A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Educational institutions.
Selection of a type of occupation or profession.
Individuals enrolled in a school or formal educational program.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Professionals qualified by graduation from an accredited school of nursing and by passage of a national licensing examination to practice nursing. They provide services to patients requiring assistance in recovering or maintaining their physical or mental health.
Individuals enrolled in a school of medicine or a formal educational program in medicine.
A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Substances which lower blood glucose levels.
Pathological processes involving the URETHRA.
Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.
A basidiomycetous fungal genus of the family Agaricaceae, order Agaricales, which includes the field mushroom (A. campestris) and the commercial mushroom (A. bisporus).
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Introduction of substances into the body using a needle and syringe.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Insulin formulations that contain substances that retard absorption thus extending the time period of action.
BIOLOGIC PRODUCTS that are imitations but not exact replicas of innovator products.
An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Glucose in blood.
Sequential operating programs and data which instruct the functioning of a digital computer.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.
Communication between CELL PHONE users via the Short Message Service protocol which allows the interchange of short written messages.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
"Lantus EPAR". European Medicines Agency (EMA). Retrieved 7 May 2020. EPAR Lantus Archived 2006-11-22 at the Wayback Machine, ... "Lantus 100 units/ml solution for injection in a cartridge - Summary of Product Characteristics (SmPC)". (emc). Retrieved 7 May ... In 2007, Lantus was the 15th highest selling pharmaceutical product in Germany.[citation needed] The investment in the ... Insulin glargine, marketed under the names Lantus among others, is a long-acting insulin, used in the management of type I and ...
The slow-release insulins (e.g., Lantus and Levemir) can provide a similar effect. In healthy individuals, basal rate is ...
The other type is long acting insulin; the first of these was Lantus (insulin glargine). These have a steady effect for an ...
Lantus (insulin glargine), for type 1 and type 2 diabetes mellitus. Skelid (Tiludronic acid), for Paget's disease of bone. ... Lantus (insulin glargine), for type 1 and type 2 diabetes mellitus. Soliqua (insulin glargine/lixisenatide), for type 2 ...
The most successful documented method is tight regulation with Lantus or Levemir. Typical obstacles to regulation include: ... Lantus). Studies have had good results with insulin glargine in cats. Follow-up research shows that Levemir can be used with a ... Lantus) and detemir (Levemir). The first goal is to regulate the cat's blood glucose by keeping the blood glucose values in a ...
2000 Sanofi Aventis Lantus insulin "glargine" analogue approved for clinical use in the US and Europe. 2004 Sanofi Aventis ...
Glucose Control - Lantus receives FDA approval for flexible administration Analog Insulin "Insulin Analogue Therapy for ... "Lantus insulin glargine (rDNA origin) injection". Retrieved 2007-06-08. Owens DR, Bolli GB. 2008 Beyond the era of NPH insulin ... and markets it under the trade name Lantus. It was created by modifying three amino acids. Two positively charged arginine ... Food and Drug Administration 2003 Aventis Lantus "glargine" insulin analogue approved in USA 2004 Sanofi Aventis Apidra insulin ...
He is the chairman of Sanofi, a French pharmaceutical firm, known for its prescription products such as Lantus insulin. Accor, ...
With Lantus and protamine zinc insulin (PZI) being unreliable in dogs, they are rarely used to treat canine diabetes. Bovine ...
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In April 2020, he took to Instagram to ask the public for help in locating insulin glargine, also known as Lantus, asking ...
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The company was started by Sheridan Snyder and George M. Whitesides in 1981.[3] Genzyme's scientific founder was Henry Blair who had a contract with the National Institutes of Health (NIH) to produce modified enzymes for the NIH to test in clinical trials.[4] Blair was a technician at the New England Enzyme Center at Tufts Medical School.[4] Genzyme's first office was an old clothing warehouse adjacent to Tufts Medical School.[4] In 1981,with the help of venture capital funding, the company made its first acquisition; Whatman Biochemicals Ltd. In 1982, it made its second acquisition, British-based Koch-Light Laboratories, later becoming Genzyme Pharmaceutical and Fine Chemicals.[5] Henri Termeer joined Genzyme as its president in 1983 and worked to redirect the company, which by this time had reached a valuation of $100 million, from its focus on diagnostic enzymes to modified enzymes for use as human therapeutics.[6] In 1984, Robin Berman, MD, who volunteered at the NIH, had a three-year-old ...
Lantus or Levemir) တို့ကို ပေါင်းစပ်ပြီး အသုံးပြုလေ့ရှိသည်။ ဆီးချို-၁ ဖြစ်သော ကလေးများတွင် အင်ဆူလင် အန်နာလော့ဂ် Analog များကို ...
Easy-to-read patient leaflet for Lantus. Includes indications, proper use, special instructions, precautions, and possible side ... How is this medicine (Lantus) best taken?. Use this medicine (Lantus) as ordered by your doctor. Read all information given to ... What do I need to tell my doctor BEFORE I take Lantus?. *If you have an allergy to insulin or any other part of this medicine ( ... What are some things I need to know or do while I take Lantus?. *Tell all of your health care providers that you take this ...
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... By WIR Staff. A pooled analysis of 2,171 Type II diabetics from 11 randomized clinical ...
2 How Should Lantus be Used?3 Who Should Take Lantus?4 Who Should Not Take Lantus?5 What Are the Side Effects of Lantus?6 What ... Lantus is manufactured by Sanofi-Aventis. Since the patent on Lantus expired in 2015, other biosimilar versions of insulin ... Lantus is the brand name for the synthetic insulin glargine, which is an injectable form of insulin designed to help people ... Medications Can Interact with Lantus? How Does Lantus Work? Insulin is the key that unlocks your cells, which allows the sugar ...
When Lillys new Bio-Similar insulin for Lantus becomes available for maybe 20% less, will you let your patients know? Follow ... When Lillys new Bio-Similar insulin for Lantus becomes available for maybe 20% less, will you let your patients know? ...
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Lantus has been available for pharmaceutical use since the year 2000. ... Lantus is an analogue insulin produced by Sanofi-Aventis with the medical name insulin glargine. ... What is Lantus? Lantus is an ultralente (long acting) analogue insulin The medical name for Lantus, insulin glargine, is taken ... Benefits of Lantus The mode of action of Lantus allows for a peakless profile. Lantus has become a popularly prescribed insulin ...
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  • Insulin glargine, marketed under the names Lantus among others, is a long-acting insulin, used in the management of type I and type II diabetes. (wikipedia.org)
  • citation needed] The investment in the production of Lantus and insulin pen manufacturing in Frankfurt-Höchst cost €700 million. (wikipedia.org)
  • Some studies have reported that long-term use of insulin glargine ( Lantus ) is associated with increased risk of breast cancer and breast cancer recurrence. (foodforbreastcancer.com)
  • Semglee is reported to be the cheapest available insulin glargine-equivalent on the market, with a 65% discount from the list price of Lantus . (diabeticsmart.com)
  • Lantus v Levemir -- who has been on both? (diabetesforum.com)
  • Levemir usually lasts for 12-16 hours and in no way as long as Lantus. (diabetesforum.com)
  • My last bit of advice: if switching from Lantus to Levemir, you may get odd BG readings for a bit as I've found the doses don't quite match up all the time, and they react differently to certain foods. (diabetes.co.uk)
  • She was on Lantus before they changed her to Levemir, she didnt like the sting of Lantus got upset amd was starting to refuse. (diabetes.co.uk)
  • While biosimilars are usually not as inexpensive as "generic" versions of drugs, because biosimilars are more expensive to manufacture, they do provide cheaper alternatives to brand name drugs, in this case, Lantus (and Levemir, Tresiba, and Toujeo). (diabeticsmart.com)
  • In the basal category, Novo Nordisk's Levemir® has long been second to Sanofi's Lantus, despite steadily increasing share over time. (ozmosi.com)
  • I've finally worked out the dosage on my Lantus (long-lasting insulin) to where my morning lows are about 75, which is a manageable number that does not render me brain-dead. (veronicascornucopia.com)
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  • The FDA has yet to classify Semglee as "biosimilar" or "interchangeable" to Lantus due to the need for additional review - so for now, Semglee should be considered a new basal insulin option for people with diabetes. (diabeticsmart.com)
  • Further, because Semglee is thought to be essentially equivalent to Lantus, it should provide an important and practical option for basal insulin users who are concerned about insulin costs and do not have a route to pay less - this is far more people than often considered. (diabeticsmart.com)
  • The biosimilar designation would mean that Semglee officially has bioactivity and clinical efficacy that are not different from Lantus, but are not necessarily exactly the same. (diabeticsmart.com)
  • The patient reports that he is out of his Lantus and metformin because he cannot afford the refill until he gets his disability check. (brilliantnursingpapers.com)
  • I'm a little nervous about the switching since NPH has an onset, peak, and duration that are much different than Lantus (which essentially stays at a steady level). (jillinoisrn.com)
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  • Sanofi, a multinational pharmaceutical company, needed a mobile application to facilitate prescribing Lantus medicine dosages to their patients. (code95.com)
  • If that does not help, you may need to split your total daily dose in 1/2 and take Lantus twice a day. (diabetesforum.com)
  • I'm type 1 and initially was put on Lantus once daily. (diabetesforum.com)
  • But the doctor and diabetes educator, and the books Think Like a Pancreas and Using Insulin, say to adapt Lantus so your morning fasting BSL is correct and you are not having night hypos. (diabetesforum.com)
  • The French drugmaker's diabetes revenues have fallen since 2015, slumping some 11 percent last year alone, as its patent-expired Lantus insulin is being squeezed by pricing pressure in the United States, the world's-largest health market. (franchiseindia.com)
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  • You thought you were at the right dose, but Lantus does some mysterious things. (diabetesforum.com)