Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
A partial denture attached to prepared natural teeth, roots, or implants by cementation.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Non-fatal immersion or submersion in water. The subject is resuscitable.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Failure in built environment with loss of functional integrity.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
The rate dynamics in chemical or physical systems.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Proteins prepared by recombinant DNA technology.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
The accumulation of an electric charge on a object
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
The plan, delineation, and location of actual structural elements of dentures. The design can relate to retainers, stress-breakers, occlusal rests, flanges, framework, lingual or palatal bars, reciprocal arms, etc.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
Elements of limited time intervals, contributing to particular results or situations.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The characteristic 3-dimensional shape and arrangement of multimeric proteins (aggregates of more than one polypeptide chain).
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Proteins found in any species of bacterium.
Computer-based representation of physical systems and phenomena such as chemical processes.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
A denture replacing one or more (but not all) natural teeth. It is supported and retained by underlying tissue and some or all of the remaining teeth.
A computer simulation developed to study the motion of molecules over a period of time.
Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.
Established cell cultures that have the potential to propagate indefinitely.
The process by which the CYTOPLASM of a cell is divided.
Disruption of the non-covalent bonds and/or disulfide bonds responsible for maintaining the three-dimensional shape and activity of the native protein.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Compounds containing the -SH radical.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
The sum of the weight of all the atoms in a molecule.
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The characteristic three-dimensional shape of a molecule.
The relationships of groups of organisms as reflected by their genetic makeup.
The thermodynamic interaction between a substance and WATER.
Methods of creating machines and devices.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.
An essential amino acid that is physiologically active in the L-form.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
An artificial replacement for one or more natural teeth or part of a tooth, or associated structures, ranging from a portion of a tooth to a complete denture. The dental prosthesis is used for cosmetic or functional reasons, or both. DENTURES and specific types of dentures are also available. (From Boucher's Clinical Dental Terminology, 4th ed, p244 & Jablonski, Dictionary of Dentistry, 1992, p643)
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The ability of a protein to retain its structural conformation or its activity when subjected to physical or chemical manipulations.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
Transport proteins that carry specific substances in the blood or across cell membranes.
Any method used for determining the location of and relative distances between genes on a chromosome.
A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.
An essential amino acid. It is often added to animal feed.
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
A representation, generally small in scale, to show the structure, construction, or appearance of something. (From Random House Unabridged Dictionary, 2d ed)
Literary and oral genre expressing meaning via symbolism and following formal or informal patterns.
Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Proteins obtained from ESCHERICHIA COLI.
Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
The transference of a heart from one human or animal to another.
A commonly used prosthesis that results in a strong, permanent restoration. It consists of an electrolytically etched cast-metal retainer that is cemented (bonded), using resins, to adjacent teeth whose enamel was previously acid-treated (acid-etched). This type of bridgework is sometimes referred to as a Maryland bridge.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
The process of cleaving a chemical compound by the addition of a molecule of water.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
The large subunit of the eubacterial 70s ribosome. It is composed of the 23S RIBOSOMAL RNA, the 5S RIBOSOMAL RNA, and about 37 different RIBOSOMAL PROTEINS.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.
An essential amino acid that is required for the production of HISTAMINE.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Protein modules with conserved ligand-binding surfaces which mediate specific interaction functions in SIGNAL TRANSDUCTION PATHWAYS and the specific BINDING SITES of their cognate protein LIGANDS.
Proteins produced from GENES that have acquired MUTATIONS.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.
Macromolecular complexes formed from the association of defined protein subunits.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Biological actions and events that support the functions of the CARDIOVASCULAR SYSTEM.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.
One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista.
Proteins found in any species of fungus.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Genotypic differences observed among individuals in a population.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.
Arthropods of the class ARACHNIDA, order Araneae. Except for mites and ticks, spiders constitute the largest order of arachnids, with approximately 37,000 species having been described. The majority of spiders are harmless, although some species can be regarded as moderately harmful since their bites can lead to quite severe local symptoms. (From Barnes, Invertebrate Zoology, 5th ed, p508; Smith, Insects and Other Arthropods of Medical Importance, 1973, pp424-430)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Fetzer, Leland (2005). San Diego County Place Names A to Z. San Diego: Sunbelt Publications. p. 107. Lower Otay Dam washed out ... The Great Vermont Flood of 1927 which destroyed over 1200 bridges in Vermont, and one of the biggest floods in its history. The ... Fetzer, Leland (2005). San Diego County Place Names A to Z. San Diego: Sunbelt Publications. p. 144. Sweetwater Dam was damaged ... Rinaldi, Giancarlo (12 August 2008). "A flood which swept away bridges". BBC News. Canada Un experto asegura en el juicio que ...
Kemp, Emory Leland. (1999), "The Wheeling Suspension Bridge: A Pictorial Heritage." Pictorial Histories Publishing Company, ... suspension bridges and railroads. He built the Wheeling Suspension Bridge, the longest suspension bridge in the world from 1849 ... A Popular Notice of Suspension Bridges, With a Brief Description of the Wire Bridge Across the Schuykill, Fairmount. ... Bridges and their builders. New York, Dover Publications. p.210 "APS Member History". search.amphilsoc.org. Retrieved 2021-04- ...
"Leland Olds, 1890-1960" (PDF). Gale Group. Retrieved 23 December 2019. Fourth Report - Un-American Activities in California - ... 98 (Lincoln Bridge), 113-114 (organization). Retrieved 18 October 2018. Guide to Subversive Organizations and Publications (And ... Scott Nearing Leland Olds Editors: E.J. Costello (1920-1922) Carl Haessler (1922-1940) Bureau Chiefs: Louis P. Lochner (Berlin ... Eugene Lyons Maud Leonard McCreery Alfred Maund Harvey O'Connor Jessie Lloyd O'Connor Leland Olds Frank L. Palmer Julia ...
Built in the mid-17th century, Glanworth Bridge is a narrow 13-arch bridge, and one of the oldest remaining examples in the ... Leland, Mary (28 August 1998). "Trevor novel to be filmed in Cork". The Irish Times. Retrieved 4 December 2020.. ... "Glanworth Bridge, Glanworth, County Cork". Buildings of Ireland. National Inventory of Architectural Heritage. Retrieved 29 ... "New life for oldest bridge". Independent News & Media. 12 January 2012. "Glanworth station" (PDF). Railscot - Irish Railways. ...
Leland[who?] records[when?] the organised trading of woollen cloth in a market that took place on a bridge over the Aire, at ... Finding the bridge at Kirkstall broken down, Fairfax crossed the Aire at Apperley Bridge, and came on to Woodhouse Moor, from ... The south end of the street had a river crossing but the earliest recorded bridge, from which its name is derived (bridge gate ... By 1536, when John Leland visited it, he was able to report of it that it was a pretty market town which stood most by clothing ...
Stolp Island with Leland Tower from New York St. Bridge. Detail of Memorial Bridge figure Memory. View of Stolp Island historic ... The plan also included a pedestrian bridge to connect the banks of the river. Also in the works is a plan to modify or ... There is also the Leland Tower, a former hotel which was the tallest building in Illinois outside of Chicago and is on the ... Goddess of Victory statue on Memorial Bridge, built c. 1931. In background is entrance to Hollywood Casino, c. 1993. ...
... at Hawford Bridge. Salwarpe, in Leland's time, was called Salop. The celebrated Earl of Warwick, Richard Beauchamp, was born ... The name is also spelled Salwarp, and in the time of John Leland was recorded as Salop. Since 2003, Salwarpe has shared a ...
ISBN 978-0-8027-1707-8. Roth, Leland M. (1982). A Concise History of American Architecture. Westview Press. p. 337. ISBN 978- ... "Steven Holl Receives Approval for Kennedy Center Pedestrian Bridge". ArchDaily. July 31, 2016. Retrieved May 9, 2018. "War or ... and a pedestrian bridge over Rock Creek Parkway. The architect is Steven Holl, with assistance from architectural firm BNIM. ...
Leland reaches the bridge, and Gallo kills him with the sedative. When Bower and Nadia confront him, Gallo opens the shutters ... He encourages them to band together, and the trio flees into a barricaded chamber, where they find a cook named Leland. Leland ... Leland flees, and Manh is cornered by the mutant leader. Manh kills the leader but is killed by a mutant child he hesitates to ... Leland gases the group, intending to eat them, but Bower convinces him the reactor must be stabilized. As they search the ship ...
The Sundøy Bridge connects the mainland to the northeastern part of the island of Alsta and the Helgeland Bridge connects it to ... The administrative centre of the municipality is the village of Leland. Other villages in Leirfjord include Bardalssjøen and ... The large Helgeland Bridge is partly located in the municipality, connecting it to Alstahaug Municipality and the town of ...
Leland, Mary (1999). The lie of the land: journeys through literary Cork. Cork University Press. p. 161. ISBN 978-1-85918-231-4 ... "The Other End of the Bridge". Kirkus Reviews. 4 January 1960. Retrieved 30 March 2020. "She Didn't Say No". Irish Film ... Troy, Una (1960). The Other End of the Bridge. Heinemann. Johnson, C. W. (8 January 1961). "Irish Feuding Becomes Frolic". ... Kirkus Reviews described her 1959 novel The Other End of the Bridge as "Funny in its presentation but not in its intent," ...
In western Leland, the road followed Fletcher Road and Village Road. After Leland School Road, the highway continued straight ... Two proposals involve the construction of a new vertical-lift bridge, while two others detail a fixed-span bridge. One vertical ... The Cape Fear Memorial Bridge was completed in 1969 providing a second bridge into the city of Wilmington. On September 11, ... 1969, US 76 was rerouted across the bridge, abandoning its former alignment along US 421 and the Isabel Holmes Bridge. US 76 ...
Johns Bridge, in the nearby Cathedral Park neighborhood. Upon arriving at the secluded area, Leland held Taylor captive and ... Leland buried Taylor's body in a shallow grave under a pile of driftwood. On August 11, 1949, Leland was arrested for ... Leland then killed Taylor when he struck her on the head with a steel bar multiple times and stabbed her with a knife. He then ... At his trial, Leland pleaded not guilty by reason of insanity. His trial began on October 4, 1949, and on November 11, he was ...
163-177, ISBN 978-1-84383-333-8 Leland, J. (1907), The Itinerary of John Leland in England and Wales, I-III (repr. ed.), London ... on Wakefield Bridge, as the latter was attempting to flee the destruction of his father's army. John, Lord Clifford, crying "by ... when John Leland published his Itinerary. Leland wrote that "for killing of men at this bataill [Clifford] was caullid the ... Leland 1907, p. 40. Cokayne 1913, p. 293. Lander 1961, p. 134 n.55. Clay 1905, p. 372. Spence 1959, p. 8. Lander 1976, p. 141. ...
Leland mentions the ruins in 1535 as 'the diche and mines of an old castelle". Bridges mentions that a part of the wall was ... The manor house appears to have survived long after the castle was pulled down and is mentioned by Bridges in 1445. By the mid ... Bridges, John (1791). The History and Antiquities of Northamptonshire: Compiled from the Manuscript Collections of the Late ... Learned Antiquary John Bridges, Esq. By the Rev. Peter Whalley, Late Fellow of St. John's College, Oxford. [Printed at the ...
"The Bridge", itself, is contextualized by John Leland, "Singles", Spin, 1988 Dec;4(9):112. Tony Best, interviewer, "Musician ... "Let's Get Small", itself, is discussed by John Leland, "Singles", Spin, 1985 Sep;1(5):33, and by Kip Lornell & Charles C. ... Daz Dillinger, Kurupt & Jewell, "Bitches Ain't Shit", The Chronic (Death Row, 1992) / MC Shan, "The Bridge", Down by Law (Cold ... "The Bridge." A rock musician, Colin Wolfe had befriended Dre working long hours for Dre at Ruthless Records, which had first ...
At the foot of Gravelly Hill was the River Tame, which was spanned by Salford Bridge. Salford Bridge was first mentioned as ... John Leland described the area as "by sandy ground, better wooded than fertile of wheat ... the soil is sandy and good for ... Britain's longest bridge, Bromford Viaduct starts here, carrying the M6 to Junction 5, Castle Bromwich. It has long been a ... although a bridge is believed to have been at this location since 1290. Nearby is Fort Dunlop, former home of Dunlop Rubber, a ...
The bridge, built in 1869, was the final link in the transcontinental railroad that made travel possible from the East Coast to ... The city was named for Jane Stanford, née Lathrop, wife of Leland Stanford. On September 6, 1869, four months after the golden ... The development abuts, and is named after, the site of the San Joaquin Railroad Bridge at Mossdale crossing, which was the ... The Western Pacific Railroad bridge across the San Joaquin river was finished to-day [September 6th], and three trains of cars ...
Bridge (east branch) Downtown Auto Service Station SciTech Hands On Museum Downer Place Bridge (east branch) Linden & Lake ... A third major hotel, Leland Tower, was constructed across the street in 1928 and was operated by the same family as Hotel ... When it opened, Hotel Leland was the tallest building in Illinois outside out Chicago. The Rapp and Rapp Paramount Theatre ... Assell's Photo Shop Barefoot Charley's Diner Leland Tower Illinois Bell Columbia Conservatory of Music Aurora Elks Lodge No. ...
J.A. Griffith Bridge. Just over 1,500 feet (460 m) later, SR 5 departs the concurrency to the north. The other three highways ... After a curve to the east, they pass Harmony-Leland Elementary School and Lindley Middle School. They curve to the southeast, ... Immediately after a slight curve to the east is an intersection with US 1/SR 4 (Deans Bridge Road). US 1 joins the concurrency ... Approximately 1 mile (1.6 km) southeast of the creek, US 78/SR 8 cross over the Tallapoosa River on the Bently Bridge. About ...
Cross the bridge over the Merced River and climb the short ridge. From the granite slabs on the ridge ascend the Northeast ... California Governor Leland Stanford visited Yosemite in 1865, and he and James Hutchings visited Nevada Fall. Stanford didn't ...
There was a bridge here by the time that John Leland toured England in 1538-43. John Ogilby's Britannia Atlas of 1675 records a ... In 1814 the stone bridge was widened on its downstream side. to almost double its former width. In contrast with the older ... timber bridge here that he called "Emley Bridg". In 1718 the road was made into a turnpike and at some stage the timber bridge ... Jervoise, Edwyn (1932). The Ancient Bridges of Mid and Eastern England. III. Westminster: The Architectural Press for the SPAB ...
Both bridges date to at least the 1530s when they were mentioned by antiquary John Leland. These bridges were wooden in ... it is known that the area would have experienced travelers with two bridges built over the River Rhondda at Porth, the Pont ...
To the west of the road from Rossington Bridge into Doncaster, Leland passed the "largely impenetrable morass of bog and fen ... as I remember is called Rossington Bridge…. The soil about Doncaster hath very good meadow, corn and some wood. As Leland ... One of the earliest references to Potteric Carr comes from the itinerary of Leland c.1540: Before I came to the town, I passed ... which can be seen in Dr Derick Riley's air photographs of nearby Bawtry Road and Hurst Lane where the Roman Till Bridge Lane ...
John Leland wrote at about this time: "Ther stondithe now but one tower, and that partly broken. As I went by I saw carts ... carienge stone thens to amend Persore (Pershore) Bridge about ii miles of. It is set on the tope of a hill full of wood, and a ...
The present bridge has nine arches and was noted by the early 16th-century antiquary John Leland. In the 1970s Jennifer ... The bridge is a Grade II* listed building and forms an important part of the view from the historic adjacent landscape garden ... After the bridge over the Cherwell was built (see below) the village was called Heyford ad Pontem. It was called Heyford ... Lower Heyford had two toll-gates: one at Heyford Bridge and the other at the east end of the village. The road was disturnpiked ...
... author of Sleeping with the Enemy Leland Sage - professor at UNI and historian Robert James Waller - author of The Bridges of ... "Leland L. Sage , Rod Library". library.uni.edu. Archived from the original on May 2, 2019. Retrieved May 2, 2019. Risberg, Eric ... Munson, Kyle (March 13, 2017). "'Bridges of Madison County' made Robert James Waller famous but didn't define him". Des Moines ...
CS1 maint: discouraged parameter (link) John Leland (1768). The itinerary of John Leland, publ. by T. Hearne, To which is ... "Palladian Bridge (443307)". Images of England. Archived from the original on 18 October 2012. Historic England. "Porter's Lodge ... John Leland, the 16th century antiquarian and traveller, noted some stone mining activity in Combe Down as he passed by. By ... John Leland, the 16th century antiquarian and traveller, wrote in the 1500s that he approached Bath from Midford "...And about ...
Carter's death was the impetus for Charles Kettering and Henry M. Leland to develop the electric self-starter. Carter was ... pneumonia as a result of injuries he sustained when he tried to hand crank start a car stranded on the Belle Isle bridge near ...
The Ken Curtis Bridge, connecting the highway to Buhl, was constructed over the Snake River in 1968. In 1997, the Idaho ... SH-46 originally terminated at the I-84 interchange in Wendell, while the remaining 15 miles (24.1 km) of the Rex Leland ... SH-46 crosses over the Snake River on Ken Curtis Bridge near Clear Lake Park and enters Gooding County, ascending from the ... "Repair work on Ken Curtis Bridge begins Monday" (Press release). Idaho Transportation Department. May 5, 2015. Retrieved ...
Wilkinson, Leland (1999). "Statistical methods in psychology journals: Guidelines and explanations". American Psychologist. 54 ... Conover, William J.; Iman, Ronald L. (1981). "Rank Transformations as a Bridge Between Parametric and Nonparametric Statistics ...
John Leland Center for Theological Studies. *Liberty University. *Lynchburg College. *Mary Baldwin University ...
On 12 August 1939, the westbound City of San Francisco derailed from a bridge in Palisade Canyon, between Battle Mountain and ... Leland Stanford (1885-1890). *Collis P. Huntington (1890-1900). *Charles Melville Hays (1900-1901) ...
Each cross-bridge attachment and detachment cycle is powered by the splitting of one molecule of adenosine triphosphate (ATP). ... Gerber, Marcus; Parry, J.; Robin, L.; Dibble, Leland E.; Greis, Patrick E.; Burks, Robert T.; LaStayo, Paul C.; March (2007). " ... With more cross bridges remaining attached there is greater force production in the muscle. Examples of activities involving ... When in a concentric exercise, shortening of a muscle occurs as the myosin and actin cross bridges repeatedly attach and detach ...
Leland Stanford Mansion. *Los Angeles. *Los Encinos. *Malakoff Diggins. *Marconi Conference Center ...
Calvin B. Bridges', Nature 143, 191-192 (04 Feb 1939). *^ "Percy Williams Bridgman". NNDB.com. Retrieved 24 April 2012. He was ... He was awarded the 2001 Nobel Prize in Physiology or Medicine along with Leland Hartwell and Tim Hunt for their discoveries of ... Calvin Bridges (1889-1938): American geneticist, known especially for his work on fruit fly genetics.[49] ...
Gilliam's initial casting choices were Nick Nolte as James Cole and Jeff Bridges as Jeffrey Goines, but Universal objected.[5] ... Leland Goines. *David Morse as Dr. Peters. *Jon Seda as Jose. *Christopher Meloni as Lt. Halperin ... Gilliam, who first met Bruce Willis while casting Jeff Bridges' role in The Fisher King (1991), believed Willis evoked Cole's ...
Lyons, Francis Stewart Leland (1973), Ireland since the famine, Fontana, p. 30. ... Social vulnerability and ecological fragility: building bridges between social and natural sciences using the Irish Potato ...
Edward's nickname probably came from his black armour, and was first used by John Leland in the 1530s or 1540s.[284] ... Ancillary structures included new town halls, houses, bridges, and tithe barns.[238] Shipbuilding improved with the use of the ...
Leland Stanford Mansion. *Los Angeles. *Los Encinos. *Malakoff Diggins. *Marconi Conference Center ...
Leland noted the building, upon entering Birmingham, in 1538 as a "mansion house of tymber". It is thought to have been ...
"The Care of Old Bridges", The Times, 30 October 1911, p. 9; and "Portinscale Bridge", The Manchester Guardian, 1 November 1911 ... in the 1530s John Leland wrote of it as "a lytle poore market town".[24] By the second half of the century copper mining had ... opened at a site diagonally opposite Greta Bridge in 1898.[115] In 1951 a new secondary modern school was built at Lairthwaite ... Rawnsley led successful campaigns to save the medieval Greta and Portinscale bridges from replacement with ferro-concrete ...
Leland Stanford Mansion. *Los Angeles. *Los Encinos. *Malakoff Diggins. *Marconi Conference Center ...
The most important of these is that it has sympathetic strings and a less curved bridge and fingerboard. Thus, the performer ... Trans.William H. Halverson and Leland B. Sateren. Lincoln: University of Nebraska Press, 1991. Print. ... His cool, almost ambient approach is typical of Norwegian jazz, although recently there have been moves to build bridges with ...
Lyons, Francis Stewart Leland (1973), Ireland since the famine, Fontana. *. McCorkell, John (2010), McCorkell Line, retrieved ... "Social vulnerability and ecological fragility: building bridges between social and natural sciences using the Irish Potato ... "Social vulnerability and ecological fragility: building bridges between social and natural sciences using the Irish Potato ...
Leland, John (August 5, 1996). "Grieving At Ground Zero". Newsweek Magazine. Retrieved January 14, 2010.. ... a land witness on the Beach Lane Bridge in Westhampton Beach, New York, and a witness on a boat near Great Gun Beach.[1]:243- ... even more so if the occupants were in an enclosed bridge or cabin.[1]:94 Further, review of the Islip radar data for other ...
Mike Gray, T. S. Cook and James Bridges (1979). *Bo Goldman (1980) ... David Leland (1987). *Shawn Slovo (1988). *Nora Ephron (1989). *Giuseppe Tornatore (1990) ...
In 1915 Morgan, Sturtevant, Calvin Bridges and H. J. Muller wrote the seminal book The Mechanism of Mendelian Heredity.[22] ... 2001: Leland H. Hartwell / Tim Hunt / Paul Nurse. *2002: Sydney Brenner / H. Robert Horvitz / John E. Sulston ... Morgan, Thomas Hunt; Alfred H. Sturtevant, H. J. Muller and C. B. Bridges (1915). The Mechanism of Mendelian Heredity. New York ... He wanted to attract the best people to the Division at Caltech, so he took Bridges, Sturtevant, Jack Shultz and Albert Tyler ...
Protesters built a floating bridge to Turtle Island, considered sacred ground, and 400 gathered near the bridge, some crossing ... Michael Leland, Iowa Public Radio (September 15, 2016). "Bakken pipeline opposition presents petitions to U.S. Justice ... "Protesters vow to "reclaim" land, bridge Thursday". Retrieved November 28, 2016.. *^ Dowd, Katie (November 30, 2016). "Standing ... The bridge is about a mile (1600 m) south of where the pipeline developer plans to drill. According to the sheriff's department ...
1867-1944) by Governor Leland Stanford, who was shown her picture by her father. As Lewis first told the story in 1925, ...
Echo Bridge is a notable 19th-century masonry arch bridge with views of the river and Hemlock Gorge in Hemlock Gorge ... Samuel Leland Powers, politician, U.S. Congressman. *Alexander Hamilton Rice, politician, Massachusetts governor, U.S. ...
Leland Stanford Mansion. *Los Angeles. *Los Encinos. *Malakoff Diggins. *Marconi Conference Center ...
Scudder, Samuel H.; William M. Davis; Charles W. Woodworth; Leland O. Howard; Charles V. Riley; Samuel W. Williston (1989). The ... "Ormond Beach Flying US Flags On Granada Bridge T0 Mark 9\17". NewsDaytonaBeach.com. WNDB Local News First. 2013. Retrieved 14 ...
"A bridge too far gone". The Economist. August 9, 2007.. *^ "Future Interstates and Potential Interstate Corridors". Interstate- ... Office of California State Senator Leland Yee. Archived from the original on October 19, 2012. Retrieved July 16, 2012. State ... including the state's most famous highway bridge, the Golden Gate Bridge). These toll facilities, along with several high- ... However, there are four toll roads in Southern California, and eight toll bridges in the San Francisco Bay Area ( ...
Fetzer, Leland (2005). San Diego County Place Names A to Z. San Diego: Sunbelt Publications Inc. pp. 44-45. ISBN 978-0-932653- ... A part of Lake Hodges is crossed by Interstate 15 via the Lake Hodges Bridge. Often this part of the lake is dry. ... Stanford, Leland G. (1978). "Devil's Corner and Oliver S. Witherby". Journal of San Diego History. San Diego History Center. 24 ...
Leland Orser The Die Is Cast (DS9) A Founder disguised as a Romulan Tal Shiar colonel in 2371. He was in command of Enabran ... Kirk enters the Bridge and takes Maltz prisoner at phaser-point, promising to "kill" him later for not piloting the Bird-of- ... She was killed on the Bridge by one of V'ger's probes, but her appearance was later given to another V'ger probe, which was put ... He tests for the operations manager (ops) position on the Bridge, but believes that his friend, Ensign Sito Jaxa, is more ...
Blue Water Bridge, a twin-span bridge (Port Huron, Michigan, and Point Edward, Ontario, but the larger city of Sarnia is ... Many individuals, including Ransom E. Olds, John and Horace Dodge, Henry Leland, David Dunbar Buick, Henry Joy, Charles King, ... "Bridge Magazine. Retrieved December 3, 2011.. *^ Bell, Dawson (November 18, 2011). "Michigan Supreme Court hands Gov. Rick ... International Bridge (Sault Ste. Marie, Michigan, and Sault Ste. Marie, Ontario). *St. Clair River Railway Tunnel (Port Huron ...
Leland Stanford Mansion. *Los Angeles. *Los Encinos. *Malakoff Diggins. *Marconi Conference Center ...
Dumbarton Bridge. *Bayshore Freeway. *Interstate 280. *State routes *Route 82. *Route 109 ... Leland Stanford Jr.. *Leland Stanford. *Jane Stanford. Related. *History of Stanford University ...
Despite this, they were eventually defeated by a larger Revolutionary force at the Battle of Moore's Creek Bridge. The area ...
Leland Bridge invites you to join our annual fundraising event - Leland Bridge Night. Celebrate the year of the Pig with ... Leland Bridge 為您邀請了 Leland 高中十二年級輔導 員 Ms. Brenda Stone 將教您如何使用這個申請大學的 重要工具. ... 5:00-8:00 PM in Leland Cafeteria. It is an unforgettable event you dont want to miss. Please see tickets and flyer for ... 2018 leland bridge night. Date: 2/3/
Today we honor Private First Class Leland Cary. He served in the United States Marine Corps, 1st Marine Division from December ... Retired marine talks man off the ledge of a bridge in St. Louis. ... PFC Leland Cary. Posted 1:02 pm, May 24, 2013, by Web Staff ... Today we honor Private First Class Leland Cary.. He served in the United States Marine Corps, 1st Marine Division from December ...
This is the place for questions about bidding, scoring, conventions, how to play, rubber bridge, duplicate, 4-deal scoring ( ... officially known as Contract Bridge, is played all over the world. ... Bridge Card Game. The bridge card game, officially known as Contract Bridge, is played all over the world. This is the place ... You can only declare honors in Rubber Bridge. Honors are not credited in Duplicate Bridge or Chicago or Party Bridge scoring. ...
Governments of all levels have to meet the challenge of using resources wisely to provide facilities that are safe, secure and represent the communities in which they are built. Our experience includes new and renovated federal and county courthouses, office buildings, hospitals and clinics, border stations, and detention facilities, city halls, and police and fire stations. We provide engineering solutions that are practical, economical, well suited to preferred local construction practices and material availabilities, and sustainable.
Bruton has its packhorse bridge, dovecote and famous twin-towered church. Near Castle Cary is Cadbury Castle, whose summit ... The Leland Trail is a 28-mile (45.1 km) footpath in Somerset, England. It was named after the antiquary John Leland, and runs ... The Leland Trail links with the Monarchs Way at Ilchester, and the Liberty Trail and the River Parrett Trail at Ham Hill. "The ... The exact route taken by Leland over much of South Somerset may never be known but the remaining records of the time form the ...
Summer Bridge Activities(TM): Bridging Grades Seventh to Eighth prepares your rising eighth grader... ... Original Summer Bridge Activities Bridging Grades 7 8 by Rainbow Bridge available in Trade Paperback on Powells.com, also read ... Bridge Rainbow. Author:. Michele D. Van Leeuwen. Author:. Rainbow Bridge Publishing. Author:. Leland Graham. Author:. Summer ... Rainbow Bridge. Subject:. summer; summer learning; summer learning loss. Subject:. workbooks; language arts; math. Subject:. ...
Fetzer, Leland (2005). San Diego County Place Names A to Z. San Diego: Sunbelt Publications. p. 107. Lower Otay Dam washed out ... The Great Vermont Flood of 1927 which destroyed over 1200 bridges in Vermont, and one of the biggest floods in its history. The ... Fetzer, Leland (2005). San Diego County Place Names A to Z. San Diego: Sunbelt Publications. p. 144. Sweetwater Dam was damaged ... Rinaldi, Giancarlo (12 August 2008). "A flood which swept away bridges". BBC News. Canada Un experto asegura en el juicio que ...
HB2886: Leland Branham Memorial Bridge; designating as Route 72 bridge over Toms Creek within Scott Co. ... HB640: Low-water bridge; Dickenson County to transfer ownership therof in Town of Pound to VDOT. ...
Was there lots of bridge playing going on, too?. Goldberg:. Yes, lots of bridge. And Menzel played bridge a lot, and Leland ... I saw you mentioned in your other interview something about Leland Cunningham being the telephone operator, and having great ... At the Shapley parties, would they include bridge over in a corner for some people or not? ... and we would play bridge with the Shapleys in the evening. Yes, there was a lot of that. ...
The Bridge alum Ted Levine and The Good Wifes Ismael Cruz Cordova have joined the Season 4 cast of Showtime drama series Ray ... The Bridge alum Ted Levine and The Good Wifes Ismael Cruz Cordova have joined the Season 4 cast of Showtime drama series Ray ... Additional TV credits include an eight-season run on Monk as Captain Leland Stottlemeyer. Other upcoming TV projects include a ... Levine, repped by Kass Management, most recently starred opposite Diane Kruger and Demian Bichir in FXs The Bridge. ...
Leland Whitey George was a known soldier that fought in the battle. He entered the war on January 1, 1942. He went to ... They were shipped from the Cow Palace near the Golden Gate Bridge in San Fransico. It took twenty two days to get to Australia ... LELAND WHITEY GEORGE by daughter Verla Cole and granddaughter Megan George. Verla tells about their background: My dad, ...
Leland refers to a contemporary bridge and to an older wooden bridge that had existed at Kingston since the 13th century. This ... Hampton Court Bridge (road) Kingston Bridge, London. Grid reference: TQ177693 Kingston Railway Bridge (rail) ... Until Putney Bridge was opened in 1729, Kingston Bridge was the only crossing of the river between London Bridge and Staines ... Kingston Bridge is a road bridge at Kingston upon Thames in south west London, England, carrying the A308 across the River ...
a resident of Embarcadero Oaks/Leland on Jan 9, 2013 at 3:27 pm. If I lived on or around Newell I would want that bridge ... Is anything being done for the 101 bridge over the creek? If the other bridges are fixed, the floods will just move to bridge. ... The size of the bridge should remain the same.. Any increase in the width of the bridge, length of the bridge, alignment with ... Posted by Bridges, tough to know. a resident of Midtown on Jan 9, 2013 at 12:47 pm. Leave the bridge as IT IS I believe. ...
By playing the only African-American and female bridge officer on the fictional starship crew, Nichelle inspired both girls and ... But Leland, his staff and the experts from NASA and private industry took the risk and reaped the rewards. In every session I ... My name is Leland Melvin. I am an engineer, snowboarder, chemist, musician, former NFL player, astronaut, and the Associate ... Leland Melvin, NASAs associate administrator for education and a two-time shuttle astronaut himself, created a wonderful ...
A bridge that runs through Jim Hensons childhood hometown of Leland, Mississippi, has been officially named The Rainbow ... Connection Bridge in his honor. (If you dont get the reference, Rainbow Connection is the name of an Oscar-nominated ballad ...
WPD says traffic heading out of Wilmington toward Leland will be backed up for a while. ... Accidents tie up traffic on Cape Fear Memorial Bridge. WILMINGTON, NC (WWAY) - Two accidents involving seven vehicles have ... slowed traffic on the Cape Fear Memorial Bridge.. Wilmington Police say the accidents happened around 8:15 a.m. Investigators ...
Mickey Leland Hunger Fellows explore both field and policy components of development work, and the link between the two. In ... Leland, Policy. During the course of their service, Mickey Leland Hunger Fellows explore both field and policy components of ... Having the opportunity to work with them has also helped me to bridge the field year and the policy year through their ... I am also fortunate to have two former Leland Fellows within my unit. Anne-Claire Hervy is the Associate Vice-President for ...
that make Leland unique 120. PLACE Human Characteristics. Human Characteristics The human characteristics of a place come from ... They include bridges, houses, and parks. Human characteristics of place also include land use, density of population, language ... They include bridges, houses, and parks. Human characteristics of place also include land use, density of population, language ...
She now resides in Leland, N.C. with her husband Lawrence F. Wright. She is the mother of two sons and two stepsons and ... We are not a sanctioned American Contract Bridge League game by choice, so we dont give ACBL master points and try to keep it ... will be giving bridge lessons at the Cazenovia Library on Tuesday Mornings, starting Sept. 14. A new wrinkle has been added; at ... and win overall and East/West honors at our duplicate bridge game at the Library on August 17. Jean and Bill Young won North/ ...
Current progress in bridge engineering : a German viewpoint  Jackson, Susan Kay (Massachusetts Institute of Technology, 1982) ... Garren, Scott L. (Scott Leland) (Massachusetts Institute of Technology, 1991) * Creation of identity in the Chilean nueva ...
The Leland Opening.. As announced in last weeks TRAVELER, the Leland was opened under the management of its former proprietor ... For the bridge and bonds, and those voting against the building of the bridge as aforesaid, shall have written or printed on ... the Leland will certainly be crowded. It was during Mr. Pattersons regime that the new part of the Leland was built, which ... That such a bridge is a necessity will be granted by everybody having occasion to cross this uncertain stream. It moreover will ...
Detachable aneurysm neck bridge (I) US6346098B1 (en) 2000-03-07. 2002-02-12. The Board Of Trustees Of The Leland Stanford ... Detachable aneurysm neck bridge (II) DE10117099A1 (en) * 2000-08-02. 2002-02-21. Aesculap Ag & Co Kg. Medical Device, method ... Detachable aneurysm neck bridge (III) US6558367B1 (en) * 1997-10-17. 2003-05-06. Micro Therapeutics, Inc.. Catheter system and ... Detachable aneurysm neck bridge (I) US6936055B1 (en) 1997-08-05. 2005-08-30. Scime Life Systems, Inc.. ...
... (pronounced my-bridge) is best known for settling a bet for railroad baron Leland Stanford, arranging a ...
Break-in at Bridge Grill in Sunset Beach SUNSET BEACH-Town police are investigating a break-in and theft of items at Bridge ... Saul Hernandez Ruiz, 27, of 8963 Fish Road, Leland, was charged with trafficking cocaine, possession with intent to manufacture ... They set up checkpoints at Mount Misery Road, Grey Bridge Road, Long Beach Road, Longwood Road, Holden Beach Road, N.C. 904, ... 20-26, ACE deputies patrolled Winnabow, Longwood, Calabash, Holden Beach, Supply, Southport and Leland. ...
The LELAND Initiative. The United States are also interested in Africa. In 1996, they launched the Leland Initiative which, ... In addition, Lane has served as a principal informant for broader US Government approaches to bridge the Digital Divide, ... He has served as the Coordinator of the Leland Initiative since its inception in 1996; this is the USAID Bureau for Africa ... Policy, Governance; First Internet gateway in some countries set up by the Leland Initiative. ...
A bridge was not built until 1872, when the 2,750-foot-long (840 m) Union Pacific Missouri River Bridge was completed. ... It was here on May 10, 1869, that Leland Stanford drove The Last Spike (or golden spike) that joined the rails of the ... In July 1869, the H&SJ finished the Hannibal Bridge in Kansas City which was the first bridge to cross the Missouri River. This ... In 1869, the Kansas Pacific Railway started building the Hannibal Bridge, a swing bridge across the Missouri River between ...
v. Nashville Bridge Co., 670 S.W.2d 841, 846 (Ky. 1984), this Court held that a three-month time limitation in the FAA for ... of Trustees of Leland Stanford, Jr. Univ., 489 U.S. 468, 477 n.6 (1989), state courts have routinely applied their own ...
STANDING: Judy Bridge, Betsy Prescott, Judy Goldman, Paul Oppenheimer, Amanda Fisk. 37 THE PUBLIC SPEAKING CLUB SEATED Miss ... l9I2-1923 Leslie Leland-I923-i928 Dr. Morris Mitchell-T928-T934 Wendell Norvell-I934-I935 .Karl W. Bigelow-T935-I936 M. ... THIRD ROW: Carol Ossola, Judy Bridge, Emmy-lou Gray, Laura Damon, Patty Dodd, Amanda Fisk, Betsy Prescott, Gail Stumpf, Joanna ... SECOND ROW: Carmina Stewart, Judy Bridge, Y Emmy Lou Gray, .lack Merkley, Gabby Stevens, David Stewart, Don Wallens. THIRD ROW ...
The bridge itself was preserved, brought to the Illinois Railway Museum two days later as three 15-foot wide loads. IRM planned ... Between Leland Avenue (where the spur from the Buena Interchange Yard connected to the Ls North Side Main Line) and Howard ... The through girder bridge with ballasted deck that carried the freight lead over Montrose Avenue was removed on September 26, ... As part of the elevation project, the line from Leland to Howard was expanded into a four-track main line with separated local ...
Seven Bridges Genomics Inc.. Methods and systems for aligning sequences US20150139946A1 (en) * 2013-10-19. 2015-05-21. ... The Board Of Trustees Of The Leland Stanford Junior University. Identification and use of circulating nucleic acid tumor ... Seven Bridges Genomics Inc.. Methods and systems for aligning sequences US9902992B2 (en) 2012-09-04. 2018-02-27. Guardant ... Seven Bridges Genomics Inc.. Systems and methods for using paired-end data in directed acyclic structure ...
  • It was named after the antiquary John Leland, and runs from King Alfred's Tower in Penselwood, southwest to Ham Hill Country Park near Yeovil. (wikipedia.org)
  • It is named after John Leland, who visited South Somerset during the years 1535-1543. (wikipedia.org)
  • According to 16th century antiquarian John Leland , the bridge existed in the centuries when Anglo-Saxon England existed (after Roman Britain and before 1066). (wikipedia.org)
  • New York Times reporter John Leland thought he knew how to write about the "oldest old" - people 85 and up. (nextavenue.org)
  • John Leland (antiquary) claimed that the area around Maidenhead's present town centre was a small Roman settlement called Alaunodunum . (wikipedia.org)
  • Leland Cheuk discusses his novel The Misadventures of Sulliver Pong , dark humor, cancer, morally corrupt characters, and his mother. (therumpus.net)
  • An incident involving a Leland Middle School student who went missing Thursday was caused by a "perfect storm," according to Jessica Swencki, spokesperson for Brunswick County Schools. (wilmington.net)
  • Marco Polo Bridge Incident. (writework.com)
  • Eadweard Muybridge (pronounced my-bridge) is best known for settling a bet for railroad baron Leland Stanford , arranging a series of cameras along the horse's path with trip-wires triggered by the advancing animal. (nndb.com)
  • The railroad opened for through traffic on May 10, 1869 when CPRR President Leland Stanford ceremonially drove the gold "Last Spike" (later often referred to as the " Golden Spike ") with a silver hammer at Promontory Summit . (wikipedia.org)
  • A quiet man who rarely complained, Millmore chose not to join an unsuccessful worker strike because his pregnant wife was due, and the railroad company rewarded his loyalty with a transfer to the safer occupation of bridge construction. (theotherstories.org)
  • The following week, just two days after his son was born, at his new job, Millmore's safety harness was chafing his crotch, and while adjusting it, he inadvertently undid the belt and plummeted to his death, off the railroad bridge that traverses what is now Bordirtoun River. (theotherstories.org)
  • While many other summer workbook series are available, Summer Bridge Activities continues to be the series that teachers recommend most. (powells.com)
  • SUNSET BEACH-Town police are investigating a break-in and theft of items at Bridge Grill, 305 Sunset Blvd. N. (brunswickbeacon.com)
  • WILMINGTON, NC (WWAY) - Two accidents involving seven vehicles have slowed traffic on the Cape Fear Memorial Bridge. (wilmington.net)
  • The State Highway Patrol is responding to a reported hit and run on the Brunswick County side of the Cape Fear Memorial Bridge. (wilmington.net)
  • Stone repairs are needed upon the bridge over the Arkansas River south of town, and also upon the road leading thereto. (ausbcomp.com)
  • DOG the Bounty Hunter's son Leland Chapman has revealed he's gained weight due 'injuries taking their toll. (thesun.co.uk)
  • Leland responded: 'Yes, my injuries took a toll, hard to work out when you can't even walk. (thesun.co.uk)
  • Leland refers to a contemporary bridge and to an older wooden bridge that had existed at Kingston since the 13th century. (wikipedia.org)
  • A wooden bridge was erected across the river in about 1280 to replace the ferry in what was then the village of South Ellington. (wikipedia.org)
  • The mediaeval timber bridge fell victim to destructions during the Wars of the Roses and Wyatt's rebellion . (wikipedia.org)
  • During the early medieval period timber was used, but from the 12th century stone (and later brick) bridges became more common, with the piers sometimes supported by a timber raft. (historicengland.org.uk)
  • Where medieval bridges have been altered in later centuries, original features are sometimes concealed behind later stonework, including remains of earlier timber bridges. (historicengland.org.uk)
  • The winner was John Burges Watson, with a design for a bridge of three equal arches. (wikipedia.org)
  • Multi-span bridges are structures of two or more arches supported on piers. (historicengland.org.uk)
  • Most stone or brick bridges were constructed with pointed arches, although semicircular and segmental examples are also known. (historicengland.org.uk)
  • Despite the 19th and later 20th century widening and the modern replacement of some infill over its arches, it retains extensively its original medieval fabric, its length makes it one of the longest surviving medieval multi-span bridges in England. (historicengland.org.uk)
  • The neatly-executed segmental arches supporting that limited widening and the simple manner of their insertion into the medieval bridge are a good example of the physical accommodation of those pressures into the often medieval infrastructure that carried our highways. (historicengland.org.uk)
  • Summer Bridge Activities is the original workbook series developed to help parents support their children academically during the summer months. (powells.com)
  • The award-winning Summer Bridge Activities(R) workbook series is aligned to Common Core State Standards and was developed to help parents support their children academically year-round. (powells.com)
  • The Bridge alum Ted Levine and The Good Wife 's Ismael Cruz Cordova have joined the Season 4 cast of Showtime drama series Ray Donovan in recurring roles. (deadline.com)
  • In his new book, Happiness Is a Choice You Make: Lessons From a Year Among the Oldest Old, Leland expands on the newspaper series and weaves in his experiences with his elderly mother. (nextavenue.org)
  • Now 79, Leland was a young pharmacist on the island when he was swept up in the aftermath. (patterico.com)
  • The exhibition gathers an eclectic range of artwork that spans thousands of years from the museum's collections, including a sixth-century Egyptian medallion, a lukasa memory board from the Republic of Congo and a lithograph of a tree colored in by young Leland Stanford Jr. (stanford.edu)
  • Throughout the 1960's and 1970's scores of motorists using the Sunshine Skyway Bridge claimed to see a young blonde lady dressed in a tight T-shirt in an off-white or tan outfit poised to jump off of one of the main spans. (crazedfanboy.com)
  • When Sheriff's Deputies would investigate, no trace of the young lady could be found, either at the top of the bridge, or in the waters below. (crazedfanboy.com)
  • As Leland delved deeper, however, he realized the people in this age group were more than the sum of their problems. (nextavenue.org)
  • According to Leland, people in this age group don't try to do "a little of everything" - they focus on the interests that bring them the most satisfaction. (nextavenue.org)
  • After hearing an overview of Cape Fear Community College's marine tech and marine bioscience programs, the group was whisked across the bridge to visit Manufacturing Methods, a fast-growing machining and fabrication business in Leland Industrial Park. (wilmingtonbiz.com)
  • The InnovateNC group ended its tour at BCC's Leland Center, where visitors viewed the college's brand-new incubator space and heard about BCC's aquaculture program. (wilmingtonbiz.com)
  • The Thames Path crosses the river here and the bridge is the end point for the Thames Down Link long distance footpath from Box Hill station . (wikipedia.org)
  • During the course of their service, Mickey Leland Hunger Fellows explore both field and policy components of development work, and the link between the two. (hungercenter.org)
  • Kingston Bridge is a road bridge at Kingston upon Thames in south west London , England, carrying the A308 across the River Thames . (wikipedia.org)
  • A crowd of community members from Palo Alto and East Palo Alto jammed into the theater at the Lucie Stern Community Center to voice their opinions on the proposed replacement Newell Road bridge on Tuesday night, Jan. 8. (paloaltoonline.com)
  • Saul Hernandez Ruiz, 27, of 8963 Fish Road, Leland, was charged with trafficking cocaine, possession with intent to manufacture, sell and deliver cocaine, manufacturing cocaine and possession of drug paraphernalia. (brunswickbeacon.com)
  • They set up checkpoints at Mount Misery Road, Grey Bridge Road, Long Beach Road, Longwood Road, Holden Beach Road, N.C. 904, Blue Banks Loop Road and Old Ocean Highway. (brunswickbeacon.com)
  • [3] The Great West Road to Reading , Gloucester and Bristol was diverted over the new bridge. (wikipedia.org)
  • The well-documented construction, widenings and eventual bypassing of this substantial medieval bridge on what is now an unclassified road shows clearly the considerable development of the highway system and its objectives during the medieval and post-medieval periods. (historicengland.org.uk)
  • A two lane bridge is not a "super bridge" -- when I heard this I thought it must be 4 lanes or something. (paloaltoonline.com)
  • After sharing that Kona came home on the day of the late June post, Jamie explained that she and Leland originally believed that the dog sprained his leg. (thesun.co.uk)
  • [6] The successive bridges contributed greatly to Kingston's success as a medieval market town . (wikipedia.org)
  • Previously, it had kept to the north bank and crossed the Thames by ford at Cookham , and the medieval town of Maidenhead grew up between the new bridge and the bottom of Castle Hill. (wikipedia.org)
  • The medieval and 19th century bridge at Wadebridge survives well. (historicengland.org.uk)
  • Its importance in this regard is enhanced by the survival of a second such medieval bridge contemporary with Wadebridge on the same north coastal route at Bideford in north Devon. (historicengland.org.uk)
  • A good corpus of supporting historical documentation surrounds the original construction of the bridge, allowing, for instance, identification of the stone source and providing an excellent example of a medieval endowment to fund a bridge's maintenance costs. (historicengland.org.uk)
  • The historical context also adds particular importance to the bridge's physical structure by bracketing its construction date, allowing its deployment of single arch rings, broad piers and largely slate-built construction to be closely dated and to assist in the analogous dating of other more poorly-dated medieval bridges. (historicengland.org.uk)
  • When trying to find your purpose, "Kickboxing might not be a great choice, but painting, political activity, time with family or passing along your skills to the next generation can be a reason for living at any age," Leland wrote. (nextavenue.org)
  • If it is to be replaced with a ped bridge, the cost of removing the existing bridge (the point of the project) would likely be strictly a local expense. (paloaltoonline.com)
  • The bridge led to the growth of Maidenhead as a market town and a major stopping point for coaches on the journeys between London and Bath and the town became populated with numerous inns . (wikipedia.org)
  • Cobain's life became frustrating too as he was moved from one relative to another and even at one point was homeless and lived under a bridge. (essaysexperts.com)
  • Montacute is the next "port of call" en route, and the slightly more difficult terrain means well over two hours to complete the next 4 miles (6.4 km). (wikipedia.org)
  • We rent and sell Portable Sectional Barges that are used in bridge construction, general marine construction, dredging, and other projects where it's necessary to float heavy construction equipment, materials or men. (poseidonbarge.com)
  • HIE-Bridge was developed by and for healthcare providers to securely meet their unique health information exchange needs," said Cheryl Stephens, PhD, President and CEO of CHIC. (fiercehealthcare.com)
  • Any increase in the width of the bridge, length of the bridge, alignment with Newell in EPA is irrelevant to the flooding issue and will inevitably increase traffic and jeopardize the safety of hundreds of children who bike to school daily on Newell. (paloaltoonline.com)
  • WPD says traffic heading out of Wilmington toward Leland will be backed up for a while. (wilmington.net)
  • Destroying or defending the few bridges of the Thames gave power - having no nearby bridges would particularly hinder mounted armies. (wikipedia.org)
  • Writing on this topic also gave Leland, now 58, new insights into how he wants to live out his later years. (nextavenue.org)
  • L eland Bridge invites you to join our annual fundraising event - Leland Bridge Night. (google.com)
  • Closing the bridge would increase impacts on University Avenue and cut-through of other neighborhoods. (paloaltoonline.com)
  • The most conspicuous remnant of this former operation still extant today are the sections of the single-track concrete elevated structure between Leland Avenue and Montrose Avenue near Wilson station -- partially in use by southbound Purple Line Express trains, partially demolished, and partly abandoned -- although other small artifacts and vestiges exist as well. (chicago-l.org)
  • The corporation planned to erect a cast-iron bridge, and an architectural competition was held with a prize of 100 guineas. (wikipedia.org)
  • Mrs. E. McCarty won high score in auction bridge, and Mrs. O. F. Elphlck was awarded first prize in Chinese checkers. (newspapers.com)
  • The Leland Trail is a 28-mile (45.1 km) footpath in Somerset, England. (wikipedia.org)
  • The Leland Trail links with the Monarch's Way at Ilchester, and the Liberty Trail and the River Parrett Trail at Ham Hill. (wikipedia.org)
  • The first stone was laid by the Earl of Liverpool at a ceremony on 7 November 1825 [9] and the bridge was opened by the Duchess of Clarence (the future Queen Adelaide) on 17 July 1828. (wikipedia.org)
  • a deviance between the approved design and the actual finished construction of the bridge connecting the main campus with the student services building has been discovered. (fullcoll.edu)
  • We work to shine a light on stories that build bridges, tear down walls, and speak truth to power. (therumpus.net)
  • The groom has been a member of the state highway patrol force on the San Francisco-Oakland Bay Bridge for the past two years. (newspapers.com)
  • U.S. Sen. Edward M. Kennedy's Oldsmobile sedan veered off a narrow bridge on Chappaquiddick Island, an extension of the resort island of Martha's Vineyard off Massachusetts, and plunged into a moonlit pond 50 years ago Thursday. (patterico.com)
  • Four players are necessary for a game of bridge, but after the bidding only three actually play. (answers.com)
  • Leland anthophilous hindi one act play pdf does not match his avenging Tink 24 math game app recklessly? (88077.tk)
  • sharp Title12pcs 100 epub lagunas en el derecho una controversia sobre el derecho y feet collective Reusable Silicone Soap Mold Pink durian Square Handmade Soaps Moulds Microwave, Oven, Refrigerator and Dishwasher Safe play To CartThere is a account being to take. (thegreensofjericho.net)
  • The courts became involved in 1813 but were overtaken by events in January 1814, when part of the bridge collapsed due to a severe frost. (wikipedia.org)
  • With 12 weeks worth of activities, completing Summer Bridge ActivitiesTM is the perfect way to keep skills sharp all summer long! (powells.com)
  • Featuring two extra weeks of cross-curricular activities, all new social studies material, integrated fitness and character development exercises, updated reading lists, and extension activities to encourage outdoor learning, the award-winning Summer Bridge Activities™ is the perfect way to keep skills sharp all summer long and prepare your child for the upcoming school year. (powells.com)
  • Would a new bridge that solved the problem of flooding necessarily increase the current number of vehicles using the new bridge? (paloaltoonline.com)
  • The current Maidenhead Bridge , a local landmark, dates from 1777 and was built at a cost of £19,000. (wikipedia.org)
  • Until Putney Bridge was opened in 1729, Kingston Bridge was the only crossing of the river between London Bridge and Staines Bridge . (wikipedia.org)
  • Just a couple of thinking points: The new bridge would have to be wider because the existing one is functionally obsolete, and state and federal funds are fortunately not available to local agencies to replace obsolete facilities in kind. (paloaltoonline.com)
  • Kingston Bridge is on the reach above Teddington Lock and close to and downstream of the mouth of the Hogsmill River, a minor tributary of the Thames. (wikipedia.org)
  • The bridge abutments and revetting of the river banks also form part of the bridge. (historicengland.org.uk)
  • Mr. McCabe there worked on a canal and with his comrades fought his way to Jackson, Mississippi, where he took part in the battle of that city and also in the engagement at Black River Bridge. (iagenweb.org)
  • Signals from the bridge circuit are amplified and digitized and applied to a computer which includes an adaptive pattern recognition algorithm which is responsive to hand-state vectors for recognizing letter beacons in hand-space. (justia.com)
  • for this purpose many urban bridges had houses or chapels on them, and some were fortified with a defensive gateway. (historicengland.org.uk)
  • As Leland interacted with the subjects of his book, he came to a new understanding about his relationship with his mother, for whom he acts as a caregiver. (nextavenue.org)
  • It changed into a two-way relationship where we were doing things for each other," Leland said. (nextavenue.org)