Kupffer cells. Medical search

Kupffer Cells: Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Gadolinium: Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Endothelium: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.Endotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Poly I: A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Hepatitis: INFLAMMATION of the LIVER.Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Drug-Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Liver Diseases: Pathological processes of the LIVER.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Mononuclear Phagocyte System: Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. It includes MACROPHAGES and their precursors; PHAGOCYTES; KUPFFER CELLS; HISTIOCYTES; DENDRITIC CELLS; LANGERHANS CELLS; and MICROGLIA. The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (From Illustrated Dictionary of Immunology, 2d ed.)Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Peroxisome Proliferators: A class of nongenotoxic CARCINOGENS that induce the production of hepatic PEROXISOMES and induce hepatic neoplasms after long-term administration.Zymosan Mice, Inbred C57BLAntigens, CD14: Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.Latex: A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.Alanine Transaminase: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.Receptors, Scavenger: A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.Liver Cirrhosis, Experimental: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Receptors, Lipoprotein: Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.Phagocytes: Cells that can carry out the process of PHAGOCYTOSIS.Macrophage Activation: The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.Macrophages, Peritoneal: Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.Nitric Acid: Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed)Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Syringes: Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)Inguinal Canal: The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.Appendix: A worm-like blind tube extension from the CECUM.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Books Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Liver Regeneration: Repair or renewal of hepatic tissue.Regeneration: The physiological renewal, repair, or replacement of tissue.Interferon Type I: Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Dictionaries, Medical Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Dictionaries, Chemical

Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. (1/1142)

CD14 is a lipopolysaccharide (LPS) receptor distributed largely in macrophages, monocytes, and neutrophils; however, the role of CD14 in activation of Kupffer cells by LPS remains controversial. The purpose of this study was to determine if different methods used to isolate Kupffer cells affect CD14. Kupffer cells were isolated by collagenase (0.025%) or collagenase-Pronase (0.02%) perfusion and differential centrifugation using Percoll gradients and cultured for 24 h before experiments. CD14 mRNA was detected by RT-PCR from Kupffer cell total RNA as well as from peritoneal macrophages. Western blotting showed that Kupffer cells prepared with collagenase possess CD14; however, it was absent in cells obtained by collagenase-Pronase perfusion. Intracellular calcium in Kupffer cells prepared with collagenase was increased transiently to levels around 300 nM by addition of LPS with 5% rat serum, which contains LPS binding protein. This increase in intracellular calcium was totally serum dependent. Moreover, LPS-induced increases in intracellular calcium in Kupffer cells were blunted significantly (40% of controls) when cells were treated with phosphatidylinositol-specific phospholipase C, which cleaves CD14 from the plasma membrane. However, intracellular calcium did not increase when LPS was added to cells prepared by collagenase-Pronase perfusion even in the presence of serum. These cells were viable, however, because ATP increased intracellular calcium to the same levels as cells prepared with collagenase perfusion. Tumor necrosis factor-alpha (TNF-alpha) mRNA was increased in Kupffer cells prepared with collagenase perfusion 1 h after addition of LPS, an effect potentiated over twofold by serum; however, serum did not increase TNF-alpha mRNA in cells isolated via collagenase-Pronase perfusion. Moreover, treatment with Pronase rapidly decreased CD14 on mouse macrophages (RAW 264.7 cells) and Kupffer cells. These findings indicate that Pronase cleaves CD14 from Kupffer cells, whereas collagenase perfusion does not, providing an explanation for why Kupffer cells do not exhibit a CD14-mediated pathway when prepared with procedures using Pronase. It is concluded that Kupffer cells indeed contain a functional CD14 LPS receptor when prepared gently. (+info)

Effects of Ro 31-8220 on lipopolysaccharides-induced hepatotoxicity and release of tumor necrosis factor from rat Kupffer cells. (2/1142)

AIM: To investigate protein kinase C (PKC) functions on lipopolysaccharide (LPS)-induced hepatotoxicity, a new potent PKC inhibitor Ro 31-8220 (Ro) was used to detect its effect on LPS-induced hepatotoxicity in rat hepatocytes and tumor necrosis factor (TNF) release from rat Kupffer cells (KC). METHODS: Hepatocytes (containing KC) were incubated with LPS (10 mg.L-1) and Ro (0.1-10 mumol.L-1) for 24 h, alanine aminotransferase (AlaA) leakage in the culture as indication of hepatotoxicity. The TNF activity in the supernatant of rat KC culture with LPS in the presence of Ro (0.1-10 mumol.L-1) was monitored by the L929 target cell lytic assay. RESULTS: Ro (0.1-10 mumol.L-1) reduced AlaA leakage in the hepatocyte culture. Ro inhibited dose-dependently the LPS-induced TNF production from rat KC. CONCLUSION: PKC inhibitor Ro protects the hepatocytes from LPS-induced cytotoxicity and inhibits the LPS-induced TNF production from rat KC. (+info)

Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (3/1142)

AIM: To study the possible involvement of Kupffer cells (KC) in immunological liver injury in mice. METHODS: Liver injury was induced by i.v. injection of Bacillus Calmette-Guerin (BCG) 5 x 10(7) viable bacilli followed by i.v. injection of lipopolysaccharides (LPS) 7.5 micrograms to each mouse. Indian ink and silica were i.v. injected to suppress KC and retinol was given po to stimulate KC in these mice. Plasma alanine aminotransferase (AlaAT), aspatate aminotransferase (AspAT), nitric oxide (NO), and liver tissue were examined. RESULTS: Injection of LPS following BCG injection resulted in a remarkable elevation of plasma NO, AlaAT, and AspAT levels, and severe liver damage. The damages were enhanced by the activation of KC with retinol and reduced by suppression of KC with silica and Indian ink. CONCLUSION: The degree of liver injury induced by BCG + LPS is closely correlated with the status of KC, and NO from KC plays an important role in the pathogenesis of the liver damage in mice. (+info)

Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. (4/1142)

Fever improves survival in acute infections, but the effects of increased core temperature on host defenses are poorly understood. Tumor necrosis factor alpha (TNF-alpha) is an early activator of host defenses and a major endogenous pyrogen. TNF-alpha expression is essential for survival in bacterial infections but, if disregulated, can cause tissue injury. In this study, we show that passively increasing core temperature in mice from the basal (36.5 to 37.5 degrees C) to the febrile (39.5 to 40 degrees C) range modifies systemic TNF-alpha expression in response to bacterial endotoxin (lipopolysaccharide). The early TNF-alpha secretion rate is enhanced, but the duration of maximal TNF-alpha production is shortened. We identified Kupffer cells as the predominant source of the excess TNF-alpha production in the warmer animals. The enhanced early TNF-alpha production observed at the higher temperature in vivo could not be demonstrated in isolated Kupffer cells or in precision-cut liver slices in vitro, indicating the participation of indirect pathways. Therefore, expression of the endogenous pyrogen TNF-alpha is regulated by increments in core temperature during fever, generating an enhanced early, self-limited TNF-alpha pulse. (+info)

Intravenous glycine improves survival in rat liver transplantation. (5/1142)

In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015-1020, 1998). The development of harvest-dependent graft injury upon reperfusion can be prevented with GdCl3, a rare earth metal and Kupffer cell toxicant, but it cannot be used in clinical liver transplantation because of its potential toxicity. Thus the effect of glycine, which prevents activation of Kupffer cells, was assessed here. Minimal dissection of the liver for 12 min plus 13 min without manipulation had no effect on survival (100%). However, gentle manipulation decreased survival to 46% in the control group. Furthermore, serum transaminases and liver necrosis were elevated 4- to 12-fold 8 h after transplantation. After organ harvest, the rate of entry and exit of fluorescein dextran, a dye confined to the vascular space, was decreased about twofold, indicating disturbances in the hepatic microcirculation. Pimonidazole binding, which detects hypoxia, increased about twofold after organ manipulation, and Kupffer cells isolated from manipulated livers produced threefold more tumor necrosis factor-alpha after lipopolysaccharide than controls. Glycine given intravenously to the donor increased the serum glycine concentration about sevenfold and largely prevented the effect of gentle organ manipulation on all parameters studied. These data indicate for the first time that pretreatment of donors with intravenous glycine minimizes reperfusion injury due to organ manipulation during harvest and after liver transplantation. (+info)

A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: implications for clinical efficacy in treatment of Gaucher disease. (6/1142)

The objective of these studies was to characterize the macrophage mannose receptor binding and pharmacological properties of carbohydrate remodeled human placental-derived and recombinant beta-glucocerebrosidase (pGCR and rGCR, respectively). These are similar but not identical molecules that were developed as enzyme replacement therapies for Gaucher disease. Both undergo oligosaccharide remodeling during purification to expose terminal mannose sugar residues. Competitive binding data indicated carbohydrate remodeling improved targeting to mannose receptors over native enzyme by two orders of magnitude. Mannose receptor dissociation constants (Kd) for pGCR and rGCR were each 13 nmol/L. At 37 degrees C, 95% of the total macrophage binding was mannose receptor specific. In vivo, pGCR and rGCR were cleared from circulation by a saturable pathway. The serum half-life (t1/2) was 3 minutes when less than saturable amounts were injected intravenously (IV) into mice. Twenty minutes postdose, beta-glucocerebrosidase activity increased over endogenous levels in all tissues examined. Fifty percent of the injected activity was recovered. Ninety-five percent of recovered activity was in the liver. Parenchymal cells (PC), Kupffer cells (KC), and liver endothelium cells (LEC) were responsible for 75%, 22%, and 3%, respectively, of the hepatocellular uptake of rGCR and for 76%, 11%, and 12%, respectively, of the hepatocellular uptake of pGCR. Both molecules had poor stability in LEC and relatively long terminal half-lives in PC (t1/2 = 2 days) and KC (t1/2 = 3 days). (+info)

Infection of primary cultures of human Kupffer cells by Dengue virus: no viral progeny synthesis, but cytokine production is evident. (7/1142)

We investigated the ability of dengue virus to invade human primary Kupffer cells and to complete its life cycle. The virus effectively penetrated Kupffer cells, but the infection did not result in any viral progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and were cleared by phagocytosis. Infected Kupffer cells produced soluble mediators that could intervene in dengue virus pathogenesis. (+info)

Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide. (8/1142)

The generation of reactive oxygen species (ROS) by activated Kupffer cells contributes to liver injury following liver preservation, shock, or endotoxemia. Pharmacological interventions to protect liver cells against this inflammatory response of Kupffer cells have not yet been established. Atrial natriuretic peptide (ANP) protects the liver against ischemia-reperfusion injury, suggesting a possible modulation of Kupffer cell-mediated cytotoxicity. Therefore, we investigated the mechanism of cytoprotection by ANP during Kupffer cell activation in perfused rat livers of male Sprague-Dawley rats. Activation of Kupffer cells by zymosan (150 microgram/ml) resulted in considerable cell damage, as assessed by the sinusoidal release of lactate dehydrogenase and purine nucleoside phosphorylase. Cell damage was almost completely prevented by superoxide dismutase (50 U/ml) and catalase (150 U/ml), indicating ROS-related liver injury. ANP (200 nM) reduced Kupffer cell-induced injury via the guanylyl cyclase-coupled A receptor (GCA receptor) and cGMP: mRNA expression of the GCA receptor was found in hepatocytes, endothelial cells, and Kupffer cells, and the cGMP analog 8-bromo-cGMP (8-BrcGMP; 50 microM) was as potent as ANP in protecting from zymosan-induced cell damage. ANP and 8-BrcGMP significantly attenuated the prolonged increase of hepatic vascular resistance when Kupffer cell activation occurred. Furthermore, both compounds reduced oxidative cell damage following infusion of H2O2 (500 microM). In contrast, superoxide anion formation of isolated Kupffer cells was not affected by ANP and only moderately reduced by 8-BrcGMP. In conclusion, ANP protects the liver against Kupffer cell-related oxidant stress. This hormonal protection is mediated via the GCA receptor and cGMP, suggesting that the cGMP receptor plays a critical role in controlling oxidative cell damage. Thus ANP signaling should be considered as a new pharmacological target for protecting liver cells against the inflammatory response of activated Kupffer cells without eliminating the vital host defense function of these cells. (+info)

... giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance ... Kupffer cells, osteoclasts, monocytes, and activated microglia in rat tissues. In this species, it is expressed in most ... Kupffer cells, microglia). Human CD68 is a transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a ... "Tri-iodothyronine differentially induces Kupffer cell ED1/ED2 subpopulations". Molecular Aspects of Medicine. 25 (1-2): 183-190 ...

Kupffer cells are scattered between endothelial cells; they are part of the reticuloendothelial system and phagocytose spent ... A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 70-85% of the liver's mass. These cells ... In the first step, the liver is placed in an isotonic solution, in which calcium is removed to disrupt cell-cell tight ... The hepatocyte plates are one cell thick in mammals and two cells thick in the chicken. Sinusoids display a discontinuous, ...

They undergo schizogony in the hepatocytes and Kupffer cells. They then invade the nervous tissue of the rodent host, forming ...

... being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly ... Main liver cells are hepatocytes, Kupffer cells, and hepatic stellate cells; each one with a specific function. Cytology is the ... The main function of the Kupffer cells is the destruction of old blood cells that go through the liver. In the perisinusoidal ... there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages). The liver is the biggest ...

Andrzej Śródka, Ryszard W. Gryglewski, Wojciech Szczepański: Browicz or Kupffer Cells? Journal of Physiology and Pharmacology, ... and in 1898 was the first to correctly identify the liver's Kupffer cells as specialized macrophages. He also performed ...

Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD (2004). "Kupffer cell-mediated IL-2 suppression of CYP3A activity in human ...

Hinglais N, Kazatchkine MD, Mandet C, Appay MD, Bariety J (1989). "Human liver Kupffer cells express CR1, CR3, and CR4 ... protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces; ... Donius LR, Handy JM, Weis JJ, Weis JH (Jul 2013). "Optimal Germinal Center B Cell Activation and T-Dependent Antibody Responses ... The gene is expressed principally on erythrocytes, monocytes, neutrophils and B cells but is also present on some T lymphocytes ...

... which causes osmotic lysis of the target cell. Kupffer cells and other macrophage cell types help clear complement-coated ... Host cells don't accumulate cell surface C3b (and the proteolytic fragment of C3b called iC3b) because this is prevented by the ... the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and ... In contrast, when the internal thioester of C3 reacts with a hydroxyl or amino group of a molecule on the surface of a cell or ...

... such as bacterial cell-wall components, and remove them from the blood. The Kupffer cells in the liver are particularly rich in ... CD36 has been thought to be implicated in cell adhesion, in the phagocytosis of apoptotic cells, and in the metabolism of long- ... Lectin-like oxidized LDL receptor-1 (LOX-1) was isolated from an aortic endothelial cell, and recently it has been discovered ... Scavenger receptors are receptors on macrophages and other cells that bind to numerous ligands, ...

Diminished organelle motion in murine Kupffer cells during the erythrocytic stage of malaria. J R Soc Interface. 2011 May 6;8( ... Am J Respir Cell Mol Biol. 2006; 35:415-23. Trujillo JR, Rogers R, Molina RM, Dangond F, McLane MF, Essex M, Brain JD. Non- ... Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2. Am J Respir Cell Mol Biol ...

"Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution". AIDS ( ... "Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire". Journal of Immunology. 181 (9): 6435-6446 ... "High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral ...

2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 ( ... analysis of its promoter indicates a region conveying cell type-specific expression". Mol. Cell. Biol. 10 (6): 2738-48. PMC ... Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... Cell. Biol. 7 (9): 3221-30. PMC 367958 . PMID 3670312. Oikawa S, Nakazato H, Kosaki G (1987). "Primary structure of human ...

In the liver, Kupffer cells store excess iron from catabolism of heme from the breakdown of red blood cells. In bone marrow and ... The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the ... Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus ... Formation of new red blood cells (RBCs) and white blood cells (WBCs). Destruction of old RBCs and WBCs Formation of plasma ...

During late phase the appearance is isoechoic or hypoechoic, due to lack of Kupffer cells. Malignant liver tumors develop on ... Systemic therapies are procedures based on the affinity of certain molecules to inhibit either tumor cell replication or ...

The Kupffer cells of the liver then phagocytose endotoxin, stimulating the release of TNF-α. TNF-α then triggers apoptotic ... Fatty change, or steatosis is the accumulation of fatty acids in liver cells. These can be seen as fatty globules under the ... Subsequently, the higher levels of fatty acids signal the liver cells to compound it to glycerol to form triglycerides. These ... These factors cause inflammation, apoptosis and eventually fibrosis of liver cells. Why this occurs in only a few individuals ...

... from Kupffer Cells) or nitrous oxide (NO) and endothelin-1 (ET-1). ET-1 is the most potent vasoconstrictor under investigation ... The muscular pulmonary arteries become fibrotic and hypertrophy while the smaller arteries lose smooth muscle cells and their ... Prostaglandin PGE1 (Alprostadil) binds G-protein linked cell surface receptors that activate adenylate cyclase to relax ...

These individuals are likely to have liver and spleen iron overload, primarily in Kupffer cells and other macrophages. Because ... Iron accumulates preferentially in Kupffer cells, which are located in the liver, and serum ferritin increases; less iron is ... Iron in the bloodstream is then bound by transferrin, which carries the iron to target cells. Iron is stored in cells and blood ... More ferritin is produced to suppress oxidative cell damage, although the amount of ferritin that cells can accumulate is ...

Kupffer cells and sinusoidal endothelial cells from rat liver". Hepatology. 11 (2): 199-204. doi:10.1002/hep.1840110207. PMID ... such as cell aggregation, migration, proliferation and activation; cell-cell and cell-substrate adhesion; endocytosis of HA, ... To date, it is recognized as the main cell surface receptor for HA. CD44 mediates cell interaction with HA and the binding of ... Finally, in the formation of a metastatic lesion, HAS produces HA to allow the cancer cell to interact with native cells at the ...

... sinusoidal endothelial cells, and phagocytic Kupffer cells. Hepatic stellate cells are non-parenchymal cells found in the ... shows two major types of liver cell: parenchymal cells and non-parenchymal cells. 70-85% of the liver volume is occupied by ... Non-parenchymal cells constitute 40% of the total number of liver cells but only 6.5% of its volume. The liver sinusoids are ... The fetal liver releases some blood stem cells that migrate to the fetal thymus, creating the T-cells or T-lymphocytes. After ...

In 1876, Karl Wilhelm von Kupffer described the properties of some liver cells now called Kupffer cell. In 1883, Hugo Kronecker ...

The liver sinusoidal endothelium reappears after being eclipsed by the Kupffer cell: a 20th century biological delusion ... These cells (LSEC) take up other viruses and other particles in their capacity as the body's garbage dump, clearing small ... Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG ... Antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem. Sep 25;261(27):12856-64 ...

The protein is most prevalent in the kidney and the liver where it is found in Kupffer cells. STARD5 binds both cholesterol and ... Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. ... Increased levels of StarD5 increase free cholesterol in the cell. Cholesterol homeostasis is regulated, at least in part, by ... "START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells". Molecular and Cellular ...

Kupffer cells are located inside the sinusoids and can take up and destroy foreign material such as bacteria. Hepatic stellate ... The sinusoidal endothelial cells are cultured for a variety of research purposes. The utility of these cells are of particular ... One problem to overcome is the reversing of cellular differentiation that has made these cells highly specialized ... September 2007). "Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular ...

Peripheral macrophage as well as liver sinusoidal endothelial cells and Kupffer cells have been implicated in this process, ... is found on many cells, including endothelial cells, smooth muscle, cells of the immune system[which?] from tissue such as lung ... AGEs affect nearly every type of cell and molecule in the body and are thought to be one factor in aging and some age-related ... Binding cells-including macrophage, endothelial, and mesangial-to induce the secretion of a variety of cytokines. Enhanced ...

2006). "The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes ... The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of ... 1998). "Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous ... 2006). "Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues". Br ...

... including Kupffer cells and microglia), dendritic cells, NK cells and renal proximal tubule cells. Absence of the enzyme in ... 2012). "Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA ... it remains bioactive and may pass from cell to cell in vivo for many weeks. The LPS-exposed mice develop strikingly high titers ... Cell Host Microbe. 4: 293-302. doi:10.1016/j.chom.2008.06.009. PMC 2607035 . PMID 18779055. Lu M, Varley AW, Munford RS (2013 ...

The blood carries the virus to its target, the liver, where it multiplies within hepatocytes and Kupffer cells (liver ... The virus exits the host cell by lysis and viroporins. Virions are secreted into the bile and released in stool. HAV is ... The enzyme comes from the liver cells damaged by the virus. Hepatovirus A is present in the blood (viremia) and feces of ... Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates endocytosis. Replication ...

... sinusoids and Kupffer cells" Anatomy photo: digestive/mammal/liver5/liver7 - Comparative Organology at University of California ... The perisinusoidal space also contains hepatic stellate cells (also known as cells of Ito), which store fat or fat soluble ... "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse" Histology image: 15204loa - Histology ... vitamins including vitamin A). A variety of insults that cause inflammation can result in the cells transforming into ...

當血液中的紅血球死亡，紅血球中血紅蛋白的血紅素會於肝臟的庫佛氏

... probably indirectly via Kupffer cells), which leads to eosinophilic degradation of these cells and to the release of cytokines ... The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surfaces via specific ... After entering the host cell, the viral genome is replicated in the rough endoplasmic reticulum (ER) and in the so-called ... After transmission from a mosquito, the viruses replicate in the lymph nodes and infect dendritic cells in particular. From ...

Kaposi's sarcoma (KS) - Karnofsky score - killer T cells - KSHV - Kupffer cells LEdit. Langerhans cells - LAS - lentivirus - ... T suppressor cells - T4 cell - T4 cells (T-helper cells) - T8 cells - Tanner staging - TAT - TB - template - TeachAIDS - ... B-cell lymphoma - B cells - B lymphocytes (B cells) - bactericidal - bacteriostatic - bacterium - baculovirus - baseline - ... cells - CDC National Prevention Information Network (CDC-NPIN) - cell lines - cell-mediated immunity (CMI) - cellular immunity ...

... which become known as Kupffer cells. These cells still serve a role in the immune system. ... T cells: *CD4+ helper T cells: T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...

Kupffer cells, and mast cells. These cells present receptors contained on the surface or within the cell, named pattern ... Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a ... Mast cells[edit]. Main article: Mast cell. Mast cells are a type of innate immune cell that reside in connective tissue and in ... Natural killer cells[edit]. Main article: Natural killer cell. Natural killer cells (NK cells) are a component of the innate ...

These include the various cells of the gastric glands, taste cells, pancreatic duct cells, enterocytes and microfold cells. ... Another product is iron, which is used in the formation of new blood cells in the bone marrow.[5] Medicine treats the spleen ... The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the ... The spleen is the largest lymphoid organ in the body but has other functions.[23] It breaks down both red and white blood cells ...

... they regulate other immune cell functions (e.g., CD4+ T cell, dendritic cell, B cell, mast cell, neutrophil, and basophil ... Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... Mast cells[edit]. See article: Mast cell. Mast cells are a type of granulocyte that are present in tissues;[3] they mediate ... Basophils are one of the least abundant cells in bone marrow and blood (occurring at less than two percent of all cells). Like ...

"Cloning of a new cytokine that induces IFN-gamma production by T cells". Department of Bacteriology, Hyogo College of Medicine ... IL-18 umumnya merupakan sekresi makrofaga dan sel Kupffer.[2] Peningkatan ekspresi IL-18 ditemukan pada beberapa jenis kanker, ...

An alternative source of beta cells, such insulin-producing cells derived from adult stem cells or progenitor cells would ... activates beta cells and inhibits alpha cells. *Glycogen/Glucagon: activates alpha cells which activates beta cells and delta ... PP cells (gamma cells or F cells) producing pancreatic polypeptide (,5%). It has been recognized that the cytoarchitecture of ... In rat islets, endocrine cell subsets are distributed as follows:[6] *Alpha cells producing glucagon (20% of total islet cells) ...

Kupffer cells and sinusoidal endothelial cells from rat liver". Hepatology. 11 (2): 199-204. doi:10.1002/hep.1840110207. PMID ... such as cell aggregation, migration, proliferation and activation; cell-cell and cell-substrate adhesion; endocytosis of HA, ... Cell migrationEdit. Cell migration is essential for the formation of granulation tissue.[26] The early stage of granulation ... Cell receptors for hyaluronic acidEdit. So far, cell receptors that have been identified for HA fall into three main groups: ...

This promotes further liver damage.[35] Non-parenchymal cells such as Kupffer cells, fat storing stellate cells, and leukocytes ... such as stem cell-derived hepatocyte-like cells, that are capable of detecting toxicity early in the drug development process.[ ... This is the most common type of drug-induced liver cell necrosis where the injury is largely confined to a particular zone of ... Greenhough S, Hay DC (2012). "Stem Cell-Based Toxicity Screening: Recent Advances in Hepatocyte Generation". Pharm Med. 26 (2 ...

... which causes osmotic lysis of the target cell. Kupffer cells and other macrophage cell types help clear complement-coated ... Host cells don't accumulate cell surface C3b (and the proteolytic fragment of C3b called iC3b) because this is prevented by the ... the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and ... This creates a hole or pore in the membrane that can kill or damage the pathogen or cell.[citation needed] ...

Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension ... this makes plasma the extracellular matrix of blood cells. It makes up about 55% of the body's total blood volume.[1] It is the ... When donating whole blood or packed red blood cell (PRBC) transfusions, O- is the most desirable and is considered a "universal ...

當血液中的紅血球死亡，紅血球中血紅蛋白的血紅素會於肝臟的庫佛氏

Histiosit " Sel Kupffer " Alveolar " Pleural " Peritoneal " Langerhans's cell. Radang. DC. Mieloid. Plasmasitoid. ...

Any ANC , 1500 cells / mm3 is considered neutropenia, but ,500 cells / mm3 is considered severe.[46] There is also new research ... HSC=Hematopoietic stem cell, Progenitor=Progenitor cell, L-blast=lymphoblast, Lymphocyte, Mo-blast=Monoblast, Monocyte, ... Whereas basophilic white blood cells stain dark blue and eosinophilic white blood cells stain bright red, neutrophils stain a ... Reference ranges for blood tests of white blood cells, comparing neutrophil amount (shown in pink) with that of other cells ...

... including Kupffer cells), and some dendritic cells.[10] It is composed of two extracellular Ig-like domains, and is a member of ... Langerhans cells Phagocytosis. Degranulation (eosinophils) FcγRIIB1 (CD32) IgG Low (Kd , 10−7 M) B Cells. Mast cells No ... Mast cells. Follicular dendritic cells Induction of microbe killing FcεRI IgE High (Kd ~ 10−10 M) Mast cells. Eosinophils. ... On NK cellsEdit. The Fc receptor on NK cells recognize IgG that is bound to the surface of a pathogen-infected target cell and ...

I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation". European ... Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate ... Suppression of primary M, G, and A plaque-forming cell responses in mouse spleen cell cultures by class-specific antibody to ... There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system.[27] ...

... such as fat cells, muscle cells, liver cells (and also in the endothelial cells, Kupffer cells and stellate cells of the liver ... cell membrane. • presynaptic membrane. • mitochondrion. • mitochondrial outer membrane. • cell projection. • integral component ... "Cell. 167 (3): 750-762.e14. doi:10.1016/j.cell.2016.10.004. PMC 5322940. PMID 27768894.. ... In the retina, they are expressed in the photoreceptors, inner plexiform, outer plexiform, bipolar cells, ganglion cells, and ...

"Redox regulation of thyroid hormone-induced Kupffer cell-dependent IkappaB-alpha phosphorylation in relation to inducible ... "Hepatic Stellate Cell in Fibrosis: Stellate Cell Activation". Division of Liver Diseases, Mount Sinai School of Medicine; Scott ... "Stem cells, cell transplantation and liver repopulation". Marion Bessin Liver Research Center, Division of Hepatology, ... "Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury". Division of Radiooncology, Deutsches ...

Liver biopsy findings will generally show a bright yellow-orange color, enlarged, lipid-laden hepatocytes and Kupffer cells, ... Some children with LAL-D have had an experimental therapy called hematopoietic stem cell transplantation (HSCT), also known as ... and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease". Bone Marrow Transplantation. 43 (1): ... eventually leading to life-threatening problems such as extremely low levels of circulating red blood cells (severe anemia), ...

"Cell. 130 (6): 1005-18. doi:10.1016/j.cell.2007.07.020. PMC 2586609 . PMID 17889646.. ... hspb7 also acts in the downregulation of Kupffer vesicles which is responsible for regulation of left-right asymmetry of heart ... Tumor cells usually express only a few neo-antigens, which can be targeted by immune system and also not all tumor cells ... Also isolated HSPs from tumour cells are able to act as a specific anti-tumour vaccine by themselves.[28][26] Tumour cells ...

Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Dehmlow, Carola; ... In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells Journal of ...

Dendritic cells (Langerhans cells, Follicular dendritic cells). Monocytes/Macrophages (Histiocytes, Kupffer cells, Langhans ... T cells: Cytotoxic CD8+, Helper CD4+/Regulatory, γδ, Natural Killer T cell. B cells: Plasma, Memory. Natural killer cells ( ... Natural killer cells: cell a liban dang virus ampong tumor cell.. malalam mikukulayan, e makasentru. bukud mung NK-cells [5]. ... Deng γδ T cell atin lang alternatibung T cell receptor, e anti kareng CD4+ and CD8+ αβ T cell, at kayawig do reng helper T cell ...

Investigations concerning Kupffer cells are hampered because in humans, Kupffer cells are only accessible for ... Once a T cell has recognized its particular antigen on the surface of an aberrant cell, the T cell becomes an activated ... The processed antigen is then presented in MHCII on the surface of the B-cell. T cells that express the T cell receptor which ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ...

Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... "Distinguishing mast cell and granulocyte differentiation at the single-cell level". Cell Stem Cell. 6 (4): 361-8. doi:10.1016/j ... This article is about a type of blood cell. For the endocrine cell of the anterior pituitary, see basophil cell. ... Both cell types store histamine, a chemical that is secreted by the cells when stimulated. However, they arise from different ...

Cell Genet. 52 (1-2): 77-8. doi:10.1159/000132844. PMID 2612218.. Pemeliharaan CS1: Banyak nama: authors list (link) ...

Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized macrophages located in the liver, ... Cell. 124 (5): 915-27. doi:10.1016/j.cell.2005.12.039. PMID 16530040. Michael D. Wheeler (2004). "Endotoxin and Kupffer Cell ... Histology Learning System at Boston University Kupffer Cell Foundation - The mission of the Kupffer cell Foundation is to ... The cells were first observed by Karl Wilhelm von Kupffer in 1876. The scientist called them "Sternzellen" (star cells or ...

en.wikipedia.org

... acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells ... Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental ...

en.wikipedia.org

No data available that match "kupffer cells"

These factors regulate the phenotype of KC themselves, and the phenotypes of neighboring cells, such as hepatocytes, stellate cells, endothelial cells and other immune cells that traffic through the liver. (nih.gov)
The mitochondrial DNA (mtDNA) from hepatocytes of HFD-fed mice induced TNF-α and IL-6 expression in cultured Kupffer cells (KCs), which was attenuated by STING deficiency or pretreatment with BAY11-7082 (an NF-κB inhibitor). (jci.org)
Between the cords of hepatocytes the sinusoids were lined with endothe-lial cells having flattened dark nuclei and Kupffer cells with nuclei projecting into the sinusoids which opened into the central vein. (thefreedictionary.com)
Morphometric Observations: The details of Volume density of hepatocytes (Vvh) and Numerical density of Kupffer cells on the area (Nak) are summarized in Table 4. (thefreedictionary.com)
The researchers used vaccinia virus to infect livers that either could or could not detect type I interferon, or in which only the Kupffer cells or the hepatocytes, the main cell type of the liver, could or could not detect type I interferon. (eurekalert.org)
This is surprising, since hepatocytes are the main target cell for type for infection. (eurekalert.org)
The presence of several proliferative lesions in exposed mice, including multinucleated hepatocytes and oval and Kupffer cell hyperplasia, in the absence of cellul ar necrosis or fibrosis, indicates an isolated proliferative response, and not a regenerative response following liver injury (Thoolen et al. (thefreedictionary.com)
We found that Kupffer cells from Plasmodium -infected livers produced high levels of HGF, which trigger apoptosis of infected hepatocytes through a mitochondrial-independent apoptosis pathway. (frontiersin.org)
Our results raise the hypothesis that paracrine signals derived from Kupffer cell activation are implicated in directing death of hepatocytes infected with the malaria parasite. (frontiersin.org)
This response decreases liver parasite load possibly because type I IFN signaling in myeloid cells contributes to the recruitment of immune cells to the inflammatory foci around infected hepatocytes ( 6 ). (frontiersin.org)
T 3 -induced ROS generation occurs at different subcellular sites of hepatocytes and in the respiratory burst of Kupffer cells, triggering the activation of the transcription factors nuclear factor- κ B (NF- κ B), signal transducer and activator of transcription 3 (STAT3), and activating protein 1 (AP-1). (hindawi.com)
Although ICC has been defined as a tumor arising from cholangiocyte transformation, recent evidence from genetic lineage-tracing experiments has indicated that hepatocytes can be a cellular origin of ICC by directly changing their fate to that of biliary lineage cells. (sigmaaldrich.com)
Here, using a mouse model of ICC, we found that hepatic macrophages called Kupffer cells transiently congregate around the central veins in the liver and express the Notch ligand Jagged-1 coincident with Notch activation in pericentral hepatocytes. (sigmaaldrich.com)
Depletion of Kupffer cells prevents the Notch-mediated cell-fate conversion of hepatocytes to biliary lineage cells, inducing hepatocyte apoptosis and increasing mortality in mice. (sigmaaldrich.com)
For efficient hepatocyte transduction, adenovirus vectors need to evade from Kupffer cell scavenging while delivery to peripheral tissues or tumors could be improved if both scavenging by Kupffer cells and uptake by hepatocytes were blocked. (nih.gov)
Here, we provide evidence that a single point mutation in the hexon capsomere designed to enable defined chemical capsid modifications may permit both detargeting from and targeting to hepatocytes with evasion from Kupffer cell scavenging. (nih.gov)
Kupffer cells are most commonly used in co-culture systems with primary hepatocytes in drug discovery and ADME-Tox studies. (tebu-bio.com)
The Kupffer cell-conditioned media were than added in separate experiments to freshly prepared isolated rat hepatocytes to determine their cytotoxic effect. (soton.ac.uk)
No significant effects on the rate of protein synthesis, as assessed by the incorporation of 14C-leucine on lactate dehydrogenase enzyme release from hepatocytes during 1 h incubation was found as compared with conditioned media from control Kupffer cells. (soton.ac.uk)
It is concluded that under the conditions of the present experiments, factors secreted by cultured Kupffer cells have no cytotoxic effects on isolated rat hepatocytes during short-term incubation. (soton.ac.uk)
Numbers of F4/80 Kupffer cells, relative to numbers of albumin positive hepatocytes, did not show a significant trend over the first 2 postnatal weeks. (biomedcentral.com)
The increasing general agreement is that the cross-talk between hepatocytes, hepatic stellate cells (HSCs) and macrophages in NAFLD has a main role in the derangement of lipid homeostasis, insulin resistance, danger recognition, immune tolerance response and fibrogenesis. (mdpi.com)
Coordinated interactions with hepatocytes induced ID3 expression, whereas endothelial cells and stellate cells induced LXR-α via a synergistic NOTCH-BMP pathway. (researchportal.be)
This study shows that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity. (researchportal.be)

Breiner KM, Schaller H, Knolle PA (2001) Endothelial cell-mediated uptake of a hepatitis B virus: a new concept of liver targeting of hepatotropic microorganisms. (springer.com)
Physically, Kupffer cells (KCs) are interspersed with fenestrated liver sinusoidal endothelial cells in a mosaic fashion to make up the sinusoidal lining. (frontiersin.org)
Kupffer cells (KC), the resident liver macrophages, constitute the liver sinusoids together with other cells such as sinusoidal endothelial cells, hepatic stellate cells, liver-specific natural killer cells and dendritic cells. (bmj.com)
We conclude that pulmonary inflammation induced by acute pancreatitis is mediated by Kupffer cell activation and that pancreatitis induces the expression of P-selectin on pulmonary endothelial cells but this effect is not mediated by Kupffer cells. (csic.es)
Sonazoid was injected into rats and perfused fixed livers were studied by electron microscopy, which revealed that the Sonazoid microbubbles were exclusively internalised in Kupffer cells, i.e. by the macrophages located in the liver sinusoids, and not by parenchymal, stellate or endothelial cells. (biomedsearch.com)
An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias. (dbcls.jp)
The overall objective of this thesis was to investigate whether hydrogen sulfide (H2S), substance P (SP) and Kupffer cells modulate the inflammatory response, organ damage and liver sinusoidal endothelial cells (LSECs) fenestrations in sepsis. (otago.ac.nz)
LSECs are specialised fenestrated endothelial cells in the liver that undergo structural alteration during inflammation and infection. (otago.ac.nz)
The Kupffer cells were identified by their immunoreactivity to the F4/80 antibody, whereas endothelial cells were labelled with the CD-34 antibody. (biomedcentral.com)
In addition, Kupffer cells and endothelial cells were labelled by systemically injected fluorescently labelled latex microspheres. (biomedcentral.com)
The F4/80 positive Kupffer cells were labelled with both large (0.2 μm) and small (0.02 μm) diameter microspheres, while endothelial cells were labelled only with the smaller diameter microspheres. (biomedcentral.com)
KC are found within the sinusoidal lumen, adhering to the liver sinusoidal endothelial cells. (nutriforce.cn)
Kupffer cell loss induced tumor necrosis factor (TNF)- and interleukin-1 (IL-1) receptor-dependent activation of stellate cells and endothelial cells, resulting in the transient production of chemokines and adhesion molecules orchestrating monocyte engraftment. (researchportal.be)

Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. (valorebooks.com)
In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states.Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.Ronald D. Curran is the author of 'Hepatocyte and Kupffer Cell Interactions', published 1992 under ISBN 9780849361098 and ISBN 0849361095. (valorebooks.com)
Using primary hepatocyte cultures, we investigated the role of Kupffer cell-derived hepatocyte growth factor (HGF) in malaria liver stage infection. (frontiersin.org)
Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma. (sigmaaldrich.com)
Notch signaling has been identified as an essential factor for hepatocyte conversion into biliary lineage cells at the onset of ICC. (sigmaaldrich.com)
Vector particles modified with transferrin or, surprisingly, 5,000 Da PEG or dextran increased hepatocyte transduction up to 18-fold independent of the presence of Kupffer cells. (nih.gov)
To control the quality and reproducibility of their isolated primary Kupffer cells, Sekisui XenoTech examined 19 freshly plated hepatocyte and Kupffer cell co-cultures for the presence of Kupffer cells. (tebu-bio.com)
Sekisui XenoTech's Kupffer cell thawing and culturing as well as hepatocyte isolation and plating protocols assure that plated hepatocyte and Kupffer cell co-cultures contain a representative quantity of liver macrophages. (tebu-bio.com)
Hepatocyte apoptosis and of Kupffer cells (KC) and hepatic stellate cells (HSC) interaction were investigated using confocal microscopy. (biomedcentral.com)
hepatocyte A specialized epithelial cell that is the most abundant type of cell in the liver . (encyclopedia.com)
hepatocyte (hip- at -oh-syt) n. the principal cell type in the liver: a large cell with many metabolic functions, including synthesis, storage, detoxification, and bile production. (encyclopedia.com)
Our results demonstrate increased hepatotoxicity and decreased survival after exposure to LPS in both of the obese strains and suggest two mechanisms-altered Kupffer cell function and increased hepatocyte sensitivity to tumor necrosis factor α (TNFα)-that might mediate obesity-related sensitivity to endotoxin. (pnas.org)

Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized macrophages located in the liver, lining the walls of the sinusoids that form part of the mononuclear phagocyte system. (wikipedia.org)
The scientist called them "Sternzellen" (star cells or hepatic stellate cell) but thought, inaccurately, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it. (wikipedia.org)
TNFα will then enter the stellate cell in the liver, leading to collagen synthesis and fibrosis. (wikipedia.org)
Byun JS, Suh YG, Yi HS, Lee YS, Jeong WI (2013) Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. (springer.com)
Some of the highlights include the concept of Kupffer cell activation and the role of these cells in liver inflammation, oxidative stress--related injury, stellate cell activation, and liver fibrosis. (thefreedictionary.com)
A high-cholesterol diet also induces free cholesterol accumulation in hepatic stellate cells, which are activated by inflammation, and exacerbates hepatic fibrosis induced by bile duct ligation or carbon tetrachloride treatment (12). (deepdyve.com)
Hepatic stellate cells and oxidative stress]. (semanticscholar.org)

However, type I interferon seems to be important for Kupffer cells, says Dr. Frenz: "We believe, that type I interferon triggers Kupffer cells to take up infected cells and undergo apoptosis (suicide) afterwards, since surprisingly, Kupffer cells disappear after infection. (eurekalert.org)
This apoptosis mechanism is distinct from cell death that is spontaneously induced in infected cultures and is governed by Fas signaling modulation through a mitochondrial-dependent apoptosis pathway. (frontiersin.org)
Further investigation of the mechanism involved in such suppression revealed that KC could induce apoptosis of the activated T cells. (jimmunol.org)
In summary, our data suggest that KC are ¡°poor¡± stimulators of T cells, and that they can cause tolerance through induction of T cell apoptosis. (jimmunol.org)
Galectin-9 results in expansion of CD4+CD25+FoxP3+CD127low regulatory T cells, contraction of CD4+ effector T cells, and apoptosis of HCV-specific CTLs. (harvard.edu)
In vitro, PGE2 secreted by MSCs inhibited Kupffer cell apoptosis via TLR4-ERK1/2-caspase3 pathway regulation. (springer.com)
The results of the CCK8 assay and flow cytometry showed that, in the OGSD/R group, astrocyte cell viability was downregulated, but astrocyte apoptosis increased. (panelstaff.top)
It also regulates cell growth and differentiation, apoptosis, cell migration, and immune cell function in liver fibrosis/cirrhosis. (intechopen.com)
LPS stimulation of KC resulted in upstream ROS generation and, subsequently, increased FasL expression and consequent Jurkat cell (Fas-positive) apoptosis. (nutriforce.cn)
Exogenous administration of H2O2 stimulated KC FasL expression and subsequent Jurkat cell apoptosis. (nutriforce.cn)
Moreover, KC can directly interact with passenger leukocytes and, thus, may play a role in immunomodulation (21), which includes antigen presentation (27) and induction of T cell apoptosis via Fas-FasL interactions (23). (nutriforce.cn)

Kupffer cells ( kuup -fer) pl. n. phagocytic cells that line the sinusoids of the liver (see macrophage ). (encyclopedia.com)
Fixed MACROPHAGE cells that line the fine blood sinuses (capillaries) of the liver and act as scavengers to remove senescent red blood cells, bacteria and other foreign material. (thefreedictionary.com)
Through this fellowship, we have greatly enhanced our understanding of KC biology and more generally macrophage and dendritic cell (DC) biology, the key cell types, present in almost all organs, which acquire and cue the immune system to respond appropriately to foreign and host agents. (europa.eu)
Cells were evaluated for expression of CD68, a general macrophage marker, by immunofluorescent staining after 3 days in culture. (tebu-bio.com)
Because ER stress is known to induce M2 macrophage polarization, we examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD). (elsevier.com)
Kupffer cells of the developing mouse liver appear quite similar to those of other mammalian species, confirming that the mouse presents a useful animal model for studies of liver macrophage developmental structure and function. (biomedcentral.com)
Our results showed that AS increased FITC-LPS internalization by peritoneal macrophage and liver Kupffer cell, but enhancement of LPS internalization by AS was not related to the clathrin-dependent pathway. (mdpi.com)
Kupffer cells (KC), the resident macrophage population in the liver, comprise one of major populations (20%) of the hepatic nonparenchymal cells. (nutriforce.cn)
A macrophage along a blood vessel, together with its undifferentiated perivascular cells. (tabers.com)
It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. (wikipedia.org)

This study has been performed to examine which cells are responsible for the hepatic clearance of the new ultrasound contrast agent Sonazoid and to study whether uptake of these gas microbubbles disturbs the function of the cells involved. (biomedsearch.com)
Uptake of the Sonazoid perfluorobutane microbubbles by the Kupffer cells following injection of a dose corresponding to 20x the anticipated clinical dose for liver imaging did not result in measurable changes in the uptake and degradation of radioactively labelled albumin microspheres previously shown to be a useful indicator marker for Kupffer cell phagocytosis. (biomedsearch.com)
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (prohealth.com)
The in vitro uptake of B. burgdorferi IRS by isolated rat Kupffer cells was rapid, and within 30 min of the infection, large intracellular aggregates of amorphous material were detectable by immunofluorescence with specific anti-B. burgdorferi antibody. (prohealth.com)
In addition, the uptake of exogenous horseradish peroxidase by Kupffer cells has been investigated. (rupress.org)
Cells immunoreactive for F4/80 were identified as early as postnatal day 0, and these cells also displayed uptake of microspheres. (biomedcentral.com)
The organ uptake rate of the tracer, and new parameters concerned with the degradative functions of Kupffer cells obtained from analysis of the excretion phase of the hepatic time-uptake rate curve, were measured in rats with two different types of chronic liver damage induced by carbon tetrachloride (fatty liver group and liver cirrhosis group). (elsevier.com)

The Biological Function of Kupffer Cells in Liver Disease, Biology of Myelomonocytic Cells Anirban Ghosh, IntechOpen, DOI: 10.5772/67673. (intechopen.com)
Nobiletin ameliorates ischemia-reperfusion injury by suppressing the function of Kupffer cells after liver transplantation in rats. (hepaton.com)

These changes were suppressed by GdCl 3 treatment prior to T 3 , an agent-eliciting Kupffer-cell depletion, inhibition of colloidal carbon phagocytosis, and the associated respiratory burst activity, with enhancement in nuclear inhibitor of Nrf2 kelch-like ECH-associated protein 1 (Keap1)/Nrf2 content ratios suggesting Nrf2 degradation. (hindawi.com)
Benefit of Kupffer cell modulation with glycine versus Kupffer cell depletion after liver transplantation in the rat: effects on postischemic reperfusion injury, apoptotic cell death graft regeneration and survival. (sigmaaldrich.com)
In conclusion, interruption of TNF-alpha signaling or depletion of Kupffer cells improves survival after 30% liver transplantation, reduces liver injury, and enhances regeneration. (uzh.ch)
The role of Kupffer cells (KCs) was determined by clodronate-liposome (CL)-mediated depletion, and their functional mechanisms were explored by the inhibition of KC efferocytosis via TIM-4 blocking Abs, during the recovery stage of liver IRI (three doses at 24h, day 3 and day5 post reperfusion). (atcmeetingabstracts.com)
Using conditional depletion of liver Kupffer cells, we traced the developmental stages of monocytes differentiating into Kupffer cells and mapped the cellular interactions imprinting the Kupffer cell identity. (researchportal.be)

Kupffer cells/macrophages are classified into two subsets, radio-resistant resident Kupffer cells and radio-sensitive bone marrow-derived Kupffer cells/macrophages (8, 9). (deepdyve.com)
Whereas resident Kupffer cells express F4/80 and CD68 and have high phagocytic activity and reactive oxygen species production, bone marrow-derived Kupffer cells/macrophages express F4/80 and CD11b and produce proinflammatory cytokines efficiently (8). (deepdyve.com)
Thus, activation of the reticuloendothelial system by latex phagocytosis induces the migration of PMNs into the liver and enhances the production of toxic oxygen-derived radicals by these cells and the resident Kupffer cells. (researchwithrutgers.com)

abstract = "Temporal and spatial changes of lipid peroxides in a cultured colon cancer cell line, Colo-205 cells, were investigated after culturing with Kupffer cells by using 2′,7′-dichlorofluorescein diacetate and a digital imaging processor equipped with an inverted microscope. (elsevier.com)
abstract = "Kupffer cell function was assessed by using scintigraphy to evaluate the turnover of a metabolizable tracer (99mTc-millimicrosphered albumin). (elsevier.com)
Ni M, Wang H, Jin D, Zhang J, Busuttil R, Kupiec-Weglinski J, Wang X, Zhai Y. Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis [abstract]. (atcmeetingabstracts.com)

dministration oxidant induced activation of kupffer cells occur, with the release of proinflammatory cytokines like tumor TNF-[alpha], TGF-[beta] and IL-6. (thefreedictionary.com)
In addition, activated Kupffer cells produce and release several mediators including cytokines, lipid substances, and reactive oxygen species (ROS), which can function locally or systemically to mediate immune responses [ 1 ]. (hindawi.com)
Pro-inflammatory cytokines released by activated Kupffer cells, such as TNF-α and IL-6, are associated with up-regulation of acute-phase response proteins and suppression of CYP enzymes. (tebu-bio.com)
galectin-9 also induces anti-inflammatory cytokines from peripheral but not hepatic mononuclear cells. (harvard.edu)
Generally, liver fibrosis begins with the stimulation of inflammatory immune cells to secrete cytokines, growth factors, and other activator molecules. (intechopen.com)
The results showed that sAPS3 effectively ameliorated CCl4 induced hepatocellular necrosis and inflammation and significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, malondialdehyde and the expression levels of Kupffer cells (KCs)-specific biomarker CD68 and proinflammatory cytokines produced by activated KCs such as IL-1β and TNF-α (P (hepaton.com)
Studies possess recorded that Kupffer cell performed a key part in creating the systemic adjustments in host immune system responses, specifically through the up-regulation and launch of proinflammatory cytokines , . (bio2009.org)
We demonstrated that these cells have the potential to respond to cytokines and lipopolysaccharide with an increased production of tumor necrosis factor-α and interleukin-1β. (elsevier.com)

However, inflammatory conditions allow rapid differentiation of monocytes into mature cells that are indistinguishable from genuine KC. (springer.com)
The presence of F4/80 antigen (which becomes expressed as monocytes mature into tissue macrophages) on sinusoidal liver cells has been used to "define" KCs ( 9 ). (frontiersin.org)
Bone marrow derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. (europa.eu)
This suggests that CLEC4F is a C-type lectin with diverse binding specificity expressed on residential Kupffer cells and infiltrating monocytes in the liver, and may play an important role to modulate glycolipids presentation on Kupffer cells. (nih.gov)
Importantly, while a single LPS injection results in similar recruitment of inflammatory monocytes to the liver, the functional properties of the infiltrating cells are dramatically different in response to LPS versus LCMV infection. (elsevier.com)
Strikingly, the gene expression levels of inflammatory monocytes dramatically change upon LCMV exposure and resemble those of Kupffer cells. (elsevier.com)
Since inflammatory monocytes outnumber Kupffer cells 24 h after LCMV infection, it is highly likely that inflammatory monocytes contribute to the intrahepatic inflammatory response during the early phase of infection. (elsevier.com)
Our findings are instrumental in understanding the early immunological events during virus-induced liver disease and point toward inflammatory monocytes as potential target cells for future treatment options in viral hepatitis. (elsevier.com)
monocytes/macrophages are the primary cells of the innate immune system. (mdpi.com)
HMGB1 could be either passively released from necrotic or broken cells, or could be positively secreted by monocytes and macrophages under tense conditions . (bio2009.org)
ED1 is the most widely used monoclonal antibody clone directed against the rat CD68 protein and is used to identify macrophages, Kupffer cells, osteoclasts, monocytes, and activated microglia in rat tissues. (wikipedia.org)

The abilities of KC to activate T cells and to suppress T cell activation induced by spleen dendritic cells (DC) were examined by in vitro proliferation assays using OTII cells. (jimmunol.org)
The cytokine response of isolated Kupffer cells to stimulation with bacterial endotoxin (LPS) in vitro has been characterized by Sekisui XenoTech's scientists (Lambert et al. (tebu-bio.com)
Neoplastic and in vitro cultured cells apart, endothelium cialis over the counter at walmart reviews is the only nonmyofibroblastic cell type to show well-developed fibronexus junctions. (panelstaff.top)
The inclusion of Kupffer cells in in vitro hepatic cultures provides researchers with advanced tools for disease modeling and drug discovery. (fiercebiotech.com)
Kupffer cells (KCs) were activated and co-cultured with different concentration of nobiletin for 24h in vitro, inflammatory products and activity of TLR4/NF-κB signaling pathway were detected. (hepaton.com)
Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. (oregonstate.edu)
Also, after addition of ibuprofen in vitro to isolated cells, there was more than 50% inhibition of O 2 - generation by Kupffer cells and hepatic PMNs treated with either zymosan or PMA. (researchwithrutgers.com)

Kupffer cells, named after Karl Wilhelm von Kupffer (1829-1902), are found in the bloodstream and in the liver, attached to the walls of the sinusoids . (encyclopedia.com)
for a similar period showed dose- and duration-dependant protective effects, such as diminution of fibrosis and fatty changes, while dilated blood sinusoids, vacuolar degeneration and hypertrophy of Kupffer cells were also seen, when compared to the liver sections of rats intoxicated with [CCl. (thefreedictionary.com)
These functional alterations were accompanied by some histological alterations, like congestion of the central vein, some polymorphonuclear inflammatory cells infiltrate, sinusoids walls showing numerous Kupffer cells with swelling lumen by the blood cells (Figure 5). (thefreedictionary.com)
Highly activated Kupffer cells were observed in close contact with tumor cells in sinusoids and also in tumor forming foci within the hepatic parenchyma. (nih.gov)
Kupffer cells and other macrophages were found to leave the sinusoids and migrate to sites of potential tumor development where they interacted with tumor cells and intimately wrapped their processes around fat storing cells. (nih.gov)
Kupffer cells reside in liver sinusoids representing approximately 35% of hepatic nonparenchymal cells. (hindawi.com)
This project aimed to address this gap in our knowledge by generating and applying new methods to study Kupffer cells (KCs), which are not only the most abundant immune cells in the liver but also the first immune cells to be in contact with materials entering the liver from the intestine as they reside in the blood flow in the liver sinusoids. (europa.eu)
Kupffer cells are specialized macrophages lining the walls of the sinusoids in the liver. (cellapplications.com)
Among the different cells in hepatic sinusoids, the nonphagocytic "fat-storing" cells (39) are always peroxidase negative, whereas the lining cells in process of erythrophagocytosis are consistently peroxidase positive. (rupress.org)
In ex vivo study using isolated perfused rat liver, dichlorofluorescin-preloaded cancer cells, which were transportally injected, were found to adhere to hepatic sinusoids and then to enhance their fluorescence. (elsevier.com)
Kupffer cells form a partial lining of the liver sinusoids, acting to phagocytose foreign particulate matter from the circulating blood. (biomedcentral.com)
Finding in the liver organ sinusoids, Kupffer cells (KCs) comprise the biggest human population of tissue-fixed macrophages in the human being organism. (bio2009.org)

Glauhann H. (1976) Phagocytosis and Intralysosomal Digestion of Subcellular Organelles by Kupffer Cells of Rat Liver. (springer.com)
Phagocytosis in Kupffer's star cells of the liver, sec. of mammalian liver injected with trypan blue prepared microscope slide. (inds.co.uk)
Kupffer cells were characterized by: (1) morphologic characteristics after adherence to plastic, (2) staining for α-naphthyl acetate esterase, (3) immunofluorescence with monoclonal antibodies, and (4) phagocytosis of latex beads. (elsevier.com)

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. (thefreedictionary.com)
An electron microscopy study of Kupffer cells in livers of mice having Friend erythroleukemia hepatic metastases. (nih.gov)
We have also developed precise methods to identify and isolate different immune cells which respond to such antigens from mice and men, a process crucial to our better understanding of the specific functions of each of these cell types. (europa.eu)
Oyama T, Miyazaki M, Yoshimura M, Takata T, Ohjimi H, Jimi S. Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence in Mice. (mdpi.com)
Adoptive transfer of wild-type Kupffer cells to Trem1 -deficient mice complemented these defects and reversed unresponsiveness to DEN-induced liver injury and malignant development. (aacrjournals.org)
In this study, we investigated the role of LXRα in the pathogenesis of steatohepatitis by assessing the effects of a high-fat and high-cholesterol diet (HFCD) on hepatic immune cell proportion and function as well as lipid metabolism in wild-type (WT) and LXRα-KO mice. (deepdyve.com)
These mice had higher cholesterol levels in the plasma and the liver and dysregulated expression of LXR target and proinflammatory genes in both whole liver samples and isolated hepatic mononuclear cells. (deepdyve.com)
Flow cytometry showed an increase in CD68+CD11b+ Kupffer cells/macrophages and a decrease in invariant natural killer T cells in the liver of HFCD-fed LXRα-KO mice. (deepdyve.com)
Mice fed a high-cholesterol diet or a high-fat and high-cholesterol diet (HFCD) have increased numbers of CD11b+ Kupffer cells/macrophages in the liver and are highly susceptible to acute hepatic inflammation induced by cytosine-phosphate-guanine oligonucleotide or α-galactosylceramide (α-GalCer) administration (10, 11). (deepdyve.com)
Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice. (dbcls.jp)
We investigated the role of Kupffer cells during CCl(4) intoxication using Nucling-knockout mice (the KO group), in which the number of Kupffer cells is largely reduced. (mysciencework.com)
Kupffer cells isolated from WT and Nogo-B KO mice were assessed for M1 and M2 activation. (elsevier.com)
Conclusion: Nogo-B is permissive of M1 polarization of Kupffer cells, thereby accentuating liver injury in ALD in humans and mice. (elsevier.com)
Kupffer cells are well known macrophages of the liver, however, the developmental characteristics of Kupffer cells in mice are not well understood. (biomedcentral.com)
Although several studies have examined varied aspects of Kupffer cell function in mice, there has not been, to our knowledge, a study of the basic characteristics and the postnatal development of Kupffer cells in mice. (biomedcentral.com)
Because of the important role that will be played by mice in future studies of liver function, it is imperative to establish the baseline of normal Kupffer cell composition to serve as a reference for these future studies. (biomedcentral.com)
The purpose of this study was to identify and characterize Kupffer cells in the livers of postnatal mice, and to determine the age in mice at which Kupffer cells are phagocytically active. (biomedcentral.com)

Bieghs V, Walenbergh SM, Hendrikx T, van Gorp PJ, Verheyen F, Olde Damink SW et al (2013) Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation. (springer.com)
Targeting of markers expressed on KCs and inflamed epithelium offers perspectives for monitoring the inflammation development and understanding the type of specific cells and receptors involved ( 7 ). (frontiersin.org)
On the other hand, type I interferons delay the regeneration of immune cells, which are important to adjust and maintain the immune balance within the liver during acute inflammation. (eurekalert.org)
Together, our findings offer causal evidence that TREM-1 is a pivotal determinant of Kupffer cell activation in liver carcinogenesis, deepening mechanistic insights into how chronic inflammation underpins the development and progression of liver cancer. (aacrjournals.org)
Kupffer primary cells are macrophages endogenous to the liver which have the ability to modulate hepatic inflammation and injury associated with various pathophysiologies and toxicities. (tebu-bio.com)
A number of immune cells, including Kupffer cells, natural killer (NK) cells, and natural killer T (NKT) cells, are present in the liver and participate in the induction and progression of hepatic inflammation (7). (deepdyve.com)
Kupffer cells are tissue-resident macrophages in the liver that play an important role in inflammation associated with infection. (otago.ac.nz)
The studies described in this thesis investigated the potential roles of Kupffer cells on liver and lung injury, inflammation and the systemic inflammatory response in sepsis using gadolinium chloride (GdCl3) to inactivate these cells. (otago.ac.nz)

Because the liver sequesters up to 70% of nanomaterials, in this study, we asked, if liver Kupffer cells were removed, what is the impact on tumor delivery? (pnas.org)
cytokine) called tumor necrosis factor alpha (TNF-[alpha]) from Kupffer cells (Nakamura et al. (thefreedictionary.com)
Kupffer cells, which are part of the reticuloendothelial system, play an important role in clearing pathogenic substances, including tumor cells, from the liver. (nih.gov)
The role of Kupffer cells in tumor development is very important as Kupffer cells can be manipulated to a tumoricidal state with biological response modifiers to kill tumor cells and thus to decrease tumor burden and extend survival time. (nih.gov)
To gain additional information on the role of Kupffer cells and their interaction with tumor cells in hepatic metastases, we studied an established experimental hematogenous metastatic model (Friend erythroleukemia) in mouse livers by light and electron microscopy. (nih.gov)
The Kupffer cells were activated by the presence of the hematogenous tumor cells and were able to lyse and phagocytose them. (nih.gov)
However, some tumor cells evaded the Kupffer cells as metastases still occurred. (nih.gov)
Variation between multidisciplinary tumor boards in clinical staging and treatment recommendations for patients with locally advanced non-small cell lung cancer. (onmedica.com)
In the present study Kupffer cells were isolated from rat livers, cultured for 24 hours and incubated with galactosamine, endotoxin (LPS) or tumor necrosis factor-alpha for 4 or 24 hours. (soton.ac.uk)
The second phase is assumed to start about 8 h subsequent to CCl(4) administration and involves the oxidant-induced activation of Kupffer cells, which release various pro-inflammatory mediators such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). (mysciencework.com)
Without any prior activation, Kupffer cells isolated from an intact rat liver caused rapid increase in the intensity of dichlorofluorescein in tumor cells in a time-dependent manner. (elsevier.com)
Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. (duke.edu)
Kupffer cells cultured with lipopolysaccharide were able to produce interleukin-1β and tumor necrosis factor-α in a time- and dose-dependent fashion and maximal secretion was observed with the use of 10 μg of lipopolysaccharide per milliliter within 8 hours of treatment. (elsevier.com)

Inhibition or destruction of Kupffer cells (KC) may protect against ischemia-reperfusion (IR) induced primary graft nonfunction (PNF) in liver transplantation. (sigmaaldrich.com)
The purpose of this study was to examine whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotxin gut-leakage, the subsequent Kupffer cells (KCs) activation and lipopolysaccharide (LPS) receptors expression. (aspetjournals.org)

This study describes the isolation and characterization of human fetal Kupffer cells. (elsevier.com)
We have demonstrated mature functional activity of human fetal Kupffer cells at an early gestational age (13 to 19 weeks) and discussed the roles that these cells may play in development and protection of the fetus. (elsevier.com)

Compared with the normal liver tissues from the control group, in knockouts following LPS treatment significant evidence of injury with severe sinusoidal vascular congestion, mild neutrophilic infiltration and Kupffer cell activation were demonstrated by some previous researchers (Konyalioglu et al. (thefreedictionary.com)
In 25-40% of sinusoidal cells, an electron-opaque reaction product is localized in segments of the endoplasmic reticulum, including the perinuclear cisternae, a few Golgi vesicles and saccules and in some large membrane-bounded granules. (rupress.org)

The cells were first observed by Karl Wilhelm von Kupffer in 1876. (wikipedia.org)

Kupffer cell activation is responsible for early ethanol-induced liver injury, common in chronic alcoholics. (wikipedia.org)
The second hit is characterized by an activation of the Toll-like receptor 4 (TLR4) and CD14, receptors on the Kupffer cell that internalize endotoxin (lipopolysaccharide or LPS). (wikipedia.org)
Thus, it was hypothesized that Kupffer cell activation by endotoxin derived from intestinal bacteria causes those cells to generate superoxide and TNF-[alpha], both of which can lead to tissue damage in the liver (see figure 1). (thefreedictionary.com)
Activation of in vivo Kupffer cell function by oral administration of Cordyceps sinensis in rats. (thefreedictionary.com)
These findings confirm that the binding of endotoxin to its receptors on the Kupffer cells and the resulting Kupffer cell activation and production of TNF-[alpha] are key events in the development of alcoholic liver injury. (thefreedictionary.com)
Another line of evidence indicates that activation of Kupffer cells is a key component in the outcome of malaria liver stage infection. (frontiersin.org)
This contention is supported by suppression of the respiratory burst activity of Kupffer cells and the associated reactive oxygen species production by GdCl 3 or apocynin given prior to T 3 , thus hindering Nrf2 activation. (hindawi.com)
We hypothesized that KC could induce T cell tolerance by acting as ¡°poor¡± antigen presenting cells, as well as an active suppressor of T cell activation. (jimmunol.org)
Myocardial Infarction primes autoreactive T cells through activation of dendritic cells. (europa.eu)
This work studied the activation of hepatic macrophages during acute pancreatitis and the involvement of these cells in the lung inflammatory response. (csic.es)
Besides KC activation, PNF is characterized by microvascular perfusion failure, intrahepatic leukocyte accumulation, cell death and hepatocellular dysfunction. (sigmaaldrich.com)
Trem1 deficiency attenuated Kupffer cell activation by downregulating transcription and protein expression of interleukin (IL)-6, IL-1β, TNF, CCL2, and CXCL10. (aacrjournals.org)
In addition, Trem1 ablation diminished activation of the p38, extracellular regulated kinase 1/2, JNK, mitogen-activated protein kinase, and NF-κB signaling pathways in Kupffer cells, resulting in diminished liver injury after DEN exposure. (aacrjournals.org)
For new biological entities, particularly immunomodulators, evaluating the potential for Kupffer cell activation is an emerging concept in preclinical development. (tebu-bio.com)
These findings clearly indicate that Kupffer cell activation plays an important role in cold and warm ischemic insult in rat liver. (nii.ac.jp)
The findings provide evidence for activation of bone marrow-derived Kupffer cells/macrophages and dysfunction of invariant natural killer T cells in LXRα-KO mouse liver. (deepdyve.com)
Resident macrophages (Kupffer cells, KCs) in the liver can undergo both pro- or anti-inflammatory activation pathway and exert either beneficiary or detrimental effects on liver metabolism. (biomedcentral.com)
Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion. (dbcls.jp)
Furthermore, Nogo-B-positive Kupffer cells were correlated with M1 activation (inducible nitric oxide synthase) (r = 0.50, P = 0.05) and negatively with markers of M2 status (CD163) (r = −0.48, P = 0.07) in these patients. (elsevier.com)
Moreover, several evidences have suggested that hepatic stem/progenitor cell (HPCs) activation is a component of the adaptive response of the liver to oxidative stress in NAFLD. (mdpi.com)

Histologic evidence suggests two possibilities: a localized impairment of Kupffer cell activity in the area about the central veins of the lobule, or an abnormal circulation through preferential pathways restricted to the periphery of the liver lobule. (ahajournals.org)
The data showed that the impairment of Kupffer cell degradative function occurred even earlier in liver damage than impairment of the phagocytic activity, so that the K value and the D 60 value were the more sensitive indicators of Kupffer cell function. (elsevier.com)

Hepatic CYP protection after a hemorrhage and CO-RBC resuscitation can be attributed to the inactivation of Kupffer cells, resulting in the suppression of ROS production in the early phase and the suppression of inflammatory cytokine production via the TLR-4/HMGB-1signal pathway in the late phase. (elsevier.com)
Inactivation of Kupffer Cells by Selenizing Astragalus Polysaccharides Prevents CCl4-Induced Hepatocellular Necrosis in the Male Wistar Rat. (hepaton.com)
These findings indicate that sAPS3 could ameliorate CCl4-induced hepatocellular necrosis by inactivation of Kupffer cells and its activity may be superior to the application of selenium, APS or combination of selenium with APS. (hepaton.com)

Research funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA)/National Institutes of Health (NIH) first identified the importance of Kupffer cells and their response to endotoxin in the progression of liver disease (Thurman et al. (thefreedictionary.com)
Endotoxin binds to Kupffer cell receptors, initiating a cascade of events that lead to the release of a chemical messenger (i. (thefreedictionary.com)
Kupffer cells (KCs), phagocytic liver-resident macrophages, provide a protective barrier against egress of endotoxin from the portal to the systemic circulation. (bmj.com)
Activated Kupffer cells may release substances that are involved in liver injury induced by galactosamine and endotoxin. (soton.ac.uk)

In earlier work (5,6,8) an experimental model was used in which cellular organelles were introduced to the lysosomal apparatus of Kupffer cells by means of heterophagocytosis. (springer.com)

These results indicated that excess reactions of Kupffer cells, once primed by oxidants, were involved in the exacerbation of oxidative stress and liver damage during the second phase of CCl(4) intoxication. (mysciencework.com)
The present study suggested that the resident Kupffer cell-derived oxidative stress participates in the cytotoxic process against cancer cells by inducing intracellular lipid peroxidation. (elsevier.com)

A significant positive correlation was observed between Nogo-B positive Kupffer cells and disease severity in ALD patients (n = 30, r = 0.66, P = 0.048). (elsevier.com)

In the erythrocytic phase of malaria, Kupffer cells show marked hypertrophy and hyperplasia and are filled with malarial pigment. (austin.org.au)
The aim of the present study was to investigate the effects of administration of gold nanoparticles GNPs on inflammatory cells infiltration, central vein intima disruption, fatty change, and Kupffer cells hyperplasia in the hepatic tissue in an attempt to cover and understand the toxicity and the potential threat of their therapeutic and diagnostic use. (duhnnae.com)
In addition, inflammatory cell infiltration, Kupffer cells hyperplasia, central veins intima disruption, hepatic strands dilatation and occasional fatty change together with a loss of normal architechiture of hepatic strands were also seen. (duhnnae.com)

Electron microscopy showed latex in Kupffer cells, more abundantly seen in high-parasitemic animals.Total Kupffer cell phagocytic activity of the liver is markedly increased in rats with a high parasitemic load of malarial P. berghei infection. (austin.org.au)
The data demonstrated a reduced phagocytic activity of the Kupffer cells in rats with chronic liver injury. (elsevier.com)

KCs express several cell-surface receptors and receptor complexes involved in immune stimulation ( 5 ). (frontiersin.org)
ET-3-induced metabolism of phosphoinositides was inhibited completely in Kupffer cells pretreated with ET-3, suggesting homologous ligand-induced desensitization of the ET-3 receptors. (biochemj.org)

MRSA count was the highest in the liver, especially within Kupffer cells, which were positive for acid polysaccharides that are associated with intracellular biofilm. (mdpi.com)

There they complete their differentiation into Kupffer cells. (wikipedia.org)
BioTime develops and markets research products in the field of stem cells and regenerative medicine, including a wide array of proprietary ACTCellerate™ cell lines, culture media, and differentiation kits. (fiercebiotech.com)
CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g. (wikipedia.org)

Removal of a portion of Kupffer cells ensure host immunity is not significantly suppressed and provides improved pharmacokinetics of gold nanoparticles by preventing off-target accumulation in the liver. (nih.gov)

When Kupffer cells were inhibited, the increase in serum TNF-α levels and the infiltration of neutrophils in the lung were prevented, but P-selectin expression remained unmodified. (csic.es)

Kupffer cells (KC) constitute 80-90% of the tissue macrophages present in the body. (nih.gov)
KC account for approximately 10-15% of the total liver cell population and represent 80-90% of tissue macrophages in the reticuloendothelial system. (bmj.com)

The role of Kupffer cells and reactive oxygen species in hepatic injury during acute and chronic alcohol intoxication. (thefreedictionary.com)
The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. (valorebooks.com)
Although Kupffer cells (KC) have been indicated to play a role in liver tolerance to allografts and soluble antigens, the mechanisms involved remain unclear. (jimmunol.org)
Mesenchymal stem cells (MSCs) have been proposed as a promising therapy for treatment of certain liver diseases, but the role of MSCs in DCD liver graft function remains elusive. (springer.com)
Role of Kupffer cells in the induction of tolerance after liver transplantation. (semanticscholar.org)
The role of Kupffer cells (KC) in the induction of tolerance caused by preoperative donor-specific blood transfusion (DST) was investigated. (semanticscholar.org)
The role of Kupffer cells in carbon tetrachloride intoxication. (mysciencework.com)
It may be sustained that Kupffer cells play a role in the host defence mechanisms against the liver metastasis of colon cancer cells. (elsevier.com)
The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established. (ovid.com)
Although the Fas-FasL system has been widely studied for its role in tissue growth (1) and elimination of malignant (16) and damaged cells (10), its role is perhaps best characterized in the immune system. (nutriforce.cn)
Gaudio, E. Role of Hepatic Progenitor Cells in Nonalcoholic Fatty Liver Disease Development: Cellular Cross-Talks and Molecular Networks. (mdpi.com)

Fibrosis is a wound-healing response that engages a range of cell types and mediators to encapsulate an injury. (biomedcentral.com)

In conclusion, galectin-9 production by Kupffer cells links the innate and adaptive immune response, providing a potential novel immunotherapeutic target in this common viral infection. (harvard.edu)

Total Kupffer cell counts and their composition (M1 vs. M2 Kupffer cells) were measured using flow cytometry with F4/80 and CD206 antibodies. (hanyang.ac.kr)

Primary culture of Rat Kupffer cells is suitable for cell-based assays including toxicity, drug screening and disease modeling, and is a valuable tool to study liver physiology and associated diseases. (cellapplications.com)

identified a receptor present in Kupffer cells, the complement receptor of the immunoglobulin family (CRIg). (wikipedia.org)
In this study, we developed a series of nanobodies by a phage display screening building from lymphocytes isolated from an alpaca immunized with recombinant mouse Kupffer cell receptor Clec4F, which is involved in pathogen recognition by binding to galactose and N-acetylgalactosamine. (frontiersin.org)
Taken together, we developed a series of nanobodies targeting multiple distinct recognition epitopes of the Kupffer cell-specific receptor Clec4F which may be useful for its structural and functional investigation as well as for use as molecular imaging and therapeutic agents. (frontiersin.org)
In fact, recruitment of natural killer T (NKT) cells in sporozoites-infected livers was shown to be dependent on the expression of interferon-alpha/beta receptor alpha chain ( 5 ). (frontiersin.org)
Here we show that expression of the proinflammatory myeloid cell surface receptor TREM-1 expressed by Kupffer cells is a crucial factor in the development and progression of liver cancer. (aacrjournals.org)
The LT-β ligand and receptor were expressed by isolated normal Kupffer cells. (edu.au)

We previously reported that gadolinium chloride (GdCl), an agent that depletes the liver of phagocytically active Kupffer cells, enhances hepatic expression of TNF messenger RNA (mRNA) and promotes liver regeneration after subsequent PH. (wiley.com)

This suggests that GdCl interferes with Kupffer cell mechanisms that normally constrain TNF production after PH. (wiley.com)
In the early phase (∼1 h) after a hemorrhage and RBC resuscitation, hepatic CYP protein levels were significantly decreased with increasing hepatic free heme levels, but were maintained by a pre-treatment of gadolinium chloride (GdCl 3 ), a Kupffer cell inhibitor, and Trolox, an anti-oxidant agent, as well as CO-RBC resuscitation. (elsevier.com)
Methods: Sprague-Dawley rats were divided into two groups: one group received a single dose of GdCl (a Kupffer cell-blocking agent, 10 mg/kg i.v.), whereas the other group received saline. (edu.au)
Pretreatment of bile duct-ligated animals with GdCl significantly reduced the number of Kupffer cells, delayed the rise in LT-β expression, but had no effect on fibrogenesis. (edu.au)

We have investigated the effect of Kupffer cell blockade GdCl3 on liver function in warm ischemic model in rats. (nii.ac.jp)
Austin Health Research Online: Hepatic Kupffer cell phagocytotic function in rats with erythrocytic-stage malaria. (austin.org.au)
Hepatic Kupffer cell phagocytotic function in rats with erythrocytic-stage malaria. (austin.org.au)

However, profound prevention of intrahepatic cell death and liver graft failure was solely achieved with glycine preconditioning. (sigmaaldrich.com)
Glycine appears to preserve cell viability and to TNFalpha/leukocyte dependent organ regeneration capacity, which is related to increase graft survival following liver transplantation. (sigmaaldrich.com)

Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF et al (2003) Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. (springer.com)
XenoTech offers Kupffer cells to aid in the assessment of cytokine release by biologics and small molecule drugs. (tebu-bio.com)
Kupffer cells (KCs) were a substantial way to obtain cytokine release through the early stage of serious burns. (bio2009.org)

The significance of these observations in respect to some recent studies suggesting localization of exogenous peroxidases in the endoplasmic reticulum of Kupffer cells and peritoneal macrophages (22, 23) is briefly discussed. (rupress.org)

Here, we demonstrate that galectin-9, the natural ligand for the T cell immunoglobulin domain and mucin domain protein 3 (Tim-3), circulates at very high levels in the serum and its hepatic expression (particularly on Kupffer cells) is significantly increased in patients with chronic HCV as compared to normal controls. (harvard.edu)

In contrast to F4/80, CLEC4F is detectable in fetal livers at embryonic day 11.5 (E11.5) but not in yolk sac, suggesting the expression of CLEC4F is induced as cells migrate from yolk cells to the liver. (nih.gov)
Furthermore, confocal microscopy of liver macrophages revealed efferocytotic (>2 DAPI positive nucleuses) F4/80 positive cells isolated from ischemic livers at day 3 and 5, but not 6h or sham, post reperfusion. (atcmeetingabstracts.com)

To understand the local immune responses, they analyzed Kupffer cells, which are liver-resident scavenger cells within the immune system. (eurekalert.org)

Rat Kupffer cells from Cell Applications, Inc. provide an excellent model system to study many aspects of human liver function, metabolism and pathophysiology. (cellapplications.com)
Endothelin-3 (ET-3) stimulated phosphoinositide metabolism and synthesis of prostaglandins in cultured rat Kupffer cells. (biochemj.org)
Upon challenging Kupffer cells with both ET-3 and PAF, an additive stimulation of phosphoinositide metabolism was observed, suggesting that the actions of these factors may be exerted on separate phosphoinositide pools. (biochemj.org)
The present results suggest that the stimulatory effects of ET-3 and PAF on the phosphodiesteric metabolism of phosphoinositides in Kupffer cells require different guanine-nucleotide-binding proteins. (biochemj.org)
Thus, dysregulation of lipid metabolism, specifically cholesterol accumulation, activates hepatic immune cells and induces hepatic inflammatory diseases including NASH. (deepdyve.com)
The metabolism of L-arginine by activated Mφ to substances with cytostatic and even lethal effects on target cells is a relatively recent discovery. (rupress.org)

The identification of tissue-resident macrophages and their unique feature in relation to other immune cells has so far mainly relied upon the detection of their anatomical position ( 2 , 3 ). (frontiersin.org)
Kupffer cells filter bacteria and other foreign proteins from the blood and initiate immune responses. (thefreedictionary.com)
Type I interferons, on the one hand, limit viral replication and thereby help the immune cells to control the viral pathogen. (eurekalert.org)
We verified that therapeutic treatment of acute viral hepatitis with type I interferon is reasonable, since it activates local immune cells and helps to eliminate the virus," concludes institute director Prof. Ulrich Kalinke. (eurekalert.org)
We also aimed to assess how KCs influence the other immune cells involved in instructing immune responses to such agents. (europa.eu)
The possible pathophysiological roles of hepatic immune cells, such as the two subsets of Kupffer cells/macrophages, in NAFLD/NASH induced by dietary cholesterol overload remain largely unknown. (deepdyve.com)
MSCs exert powerful immunosuppressive functions via paracrine effects and cell-cell contact-dependent interactions, and MSCs also inhibit the proliferation of activated lymphocytes, thereby providing survival signals to resting immune cells and subsequently stimulating the induction of regulatory immune cells [ 12 ]. (biomedcentral.com)
However, in some cell types it is detectable only when up-regulated, such as activated but not quiescent microglia, and can thus be used as a marker of inflammatory conditions and immune reactions in those instances. (wikipedia.org)

C) Coexpression of CLEC4F and F4/80 on Kupffer cells, but not peritoneal macrophages. (nih.gov)

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Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. (1/1142)

Effects of Ro 31-8220 on lipopolysaccharides-induced hepatotoxicity and release of tumor necrosis factor from rat Kupffer cells. (2/1142)

Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (3/1142)

Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. (4/1142)

Intravenous glycine improves survival in rat liver transplantation. (5/1142)

A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: implications for clinical efficacy in treatment of Gaucher disease. (6/1142)

Infection of primary cultures of human Kupffer cells by Dengue virus: no viral progeny synthesis, but cytokine production is evident. (7/1142)

Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide. (8/1142)

No data available that match "kupffer cells"

Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. (1/1142)

Effects of Ro 31-8220 on lipopolysaccharides-induced hepatotoxicity and release of tumor necrosis factor from rat Kupffer cells. (2/1142)

Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (3/1142)

Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. (4/1142)

Intravenous glycine improves survival in rat liver transplantation. (5/1142)

A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: implications for clinical efficacy in treatment of Gaucher disease. (6/1142)

Infection of primary cultures of human Kupffer cells by Dengue virus: no viral progeny synthesis, but cytokine production is evident. (7/1142)

Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide. (8/1142)

The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma<...

Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage...

Cd18/ICAM-1-dependent oxidafive NF-κB activation leading to nitric oxide production in rat Kupffer cells cocultured with...

Kupffer cell activation and portal hypertension | Gut

Uncultured Kupffer Cell Starter Kit | ax3758 (1 kit) | Axol Bioscience

Role of Hepatic Kupffer Cells in Inducing T cell Tolerance (128.12) | The Journal of Immunology

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JCI - Liver inflammation and fibrosis

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Stiftung Forschung 3R / 3R Info Bulletins / Immune cells in the liver : The generation and use of a mouse Kupffer cell line

CD72 Antibody, anti-human, REAfinity™ - Recombinant antibodies - MACS Antibodies - Products - Miltenyi Biotec - Canada

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Distinct patterns of nitric oxide production in hepatic macrophages and endothelial cells following acute exposure of rats to...

Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor...

Kupffer Cells in Health and Disease | SpringerLink

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro | Journal of...

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver...

canine Kupffer cell IHC

JCI - Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

Effect of removing Kupffer cells on nanoparticle tumor delivery. - PubMed - NCBI

Understanding the Liver - Chrysalis Natural Medicine Clinic

Origin and kinetics of Kupffer cells during an acute inflammatory response

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice<...

Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver

SIU SOM Histology GI

KAKEN - Research Projects | Boneficial Effect of Kupffer cell blochade on Preservation Liver Enjury (KAKENHI-PROJECT-07671311)

Stiftung Forschung 3R / Projekte / 3R-Project 63-97

Recent Articles | Kupffer Cells And Immunology | The Scientist Magazine®

Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm. | Sigma...

Cryopreserved Human hepatic sinusoidal endothelial Cells

nanoparticle-based electrochemical Buy Eriacta in Erie problem with

Production Schedule - InSphero

Liver Tissue Model Kit

CD11b αM Integrin (OX-42) | ALZFORUM

Tumor necrosis factor-α and interleukin-1β production by human fetal Kupffer cells<...

Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis -...

JCI - Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

JCI - Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Effect of Hemorrhagic Shock on the Phagocytic Function of Kupffer Cells | Circulation Research

Impaired hepatic bacterial clearance is reversed by surgical relief of obstructive jaundice<...

Estrogen and Liver Toxicity

Effect of removing Kupffer cells on nanoparticle tumor delivery | PNAS

Munin: Liver sinusoidal endothelial cells represents an important blood clearance system in pigs

Untitled Document

Immune Cell Identity Crisis: What Makes a Liver Macrophage a Liver Macrophage?

AODTU-007 Mertk expressing hepatic macrophages promote the resolution of inflammation in acute liver failure | Gut

KAKEN - Research Projects | A MECHANISM OF INFILTRATION OF POLYMORPHONUCLEAR CELLS AND KUPFFER CELLS IN ALCOHOLIC LIVER INJURY ...

Hepatitis therapy: Kupffer cells adjust the balance between pathogen control and hepatocyte regeneration | EurekAlert! Science...

Expression and regulation of leukotriene-synthesis enzymes in rat liver cells<...

Liver function tests - Hcamat College Park

Interaction of liposomes with hepatocytes and Kupffer cells in vivo and in vitro | Biochemical Society Transactions

Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy. |...

"Effect of Carcinoembryonic Antigen Production by Colorectal Cancer Cel" by Olga Bajenova, I. Evsyukov et al.

infectomics-study-of-human-liver-non-parenchymal-c | bfm.hr

infectomics-study-of-human-liver-non-parenchymal-c | bfm.hr

JCI - No recovery of replication-competent HIV-1 from human liver macrophages

Haemolysis and liver macrophages | Nature Reviews Gastroenterology & Hepatology

TEM of Liver Section - Stock Image C025/2732 - Science Photo Library

The Liver & Detoxification (Part 1) - Stay Strong

Plus it

Plus it

Algeoppblomstring i vann - FHI

CD68

Hepatocyte

Frenkelia

Liver cytology

Tadeusz Browicz

CYP3A

Complement receptor 1

Complement system