Models, Biological
Hydrogen-Ion Concentration
Mathematics
Temperature
Models, Chemical
Thermodynamics
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Protein Binding
Binding Sites
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Photoaffinity Labels
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Endoscopes
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Cells, Cultured
Models, Molecular
Amino Acid Sequence
Substrate Specificity
Biological Transport
Ion Channel Gating
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
Mutation
Adenosine Triphosphate
Computer Simulation
Patch-Clamp Techniques
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Rabbits
Metabolic Clearance Rate
Spectrophotometry
Cattle
Catalysis
Dose-Response Relationship, Drug
Diffusion
Models, Theoretical
Cell Membrane
Electrophysiology
Liver
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Base Sequence
Fluorescence
Oxygen
Ion Channels
Fluorescent Dyes
Magnesium
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Oxygen Consumption
Protein Denaturation
Sodium
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Osmolar Concentration
Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Structure-Activity Relationship
Potassium Channels
Deuterium
Biological Transport, Active
Mutagenesis, Site-Directed
Enzymes
Chromatography, High Pressure Liquid
Binding, Competitive
Urea
Myocardium
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Glucose
Carbon Monoxide
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
Carbon Isotopes
Muscle, Skeletal
Water
Myotonia Congenita
Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulation and other movements. It is classified as Thomsen (autosomal dominant) or Becker (autosomal recessive) generalized myotonia mainly based on the inheritance pattern. Becker type is also clinically more severe. An autosomal dominant variant with milder symptoms and later onset is known as myotonia levior. Mutations in the voltage-dependent skeletal muscle chloride channel are associated with the disorders.
Enzyme Activation
Oocytes
Adenosine Diphosphate
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Sodium Channels
Cell Division
Nucleic Acid Renaturation
Surface Plasmon Resonance
A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.
Hepatitis, Infectious Canine
Electron Transport
Cricetinae
Adsorption
Spectrum Analysis
Protons
Solubility
Retinal Dysplasia
Magnetic Resonance Spectroscopy
Carrier Proteins
Amino Acids
Virus Replication
Action Potentials
Algorithms
Rats, Sprague-Dawley
Solutions
Allosteric Regulation
Circular Dichroism
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Phosphorylation
Transfection
Microscopy, Fluorescence
Phenylalanine
Protein Structure, Secondary
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Crustacea
Calcium Channels
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Buffers
Microsomes, Liver
Polymers
Electrophoresis, Polyacrylamide Gel
Transcription, Genetic
Dogs
Neurons
Recombinant Fusion Proteins
Isomerism
Enzyme Inhibitors
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Radioisotope Dilution Technique
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Fluorescence Resonance Energy Transfer
Encephalitis, Varicella Zoster
Inflammation of brain tissue caused by infection with the varicella-zoster virus (HERPESVIRUS 3, HUMAN). This condition is associated with immunocompromised states, including the ACQUIRED IMMUNODEFICIENCY SYNDROME. Pathologically, the virus tends to induce a vasculopathy and infect oligodendrocytes and ependymal cells, leading to CEREBRAL INFARCTION, multifocal regions of demyelination, and periventricular necrosis. Manifestations of varicella encephalitis usually occur 5-7 days after onset of HERPES ZOSTER and include HEADACHE; VOMITING; lethargy; focal neurologic deficits; FEVER; and COMA. (From Joynt, Clinical Neurology, 1996, Ch 26, pp29-32; Hum Pathol 1996 Sep;27(9):927-38)
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Molecular Structure
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Membrane Proteins
Stereoisomerism
Hydrogen
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
Energy Transfer
The transfer of energy of a given form among different scales of motion. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed). It includes the transfer of kinetic energy and the transfer of chemical energy. The transfer of chemical energy from one molecule to another depends on proximity of molecules so it is often used as in techniques to measure distance such as the use of FORSTER RESONANCE ENERGY TRANSFER.
Interleukin-12 Receptor beta 1 Subunit
Liposomes
Rats, Inbred Strains
Heme
Potassium Channels, Voltage-Gated
Kidney
Iodine Radioisotopes
NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Quaternary Ammonium Compounds
Nucleic Acid Conformation
Hemoglobins
Electrochemistry
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Biochemistry
Horses
Peptide Fragments
Xenopus
CHO Cells
Rats, Wistar
The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs. (1/127079)
The disposition kinetics of sulphadimethoxine were studied in six normal beagle dogs after intravenous injection of a single dose (55 mg/kg). The median (range) distribution and elimination half times of the drug were 2.36 (2.06-3.35) hours and 13.10 (9.71-16.50) hours, respectively. Total body clearance of the drug had a median value of 21.7 ml/kg/h and a mean value of 21.4 ml/kg/h. While the overall tissue to plasma level ratio (k12/k21) of the drug was 0.55 after distribution equilibrium had been attained, analogue computer simulated curves showed that at 24 hours the fractions (percentage) of the dose in the central and tissue compartments were 12 and 11%, respectively. The drug was shown, by equilibrium dialysis method, to be highly bound to plasma proteins (greater than 75%) within the usual therapeutic range (50 to 150 mug/ml) of plasma levels. The systemic availability of sulphadimethoxine from the oral suspension was 32.8% (22.5-80.0). Since the absorption half time, 1.87 (0.86-3.22) hours, was considerably shorter than the half-life, 13.10 (9.71-16.50) hours, of the drug, the rate of absorption would have little influence on the dosage regimen. Based on the experimental data obtained, a satisfactory dosage regimen might consist of a priming dose of 55 mg/kg by the intravenous route and maintenance doses of either 27.5 mg/kg of sulphadimethoxine injection given intravenously or 55 mg/kg of the oral suspension administered at 24 hour intervals. The adequacy and duration of therapy will depend upon the clinical response obtained. (+info)Serum ampicillin levels in the calf: influence of dosage, route of administration and dosage form. (2/127079)
Holstein bull calves received ampicillin sodium by the intravenous, intramuscular and subcutaneous routes and ampicillin trihydrate by the intramuscular route, at a dosage of 5 mg/kg. In addition ampicillin sodium and ampicillin trihydrate were given at a 12 mg/kg dosage intramuscularly. The serum ampicillin concentrations were determined at five, 30, 60, 120, 180, 240 and 300 min after drug administration and at 360 min after ampicillin trihydrate injection. Intravenous administration gave a high initial level (16.2 mug/ml) at five min that declined to below 1 mug/ml by 120 min. Subcutaneous administration produced the lowest initial levels of drug but concentrations of drug detected did not differ significantly from the intramuscular administration at any sampling interval. The 12 mg/kg intramuscular ampicillin sodium dosage produced significantly higher levels than the 5 mg/kg dosage only at five min. Ampicillin trihydrate gave higher levels than ampicillin sodium at all times except 30 min (5 mg/kg) and five min (12 mg/kg). The serum ampicillin disappearance study (5 mg/kg intravenous) gave a two component bi-exponential curve. Kinetic analysis of the first component showed a C01 (theoretical initial conc) of 44.8 mug/ml, a ke1 (rate constant of disappearance) of 0.064 mug min and a t1/21 (calculated half-life) of 10.8 min. The Co2, ke2 and t1/22 of the second component were 6.2 mug/ml, 0.0157 mug/min and 46.2 min respectively. (+info)Specific receptors for glucocorticoid in the cytoplasm of the liver of AH 130 tumor-bearing rats. (3/127079)
Specific receptors for dexamethasone (11beta, 17alpha, 21-trihydroxy-9alpha-fluoro-16alpha-methyl-1,4-pregnadiene-3,20-dione) in the cytoplasm of the liver from AH 130 (solid type) tumor-bearing rats markedly increased in the advanced stage of tumor growth. The cytoplasmic receptors of the livers of normal and tumor-bearing rats differed in their affinities for dexamethasone, and their apparent equilibrium (dissociation) constants (K) for dexamethasone were 4.0 and 2.6 X 10(-9) M, respectively. The rates of dissociation of dexamethasone-receptor complexes and the heat denaturations of the receptors in the livers of normal and tumor-bearing rats were similar. The glucocorticoid receptors of tumor-bearing rat liver had slightly higher affinities than did those of normal liver for all the steroids tested. Only a trace amount of receptors for dexamethasone could be detected in the cytoplasm of AH 130 ascites cells. (+info)An investigation into the binding of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to DNA in vitro. (4/127079)
After metabolic activation the carcinogen 15,16-dihydro-11-[3H]methylcyclopenta[a]phenanthren-17-one binds to DNA in vitro, and this binding is prevented by 7,8-benzoflavone. Radioactivity cannot be removed from the DNA with organic solvents or by chromatography on Sephadex G-50, even after heat denaturation of the DNA. Enzymatic hydrolysis yields radioactive fractions, which elute from a column of Sephadex LH-20 immediately after the natural nucleosides. At least two species of reactive metabolites are involved in this bending, those with a half-life of a few hr and others with greater stability. After extraction from the aqueous incubation mixture, they could be detected in discrete polar fractions from separations of the complex metabolite mixture by high-pressure liquid chromatography. Their ability to bind to DNA decreased with time at ambient temperature, and they were rapidly deactivated by acid. 7,8-Benzolflavone acted by suppressing the formation of polar metabolites derived from enzymatic oxidation of the aromatic double bonds. The inhibitor had no effect on the enzymes hydroxylating saturated carbon; hence it is unlikely that metabolism of the methyl group is important in conversion of this carcinogen to its proximate form, although the presence of the 11-methyl group is essential for carcinogenic activity in this series. (+info)Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (5/127079)
The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties. (+info)Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets. (6/127079)
A long-acting thymidine pellet consisting of 190 mg of cholesterol and 60 mg of thymidine has been developed for the study of thymidine metabolism and reutilization in vivo. Implantation of such a pellet s.c. in adult mice will maintain the blood plasma concentration of thymidine at levels between 40 and 8 X 10(-6) M, which are from 36 to 7 times those of normal mice, for periods up to 48 hr. During this period, in vivo uptake and reutilization of [125I]iododeoxyuridine, a thymidine analog, into intestinal and tumor DNA were almost completely suppressed. While iododeoxyuridine reutilization is not large in normal proliferative tissue even in the absence of pellet implants, reutilization of over 30% was measured in large, rapidly growing ascites tumors. The inhibition of iododeoxyuridine incorporation by elevated thymidine blood levels is directly proportional to serum concentration. This appears to be due to a thymidine pool in rapid equilibrium with blood thymidine. This pool is at least 10 times larger than the 4-nmole pool of extracellular thymidine. (+info)The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. (7/127079)
Glucocorticoids, at physiological concentration, inhibit cell division and thymidine incorporation in three lines of human breast cancer maintained in long-term tissue culture. At steroid concentrations sufficient to inhibit thymidine incorporation 50%, little or no effect is seen on protein synthesis 48 hr after hormone addition. All three of these lines are shown to have glucocorticoid receptors demonstrable by competitive protein binding assays. Receptors are extensively characterized in one line by sucrose density gradient analysis and binding specificity studies. Good correlation between receptor-binding specificity and biological activity is found except for progesterone, which binds to glucocorticoid receptor but is noninhibitory. Cross-competition and quantification studies demonstrate a separate receptor for progesterone. This receptor has limited binding specificities restricted largely to progestational agents, whereas the glucocorticoid receptor bound both glucocorticoids and progesterone. Two other human breast cancer lines neither contain glucocorticoid receptor nor are inhibited by glucocorticoids. It is concluded that in some cases glucocorticoids can directly limit growth in human breast cancer in vitro without requiring alterations in other trophic hormones. (+info)Effect of hepatocarcinogens on the binding of glucocorticoid-receptor complex in rat liver nuclei. (8/127079)
The effects of a number of carcinogens and hepatotoxins on the binding kinetics of the interactions of glucocorticoidcytosol receptor complex with nuclear acceptor sites in rat liver were investigated. Both the apparent sites in rat liver were investigated. Both the apparent concentration of nuclear binding sites and the Kd were significantly diminished following treatment of rats with sublethal doses of the carcinogens aflatoxin B1, diethylnitrosamine, dimethylnitrosamine, thioacetamide, 3'-methyl-4-dimethylaminoazobenzene, 4-dimethylaminoazobenzene, and 3-methylcholanthrene. Treatment with actinomycin D resulted in a slight reduction in the apparent concentration of nuclear acceptor sites but had no effect on the nuclear binding Kd. The hepatotoxic but noncarcinogenic analgesic, acetaminophen, as well as the weakly toxic aflatoxin B1 cognate, aflatoxin B2, were without effect on the kinetics or binding capacity of glucocorticoid-nuclear acceptor site interaction. These experiments suggest that chemically induced alteration of functional glucocorticoid binding sites on chromatin may be involved in the biochemical effects produced in liver by carcinogens of several chemical types. This experimental model may provide a useful approach for further elucidation of early events in carcinogenesis. (+info)
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Hydrogen Evolution Reaction Kinetics on Electrodeposited Pt-M (M = Ir, Ru, Rh, and Ni) Cathodes for Ammonia Electrolysis<...
Blood and Urinary 18F Pharmaco kinetics Following Parenteral Administration in the Rat<...
Plus it
NhaA Na+/H+ Antiporter Mutants That Hardly React to the Membrane Potential
Top 10 Health Benefits of Ping Pong/Table Tennis - PickProper
Quantifying the relative contributions of different solute carriers to aggregate substrate transport | The Interface Group
Nonlinear regression analysis - CurveFitter latest version
Gorbatyuk, Mol Vis 2005; 11:648-656. Figure 1.
SONOSTAR Ventilator/Anesthesia SV-100S Medical Ventilator for sale - Other Products manufacturer from china (103129184).
The mechanism of CO2 reduction over Pd/Al2O3: a combined steady state isotope transient kinetic analysis (SSITKA) and operando...
Central Library, KUET catalog › Details for: Thermodynamics, kinetic theory, and statistical thermodynamics /
Protein reaction kinetics in a room-temperature glass | Science
Yan Guo | Division of Applied Mathematics
Kinetic theory of gases - Wikipedia
AID 28475 - Hydrolytic parameter (K) was calculated at pH 7.4 in 0.1 M phosphate buffer (25 degrees Celsius) - PubChem
Plus it
Determination and integration of abundance, processing efficiency, and degradation kinetics of the mRNAs encoding all T. brucei...
Molecular activity of Na+/K+-ATPase from different sources is related to the packing of membrane lipids | Journal of...
An Introduction to the Kinetic Theory of Gases and Magnetoplasmas - L. C. Woods - Oxford University Press
Dissecting protein reaction dynamics in living cells by fluorescence recovery after photobleaching. - Immunology
From the kinetic theory of active particles to the modeling of social behaviors and politics, Quality & Quantity | 10.1007...
Crystallization kinetics in liquid crystals with hexagonal precursor phases by calorimetry
- Manipal Academy of Higher...
A Kinetics Study Of Selected Filtration Media For Nutrient Removal At by Elizabeth Henderson
Allosteric cofactor-mediated enzyme cooperativity: a theoretical treatment | PNAS
Static fatigue
Kinetics[edit]. The strength vs. temperature plot of glass exposed in air is displayed in Figure 2.[6] For different exposure ...
Precipitation hardening
Kinetics versus thermodynamics[edit]. This technique exploits the phenomenon of supersaturation, and involves careful balancing ...
Reaction mechanism
Chemical kinetics[edit]. Information about the mechanism of a reaction is often provided by the use of chemical kinetics to ... Moore J.W. and Pearson R.G. Kinetics and Mechanism (3rd ed., John Wiley 1981) p.276-8 ISBN 0-471-03558-0 ... The kinetics (relative rates of the reaction steps and the rate equation for the overall reaction) are explained in terms of ... Espenson, James H. Chemical Kinetics and Reaction Mechanisms (2nd ed., McGraw-Hill, 2002) chap.6, Deduction of Reaction ...
Photosynthesis
Implications for the determination of Rubisco enzyme kinetics and for limitations to photosynthesis in vivo". Plant Physiology ... Order and kinetics. The overall process of photosynthesis takes place in four stages:[13] ... Implications for the determination of Rubisco enzyme kinetics and for limitations to photosynthesis in vivo". Plant Physiology ...
Gait analysis
Champaign IL:Human Kinetics Pubs.. *^ Best, Russell; Begg, Rezaul (2006). "Overview of Movement Analysis and Gait Features". In ... This use of kinetics, however, does not result in information for individual muscles but muscle groups, such as the extensor or ... Kinetics[edit]. Is the study of the forces involved in the production of movements. ... To calculate the kinetics of gait patterns, most labs have floor-mounted load transducers, also known as force platforms, which ...
Materials science
Kinetics[edit]. Main article: Chemical kinetics. Chemical kinetics is the study of the rates at which systems that are out of ... Kinetics is essential in processing of materials because, among other things, it details how the microstructure changes with ... Diffusion is important in the study of kinetics as this is the most common mechanism by which materials undergo change. ... These characteristics, taken together and related through the laws of thermodynamics and kinetics, govern a material's ...
Epidermis
Cellular kinetics[edit]. Cell division[edit]. As a stratified squamous epithelium, the epidermis is maintained by cell division ...
Axial compressor
Kinetics and energy equations[edit]. Velocity triangle of the swirling fluid entering and exiting the rotor blade ...
Cisapride
Kinetics[edit]. Oral bioavailability of cisapride is approximately 33%. It is inactivated primarily by hepatic metabolism by ...
Chemical reaction
Kinetics. The speed at which reactions takes place is studied by reaction kinetics. The rate depends on various parameters, ...
Anton Geesink
Human Kinetics. p. 7. ISBN 073605099X. .. *^ Anton Geesink. sports-reference.com *^ Anton Geesink. IMDb ...
Outrigger ski
Human Kinetics. ISBN 978-0-7360-3684-9. Retrieved 13 October 2012.. ...
Fletching
Topic "Arrows" in "Archery Fundamentals". Human Kinetics ISBN 0-7360-5501-0 ...
Franjo Mihalić
Human Kinetics. ISBN 0-88011-969-1.. *. Johnson, Richard A.; Johnson, Robert Hamilton (2009). The Boston Marathon. Arcadia ...
Mitsuyo Maeda
Human Kinetics. ISBN 0-7360-4404-3. .. *^ Tani, Yukio; Koizumi, Gunji (1906). The Game of Jiujutsu. Hazell, Watson, Viney LD.. ...
Reaction rate constant
"Chemical Kinetics Notes". www.chem.arizona.edu. Retrieved 5 May 2018.. *^ Blauch, David. "Differential Rate Laws". Chemical ... In chemical kinetics a reaction rate constant or reaction rate coefficient, k, quantifies the rate of a chemical reaction.[1] ... Kinetics.. *^ a b Daru, János; Stirling, András (2014). "Divided Saddle Theory: A New Idea for Rate Constant Calculation". J. ... "Extending molecular dynamics time scales with milestoning: Example of complex kinetics in a solvated peptide". The Journal of ...
Panathenaic Stadium
Human Kinetics. pp. 7-8. ISBN 0-88011-969-1. OCLC 42823784.. ...
Ladder tournament
Human Kinetics. ISBN 978-0-7360-3454-8.. *. Byl, John (2006). Organizing successful tournaments (3rd ed.). Human Kinetics. ISBN ...
Table tennis
Human Kinetics Publishers, Inc. p. 10. ISBN 0-87322-403-5. .. *^ a b Hodges, Larry. "Playing the Seemiller or American Grip". ... Human Kinetics. ISBN 0-87322-403-5. .. *. International Table Tennis Federation (2011). ITTF Handbook 2011/2012. Archived from ...
Jmol
... is computer software for molecular modelling chemical structures in 3-dimensions.[2] Jmol returns a 3D representation of a molecule that may be used as a teaching tool,[3] or for research e.g., in chemistry and biochemistry. It is written in the programming language Java, so it can run on the operating systems Windows, macOS, Linux, and Unix, if Java is installed. It is free and open-source software released under a GNU Lesser General Public License (LGPL) version 2.0. A standalone application and a software development kit (SDK) exist that can be integrated into other Java applications, such as Bioclipse and Taverna. A popular feature is an applet that can be integrated into web pages to display molecules in a variety of ways. For example, molecules can be displayed as ball-and-stick models, space-filling models, ribbon diagrams, etc.[4] Jmol supports a wide range of chemical file formats, including Protein Data Bank (pdb), Crystallographic Information File (cif), MDL Molfile (mol), and ...
Rugby union positions
Human Kinetics.. *. Bompa, Tudor; Claro, Frederick (2008). Periodization in Rugby. Meyer and Meyer Sport.. ...
Bharatanatyam
Human Kinetics. pp. 450-452. ISBN 978-0-7360-5188-0. .. *^ Meduri, Avanthi (1988). "Bharatha Natyam-What Are You?". Asian ...
Maha Shivaratri
Human Kinetics. p. 450. ISBN 978-0-7360-5188-0.. *^ Shobita Punja (1999). Khajuraho: the first thousand years. Penguin Books. ...
BKChem
The topic of this article may not meet Wikipedia's notability guidelines for products and services. Please help to establish notability by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be established, the article is likely to be merged, redirected, or deleted ...
Women in dance
Human Kinetics. pp. 113-. ISBN 978-0-7360-6035-6. .. *^ "La Danseuse : Evolution et Révolution: Les années 1700 à 1750: Les ...
rDock
The development of rDock started in 1998 in RiboTargets (later Vernalis (R&D) Ltd).[1] The software was originally called RiboDock.[2] The development went on until 2006 when the software was licensed to University of York for academic distribution and also maintenance. Six years later, in 2012, Vernalis and University of York decided to release rDock as open-source software to allow its further development by the wider community. The version that was released as open source is developed and supported by University of Barcelona on SourceForge.[3] The development on SourceForge stalled after June 2014.[4] A fork named RxDock is continuing the development of rDock since April 2019 on GitLab.[5][6] ...
Jujutsu
Human Kinetics. p. viii. ISBN 0-7360-5099-X. .. .mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation ...
Myocyte
Human Kinetics. ISBN 978-0-7360-4517-9.. *^ a b Smerdu, V; Karsch-Mizrachi, I; Campione, M; Leinwand, L; Schiaffino, S (Dec ...
Billy Ripken
Human Kinetics. p. 264. ISBN 9780736067829.. *^ "Cal Ripken, Jr., Baseball's Iron Man, to Speak at Kent State Tuscarawas". Kent ...
MODELLER
... , often stylized as MODELLER, is a computer program used for homology modeling to produce models of protein tertiary structures and quaternary structures (rarer).[1][2] It implements a method inspired by nuclear magnetic resonance spectroscopy of proteins (protein NMR), termed satisfaction of spatial restraints, by which a set of geometrical criteria are used to create a probability density function for the location of each atom in the protein. The method relies on an input sequence alignment between the target amino acid sequence to be modeled and a template protein which structure has been solved. The program also incorporates limited functions for ab initio structure prediction of loop regions of proteins, which are often highly variable even among homologous proteins and thus difficult to predict by homology modeling. Modeller was originally written and is currently maintained by Andrej Sali at the University of California, San Francisco.[3] It runs on the operating systems Unix, ...
Michaelis-Menten kinetics - Wikipedia
first-order kinetics).[6] However at higher [. S. ]. {\displaystyle {\ce {[S]}}}. with [. S. ]. ≫. K. M. {\displaystyle [{\ce { ... zero-order kinetics)[6] and asymptotically approaches its maximum rate V. max. =. k. cat. [. E. ]. 0. {\displaystyle V_{\max }= ... In biochemistry, Michaelis-Menten kinetics is one of the best-known models of enzyme kinetics. It is named after German ... Michaelis-Menten kinetics have also been applied to a variety of spheres outside of biochemical reactions,[5] including ...
Kinetics | dynamics | Britannica.com
Authors using the term kinetics apply the nearly synonymous name dynamics (q.v.) to the classical mechanics of moving bodies. ... Kinetics, branch of classical mechanics that concerns the effect of forces and torques on the motion of bodies having mass. ... Kinetics, branch of classical mechanics that concerns the effect of forces and torques on the motion of bodies having mass. ... More About Kinetics. 3 references found in Britannica articles. Assorted References. *definition* In dynamics ...
Enzyme Kinetics
Knowledge about the kinetics of an enzyme can reveal useful information about its catalytic mechanism, role in metabolism, ... Enzyme kinetics involves the measurement of the rate at which chemical reactions that are catalyzed by enzymes occur. ... Applications of enzyme kinetics. There are many practical uses of enzyme kinetics. For example, the kinetic constants can help ... www.khanacademy.org/test-prep/mcat/biomolecules/enzyme-kinetics/v/an-introduction-to-enzyme-kinetics ...
Annotated Physics Encyclopædia:
Statistical physics and Kinetics
Electrode kinetics - Wyndham John Albery - Google Books
... describes diffuse double layer diffuse layer distance drop effect electrochemical reaction electrochemistry electrode kinetics ... books.google.comhttps://books.google.com/books/about/Electrode_kinetics.html?id=EY00AAAAMAAJ&utm_source=gb-gplus-shareElectrode ... 0 Reviewshttps://books.google.com/books/about/Electrode_kinetics.html?id=EY00AAAAMAAJ ...
Prostate cancer - PSA and PSA kinetics
PSA kinetics • Change of PSA over time PSA VELOCITY (ng/ml/YEAR) PSA DOUBLING TIME (MONTHS) V1 V2 V3 Vav = (V1+V2+V3)/3 Before ... Prostate cancer - PSA and PSA kinetics * 1. Prostate specific antigen (PSA) Dr Mayank Mohan Agarwal MBBS, MS, MRCS(Ed), DNB, ... 8. Attempts to improve sens-spec of PSA • Age-specific PSA • PSA density • Total • TZ • % free PSA • PSA kinetics • PHI • ...
Microtubule Self-Assembly Kinetics - Durham University
Our current understanding of microtubule assembly kinetics is based on a one-dimensional assembly model, which assumes that ... Biomathematics Seminar: Microtubule Self-Assembly Kinetics. Presented by Davide Odde, University of Minnesota ... we find that the kinetics of microtubule assembly are an order-of-magnitude higher than currently estimated in the literature. ...
chemical kinetics | Definition, Equations, & Facts | Britannica
The principles of chemical kinetics apply to purely physical processes as well as to chemical reactions. ... Chemical kinetics, the branch of physical chemistry that is concerned with understanding how fast or how slow chemical ... Thermodynamics is times arrow, while chemical kinetics is times clock. Chemical kinetics relates to many aspects of cosmology ... Chemical kinetics, the branch of physical chemistry that is concerned with understanding the rates of chemical reactions. It is ...
Thermochemistry and Kinetics | SpringerLink
The kinetics must be known to predict the chemistry quantitatively.. Keywords. Chemical Vapor Deposition Aerosol Particle ... 1980) Thermodynamics and kinetics of chemical vapor deposition of aluminum nitride films. J. Electrochem. Soc., 127, 1532-37. ... Kee, R.J. and Miller, J.A. (1986) A structural approach to the computational modeling of chemical kinetics and transport in ... Nakanishi, N., Mori, S. and Kato, E. (1990) Kinetics of chemical vapor deposition of titanium nitride. J. Electrochem. Soc., ...
Kinetics : Enzyme (7 Variations)
... Trypsin assists in digestion by breaking proteins down into smaller peptides. However, this ... Enzymes, Life Science, Chemistry, Testing / Assessment, NSDL, Kinetics, Chemical Education, Education, Physics ... You just viewed Kinetics : Enzyme (7 Variations). Please take a moment to rate this material. ...
Kinetics - Wikipedia
Kinetics (Ancient Greek: κίνησις, lit. kinesis, movement or to move) may refer to: Kinetics (physics), the study of motion ... the study of the motion of rigid bodies Chemical kinetics, the study of chemical reaction rates Enzyme kinetics, the study of ... now part of the Philips group of companies Kinetics (rapper), rapper and songwriter from New York City Kinetics Internet ... the widely accepted general model of enzyme kinetics Goldbeter-Koshland kinetics, describe a steady-state solution for a 2- ...
Kinetics of a Particle : Force and Acceleration
The basis for kinetics is Newtons second law, which states that when an unbalanced force acts on a particle, the particle will ... The basis for kinetics is Newtons second law, which states that when an unbalanced force acts on a particle, the particle will ... Kinetics of a Particle : Force and Acceleration * 1. Emirate International University Dr. Abduljalil Al-Abidi Dynamics ... Abduljalil Al-Abidi Dynamics Mechatronics Engineering Department PET121 Newton s Second Law of Motion The basis for kinetics ...
Mathematical Models of Blood Coagulation Kinetics | SpringerLink
Kinetics | Definition of Kinetics by Merriam-Webster
Kinetics definition is - a branch of science that deals with the effects of forces upon the motions of material bodies or with ... Comments on kinetics. What made you want to look up kinetics? Please tell us where you read or heard it (including the quote, ... Post the Definition of kinetics to Facebook Share the Definition of kinetics on Twitter ... The first known use of kinetics was circa 1859. See more words from the same year ...
Acetone Removal Kinetics by an Indoor Biofilter
... 1999-01-2069. A biofiltration system was tested to remove low levels of acetone ... Citation: Darlington, A. and Dixon, M., "Acetone Removal Kinetics by an Indoor Biofilter," SAE Technical Paper 1999-01-2069, ... Neither ZERO nor FIRST order kinetics could adequately describe removal. Instead an empirical model that described the natural ...
Gross Chemical Kinetics from Motored Piston Engines
Combustion Kinetics and Emissions | AIChE
Aero Kinetics Launches Online Platform For UAS Position Deposits
Aero Kinetics, the first company to file for FAA Type Certification for multi-rotor unmanned aircraft, has launched ... ABOUT AERO KINETICS: Aero Kinetics is an agile 21st century Aerospace and Defense firm with distinct business units in Unmanned ... Aero Kinetics continues to provide comprehensive UAS solutions. Competitive enterprise lease rates allow Aero Kinetics ... Aero Kinetics has a proven track record of success, spanning more than a decade. We are focused on providing clients with the ...
Corpus Kinetics - PAPER
CORPUS KINETCS This group video exhibition is all about the human bod. Laura Calhoun, Robert OConnor and Bryan Zanisnik have each developed a narrative that expresses various physical functions and meanings. Calhoun, using the body as a place of religious practice, documents a Brazilian ceremony ...
Gas kinetics - Wikipedia
NASA - Microbial Growth Kinetics Under Conditions of Microgravity
Microbial Growth Kinetics Under Conditions of Microgravity (Biokin-4) - 11.22.16. Overview , Description , Applications , ... Microbial Growth Kinetics Under Conditions of Microgravity-4 (Biokin-4) will test the development of biological air filter to ... Microbial Growth Kinetics Under Conditions of Microgravity-4 (Biokin-4) will determine the characteristics of bacterial growth ... Main objective of the presented work is the determination of the influence of the space environment on the growth-kinetics of ...
Kinetics - definition of kinetics by The Free Dictionary
kinetics synonyms, kinetics pronunciation, kinetics translation, English dictionary definition of kinetics. n. 1. See dynamics ... Related to kinetics: Reaction kinetics, Enzyme kinetics, Human kinetics. ki·net·ics. (kə-nĕt′ĭks, kī-). n. (used with a sing. ... Kinetics - definition of kinetics by The Free Dictionary https://www.thefreedictionary.com/kinetics ... kinetics. (kɪˈnɛtɪks; kaɪ-) n (functioning as singular) 1. (General Physics) another name for dynamics2 ...
Nicotine chemistry, metabolism, kinetics and biomarkers. - PubMed - NCBI
Energy Kinetics: A Pioneer in Green Marketing - WSJ
Kinetics leaving Boulder for Longmont
... Share this:. *Click to share on Facebook (Opens in new window) ... Kinetics began as a grass-roots display of creativity in 1980. Later, it picked up a sponsorship from KBCO radio station and, ... the fantastical and wacky Kinetics Sculpture Challenge is planning to make a splash outside Boulder in 2010. ... of Denver put the finishing touches on their craft at Boulder Reservoir during the 2001 KBCO/Budweiser 22nd Annual Kinetics ...
Chemical Kinetics with MATLAB - File Exchange - MATLAB Central
Chemical Kinetics with MATLAB version 1.0.0.0 (187 KB) by Balaji Balaji (view profile). ... This interactive MATLAB document covers concepts relating to chemical kinetics and reaction rates. This module covers concepts ... This interactive MATLAB document covers concepts relating to chemical kinetics and reaction rates. ... Balaji (2020). Chemical Kinetics with MATLAB (https://www.mathworks.com/matlabcentral/fileexchange/63104-chemical-kinetics-with ...
Wiley-VCH - Kinetics of Chemical Reactions
Wiley-VCH, Weinheim Kinetics of Chemical Reactions This textbook presents state-of-the-art of kinetics of chemical reactions as ... Joint Kinetics: A New Strategy in Chemical Kinetics. Decoding the Past. Decoding the Future ... Kinetics of Chemical Reactions. Decoding Complexity. Marin, Guy B. / Yablonsky, Gregory S. / Constales, Denis ... This textbook presents state-of-the-art of kinetics of chemical reactions as an area of challenges and adventures. Concepts are ...
CiteSeerX - Stochastic simulation of chemical kinetics
Researchers are increasingly using this approach to chemical kinetics in the analysis of cellular systems in biology, where the ... After reviewing the supporting theory of stochastic chemical kinetics, I discuss some recent advances in methods for using that ... Abstract Stochastic chemical kinetics describes the time evolution of a wellstirred chemically reacting system in a way that ... species can lead to deviations from the predictions of the deterministic differential equations of classical chemical kinetics ...
Cellular Kinetics of Perivascular MSC Precursors
... William C. W. Chen,1,2 Tea Soon Park,3 Iain R. Murray,4,5 Ludovic Zimmerlin,3 ... In order to further improve MSC-based stem cell therapeutics, it is important to understand the cellular kinetics and ... Through the understanding of their unique cellular kinetics and regenerative potential, we will be able to define the ... and focus on their cellular kinetics: cell adhesion, migration, engraftment, homing, and intercellular cross-talk during tissue ...
EnzymeThermodynamicsHuman KineticsCatalysisStochastic chemical kineticsMechanismsHttpsZero-order kineticsCavendish KineticsMichaelis-MentenChemistryBranchTheoryKineticDynamicsPrinciplesInquiry200022ndCellularStaticsMechanismDelivers2016ApproachCatalyticSingaporeReaction ratesGrowthPlatformsDeterminationSimulationBiologySubsidiaryProstateDescribe
Enzyme15
- In biochemistry , Michaelis-Menten kinetics is one of the best-known models of enzyme kinetics . (wikipedia.org)
- Enzyme kinetics involves the measurement of the rate at which chemical reactions that are catalyzed by enzymes occur. (news-medical.net)
- Knowledge about the kinetics of an enzyme can reveal useful information about its catalytic mechanism, role in metabolism, factors that impact its activity, and mechanisms of inhibition. (news-medical.net)
- This article will cover the basic principles of enzyme kinetics, including the reaction equation, rate of reaction and maximal velocity (V max ) and Michaelis Constant (K m ). (news-medical.net)
- There are many practical uses of enzyme kinetics. (news-medical.net)
- Retrieved on November 15, 2019 from https://www.news-medical.net/life-sciences/Enzyme-Kinetics.aspx. (news-medical.net)
- You just viewed Kinetics : Enzyme (7 Variations) . (merlot.org)
- H. C. Hemker and P. W. Hemker, "General Kinetics of Enzyme Cascades," Proc. (springer.com)
- And look at me, I'm here: I am looking for a shareware/freeware enzyme kinetics program that works in a PC or Win3.1 or Win 95. (bio.net)
- Classical models of enzyme kinetics. (elsevier.com)
- Is the Subject Area "Enzyme kinetics" applicable to this article? (plos.org)
- Practical Enzyme Kinetics provides a practical how-to guide for beginning students, technicians, and non-specialists for evaluating enzyme kinetics using common software packages to perform easy enzymatic analyses. (wiley.com)
- a concise introduction to enzyme kinetics. (wiley.com)
- a valuable companion for everyone seeking a quick overview of the theory of enzyme kinetics. (wiley.com)
- In this review, the enzyme kinetics of CYP inhibitions is described, with the primary focus on the ones proven with clinical relevance, namely the competitive inhibition and mechanism-based inactivation (MBI). (ingentaconnect.com)
Thermodynamics5
- Thermodynamics is time's arrow, while chemical kinetics is time's clock. (britannica.com)
- The database on thermodynamics properties for the chemical species of concern in ceramic synthesis is far better developed than that for the reaction kinetics. (springer.com)
- Are you sure you want to remove Kinetics and thermodynamics in biochemistry from your list? (openlibrary.org)
- The book introduces the reader to the principles of ion-transfer kinetics based on an assumed knowledge of calculus, electrostatics, and thermodynamics. (waterstones.com)
- This subject deals with both chemical thermodynamics and chemical kinetics. (mit.edu)
Human Kinetics16
- Stay on top of the latest news and trends in sport management with updates from Rick Horrow, America's leading expert in sport business, and Human Kinetics, the world's information leader in physical activity. (humankinetics.com)
- Perfect for sports junkies and professionals alike, the iPhone-, iPod Touch-, and iPad-compatible app showcases news analysis from "The Sports Professor," Rick Horrow, along with the latest sport management content from Human Kinetics. (humankinetics.com)
- Human Kinetics publishes books, journals, online courses, video products, and software for fitness enthusiasts and professionals, sport participants and coaches, sport and exercise scientists, physical educators, and many others involved with some area of physical activity. (humankinetics.com)
- Human Kinetics has published with notable associations such as the American College of Sports Medicine (ACSM), the American Football Coaches Association (AFCA), the National Association for Sport and Physical Education (NASPE), Babe Ruth Baseball and Softball, and The Cooper Institute. (humankinetics.com)
- Human Kinetics is the premier information provider in the physical activity field. (humankinetics.com)
- Founded in 1974 by Rainer Martens, a leading sport psychologist and a member of the National Association for Sport and Physical Education Hall of Fame, Human Kinetics has grown from a single release to hundreds of new products each year, including books, videos, software applications, and online education products. (humankinetics.com)
- With over 250 employees globally, including offices in the UK, Canada, and Australia, and a mission to produce innovative resources to help people lead healthier and more active lives, Human Kinetics is truly the worldwide information leader in all areas of physical activity. (humankinetics.com)
- Human Kinetics Student Admissions Human Kinetics is now accepting applications for Fall 2018. (capilanou.ca)
- Explore the human body and its relationship to exercise, sport, and health and leisure activities through the study of Human Kinetics. (capilanou.ca)
- Human Kinetics is the study of human movement from life/physical science, and a social/behavioral science. (capilanou.ca)
- Thus, the Human Kinetics program at Capilano University focuses on the bio-physical and psycho-social dimensions of human movement, exercise, sport, play and the cultural context with which these elements of human behavior have developed and occur. (capilanou.ca)
- Areas of study in the Dept. of Human Kinetics range from cellular analyses neuromuscular function and psycho-social factors influencing human movement, to analyses of social and cultural transformation in the role and function of play, exercise and sport. (capilanou.ca)
- The School of Human Kinetics will admit students to the Human Kinetics Program in the Fall Term only. (capilanou.ca)
- The application deadline is March 15 and the document submission deadline is March 31 (all documents must be submitted to the Human Kinetics Office). (capilanou.ca)
- Capilano University offers a two-year, 60 credit diploma program in Human Kinetics designed for students planning to transfer to the University of British Columbia to complete a Bachelors degree in Human Kinetics. (capilanou.ca)
- Please refer to the Human Kinetics Resources . (capilanou.ca)
Catalysis1
- Covers fundamentals and recent developments in homogeneous catalysis and its modeling from a chemical kinetics perspective. (worldcat.org)
Stochastic chemical kinetics2
- Abstract Stochastic chemical kinetics describes the time evolution of a wellstirred chemically reacting system in a way that takes into account the fact that molecules come in whole numbers and exhibit some degree of randomness in their dynamical behavior. (psu.edu)
- After reviewing the supporting theory of stochastic chemical kinetics, I discuss some recent advances in methods for using that theory to make numerical simulations. (psu.edu)
Mechanisms2
- One reason for the importance of kinetics is that it provides evidence for the mechanisms of chemical processes. (britannica.com)
- Information about reaction mechanisms is also provided by certain nonkinetic studies, but little can be known about a mechanism until its kinetics has been investigated. (britannica.com)
Https2
- Darlington, A. and Dixon, M., "Acetone Removal Kinetics by an Indoor Biofilter," SAE Technical Paper 1999-01-2069, 1999, https://doi.org/10.4271/1999-01-2069 . (sae.org)
- Chemical Kinetics with MATLAB (https://www.mathworks.com/matlabcentral/fileexchange/63104-chemical-kinetics-with-matlab), MATLAB Central File Exchange. (mathworks.com)
Zero-order kinetics1
- I.e it exhibits zero order kinetics? (bio.net)
Cavendish Kinetics2
- Cavendish Kinetics is a fabless semiconductor IP company developing embedded Non-Volatile Memory technology for standard CMOS processes. (xconomy.com)
- Cavendish Kinetics, a fabless semiconductor manufacturer, will use the funds to produce RF Tuning products based on its proprietary NanoMech technology. (xconomy.com)
Michaelis-Menten2
- [1] Biochemical reactions involving a single substrate are often assumed to follow Michaelis-Menten kinetics, without regard to the model's underlying assumptions. (wikipedia.org)
- Finally, the unusual kinetic interactions, which did not follow the Michaelis-Menten (M-M) kinetics, were detected in vitro for the majority of drug-metabolizing CYP members, and manifested for CYP3A4. (ingentaconnect.com)
Chemistry7
- Chemical kinetics , the branch of physical chemistry that is concerned with understanding the rates of chemical reactions . (britannica.com)
- An understanding of the chemistry begins with an examination of the gas composition and equilibrium condensed phases, and continues to the detailed treatment of the gas phase and surface reaction kinetics. (springer.com)
- The kinetics must be known to predict the chemistry quantitatively. (springer.com)
- Topics covered will include, but not limited to, kinetics of pollutant formation, measurements of pollutants, developing new models to predict pollutant chemistry and emissions. (aiche.org)
- Nicotine chemistry, metabolism, kinetics and biomarkers. (nih.gov)
- In chemistry, kinetics refers to the rate and progress of chemical reactions. (wisegeek.com)
- To reduce confusion, in chemistry it is often referred to as chemical or reaction kinetics, to make it clear that chemistry is under discussion. (wisegeek.com)
Branch4
- Kinetics , branch of classical mechanics that concerns the effect of forces and torques on the motion of bodies having mass. (britannica.com)
- In addition, the Kinetics dance school will be expanded to include two locations: the current Ellicott City studio in the Howard County Center for the Arts, and a new Columbia branch at 9200 Old Annapolis Road. (baltimoresun.com)
- Kinetics is a branch of classical mechanics that is focused on the movements of various bodies and the forces that can act on both bodies in motion and bodies at rest. (wisegeek.com)
- Gas kinetics is a science in the branch of fluid dynamics, concerned with the study of motion of gases and its effects on physical systems. (wikipedia.org)
Theory2
- The growth of nanometer sized ZnO particles from solution follows Ostwald ripening kinetics according to the Lifshitz-Slyozov-Wagner (LSW) theory, where the average particle size cubed is equal to the rate constant times time. (foresight.org)
- This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. (waterstones.com)
Kinetic4
- Laboratory measurements of the biologically mediated methylation of mercury (Hg) to the neurotoxin monomethylmercury (MMHg) often exhibit kinetics that are inconsistent with first-order kinetic models. (osti.gov)
- Using time-resolved measurements of filter passing Hg and MMHg during methylation/demethylation assays, a multisite kinetic sorption model, and reanalyses of previous assays, we show in this paper that competing kinetic sorption reactions can lead to time-varying availability and apparent non-first-order kinetics in Hg methylation and MMHg demethylation. (osti.gov)
- The new model employing a multisite kinetic sorption model for Hg and MMHg can describe the range of behaviors for time-resolved methylation/demethylation data reported in the literature including those that exhibit non-first-order kinetics. (osti.gov)
- article{osti_1423042, title = {Kinetics of Methylmercury Production Revisited}, author = {Olsen, Todd A. and Muller, Katherine A. and Painter, Scott L. and Brooks, Scott C.}, abstractNote = {Laboratory measurements of the biologically mediated methylation of mercury (Hg) to the neurotoxin monomethylmercury (MMHg) often exhibit kinetics that are inconsistent with first-order kinetic models. (osti.gov)
Dynamics8
- Authors using the term kinetics apply the nearly synonymous name dynamics ( q.v. ) to the classical mechanics of moving bodies. (britannica.com)
- They include under dynamics both kinetics and kinematics (the description of motion in terms of position, velocity , and acceleration , apart from the influence of forces, torques, and masses). (britannica.com)
- Authors not using the term kinetics divide classical mechanics into kinematics and dynamics, including statics as a special case of dynamics in which the sum of the forces and the sum of the torques are both zero. (britannica.com)
- 2. Emirate International University Dr. Abduljalil Al-Abidi Dynamics Mechatronics Engineering Department PET121 Newton 's Second Law of Motion The basis for kinetics is Newton's second law, which states that when an unbalanced force acts on a particle, the particle will accelerate in the direction of the force with a magnitude that is proportional to the force. (slideshare.net)
- Like dynamics, chemical kinetics has a number of implications for daily life in addition to being involved in abstract theoretical concepts. (wisegeek.com)
- Colloid Formation and Growth: A Chemical Kinetics Approach focuses on the science of colloid dynamics developed from the viewpoint of chemical kinetics. (elsevier.com)
- Houston, P. Chemical Kinetics and Reaction Dynamics . (mit.edu)
- Specifically, this paper reviews the status of multidimensional neutron kinetics modeling which would be used in conjunction with thermal-hydraulic models to do core dynamics calculations, either coupled to a complete NSSS representation or in isolation. (unt.edu)
Principles3
- The principles of chemical kinetics apply to purely physical processes as well as to chemical reactions. (britannica.com)
- Kinetics expands upon these laws, adding some additional principles that help to explain what happens when external forces act on an object. (wisegeek.com)
- The book also supplies sufficient instruction in experimental methodology to allow the reader to study the principles of ion- transfer kinetics experimentally. (waterstones.com)
Inquiry1
- When you click "Send Request", we will send the contact details you supply to Kinetics Noise Control Inc. so they may respond to your inquiry directly. (photonics.com)
20001
- Roger Marran president of Energy Kinetics, and the company's System 2000 boilers, whose first design came from his father, in 1978. (wsj.com)
22nd1
- The Thunder From Down Under team members, Ian Adamson of Boulder, right, and Kirk Roberts of Denver put the finishing touches on their craft at Boulder Reservoir during the 2001 KBCO/Budweiser 22nd Annual Kinetics Sculpture Challenge. (denverpost.com)
Cellular3
- Researchers are increasingly using this approach to chemical kinetics in the analysis of cellular systems in biology, where the small molecular populations of only a few reactant species can lead to deviations from the predictions of the deterministic differential equations of classical chemical kinetics. (psu.edu)
- In order to further improve MSC-based stem cell therapeutics, it is important to understand the cellular kinetics and functional roles of MSCs in the dynamic regenerative processes. (hindawi.com)
- In this review, we will discuss the identification and characterization of perivascular MSC precursors, including pericytes and adventitial cells, and focus on their cellular kinetics: cell adhesion, migration, engraftment, homing, and intercellular cross-talk during tissue repair and regeneration. (hindawi.com)
Statics1
- and the studies of Geometry, Statics, Kinetics , and other kindred subjects, came soon to be considered superfluous, and fell into disrespect and neglect even at our University. (thefreedictionary.com)
Mechanism1
- [2] His work was taken up by German biochemist Leonor Michaelis and Canadian physician Maud Menten , who investigated the kinetics of an enzymatic reaction mechanism, invertase , that catalyzes the hydrolysis of sucrose into glucose and fructose . (wikipedia.org)
Delivers3
- Founded by W. Hulsey Smith in 2003, Aero Kinetics rapidly delivers aerospace and defense technology, services, and solutions to our clients that enable them to maintain technological and operational superiority, by bridging the gap between the conceptual and the tangible. (prweb.com)
- DTCC Investor Kinetics delivers current and historical time series information. (dtcc.com)
- Color Kinetics delivers high-performance professional LED lighting systems in a wide range of types, form factors, and output levels - empowering lighting professionals around the world to achieve their unique visions. (colorkinetics.com)
20161
- 12 January 2016 - US-based investment manager Neuberger Berman has acquired from US-based investment boutique firm Horizon Kinetics , an investment team that manages collateralised index-based options portfolios that seek to capture global volatility premiums, the firm said. (thefreedictionary.com)
Approach1
- Our combinatorial analysis approach involving molecular genetics and kinetics provides a platform for the molecular dissection of the fractal nature of physiological and behavioral phenomena. (nature.com)
Catalytic1
- He is a world recognized expert in the area of chemical kinetics and chemical engineering, in catalytic technology particularly, which is one of main driving forces of sustainable development. (wiley-vch.de)
Singapore1
- ST Kinetics today announced that it signed a collaboration agreement with PBA Group, a leading automation component-product supplier and system integrator, to pursue and undertake new robotics and automation projects in industrial and logistics automation in Singapore and Southeast Asia. (thefreedictionary.com)
Reaction rates2
- This interactive MATLAB document covers concepts relating to chemical kinetics and reaction rates. (mathworks.com)
- Chemical kinetics , also called reaction kinetics , is the study of reaction rates in chemical reactions. (oreilly.com)
Growth7
- Microbial Growth Kinetics Under Conditions of Microgravity-4 (Biokin-4) will test the development of biological air filter to clean-up contaminated air in manned space vehicles. (nasa.gov)
- Microbial Growth Kinetics Under Conditions of Microgravity-4 (Biokin-4) will determine the characteristics of bacterial growth kinetics under microgravity conditions to develop a system for the removal and complete oxidation of gaseous and airborne contaminants originating in confined atmospheres with the use of microorganisms in order to purify and recycle air in manned space aircraft. (nasa.gov)
- Main objective of the presented work is the determination of the influence of the space environment on the growth-kinetics of the biodegradation of the air-contaminant 1,2-dichloroethane by micro-organisms at the degradation of organic volatile contaminants. (nasa.gov)
- In the current presentation results will be shown of base-line data collection to demonstrate the bacterial growth kinetics for the degradation of 1,2-dichloroethane under conditions of gravity (1 g). (nasa.gov)
- In addition, the experimental set-up will be shown for the study of the bacterial growth kinetics for 1,2-dichloroethane that will be performed under microgravity conditions. (nasa.gov)
- In this paper we describe the growth kinetics of ZnO and TiO 2 nanoparticles and show how an understanding of the growth kinetics can be used to synthesize particles with tailored size and morphology. (foresight.org)
- We also show how adsorption of alkanethiols and alkanephosphonic acids influence the growth kinetics. (foresight.org)
Platforms3
- Competitive enterprise lease rates allow Aero Kinetics customers to quickly incorporate unmanned platforms into their business operations without the burden of significant capex costs. (prweb.com)
- Kinetics develops, qualifies, produces and fields systems and components for a wide range of tracked and wheeled armored vehicles as well as for many other stationary and airborne military platforms. (army-technology.com)
- Nevertheless, after five years of intense research in electro-kinetics and other micro-fluidic platforms, a commercially successful device based on advanced micro-fluidic technologies has yet to appear in the market. (thefreedictionary.com)
Determination1
- This is such an exciting development and has given me even more drive and determination to turn Kinetics into a film. (kickstarter.com)
Simulation2
- ARTICLE{Gillespie_stochasticsimulation, author = {Daniel T Gillespie}, title = {Stochastic simulation of chemical kinetics}, journal = {Annu. (psu.edu)
- This is used to guide the students through their use of the simulation to visualize kinetics. (colorado.edu)
Biology1
- Chemical kinetics relates to many aspects of cosmology , geology , biology , engineering , and even psychology and thus has far-reaching implications . (britannica.com)
Subsidiary3
- Southeast Asian sustainable energy provider Sunseap announced last week that it has signed off on a 25-year power purchase agreement (PPA) with ST Kinetics, the land systems and specialty vehicles subsidiary of engineering group, ST Engineering. (pv-tech.org)
- February 23, 2006, LAKE MARY, Fla. Island Air, Hawaii s leading regional airline carrier, has launched a Web check-in solution and self-check-in kiosks from Kinetics, a subsidiary of NCR Corporation ( NYSE: NCR ), designed to provide a quick and convenient travel experience to its passengers. (webwire.com)
- Kinetics, a subsidiary of NCR Corporation ( NYSE: NCR ), is a leading provider of enterprise and self-service technologies to today s travel industry and is the architect of the modern airline self-service era. (webwire.com)
Prostate3
- Objective: To investigate the oncologic outcome and PSA kinetics of localized high-risk prostate cancer (PCa) patients treated with combination strategy of radiation therapy (RT) and maximal androgen blockade (MAB). (urotoday.com)
- Evaluating the influence of prostate-specific antigen kinetics on metastasis in men with PSA recurrence after partial gland therapy. (urotoday.com)
- First off-time treatment prostate-specific antigen kinetics predicts survival in intermittent androgen deprivation for prostate cancer. (urotoday.com)
Describe1
- Neither ZERO nor FIRST order kinetics could adequately describe removal. (sae.org)