Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas. (1/1167)
Laryngeal papillomas are benign tumors caused by human papillomaviruses types 6 and 11. This study addressed alterations in levels of signal transduction from the epidermal growth factor receptor (EGFR) in papillomas and cultured papilloma cells compared to normal tissue and cells. Mitogen-activated protein kinase (MAPK) was activated to a greater extent, phosphotyrosine was more abundant, and EGFR was overexpressed in laryngeal papillomas compared to normal laryngeal epithelium by Western blot analysis. The EGFR was 3 times more abundant in cultured papilloma cells than in normal laryngeal cells by Scatchard analysis and Western blot, without gene amplification or an increase in steady-state levels of mRNA. Following stimulation with EGF, a significant portion of the EGFR was recycled to the surface in papilloma cells, whereas in normal cells, it was not. Tyrosine kinase activity and activation of MAPK was more responsive to epidermal growth factor stimulation in papilloma cells than in uninfected primary laryngeal cells. PD153035, a specific inhibitor of the EGFR, and an EGFR-specific antibody that blocks ligand binding completely abrogated basal MAPK activation by endogenous ligands in laryngeal papilloma cells. These results demonstrated that infection of laryngeal epithelium by low-risk human papillomaviruses elevates the EGFR by posttranslational mechanisms, increasing its responsiveness to ligand-mediated activation. They also showed that MAPK activation in laryngeal papillomas depends upon ligand-mediated EGFR stimulation. (+info)Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. (2/1167)
Glutathione S-transferases (GSTs) are involved in detoxification of reactive metabolites of carcinogens and, therefore, could be potentially important in susceptibility to cancer. The associations between larynx cancer risk and GSTM3 and GSTP1 gene polymorphisms, either separately or in combination with GSTM1 and GSTT1 gene polymorphisms, were evaluated using peripheral blood DNA from 129 cancer patients and 172 controls, all regular smokers. The frequencies of GSTM3 AA, AB, and BB genotypes were 60.5%, 36.4%, and 3.1% in cases and 72.7%, 24.4%, and 2.9% in controls, respectively. The frequencies of GSTP1 AA, AG, and GG genotypes were 48.1%, 40.3%, and 11.6% in cases and 50.0%, 37.2%, and 12.8% in controls, respectively. Multivariate logistic regression analyses did not reveal any association between the GSTP1 (AG or GG) genotype and larynx cancer [odds ratio, 1.1; 95% confidence interval (CI), 0.7-2.0]. In contrast, a significant increase in risk was related to the GSTM3 (AB or BB) genotype (odds ratio, 2.0; 95% CI, 1.1-3.4). The combined GSTM3 (AB or BB) and GSTM1-null genotype conferred a 4-fold risk (95% CI, 1.6-10.1) of larynx cancer as compared with the combined GSTM3 AA and GSTM1-positive genotype. However, the effect of GSTM3 (AB or BB) genotype was similar among individuals with GSTM1-positive or GSTM1-null genotypes. (+info)Concordant induction of cyclin E and p21cip1 in differentiated keratinocytes by the human papillomavirus E7 protein inhibits cellular and viral DNA synthesis. (3/1167)
Productive infections by human papillomaviruses (HPVs) occur only in differentiated keratinocytes in squamous epithelia in which the HPV E7 protein reactivates the host DNA replication machinery to support viral DNA replication. In a fraction of the differentiated keratinocytes, E7 also posttranscriptionally induces p21Cip1, which is distributed in a mutually exclusive manner with unscheduled cellular DNA synthesis. In this study, double immunofluorescence labeling unexpectedly revealed that E7 caused a concordant accumulation of both cyclin E and p21Cip1 to high levels in patient papillomas and in organotypic cultures of primary human keratinocytes. The induction of cyclin E is mutually exclusive with unscheduled cellular DNA synthesis or abundant viral DNA. These novel virus-host interactions in differentiated keratinocytes are in contrast to previous observations made in submerged proliferating cultures, in which HPV E7 induces cyclin E and overcomes p21Cip1 inhibition of S-phase entry. We propose that an appropriately timed induction of cyclin E/cyclin-dependent kinase 2 by HPV E7 in postmitotic cells enables S-phase reentry and HPV DNA amplification, whereas prematurely induced cyclin E stabilizes p21Cip1 protein, which then inhibits cyclin E/cyclin-dependent kinase 2. Consequently, cyclin E and p21Cip1 both fail to turn over, and DNA synthesis does not occur. (+info)Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. (4/1167)
PURPOSE: To determine the utility of pretreatment computed tomography (CT) for predicting primary site control in patients with supraglottic squamous cell carcinoma (SCC) treated with definitive radiotherapy (RT). MATERIALS AND METHODS: Pretreatment CT studies in 63 patients were reviewed. Minimum length of follow-up was 2 years. Local recurrence and treatment complications resulting in permanent loss of laryngeal function were documented. Tumor volume was calculated using a computer digitizer, and pre-epiglottic space (PES) spread was estimated. The data were analyzed using a combination of Fisher's exact test, logistic regression modeling, and multivariate analyses. Five-year local control rates were calculated using the product-limit method. RESULTS: Local control rates were inversely and roughly linearly related to tumor volume, although there seemed to be a threshold volume at which primary site prognosis diminished. Local control was 89% in tumors less than 6 cm3 and 52% when volumes were > or =6 cm3 (P = .0012). The likelihood of maintaining laryngeal function also varied with tumor volume: 89% for tumors less than 6 cm3 and 40% for tumors > or =6 cm3 (P = .00004). Pre-epiglottic space involvement by tumor of > or =25% was associated with a reduced chance of saving the larynx (P = .0076). Multivariate analyses revealed that only tumor volume independently altered these end points. CONCLUSION: Pretreatment CT measurements of tumor volume permits stratification of patients with supraglottic SCC treated with RT alone (which allows preservation of laryngeal function) into groups in which local control is more likely and less likely. Pre-epiglottic space spread is not a contraindication to using RT as the primary treatment for supraglottic SCC. (+info)Sternothoracotomy for combined coronary artery bypass grafting and left upper lobectomy in a patient with low-lying tracheostoma. (5/1167)
A 64-year-old man had a low-lying tracheostoma and presented with unstable angina and a mass in the pulmonary left upper lobe. Simultaneous coronary revascularization and resection of the lung neoplasm were completed through a sternothoracotomy (clam-shell) incision. The advantages of this approach include excellent exposure to the mediastinum and the lung fields, and the option of using both internal thoracic arteries for bypass grafting. (+info)Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (6/1167)
Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction. (+info)The difference between delayed extubation and tracheostomy in post-operative sleep apnea after glossectomy or laryngectomy. (7/1167)
BACKGROUND: Patients with cancer of the tongue or larynx require glossectomies or laryngectomies and subsequent reconstruction. These procedures remove part of the patient's upper airway. In cancer of the tongue, the removed part of the airway is substituted by a flap of their skin. Post-operatively, it is possible that the patients have problems respiring comfortably. In addition to this, long surgical procedures may simply interfere with their circadian rhythm. To elucidate the possible change in their post-operative respiration, we monitored the patient's respiratory pattern with an apnea monitor. METHODS: We attached an apnea monitor to the patients and recorded their respiratory pattern and arterial oxygen saturation. The patients were monitored for a total of five days: three days prior to the operation, one day before the operation, the day of operation, two days after, and on the fourth day after the operation. The period of monitoring was from 8:00 p.m. to 6:00 a.m. the next morning. RESULTS: Sixteen patients completed this study. The patients whose tube was extubated after glossectomy showed frequent apnea, low mean oxygen saturation and low comfort score as compared to the patients with tracheostomy after laryngectomy. Because two failed cases of free skin flap were among the former, it is possible that the frequent apnea is a factor of failed free skin graft after glossectomy and laryngectomy. CONCLUSION: Further studies are required to improve the patient's respiration during their sleep after tracheal extubation in glossectomy. (+info)Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase. (8/1167)
The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]]. The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine). Here, we have determined the protective effect of overexpression of allelic variants of hGSTP1-1, through stable transfection in HepG2 cells, against (+)-anti-BPDE-induced DNA modification. Clonal transfectants of HepG2 cells corresponding to the three allelic variants of hGSTP1-1 [(I104,A113), (V104,A113), and (V104,V113), denoted hGSTP1(IA), hGSTP1(VA), and hGSTP1(VV), respectively] with similar levels of hGSTP1 protein were identified and characterized for their GST activity and (+)-anti-BPDE-induced DNA modification. The glutathione S-transferase activity toward (+)-anti-BPDE was significantly higher (approximately 3.0-3.6-fold) in cells transfected with hGSTP1(VA) [HepG2(VA)] and hGSTP1(VV) [HepG2(VV)] compared with hGSTP1(IA) transfectant [HepG2(IA)]. The formation of (+)-anti-BPDE-DNA adducts was significantly reduced in HepG2(VA) and HepG2(VV) cells compared with cells transfected with insert-free vector (HepG2-vect). Maximum protection against (+)-anti-BPDE-induced DNA damage was afforded by the hGSTP1(VV) isoform. The results of this study indicate that the allelic variants of hGSTP1-1 significantly differ in their ability to provide protection against (+)-anti-BPDE-induced DNA damage. Thus, hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to tumorigenesis induced by benzo[a]pyrene. (+info)The most common types of laryngeal neoplasms include:
1. Vocal cord nodules and polyps: These are benign growths that develop on the vocal cords due to overuse, misuse, or trauma.
2. Laryngeal papillomatosis: This is a condition where warts grow on the vocal cords, often caused by the human papillomavirus (HPV).
3. Adenoid cystic carcinoma: This is a rare type of cancer that develops in the salivary glands near the larynx.
4. Squamous cell carcinoma: This is the most common type of cancer that develops in the larynx, often due to smoking or heavy alcohol consumption.
5. Verrucous carcinoma: This is a rare type of cancer that develops on the vocal cords and is often associated with chronic inflammation.
6. Lymphoma: This is a type of cancer that affects the immune system, and can develop in the larynx.
7. Melanoma: This is a rare type of cancer that develops from pigment-producing cells called melanocytes.
Symptoms of laryngeal neoplasms can include hoarseness or difficulty speaking, breathing difficulties, and ear pain. Diagnosis is typically made through a combination of physical examination, imaging tests such as CT scans or MRI, and biopsy. Treatment options vary depending on the type and severity of the neoplasm, but may include surgery, radiation therapy, or chemotherapy.
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Browsing by Subject "Laryngeal Neoplasms"
Laryngeal Neoplasms - MeSH - NCBI
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papillomavirus infections[majr:noexp] AND (genital warts[mh] OR laryngeal neoplasms[mh] OR epidermodysplasia verruciformis[mh])...
Neuroendocrine laryngeal neoplasm. A report of two cases - Otorinolaringologia 2001 December;51(4):155-8 - Minerva Medica -...
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Carcinoma16
- Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response? (umassmed.edu)
- Notch1 and Ki-67 expression in laryngeal squamous cell carcinoma (LSCC) tissue samples were detected by immunohistochemistry. (researchsquare.com)
- Our study has demonstrated that hypoxia may promote cell proliferation and inhibit cell apoptosis of laryngeal carcinoma. (researchsquare.com)
- Laryngeal carcinoma has been considered as a common malignancy of the head and neck. (researchsquare.com)
- 9 ], our previous data has observed that the expression level of Notch1 in laryngeal cancer tissues is significantly higher than that in normal mucosal tissues, and was positively associated with lymph node metastasis and clinical stage [ 10 ], suggesting that aberrant Notch1 signaling may be involved in regulating the malignant process of laryngeal carcinoma. (researchsquare.com)
- As mentioned above, the role of Notch1 signaling in regulating cellular proliferation and apoptosis of laryngeal carcinoma by in vitro studies with Hep-2 cells is also controversial. (researchsquare.com)
- Chemoradiation for patients with laryngeal squamous cell carcinoma (SCC) may achieve organ preservation, but appropriate patient selection remains unknown. (nih.gov)
- Merkel cell carcinoma (MCC) is a rare, rapidly growing, and aggressive dermatological neoplasm. (deepdyve.com)
- Laryngeal papilloma carcinoma. (malaimare.ro)
- Indicatii si Tehnici operatorii: Cordectomia se adreseaza cancerului treimii medii a corzii vocale T1,T2cu mobilitate pastrata a acesteia, leziunilor displazice ale corzilor laryngeal papilloma carcinoma si carcinomului in situ. (malaimare.ro)
- Laryngeal tumor suspicion can be raised in the early laryngeal papilloma carcinoma by dysphonia, not accompanied by pain. (malaimare.ro)
- Cordectomy can be done endoscopically, by transoral approach and laryngeal papilloma carcinoma open surgery through laringofissure. (malaimare.ro)
- Patologie tumorala este o problema de sanatate publica laryngeal papilloma carcinoma continua crestere, unul dintre principalele scopuri ale lumii medicale fiind dezvoltarea metodelor de screening si detectie precoce, in stadii cat mai tratabile, a neoplaziilor. (malaimare.ro)
- Simptomul de alarma, usor de remarcat de catre pacient si laryngeal papilloma carcinoma util descoperirii tumorii laringiene in bacterii filamentoase incipiente este disfonia, neinsotita de durere. (malaimare.ro)
- Laryngeal papilloma carcinoma factori de risc citati sunt Human Papilloma Virus HPV - mai ales HPV 16, refluxul gastro-esofagian, expunerea la rumegus, laryngeal papilloma carcinoma, radiatii ionizante si diversi compusi chimici volatili, imunosupresia si susceptibilitatea genetica. (malaimare.ro)
- Paraliziile laryngeal papilloma carcinoma sunt datorate lezarii nervului laringeu recurent, fie iatrogen chirurgical, in timpul manevrelor de intubatie oro trahealafie printr-un proces tumoral laryngeal papilloma carcinoma, tiroidian sau de mediastin superior. (malaimare.ro)
Larynx2
Malignant3
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
- Categories D37 - D44 , and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. (icd10data.com)
Cancer17
- What's New in Laryngeal and Hypopharyngeal Cancer Research and Treatment? (medlineplus.gov)
- 10. Organ preservation surgery for laryngeal cancer. (nih.gov)
- 13. Does vocal cord fixation preclude nonsurgical management of laryngeal cancer? (nih.gov)
- 14. [A laryngeal cancer in pregnancy]. (nih.gov)
- 16. Looking at laryngeal cancer. (nih.gov)
- 17. Pathological validation of supracricoid partial laryngectomy in laryngeal cancer. (nih.gov)
- Niscola, P. (2013) "Complex and Multifaceted Therapy-Related Myeloid Neoplasm Following Laryngeal Cancer Treated with Cisplatin and Radiotherapy", Mediterranean Journal of Hematology and Infectious Diseases , 5(1), p. e2013030. (mjhid.org)
- Occupational risk for laryngeal cancer. (nih.gov)
- In a case-control analysis, we studied the effects of type of employment on laryngeal cancer risk using the interview data from the Third National Cancer Survey. (nih.gov)
- The study aims to identify the effects of Notch1 signaling on the proliferation and apoptosis of laryngeal cancer cells in hypoxic microenvironment. (researchsquare.com)
- In laryngeal cancer cells, small interfering RNA (siRNA) technology was to inhibit Notch1 expression. (researchsquare.com)
- Notch1 signalling may exert a pivotal role in regulating the proliferation and apoptosis resistance of laryngeal cancer cells under hypoxia. (researchsquare.com)
- To date, the regulatory mechanism of the aberrant growth of laryngeal cancer cells has not been elucidated. (researchsquare.com)
- Unfortunately, the regulatory effect and mechanisms of hypoxia on the proliferation and apoptosis of laryngeal cancer cells are still unclear. (researchsquare.com)
- Accordingly, the purpose of current research was to further explore the effects of Notch1 signaling on the regulation of apoptosis and proliferation of laryngeal cancer cells in the hypoxic microenvironment, clarifying the regulatory role of Notch1 signaling in tumor progression. (researchsquare.com)
- Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy. (ucdenver.edu)
- Treatment outcomes and cost comparisons for older adults with T4 laryngeal squamous cell cancer. (ucdenver.edu)
Neuroendocrine1
- Neuroendocrine laryngeal neoplasm. (minervamedica.it)
Obstruction1
- Postextubation airway obstruction from occult laryngeal mass. (umassmed.edu)
Malignancy1
- Laryngeal candidiasis mimicking malignancy. (umassmed.edu)
Benign1
- Recurrent respiratory papillomatosis (RRP) is the most common benign pediatric laryngeal neoplasm. (deepdyve.com)
Tumors1
- For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icd10data.com)
MeSH1
- Laryngeal Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Risk Factors1
- This study investigates pre-treatment risk factors associated with functional and survival outcomes after radiation-based therapy in patients with advanced laryngeal SCC. (nih.gov)
Outcomes1
- Baseline laryngeal functional status and overall health in advanced laryngeal SCC are associated with poor functional outcomes after radiation-based therapy, highlighting the importance of patient selection when deciding between surgical and non-surgical treatment plans. (nih.gov)
Functional1
- An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm. (icd10data.com)
Definitive1
- A retrospective cohort study was performed on 75 adult patients with stage III or IV laryngeal SCC receiving definitive radiation-based therapy from 1997 to 2016 at a tertiary care center. (nih.gov)
Adult1
- 11. Laryngeal alveolar rhabdomyosarcoma involving the true vocal fold in an adult: Case report. (nih.gov)
Carcinoma1
- 8. [Surgical management and preservation of laryngeal function for senile patients with advanced laryngeal carcinoma]. (nih.gov)
Larynx1
- This article focuses on the use of CT imaging in the evaluation of the larynx, with particular focus on laryngeal neoplasia, trauma, foreign bodies, and radiation-induced changes. (medscape.com)
Squamous1
- INTRODUCTION: A multitude of treatment modalities have been proposed in management of early laryngeal squamous cell cancers(SCC). (bvsalud.org)
Laryngectomy1
- 9. [Horizontal laryngectomy in treatment of laryngeal cancer--oncologic and function results]. (nih.gov)
Cancers2
- Can Laryngeal and Hypopharyngeal Cancers Be Found Early? (medlineplus.gov)
- Can Laryngeal and Hypopharyngeal Cancers Be Prevented? (medlineplus.gov)
Lung1
- The aggregate data are reassuring in excluding any excess risk of death from lung, laryngeal, soft tissue sarcoma, brain and lymphoid neoplasms, as well as cirrhosis. (nih.gov)
Commonly2
- CT scanning has become the most commonly used technique for general laryngeal imaging. (medscape.com)
- Salivary gland neoplasms most commonly appear in the sixth decade of life. (medscape.com)
Study1
- A further study of laryngeal neoplasms in America. (nih.gov)
Cases1
- [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
Patients3
- The acquisition time for a CT image is extremely short (within a matter of seconds), which is quite useful for the laryngeal examination, as patients are generally required to hold their breath to reduce movement. (medscape.com)
- Contrasting information was derived through a literature review by Louredo et al, which indicated that in pediatric patients, most salivary gland neoplasms (75.4%) are malignant. (medscape.com)
- Salivary gland neoplasms occurred with slightly greater frequency in girls (57.4% of patients) than in boys. (medscape.com)
Results2
- Failure in the development of the TES, as seen in laryngeal and laryngoesophageal cleft, results in a communication between the 2 lumens and allows for aspiration of esophageal contents. (medscape.com)
- Failure of complete recanalization results in laryngeal or subglottic stenosis. (medscape.com)
Children2
- Salivary gland neoplasms are rare in children. (medscape.com)
- In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
True1
- the lumen recanalizes later by the 10th week of gestation and, in doing so, helps form the laryngeal ventricles and true and false vocal cords. (medscape.com)
Table1
- Some common salivary gland neoplasms are listed in the table below. (medscape.com)