AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Laryngeal NeoplasmsCarcinoma, Squamous CellLarynxVocal CordsVocal Cord ParalysisLaryngectomyHead and Neck NeoplasmsGastroesophageal RefluxGlottisEsophageal pH MonitoringFundoplicationEsophagusEsophagitisCarcinoma, NeuroendocrinePeriodicals as TopicAccess to InformationJournal Impact FactorBibliometricsPublishingPeer Review, ResearchDideoxynucleosidesInfusions, Intra-ArterialTreatment OutcomeFluorine RadioisotopesPositron-Emission TomographyAntineoplastic Combined Chemotherapy ProtocolsLarynx, ArtificialOrgan Sparing TreatmentsSpeech, AlaryngealSpeech, EsophagealChileArchivesBiological Science DisciplinesPubMedDirectories as TopicDeath, SuddenAutopsyBereavementCoroners and Medical ExaminersForensic PathologyCause of DeathTerminology as TopicLiterature, ModernConnecticutNasal CavitySalivary GlandsThyroid GlandRadiotherapy, Intensity-ModulatedOtolaryngologyCellular PhoneWisconsinMiddle Ear VentilationOtitis Media with EffusionProfessional Practice LocationHearing Loss, Conductive
Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Larynx: A tubular organ of VOICE production. It is located in the anterior neck, superior to the TRACHEA and inferior to the tongue and HYOID BONE.Vocal Cords: A pair of cone-shaped elastic mucous membrane projecting from the laryngeal wall and forming a narrow slit between them. Each contains a thickened free edge (vocal ligament) extending from the THYROID CARTILAGE to the ARYTENOID CARTILAGE, and a VOCAL MUSCLE that shortens or relaxes the vocal cord to control sound production.Vocal Cord Paralysis: Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, the VAGUS NERVE and branches of LARYNGEAL NERVES. Common symptoms are VOICE DISORDERS including HOARSENESS or APHONIA.Laryngectomy: Total or partial excision of the larynx.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Glottis: The vocal apparatus of the larynx, situated in the middle section of the larynx. Glottis consists of the VOCAL FOLDS and an opening (rima glottidis) between the folds.Esophageal pH Monitoring: Analysis of the HYDROGEN ION CONCENTRATION in the lumen of the ESOPHAGUS. It is used to record the pattern, frequency, and duration of GASTROESOPHAGEAL REFLUX.Fundoplication: Mobilization of the lower end of the esophagus and plication of the fundus of the stomach around it (fundic wrapping) in the treatment of GASTROESOPHAGEAL REFLUX that may be associated with various disorders, such as hiatal hernia. (From Dorland, 28th ed)Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Esophagitis: INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Access to Information: Individual's rights to obtain and use information collected or generated by others.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Dideoxynucleosides: Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.Infusions, Intra-Arterial: Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Fluorine Radioisotopes: Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Larynx, Artificial: A device, activated electronically or by expired pulmonary air, which simulates laryngeal activity and enables a laryngectomized person to speak. Examples of the pneumatic mechanical device are the Tokyo and Van Hunen artificial larynges. Electronic devices include the Western Electric electrolarynx, Tait oral vibrator, Cooper-Rand electrolarynx and the Ticchioni pipe.Organ Sparing Treatments: Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function.Speech, Alaryngeal: Methods of enabling a patient without a larynx or with a non-functional larynx to produce voice or speech. The methods may be pneumatic or electronic.Speech, Esophageal: A method of speech used after laryngectomy, with sound produced by vibration of the column of air in the esophagus against the contracting cricopharyngeal sphincter. (Dorland, 27th ed)ChileArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.Autopsy: Postmortem examination of the body.Bereavement: Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.Coroners and Medical Examiners: Physicians appointed to investigate all cases of sudden or violent death.Forensic Pathology: The application of pathology to questions of law.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Literature, ModernConnecticutNasal Cavity: The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Otolaryngology: A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.WisconsinMiddle Ear Ventilation: Ventilation of the middle ear in the treatment of secretory (serous) OTITIS MEDIA, usually by placement of tubes or grommets which pierce the TYMPANIC MEMBRANE.Otitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.Professional Practice Location: Geographic area in which a professional person practices; includes primarily physicians and dentists.Hearing Loss, Conductive: Hearing loss due to interference with the mechanical reception or amplification of sound to the COCHLEA. The interference is in the outer or middle ear involving the EAR CANAL; TYMPANIC MEMBRANE; or EAR OSSICLES.

Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas. (1/1167)

Laryngeal papillomas are benign tumors caused by human papillomaviruses types 6 and 11. This study addressed alterations in levels of signal transduction from the epidermal growth factor receptor (EGFR) in papillomas and cultured papilloma cells compared to normal tissue and cells. Mitogen-activated protein kinase (MAPK) was activated to a greater extent, phosphotyrosine was more abundant, and EGFR was overexpressed in laryngeal papillomas compared to normal laryngeal epithelium by Western blot analysis. The EGFR was 3 times more abundant in cultured papilloma cells than in normal laryngeal cells by Scatchard analysis and Western blot, without gene amplification or an increase in steady-state levels of mRNA. Following stimulation with EGF, a significant portion of the EGFR was recycled to the surface in papilloma cells, whereas in normal cells, it was not. Tyrosine kinase activity and activation of MAPK was more responsive to epidermal growth factor stimulation in papilloma cells than in uninfected primary laryngeal cells. PD153035, a specific inhibitor of the EGFR, and an EGFR-specific antibody that blocks ligand binding completely abrogated basal MAPK activation by endogenous ligands in laryngeal papilloma cells. These results demonstrated that infection of laryngeal epithelium by low-risk human papillomaviruses elevates the EGFR by posttranslational mechanisms, increasing its responsiveness to ligand-mediated activation. They also showed that MAPK activation in laryngeal papillomas depends upon ligand-mediated EGFR stimulation.  (+info)

Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. (2/1167)

Glutathione S-transferases (GSTs) are involved in detoxification of reactive metabolites of carcinogens and, therefore, could be potentially important in susceptibility to cancer. The associations between larynx cancer risk and GSTM3 and GSTP1 gene polymorphisms, either separately or in combination with GSTM1 and GSTT1 gene polymorphisms, were evaluated using peripheral blood DNA from 129 cancer patients and 172 controls, all regular smokers. The frequencies of GSTM3 AA, AB, and BB genotypes were 60.5%, 36.4%, and 3.1% in cases and 72.7%, 24.4%, and 2.9% in controls, respectively. The frequencies of GSTP1 AA, AG, and GG genotypes were 48.1%, 40.3%, and 11.6% in cases and 50.0%, 37.2%, and 12.8% in controls, respectively. Multivariate logistic regression analyses did not reveal any association between the GSTP1 (AG or GG) genotype and larynx cancer [odds ratio, 1.1; 95% confidence interval (CI), 0.7-2.0]. In contrast, a significant increase in risk was related to the GSTM3 (AB or BB) genotype (odds ratio, 2.0; 95% CI, 1.1-3.4). The combined GSTM3 (AB or BB) and GSTM1-null genotype conferred a 4-fold risk (95% CI, 1.6-10.1) of larynx cancer as compared with the combined GSTM3 AA and GSTM1-positive genotype. However, the effect of GSTM3 (AB or BB) genotype was similar among individuals with GSTM1-positive or GSTM1-null genotypes.  (+info)

Concordant induction of cyclin E and p21cip1 in differentiated keratinocytes by the human papillomavirus E7 protein inhibits cellular and viral DNA synthesis. (3/1167)

Productive infections by human papillomaviruses (HPVs) occur only in differentiated keratinocytes in squamous epithelia in which the HPV E7 protein reactivates the host DNA replication machinery to support viral DNA replication. In a fraction of the differentiated keratinocytes, E7 also posttranscriptionally induces p21Cip1, which is distributed in a mutually exclusive manner with unscheduled cellular DNA synthesis. In this study, double immunofluorescence labeling unexpectedly revealed that E7 caused a concordant accumulation of both cyclin E and p21Cip1 to high levels in patient papillomas and in organotypic cultures of primary human keratinocytes. The induction of cyclin E is mutually exclusive with unscheduled cellular DNA synthesis or abundant viral DNA. These novel virus-host interactions in differentiated keratinocytes are in contrast to previous observations made in submerged proliferating cultures, in which HPV E7 induces cyclin E and overcomes p21Cip1 inhibition of S-phase entry. We propose that an appropriately timed induction of cyclin E/cyclin-dependent kinase 2 by HPV E7 in postmitotic cells enables S-phase reentry and HPV DNA amplification, whereas prematurely induced cyclin E stabilizes p21Cip1 protein, which then inhibits cyclin E/cyclin-dependent kinase 2. Consequently, cyclin E and p21Cip1 both fail to turn over, and DNA synthesis does not occur.  (+info)

Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. (4/1167)

PURPOSE: To determine the utility of pretreatment computed tomography (CT) for predicting primary site control in patients with supraglottic squamous cell carcinoma (SCC) treated with definitive radiotherapy (RT). MATERIALS AND METHODS: Pretreatment CT studies in 63 patients were reviewed. Minimum length of follow-up was 2 years. Local recurrence and treatment complications resulting in permanent loss of laryngeal function were documented. Tumor volume was calculated using a computer digitizer, and pre-epiglottic space (PES) spread was estimated. The data were analyzed using a combination of Fisher's exact test, logistic regression modeling, and multivariate analyses. Five-year local control rates were calculated using the product-limit method. RESULTS: Local control rates were inversely and roughly linearly related to tumor volume, although there seemed to be a threshold volume at which primary site prognosis diminished. Local control was 89% in tumors less than 6 cm3 and 52% when volumes were > or =6 cm3 (P = .0012). The likelihood of maintaining laryngeal function also varied with tumor volume: 89% for tumors less than 6 cm3 and 40% for tumors > or =6 cm3 (P = .00004). Pre-epiglottic space involvement by tumor of > or =25% was associated with a reduced chance of saving the larynx (P = .0076). Multivariate analyses revealed that only tumor volume independently altered these end points. CONCLUSION: Pretreatment CT measurements of tumor volume permits stratification of patients with supraglottic SCC treated with RT alone (which allows preservation of laryngeal function) into groups in which local control is more likely and less likely. Pre-epiglottic space spread is not a contraindication to using RT as the primary treatment for supraglottic SCC.  (+info)

Sternothoracotomy for combined coronary artery bypass grafting and left upper lobectomy in a patient with low-lying tracheostoma. (5/1167)

A 64-year-old man had a low-lying tracheostoma and presented with unstable angina and a mass in the pulmonary left upper lobe. Simultaneous coronary revascularization and resection of the lung neoplasm were completed through a sternothoracotomy (clam-shell) incision. The advantages of this approach include excellent exposure to the mediastinum and the lung fields, and the option of using both internal thoracic arteries for bypass grafting.  (+info)

Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (6/1167)

Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction.  (+info)

The difference between delayed extubation and tracheostomy in post-operative sleep apnea after glossectomy or laryngectomy. (7/1167)

BACKGROUND: Patients with cancer of the tongue or larynx require glossectomies or laryngectomies and subsequent reconstruction. These procedures remove part of the patient's upper airway. In cancer of the tongue, the removed part of the airway is substituted by a flap of their skin. Post-operatively, it is possible that the patients have problems respiring comfortably. In addition to this, long surgical procedures may simply interfere with their circadian rhythm. To elucidate the possible change in their post-operative respiration, we monitored the patient's respiratory pattern with an apnea monitor. METHODS: We attached an apnea monitor to the patients and recorded their respiratory pattern and arterial oxygen saturation. The patients were monitored for a total of five days: three days prior to the operation, one day before the operation, the day of operation, two days after, and on the fourth day after the operation. The period of monitoring was from 8:00 p.m. to 6:00 a.m. the next morning. RESULTS: Sixteen patients completed this study. The patients whose tube was extubated after glossectomy showed frequent apnea, low mean oxygen saturation and low comfort score as compared to the patients with tracheostomy after laryngectomy. Because two failed cases of free skin flap were among the former, it is possible that the frequent apnea is a factor of failed free skin graft after glossectomy and laryngectomy. CONCLUSION: Further studies are required to improve the patient's respiration during their sleep after tracheal extubation in glossectomy.  (+info)

Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase. (8/1167)

The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]]. The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine). Here, we have determined the protective effect of overexpression of allelic variants of hGSTP1-1, through stable transfection in HepG2 cells, against (+)-anti-BPDE-induced DNA modification. Clonal transfectants of HepG2 cells corresponding to the three allelic variants of hGSTP1-1 [(I104,A113), (V104,A113), and (V104,V113), denoted hGSTP1(IA), hGSTP1(VA), and hGSTP1(VV), respectively] with similar levels of hGSTP1 protein were identified and characterized for their GST activity and (+)-anti-BPDE-induced DNA modification. The glutathione S-transferase activity toward (+)-anti-BPDE was significantly higher (approximately 3.0-3.6-fold) in cells transfected with hGSTP1(VA) [HepG2(VA)] and hGSTP1(VV) [HepG2(VV)] compared with hGSTP1(IA) transfectant [HepG2(IA)]. The formation of (+)-anti-BPDE-DNA adducts was significantly reduced in HepG2(VA) and HepG2(VV) cells compared with cells transfected with insert-free vector (HepG2-vect). Maximum protection against (+)-anti-BPDE-induced DNA damage was afforded by the hGSTP1(VV) isoform. The results of this study indicate that the allelic variants of hGSTP1-1 significantly differ in their ability to provide protection against (+)-anti-BPDE-induced DNA damage. Thus, hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to tumorigenesis induced by benzo[a]pyrene.  (+info)

Thyroid Gland Involvement in Advanced Laryngeal Squamous Cell Carcinoma | Acta Medica Philippina : The National Health Science...Thyroid Gland Involvement in Advanced Laryngeal Squamous Cell Carcinoma | Acta Medica Philippina : The National Health Science...
Philippine General Hospital, University of the Philippines Manila. Objective. This study aims to determine the prevalence and pattern of thyroid gland involvement in advanced laryngeal squamous cell carcinoma and to identify factors associated with its development.. Method. Records of 118 patients who underwent laryngectomy with thyroidectomy for advanced laryngeal squamous cell carcinoma in a tertiary government hospital from January 2010 to August 2015 were reviewed. Demographic, clinical and histopathology data were obtained. The relationship of the laterality of primary tumor bulk and lobe involvement was analyzed using Fischers exact test. The association between thyroid gland invasion and other factors was analyzed using logistic regression.. Results. Thyroid gland involvement was found in 11% of the patients via direct spread in 92.3%. Single lobe involvement accounted for 61.5% of cases. There is a tendency for laryngeal squamous cell carcinoma to invade the thyroid lobe ipsilateral to ...
EGFR Immunoexpression in Laryngeal Squamous Cell CarcinomaEGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the immunohistochemical expression of EGFR in 38 cases of laryngeal squamous cell carcinomas depending on clinicopathological parameters related to prognosis. The EGFR immunoreactions have statistical significant higher values in high grade carcinomas. Although the EGFR values were superior in advanced stages lesions, the aspect was not significant EGFR may be useful in identifying the aggressive laryngeal squamous carcinomas.
Serum expression of selected miRNAs in patients with laryngeal squamous cell carcinoma (LSCC) | Diagnostic Pathology | Full TextSerum expression of selected miRNAs in patients with laryngeal squamous cell carcinoma (LSCC) | Diagnostic Pathology | Full Text
The aim of the present study was to identify specific serum miRNAs (preoperative serum samples compared to healthy controls) as potential diagnostic markers for detection in laryngeal squamous cell carcinoma (LSCC). Serum samples obtained from 66 patients with LSCC were compared with 100 healthy control subjects. Additionally, miRNA levels were evaluated to identify possible correlations with clinicopathological features. The expression of 377 miRNAs (screening set) was evaluated by microarray screening. The most differentially expressed miRNAs were validated by high-throughput real-time quantitative polymerase chain reaction (RT-qPCR) in the group of LSCC patients and healthy controls. Receiver-operator characteristic (ROC) curve analysis was conducted to evaluate the diagnostic accuracy of the highly and significantly identified deregulated miRNA(s) as potential candidate biomarker(s). According to the array analysis, eleven miRNAs revealed an altered expression profile. The levels of serum expression
MGMT promoter hypermethylation as a prognostic factor in patients with laryngeal squamous cell carcinoma | OncologyPROMGMT promoter hypermethylation as a prognostic factor in patients with laryngeal squamous cell carcinoma | OncologyPRO
Laryngeal squamous cell carcinomas (LSCC) are frequently occurring cancers with a high risk of local recurrences or second primary tumours developing within the first two years of diagnosis. A common feature of LSCC is the epigenetic inactivation of certain genes by promoter hypermethylation. In a previous study we found associations of promoter methylation with some clinical features of LSCC. The present study aimed at assessing promoter hypermethylation of CDKN2A, MGMT and MLH1 as prognostic factors in LSCC patients. ...
MGMT promoter hypermethylation as a prognostic factor in patients with laryngeal squamous cell carcinoma | OncologyPROMGMT promoter hypermethylation as a prognostic factor in patients with laryngeal squamous cell carcinoma | OncologyPRO
Laryngeal squamous cell carcinomas (LSCC) are frequently occurring cancers with a high risk of local recurrences or second primary tumours developing within the first two years of diagnosis. A common feature of LSCC is the epigenetic inactivation of certain genes by promoter hypermethylation. In a previous study we found associations of promoter methylation with some clinical features of LSCC. The present study aimed at assessing promoter hypermethylation of CDKN2A, MGMT and MLH1 as prognostic factors in LSCC patients. ...
Detection of human papilloma virus type 16 E6 mRNA in laryngeal squamous cell carcinoma by in situ hybridization | SpringerLinkDetection of human papilloma virus type 16 E6 mRNA in laryngeal squamous cell carcinoma by in situ hybridization | SpringerLink
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor in Northeast China and is frequently associated with well-established risk factors like smoking and alcohol abuse. Human papilloma
Prognostic value of cell-cycle regulators and cellular biomarkers in laryngeal squamous cell carcinoma | Menha Swellam; Lobna R...Prognostic value of cell-cycle regulators and cellular biomarkers in laryngeal squamous cell carcinoma | Menha Swellam; Lobna R...
Prognostic value of cell-cycle regulators and cellular biomarkers in laryngeal squamous cell carcinoma | Menha Swellam; Lobna R. Ezz El-Arab; Ahmed Adly | download | BookSC. Download books for free. Find books
Expression of CBY and methylation of CBY at promoter region in human laryngeal squamous cell carcinoma | TJExpression of CBY and methylation of CBY at promoter region in human laryngeal squamous cell carcinoma | TJ
You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal ...
Laryngeal NeoplasmLaryngeal Neoplasm
This page includes the following topics and synonyms: Laryngeal Neoplasm, Laryngeal Tumor, Vocal Cord Cancer, Squamous Cell Carcinoma of the Larynx, Laryngeal Cancer, Laryngeal Squamous Cell Carcinoma.
Hpv and larynx cancer. Hpv related laryngeal cancer, Hpv virus and laryngeal cancer - natural-aloevera.roHpv and larynx cancer. Hpv related laryngeal cancer, Hpv virus and laryngeal cancer - natural-aloevera.ro
The presence of RBP protein 48 positive papilloma virus morte slowly positive cases was associated with hpv and larynx cancer recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with hpv and larynx cancer recurrence hpv and larynx cancer 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine cases Figure 6. Unele studii au arătat că, în anumite cazuri hpv cancer larynx cancer laringian de etiologie HPV, genomul viral se integrează în materialul genetic al celulelor tumorale, hpv cancer larynx proteina p16 INK4A este supraexprimată în aceste cazuri, din cauza blocării proteinei pRb, ca rezultat al acțiunii proteinei virale E7 9, Totuși, privind în ansamblu situația, implicarea Hpv cancer larynx în apariția cancerelor laringiene este relativ restrânsă, însă infecția cu tulpina hpv cancer larynx este hpv laryngeal cancer corelată hpv laryngeal cancer predispoziția dezvoltării
Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical SignificanceSerum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance
Background: Laryngeal cancer is an important malignancy in head and neck area and squamous cell carcinoma(SCC) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) indifferent tumors and their correlation with tumor invasiveness has been documented. However, most studieshave evaluated MMP-2 and MMP-9 expression and few have evaluated serum levels. The aim of current studywas to evaluate serum levels in patients with laryngeal SCC compared to normal subjects and assess any relationwith tumor clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oralSCC and 20 healthy subjects were included. Serum levels of MMP-2 and MMP-9 were compared between groupsand correlations with findings including grade (T) and node involvement (N) were evaluated. Results: Patientswith laryngeal SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p=0.03) comparedto healthy subjects. Patients with higher T stage (T3,4) had
Type of Treatment Impacts Recurrence in Laryngeal SCC | Physicians Weekly for Medical News, Journals & ArticlesType of Treatment Impacts Recurrence in Laryngeal SCC | Physician's Weekly for Medical News, Journals & Articles
WEDNESDAY, Dec. 14, 2016 (HealthDay News) - For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online Nov. 30 in Head & Neck.. Aaro Haapaniemi, M.D., from Helsinki University Hospital in Finland, and colleagues analyzed a nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005. Data were included for 316 patients with initial successful therapy.. The researchers found that 22 percent of patients had laryngeal SCC recurrence. The median time to recurrence was nine months, and 90 percent occurred within 36 months following treatment. Independent prognostic factors for recurrence included the World Health Organization performance status ,0, neck metastasis at presentation, and nonsurgical treatment. Five-year overall survival was 53 percent for patients with local recurrence and 5 percent for patients with regional/distant ...
Upregulation of MiR-196a promotes cell proliferation by downregulating p27 kip1 in laryngeal cancer | Biological Research |...Upregulation of MiR-196a promotes cell proliferation by downregulating p27 kip1 in laryngeal cancer | Biological Research |...
Accumulating evidence has confirmed that miR-196a plays a critical role in tumorigenesis and tumor progression in a variety of cancers. It has been demonstrated that miR-196a is highly up-regulated in laryngeal cancer by miRNA profiling analysis. However, the functional mechanism of miR-196a in laryngeal cancer remains unclear. This study aims to explore the mechanism of miR-196a in laryngeal cancer. In the present study, we conducted qPCR analysis of miR-196a expression in human laryngeal cancer and showed that miR-196a was overexpressed in tumor-derived samples and laryngeal cancer cell lines compared with matched normal controls. Further functional analysis of miR-196a demonstrated that the inhibition of miR-196a could inhibit laryngeal cell-cycle progression and proliferation in vitro. Luciferase reporter assay and western blot confirmed that miR-196a directly targeted p27kip1. Moreover, in order to investigate whether miR-196a regulated cell growth in laryngeal cancer cells by targeting p27kip1,
Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell...Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell...
Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. - PubMed - NCBIPrognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell CarcinomaThe Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
COEXISTENCE OF SALMONELLA ENTERICA AND HUMAN EPITHELIAL CELLS-IN VITRO SYSTEM / KOEGZISTENCIJA SALMONELLA ENRERICA I HUMANIH...COEXISTENCE OF SALMONELLA ENTERICA AND HUMAN EPITHELIAL CELLS-IN VITRO SYSTEM / KOEGZISTENCIJA SALMONELLA ENRERICA I HUMANIH...
E-mail: [email protected], [email protected] Abstract. Salmonella entericais an ultimative human pathogen that causes various health problems. On the other hand, Lactobacillus plantarumhas numerous positive effects on human health. The objective of this study was to investigate the influence of enterobacteriaS. entericaLT21 on human laryngeal carcinoma cell line (HEp2). The ability of the adhesion of S. entericaLT21 as an independent culture and in combination with L. plantarum16.4 to HEp2 cells was tested as well as metabolic activity of S. entericaLT21 after adhesion to HEp2 cells. The protein content in HEp2 cells after the incubation with S. entericaLT21 was investigated and compared with the protein content in the untreated HEp2 cells. Adhesion results show better binding of S. entericaLT21 than L. plantarum16.4 when bacteria are mixed in a 1:1 and 10:1 ratios, respectively. Acetic and lactic acid in the sample of HEp2 cells incubated with S. entericaLT21 were detected, as well as lactic ...
Risk factors for laryngeal cancer - Canadian Cancer SocietyRisk factors for laryngeal cancer - Canadian Cancer Society
Risk factors for laryngeal cancer include smoking, alcohol, smoking and alcohol combined, asbestos and sulphuric acid. Learn about laryngeal cancer risk.
Bioselection-individualized Treatment Modality Selection Improves Advanced Laryngeal Cancer Survival - ONABioselection-individualized Treatment Modality Selection Improves Advanced Laryngeal Cancer Survival - ONA
Personalized treatment strategies for laryngeal cancer based on tumor response after a single cycle of neoadjuvant chemotherapy ups survival.
Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach<...Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach<...
TY - JOUR. T1 - Improving decision making in larynx cancer by developing a decision aid. T2 - A mixed methods approach. AU - Petersen, Japke F.. AU - Berlanga, Adriana. AU - Stuiver, Martijn M.. AU - Hamming-Vrieze, Olga. AU - Hoebers, Frank. AU - Lambin, Philippe. AU - van den Brekel, Michiel W. M.. PY - 2019/12. Y1 - 2019/12. KW - Patient decision aid. KW - counseling. KW - health communication. KW - larynx cancer. KW - chemoradiotherapy. KW - radiotherapy. KW - laryngectomy. KW - PATIENT-REPORTED OUTCOMES. KW - TOTAL LARYNGECTOMY. KW - NECK-CANCER. KW - SURVIVAL. KW - PRESERVATION. KW - QUALITY. KW - INFORMATION. KW - VALIDATION. KW - RADIATION. KW - TRENDS. U2 - 10.1002/lary.27800. DO - 10.1002/lary.27800. M3 - Article. VL - 129. SP - 2733. EP - 2739. JO - Laryngoscope. JF - Laryngoscope. SN - 0023-852X. IS - 12. ER - ...
High co-prevalence of genogroup 1 TT virus and human papillomavirus is associated with poor clinical outcome of laryngeal...High co-prevalence of genogroup 1 TT virus and human papillomavirus is associated with poor clinical outcome of laryngeal...
BACKGROUND The aetiology and factors leading to the progression of laryngeal cancer are still unclear. Although human papillomavirus (HPV) has been suggested to play a role, reports concerning the effect of HPV infection on tumour development are controversial. Recently, transfusion transmitted virus (TTV) was suggested to play a role in certain infections as a causative or coinfecting agent. AIMS To investigate whether the development and progression of laryngeal squamous cell carcinoma is associated with coinfection with TTV and HPV. METHODS The prevalence of TTV and HPV was investigated using the polymerase chain reaction in tissue samples from 40 healthy individuals, 10 patients with recurrent papillomatosis, five patients with papillomatosis with malignant transformation, and 25 patients with laryngeal carcinoma. The obtained prevalence data were compared and analysed statistically. RESULTS In the 11 patients with carcinoma who had metastasis or relapse there was a high rate of coinfection
Larynx Cancer Epidemiology Forecast To 2023 [Updated: 31052017] Prices from USD $2338 - BioPortfolio.comLarynx Cancer Epidemiology Forecast To 2023 [Updated: 31052017] Prices from USD $2338 - BioPortfolio.com
From BioPortfolio: DelveInsight Larynx Cancer Epidemiology Forecast To 2023 provides an overview of the epidemiology trends of Larynx Cancer in seven major markets US, France, Ger...
Larynx Cancer - Market Insights, Epidemiology and Market Forecast - 2025 : ReportsnReportsLarynx Cancer - Market Insights, Epidemiology and Market Forecast - 2025 : ReportsnReports
[70 Pages Report] Check for Discount on Larynx Cancer - Market Insights, Epidemiology and Market Forecast - 2025 report by Delve Insight. DelveInsight s Larynx Cancer - Market Insights, Epidemiology and Market Forecast -...
Larynx Cancer in India | Book an Appoinment InstantlyLarynx Cancer in India | Book an Appoinment Instantly
Larynx Cancer in India: Get health & medication advice from our expert doctors & book appointment online for Larynx Cancer instantly at Ask Apollo.
Reproducibility, reliability and validity of population-based administrative health data for the assessment of cancer non...Reproducibility, reliability and validity of population-based administrative health data for the assessment of cancer non...
Patients with comorbidities do not receive optimal treatment for their cancer, leading to lower cancer survival. Information on individual comorbidities is not straightforward to derive from population-based administrative health datasets. We described the development of a reproducible algorithm to extract the individual Charlson index comorbidities from such data. We illustrated the algorithm with 1,789 laryngeal cancer patients diagnosed in England in 2013. We aimed to clearly set out and advocate the time-related assumptions specified in the algorithm by providing empirical evidence for them.. METHODS ...
Frontiers | Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells | PharmacologyFrontiers | Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells | Pharmacology
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradiotherapy, but recurrences often occur that are associated with radioresistance. Using human SQD9 laryngeal squamous cell carcinoma cancer cells as a model, we aimed to identify metabolic changes associated with acquired radioresistance. In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. The cell cycle, clonogenicity, tumor growth in mice and DNA damage-repair were assessed. Mitochondrial DNA (mtDNA) was sequenced. In a bottom-up approach, matched glycolytic and oxidative SQD9 cells were generated using FACS-sorting, and tested for their radiosensitivity/radioresistance. We found that acquired radioresistance is associated with a shift from a glycolytic to a more oxidative metabolism in SQD9 cells. The opposite was also true, as the most oxidative fraction
IDENTIFIKACIJA PROTEINSKIH BILJEGA KOD METASTATSKOGA PLANOCELULARNOG KARCINOMA GRKLJANA I DOPRINOS POLISIJALIZACIJE NCAM...IDENTIFIKACIJA PROTEINSKIH BILJEGA KOD METASTATSKOGA PLANOCELULARNOG KARCINOMA GRKLJANA I DOPRINOS POLISIJALIZACIJE NCAM...
Laryngeal squamous cell carcinoma (LSCC) is the most common form of malignant disease in the head and neck region characterized by the frequent occurrence of metastases in the neck lymph nodes early in the disease progression. This form of cancer is characterised with numerous genetic abnormalities and changes in expression levels of proteins and glycoproteins associated with the process of carcinogenesis. Despite numerous findings molecular mechanism of metastatic disease has not yet been fully elucidated. In addition, there is increasing evidence that abnormal expression and glycosylation of proteins result of initial malignant transformation of cells, and aberrant glycosylation is one of the key events in the invasion and metastasis of many malignant diseases. In addition, there is increasing evidence indicating that abnormal expression and glycosylation of proteins is a result of cellular initial malignant transformation, and aberrant glycosylation is one of the key events in the invasion ...
Laryngeal Cancer Treatment (PDQ )Laryngeal Cancer Treatment (PDQ )
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. General Information About Laryngeal Cancer. Updated statistics with estimated new cases and deaths for 2017 (cited American Cancer Society as reference 1).. Treatment Option Overview for Laryngeal Cancer. Added subsection title and text to state that surgery and radiation therapy have been the standards for treatment of laryngeal cancer but outcome data from randomized trials are limited; underpowered studies have not fully addressed whether to use surgery or radiation (cited Iyer et al. as reference 1). Also added that selection of primary surgery versus radiation therapy-based treatment should be made in a multidisciplinary setting with consideration of disease stage, comorbidities, and functional status, including voice and swallowing outcomes and lung capacity.. Added text to state that prospective ...
Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis<...Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis<...
TY - JOUR. T1 - Treatment and survival in 10,429 patients with localized laryngeal cancer. T2 - A population-based analysis. AU - Misono, Stephanie. AU - Marmor, Schelomo. AU - Yueh, Bevan. AU - Virnig, Beth A.. PY - 2014/6/15. Y1 - 2014/6/15. N2 - BACKGROUND The objectives of this study were to identify factors associated with treatment differences, characterize changes in treatment patterns over time, and compare survival across treatment types in patients who received treatment for localized laryngeal cancer. METHODS Using the Surveillance, Epidemiology, and End Results database, we conducted a retrospective cohort analysis of patients who were treated from 1995 to 2009 for localized laryngeal cancer. Four treatment groups were defined: (1) radiation only, (2) local surgery only, (3) local surgery and radiation, and (4) open surgery with or without radiation. Variations in treatment rates between these groups were evaluated according to demographic factors, and differences in treatment rates ...
Potential role of Bcl 2 and Ki 67 expressions in predicting the response to radiotherapy of T1 and T2 clinical stages of...Potential role of Bcl 2 and Ki 67 expressions in predicting the response to radiotherapy of T1 and T2 clinical stages of...
Thesis, English, Potential role of Bcl 2 and Ki 67 expressions in predicting the response to radiotherapy of T1 and T2 clinical stages of laryngeal squamous cell carcinoma for Ezzo Eman Mohamed Hassan
Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer by E Ward, B Paigen et al.Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer" by E Ward, B Paigen et al.
To test whether the distribution of AHH inducibility is shifted toward the high end of the range in patients who had lung and laryngeal cancer, we measured this trait in 59 patients (32 lung and 27 laryngeal) who had resectable tumors and had been disease-free for a period of time. The advantage of selecting patients who were free of clinical disease was that measurement of their AHH inducibility should not have been affected by the disease state. Patient and control populations showed no difference in basal and induced AHH activity of AHH inducibility. The mean AHH inducibility in patients who had lung cancer was 3.20 +/- 0.20; in patients who had laryngeal cancer 2.96 +/- 0.18, and for all controls 3.29 +/- 0.04 (no significant difference at p = 0 05). Further analysis of the distribution of AHH inducibility in the patient group compared to controls showed no suggestion of a shift toward the higher end of the range in patients who had lung and laryngeal cancer.
Molecular and cellular alterations in tobacco smoke-associated larynx cancerMolecular and cellular alterations in tobacco smoke-associated larynx cancer
Tumours of head and neck belong to the most frequent types of cancer world-wide. In Poland, mortality from larynx cancer among males has been continuously increasing during the last decades up to 8.4 deaths per 100,000 men in 1993, which exceeds epidemiological records from other countries. The aetiology of laryngeal cancer is strongly associated with exposure to carcinogens present in tobacco smoke. The review describes a sequence of molecular and cellular events from carcinogenic exposure, DNA adduct formation, detection of mutations in the p53 gene, loss of heterozygosity (LOH) in chromosomal loci encoding the p53 and p16 genes, and loss of control of the cell cycle. The section concerning DNA adducts includes a discussion of the role of such confounders as exogenous exposure, the age and sex of the subject, and disease progression. The significance of genetic factors as individual risk determinants is discussed in relation to bleomycin-induced chromosome instability and in connection with ...
Identification of Integrin β1 as a Novel PAG1-Interacting Protein Involved in the Inherent Radioresistance of Human Laryngeal...Identification of Integrin β1 as a Novel PAG1-Interacting Protein Involved in the Inherent Radioresistance of Human Laryngeal...
1. Torre LA, Bray F, Siegel RL. et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87-108 2. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67:7-30 3. Chen W, Zheng R, Baade PD. et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115-32 4. Wong TS, Gao W, Li ZH. et al. Epigenetic dysregulation in laryngeal squamous cell carcinoma. J Oncol. 2012;2012:739461 5. Shimura T, Kakuda S, Ochiai Y. et al. Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys. 2011;80:540-8 6. Li Z, Yang X, Xia N. et al. PTOP and TRF1 help enhance the radio resistance in breast cancer cell. Cancer Cell Int. 2014;14:7 7. Zhou FX, Xiong J, Luo ZG. et al. cDNA expression analysis of a human radiosensitive-radioresistant cell line model identifies telomere function as a hallmark of radioresistance. Radiat Res. 2010;174:550-7 8. Kim JS, Chang ...
Hpv larynx cancer. Hpv related laryngeal cancer, Hpv virus and laryngeal cancer - natural-aloevera.roHpv larynx cancer. Hpv related laryngeal cancer, Hpv virus and laryngeal cancer - natural-aloevera.ro
Cu toate astea, n cele mai multe din cazuri infecia se remite de la A. It has been demonstrated that the human papil-loma-virus HPV type 16, a subtype of the human pa-pil-loma-virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive.
Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma<...Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma<...
TY - JOUR. T1 - Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. AU - Ljumanovic, R.. AU - Langendijk, J.A.. AU - Hoekstra, O.S.. AU - Knol, D.L.. AU - Leemans, C.R.. AU - Castelijns, J.A.. PY - 2008. Y1 - 2008. U2 - 10.1007/s00330-008-0986-x. DO - 10.1007/s00330-008-0986-x. M3 - Article. C2 - 18491097. VL - 18. SP - 2231. EP - 2240. JO - European Radiology. JF - European Radiology. SN - 0938-7994. IS - 10. ER - ...
Clinical, Histological and Immunohistochemical Evaluation of Larynx CancerClinical, Histological and Immunohistochemical Evaluation of Larynx Cancer
Laryngeal cancer represents the malignant degeneration, of epithelial nature or from the connective tissue, which starts in the constitutive elements of the larynx. Cancer localization in the larynx represents between 1% and 3% of all malignant tumors and approximately 50% of ear, nose and throat (ENT) tumors. Squamous cell carcinoma is the most common form (around 95%) of laryngeal cancer, with high incidence in human males from southern and central Europe, Romania occupying one of the top places. Material and Methods. Our study consisted of 490 patients diagnosed with laryngeal cancer from 2010 to 2016. They have been clinically, histologically, immunohistochemically, genetically, therapeutically and prognostically analyzed. Suspended microlaringoscopy has been the standard, allowing tumor extension evaluation and biopsy. All specimens were microscopically analyzed in standard or special histology stainings. For unclear histology specimens, immunohistochemical stainings were performed. Results and
Stage I Larynx Cancer | Texas OncologyStage I Larynx Cancer | Texas Oncology
Stage I larynx cancer can be treated with surgery or radiation therapy. When radiation therapy is used, surgery is reserved for cancer recurrence.
Computed tomography-based tumour volume as a predictor of outcome in laryngeal cancer: Results of the phase 3 ARCON trial.Computed tomography-based tumour volume as a predictor of outcome in laryngeal cancer: Results of the phase 3 ARCON trial.
PURPOSE: Retrospective studies indicate that larger tumour volume is a strong prognostic indicator for poor tumour control after (chemo)radiotherapy for laryngeal cancer. The impact of tumour volume on the outcome of patients treated within a prospective study comparing accelerated radiotherapy (AR)+/-carbogen breathing and nicotinamide (ARCON) was investigated. METHODS AND MATERIALS: Of 345 patients with cT2-4 laryngeal cancer, pre-treatment computed tomography (CT) scans of 270 patients were available for tumour volume calculation. Contouring of the primary tumour and involved lymph nodes was reviewed by one experienced head and neck radiation oncologist. Kaplan-Meier plots were used for analysis of outcome. RESULTS: Of 137 AR and 133 ARCON patients, 57 and 80 versus 56 and 77 patients had glottic and supraglottic tumours, respectively. A correlation between primary tumour volume and T-stage was observed (Rs=.51, P,.01). In both treatment arms no correlation was detected between the primary ...
Radiotherapy for laryngeal (larynx) cancer - Macmillan Cancer SupportRadiotherapy for laryngeal (larynx) cancer - Macmillan Cancer Support
Radiotherapy uses high-energy rays to destroy laryngeal cancer cells. It can be given on its own or with other cancer treatments.
NHS websiteNHS website
Alcohol and tobacco are the 2 main things that can increase your risk of developing laryngeal cancer. Theyre thought to contain chemicals that can damage the cells of the larynx.. The more you drink or smoke, the higher your risk of developing laryngeal cancer.. People who smoke more than 25 cigarettes a day, or people who have smoked for more than 40 years, have been found to be about 40 times more likely to develop laryngeal cancer than people who dont smoke.. Compared to people who dont drink, people who regularly drink large amounts of alcohol are about 3 times more likely to develop laryngeal cancer.. If you drink and smoke, your risk of laryngeal cancer increases even further. By stopping both drinking and smoking, you can significantly reduce your risk of developing the condition. Read more about preventing laryngeal cancer.. ...
What is laryngeal cancer? - Canadian Cancer SocietyWhat is laryngeal cancer? - Canadian Cancer Society
Laryngeal cancer starts in the cells that line the larynx. Learn about symptoms, diagnosis, treatment and risks in our guide to laryngeal cancer.
Laryngeal cancer: what signs accompany all stages of the disease? - Disease - 2020Laryngeal cancer: what signs accompany all stages of the disease? - Disease - 2020
Laryngeal cancer: what signs accompany all stages of the disease? Laryngeal cancer is a disease characterized by the formation of malignant cells in the tissues that are
Docetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA) - Full Text View - ClinicalTrials.govDocetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA) - Full Text View - ClinicalTrials.gov
The DeLOS II trial is a multicenter randomised phase II trial investigating a TP/5-Fluorouracil (TPF)-chemotherapy with or without cetuximab for Patients with only by laryngectomy operable carcinoma of the larynx/hypopharynx. Patients were divided in responder or non-responder after 4 weeks. Since August 2009 Responder receive TP with or without Cetuximab + radiation. (Until february 2009 Responder received TPF with or without Cetuximab + radiation.) Planned accrual is 85 patients per treatment arm. The primary study endpoint is a confirmatory proof of an adequate survival rate with a functionally larynx-conserving 2 years after randomisation ...
Docetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA) - Full Text View - ClinicalTrials.govDocetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA) - Full Text View - ClinicalTrials.gov
The DeLOS II trial is a multicenter randomised phase II trial investigating a TP/5-Fluorouracil (TPF)-chemotherapy with or without cetuximab for Patients with only by laryngectomy operable carcinoma of the larynx/hypopharynx. Patients were divided in responder or non-responder after 4 weeks. Since August 2009 Responder receive TP with or without Cetuximab + radiation. (Until february 2009 Responder received TPF with or without Cetuximab + radiation.) Planned accrual is 85 patients per treatment arm. The primary study endpoint is a confirmatory proof of an adequate survival rate with a functionally larynx-conserving 2 years after randomisation ...
Risk of Fatal Cerebrovascular Accidents After External Beam Radiotherapy for Early Stage Glottic Larynx Cancer | OncoLinkRisk of Fatal Cerebrovascular Accidents After External Beam Radiotherapy for Early Stage Glottic Larynx Cancer | OncoLink
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
HealthDay - Laryngeal Cancer NewsHealthDay - Laryngeal Cancer News
Laryngeal cancer, which typically forms in the squamous cells that line the inside of the larynx, makes up about 2 to 5 percent of diagnosed cases of cancer every year. It is about twice as common in men as it is in women, and it usually occurs in people older than 50.
Laryngeal Cancer | Radiotherapy Treatment. Hospital Prices, Ranking, Reviews - BookinghealthLaryngeal Cancer | Radiotherapy Treatment. Hospital Prices, Ranking, Reviews - Bookinghealth
➤Treatment of laryngeal cancer with radiotherapy ★ Direct prices from the best hospitals in the world $ We will help you save money on treatment ✔ Patient support 24/7
Treatment of laryngeal cancer with chemotherapy 1 course: Costs for treatment #250581 in Germany | BookingHealthTreatment of laryngeal cancer with chemotherapy 1 course: Costs for treatment #250581 in Germany | BookingHealth
Treatment of laryngeal cancer with chemotherapy 1 course (costs for program #250581) ✔ University Hospital Halle (Saale) ✔ Department of Hematology and Oncology (Department of Internal Medicine IV) ✔ BookingHealth.com
Durable complete regression of laryngeal cancer with pre-epiglottic space invasion after radiochemotherapy and the incidental...Durable complete regression of laryngeal cancer with pre-epiglottic space invasion after radiochemotherapy and the incidental...
Durable complete regression of laryngeal cancer with pre-epiglottic space invasion after radiochemotherapy and the incidental use of ACE-inhibitor: case report
Laryngeal Cancer | TriStar CentennialLaryngeal Cancer | TriStar Centennial
Learn more about Laryngeal Cancer at TriStar Centennial DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
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The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell CarcinomaThe Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma
Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis<...Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis<...
Laryngeal cancer: what signs accompany all stages of the disease? - Disease - 2020Laryngeal cancer: what signs accompany all stages of the disease? - Disease - 2020
Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer by E Ward, B Paigen et al.Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer" by E Ward, B Paigen et al.
Laryngeal Cancer | Radiotherapy Treatment. Hospital Prices, Ranking, Reviews - BookinghealthLaryngeal Cancer | Radiotherapy Treatment. Hospital Prices, Ranking, Reviews - Bookinghealth
MGMT promoter hypermethylation as a prognostic factor in patients with laryngeal squamous cell carcinoma | OncologyPROMGMT promoter hypermethylation as a prognostic factor in patients with laryngeal squamous cell carcinoma | OncologyPRO
Durable complete regression of laryngeal cancer with pre-epiglottic space invasion after radiochemotherapy and the incidental...Durable complete regression of laryngeal cancer with pre-epiglottic space invasion after radiochemotherapy and the incidental...
Laryngeal Neoplasms | Profiles RNSLaryngeal Neoplasms | Profiles RNS
Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer - Full Text View -...Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer - Full Text View -...
Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal...Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal...
Is human papillomavirus involved in laryngeal neuroendocrine carcinoma? - Research database - University of GroningenIs human papillomavirus involved in laryngeal neuroendocrine carcinoma? - Research database - University of Groningen
Vitamin B1 metabolism in laryngeal neoplasmsVitamin B1 metabolism in laryngeal neoplasms
Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancerReevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer
Advanced computing solutions for analysis of laryngeal disorders.Advanced computing solutions for analysis of laryngeal disorders.
Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancerInduction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer
ICD-10-CM Code C32.3 - Malignant neoplasm of laryngeal cartilageICD-10-CM Code C32.3 - Malignant neoplasm of laryngeal cartilage
Laryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 CasesLaryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 Cases
Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and...The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and...
Role of Advanced Laryngeal Imaging in Glottic Cancer: Early Detection and Evaluation of Glottic Neoplasms<...Role of Advanced Laryngeal Imaging in Glottic Cancer: Early Detection and Evaluation of Glottic Neoplasms<...
Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review.Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review.
Primary laryngeal lymphoma: report of 3 cases and review of the literature.Primary laryngeal lymphoma: report of 3 cases and review of the literature.
Laryngeal edema | definition of laryngeal edema by Medical dictionaryLaryngeal edema | definition of laryngeal edema by Medical dictionary
Laryngeal Diseases Summary Report | CureHunterLaryngeal Diseases Summary Report | CureHunter
Laryngeal | definition of laryngeal by Medical dictionaryLaryngeal | definition of laryngeal by Medical dictionary
Throat Cancer | Throat Cancer Symptoms | MedlinePlusThroat Cancer | Throat Cancer Symptoms | MedlinePlus
Pembrolizumab in Combination With CRT for LA-SCCHN - Full Text View - ClinicalTrials.govPembrolizumab in Combination With CRT for LA-SCCHN - Full Text View - ClinicalTrials.gov
F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients - Tabular View -...F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients - Tabular View -...
Laryngeal carcinoma and professional exposure: critical review of the literatur - Otorinolaringologia 2019 June;69(2):91-106 -...Laryngeal carcinoma and professional exposure: critical review of the literatur - Otorinolaringologia 2019 June;69(2):91-106 -...
Laringectomía total ampliada en carcinoma laríngeo avanzado T4aLaringectomía total ampliada en carcinoma laríngeo avanzado T4a
Malignant fibrous histiocytoma of the larynx after radiotherapy for squamous cell carcinoma | SpringerLinkMalignant fibrous histiocytoma of the larynx after radiotherapy for squamous cell carcinoma | SpringerLink
Voice Center Research Labs - Massachusetts General Hospital, Boston, MAVoice Center Research Labs - Massachusetts General Hospital, Boston, MA
2018 ICD-10-CM Diagnosis Code C49: Malignant neoplasm of other connective and soft tissue2018 ICD-10-CM Diagnosis Code C49: Malignant neoplasm of other connective and soft tissue
Uncommon Metastasis of Laryngeal Cancer to Small Bowel Causing Intestinal Obstruction Treated by Laparoscopic ApproachUncommon Metastasis of Laryngeal Cancer to Small Bowel Causing Intestinal Obstruction Treated by Laparoscopic Approach
Chronic LaryngitisChronic Laryngitis
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Laryngeal NeoplasmsCarcinoma, Squamous CellLarynxVocal CordsVocal Cord ParalysisLaryngectomyHead and Neck NeoplasmsGastroesophageal RefluxGlottisEsophageal pH MonitoringFundoplicationEsophagusEsophagitisCarcinoma, NeuroendocrinePeriodicals as TopicAccess to InformationJournal Impact FactorBibliometricsPublishingPeer Review, ResearchDideoxynucleosidesInfusions, Intra-ArterialTreatment OutcomeFluorine RadioisotopesPositron-Emission TomographyAntineoplastic Combined Chemotherapy ProtocolsLarynx, ArtificialOrgan Sparing TreatmentsSpeech, AlaryngealSpeech, EsophagealChileArchivesBiological Science DisciplinesPubMedDirectories as TopicDeath, SuddenAutopsyBereavementCoroners and Medical ExaminersForensic PathologyCause of DeathTerminology as TopicLiterature, ModernConnecticutNasal CavitySalivary GlandsThyroid GlandRadiotherapy, Intensity-ModulatedOtolaryngologyCellular PhoneWisconsinMiddle Ear VentilationOtitis Media with EffusionProfessional Practice LocationHearing Loss, Conductive
SquamousLarynxPatientsTumorDiseaseLungSearchStageCancerRecurrenceLesionsMetastasisPapillomatosisSquamous cellPharyngealEpithelialVOCAL CORDSEtiologyCarcinoma in SCartilage2017GlotticDiseasesAbstractMetastaticIdentification of laryngealNeckClinicalNeoplasticBiopsyCase of laryngeal
Squamous1
Larynx3
Patients7
  • BACKGROUND The objectives of this study were to identify factors associated with treatment differences, characterize changes in treatment patterns over time, and compare survival across treatment types in patients who received treatment for localized laryngeal cancer. (umn.edu)
  • METHODS Using the Surveillance, Epidemiology, and End Results database, we conducted a retrospective cohort analysis of patients who were treated from 1995 to 2009 for localized laryngeal cancer. (umn.edu)
  • RESULTS In total, 10,429 patients with localized laryngeal cancer were identified. (umn.edu)
  • CONCLUSIONS Although treatment patterns became more adherent to treatment guidelines over time, we identified survival differences associated with treatment type that warrant further investigation into treatment decision-making for patients with localized laryngeal cancer. (umn.edu)
  • To test whether the distribution of AHH inducibility is shifted toward the high end of the range in patients who had lung and laryngeal cancer, we measured this trait in 59 patients (32 lung and 27 laryngeal) who had resectable tumors and had been disease-free for a period of time. (jax.org)
  • in patients who had laryngeal cancer 2.96 +/- 0.18, and for all controls 3.29 +/- 0.04 (no significant difference at p = 0 05). (jax.org)
  • Further analysis of the distribution of AHH inducibility in the patient group compared to controls showed no suggestion of a shift toward the higher end of the range in patients who had lung and laryngeal cancer. (jax.org)
Tumor1
  • Laryngeal cancer stage 4 can be determined by the presence of a sufficiently extensive tumor, which occupies a relatively large area of ​​the organ with tissue infiltration. (velaiat.com)
Disease1
Lung2
Search1
Stage1
Cancer85
Recurrence1
Lesions11
Metastasis2
Papillomatosis3
Squamous cell8
Pharyngeal3
Epithelial1
  • Laryngeal neuroendocrine carcinomas (LNECs) are rare but are the most common nonsquamous tumors of this organ, which can be divided into 2 broad categories based on their tissue of origin: epithelial and neural. (hindawi.com)
VOCAL CORDS1
Etiology1
Carcinoma in S2
Cartilage1
  • Two imaging findings were considered as neoplastic invasion of the laryngeal cartilage-increased density and chondrolysis. (sid.ir)
20171
  • EVIDENCE ACQUISITION: A careful analysis of the Literature regarding the possible etiological role of the professional activity in laryngeal neoplasia has been carried out, focusing mainly on the years 1990-2017. (minervamedica.it)
Glottic3
Diseases1
Abstract1
Metastatic2
Identification of laryngeal2
  • art methods and reveals open issues and problems of computing solutions for analysis and identification of laryngeal disorders. (bioportfolio.com)
  • Early identification of laryngeal neoplasms results in improved prognosis and functional outcomes. (elsevier.com)
Neck1
  • Recurrent laryngeal nerve stimulation is delivered by applying electric charge from an electrode in the form of a probe or an indwelling device to the intact neck skin at specific points. (google.com)
Clinical1
  • In conclusion, a laryngeal granuloma was detected in a racing thoroughbred mare by a multidisciplinary, clinical study involving endoscopy , as well as histopathologic and microbiologic studies. (bvsalud.org)
Neoplastic1
  • This study was conducted to determine the diagnostic accuracy of computed tomography (CT) to detect the neoplastic invasion of the laryngeal cartilages. (sid.ir)
Biopsy1
Case of laryngeal1
  • To the best of our knowledge, this is only the second case of laryngeal lipoma associated with lipomatosis to be reported in the English-language literature. (biomedsearch.com)
Throat Cancer | Throat Cancer Symptoms | MedlinePlus
Throat Cancer | Throat Cancer Symptoms | MedlinePlus (medlineplus.gov)
Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer - Full Text View -...
Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer - Full Text View -... (clinicaltrials.gov)
Is human papillomavirus involved in laryngeal neuroendocrine carcinoma? - Research database - University of Groningen
Is human papillomavirus involved in laryngeal neuroendocrine carcinoma? - Research database - University of Groningen (rug.nl)
Malignant fibrous histiocytoma of the larynx after radiotherapy for squamous cell carcinoma | SpringerLink
Malignant fibrous histiocytoma of the larynx after radiotherapy for squamous cell carcinoma | SpringerLink (link.springer.com)
Voice Center Research Labs - Massachusetts General Hospital, Boston, MA
Voice Center Research Labs - Massachusetts General Hospital, Boston, MA (massgeneral.org)
Pathology of Sudden Natural Death: Overview, Terminology, Medical Examiner Role and Autopsy Indications
Pathology of Sudden Natural Death: Overview, Terminology, Medical Examiner Role and Autopsy Indications (emedicine.medscape.com)
Salivary Gland Neoplasms: Practice Essentials, Etiology, Pathophysiology
Salivary Gland Neoplasms: Practice Essentials, Etiology, Pathophysiology (emedicine.medscape.com)
Dr. Charles N Ford Jr, MD | Madison, WI | Otolaryngologist
Dr. Charles N Ford Jr, MD | Madison, WI | Otolaryngologist (vitals.com)
Head and Neck Cancer | Cancer Network
Head and Neck Cancer | Cancer Network (cancernetwork.com)
Zyrtec Malaise Side Effects
Zyrtec Malaise Side Effects (patientsville.com)
Voice & Swallowing Conditions We Treat | Mount Sinai - New York
Voice & Swallowing Conditions We Treat | Mount Sinai - New York (mountsinai.org)
Cancer Biomarkers - Volume 25, issue 2 - Journals - IOS Press
Cancer Biomarkers - Volume 25, issue 2 - Journals - IOS Press (content.iospress.com)
Advanced computing solutions for analysis of laryngeal disorders.
Advanced computing solutions for analysis of laryngeal disorders. (bioportfolio.com)
Laryngeal carcinoma and professional exposure: critical review of the literatur - Otorinolaringologia 2019 June;69(2):91-106 -...
Laryngeal carcinoma and professional exposure: critical review of the literatur - Otorinolaringologia 2019 June;69(2):91-106 -... (minervamedica.it)
Effect of 5-zaz on MYCT1 expression in Hep-2 cells. A. | Open-i
Effect of 5-zaz on MYCT1 expression in Hep-2 cells. A. | Open-i (openi.nlm.nih.gov)
Edward J. Damrose, MD, FACS | Stanford Medicine Profiles
Edward J. Damrose, MD, FACS | Stanford Medicine Profiles (med.stanford.edu)