The transference of a kidney from one human or animal to another.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The transference of a part of or an entire liver from one human or animal to another.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transference of a pancreas from one human or animal to another.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
A dead body, usually a human body.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The transference of a heart from one human or animal to another.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Pathological processes of the KIDNEY or its component tissues.
Prospective patient listings for appointments or treatments.
The transference of either one or both of the lungs from one human or animal to another.
Transplantation of an individual's own tissue from one site to another site.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Elements of limited time intervals, contributing to particular results or situations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transference of an organ between individuals of the same species or between individuals of different species.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Tissue, organ, or gamete donation intended for a designated recipient.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
The return of a sign, symptom, or disease after a remission.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The period following a surgical operation.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
Excision of kidney.
Cystic mass containing lymph from diseased lymphatic channels or following surgical trauma or other injury.
A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
An institutional policy of granting authority to health personnel to perform procedures on patients or to remove organs from cadavers for transplantation unless an objection is registered by family members or by the patient prior to death. This also includes emergency care of minors without prior parental consent.
Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Tumors or cancers of the KIDNEY.
An insoluble support for an ANTIGEN or ANTIBODIES that is used in AFFINITY CHROMATOGRAPHY to adsorb the homologous antibody or antigen from a mixture. Many different substances are used, among them SEPHAROSE; GLUTARALDEHYDE; copolymers of ANHYDRIDES; polyacrylamides, etc.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Differences in access to or availability of medical facilities and services.
Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Disease having a short and relatively severe course.
Occasions to commemorate an event or occasions designated for a specific purpose.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Transplantation between animals of different species.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Therapy with two or more separate preparations given for a combined effect.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Societal or individual decisions about the equitable distribution of available resources.
Partial or total replacement of the CORNEA from one human or animal to another.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
Kidney disorders with autosomal dominant inheritance and characterized by multiple CYSTS in both KIDNEYS with progressive deterioration of renal function.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Groups of individuals whose putative ancestry is from native continental populations based on similarities in physical appearance.
A country in northern Africa, bordering the Mediterranean Sea, between Egypt, Tunisia, and Algeria, having southern border with Chad, Niger, and Sudan. Its capital is Tripoli.
Testing of immune status in the diagnosis and therapy of cancer, immunoproliferative and immunodeficiency disorders, and autoimmune abnormalities. Changes in immune parameters are of special significance before, during and following organ transplantation. Strategies include measurement of tumor antigen and other markers (often by RADIOIMMUNOASSAY), studies of cellular or humoral immunity in cancer etiology, IMMUNOTHERAPY trials, etc.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
Pathological processes of the LIVER.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Short thick veins which return blood from the kidneys to the vena cava.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Antibodies produced by a single clone of cells.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Payment, or other means of making amends, for a wrong or injury.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.
A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
A condition of an abnormally low level of PHOSPHATES in the blood.
Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Consideration and concern for others, as opposed to self-love or egoism, which can be a motivating influence.
A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.
Antibodies obtained from a single clone of cells grown in mice or rats.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Surgical procedure involving either partial or entire removal of the spleen.
The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
An island in the Greater Antilles in the West Indies, south of Florida. With the adjacent islands it forms the Republic of Cuba. Its capital is Havana. It was discovered by Columbus on his first voyage in 1492 and conquered by Spain in 1511. It has a varied history under Spain, Great Britain, and the United States but has been independent since 1902. The name Cuba is said to be an Indian name of unknown origin but the language that gave the name is extinct, so the etymology is a conjecture. (From Webster's New Geographical Dictionary, 1988, p302 & Room, Brewer's Dictionary of Names, 1992, p132)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Progenitor cells from which all blood cells derive.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Inferior and external epigastric arteries arise from external iliac; superficial from femoral; superior from internal thoracic. They supply the abdominal muscles, diaphragm, iliac region, and groin. The inferior epigastric artery is used in coronary artery bypass grafting and myocardial revascularization.

Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. (1/8017)

BACKGROUND: Although Fas on pancreatic islets promotes autoimmune diabetes in mice, the role of Fas expression on kidney parenchymal cells during autoimmune disease is unknown. METHODS: To determine whether Fas on renal parenchymal cells promotes autoimmune renal destruction, we compared apoptosis and pathology in Fas-intact and Fas-deficient kidneys in an autoimmune milieu. For this purpose, we transplanted single, normal kidneys from MRL-++ (Fas-intact) mice (3 months of age) into age-matched, congenic MRL-Faslpr (Fas-deficient) recipients after removal of nephritic kidneys. These Fas-intact kidneys were compared with Fas-deficient nephritic kidneys. RESULTS: There is a progressive increase of FasL on kidney-infiltrating cells and Fas and FasL on renal parenchymal cells in MRL-++ kidneys during engraftment (0, 2, 4-6, and 8 weeks). By comparison, we detected an increase in FasL in MRL-Faslpr kidneys (3 to 5 months of age), whereas Fas was not detectable. The engagement of T cells bearing FasL with Fas expressing tubular epithelial cells (TECs) induced TEC apoptosis in vitro. However, apoptosis and pathology were similar in kidneys (MRL-++, 8 weeks postengraftment vs. MRL-Faslpr, 5 months) with equivalent amounts of FasL-infiltrating cells or FasL TECs, regardless of Fas on renal parenchymal cells. CONCLUSION: The expression of Fas on renal parenchymal cells does not increase apoptosis or promote renal disease in MRL-++ mice. We speculate that the autoimmune milieu evokes mechanisms that mask, counter, or pre-empt Fas-FasL-initiated apoptosis in MRL kidneys.  (+info)

Sodium reabsorption and distribution of Na+/K+-ATPase during postischemic injury to the renal allograft. (2/8017)

BACKGROUND: A loss of proximal tubule cell polarity is thought to activate tubuloglomerular feedback, thereby contributing to glomerular filtration rate depression in postischemic acute renal failure (ARF). METHODS: We used immunomicroscopy to evaluate the segmental distribution of Na+/K+-ATPase in tubules of recipients of cadaveric renal allografts. Fractional excretion (FE) of sodium and lithium was determined simultaneously. Observations were made on two occasions: one to three hours after graft reperfusion (day 0) and again on post-transplant day 7. An inulin clearance below or above 25 ml/min on day 7 was used to divide subjects into groups with sustained (N = 15) or recovering (N = 16) ARF, respectively. RESULTS: In sustained ARF, the fractional excretion of sodium (FENa) was 40 +/- 6% and 11 +/- 5%, and the fractional excretion of lithium (FELi) was 76 +/- 5% and 70 +/- 2% on days 0 and 7, respectively. Corresponding findings in recovering ARF were 28 +/- 2% and 6 +/- 2% for the FENa and 77 +/- 4% and 55 +/- 3% (P < 0.05 vs. sustained) for FELi. Na+/K+-ATPase distribution in both groups was mainly basolateral in distal straight and convoluted tubule segments and collecting ducts. However, Na+/K+-ATPase was poorly retained in the basolateral membrane of proximal convoluted and straight tubule segments in sustained and recovering ARF on both days 0 and 7. CONCLUSIONS: We conclude that loss of proximal tubule cell polarity for Na+/K+-ATPase distribution is associated with enhanced delivery of filtered Na+ to the macula densa for seven days after allograft reperfusion. Whether an ensuing activation of tubuloglomerular feedback is an important cause of glomerular filtration rate depression in this form of ARF remains to be determined.  (+info)

Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients. (3/8017)

BACKGROUND: Hyperhomocysteinemia is an established, independent risk factor for vascular disease morbidity and mortality. The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T has been shown to result in increased total homocysteine concentrations on the basis of low folate levels caused by a decreased enzyme activity. The effect of this polymorphism on total homocysteine and folate plasma levels in renal transplant patients is unknown. METHODS: We screened 636 kidney graft recipients for the presence of the MTHFR C677T gene polymorphism. The major determinants of total homocysteine and folate plasma concentrations of 63 patients, who were identified to be homozygous for this gene polymorphism compared with heterozygotes (N = 63), and patients with wild-type alleles (N = 63), who were matched for sex, age, glomerular filtration rate (GFR), and body mass index, were identified by analysis of covariance. The variables included sex, age, GFR, body mass index, time since transplantation, folate and vitamin B12 levels, the use of azathioprine, and the MTHFR genotype. To investigate the impact of the kidney donor MTHFR genotype on total homocysteine and folate plasma concentrations, a similar model was applied in 111 kidney graft recipients with stable graft function, in whom the kidney donor C677T MTHFR gene polymorphism was determined. RESULTS: The allele frequency of the C677T polymorphism in the MTHFR gene was 0.313 in the whole study population [wild-type (CC), 301; heterozygous (CT), 272; and homozygous mutant (TT), 63 patients, respectively] and showed no difference in the patient subgroups with various renal diseases. The MTHFR C677T gene polymorphism significantly influenced total homocysteine and folate plasma concentrations in renal transplant recipients (P = 0.0009 and P = 0.0002, respectively). Furthermore, a significant influence of the GFR (P = 0.0001), folate levels (P = 0.0001), age (P = 0.0001), body mass index (P = 0.0001), gender (P = 0.0005), and vitamin B12 levels (P = 0.004) on total homocysteine concentrations was observed. The donor MTHFR gene polymorphism had no influence on total homocysteine and folate levels. Geometric mean total homocysteine levels in patients homozygous for the mutant MTHFR allele were 18.6 micromol/liter compared with 14.6 micromol/liter and 14.9 micromol/liter in patients heterozygous for the MTHFR gene polymorphism and those with wild-type alleles (P < 0.05 for TT vs. CT and CC). Geometric mean folate levels were lower in CT and TT patients (11.2 and 10.2 nmol/liter) compared with CC patients (13.6 nmol/liter, P < 0.05 vs. CT and TT). CONCLUSIONS: This study demonstrates that homozygosity for the C677T polymorphism in the MTHFR gene significantly increases total homocysteine concentrations and lowers folate levels in kidney graft recipients, even in patients with excellent renal function (GFR more than median). These findings have important implications for risk evaluation and vitamin intervention therapy in these patients who carry an increased risk for the development of cardiovascular disease.  (+info)

Flow-mediated vasodilation and distensibility of the brachial artery in renal allograft recipients. (4/8017)

BACKGROUND: Alterations of large artery function and structure are frequently observed in renal allograft recipients. However, endothelial function has not yet been assessed in this population. METHODS: Flow-mediated vasodilation is a useful index of endothelial function. We measured the diameter and distensibility of the brachial artery at rest using high-resolution ultrasound and Doppler frequency analysis of vessel wall movements in the M mode. Thereafter, changes in brachial artery diameter were measured during reactive hyperemia (after 4 min of forearm occlusion) in 16 cyclosporine-treated renal allograft recipients and 16 normal controls of similar age and sex ratio. Nitroglycerin-mediated vasodilation was measured to assess endothelium-independent vasodilation. Brachial artery blood pressure was measured using an automatic sphygmomanometer, and brachial artery flow was estimated using pulsed Doppler. RESULTS: Distensibility was reduced in renal allograft recipients (5.31 +/- 0. 74 vs. 9.10 +/- 0.94 x 10-3/kPa, P = 0.003, mean +/- sem), while the brachial artery diameter at rest was higher (4.13 +/- 0.14 vs. 3.25 +/- 0.14 mm, P < 0.001). Flow-mediated vasodilation was significantly reduced in renal allograft recipients (0.13 +/- 0.08 vs. 0.60 +/- 0.08 mm or 3 +/- 2 vs. 19 +/- 3%, both P < 0.001). However, nitroglycerin-mediated vasodilation was similar in renal allograft recipients and controls (0.76 +/- 0.10 vs. 0.77 +/- 0.09 mm, NS, or 19 +/- 3 vs. 22 +/- 2%, NS). There were no significant differences in brachial artery flow at rest and during reactive hyperemia between both groups. The impairments of flow-mediated vasodilation and distensibility in renal allograft recipients remained significant after correction for serum cholesterol, creatinine, parathyroid hormone concentrations, end-diastolic diameter, as well as blood pressure levels, and were also present in eight renal allograft recipients not treated with cyclosporine. Flow-mediated vasodilation was not related to distensibility in either group. CONCLUSIONS: The results show impaired endothelial function and reduced brachial artery distensibility in renal allograft recipients. The impairments of flow-mediated vasodilation and distensibility are not attributable to a diminished brachial artery vasodilator capacity, because endothelium-independent vasodilation was preserved in renal allograft recipients.  (+info)

A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (5/8017)

BACKGROUND: Between September 20, 1995 and September 20, 1997, 208 adult patients undergoing renal transplantation were randomized to receive tacrolimus/prednisone (n=106) or tacrolimus/prednisone/mycophenolate mofetil (n=102), with the goal of reducing the incidence of rejection. METHODS: The mean recipient age was 50.7+/-13.7 years. Sixty-three (30.3%) patients were 60 years of age or older at the time of transplantation. The mean donor age was 34.5+/-21.7 years. The mean cold ischemia time was 30.5+/-9.2 hr. The mean follow-up is 15+/-7 months. RESULTS: The overall 1-year actuarial patient survival was 94%; the overall 1-year actuarial graft survival was 87%. When the patient and graft survival data were stratified to recipients under the age of 60 who did not have delayed graft function, the overall 1-year actuarial patient survival was 97%, and the corresponding 1-year actuarial graft survival was 93%. There were no differences between the two groups. The overall incidence of rejection was 36%; in the double-therapy group, it was 44%, whereas in the triple therapy group, it was 27% (P=0.014). The mean serum creatinine was 1.6+/-0.8 mg/dl. A total of 36% of the successfully transplanted patients were taken off prednisone; 32% of the patients were taken off antihypertensive medications. The incidence of delayed graft function was 21%, the incidence of cytomegalovirus was 12.5%, and the initial and final incidences of posttransplant insulin-dependent diabetes mellitus were 7.0% and 2.9%; again, there was no difference between the two groups. CONCLUSIONS: This trial suggests that the combination of tacrolimus, steroids, and mycophenolate mofetil is associated with excellent patient and graft survival and a lower incidence of rejection than the combination of tacrolimus and steroids.  (+info)

The spouse as a kidney donor: ethically sound? (6/8017)

A shortage of cadaver donor organs requires transplant units to examine all possible alternatives. Transplantation from living donors accounts for only approximately 10% of kidney transplants in the UK. Recent studies have shown that the results of kidney transplantation between spouses are at least as good as those of well-matched cadaver organs, but very few transplants of this type have been performed in this country so far. As part of the assessment process, the proposed donor and recipient are required to provide written statements about the issues. We reproduce here the personal statements made by one of our patients and his wife: we believe that the statements support our contention that spousal transplantation is ethically justifiable and should be more widely available. We report our early experience in Bristol with seven kidney transplants from spousal donors and we encourage other renal units in this country and elsewhere to consider this method of improving the prospects of kidney transplantation for their patients.  (+info)

Incidence of analgesic nephropathy in Berlin since 1983. (7/8017)

BACKGROUND: Phenacetin was removed from the German market in 1986 and was replaced mainly in analgesic compounds by acetaminophen. Our objective was to examine the effect of this measure on the incidence of analgesic nephropathy in light of the changes in other end-stage renal diseases. METHODS: We therefore compared the proportion of renal diseases in all patients starting dialysis treatment during three 18-month periods: 4/1982-9/1983 (n=57); 1/1991-6/1992 (n=81); and 10/1995-3/1997 (n=76). RESULTS: On the one hand, the proportion of end-stage analgesic nephropathy decreased significantly from 30% in 1981-1982 to 21% in 1991-1992 and 12% in 1995-1997 (P=0.01). On the other hand, type II diabetes increased significantly from 7% to 22% (P=0.01) and 29%, (P=0.001). Using the chi2 distribution test to analyze the frequencies of seven diseases at three different time intervals, however, showed that the changes in renal-disease proportions between 1982-1983, 1991-1992 and 1995-1997 were not significantly independent. There was a significant median age increase from 52 years (CI0.95 44-58) in 1982-1983 to 63 (CI0.95 55-67) in 1991-1992 and 63 (CI0.95 60-66) in 1995-1997 (P=0.003) for all patients starting dialysis but not for those with analgesic nephropathy [59 (55-71) vs 64 (53-67) and 61 (50-72); n.s.]. CONCLUSION: The decrease of end-stage analgesic nephropathy since 1983 may be partially due to the removal of phenacetin from the German market in 1986. However, considering the general increase in numbers of dialysis patients, their higher age and the increased incidence of type II diabetes, the decrease in analgesic nephropathy is not a statistically significant independent variable. Altered admittance policies for dialysis treatment have yielded a new pattern of renal-disease proportion which interferes with changes in the incidence of analgesic nephropathy.  (+info)

Studies on structural changes of the carotid arteries and the heart in asymptomatic renal transplant recipients. (8/8017)

BACKGROUND: The present study was designed to characterize early structural changes of large arteries in renal transplant recipients with no clinical evidence of cardiovascular disease and normal blood pressure values, and to analyse the relationship between arterial alterations and those of the heart. METHODS: Intima media thickness and atherosclerotic plaques of the carotid arteries as well as left ventricular geometry and function were examined in 35 asymtomatic renal transplant recipients and 29 age- and sex-matched healthy controls by high resolution B-mode ultrasound and by echocardiography. RESULTS: Intima-media thickness of the carotid arteries was significantly higher in renal transplant recipients (1.21+/-0.08 mm) than in healthy controls (0.74+/-0.04 mm) (P<0.001). Atherosclerotic plaques were found in the majority of renal transplant recipients (71% vs 14% in healthy controls, P<0.001). Left ventricular mass index was significantly increased in the group of renal transplant recipients (264+/-13 g, 146+/-7 g/m2) when compared with healthy controls (155+/-8 g, 83+/-4 g/m2) (P<0.001). Multiple regression analysis in renal transplant recipients showed that intima media thickness of the carotid arteries was significantly related to left ventricular mass index (P<0.02), but not to age, blood pressure, body mass index, serum creatinine, cholesterol and lipoprotein (a) levels. In the group of healthy controls, intima-media thickness of the carotid artery was related to age (P<0.002), but not to left ventricular mass index or the other independent variables. CONCLUSIONS: The present study documents pronounced intima-media thickening in asymptomatic renal transplant recipients. Atherosclerotic lesions are present in most renal transplant recipients with no clinical evidence of cardiovascular disease. We observed a parallelism between arterial wall thickening and left ventricular hypertrophy, although blood pressure levels were normal during haemodialysis therapy and after renal transplantation.  (+info)

TY - JOUR. T1 - Unusual presentations of BK virus infections in pediatric renal transplant recipients. AU - Drake, Keri A.. AU - Najera, Lydia. AU - Reed, Robyn C.. AU - Verghese, Priya S.. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2013/2. Y1 - 2013/2. N2 - BKV has emerged as a significant pathogen in the field of transplantation, predominantly causing BKV nephropathy in renal transplant recipients and hemorrhagic cystitis in HSCT recipients. However, case reports describe more diverse complications, and we too present three unusual cases of BKV infections in pediatric renal transplant recipients. First, we describe a case of biopsy-proven renal damage secondary to BKV prior to the onset of viremia, demonstrating that BKV nephropathy can occur without preceding viremia. We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. Therefore, we conclude that BKV ...
TY - JOUR. T1 - Posttransplant diabetes mellitus in pediatric renal transplant recipients. T2 - A report of The North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). AU - Al-Uzri, Amira. AU - Stablein, Donald M.. AU - Cohn, Richard A.. PY - 2001/9/27. Y1 - 2001/9/27. N2 - Background. The incidence of renal post transplant diabetes mellitus (PTDM) in adults varies from 3-46%. Methods. We did a retrospective analysis of 1365 children in The North American Pediatric Renal Transplant Cooperative Study with renal transplant (Tx) reported between January 92 and July 1997. PTDM, defined as ,2 weeks of insulin therapy after Tx, developed in 36 patients. A control group of 153/1329 non-PTDM patients was selected and matched for age at Tx and primary diagnosis. Results. African-Americans were overrepresented (36.1 vs. 17.6%, P=0.017) and Hispanics were underrepresented (5.6 vs. 26.1%, P=0.019) among cases. Although prednisone dose 30 days post-Tx was higher among cases (0.89 mg/kg/day) ...
Purpose To determine the impact of transplant nephrectomy on morbidity and mortality and HLA immunization. Methods All patients who underwent transplant nephrectomy in our centre between 2000 and 2016 were included in this study. A total of 2822 renal transplantations and 180 transplant nephrectomies were performed during this period. Results The indications for transplant nephrectomy were graft intolerance syndrome: 47.2%, sepsis: 22.2%, vascular thrombosis: 15.5%, tumour: 8.3% and other 6.8%. Transplant nephrectomies were performed via an intracapsular approach in 61.7% of cases. The blood transfusion rate was 50%, the morbidity rate was 38% and the mortality rate was 3%. Transplant nephrectomies more than 12 months after renal transplant failure were associated with more complications (p = 0.006). Transfusions in the context of transplant nephrectomy had no significant impact on alloimmunization. Conclusion The risk of bleeding, and therefore of transfusion, constitutes the major challenge of this
kidney information, kidney education, kidney transplant information, Kidney Transplantation, Pre kidney transplant information, Paired kidney donation, Pre-emptive kidney transplant, post kidney Transplantation care, post kidney Transplantation drugs, post kidney Transplantation medications, post kidney Transplantation precautions, Precautions after Kidney Transplant, Deceased kidney transplantation, Cadaveric kidney transplantation, Brain death, what is brain death, diagnosis of brain death, information after kidney transplant, kidney transplant procedure, kidney transplant rejection, kidney transplant surgery, renal transplantation, kidney donation, kidney removal, organ donation, kidney transplantation indications, kidney transplantation advantages, kidney transplantation disadvantages, donor selection for kidney transplantation, who can donate kidney, post kidney transplantation complications, guidelines for transplanted kidney
Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P lt 0.001), but more HDL 3a (P lt 0.01) and 3b (P lt 0.001) subclasses. They also had increased sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05) levels. The proportion ...of the HDL 3b ...
Advanced chronic kidney disease often results in adverse cardiovascular outcomes and is the leading cause of mortality in patients with end stage renal diseases (ESRD). There is much information about the effect of chronic kidney diseases (CKD) on the left ventricle (LV) chamber, but the right ventricle (RV) as a neglected chamber had not been evaluated precisely, in spite of its importance. The aim of this study was to evaluate the impact of successful kidney transplants on the RV systolic and diastolic function using the advanced method of 2D speckle tracking echocardiography and comparison with the conventional methods. The study included 48 patients with CKD who were eligible for kidney transplantation and underwent successful kidney transplantations. Right ventricular indices were evaluated, while RV function was focused by conventional methods and 2D speckle tracking echocardiography before the successful kidney transplant and 1 week, 1 month, and 3 months after the successful kidney transplant.
Introduction: The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. However, the clinical significance of dnDSA in patients with a stable creatinine remains unclear. Methods: We performed a retrospective cohort study of 103 patients receiving a first, kidney alone transplant between 12/1/2007 and 12/31/2013. Inclusion criteria were age ,18 years old at the time of transplant and at least two years of DSA monitoring. All patients underwent DSA screening every 3 months post-transplant with additional testing as clinically indicated. No treatment was given for DSAs in the absence of biopsy-proven rejection. Results: 20 patients (19%) developed dnDSA in the setting of a stable creatinine and 13 patients (13%) developed dnDSA in the setting of an elevated creatinine. Median follow-up time post-transplant was 4.1 (IQR 2.9-5.7) years. In a Cox ...
By B.DULGUUN. The first kidney transplant procedure in 1996 by Mongolian doctors was unsuccessful. After ten years, State Honored Doctor L.Jambaljav and his colleagues from the Mongolian National Central Hospital No.1 successfully conducted a kidney transplant procedure. Currently, State Honored Doctor and Professor of Chronic Kidney Disease Clinic D.Nyamsuren is working as the head of the Kidney Transplant Center team at the National Central Hospital. He has been working with the team since the introduction of kidney transplantation in Mongolia and saved 79 lives. Below is an interview with D.Nyamsuren about kidney transplantation in Mongolia.. -Whats the current actual cost of kidney transplantation?. -The National Central Hospital No.1 conducts kidney transplantation for 12 million MNT. Eight million is paid by the Ministry of Health package and the rest by the patient. At our current price, this budget is not sufficient. The National Central Hospital No.1 is able to transplant kidneys for ...
A three sequence, open-label, multi-center, prospective, study in stable kidney transplant patients to assess and compare the pharmacokinetics (Cmax, C24, and AUC), and safety of LCP-Tacro (tacrolimus) tablets versus Prograf (tacrolimus) capsules.. Stable kidney transplant patients who fulfill all I/E criteria will be enrolled and kept on Prograf for 7 days. Following a 24-hour PK study on Day 7 to determine pharmacokinetics for Prograf, all patients will be converted to once daily LCP-Tacro for 7 days with no dose changes allowed. On Day 14 and Day 21 a 24-hour LCP-Tacro PK study will be performed. On Day 22 patients will be converted back to their original twice daily dose of Prograf for a safety follow-up period of 30 days ending with a safety assessment on day 53. ...
Partial table of contents: A Short History of Renal Transplantation (R. Calne). Considerations in Organ Transplantation (R. Kerman). Pretransplantation and Posttransplantation Psychosocial Evaluation. (G. Wolff). Impact of Recipient Age on Renal Allograft Outcome (G. Arbus & D. Hebert). Steroid Withdrawal After Renal Transplantation (E. Ingulli & A. Tejani). Treatment of Acute Rejection (G. Offner). Urologic Complications in Renal Transplantation (O. Salvatierra). Noncompliance to Medical Regimens (B. Cole). Malignancy in Children (I. Penn). Long-Term Outcome of Kidney Transplantation in Children (D. Potter). Index.Pediatric Renal Transplantation, 1 was published 1994 under ISBN 9780471591207 and ISBN 0471591203. [read more] ...
PRIMARY OBJECTIVES:. I. To assess human papillomavirus (HPV) vaccine-type-specific seroconversion rates at 12-months post-transplantation among kidney transplant recipients who receive ,= 1 doses of the recombinant human papillomavirus nonavalent vaccine (Gardasil 9 HPV vaccine) ,= 30 days prior to transplantation.. SECONDARY OBJECTIVES:. I. To evaluate the following in adult kidney transplant recipients who receive ,= 1 doses of the Gardasil 9 HPV vaccine prior to transplantation:. Ia. HPV vaccine-type-specific seroconversion rates at 12-months post-transplantation.. Ib. Persistence and stability of HPV vaccine-type-specific geometric mean titers (GMT) at 6 and 12-months post-transplantation, and rise in HPV vaccine-type-specific GMT at the 13 month post-transplant visit.. Ic. Vaccine safety profile and allograft rejection/opportunistic infections stratified by number of vaccine doses and time between the last vaccine dose and the transplant procedure.. Id. HPV detection in self-collected ...
BACKGROUND: C-reactive protein (CRP) is a predictor of coronary heart disease, total mortality and chronic allograft nephropathy in renal transplant recipients. The determinants of CRP have been investigated in the general population, but not in renal transplant recipients. CRP might reflect metabolic aberrations in association with central obesity and systemic atherosclerosis. However, it may also reflect a low-grade immune-mediated response to the graft. In this study we investigated the factors associated with CRP in a renal transplant population. METHODS: Between August 2001 and July 2003, renal transplant recipients with a functioning graft for more than 1 year (n = 847) were eligible for investigation at their next visit to the outpatient clinic. A total of 606 patients (55% male, aged 51+/-12 years) participated at a median (interquartile range) time of 6.0 (2.6-11.4) years post-transplant. RESULTS: Median CRP concentration was 2.0 (0.80-4.8) mg/l and mean 24 h creatinine clearance was 62+/-22 ml
The ultimate goal of clinical transplantation is for the recipients to achieve long-term survival, with continuing graft function, that is equivalent to that of the age-matched general population. We studied subsequent outcome in kidney transplant recipients with 10 years of graft function. In all, 2202 kidney transplant recipients survived with graft function ,10 years. For 10-year survivors, the actuarial 25-year patient survival rate for primary transplant living donor (LD) recipients was 57%; graft survival, 43%. For primary transplant deceased donor (DD) recipients, the actuarial 25-year patient survival rate was 39%; graft survival, 27%. The two major causes of late graft loss were death (with graft function) and chronic allograft nephropathy (tubular atrophy and interstitial fibrosis). The two major causes of death with function were cardiovascular disease (CVD) and malignancy. For nondiabetic recipients, the mean age at death with function from CVD was 54 ± 13 years; for diabetic ...
PubMed journal article: Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. Download Prime PubMed App to iPhone, iPad, or Android
Uremia has long been recognized to disrupt the normal physiology of numerous organs, including the heart (2,3). Over the last 30 years, echocardiography studies have found adverse changes in cardiac structure and function associated with end-stage renal disease (ESRD), which is collectively termed uremic cardiomyopathy. These cardiac abnormalities, including left ventricular hypertrophy and systolic dysfunction, are common in hemodialysis and are associated with an increased risk of adverse clinical outcomes (4). However, the precise nature of the uremic mediators of cardiac dysfunction remain elusive. Kidney transplantation is the treatment of choice for selected patients with ESRD. A successful kidney transplantation improves the quality of life and reduces the mortality risk for most patients compared with maintenance dialysis (5). However, 50% to 60% of deaths among kidney transplantation recipients are directly attributable to cardiovascular disease. In addition, death from cardiovascular ...
TY - JOUR. T1 - Early renal function recovery and long-term graft survival in kidney transplantation. AU - Wan, Susan S.. AU - Cantarovich, Marcelo. AU - Mucsi, I.. AU - Baran, Dana. AU - Paraskevas, Steven. AU - Tchervenkov, Jean. PY - 2016/5/1. Y1 - 2016/5/1. N2 - Following kidney transplantation (KTx), renal function improves gradually until a baseline eGFR is achieved. Whether or not a recipient achieves the best-predicted eGFR after KTx may have important implications for immediate patient management, as well as for long-term graft survival. The aim of this cohort study was to calculate the renal function recovery (RFR) based on recipient and donor eGFR and to evaluate the association between RFR and long-term death-censored graft failure (DCGF). We studied 790 KTx recipients between January 1990 and August 2014. The last donor SCr prior to organ procurement was used to estimate donor GFR. Recipient eGFR was calculated using the average of the best three SCr values observed during the first ...
The Banff Classification is a schema for nomenclature and classification of renal allograft pathology, established in 1991 by Kim Solez and Lorraine C. Racusen in Banff, Canada. The initiative was inspired by the then recent development of a consensus grading system for diagnosis of rejection in cardiac allografts led by Dr Margaret Billingham, a key participant at the first Banff meeting. Prior the Banff Classification there was no standardized, international classification for renal allograft biopsies, which resulted in considerable heterogeneity among pathologists in characterization of renal allograft biopsies. The first Banff schema was published in 1993, and has since undergone updates at regular intervals. The classification is expanded and updated every two years in meetings organized by the Banff Foundation for Allograft Pathology. An evaluation of the Banff Classification in March 2000 confirmed significant association between the revised Banff 97 classification and graft outcome. ...
Background: Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients. Methods: During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction [Med Arch 2017; 71(6.000): 408-411]. Keywords: End-stage renal disease, Echocardiography, Kidney transplantation, Cardiovascular disease. >>Full text PDF >>Abstract >>(10.5455/medarh.2017.71.408-411). ...
Requiring a formal patient education class may help reduce disparities in kidney failure patients access to kidney transplantation.. Being educated about your health and your treatment options is a good thing. According to a new study, kidney failure patients who take part in an education program are more likely to get evaluated for a kidney transplant. The study appears in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that requiring a formal patient education class may help reduce inequities in kidney failure patients access to kidney transplantation.. Kidney transplantation is the preferred treatment for kidney failure. Among kidney failure patients, blacks are less likely to receive kidney transplants than whites for reasons that are unclear. Unfortunately, few published studies have looked at interventions that might reduce such racial disparities in access to kidney transplantation.. In an attempt to educate patients about the ...
OBJECTIVE Renal transplantation with a well-functioning graft leads to a rapid restoration of endocrine and sexual functions. The aim of this study was to examine our experience with pregnancies among renal transplant patients, particularly with regard to their impact on graft function. PATIENTS AND METHODS We analyzed 10 pregnancies in 7 renal transplant recipients for long-term graft outcomes in terms of clinical and biological data. RESULTS The mean patient age was 28.5 +/- 4 years. They all received a living donor kidney. The time between transplantation and the onset of pregnancy was 33.4 +/- 23.2 months. Regarding the immunosuppressive therapy, all patients received steroids and cyclosporine; 4 patients received in addition azathioprine and 2 received mycophenolate mofetil that was changed at 1 month before conception to azathioprine. There was no significant difference between the serum creatinine before and during pregnancy. We did not observe any acute rejection episode. Pregnancy
Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals.. Although avoiding HLA [human leukocyte antigen; cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term graft survival, it has raised concerns about disadvantaging minority groups, particularly black patients, and pediatric patients, who have severe growth retardation and other problems when dialysis is prolonged before transplantation, the authors write as background information in the article. Currently, only HLA-DR matching is considered in the United Network for Organ Sharing (UNOS) organ allocation system.. To examine the relationship between HLA-DR mismatching and rejection, graft survival and ...
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A kidney transplant is a life-changing and life-saving procedure. Yet, a new study conducted by Mayo Clinic and the University of Michigan shows that only one-third of patients who ultimately receive a living donor kidney transplant receive it pre-emptively (i.e., before starting dialysis). Less than two-thirds receive a transplant either pre-emptively or within a year of starting dialysis.. Existing research suggests that less time spent on dialysis before transplant can improve patient outcomes and survival after transplant. However, this new research shows there has been no increase in the utilization of what is known as timely living donor kidney transplants, which includes pre-emptive and early transplants, since 2006. The study Under-utilization of timely kidney transplants in those with living donors, was published recently in the American Journal of Transplantation.. Read more. ...
TY - JOUR. T1 - Cancer and mTOR inhibitors in kidney transplantation recipients. AU - Kao, Chih Chin. AU - Liu, Jia Sin. AU - Chang, Yu Kang. AU - Lin, Ming Huang. AU - Lin, Yen Chung. AU - Chen, Hsi Hsien. AU - Chang, Wei Chiao. AU - Hsu, Chih Cheng. AU - Wu, Mai Szu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background: Previous studies show that mTOR inhibitors decrease the risk of cancer development after kidney transplantation. However, the effect of cumulative doses of mTOR inhibitors on cancer after kidney transplantation is not well known. Methods: In the current study, patients were registered into a national database in Taiwan. Between year 2000 and 2013, 4,563 patients received kidney transplantation. They were divided into two groups, according to mTOR inhibitors usage. The cumulative dose of mTOR inhibitors was recorded. Patients were followed-up until de novo cancer development, death, or the end of 2014. Results: Patients were divided into two groups: mTOR inhibitors users (study group, ...
TY - JOUR. T1 - Severe neurologic toxicity induced by cyclosporine A in three renal transplant patients. AU - Palmer, B. F.. AU - Toto, R. D.. PY - 1991. Y1 - 1991. N2 - Cyclosporine A (CyA) is a potent immunosuppressive agent that is used in organ transplantation and in a variety of immunological diseases. It has a variety of adverse side effects, some of which can be serious and even life-threatening. CyA-associated neurotoxicity is generally mild, consisting of fine tremor. However, more complex neurologic abnormalities, including motor spinal cord and cerebellar syndromes, have rarely been described in bone marrow and liver transplant patients. Renal transplant patients have been spared from such CyA-induced toxicity. In this report, three renal transplant patients are described who developed complex and severe neurologic toxicity in the setting of therapeutic blood levels of CyA, which was completely reversible on discontinuation of the drug. No patient had a prior history of neurological ...
TY - JOUR. T1 - Glomerular filtration rate in children following renal transplantation. AU - Seikaly, Mouin G.. AU - Browne, Richard. AU - Simonds, Nancy. AU - Atkins, Carolyn. AU - Alexander, Steven R.. PY - 1998/8/1. Y1 - 1998/8/1. N2 - Most studies evaluating renal function post-renal transplantation in children have used serum creatinine (SCr) or estimates of its clearance (CSCH). When renal function is impaired both SCr and the CSCH overestimate glomerular filtration rate (GFR), especially during cyclosporine therapy. This study measured GFR in 64 children (age range: 4-19 years) with stable renal function who received renal allografts at the Childrens Medical Center of Dallas, 31 from live related donors (LRD) and 33 from cadaveric donors (CAD). 125I- iothalamate clearance (CIO) was used as the reference standard for measuring GFR. Data from 100 CIO studies, were analyzed and results reported as mean ± S.E.M. CIO performed during the first year after renal transplantation in 23 children ...
TY - JOUR. T1 - Kidney allograft survival outcomes in combined intestinal-kidney transplant. T2 - An analysis of the UNOS/OPTN database 2000-2014. AU - Moinuddin, Irfan. AU - Yaqub, Muhammad Sohail. AU - Taber, Tim. AU - Mujtaba, Muhammad. AU - Sharfuddin, Asif. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background and objectives: Intestinal transplants carry a high morbidity/mortality. Kidney allograft outcomes after combined intestinal (IT) with kidney transplant (CIKT) remain largely uninvestigated. Materials and methods: The UNOS STAR database was queried to identify all such combined organ transplants from 2000 to 2015. Results: Out of a total 2215 (51.4% peds vs 48.6% adults) intestinal transplants, 111 (5.0%) CIKT were identified (32.4% peds vs 67.6% adults). Over the study period of CIKT, a total of 45.9% of these cases died with a functioning kidney graft. DGF rate was 9.0%. The 1-year reported kidney acute rejection rate was 6.3%. For the entire CIKT population over the entire study era, the ...
EBV viremia occurs frequently after transplantation and can be related to post-transplant lymphoproliferative disorders (PTLD). However, the consequences of the majority of viremia are unclear. Barnoulid et al. followed EBV viral loads in 383 kidney transplant patients during the first year post-transplant. 40% of patients had at least one detected viremia; viremia was more common in EBV mismatched patients and those that received ATG. While these risk factors for EBV are well known, the authors also found that EBV infection was associated with opportunistic infection and graft loss. This study adds to our knowledge on EBV although further work is necessary to determine what to do with patients who had chronic low level viremia.. ...
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Definition of kidney transplantation in the dictionary. Meaning of kidney transplantation. What does kidney transplantation mean? Information and translations of kidney transplantation in the most comprehensive dictionary definitions resource on the web.
UAB has become a national leader in kidney transplantation since performing our programs first kidney transplant in 1968. Currently, the UAB Kidney Transplant Program is one of the largest kidney transplant centers in the nation, performing almost 300 transplants each year. Our reputation for excellence is based on our highly skilled transplant doctors, multidisciplinary team of specialists, dedication to patient care and education, and exceptionally high patient survival rates. Moreover, our patients benefit from our long history of experience and achievement in kidney transplantation. Since 1987, UAB has performed more living donor kidney transplants than any other kidney program in the United States, according to the United Network for Organ Sharing.. In 2006, UAB became the first transplant center in the Southeast to pursue paired-kidney exchange, a special type of living-donor arrangement. Blood-type and tissue incompatibility can be barriers to a successful donor-recipient match. However, ...
Introduction: Direct-acting antivirals (DAAs) are widely used in the treatment of hepatitis C virus (HCV) infection in renal transplant recipients. Aim: The aim was to study the efficacy and safety of these drugs in our renal transplant recipients. Study Design, Subjects, and Methods: A retrospective observational study was performed among the renal transplant recipients , 18 years of age who were treated with DAA for HCV infection. The viral genotype, DAA regimen, the viral load at various time intervals, FibroScan score at the start and at the end of therapy, the changes in graft function (estimated glomerular filtration rate) and in the dosage of calcineurin inhibitors during therapy, and side effects if any during therapy were documented from history and transplant records. The viral remission rates and the safety of DAA were analyzed. Statistical analysis was done with Medcalc statistical software version Results: Thirty-three recipients were included in the study. The DAA ...
As Dr. Cooper took on this new role, the Division also hired two new physicians so that we can offer patients a full team of experts and comprehensive care.. Dr. Charles Strom is a transplant surgeon specializing in kidney transplants. After earning his medical degree from the University of Massachusetts Medical School, he completed his general surgery residency at St. Elizabeths Medical Center in Boston and his fellowship in abdominal transplant surgery at the Massachusetts General Hospital, where he was recognized as the top teaching fellow in the Partners system. His clinical interests include kidney transplantation, laparoscopic donor nephrectomy, dialysis access surgery, and general surgery in patients with kidney and liver failure. Dr. Nitender Goyal is a nephrologist specializing in kidney and pancreas transplantation, living kidney donation, highly sensitized kidney transplant recipients and kidney paired exchange. He completed his training at B.J Medical College in India, Steward ...
Approximately 17,000 kidney transplants occur each year in the United States, accounting for almost 60% of all organ transplants. Kidney transplantation is the treatment of choice for end stage renal disease. Causes of renal failure are varied, including diabetes, hypertension, glomerular and cystic kidney diseases, and autoimmune disorders. Kidney transplantation offers a better quality of life and a survival benefit for most patients. The 2012 Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR) annual report showed that the conditional graft half-life (defined as the time to when half of the grafts surviving at least one year are still functioning) was 12.5 years for deceased donor transplants and 15.3 years for living donor transplants in 2009-2010. Survival rates continue to improve; a recent analysis of more than 250,000 kidney transplant recipients demonstrated that death-censored graft half-life for all deceased donor transplants increased
Background. Chronic allograft nephropathy (CAN) is the leading cause of late allograft failure, with only limited treatment options. Blockade of the renin-angiotensin system (RAS) decreases progression in diabetic and non-diabetic renal disease, but the effect on CAN is as yet unclear. Therefore, we have studied retrospectively the effect of RAS blockade on renal survival in patients with biopsy-proven CAN.. Methods. The medical records of 72 patients with biopsy-proven CAN were evaluated with regard to time course of graft function, proteinuria, blood pressure, and antihypertensive and immunosuppressive treatment. Coxs proportional hazards model was used for analysing renal graft survival after the index biopsy.. Results. On univariate analysis, histological determinants influencing renal survival were the chronic interstitial and chronic tubular score, and clinical parameters were the serum creatinine level at the time of the biopsy, the relative change in serum creatinine level between 12 ...
BACKGROUND: Chronic transplant dysfunction is characterized by a gradual decline in renal function with slowly rising serum creatinine. The underlying mechanism is thought to include inflammation and atherosclerosis. C-reactive protein (CRP) is a well-established marker of both inflammation and atherosclerosis. In this prospective study, we investigated whether CRP could be of use as a clinical marker for early identification of renal transplant recipients at increased risk of deterioration of graft function. METHODS: In this prospective study, all participating patients (n = 606) visited the out-patient clinic at least once a year, and serum creatinine was assessed at every visit. Subjects with a follow-up of |1 year (n = 31) were excluded from analysis. RESULTS: A total of 575 patients participated at a median (interquartile range) time of 5.9 (2.6-11.3) years post-transplantation. Median time of follow-up was 3.0 (2.4-3.4) years. Changes in serum creatinine during follow-up were -0.45 (-4.83-4.76)
Over a period of two years thirty five renal allograft recipients & donors were evaluated to find out the aetiology of early renal allograft dysfunction, in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from March 2010 to February 2012. A comparison was made between dysfunction & functioning graft group. Mean age of recipients were (36.4±9.4) years, mean age of donors were (41.7±8.3) years, with a male and female ratio of 3:1. Fifty percent recipients showed one heliotype match, ninety percent recipients were anti CMV antibody IgG positive, few were anti CMV antibody IgM positive. All kidney transplant recipients received same immunosuppressive drugs. Primary disease of the renal allograft recipients demonstrates that majority 88.58% had glomerulonephritis, 5.72% had polycystic kidney disease, 2.85% had chronic pyelonephritis and another 2.85% had diabetic nephropathy. Among 35 renal allograft recipients 23(66%) showed early graft dysfunction, ...
Background Calcineurin inhibitor (CNI) therapy is known to induce nephrotoxicity in a dose-dependent manner. Nevertheless, improvements in graft function following elimination or reduction of CNI exposure in long-term kidney transplant recipients remains unclear. Furthermore, benefits of conversion from CNI to mammalian target of rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain. The current study addressed this hypothesis.
Renal transplantation immunology - Vaccination after transplantation - Kidney transplantation: the surgery - Immunosuppressive therapy in renal transplant patients - Diagnosis and treatment of transplant rejection - Suggested renal transplant recipient discharge follow-up - Recurrent and de novo renal disease following renal transplantation - Urinary tract infection post-transplantation - New onset diabetes after transplantation - Infection post-transplantation - Malignancy following renal transplantation - Graft survival in transplant recipients ...
DGFi is Quarks second product candidate to enter clinic trials that is systemically administered to patients. The first ever siRNA drug candidate to be delivered systemically in man was Quarks AKIi-5 which is in Phase I clinical trial for acute kidney injury.. The Phase I/II will be a multi center study in which the safety and tolerability of escalating doses of DGFi by a single IV injection in renal transplant patients with DGF. Up to 204 adult kidney transplant recipients will be enrolled in this 2-part study.. We are pleased with the FDA acceptance of our DGFi IND application for prevention of delayed graft function, which is a very serious medical issue for kidney transplant patients said Shai Erlich, Ph.D., Chief Development Officer of Quark. This is an important milestone for us. It marks Quarks third clinical program and the second in which our siRNA drug is administered systemically to patients. This achievement provides further validation of Quarks RNAi based drug discovery ...
Expanded criteria donors (ECDs) and donation after cardiac death (DCD) provide more kidneys in the donor pool. However, the financial impact and the long-term benefits of these kidneys have been questioned. From 1998 to 2005, we performed 271 deceased donor kidney transplants into adult recipients. …
Abstract of Paper: STUDY OF POST-TRANSPLANT DIABETES MELLITUS IN LIVE - DONOR KIDNEY TRANSPLANT RECIPIENTS , Author: El-Metwally El-Shahawy MD, Sameh Bahgat MD, Hassan Galal MD, Amro Afifi MD, Ashraf Talaat MD, Ehab Wahba Wafa MD* and Ayman Fathi MD* , Year: 2005 , Faculty of Medicine, Benha University
BACKGROUND: Calcineurin inhibitors (CNIs) reduce short-term kidney transplant failure, but might contribute to transplant failure in the long-term. The role of alemtuzumab (a potent lymphocyte-depleting antibody) as an induction treatment followed by an early reduction in CNI and mycophenolate exposure and steroid avoidance, after kidney transplantation is uncertain. We aimed to assess the efficacy and safety of alemtuzumab-based induction treatment compared with basiliximab-based induction treatment in patients receiving kidney transplants. METHODS: For this randomised trial, we enrolled patients aged 18 years and older who were scheduled to receive a kidney transplant in the next 24 h from 18 transplant centres in the UK. Using minimised randomisation, we randomly assigned patients (1:1; minimised for age, sex, and immunological risk) to either alemtuzumab-based induction treatment (ie, alemtuzumab followed by low-dose tacrolimus and mycophenolate without steroids) or basiliximab-based induction
Background. Benefits of conversion from calcineurin inhibitor (CNI) to mammalian target of rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain. Methods. ASCERTAIN was a 24-month, open-label, multicenter study. Kidney transplant patients more than 6 months posttransplant receiving CNI (baseline glomerular filtration rate [GFR] 30-70 mL/min/1.73 m(2)) were randomized to everolimus with CNI elimination (n = 127) or CNI minimization (n = 144), or continued CNI unchanged (controls, n = 123) to assess the effect on measured GFR at month 24 after randomization. Results. Renal function was stable in all groups to month 24. Mean measured GFR at month 24, the primary endpoint, was 48.0 +/- 22.0 mL/min/1.73 m(2), 46.6 +/- 21.1 mL/min/1.73 m(2), and 46.0 +/- 20.4 mL/min/1.73 m(2) in the CNI elimination, CNI minimization, and control groups, respectively. Differences between CNI elimination (1.12 mL/min/1.73 m(2), 95% confidence interval [CI] -3.51 to 5.76, ...
BACKGROUND: The traditional method for assessing HLA antibodies in recipient serum samples is the complement-dependent cytotoxicity testing (CDC). Recently, the highly sensitive microbead-based Luminex assay was introduced and can detect low levels of anti-HLA Abs.. OBJECTIVE: To determine the impact of pretransplant donor-specific HLA antibodies (DSA) detectable by Luminex, despite a negative CDC crossmatch, on the outcomes of kidney transplantation. The correlation and cut-off value of panel reactive antibody (PRA) and DSA was also evaluated.. METHODS: Pre-transplant sera from 116 kidney transplant recipients with a negative CDC crossmatch were assessed for donor-specific HLA antibodies by using Luminex single antigen beads. The patients received kidney transplants at Ramathibodi Hospital between January 2003 and December 2007. The results were correlated with kidney graft outcomes.. RESULTS: DSA were found in 24.1% (28/116) of all recipients. Of the twenty-eight DSA positive patients, four ...
Sellarés, J., Reeve, J., Loupy, A., Mengel, M., Sis, B., Skene, A., de Freitas, D. G., Kreepala, C., Hidalgo, L. G., Famulski, K. S. and Halloran, P. F. (2013), Molecular Diagnosis of Antibody-Mediated Rejection in Human Kidney Transplants. American Journal of Transplantation, 13: 971-983. doi: 10.1111/ajt.12150 ...
TY - JOUR. T1 - Isometric tubular epithelial vacuolization in renal allograft biopsy specimens of patients receiving low-dose intravenous immunoglobulin for a positive crossmatch. AU - Haas, Mark. AU - Sonnenday, Christopher J.. AU - Cicone, Jeffrey S.. AU - Rabb, Hamid. AU - Montgomery, Robert A.. PY - 2004/8/27. Y1 - 2004/8/27. N2 - Background. Perioperative treatment with plasmapheresis and intravenous immunoglobulin (IVIG), combined with a tacrolimus-based immunosuppressive regimen, has been used successfully to allow renal transplantations in crossmatch-positive recipients. A common finding in biopsy specimens of these allografts is isometric vacuolization of proximal tubular epithelium. This finding presents a diagnostic dilemma because it may occur secondary to IVIG treatment or tacrolimus nephrotoxicity. Methods. We compared the frequency and severity of isometric tubular vacuolization in renal allograft biopsy specimens obtained during the first 10 days after transplantation in 24 ...
Live Donor Kidney Transplantation: Updates in Paired Kidney Exchange Miguel Tan, MD, FRCSC Surgical Director, Kidney & Pancreas Transplantation Piedmont Transplant Institute Outline 1. 2. 3. Current statistics for kidney transplantation in the United States Living donor outcomes Paired exchange, impact, logistics and challenges Patients on the waiting list on December 31 of the year (active listings only) Organ supply continues to be a problem in kidney transplantation Almost 100 000 patients on waiting list Average waiting time to transplant 4- 5 years 4% of potential recipients die while waiting on list annually Transplants performed during the year (adult & pediatric combined) Deceased kidney donation rates Organ discard rate for organs recovered for transplantation Possible reasons for lack of growth of supply include -lack of education on donation options ie. living donation, paired exchange, desensitization -Increasing rate of morbid obesity and diabetes resulting poorer quality of organs ...
TY - JOUR. T1 - There are no differences in pretransplant characteristics of individuals receiving simultaneous pancreas-kidney transplant and individuals with type 1 diabetes mellitus receiving living-related kidney transplant. AU - Donigan, L.. AU - Stevens, R. B.. AU - Wrenshall, L.. AU - Larsen, J.. PY - 2004/5. Y1 - 2004/5. N2 - Abstract Simultaneous pancreas-kidney transplantation (SPK) recipients have longer survival compared to type 1 diabetes mellitus (DM1) cadaveric kidney recipients. However, DM1 living-related kidney transplant (KTX-LR) recipients have the same mortality as SPK recipients. It is unknown whether cardiovascular (CVD) risk factors pretransplant are similar between the two groups, SPK and DM1 KTX-LR. We analyzed pretransplant characteristics of SPK recipients (n = 39) and DM1 KTX-LR/living unrelated (LUR) recipients (KTX-LR/LUR, n = 20). In individuals who had multiple transplants, only pretransplant data from the first transplant was used. As all characteristics of ...
The purpose of this review was to investigate this in more detail-in particular the choice between a simultaneous pancreas-kidney transplantation and
Objective. In kidney transplanation, some upper pole branches are too thin to be reconstructed. The impact of graft thin upper pole arterial branch ligation on adult living donor kidney transplantation remains to be investigated. Methods. Between January 2008 and May 2015, 604 adult living donor kidney transplants were performed. 462 kidney grafts with single arteries (Single artery group), 125 kidney grafts with reconstructed arteries (Reconstruction group), and 17 kidney grafts with ligated thin upper pole arterial branch (Ligation group) were enrolled. To evaluate the efficacy of thin upper pole ligation, Ligation group was compared with other groups. Characteristics of donors, recipients, and operation, recipient eGFR, and complications were investigated.. Results. Warm ischemic time and total ischemic time were significantly longer in Reconstruction group ...
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with CMV-infection being the most important viral infection with adverse impact on patient and allograft outcomes. A comparison of CMV-infection between SPKTRs and kidney transplant recipients (KTRs), and the association of CMV-infection with other infectious complications in SPKTRs, however, remains scarcely described.. Here, we studied all primary SPKTRs and primary deceased-donor KTRs (,65 years) at our transplant center between 2008 and 2015 for the development of active CMV-infection. 21 of 62 SPKTRs (33.9%) and 90 of 335 KTRs (26.9%) were diagnosed with CMV viremia. A control group of 41 SPKTRs without CMV viremia was used for comparison.. SPKTRs showed an increased incidence of active CMV-infection compared to KTRs. SPKTRs were more likely to develop CMV-disease, CMV pneumonia, recurrent CMV-infection, higher initial and peak CMV-loads, and more need for intravenous antiviral therapy compared to KTRs ...
Laparoscopic living donor kidney transplantation. Laparoscopic nephrectomy for kidney transplant has been established as a mainstream procedure both in Europe and the US because it allows donors to resume their daily activities very quickly.. In 2015 we performed the first laparoscopic living donor kidney transplant in a male patient following laparotomy. This 68-year-old patient had previously undergone surgery due to a car accident. Two 5mm trocars and one 10mm trocar were placed on the left midclavicular line, from the costal arch towards the anterior superior iliac spine and, a 10 mm trocar has been placed in the suprapubic area, which was replaced by a gelport for transplant removal.. Surgery lasted three hours. Warm ischemia time was three minutes.. The graft was immediately placed and the recipient had immediate diuresis with beginning of the renal function.. The postoperative course of the donor was unhindered and he was discharged from hospital on the fourth postoperative day.. The ...
We are a leading center for living donor kidney transplant and incompatible blood type kidney transplant in adult and pediatric kidney transplant patients.
Live donor kidney transplantation has become a widely sought treatment by patients with end-stage renal failure. As the outcome for the genetically and emotionally related live donor transplants is the same, this review considers live kidney transplantation from the broad scope of current international practice. Unrelated live donor transplantation can now be performed for incompatible donor recipient pairs via a simultaneous paired kidney donation. However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. At a recent World Health Organization (WHO) conference of Middle East transplant professionals a statement of unequivocal opposition to commercialism was drafted. In the United States, the Institute of Medicine has recently published a significant report that affirms the legal prohibition of organ sales. These documents are in ...
TY - JOUR. T1 - Long-term kidney allograft function and survival in prednisone-free regimens. T2 - Tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus. AU - Chhabra, Darshika. AU - Skaro, Anton I.. AU - Leventhal, Joseph R.. AU - Dalal, Pranav. AU - Shah, Gaurav. AU - Wang, Edward. AU - Gallon, Lorenzo. PY - 2012/3/1. Y1 - 2012/3/1. N2 - Background and objectives: The optimal maintenance immunosuppressive regimen to improve long-term renal allograft function and graft survival is yet to be determined. Design, setting, participants, & measurements: This observational study prospectively compared tacrolimus/sirolimuswith tacrolimus/mycophenolatemofetil in renal transplant recipients using a prednisone-free regimen with over 8.5 years of follow-up. Patients received methylprednisonlone and anti-IL2 receptor antagonist (Basiliximab) induction and were blindly randomized to either the tacrolimus/mycophenolate mofetil (n=45) or tacrolimus/sirolimus (n=37) groups. Outcomemeasures included ...
TY - JOUR. T1 - Urine proteomic profiling for biomarkers of acute renal transplant rejection.. AU - Liang, Shu Ling. AU - Clarke, William. PY - 2010. Y1 - 2010. N2 - Acute allograft rejection is a serious impediment to long-term success in renal transplantation. Early detection of rejection is crucial for treatment of rejection, and can help avoid long-term effects such as chronic rejection or loss of the transplanted organ. The current diagnostic paradigm is a combination of clinical presentation, biochemical measurements (serum creatinine), and needle biopsy. There are significant efforts underway to find alternate biomarkers for early detection of acute rejection, including protein profiling of urine by mass spectrometry. One approach for protein profiling is to use affinity mass spectrometry - we describe a method for this using ProteinChips and SELDI-TOF mass spectrometry.. AB - Acute allograft rejection is a serious impediment to long-term success in renal transplantation. Early detection ...
The development of the meeting and workgroups, rationale for the topics, process of creating consensus, and top recommendations are outlined in more detail in an overview meeting report (3). Recommendations included strategies to educate patients with CKD and ESRD, potential living donors, and the public; efficiencies in processes; policy initiatives; and a research agenda. An important and recurring theme was the importance of coordination and communication between providers throughout the continuum of disease to most effectively reach patients and their support systems. This moving points edition will address consensus conference recommendations for a collaborative approach to care, education, and access to improve overall practice in LDKT and LKD.. Five articles address how transplant centers and community nephrology care teams can partner for improved practices. In the first article, Living Donor Kidney Transplantation: Improving Education Outside of Transplant Centers about Live Donor ...
Slow graft function after pediatric renal transplantation from volunteer live donors , Slow graft function after pediatric renal transplantation from volunteer live donors , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
Mesenchymal stem cells (MSCs) are multi-potent non-hematopoietic progenitor cells possessing an immune-regulatory function, with suppression of proliferation of activated lymphocytes. In this study, adult living donor kidney transplantation (LDKT) recipients were given MSCs derived from the donor bone marrow to evaluate the safety and the feasibility of immunological changes related to the intra-osseous injection of MSC into the bone marrow. MSCs were derived from negative HLA cross-match donors. Donor bone marrow was harvested 5 weeks prior to KT. At the time of transplantation, 1 x 106 cell/kg of donor MSC was directly injected into the bone marrow of the recipients right iliac bone. Patients clinical outcomes, presence of mixed chimerism by short tandem repeat polymerase chain reaction, analysis of plasma FoxP3 mRNA and cytokine level, and mixed lymphocyte reaction (MLR) were performed. Seven patients enrolled in this study and received donor MSC injections simultaneously with LDKT. The median age
Compared with kidney transplantation alone, simultaneous pancreas-kidney (SPK) transplantation was associated with an almost twofold lower 10-year mortality among type 1 diabetics, in a retrospective study.. The study included all 2,796 patients with type 1 diabetes in the Netherlands who started renal replacement therapy or received a first kidney transplant between 1986 and 2016. As reported in Diabetes Care, of the 996 who received new kidneys, 42% received a deceased-donor kidney; 16%, a living-donor kidney; and 42%, an SPK transplant. Crude survival was highest in SPK recipients and lowest in recipients of a deceased-donor kidney. Median survival time was 7.3 years for deceased-donor kidney recipients; 10.5 years for living-donor kidney recipients; and 16.5 years for SPK recipients.. @media (min-width:500px){#social{padding:0 0 15px 67px}#link{display:none!important}#facebook{padding:0 29px 0 24px}}@media screen and ...
A living donor kidney transplant takes an organ from a living donor and transplants it to the recipient. Learn more about living kidney donation here.
A living donor kidney transplant takes an organ from a living donor and transplants it to the recipient. Learn more about living kidney donation here.
TY - JOUR. T1 - The Association of 25-Hydroxyvitamin D Levels with Late Cytomegalovirus Infection in Kidney Transplant Recipients. T2 - The Wisconsin Allograft Recipient Database. AU - Astor, Brad C.. AU - Djamali, Arjang. AU - Mandelbrot, Didier A.. AU - Parajuli, Sandesh. AU - Melamed, Michal L.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background. Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in kidney transplant recipients. Vitamin D has an integral role in proper immune function, and deficiency is common among kidney transplant recipients. It remains unclear whether 25-hydroxyvitamin D [25(OH)D] level is associated with CMV infection in kidney transplant recipients. Methods. We examined the relationship between 25(OH)D levels, measured at least 6 months posttransplant, and subsequent CMV infection in 1976 recipients free of prior CMV infection. Results. Of 1976 recipients, 251 (12.7%) were vitamin D deficient [25(OH)D ,20 ng/mL] and 548 (27.7%) were insufficient ...
Ethics of Living Donor Kidney Transplantation Interviewer: Quentin Cooper Interviewees: Mr Andrew Ready, Trustee and Lead Surgeon of TLC, Dr Shazia Shabir, Consultant Nephrologist at University Hospitals Birmingham and TLC volunteer, and Dr Dwomoa Adu, Consultant Nephrologist at Korle Bu Hospital, Accra, Ghana, and TLC Trustee Welcome to this TLC podcast in which science journalist,…
Understand more about why beliefs about organ donation within different communities may impact on decisions about living donor kidney transplantation amongst people from different ethnic backgrounds.. ...
TY - JOUR. T1 - Effects of dipeptidyl peptidase-4 inhibitors on hyperglycemia and blood cyclosporine levels in renal transplant patients with diabetes. T2 - A pilot study. AU - Bae, Jaehyun. AU - Lee, Min Jung. AU - Choe, Eun Yeong. AU - Jung, Chang Hee. AU - Wang, Hye Jin. AU - Kim, Myoung Soo. AU - Kim, Yu Seun. AU - Park, Joong Yeol. AU - Kang, Eun Seok. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Background: The use of dipeptidyl peptidase-4 (DPP-4) inhibitors is increasing among renal transplant patients with diabetes. However, the glucose-lowering efficacies of various DPP-4 inhibitors and their effects on blood cyclosporine levels have not been fully investigated. We compared the glucose-lowering efficacies of DPP 4 inhibitors and evaluate their effects on the blood levels of cyclosporine in renal transplant recipients with diabetes. Methods: Sixty-five renal allograft recipients who received treatment with DPP-4 inhibitors (vildagliptin, sitagliptin, or linagliptin) following kidney transplant ...
Background: Kidney transplant (Tx) patients present a reduced cardiovascular (CV) mortality in comparison to the dialysis population, but in comparison to the general population, it is still several-fold higher. Methods: We studied risk factors for CV disease in a group of 38 patients (50% males, median age 36 years) who underwent a living donor Tx at the baseline and after 3 ± 1 and 9 ± 2 months. Results: The prevalence of overweight increased from 26 to 54% after Tx (p | 0.001). The mean systolic blood pressure decreased significantly after the Tx (148 ± 27.6 vs. 126 ± 12.7 mm Hg). There was a significant increase in LDL (97 ± 30 vs. 114 ± 35) and hematocrit (33.8 ± 4.4 to 42 ± 5.7%) levels and a significant reduction in fibrinogen levels (394 ± 91 vs. 366 ± 100 mg/dl) after 9 months as compared to the baseline. Obesity and dislipidemia were significantly correlated with inflammation. Significant changes in left ventricle mass index (293 ± 116 vs. 241 ± 96) were observed after the Tx.
TY - JOUR. T1 - Association of prevalent vascular disease with allograft failure and mortality in live-donor kidney transplant recipients - a retrospective cohort study. AU - Mainra, Rahul. AU - Wong, Germaine. AU - Pilmore, Helen. AU - Lim, Wai H.. PY - 2019/6/26. Y1 - 2019/6/26. N2 - Limited data exist regarding the impact of prevalent vascular disease after live-donor kidney transplantation. We aimed to determine the associations between the number of prevalent vascular diseases, allograft, and patient outcomes following live-donor transplantation. This cohort study used data from the Australia and New Zealand Dialysis and Transplant Registry. Rates between recipients of live-donor kidney transplants ± prevalent vascular disease prior to transplantation were calculated. The associations between vascular disease, allograft failure, and all-cause mortality were assessed using Cox regression modeling. Kaplan-Meier proportions were used to calculate all-cause mortality and death with a function ...
TY - JOUR. T1 - Sero-molecular evaluation of human cytomegalovirus disease in renal transplant rejection.. AU - Kishore, Janak. AU - Mukhopadhyay, Chiranjoy. AU - Savitri, AU - Ayyagari, Archana. AU - Sharma, Rakesh Kumar. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Cytomegalovirus (CMV) is the most common viral pathogen in renal transplant recipients resulting in graft rejection. The prevalence of CMV disease and renal graft rejection is not well studied in India. Sequential specimens from 32 renal allograft recipients were examined by using CMV IgM specific mu capture ELISA and DNA by PCR. Twelve of the 32 patients were CMV IgM positive and out of 12 patients, 9 had rejection and 4 experienced CMV disease. CMV IgM specific mu capture ELISA helped in diagnosis of CMV disease, though it is less sensitive in detection of rejection. PCR itself was proved not sensitive enough in detecting either CMV disease or rejection. At present, optimal laboratory detection of CMV infection in these patients can be ...
TY - JOUR. T1 - Use of Ultrasound and Cystoscopically Guided Pancreatic Allograft Biopsies and Transabdominal Renal Allograft Biopsies. T2 - Safety and Efficacy in Kidney-Pancreas Transplant Recipients. AU - Kuhr, Christian S.. AU - Davis, Connie L.. AU - Barr, Darlene. AU - McVicar, John. AU - Perkins, James D.. AU - Bachi, Carlos E.. AU - Alpers, Charles E.. AU - Marsh, Christopher L.. PY - 1995. Y1 - 1995. N2 - The use of allograft biopsies to guide treatment after solid organ transplantation is a valuable tool in the detection and treatment of rejection. Prior development and use of the cystoscopically guided pancreatic allograft biopsy have allowed for more accurate and timely diagnosis of pancreatic allograft dysfunction, possibly contributing to our 1-year pancreas graft, renal allograft and patient survival rates of 87.1%, 88.5% and 96.8%, respectively. We reviewed our experience, examining efficacy and complication rates of pancreas and kidney biopsies in 31 cadaveric pancreas or ...
Pre-transplant nephrectomy is performed to reduce risks to graft and recipient. The aims of this study were to evaluate (1) indications, surgical approach, and morbidity of native nephrectomy and (2) the effects of kidney removal on clinical and biological parameters. This study was designed as a single-center retrospective cohort study in which 49 consecutive patients with uni- or bilateral native nephrectomies were identified from a total of 126 consecutive graft recipients in our pediatric kidney transplantation database between 1992 and 2011. Demographic, clinical, and laboratory details were extracted from charts and electronic records, including operation reports and pre- and post-operative clinic notes. Of the 49 nephrectomized patients, 47% had anomalies of the kidneys and urinary tract, 22% had cystinosis, 12% had focal segmental glomerulosclerosis, and 6% had congenital nephrotic syndrome. Nephrectomy decisions were based on clinical judgment, taking physiological and psychosocial aspects into
Chronic renal transplant rejection is a form of renal transplant rejection. It usually later following transplantation. Pathology Chronic rejection is defined as a gradual deterioration in graft function beginning at least 3 months after transp...
The Lorma Kidney Transplant Center provides personalized, holistic and best possible care to kidney transplant patients and their family. Our team is dedicated to make the entire kidney transplant process more convenient and less stressful for the patient. It has a multidisciplinary team composed of our best health care professionals who utilize evidence based practices and state-of-the-art diagnostic and surgical equipment.. Kidney Transplant: The best option for end-stage. Most often, kidney transplantation is the best treatment option for patients with chronic and end-stage renal disease. A kidney transplant is an operation that places a healthy kidney in the body. The transplanted kidney takes over the work of the two kidneys that failed and dialysis is no longer needed. Often,the new kidney will start making urine as soon as blood starts flowing through it. A successful kidney transplant affords a new beginning for ESRD patients because it offers enhanced quality and duration of ...
The ICAVL guidelines for transplant renal artery duplex ultrasound are similar to those for native arteries, with variations that include the need to examine the peri-transplant region with gray scale images, the arterial anastomosis with spectral Doppler waveforms and velocity measurements and the venous anastomosis with spectral Doppler waveforms. It should be noted that as external iliac artery stenosis can result in impaired blood flow to the transplanted kidney, this artery should also be interrogated as part of a complete examination.. Furthermore, it should be noted that transplant renal arteries have two characteristics that may cause elevated peak systolic velocity without stenosis. First, an end to side anastomosis may cause a local tortuosity and second, a transplant kidney tends to undergo hypertrophy and may be supplied by a higher than normal blood volume. Also, there is large normal variability of peak systolic velocity in transplant renal arteries.. Published peak systolic ...
were present in biopsies from patients with subclinical rejection and largely absent in normal protocol biopsies. Transcripts for perforin, Fas ligand, and granzyme B were also present in patients with subclinical rejection, although in reduced amounts when compared to biopsies from patients with clinical rejection episodes. There were no differences in IL-10 and IL-15 transcripts in clinical and subclinical rejection biopsies. Additional, albeit indirect, data in favor of a pathogenic role for subclinical rejection comes from the early observation of Isoniemi et al, who reported that in patients who had not experienced clinical acute rejection episodes, the development of chronic histological changes occurred in inverse relation to the amount of immunosuppression they had received.15 Similarly, Legendre et al reported a patient cohort that never experienced clinical rejection episodes, in whom the development of chronic rejection at 2 years was preceded by subclinical rejection at three ...
TY - JOUR. T1 - Pilot Study. T2 - Association of Traditional and Genetic Risk Factors and New-Onset Diabetes Mellitus Following Kidney Transplantation. AU - Chakkera, H. A.. AU - Hanson, R. L.. AU - Raza, S. M.. AU - DiStefano, J. K.. AU - Millis, M. P.. AU - Heilman, R. L.. AU - Mulligan, D. C.. AU - Reddy, K. S.. AU - Mazur, M. J.. AU - Hamawi, K.. AU - Moss, A. A.. AU - Mekeel, K. L.. AU - Cerhan, J. R.. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2009/12. Y1 - 2009/12. N2 - Introduction: New-onset diabetes mellitus, which occurs after kidney transplant and type 2 diabetes mellitus (T2DM), shares common risk factors and antecedents in impaired insulin secretion and action. Several genetic polymorphisms have been shown to be associated with T2DM. We hypothesized that transplant recipients who carry risk alleles for T2DM are tipped over to develop diabetes mellitus in the posttransplant milieu. Methods: We investigated the association of genetic and traditional ...
The nations first kidney transplant from a living HIV-positive donor to another HIV-positive person was successfully performed Monday by doctors at a
Recurrence of hemolytic uremic syndrome after renal transplantation in children: a report of the North American Pediatric Renal Transplant Cooperative Study. Quan A, Sullivan EK, Alexander SR. Transplantation 2001;72(4):742-745.. ABSTRACT:. Hemolytic uremic syndrome (HUS) is a leading cause of renal failure in children. Although 90% of children with typical or classic HUS (associated with E. coli O157:H7) fully regain normal renal function, 5% die and 5% develop end-stage renal disease (ESRD) and require subsequent dialysis and renal transplantation. Among HUS renal transplant recipients, the incidence of recurrence of HUS in renal allografts has varied from 0% to 50%. Atypical HUS, use of cyclosporine, and early transplantation after HUS are possible risk factors. This report reviews the data from 61 (54%) of 114 HUS patients within the North American Pediatric Renal Transplant Cooperative Study registry who have had a transplant. Of these 61 patients, 5 patients (with 6 renal transplants) ...
Findings from this review may have implications for policies and practices related to living kidney donation. For example, donors should be informed that, although nephrectomy is associated with a higher RR for ESRD,the absolute risk is still low for most donors (that is, those not from known high-risk populations [39]). Thus, risk prediction tools for ESRD may better approximate the risks involved for prospective donors (43). Guidelines that do not contain information about pregnancy for living kidney donors should instead include relevant information for women of childbearing age in the informed consent process. Furthermore, this review supports the need for long-term follow-up of donors to monitor their health and mitigate possible increases in disease risks associated with kidney donation (44). In conclusion, compared with nondonor populations, living kidney donors have no increased risk for several major chronic diseases, with the exception of ESRD. However, the absolute risk for this ...
Severe Hemolytic Anemia Post-Renal Transplantation Produced by Donor Anti-D Passenger Lymphocytes: Case Report and Literature Review Academic Article ...
The expanded criteria donor (ECD) is any donor over the age of 60, or a donor over the age of 50 with two of the following: a history of high blood pressure, a creatinine (blood test that shows kidney function) greater than or equal to 1.5, or death resulting from a stroke.. Sometimes the function of a single kidney from an expanded criteria donor organ would not be sufficient. In this situation, a pair of kidneys with limited function can be transplanted into a single patient. This type of transplant is called a dual kidney transplant. Research shows that this option offers outcomes that are just as good as a single-kidney transplant with normal function and can effectively address the shortage of donor organs.. The transplant center must get written permission from a patient before offering an ECD kidney. The decision to accept an ECD kidney is a personal decision. Accepting an ECD kidney may significantly decrease the amount of time a person waits for transplant. The ECD kidney comes with ...
LIVING DONOR - KIDNEY TRANSPLANT from stewart cheifet on Vimeo.. Kidneys for transplant come from a living donor or a deceased (cadaver) donor. When a kidney is transplanted from a living donor, the donors remaining kidney enlarges to take over the work of two. As with any major operation, there is a chance of complication. But kidney donors have the same life expectancy, general health and kidney function as others.. Any healthy person can safely donate a kidney. The donor must be in excellent health, well informed about transplantation and able to give informed consent. Costs for living donor surgery, hospitalization, diagnostic tests and evaluation usually are paid by the recipients insurance. Travel and living expenses are not covered. Insurance coverage will be discussed during the transplant evaluation.. If you have a potential living donor, he or she will undergo an evaluation and discuss the possibility of organ donation. Tests will be performed to ensure that the donor and recipient ...
Eculizumab: This humanized monoclonal antibody against complement C5 ultimately prevents the formation of C5-9 membrane attack complex and generation of prothrombotic C5a.. Plasma exchange: Plasma exchange can be used to remove the mutated protein and replace them with normal proteins in patients who do not respond to Eculizumab. Transplant patients with auto-antibodies against complement factor H have been successfully treated with plasma- exchange, rituximab and high dose steroids.. Liver- kidney transplantation: There have been some case reports of combined liver and kidney transplantation, which has been successful in treating HUS in patients with complement factor H mutation.. It is important to identify the gene mutation that led to atypical HUS in every patient who is evaluated for kidney transplantation and has a history of atypical HUS, in order to estimate the risk of recurrence and plan eventual prevention therapy. The knowledge of the mutation would also allow appropriate ...
Dr. H S Bhatyal is a famous Renal Transplant Surgeon & Urologist in Karol Bagh, Delhi who was formerly a Chief Renal Transplant Surgeon at Batra Hospital Medical Research Centre in New Delhi, Chief Renal Transplant Surgeon at Agarsen Hospital in New Delhi, HOD Department of Urology & Renal Transplant at Army Hospital (R&R), HOD Department of Urology at Jaipur Golden Hospital, HOD Department of Urology & Renal Transplant at Batra Hospital, HOD Department of Urology at Escort Hospital in Faridabad, HOD Renal Transplantation Moolchand Medcity in New Delhi, Chairman Renal Transplantation & Urology at Primus Super specialty Hospital in New Delhi and HOD Urology & Renal Transplantation at Asian Institute of Medical Sciences in Faridabad ...
Here, we report that kidney-pancreas and kidney-islet transplants, when successful, prevent the worsening of graft survival and vascular function of the kidney graft that may occur in ESRD diabetic patients receiving kidney transplants. Noninvasive assessments of graft vascular function using RI and UAE evaluations showed that the KP and KI-s groups had better cumulative kidney graft survival at 2, 4, and 6 years than did the KD group. Expression of NOS in the kidney graft correlated well with the functional data, showing an early impairment of NO pathways in the glomerular vessels of KD-transplanted patients. Only the KP transplant group experienced a sustained compensatory hypertrophy of the kidney graft.. The transplanted kidney in ESRD type 1 diabetic patients is exposed to the deleterious effects of both diabetes and immunosuppression (34). Initially, diabetic nephropathy encompasses both functional changes (i.e., reduced renal vasodilatory reserve and reduced ability to respond to ...
The Kidney Transplant Team at the Upstate University Hospital has established written patient selection criteria for kidney transplantation. Selection of patients for kidney transplantation is performed without discrimination based upon race, ethnicity, religion, gender, sexual preference, handicap or national origin.. This selection criteria is administered in accordance with Upstate University Hospitals Patients Rights and Responsibilities policy and the Organ Procurement and Transplantation Network (OPTN) organ allocation policies. The purpose of this page is to outline current criteria that potential transplant candidates must meet in order to be considered for kidney transplantation at the Upstate University Hospital. Kidney transplantation is an evolving field, and consequently, selection criteria may change over time.. ...
TY - JOUR. T1 - Surgical complications in solitary pancreas and combined pancreas-kidney transplantations. AU - Ozaki, Claire F.. AU - Stratta, Robert J.. AU - Taylor, Rodney J.. AU - Langnas, Alan N.. AU - Bynon, J. Steven. AU - Shaw, Byers W.. PY - 1992/11. Y1 - 1992/11. N2 - The benefits of pancreas transplantation (PT) must be weighed against the morbidity associated with the operative procedure and long-term immunosuppression. Over a 32-month period, we performed 73 PTs including 61 combined pancreas-kidney transplants (PKT) and 12 solitary PTs. In the PKT group, 25 reoperations were performed in 18 patients (29.5%) at a mean of 39±12 days after transplant. In the solitary PT group, 16 reoperations were performed in 8 recipients (66.7%, p=0.03) at a mean of 87±12 days after PT (p,0.01). In the PKT group, pancreas allograft survival was 93.4%. Vascular thrombosis resulted in the loss of two pancreas allografts. In the solitary PT group, pancreas allograft survival was 50% (p,0.001), with 6 ...
The incidence of acute rejection at discharge was lower with alemtuzumab but was comparable with IL-2RA up to 1 year posttransplant. There was no difference in patient survival, but the risk of graft loss among patients who received alemtuzumab was higher compared with those who received IL-2RA indu …
Testing Committee There is a new minor antigen gaining attention in the field of human leukocyte antigen (HLA) testing and kidney transplantation: the major-histocompatibility-complex (MHC) class I-related chain A, or MICA antigen. It is classified as a minor antigen because it is not an HLA antigen (ie, HLA-A, HLA-B, etc.). The major reason MICA has become a molecule of interest is related to the natural history of renal allograft survival. While the one-year graft survival rates for living and/or deceased donor kidney transplants are approximately 90%, graft survival rates drop to about 80% at five years and to 50% or less at 10 years. Advances in both immunosuppression and HLA matching, particularly of HLA-A, HLA-B, and HLA-DR antigens, have contributed to improved graft survival and patient survival, especially within the first year. ABO blood group antigen matching has also improved graft survival. However, the long-term graft failure rates still remain a major problem in kidney (and ...
Methods and Results-In a double-blind controlled trial, we randomized 4110 stable kidney transplant recipients to a multivitamin that included either a high dose (n=2056) or low dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocysteine concentrations reduced the rate of the primary composite arteriosclerotic cardiovascular disease outcome (myocardial infarction, stroke, cardiovascular disease death, resuscitated sudden death, coronary artery or renal artery revascularization, lower-extremity arterial disease, carotid endarterectomy or angioplasty, or abdominal aortic aneurysm repair). Mean follow-up was 4.0 years. Treatment with the high-dose multivitamin reduced homocysteine but did not reduce the rates of the primary outcome (n=547 total events; hazards ratio [95% confidence interval]=0.99 [0.84 to 1.17]), secondary outcomes of all-cause mortality (n=431 deaths; 1.04 [0.86 to 1.26]), or dialysis-dependent kidney failure (n=343 events; 1.15 ...
Erythrocytosis generally develops in those renal transplant recipients who have good renal function and without evidence of acute and chronic rejection.1 In our study PTE patients had excellent graft functions, with mean serum creatinine of 1.06±0.29mg/dl at the onset of PTE. At the end of follow up the serum creatinine was 1.00±0.35 mg/dl. Patients with post transplant erythrocytosis in our study had a higher value of acute rejection episodes, which is rather unexpected and contrary to most previous studies showing that PTE occurs in those who had rejection free course before developing erythrocytosis. In 7 out of 13 patients who had acute rejection in PTE group, episode of acute rejection occurred well after development of erythrocytosis suggesting that acute rejection episode was non contributing to erythrocytosis. In remaining 6 patients acute rejection preceded PTE. In all these later patients rejection occurred in early transplant period with good reversal. Their renal functions were ...
Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To evaluate the frequency of CD4+CD25+CD127- and CD3+CD8+CD28- regulatory T cells in chronic allograft dysfunction (CAD) and to investigate the expression of TGF- β1 in renal allografts. Methods: Thirty biopsy-proven CAD patients were pair-matched with 30 stable graft function patients and a third group of healthy volunteers. Flowcytometry was performed on PBMCs to determine the frequency of CD3+CD8+CD28- and CD4+CD25+CD127- regulatory T cells in lymphocyt population. TGF- β1 gene expression was assessed by Real Time PCR. Results: The percentage of CD3+CD8+CD28- Tregs among renal allograft recipients was higher than
FK506 Kidney Transplant Study Group". Transplantation. 63 (7): 977-83. doi:10.1097/00007890-199704150-00013. PMID 9112351. ... and cyclosporine for immunosuppression after cadaveric renal transplantation. ...
"Ureteral stenosis after kidney transplantation". Transplant International. 12 (5): 334-340. doi:10.1007/s001470050236. ISSN ... A kidney stone can move from the kidney and become lodged inside the ureter, which can block the flow of urine, as well as ... The affected kidney could then develop hydronephrosis, should a part of the kidney become swollen due to blocked flow of urine ... These animals possess an adult kidney derived from the metanephros. The duct that connects the kidney to excrete urine in these ...
Saudi Journal of Kidney Diseases and Transplantation. 24 (5): 938-41. doi:10.4103/1319-2442.118087. PMID 24029258. von Moos, R ... kidney failure. Gastrointestinal or systemic, such as celiac disease and non-celiac gluten sensitivity (both often occur ...
Once kidney failure has developed, patients usually do well on dialysis or with a kidney transplant. Transplantation can rarely ... Saudi Journal of Kidney Diseases and Transplantation. 17 (3): 320-5. PMID 16970251. Pescucci C, Mari F, Longo I, Vogiatzi P, ... To be helpful, kidney biopsies need to be taken before the disease is too advanced. Changes on conventional (light) microscopy ... Progressive loss of kidney function (reflected clinically by increases in serum creatinine or decreases in estimated glomerular ...
Hardinger KL, Brennan DC, Klein CL (July 2013). "Selection of induction therapy in kidney transplantation". Transplant ...
"Laparoscopic Kidney Transplantation by George P. Abraham". YouTube video. Kairali TV. 18 July 2012. Retrieved 9 June 2016. v t ...
"The role of Thymoglobulin induction in kidney transplantation: an update". Clinical Transplantation. 26 (5): E450-E464. doi: ... use of ALG for preserving short-term and long-term kidney function in patients immediately after human kidney transplantation. ... especially kidney, liver, pancreas, and heart transplantation. As multiple studies have demonstrated both its efficacy and ... "Selection of induction therapy in kidney transplantation". Transplant International. 26 (7): 662-672. doi:10.1111/tri.12043. ...
ISBN 3-540-00878-0. Hardinger KL, Brennan DC, Klein CL (July 2013). "Selection of induction therapy in kidney transplantation ... It is used to prevent rejection in organ transplantation, especially in kidney transplants. Basiliximab is an immunosuppressant ... agent used to prevent immediate transplant rejection in people who are receiving kidney transplants, in combination with other ...
Kidney Transplantation, Bioengineering and Regeneration, Academic Press: 223-234, doi:10.1016/B978-0-12-801734-0.00017-5, ISBN ... "Improved flow cytometry crossmatching in kidney transplantation". HLA. 92 (6): 375-383. doi:10.1111/tan.13403. ISSN 2059-2310. ... CDC assays are used to find a suitable donor for organ or bone marrow transplantation, namely donor with matching phenotype of ...
... kidney) Ponticelli, C.; Moroni, G. (2005-01-01). "Renal transplantation in lupus nephritis". Lupus. 14 (1): 95-98. doi:10.1191/ ... The diagnosis of lupus nephritis depends on blood tests, urinalysis, X-rays, ultrasound scans of the kidneys, and a kidney ... Saudi Journal of Kidney Diseases and Transplantation. 25 (3): 539-43. doi:10.4103/1319-2442.132169. PMID 24821149. Karageorgas ... Kidney failure is very rare in this form. Class II is based on a finding of mesangial proliferative lupus nephritis. This form ...
January 2016). "Belatacept and Long-Term Outcomes in Kidney Transplantation". The New England Journal of Medicine. 374 (4): 333 ... "FDA approves Nulojix for kidney transplant patients" (Press release). U.S. Food and Drug Administration. 2011-06-15. Archived ...
Chronic Kidney Disease, Dialysis, and Transplantation (Fourth Edition). Elsevier: 450-469.e6. doi:10.1016/b978-0-323-52978- ...
Lerma, Edgar; Rosner, Mitchell (2012-10-28). Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. ... As the kidneys inflame, they begin to excrete needed protein from the affected individual's body into the urine stream. This ... "Pyelonephritis: Kidney Infection". Retrieved 2015-06-14. "Lupus Nephritis". Retrieved ... Treatment (or management) of nephritis depends on what has provoked the inflammation of the kidney(s). In the case of lupus ...
Living donor kidney transplantation in a global environment. Kidney Int. 2007 7:608-14. Dew MA, Jacobs CL, Jowsey SG, Hanto R, ... Outcome of kidney transplantation using expanded criteria donors and donation after cardiac death kidneys: realities and costs ... He is a member of the Editorial Board of Transplantation, Kidney International and Clinical Transplantation. Delmonico has ... Impact of donor kidney recovery method on lymphatic complications in kidney transplantation. Transplant Proc. 2008 40(4):1054-5 ...
Marino is working with the Noble Laureate Alvin Roth to implement a new method aimed at increasing kidney transplantation. ... He is also a member of the Editorial Board of Transplantation, Liver Transplantation, Clinical Transplantation, and 9 other ... Norman, SP; Kommareddi, M; Kaul, DR (July-September 2012). "Update on kidney transplantation in HIV-infected recipients". AIDS ... Pittsburgh was then by far the most active Liver transplantation center in the world: for example, in 1990-1991 alone, more ...
"Pulitzer-Winning Pittsburgh Press Story on Kidney Transplantation". Photo Archives of the Pittsburgh Post-Gazette. September 5 ... began publishing the 13-article series in November 1985 after 10 months of investigation into the United States's kidney ...
Kidney transplantation pioneer in the Caribbean and Latin America. Early proponent of Viagra. Michael Woodruff, transplantation ... Claudius Amyand, performed the first Appendicectomy Christiaan Barnard, cardiac surgery, first heart transplantation William ...
He performed the first cadaver Kidney transplantation in Karnataka. In 2005, he was awarded the prestigious Rajyotsava Award by ... Launched free Pediatric Kidney Transplants (Kidney Transplants for children) for disadvantaged sections of the society in the ... "A first in kidney transplant in State". The Hindu. 20 January 2013. "Karnataka / Bangalore News : It is a dream come true". The ... "City-based hospital flags off awareness campaign towards kidney cure - Times of India". The Times of India. "Manipal Health ...
Kosieradzki, M; W Rowinski (December 2008). "Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention ...
Liddle syndrome resolves completely after kidney transplantation. It is named after Dr. Grant Liddle (1921-1989), an American ... These channels are found on the surface of epithelial cells found in the kidneys, lungs, and sweat glands. The ENaC transports ... Brenner and Rector's The Kidney, 8th ed. CHAPTER 40 - Inherited Disorders of the Renal Tubule. Section on Liddle Syndrome. ... Liddle syndrome involves abnormal kidney function, with excess reabsorption of sodium and loss of potassium from the renal ...
... era of kidney transplantation". Journal of Medical Biography. 25 (4): 234-239. doi:10.1177/0967772015608056. PMID 26512065.( ... Marius Renard who damaged his only kidney when he fell off scaffolding, using a kidney donated by the subject's mother. The ... He is particularly known for his contribution to nephrology, and for having performed the first renal transplantation in France ... Together with René Kuss, Hamburger defined the precise methods and rules for conducting renal transplantation surgery and is ...
Joseph Murray performs the first permanent cadaveric kidney transplantation. Nodding disease is first documented, in southern ...
"Successful Transplantation of Kidney Allografts in Sensitized Rats After Syngeneic Hematopoietic Stem Cell Transplantation and ... Significance of the positive crossmatch test in kidney transplantation. N Engl J Med. 1969; 280(14):735-9. Stiller CR, Sinclair ... Incidence and clinical significance of de novo donor specific antibodies after kidney transplantation. Clin Dev Immunol. 2013; ... Transplantation. 2000; 69(7):1370-4. Gebel HM, Bray RA, Nickerson P. Pre-transplant assessment of donor-reactive, HLA-specific ...
Song Jeremy J (2013). "Regeneration and experimental orthotopic transplantation of a bioengineered kidney". Nature Medicine. 19 ... Regenerative capacity of the kidney has been recently explored. The basic functional and structural unit of the kidney is ... The regenerative capacity of the mammalian kidney is limited compared to that of lower vertebrates. In the mammalian kidney, ... Like other organs, the kidney is also known to regenerate completely in lower vertebrates such as fish. Some of the known fish ...
The drug is used primarily in liver and kidney transplantations, although in some clinics it is used in heart, lung, and heart/ ... Pancreas-Kidney Transplantation: Drugs, a brief history of immunosuppressive drugs. Accessed on 21 August 2005. WSAVA 2001 - ... They are used in the prophylaxis of the acute organ rejection after bilateral kidney transplantation, both being similarly ... Non-melanoma skin cancer (NMSC) after kidney transplantation is common and can result in significant morbidity and mortality. ...
"Regeneration and experimental orthotopic transplantation of a bioengineered kidney" (PDF). Nature Medicine. 19 (5): 646-651. ... On April 14, 2013, the first kidney grown in a rat in vitro in the U.S. was published. On May 1, 2013, China signed a new ...
Kidney transplantation outcomes for children with congenital nephrotic syndrome are similar to those of other patient groups. ... urinary loss of vitamin D binding protein Acute kidney injury Chronic kidney disease and ultimately end-stage kidney disease ... Immunizations are recommended after kidney removal but prior to transplantation. Patients may also take iron supplements, ... Nephrotic syndrome typically does not reoccur following kidney transplantation, however recurrences have been seen in children ...
Kidney transplantation and Corneal transplantation are conducted in the Hospital.. ... The main purpose of this association is to receive the donor's bodies for corneal transplantation to the blind, research ...
A number of research deal with the development of a strategy utilizing this phenomenon in transplantation immunology. The goal ... Tilney, N. L.; Guttmann, R. D. (1997-10-15). "Effects of initial ischemia/reperfusion injury on the transplanted kidney". ... In 1989 was successfully induced classical transplantation tolerance to skin grafts in adult mice using antibodies blocking T ... Gershon, R. K. (1975). "A disquisition on suppressor T cells". Transplantation Reviews. 26: 170-185. doi:10.1111/j.1600-065x. ...
On 25 October 2008, a kidney transplantation was carried out successfully. Gușet died on 12 June 2017 in Cluj Napoca, Romania ... Due to health problems (chronic kidney disease) he was forced to retire from competitions in 2008. ...
American Journal of Transplantation. September 2015, 15 (9): 2431-42. PMID 25943855. doi:10.1111/ajt.13288.. ... Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients. ... The role of peripheral T-cell deletion in transplantation tolerance. Philosophical Transactions of the Royal Society of London ... IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cellular Physiology and Biochemistry. 2016, 38 ...
It is also used as induction therapy in highly sensitized patients going for kidney transplantation. The use of rituximab has ... Rituximab is being used off-label in the management of kidney transplant recipients. This drug may have some utility in ...
... (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation. American Society for Blood and Marrow Transplantation. 2 (1): 3-14. PMID 9078349. ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ... a b Memorial Sloan-Kettering Cancer Center , Blood & Marrow Stem Cell Transplantation , The Graft-versus-Tumor Effect Archived ...
For example, gastroenterologists and nephrologists specialize respectively in diseases of the gut and the kidneys.[23] ... The anesthesiologist's role during surgery is to prevent derangement in the vital organs' (i.e. brain, heart, kidneys) ...
Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ... Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... dialysis or kidney transplantation) and plasma exchange. Kidney problems can have significant impact on quality and length of ...
Liver transplantation may be a valid option if no improvement occurs.[33] ... while the lung and kidneys may also be capable of storage.[20] ...
... "permanent kidney damage, sometimes resulting in kidney failure that has required kidney dialysis or kidney transplantation. In ...
The recipient of a hand transplant needs to take immunosuppressive drugs similar to other transplants such as kidneys or livers ... 2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The "donor" hand usually comes ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team,[14] performed a hand ...
Narita M, Muder RR, Cacciarelli TV, Singh N (August 2008). "Protothecosis after liver transplantation". Liver Transpl. 14 (8), ... Bondarenko VI, Zadorozhnaia VI (March 1992). "[The role of enteroviruses in the etiology of diseases of the pancreas, kidneys ...
April 2000). "Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to- ... and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by ... "Liver transplantation for homozygous familial hypercholesterolaemia". Arch. Dis. Child. 73 (5): 456-8. doi:10.1136/adc.73.5. ... "Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous ...
Vanderbilt also offers an organ transplantation center. Vanderbilt's first kidney transplant was in 1962; since then there have ... been more than 3,000 kidneys transplanted at Vanderbilt. VUMC has also had more than 2000 liver transplants and 600 heart and ...
... or absent kidneys with resultant chronic kidney disease or kidney failure. Ear anomalies include extra openings in front of the ... "Nephrology Dialysis Transplantation. 17 (6): 1014-1018. doi:10.1093/ndt/17.6.1014. ISSN 0931-0509. PMID 12032190.. ... "Kidney International. 65 (2): 369-385. doi:10.1111/j.1523-1755.2004.00390.x. ISSN 0085-2538. PMID 14717907.. ... Branchio-oto-renal syndrome (BOR) , is an autosomal dominant genetic disorder involving the kidneys, ears, and neck. It often ...
Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ...
University Hospital ranked among top 50 hospitals in the U.S. in three specialties: Respiratory Disorders, Kidney Disease and ... Other noted programs include: cellular and structural biology, urology, nephrology, transplantation biology, aging and ...
TransplantationEdit. Main article: Kidney transplantation. Millions of people across the world suffer from kidney disease. Of ... the complete loss of kidney function. Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney ... Kidney disease usually causes a loss of kidney function to some degree and can result in kidney failure, ... Generally, the progression of kidney disease is from mild to serious. Some kidney diseases can cause kidney failure. ...
For the development of liver transplantation, which has restored normal life to thousands of patients with end-stage liver ... Development of renal hemodialysis, which changed kidney failure from a fatal to a treatable disease, prolonging the useful ...
... a non-profit to raise awareness about organ donation and transplantation upon finding out his cousin was in need of a kidney ... with kidney transplant recipient Dillon Gonzalez and his family in attendance. The foundation was funded in part by admission ...
Retrograde ureteral, an intervention used to remove kidney stones. References[edit]. *^ El-Ghar MA, Osman Y, Elbaz E, Refiae H ...
OMIM entries on UMOD-Related Kidney Disease Includes: Familial Juvenile Hyperuricemic Nephropathy, Medullary Cystic Kidney ... Stamp L, Searle M, O'Donnell J, Chapman P (2005). "Gout in solid organ transplantation: a challenging clinical problem". Drugs ... A ketogenic diet impairs the ability of the kidney to excrete uric acid, due to competition for transport between uric acid and ... The gene SLC2A9 encodes a protein that helps to transport uric acid in the kidney. Several single nucleotide polymorphisms of ...
Hemolyzed hemoglobin is bound to a protein in plasma called haptoglobin, which is not excreted by the kidney.[48] ... The blood type needs to be determined to prepare for a blood transfusion or an organ transplantation. ... synthesised by the kidney. Just before and after leaving the bone marrow, the developing cells are known as reticulocytes; ...
A fully functional thymus derived from reprogrammed mouse embryonic fibroblasts has been grown in the kidney capsule of mice. ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ...
Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ... Laboratory tests that might show abnormalities include blood count, kidney function, electrolyte, and liver enzyme tests.[17] ... Chemotherapies or stem cell transplantations may require a platelet transfusion to prevent bleeding.[58][59] Moreover, patients ... Stem cell transplantation may be used if the disease recurs following standard treatment.[2] Additional treatments such as ...
Kidney failure (either secondary to severe hepatitis[64][69] or caused by direct toxic kidney damage[60]) and coagulopathy may ... Ganzert M, Felgenhauer N, Zilker T (2005). "Indication of liver transplantation following amatoxin intoxication". Journal of ... The principal toxic constituent is α-amanitin, which damages the liver and kidneys, causing hepatic and renal failure that can ... April 2006). "Letter to the editor: Liver transplantation represents the optimal treatment for fulminant hepatic failure from ...
Kidney disease, Sarcopenia, surgery recovery, Pregnancy, Osteoporosis, Ulcer and so on.[12] ...
Koppel MH, Coburn JW, Mims MM, Goldstein H, Boyle JD, Rubini ME (1969). "Transplantation of cadaveric kidneys from patients ... Individuals with pre-renal kidney failure do not have damage to the kidneys, but as in individuals with HRS, have kidney ... of the kidney circulation and worsening kidney vasoconstriction, leading to kidney failure.[12] ... The kidney failure in hepatorenal syndrome is believed to arise from abnormalities in blood vessel tone in the kidneys.[2] The ...
Kidney transplants: It can be found in up to 20% patients, can be related to azathioprine or cyclosporine use, and may be ... "Laparoscopic study of peliosis hepatis and nodular transformation of the liver before and after renal transplantation: natural ... It also occasionally affects spleen, lymph nodes, lungs, kidneys, adrenal glands, bone marrow, and other parts of ... Chronic conditions: End stage kidney failure, kwashiorkor, tuberculosis, and other chronic infections ...
"Biology of Blood and Marrow Transplantation. 15 (12): 1628-33. PMC 2861656 . PMID 19896087. doi:10.1016/j.bbmt.2009.07.004.. ... Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct effects of drug clearance by the ... This causes kidney damage and the high levels of potassium can cause cardiac arrhythmia. Although prophylaxis is available and ... Different drugs will affect different parts of the kidney and the toxicity may be asymptomatic (only seen on blood or urine ...
Hemophilia A has been corrected by liver transplantation. Transplanting hepatocytes was ineffective, but liver endothelial ... C and the nucleotide sequence and expression of the human kidney cDNA". Dna. 4 (5): 333-49. doi:10.1089/dna.1985.4.333. PMID ...
Kidney → 콩팥 (C). *Urinary bladder → 방광 (E). 식물 형태학 및 해부학, 23[편집]. *Plant cell *Cell wall → 세포벽 (D) ... Organ transplantation → 장기 이식 (B). *Palliative care *Radiation therapy → 방사선종양학과 (E). *Surgery → 외과 (E) ...
Hematopoietic cell transplantation[edit]. On January 13, 2011, City of Hope performed its 10,000th hematopoietic stem cell ... National Library of Medicine/National Institute of Diabetes and Digestive and Kidney Diseases grant to City of Hope's ... Association of Community Cancer Centers, National Bone Marrow Transplantation Research Network, National Gene Vector Laboratory ... transplantation, which includes transplants of bone marrow, peripheral blood stem cells collected by apheresis, and umbilical ...
... access to kidney transplantation.. Kidney transplantation is the preferred treatment for kidney failure. Among kidney failure ... Kidney transplantation is the preferred treatment for kidney failure patients, but blacks are less likely to receive kidney ... Requiring a formal patient education class may help reduce disparities in kidney failure patients access to kidney ... The researchers retrospectively examined information from 1,126 kidney failure patients who were referred for kidney transplant ...
Kidney Transplantation. CPKT is defined as Combined Pancreas-/Kidney Transplantation somewhat frequently. ... Kidney Transplantation abbreviated? CPKT stands for Combined Pancreas-/ ... 2021 *Chicago style: Acronym Finder. S.v ... a href=,CPKT,/a,. ...
Meaning of kidney transplantation. What does kidney transplantation mean? Information and translations of kidney ... transplantation in the most comprehensive dictionary definitions resource on the web. ... Definition of kidney transplantation in the dictionary. ... Kidney transplantation. Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with ...
Whats the current actual cost of kidney transplantation?. -The National Central Hospital No.1 conducts kidney transplantation ... This applies to every organ transplantation patients, not just kidney transplantation patients. Organ transplantation patients ... D.Nyamsuren: Kidney transplantation fee must be raised. By B.DULGUUN. The first kidney transplant procedure in 1996 by ... These people need kidney transplantation. There are also a number of people unable to get artificial kidney devices. They also ...
Swedish is a longstanding leader in organ transplantation in the Pacific Northwest, particularly kidney transplantation. Now ... Swedish Organ Transplant Program Celebrates 40 Years of Kidney Transplantation Receives Medicare Certification for Liver ... Swedish Organ Transplant Program Celebrates 40 Years of Kidney Transplantation, Receives Medicare Certification for Liver ... organ transplantation and clinical research. In 2012, Swedish provided more than $130 million in community benefit in Western ...
Kidney transplantation is the treatment of choice for selected patients with ESRD. A successful kidney transplantation improves ... Reverse Left Ventricular Remodeling After Kidney Transplantation Message Subject (Your Name) has forwarded a page to you from ... 7) report the results of an observational study that describes the effects of successful kidney transplantation on cardiac ... The observed improvement in LVEF after kidney transplantation is consistent with previous studies with serial measurements of ...
Read more about the process and details of a kidney transplantation and how they may affect your body. ... Diet and Transplantation (National Kidney Foundation) Also in Spanish * From Illness to Wellness: Life After Transplantation ( ... Kidney Transplant (National Kidney Foundation) Also in Spanish * Kidney Transplant (Mayo Foundation for Medical Education and ... Solitary Kidney (National Institute of Diabetes and Digestive and Kidney Diseases) * Travel Tips: A Guide for Kidney Patients ( ...
... few fields of medicine have undergone the rapid advances that have been seen with kidney transplantation. From the development ... Is routine ureteric stenting needed in kidney transplantation? A randomized trial. Transplantation. 2000;70:597-601.CrossRef ... Kidney Transplantation. In: Humar A., Sturdevant M. (eds) Atlas of Organ Transplantation. Springer, London. * First Online 31 ... Surgical complications after kidney transplantation. Semin Dial. 2005;18:505-10.CrossRefPubMedGoogle Scholar ...
Title: Handbook of Kidney Transplantation, Author: champmails32538, Name: Handbook of Kidney Transplantation, Length: 2 pages, ... E-book download Handbook of Kidney Transplantation {fulll,online,unlimite) KWH. E-book download Handbook of Kidney ...
... kidney, liver, pancreas and stem cell transplantation. The journal welcomes submissions focusing on the histocompatibility as ... Journal of Transplantation is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... well as related side effects and complications of those transplantations. ... Kidney transplantation is the treatment of choice for most patients with stage five chronic kidney disease (CKD). The risk of ...
... kidney, liver, pancreas and stem cell transplantation. The journal welcomes submissions focusing on the histocompatibility as ... Journal of Transplantation is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... well as related side effects and complications of those transplantations. ... Bortezomib in Kidney Transplantation. Rajeev Raghavan,1,2 Abdallah Jeroudi,1 Katafan Achkar,3,4 A. Osama Gaber,5 Samir J. Patel ...
Purchase Kidney Transplantation, Bioengineering, and Regeneration - 1st Edition. Print Book & E-Book. ISBN 9780128017340, ... Kidney Transplantation, Bioengineering, and Regeneration 1st Edition. Kidney Transplantation in the Regenerative Medicine Era. ... PART I: Kidney Transplantation. Section I: Epidemiology of kidney disease and transplantation. Section II: Donor selection and ... Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates ...
Heart transplantation (HTx) remains the gold-standard treatment for those with advaced HF. Renal failure (RF) is... ... Simultaneous heart-kidney transplantation is superior to sequential heart-kidney transplantation in renal failure heart ... Renal graft outcome in combined heart-kidney transplantation compared to kidney transplantation alone: a single-center, matched ... Combined heart-kidney transplantation: a review of recipient selection and patient outcomes. Adv Chronic Kidney Dis. 2009;16: ...
... more than 82,000 patients are waiting for kidney transplants in the United States. ... Renal transplantation has become the treatment of choice for most patients with end-stage renal disease (ESRD). At present, ... living-donor kidney transplantation followed by pancreas-after-kidney transplantation is a reasonable option. Combined kidney- ... encoded search term (Kidney Transplantation) and Kidney Transplantation What to Read Next on Medscape. Related Conditions and ...
Meanwhile Tarun himself is suffering from kidney failure. As... ... kidney transplantation johnwilliams321 please help me with my ... Varuns last wish before he lost consciousness was that his kidney be donated to his brother. The boys are fraternal twins. The ... Would you take Varun off life-support before he is officially declared dead? What are Taruns chances with Varuns kidney? What ... Meanwhile Tarun himself is suffering from kidney failure. As his parent you have to make a crucial decision. ...
Clinical operational tolerance after kidney transplantation.. Roussey-Kesler G1, Giral M, Moreau A, Subra JF, Legendre C, Noël ... In this article, we report on the medical history of 10 kidney recipients who display an immunosuppressive drug-free " ... state in recipients under immunosuppression with long-term stable graft function are major challenges in transplantation. ... which mimics the procedure of intentional immunosuppression weaning following liver transplantation. Secondly, donor age was ...
Kidney Transplantation: Analysis of 200 Cases Br Med J 1974; 4 :553 ... Kidney Transplantation: Analysis of 200 Cases. Br Med J 1974; 4 doi: (Published 07 ... On the other hand, the survival of patients undergoing renal transplantation steadily improved, the most recent survival rates ... We conclude on both social and economic grounds that renal transplantation is fully justified as a therapeutic procedure. ...
Description: For individuals who want to understand the kidney transplant process-from pre-transplant evaluation, to wait list ...
Successful Kidney Transplantation in a Patient with Unipapillary Kidney Kosoku A. , Uchida J. , Shimada H. , Kabei K. , Nishide ... Donor nephrectomy for living kidney transplantation [in Japanese] 新保 正貴 , 遠藤 文康 , 木村 貴明 , 大山 雄大 , 小松 健司 , 長浜 正彦 , 南木 浩二 , 佐久間 康 ... Simultaneous pancreas-kidney transplantation: Initial experience of a center in Japan Ono Shinichiro , Adachi Tomohiko , Hidaka ... p,The patient was a man in his sixties who received kidney transplantation from a deceased donor. … Five months after
Kidney transplantation : principles and practice. [Peter J Morris; Stuart J Knechtle;] -- Updated to reflect todays practice ... guidelines, the new edition of this comprehensive text remains the definitive resource on all aspects of renal transplantation ... Pancreas and kidney transplantation for diabetic nephropathy --. Kidney transplantation in children --. Renal transplantation ... transplantation> # Kidney Transplantation a schema:Intangible ;. schema:name "Kidney Transplantation"@en ;. . ...
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... kidney failure, organ donation, pre-operative evaluation, post-operative care, complications, discharge, and follow-up. Must ... Live Donor Kidney Transplantation - Improving the Short and Long Term Results. * First ABO-Incompatible Kidney Transplantation ... Paired Donor Exchange Kidney Transplantation. Paired donor exchange kidney transplantation is a process in which unrelated ... Quiz on Kidney. How healthy are your kidneys? Is it possible to lead healthy lives with just a single kidney? Learn more by ...
Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease ... Kidney transplantation is a life-extending procedure.[54] The typical patient will live 10 to 15 years longer with a kidney ... "Kidney transplant". Retrieved 2009-07-20.. *^ a b c d Renal Transplants , Renal Transplantation Complications ... Kidney transplantation is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantation ...
[email protected] Abstract. Live donor kidney transplantation has become a widely sought treatment by patients with ... Nevertheless, live donor kidney transplantation may not be the realistic final solution to an international public health ... Living donor kidney transplantation in a global environment.. Delmonico FL1, Dew MA. ... this review considers live kidney transplantation from the broad scope of current international practice. Unrelated live donor ...
Provides optimal management of medical and surgical issues in kidney transplantation recipients Authoritative and up-to-date ... Kidney Transplantation offers the latest evidence-based information on the full range of dilemmas in the medical management of ... Kidney Transplantation. Book Subtitle. Practical Guide to Management. Editors. * Matthew R. Weir ... Kidney Transplantation. Practical Guide to Management. Editors: Weir, Matthew R., Lerma, Edgar V. (Eds.) ...
... this book analyzes the implications that transplantation and immuno ... Discussing the many complications that may occur after kidney transplantation, this source is a must for anyone caring for ... With color illustrations throughout, this book analyzes the implications that transplantation and immunosuppression can hold ...
... access to kidney transplantation should not be influenced by residence location. We determined the likelihood of kidney ... Residence location and likelihood of kidney transplantation. Marcello Tonelli, Scott Klarenbach, Braden Manns, Bruce Culleton, ... Residence location and likelihood of kidney transplantation. Marcello Tonelli, Scott Klarenbach, Braden Manns, Bruce Culleton, ... We studied kidney transplantation from deceased donors as an example of a scarce medical resource that is rationed in Canadas ...
Kidney TransplantationStudy of a JAK3 Inhibitor for the Prevention of Acute Rejection in Kidney Transplant Patients NCT00483756 ... Kidney TransplantationA 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients NCT00106639 ... Kidney TransplantationCollection of Follow-up Data From CP-690,550-treated Kidney Transplant Recipients NCT01375127 ... Kidney TransplantationStudy Comparing Standard Dose and Reduced Dose Tacrolimus With Sirolimus in Renal Transplant Patients ...
We provide comprehensive and cutting-edge treatment for people who need a kidney transplant. ... UC San Diego Healths Kidney Transplant Program is San Diego Countys largest program, caring for transplant recipients and ... Living Kidney Donation. As part of the National Kidney Registrys Paired Exchange Program, we have the unique ability to allow ... 50: In 2018, we celebrated 50 years as San Diego regions first kidney transplantation program. ...
Learn about receiving a transplant or giving your organ with this National Kidney Foundation provided information. ... Kidney Walk. The Kidney Walk is the nations largest walk to fight kidney disease. Held in nearly 100 communities, the event ... Are you at Risk for Metabolic Syndrome after Kidney Transplantation?. *What Vaccinations Do You Need? A guide for adults with ... Provides the latest information about legislation and policy relating to chronic kidney disease, transplantation and donation. ...
Kidney transplant patients had a higher risk of being hospitalized within the first several months to a year, but they had a ... Kidney transplant patients had a reduced risk of treatment failure or premature death compared with patients on long and ... Kidney transplantation found superior to intensive home hemodialysis Transplantation linked with better treatment success and ... Washington, DC (May 22, 2014) -- Compared with long and frequent home hemodialysis, kidney transplantation may allow kidney ...
Bioengineered kidney makes urine after transplantation. 14 Apr 2013 , 13:00 EDT. , Posted by Kevin Jiang , Category: Featured, ... scientists reporting in Nature Medicine have created lab-grown kidneys in rats that produce urine after transplantation. ... By and large this appears to be a waste of research money! Organs like kidney are very complex and it is hard to believe that ... If the work can be replicated in humans, patients suffering from end-stage kidney disease could one day have "an organ thats ...
Kidney failure occurs for a variety of reasons, the most common being diabetes, high blood pressure, drug overdose, and ... Kidney DiseaseKidneyKidney HealthStones in Urinary TractRenal Tubular AcidosisTransplantationOrgan Donation and Transplantation ... Inequities in Access to Kidney Transplantation Exist Even With Universal Healthcare: Study Kidney Transplants: Volume of ... Kidney donation for transplantation varies with each country depending on the demand, social sensitivity, and legislation. ...
Obstacles to Organ Donations: The Dire State of Kidney Transplantation. Share*Tweet ... The only cure is a kidney transplant.. However, a severe kidney shortage exists right now: while about 17,000 transplants were ... Kidney disease kills more than 50,000 people each year-more than auto accidents, drug overdoses, or suicides. ... Various methods to increase the supply of available kidneys have proven to be either unworkable or insufficient to ...
  • Pre-transplant sera from 116 kidney transplant recipients with a negative CDC crossmatch were assessed for donor-specific HLA antibodies by using Luminex single antigen beads. (
  • Some groups consider very elderly patients as preferred to receive kidneys from cadaveric donors with criteria such as age, obtained in asystole, among others, or be double transplant recipients with this kind of donors. (
  • The 2012 Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR) annual report showed that the conditional graft half-life (defined as the time to when half of the grafts surviving at least one year are still functioning) was 12.5 years for deceased donor transplants and 15.3 years for living donor transplants in 2009-2010. (
  • a recent analysis of more than 250,000 kidney transplant recipients demonstrated that death-censored graft half-life for all deceased donor transplants increased from 10.2 years in 1989 to 14.3 years in 2005, and remained approximately 16.5 years for living donor transplants during the same time period. (
  • Tacrolimus received FDA approval in 1994 for liver transplant recipients, and in 1997 for kidney transplants. (
  • Over 85% of kidney transplant recipients are discharged from their transplant admission on tacrolimus as part of their maintenance immunosuppressive regimen. (
  • 5 It has also been associated with an increased incidence of new onset diabetes and the development of metabolic syndrome, which are significant concerns because the main cause of death among kidney transplant recipients is cardiovascular disease. (
  • Introduction: The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. (
  • To determine the impact of pretransplant donor-specific HLA antibodies (DSA) detectable by Luminex, despite a negative CDC crossmatch, on the outcomes of kidney transplantation. (
  • The results were correlated with kidney graft outcomes. (
  • Without there being any exact rules, once the chronic nature of the process of kidney disease appears, and once the decreased renal function is established -usually when the glomerular filtration rate reaches values of about 30 ml / min-, it is necessary to present the different options renal replacement therapy (RRT) to which we must resort when kidney function values are close to being truly insufficient. (
  • INTERPRETATION: Compared with standard basiliximab-based treatment, alemtuzumab-based induction therapy followed by reduced CNI and mycophenolate exposure and steroid avoidance reduced the risk of biopsy-proven acute rejection in a broad range of patients receiving a kidney transplant. (
  • Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation. (
  • In addition to general medical and surgical care including robotic-assisted surgery, Swedish is known as a regional referral center, providing specialized treatment in areas such as cardiovascular care, cancer care, neuroscience, orthopedics, high-risk obstetrics, pediatric specialties, organ transplantation and clinical research. (
  • Clinical relevance of HLA donor-specific antibodies detected by single antigen assay in kidney transplantation. (
  • Discussion: We could not find the association of mTOR inhibitors use and risk of de novo cancer development or mortality in patients with kidney transplantation in Chinese patients. (
  • Long-Term Outcome of Kidney Transplantation in Children (D. Potter). (
  • abstract = "Background: Previous studies show that mTOR inhibitors decrease the risk of cancer development after kidney transplantation. (
  • Further research is needed to clarify the role of dnDSA screening in pediatric kidney transplantation. (
  • Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant," New England Journal of Medicine , vol. 341, no. 23, pp. 1725-1730, 1999. (
  • KDIGO clinical practice guideline for the care of kidney transplant recipients," American Journal of Transplantation , vol. 9, supplement 3, pp. (
  • Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients," Transplantation , vol. 70, no. 6, pp. 887-895, 2000. (
  • Wait list death and survival benefit of kidney transplantation among nonrenal transplant recipients. (
  • Outcomes in recipients of combined heart-kidney transplantation: multiorgan, same-donor transplant study of the International Society of Heart and Lung Transplantation/United Network for Organ Sharing Scientific Registry. (
  • Induction of allograft-specific tolerance and the detection of a "tolerance" state in recipients under immunosuppression with long-term stable graft function are major challenges in transplantation. (
  • In this article, we report on the medical history of 10 kidney recipients who display an immunosuppressive drug-free "operational tolerance" for 9.4 +/- 5.2 years. (
  • It examines evaluation, management, and procurement of living and deceased donor kidneys, the selection of suitable recipients, interpretation of graft dysfunction, and expected survival based upon a large database of information. (
  • With the increased prevalence of kidney transplantation, transplant recipients are being treated in a variety of clinical settings - often beyond the transplant center. (
  • Kidney Transplantation offers the latest evidence-based information on the full range of dilemmas in the medical management of kidney transplant recipients before, during and after transplantation. (
  • The purpose is to help healthcare providers in all settings understand health issues unique to kidney transplant recipients and how to best provide quality care for this patient population. (
  • The audience is all providers of healthcare to kidney transplant recipients, including those in non-transplant settings. (
  • We are dedicated to providing comprehensive care for transplant recipients and living donors before, after and during transplantation. (
  • Closely monitor such recipients following transplantation and provide appropriate antiviral therapy (agents that prevent viral proliferation or antibodies directed against a specific virus). (
  • Cohort studies comparing adult chronic dialysis patients with kidney transplantation recipients for clinical outcomes were selected. (
  • Despite increases in the age and comorbidity of contemporary transplant recipients, the relative benefits of transplantation seem to be increasing over time. (
  • Aetiologies of mortality in our kidney transplant recipients were determined. (
  • The aim of this review is to evaluate retrospectively the incidence and aetiologies of mortality in our kidney transplant recipients. (
  • Although a validated scale exists to assess knowledge of kidney transplantation among waitlisted candidates and recipients, 6 this tool has yet to be validated among ESRD patients not on the waitlist, a population likely to have lower transplant knowledge. (
  • Methods - The researchers performed a retrospective cohort study using healthcare administrative data of all adult-incident kidney-only transplantation recipients in Ontario, Canada from 1994 to 2009. (
  • Results - Among 4,958 kidney transplant recipients, the three-year cumulative incidence of hospitalization with nontraumatic major hemorrhage was 3.5% (95% confidence interval [CI] 3.0-4.1%, 12.7 events per 1,000 patient-years) compared to 0.4% (95% CI 0.4-0.5%) in the general population (RR = 8.2, 95% CI 6.9-9.7). (
  • Conclusion - Kidney transplantation recipients have a higher risk of hospitalization with hemorrhage compared to the general population, with about 1 in 30 recipients experiencing a major hemorrhage in the three years following transplant. (
  • Between March 2010 and April 2012, the researchers biopsied 651 kidneys (taken from 369 donors through four organ procurement organizations) that were subsequently transplanted into recipients. (
  • In another study, Bertram Kasiske, MD (Scientific Registry of Transplant Recipients and Hennepin County Medical Center) and his colleagues compared the results of biopsies from kidneys that were discarded with the results of biopsies from comparable kidneys that were successfully transplanted. (
  • 2. Heldal K, Hartmann A, Leivestad T, Svendsen MV, Foss A, Lien B, Midtvedt K. Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity. (
  • Thanks to new advances in anti-viral and immunosuppression drugs, hepatitis C-negative recipients can receive a kidney from a hepatitis C-positive donor. (
  • Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients is an easy to read, up to date, clinical resource written by experts in the field of kidney transplantation. (
  • The book explains how donors and recipients are selected for transplantation, how the surgical procedure is performed, and how the experts recognize and treat rejection. (
  • The study is a double-blind, randomized, controlled, dose-escalation and safety study of the investigational product, autologous MSCs, to be assessed for inducing immune suppression in living donor kidney transplant recipients as compared to saline, the placebo infusion. (
  • The 1-year mortality of renal transplant patients is 6% for deceased donor recipients and 3% for living donor kidney recipients compared to 25% for patients treated with dialysis, reflecting the fact that transplant recipients represent a relatively healthier subset of patients with ESRD compared to dialysis patients. (
  • Over the years, the Program's firm commitment to transplantation has been evident through its extensive involvement with clinical research trials for it young kidney recipients who face different challenges than adult kidney recipients in regards to drug therapies and physical and cognitive growth and development. (
  • After analyzing information on 88,209 donors (176,418 kidneys), the researchers found that although the discarded kidneys in these pairs frequently had traits that are typically considered unappealing, the partner kidneys that shared many, if not all of the same traits performed well after being used for transplantation despite being used in older recipients with more medical problems. (
  • In a study of kidney transplant recipients, PPI users had an almost 2-fold increased risk of mortality compared with nonusers. (
  • In a study of white related living kidney donors and recipients, investigators found that older donors are at increased risk of end-stage renal disease (ESRD) if the recipients are older at the time of ESRD onset. (
  • In a study, recipients of A2 incompatible kidneys from living donors had a 60% higher risk for death-censored graft failure than recipients of blood type compatible kidneys. (
  • Kidney transplant recipients with pre-existing pulmonary hypertension had a 1.5-fold increased risk for death compared with recipients without the condition, a study found. (
  • Researchers are also experimenting with splitting one kidney for two recipients. (
  • Researchers are also experimenting with splitting 1 kidney for 2 recipients. (
  • Our commitment to excellence and focus on the patient experience has led to high satisfaction for recipients and living kidney donors alike. (
  • U.S. Organ Procurement and Transplantation Network the Scientific , Registry of Transplant Recipients. (
  • This policy permits A2-to-O and A2B-to-B transplantation in order to shorten the waiting time for group O and group B recipients, respectively ( 11 - 13 ). (
  • Cardiovascular disease is both a major threat to the life expectancy of kidney transplant recipients and an important determinant of late allograft loss. (
  • One year posttransplant BMI and BMI increment are more strongly related to death and graft failure than pretransplant BMI among kidney transplant recipients. (
  • As a result, Penn Medicine physicians launched the THINKER study: a clinical trial that involves transplanting kidneys from deceased donors with hepatitis C to recipients without HCV, then curing the recipients of the disease. (
  • Ten recipients were given kidneys from donors with HCV, and all tested positive for HCV after the surgery. (
  • Washington, DC (September 11, 2014) -- Concerns about pursuing kidney transplantation are highly prevalent among kidney failure patients, particularly older adults and women, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology ( CJASN ). (
  • Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients. (
  • There are many potential reasons why a candidate might delay completing the testing required for transplant evaluation, according to Talamantes and senior author Edmund Huang, associate professor of nephrology with UCLA Health and acting associate professor in nephrology and the Kidney Transplant Program at Cedars-Sinai. (
  • Biopsies of donated kidneys provide little information for determining the suitability of organs for transplantation, according to two studies appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). (
  • Since 1996, The Pediatric Nephrology and Transplantation Program has been improving the quality of life for New Jersey's youngest patients with renal disease, renal dysfunction and hypertension. (
  • When a child's kidneys are not working, the whole body's physiology changes," explains Isabel Roberti, M.D., Director of Pediatric Nephrology and Transplantation. (
  • The findings, which come from a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), provide further evidence that many of the donated kidneys that are discarded are in fact suitable for use. (
  • The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS). (
  • Dr. Robert S. Gillespie Medical Director, Nephrology and Kidney Transplantation, and Dr. Blake W. Palmer, Medical Director, Urology Cook Children's Medical Center, join together in a discussion about the unique challenges of kidney transplant in children and how Cook Children's nephrology and urology programs partner to achieve the best possible results. (
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. (
  • For patients on the waiting list for a kidney transplant, severe and morbid obesity are associated with a lower chance of receiving an organ, reports a study in the February Journal of the American Society of Nephrology . (
  • With passion for education and Transplantation, he accepted the fellowship in Nehrology and Hypertension at Georgetown University in Washington, DC and continued his education at University of California San Francisco (UCSF) with a Transplant Nephrology fellowship. (
  • He was appointed at the Medical director of Pancreas Transplantation at Westchester Medical Center, New York Medical college before moving to Loma Linda University in California to serve as an Assistant Professor of Medicine in Nephrology / Transplant division. (
  • He is an active member of American Society of Nephrology and American society of Transplantation. (
  • Multiple arteries in live donor renal transplantation: surgical aspects and outcomes. (
  • kidney transplantation (KT) after isolated HTx improves outcomes in these scenarios. (
  • The results support the need to encourage transplantation for potential candidates who are receiving home hemodialysis, but they also indicate that long and frequent home hemodialysis provides good outcomes for patients. (
  • The gap in clinical outcomes between all forms of kidney transplantation and the putative best forms of dialysis is large. (
  • Our patients may be invited to take part in a study that contributes to the understanding of transplantation immunobiology, clinical outcomes and how to better facilitate successful and safe transplantation in both the short and long term. (
  • Chirag Parikh, MD, PhD and Isaac Hall, MD, MS (Yale University and Veterans Affairs Medical Center) led a team that looked for associations between biopsy-reported kidney injury at the time of organ procurement with subsequent kidney transplant outcomes. (
  • They also compared outcomes for HCV-infected kidneys to similar quality HCV-uninfected kidneys. (
  • The majority of discarded kidneys could have potentially been transplanted with good outcomes. (
  • ABO-incompatible transplantation should increase "live donor" kidney transplantation, reduce waiting times, and improve patient outcomes. (
  • Kidney transplantation is the treatment of choice for most patients with stage five chronic kidney disease (CKD). (
  • US Renal Data System, "USRDS 2009 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States," Chapter 7, page 292, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md, USA, 2009. (
  • Indications for kidney transplantation include chronic kidney disease (CKD) and renal tumors. (
  • Provides the latest information about legislation and policy relating to chronic kidney disease, transplantation and donation. (
  • Individual studies indicate that kidney transplantation is associated with lower mortality and improved quality of life compared with chronic dialysis treatment. (
  • Abstract Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. (
  • With advances in kidney transplant methods and improvement in transplant success, a kidney transplant is now widely considered to be the best way of treating chronic kidney disease for many people. (
  • His interests are in Hypertension and Oxidative Stress in patients with chronic kidney disease and transplantation. (
  • The level of oxidative stress markers is known to increase as Chronic Kidney Disease (CKD) progresses and correlates significantly with level of renal function. (
  • Kidney Transplant COM/150 June 6, 2010 Axia College of University of Phoenix Kidney disease has become more prevalent over the years, one in nine Americans has chronic kidney disease, resulting in the need for a kidney transplant. (
  • Kidney failure can be broken down into three groups: acute, chronic, end-stage. (
  • It is done to replace kidneys with chronic kidney failure. (
  • Quality of life after kidney and pancreas transplantation: a review. (
  • The Kidney and Pancreas Transplantation program, operated in partnership with the Rogosin Institute, offers the latest surgical interventions and medical management protocols to treat adults and children who receive a donor kidney or pancreas. (
  • The pancreas transplantation program offers a therapeutic option for patients with type 1 diabetes who have developed significant complications, including nerve problems, retinal disease, or the inability to tell when their blood glucose is low. (
  • From the development of the surgical techniques necessary for transplantation at the beginning of the century to the dawn of modern transplantation with the introduction of immunosuppressants in the late 1950s, and to its current status as the treatment of choice for end-stage renal disease (ESRD), renal transplantation has enjoyed remarkable progress. (
  • Kidney transplantation is the treatment of choice for a minority of patients with end-stage renal disease (ESRD). (
  • Background: Simultaneous pancreas- kidney transplantation (SPK) is an established therapy for diabetes mellitus (DM) patients with associated end stage renal disease. (
  • The rising incidence of lifestyle related diseases like diabetes and hypertension has risen and has resulted in alarming rise of kidney disease in the world. (
  • Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease . (
  • [4] ( It was not until June 17, 1950, when a successful transplant was performed on Ruth Tucker, a 44-year-old woman with polycystic kidney disease , by Dr. Richard Lawler [5] at Little Company of Mary Hospital in Evergreen Park, Illinois. (
  • Thanks to new medications for hepatitis C, we can transplant some kidneys from patients with hepatitis C into patients without hepatitis C. We can then treat the kidney recipient for the disease after the transplant. (
  • Because kidney disease often has no symptoms, it can go unnoticed until it is very advanced. (
  • The Kidney Walk is the nation's largest walk to fight kidney disease. (
  • Get help navigating the challenges of kidney disease, organ donation and transplantation. (
  • If the work can be replicated in humans, patients suffering from end-stage kidney disease could one day have "an organ that's grown on demand-a tailored organ that can be transplanted and replaces the failing organ," says study author Harald Ott , a bioengineer at the Massachusetts General Hospital in Boston. (
  • Kidney disease kills more than 50,000 people each year-more than auto accidents, drug overdoses, or suicides. (
  • Age, sex, cause of end-stage renal disease (glomerulonephritis, diabetes, or other causes), pretransplant cardiovascular disease, vascular calcifications, time from first treatment for end-stage renal disease to kidney transplantation and acute tubular necrosis were recorded. (
  • Individuals with end-stage renal disease can get on a kidney transplant waiting list, but if they are "inactive" they are not eligible to receive a deceased donor kidney. (
  • Kidney transplantation is the preferred treatment modality for the majority of patients with end-stage renal disease (ESRD). (
  • Ultimately, this would reduce bias when interpreting results, allow researchers to compare results across study sites and kidney disease populations, and improve researchers' ability to identify which interventions have the greatest effect on improving patient transplant knowledge and in turn, access to kidney transplantation. (
  • Kidney transplantation is a lifesaving procedure for people with end-stage kidney disease. (
  • Kidney transplantation is a good treatment option for people with kidney disease. (
  • John & Meg Brogan's story: Two generations survive hereditary life-threatening kidney disease. (
  • USRDS 2004 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. Available at: (
  • Kidney transplantation halts cardiovascular disease progression in patients with end-stage renal disease. (
  • Recurrent and de novo glomerular disease after renal transplantation: a report from Renal Allograft Disease Registry (RADR). (
  • The influence of native nephrectomy on the incidence of recurrent disease following renal transplantation for primary glomerulonephritis. (
  • The most common indications for kidney transplantation are glomerulonephritis, cystic kidney disease, and type 1 diabetes. (
  • World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. (
  • Many patients with kidney disease are at high risk for severe COVID-19 illness, according to a CDC update. (
  • Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. (
  • In a kidney transplant, a patient with advanced renal (kidney) disease or kidney failure receives a healthy kidney from a living donor or from a recently deceased donor. (
  • For select patients, a kidney transplant can provide a very effective treatment of their renal disease-allowing them to function normally with few dietary restrictions, minor physical limitations, and continued maintenance on medications. (
  • During Fabry disease, progressive glycosphingolipid deposition in the kidney causes gradual deterioration of renal function with proteinuria, uremia and hypertension. (
  • Given the excellent graft and patient survival generally nowadays, kidney transplantation is the first choice to correct renal dysfunction and improve the overall prognosis of patients with renal failure because of Fabry disease. (
  • A kidney transplantation is the treatment of choice for patients of end stage renal disease. (
  • All patients at end stage kidney disease are theoretically eligible for kidney transplantation. (
  • Kidney disease means for some time your kidneys have not been working the way they should. (
  • Help AKF fight kidney disease. (
  • To investigate, Vishnu S. Potluri, MD, MPH, David S. Goldberg, MD, MSCE and Peter P. Reese, MD, MSCE (University of Pennsylvania) and their colleagues analyzed 2015-2019 national transplant registry data on the use of HCV-infected kidneys. (
  • There are comprehensive chapters on pediatric renal transplantation and on renal transplantation in the developing world. (
  • The pediatric kidney transplantation program is skilled at transplanting adult kidneys into children, and includes a living donor program that offers pre-emptive kidney transplantation before dialysis. (
  • The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. (
  • Clinical operational tolerance after kidney transplantation. (
  • In an editorial accompanying Dr. Kasiske's article, Sayeed Khan Malek, MD (Brigham and Women's Hospital) wrote, "When the biopsy findings are consistent with the clinical evaluation of the donor, they are useful in making the determination about transplanting the kidney. (
  • for the Clinical Practice Guidelines Committee of the American Society of Transplantation. (
  • Are you interested in clinical kidney, pancreas and islet transplantation? (
  • This course is also for anyone interested in the research and knowledge on clinical transplantation. (
  • We revealed one clinical case of unexplained and irreversible early graft dysfunction in a serologically matched pair, and it was verified by genotyping as A1-to-A2 transplantation. (
  • Studies show that kidney transplantation prolongs patient lifespan compared with dialysis. (
  • Traditionally, access to transplantation is rationed according to the anticipated benefit to individual patients compared with dialysis treatment. (
  • The risk of being admitted to the hospital and spending a longer time in the hospital was higher for some kidney transplant patients up to a year after transplantation, but lower in the long term compared with dialysis patients. (
  • The recipient, Richard Herrick, died eight years after the transplantation. (
  • Unrelated live donor transplantation can now be performed for incompatible donor recipient pairs via a simultaneous paired kidney donation. (
  • Transplantation of adult kidneys from either sex into a recipient of the opposite sex followed by ischemia at a remote time resulted in ischemia recovery that reflected the sex of the recipient, not the donor, revealing that the host sex determines recovery. (
  • Scales that are assessed for validity or reliability using transplant candidate or recipient populations may not be generalizable in measuring their intended constructs (ie, transplant knowledge) among ESRD patients who have yet to reach the kidney transplant waitlist. (
  • This guide to the care of the kidney transplant recipient aims to provide practical guidelines for management of the post-transplant recipient and is targeted to community nephrologists and general internists who care for the patient with a kidney transplant. (
  • The renal pedicle was ligated with 7-0 silk suture and the recipient left kidney was removed leaving place for the donor kidney. (
  • A positive cross match test means that the donor (whether live or deceased) is not compatible with the recipient, and therefore cannot donate a kidney. (
  • Please contact us at 716-898-5001 and we will provide you with all the information you need to become a successful kidney transplant recipient. (
  • Although a relatively simple operation, a kidney transplantation is not a simple task, neither for the recipient nor for the medical team. (
  • To avoid complications, the kidney transplant recipient must be evaluated by the medical team prior to the operation to ensure eligibility for this procedure. (
  • Pitfall in genetic screening in a pregnancy involving an allogeneic hematopoietic stem cell transplantation recipient. (
  • Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies," American Journal of Transplantation , vol. 10, no. 3, pp. 681-686, 2010. (
  • This is called a cross match and it is done to make sure there are no substances in the blood, called cytotoxic antibodies, that may cause the recipient's body to reject the transplanted kidney. (
  • 1 , 2 This practice is generally accepted because, unlike most other scarce medical resources, access to transplantation cannot be enhanced simply by increased resource allocation. (
  • In contrast, access to transplantation among suitable candidates should not be influenced by characteristics such as age, sex, race, socioeconomic status or residence location. (
  • 3 Compared with other industrialized nations, Canada is characterized by its large size and relatively few transplant centres, which suggests that access to transplantation may be influenced by geographic considerations. (
  • Reducing these concerns may help decrease disparities in access to transplantation. (
  • In an attempt to educate patients about the transplant process, the Emory Transplant Center's kidney program implemented a required educational session in 2007 for each patient who was referred for a kidney transplant evaluation. (
  • Schaffer JM, Chiu P, Singh SK, Oyer PE, Reitz BA, Mallidi HR. Heart and combined heart-kidney transplantation in patients with concomitant renal insufficiency and end-stage heart failure. (
  • Meanwhile Tarun himself is suffering from kidney failure. (
  • Live donor kidney transplantation has become a widely sought treatment by patients with end-stage renal failure. (
  • Nevertheless, live donor kidney transplantation may not be the realistic final solution to an international public health epidemic of renal failure that is the result of an aging population of patients that have had inadequate preventive medical care. (
  • Kidney failure patients-particularly blacks and those living in poor neighborhoods-who take part in an education program are more likely to get evaluated for a kidney transplant. (
  • Requiring a formal patient education class may help reduce disparities in kidney failure patients' access to kidney transplantation. (
  • Kidney transplantation is the preferred treatment for kidney failure. (
  • The researchers retrospectively examined information from 1,126 kidney failure patients who were referred for kidney transplant evaluation between 2005 and 2008. (
  • There is specific concern that some patients who undergo combined liver and kidney transplantation may have reversible renal failure. (
  • Did you know that African Americans are 3 times more likely to experience kidney failure? (
  • Washington, DC (May 22, 2014) -- Compared with long and frequent home hemodialysis, kidney transplantation may allow kidney failure patients to be successfully treated and to live longer, but it may also increase their risk of being hospitalized within the first year. (
  • Many studies have shown that kidney failure patients can receive many benefits from home hemodialysis that is done more often and for a longer stretch of time than is typically done in dialysis centers. (
  • Kidney transplant patients had a 55% to 61% (depending on organ donor type) reduced risk of treatment failure or death during the study compared with patients on long and frequent home hemodialysis. (
  • Kidney transplant patients had a reduced risk of treatment failure or premature death compared with patients on long and frequent home hemodialysis. (
  • Kidney failure is on the rise and currently afflicts 2 million people worldwide. (
  • There are thousands of patients with kidney failure who lack access to kidney transplantation, and disparities persist in terms of race, age, sex, and other patient characteristics. (
  • There have been tremendous advances in our ability to support kidney failure with various forms of dialysis, medication, diet and replacement of the failed kidneys through transplantation," explains Dr. Roberti. (
  • These are the most common causes of kidney failure in children from birth to age 4. (
  • These are the most common cause of kidney failure in children between ages 5 and 15. (
  • The most common cause of kidney failure in children between ages 15 and 19. (
  • T he treatment alternatives available to Australians with endstage kidney failure are dialysis, transplantation or no active treatment. (
  • The last of these options allows kidney failure to progress spontaneously to uraemia and death. (
  • METHOD AND PROCEDURES] One hundred and seventy-five patients with renal failure were performed kidney transplantation at our institution between April 2004 and September 2010. (
  • She past away seven years ago from kidney failure. (
  • Kidney failure is caused by variety of factors resulting in damage of the nephrons, which are the most important functioning unit of the kidneys. (
  • Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates," Transplantation , vol. 89, no. 11, pp. 1385-1390, 2010. (
  • This study provides some evidence to test an intervention of a patient education program for potential transplant candidates in a randomized controlled study to examine whether this improves access to kidney transplantation for poor or minority patients," said Dr. Patzer. (
  • Of the more than 100,000 candidates on the kidney transplant waiting list in the U.S., approximately 30 percent are on inactive status. (
  • They then determined the cumulative incidence of conversion to active waitlist status, death and delisting before conversion among 84,783 temporarily inactive adult kidney candidates from 2004 to 2012. (
  • Here, we performed ABO genotyping in blood samples, analyzed grouping discrepancies, and investigated the weak A subgroup frequency in kidney transplantation candidates. (
  • Two patients had received cadaveric kidneys and the others had received kidneys from living donor. (
  • However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. (
  • HCV-infected kidneys function just as well as uninfected kidneys throughout the year after transplantation. (
  • Sixty-one percent of all patients were men+ADs- median age (interquartile range +AFs-IQR+AF0-) was 46 years (35-56 years)+ADs- median (IQR) pretransplant BMI was 23.0 kg/m (20.8-25.6 kg/m)+ADs- 1 year after transplantation, the median (IQR) BMI had increased 1.6 kg/m (0.3-3.2 kg/m) and median (IQR) follow-up time was 8.3 years (5.3-12.0 years). (
  • To receive news and publication updates for Journal of Transplantation, enter your email address in the box below. (
  • Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production," American Journal of Transplantation , vol. 9, no. 1, pp. 201-209, 2009. (
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (
  • This 6th edition remains the balanced reference you need to stay apprised of issues important to successful kidney transplantation. (
  • The Herrick twin brothers were the subjects of the world's first successful kidney transplant, Ronald being the donor. (
  • Dialysis treatment can be discontinued after successful kidney transplantation. (
  • Improved precision of ABO genotyping is crucial for successful kidney transplantation and reasonable organ allocation. (
  • Successful kidney transplantation, results in near normalization of the antioxidant status and lipid metabolism by eliminating free radicals despite the surge of oxidative stress caused by the surgical procedure and ischemic injury to the organ during the operation. (
  • For patient education information, see Kidney Transplant and the Mayo Clinic's kidney transplant information Web page. (
  • Dorry Segev, MD, PhD (Johns Hopkins University School of Public Health) and his colleagues conducted a study to understand the concerns and perceived barriers that dialysis patients have about pursuing transplantation, and what patient characteristics are associated with such concerns. (
  • We recommend that patients with limited English proficiency who are in need of a kidney transplant use patient advocates who are English-proficient during transplant clinic visits and always use interpreters to get all of their questions answered. (
  • Measuring Patient Knowledge of Kidney Transplantation: An In. (
  • Nevertheless, there are widely recognized disparities in access to each of the required steps preceding receipt of a kidney transplant, including provision of patient transplant education. (
  • 2 Nevertheless, the death rate on dialysis is higher than after transplantation even after adjusting for patient characteristics. (
  • The largest kidney patient charity in the UK. (
  • It is divided in 4 modules: 1) Before the transplant 2) The surgical procedures and the challenged patient, including the patient with diabetes 3) Early challenges 4) Late challenges after transplantation. (
  • The benefit of enzyme-replacement therapy (ERT) in kidney transplanted Fabry patients has been controversially discussed and long-term trials focusing on the effectiveness of agalsidase in this patient population are needed. (
  • Ureteral stents are associated with reduced risk of ureteral complications after kidney transplantation: a large single center experience. (
  • Surgical complications after kidney transplantation. (
  • INTRODUCTION] Symptomatic lymphocele is one of the most frequent complications after kidney transplantation and belongs to the family of perirenal fluid collections such as hematoma and urinoma. (
  • They merged Organ Procurement and Transplantation Network/United Network for Organ Sharing data with zip code socioeconomic data from the 2000 U.S. census. (
  • Altogether these results question whether routine procurement biopsies result in discarding kidneys that could be acceptable for many of the patients who die waiting for a kidney transplant," he added. (
  • An update to the Organ Procurement and Transplantation Network policy stipulates dual confirmation of the donor A or AB subtype. (
  • In 2018, we celebrated 50 years as San Diego region's first kidney transplantation program. (
  • Since September 2018, most HCV-infected kidneys were transplanted into patients without the infection. (
  • change in the use of HCV-infected kidneys: until September 2018, most HCV-infected kidneys were transplanted into patients with pre-existing HCV, but since September 2018, the majority of HCV-infected kidneys were transplanted into patients without the infection. (
  • Various methods to increase the supply of available kidneys have proven to be either unworkable or insufficient to significantly allay the shortage. (
  • Unfortunately, because of a shortage of available kidneys, there is a long waitlist to receive a transplant, and approximately 5000 patients in the Unites States die each year waiting for a kidney transplant. (
  • Join The Cato Institute for this panel discussion, which will explore various ways to alleviate the critical shortage of available kidneys. (
  • To increase the success rate, a two-stage procedure was performed, i.e. the left native kidney was removed at the time of grafting and the right native kidney was left in place until day 7, when the right nephrectomy was performed. (
  • In order to provide the best care for your child, providers on the Kidney Transplant team closely collaborate with departments and specialties across Children's National. (
  • Talk with a member of the Virtua kidney and pancreas transplant team. (
  • We will then schedule a date for you to come to ECMC for a full day of education, testing, and meeting with the kidney transplant team. (
  • In the past the most appropriate time for transplantation from a living donor was after the patient's start the renal function replacement therapy. (
  • Zalawadiya SK, Wigger M, DiSalvo T, Haglund N, Maltais S, Lindenfeld J. Mechanical circulatory support and simultaneous heart-kidney transplantation: An outcome analysis. (
  • The team found that biopsy-reported kidney injury was modestly associated with a delay in organ function in the first week after transplantation, but only for a subgroup of donor kidneys already known to be at high risk for this early outcome. (
  • At her suggestion, he applied and was accepted to Ian Aird's surgical unit at the Postgraduate Hospital, Hammersmith, as a researcher in organ transplantation, investigating the outcome of dog kidney allografts. (