive and have higher numbers of leukemia stem cells when compared with B-ALL and mixed phenotypic ALL. (refine.bio)
- Furthermore, analysis of our biphenotypic B/T-ALL suggests that B cell pathways lock cells in less aggressive and lower stem cell fates and are dominant in regulating these processes when T cell pathways are co-regulated within ALL cells. (refine.bio)
Adult7
- Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364. (medscape.com)
- Myeloid markers in adult acute lymphocytic leukemia. (medscape.com)
- Treatment of adult acute lymphoblastic leukemia. (medscape.com)
- Treatment of 218 adult acute lymphoblastic leukemias. (medscape.com)
- Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (medscape.com)
- Short course high dose mitoxantrone with high dose cytarabine is effective therapy for adult lymphoblastic leukemia. (medscape.com)
- Cytarabine with high-dose mitoxantrone induces rapid complete remissions in adult acute lymphoblastic leukemia without the use of vincristine or prednisone. (medscape.com)
Chimeric1
- Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
FLT32
- As well, data showed a gilteritinib-driven inhibition of the receptor tyrosine kinase AXL which is known to modulate the activity of FLT3 in acute myeloid leukemia. (drugbank.com)
- The interest in FLT3 transmembrane tyrosine kinases was raised when studies reported that approximately 30% of the patients with acute myeloid leukemia presented a mutationally activated isoform. (drugbank.com)
Stem2
- We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
- In my project I would like to investigate the role of haematopoietic stem cells (HSCs) bias in the development of MLL-induced acute leukaemias during ageing. (ox.ac.uk)
Immature1
- Acute leukemia - is characterized by a rapid increase in the number of immature blood cells. (rxharun.com)
Markers1
- [ 4 ] Cases of acute leukemia that may be classified in another category based on genetic or clinical features are also excluded (eg, AML with translocation t(8;21) and expression of multiple B-cell markers). (medscape.com)
Malignant2
- In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
- Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (rxharun.com)
Therapeutics3
- Acute Lymphocytic / Lymphoblastic Leukemia Market - The acute lymphoblastic leukemia therapeutics market is segmented based on the existing regimens and drugs, pipeline drugs, and geography. (powershow.com)
- Acute Lymphocytic Leukemia Therapeutics Market worth $3.88 Billion by 2020 - The acute lymphocytic leukemia therapeutics market was valued at $1.96 billion in 2010 and is expected to reach $3.88 billion by 2020, at a CAGR of 5.21% between 2015 and 2020. (powershow.com)
- Acute Lymphocytic/Lymphoblastic Leukemia Market worth $3.780.3 Million by 2020 - The "Acute Lymphocytic/Lymphoblastic Leukemia Therapeutics Market - (Pipeline Forecast & Market Forecast in G8 Countries) (2010 - 2020)" analyzes and studies the major market drivers, restraints, and opportunities in the U.S., Canada, U.K., France, Germany, Italy, Spain, and Japan. (powershow.com)
Diagnoses1
- Only about 2% of leukemia diagnoses are HCL. (healthline.com)
Abnormalities1
- Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been reported. (wikipedia.org)
Blood5
- One rare form of leukemia is hairy cell leukemia (HCL) , named for the hair-like filaments found on affected white blood cells. (healthline.com)
- Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
- In addition, newborns with DS frequently develop transient leukemia (TL), which is characterized by the presence of megakaryoblasts in the blood which disappear during the first 1-3 months of life. (nih.gov)
- Chronic leukemia - is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (rxharun.com)
- In myeloid or myelogenous leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (rxharun.com)
Clinical1
- The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
Patients2
- Primary or Secondary acute myeloid leukemia (AML) Patients in first of second Morphological Complete Remission (CR), Morphological Complete Remission with incomplete hematologic recovery (CRi), or Morphologic Leukemia-free State (MLFS) as defined by the European LeukemiaNet (ELN) recommendations for AML Response Criteria (Dohner, 2017). (uchicagomedicine.org)
- As noted earlier, patients with acute lymphoblastic leukemia (ALL) may present with fever without any other evidence of infection. (medscape.com)
Cytarabine1
- Giving MEK inhibitor MEK162, cytarabine, and idarubicin may be an effective treatment for acute myeloid leukemia. (mycancergenome.org)