A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
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Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Hemoglobin A, Glycosylated
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
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2000 Sanofi Aventis Lantus insulin "glargine" analogue approved for clinical use in the US and Europe. 2004 Sanofi Aventis ...
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The company was started by Sheridan Snyder and George M. Whitesides in 1981. Genzyme's scientific founder was Henry Blair who had a contract with the National Institutes of Health (NIH) to produce modified enzymes for the NIH to test in clinical trials. Blair was a technician at the New England Enzyme Center at Tufts Medical School. Genzyme's first office was an old clothing warehouse adjacent to Tufts Medical School. In 1981,with the help of venture capital funding, the company made its first acquisition; Whatman Biochemicals Ltd. In 1982, it made its second acquisition, British-based Koch-Light Laboratories, later becoming Genzyme Pharmaceutical and Fine Chemicals. Henri Termeer joined Genzyme as its president in 1983 and worked to redirect the company, which by this time had reached a valuation of $100 million, from its focus on diagnostic enzymes to modified enzymes for use as human therapeutics. In 1984, Robin Berman, MD, who volunteered at the NIH, had a three-year-old ...
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- Insulin glargine, marketed under the names Lantus among others, is a long-acting insulin, used in the management of type I and type II diabetes. (wikipedia.org)
- citation needed] The investment in the production of Lantus and insulin pen manufacturing in Frankfurt-Höchst cost €700 million. (wikipedia.org)
- Some studies have reported that long-term use of insulin glargine ( Lantus ) is associated with increased risk of breast cancer and breast cancer recurrence. (foodforbreastcancer.com)
- Semglee is reported to be the cheapest available insulin glargine-equivalent on the market, with a 65% discount from the list price of Lantus . (diabeticsmart.com)
- Lantus v Levemir -- who has been on both? (diabetesforum.com)
- Levemir usually lasts for 12-16 hours and in no way as long as Lantus. (diabetesforum.com)
- My last bit of advice: if switching from Lantus to Levemir, you may get odd BG readings for a bit as I've found the doses don't quite match up all the time, and they react differently to certain foods. (diabetes.co.uk)
- She was on Lantus before they changed her to Levemir, she didnt like the sting of Lantus got upset amd was starting to refuse. (diabetes.co.uk)
- While biosimilars are usually not as inexpensive as "generic" versions of drugs, because biosimilars are more expensive to manufacture, they do provide cheaper alternatives to brand name drugs, in this case, Lantus (and Levemir, Tresiba, and Toujeo). (diabeticsmart.com)
- In the basal category, Novo Nordisk's Levemir® has long been second to Sanofi's Lantus, despite steadily increasing share over time. (ozmosi.com)
- I've finally worked out the dosage on my Lantus (long-lasting insulin) to where my morning lows are about 75, which is a manageable number that does not render me brain-dead. (veronicascornucopia.com)
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- The FDA has yet to classify Semglee as "biosimilar" or "interchangeable" to Lantus due to the need for additional review - so for now, Semglee should be considered a new basal insulin option for people with diabetes. (diabeticsmart.com)
- Further, because Semglee is thought to be essentially equivalent to Lantus, it should provide an important and practical option for basal insulin users who are concerned about insulin costs and do not have a route to pay less - this is far more people than often considered. (diabeticsmart.com)
- The biosimilar designation would mean that Semglee officially has bioactivity and clinical efficacy that are not different from Lantus, but are not necessarily exactly the same. (diabeticsmart.com)
- The patient reports that he is out of his Lantus and metformin because he cannot afford the refill until he gets his disability check. (brilliantnursingpapers.com)
- I'm a little nervous about the switching since NPH has an onset, peak, and duration that are much different than Lantus (which essentially stays at a steady level). (jillinoisrn.com)
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- Sanofi, a multinational pharmaceutical company, needed a mobile application to facilitate prescribing Lantus medicine dosages to their patients. (code95.com)
- But the doctor and diabetes educator, and the books Think Like a Pancreas and Using Insulin, say to adapt Lantus so your morning fasting BSL is correct and you are not having night hypos. (diabetesforum.com)
- The French drugmaker's diabetes revenues have fallen since 2015, slumping some 11 percent last year alone, as its patent-expired Lantus insulin is being squeezed by pricing pressure in the United States, the world's-largest health market. (franchiseindia.com)
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- You thought you were at the right dose, but Lantus does some mysterious things. (diabetesforum.com)