The transference of a kidney from one human or animal to another.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The transference of a part of or an entire liver from one human or animal to another.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transference of a pancreas from one human or animal to another.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
A dead body, usually a human body.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The transference of a heart from one human or animal to another.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Pathological processes of the KIDNEY or its component tissues.
Prospective patient listings for appointments or treatments.
The transference of either one or both of the lungs from one human or animal to another.
Transplantation of an individual's own tissue from one site to another site.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Elements of limited time intervals, contributing to particular results or situations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transference of an organ between individuals of the same species or between individuals of different species.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Tissue, organ, or gamete donation intended for a designated recipient.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
The return of a sign, symptom, or disease after a remission.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The period following a surgical operation.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
Excision of kidney.
Cystic mass containing lymph from diseased lymphatic channels or following surgical trauma or other injury.
A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
An institutional policy of granting authority to health personnel to perform procedures on patients or to remove organs from cadavers for transplantation unless an objection is registered by family members or by the patient prior to death. This also includes emergency care of minors without prior parental consent.
Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Tumors or cancers of the KIDNEY.
An insoluble support for an ANTIGEN or ANTIBODIES that is used in AFFINITY CHROMATOGRAPHY to adsorb the homologous antibody or antigen from a mixture. Many different substances are used, among them SEPHAROSE; GLUTARALDEHYDE; copolymers of ANHYDRIDES; polyacrylamides, etc.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Differences in access to or availability of medical facilities and services.
Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Disease having a short and relatively severe course.
Occasions to commemorate an event or occasions designated for a specific purpose.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Transplantation between animals of different species.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Therapy with two or more separate preparations given for a combined effect.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Societal or individual decisions about the equitable distribution of available resources.
Partial or total replacement of the CORNEA from one human or animal to another.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
Kidney disorders with autosomal dominant inheritance and characterized by multiple CYSTS in both KIDNEYS with progressive deterioration of renal function.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Groups of individuals whose putative ancestry is from native continental populations based on similarities in physical appearance.
A country in northern Africa, bordering the Mediterranean Sea, between Egypt, Tunisia, and Algeria, having southern border with Chad, Niger, and Sudan. Its capital is Tripoli.
Testing of immune status in the diagnosis and therapy of cancer, immunoproliferative and immunodeficiency disorders, and autoimmune abnormalities. Changes in immune parameters are of special significance before, during and following organ transplantation. Strategies include measurement of tumor antigen and other markers (often by RADIOIMMUNOASSAY), studies of cellular or humoral immunity in cancer etiology, IMMUNOTHERAPY trials, etc.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
Pathological processes of the LIVER.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Short thick veins which return blood from the kidneys to the vena cava.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Antibodies produced by a single clone of cells.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Payment, or other means of making amends, for a wrong or injury.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.
A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
A condition of an abnormally low level of PHOSPHATES in the blood.
Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Consideration and concern for others, as opposed to self-love or egoism, which can be a motivating influence.
A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.
Antibodies obtained from a single clone of cells grown in mice or rats.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Surgical procedure involving either partial or entire removal of the spleen.
The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
An island in the Greater Antilles in the West Indies, south of Florida. With the adjacent islands it forms the Republic of Cuba. Its capital is Havana. It was discovered by Columbus on his first voyage in 1492 and conquered by Spain in 1511. It has a varied history under Spain, Great Britain, and the United States but has been independent since 1902. The name Cuba is said to be an Indian name of unknown origin but the language that gave the name is extinct, so the etymology is a conjecture. (From Webster's New Geographical Dictionary, 1988, p302 & Room, Brewer's Dictionary of Names, 1992, p132)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Progenitor cells from which all blood cells derive.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Inferior and external epigastric arteries arise from external iliac; superficial from femoral; superior from internal thoracic. They supply the abdominal muscles, diaphragm, iliac region, and groin. The inferior epigastric artery is used in coronary artery bypass grafting and myocardial revascularization.

Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. (1/8017)

BACKGROUND: Although Fas on pancreatic islets promotes autoimmune diabetes in mice, the role of Fas expression on kidney parenchymal cells during autoimmune disease is unknown. METHODS: To determine whether Fas on renal parenchymal cells promotes autoimmune renal destruction, we compared apoptosis and pathology in Fas-intact and Fas-deficient kidneys in an autoimmune milieu. For this purpose, we transplanted single, normal kidneys from MRL-++ (Fas-intact) mice (3 months of age) into age-matched, congenic MRL-Faslpr (Fas-deficient) recipients after removal of nephritic kidneys. These Fas-intact kidneys were compared with Fas-deficient nephritic kidneys. RESULTS: There is a progressive increase of FasL on kidney-infiltrating cells and Fas and FasL on renal parenchymal cells in MRL-++ kidneys during engraftment (0, 2, 4-6, and 8 weeks). By comparison, we detected an increase in FasL in MRL-Faslpr kidneys (3 to 5 months of age), whereas Fas was not detectable. The engagement of T cells bearing FasL with Fas expressing tubular epithelial cells (TECs) induced TEC apoptosis in vitro. However, apoptosis and pathology were similar in kidneys (MRL-++, 8 weeks postengraftment vs. MRL-Faslpr, 5 months) with equivalent amounts of FasL-infiltrating cells or FasL TECs, regardless of Fas on renal parenchymal cells. CONCLUSION: The expression of Fas on renal parenchymal cells does not increase apoptosis or promote renal disease in MRL-++ mice. We speculate that the autoimmune milieu evokes mechanisms that mask, counter, or pre-empt Fas-FasL-initiated apoptosis in MRL kidneys.  (+info)

Sodium reabsorption and distribution of Na+/K+-ATPase during postischemic injury to the renal allograft. (2/8017)

BACKGROUND: A loss of proximal tubule cell polarity is thought to activate tubuloglomerular feedback, thereby contributing to glomerular filtration rate depression in postischemic acute renal failure (ARF). METHODS: We used immunomicroscopy to evaluate the segmental distribution of Na+/K+-ATPase in tubules of recipients of cadaveric renal allografts. Fractional excretion (FE) of sodium and lithium was determined simultaneously. Observations were made on two occasions: one to three hours after graft reperfusion (day 0) and again on post-transplant day 7. An inulin clearance below or above 25 ml/min on day 7 was used to divide subjects into groups with sustained (N = 15) or recovering (N = 16) ARF, respectively. RESULTS: In sustained ARF, the fractional excretion of sodium (FENa) was 40 +/- 6% and 11 +/- 5%, and the fractional excretion of lithium (FELi) was 76 +/- 5% and 70 +/- 2% on days 0 and 7, respectively. Corresponding findings in recovering ARF were 28 +/- 2% and 6 +/- 2% for the FENa and 77 +/- 4% and 55 +/- 3% (P < 0.05 vs. sustained) for FELi. Na+/K+-ATPase distribution in both groups was mainly basolateral in distal straight and convoluted tubule segments and collecting ducts. However, Na+/K+-ATPase was poorly retained in the basolateral membrane of proximal convoluted and straight tubule segments in sustained and recovering ARF on both days 0 and 7. CONCLUSIONS: We conclude that loss of proximal tubule cell polarity for Na+/K+-ATPase distribution is associated with enhanced delivery of filtered Na+ to the macula densa for seven days after allograft reperfusion. Whether an ensuing activation of tubuloglomerular feedback is an important cause of glomerular filtration rate depression in this form of ARF remains to be determined.  (+info)

Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients. (3/8017)

BACKGROUND: Hyperhomocysteinemia is an established, independent risk factor for vascular disease morbidity and mortality. The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T has been shown to result in increased total homocysteine concentrations on the basis of low folate levels caused by a decreased enzyme activity. The effect of this polymorphism on total homocysteine and folate plasma levels in renal transplant patients is unknown. METHODS: We screened 636 kidney graft recipients for the presence of the MTHFR C677T gene polymorphism. The major determinants of total homocysteine and folate plasma concentrations of 63 patients, who were identified to be homozygous for this gene polymorphism compared with heterozygotes (N = 63), and patients with wild-type alleles (N = 63), who were matched for sex, age, glomerular filtration rate (GFR), and body mass index, were identified by analysis of covariance. The variables included sex, age, GFR, body mass index, time since transplantation, folate and vitamin B12 levels, the use of azathioprine, and the MTHFR genotype. To investigate the impact of the kidney donor MTHFR genotype on total homocysteine and folate plasma concentrations, a similar model was applied in 111 kidney graft recipients with stable graft function, in whom the kidney donor C677T MTHFR gene polymorphism was determined. RESULTS: The allele frequency of the C677T polymorphism in the MTHFR gene was 0.313 in the whole study population [wild-type (CC), 301; heterozygous (CT), 272; and homozygous mutant (TT), 63 patients, respectively] and showed no difference in the patient subgroups with various renal diseases. The MTHFR C677T gene polymorphism significantly influenced total homocysteine and folate plasma concentrations in renal transplant recipients (P = 0.0009 and P = 0.0002, respectively). Furthermore, a significant influence of the GFR (P = 0.0001), folate levels (P = 0.0001), age (P = 0.0001), body mass index (P = 0.0001), gender (P = 0.0005), and vitamin B12 levels (P = 0.004) on total homocysteine concentrations was observed. The donor MTHFR gene polymorphism had no influence on total homocysteine and folate levels. Geometric mean total homocysteine levels in patients homozygous for the mutant MTHFR allele were 18.6 micromol/liter compared with 14.6 micromol/liter and 14.9 micromol/liter in patients heterozygous for the MTHFR gene polymorphism and those with wild-type alleles (P < 0.05 for TT vs. CT and CC). Geometric mean folate levels were lower in CT and TT patients (11.2 and 10.2 nmol/liter) compared with CC patients (13.6 nmol/liter, P < 0.05 vs. CT and TT). CONCLUSIONS: This study demonstrates that homozygosity for the C677T polymorphism in the MTHFR gene significantly increases total homocysteine concentrations and lowers folate levels in kidney graft recipients, even in patients with excellent renal function (GFR more than median). These findings have important implications for risk evaluation and vitamin intervention therapy in these patients who carry an increased risk for the development of cardiovascular disease.  (+info)

Flow-mediated vasodilation and distensibility of the brachial artery in renal allograft recipients. (4/8017)

BACKGROUND: Alterations of large artery function and structure are frequently observed in renal allograft recipients. However, endothelial function has not yet been assessed in this population. METHODS: Flow-mediated vasodilation is a useful index of endothelial function. We measured the diameter and distensibility of the brachial artery at rest using high-resolution ultrasound and Doppler frequency analysis of vessel wall movements in the M mode. Thereafter, changes in brachial artery diameter were measured during reactive hyperemia (after 4 min of forearm occlusion) in 16 cyclosporine-treated renal allograft recipients and 16 normal controls of similar age and sex ratio. Nitroglycerin-mediated vasodilation was measured to assess endothelium-independent vasodilation. Brachial artery blood pressure was measured using an automatic sphygmomanometer, and brachial artery flow was estimated using pulsed Doppler. RESULTS: Distensibility was reduced in renal allograft recipients (5.31 +/- 0. 74 vs. 9.10 +/- 0.94 x 10-3/kPa, P = 0.003, mean +/- sem), while the brachial artery diameter at rest was higher (4.13 +/- 0.14 vs. 3.25 +/- 0.14 mm, P < 0.001). Flow-mediated vasodilation was significantly reduced in renal allograft recipients (0.13 +/- 0.08 vs. 0.60 +/- 0.08 mm or 3 +/- 2 vs. 19 +/- 3%, both P < 0.001). However, nitroglycerin-mediated vasodilation was similar in renal allograft recipients and controls (0.76 +/- 0.10 vs. 0.77 +/- 0.09 mm, NS, or 19 +/- 3 vs. 22 +/- 2%, NS). There were no significant differences in brachial artery flow at rest and during reactive hyperemia between both groups. The impairments of flow-mediated vasodilation and distensibility in renal allograft recipients remained significant after correction for serum cholesterol, creatinine, parathyroid hormone concentrations, end-diastolic diameter, as well as blood pressure levels, and were also present in eight renal allograft recipients not treated with cyclosporine. Flow-mediated vasodilation was not related to distensibility in either group. CONCLUSIONS: The results show impaired endothelial function and reduced brachial artery distensibility in renal allograft recipients. The impairments of flow-mediated vasodilation and distensibility are not attributable to a diminished brachial artery vasodilator capacity, because endothelium-independent vasodilation was preserved in renal allograft recipients.  (+info)

A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (5/8017)

BACKGROUND: Between September 20, 1995 and September 20, 1997, 208 adult patients undergoing renal transplantation were randomized to receive tacrolimus/prednisone (n=106) or tacrolimus/prednisone/mycophenolate mofetil (n=102), with the goal of reducing the incidence of rejection. METHODS: The mean recipient age was 50.7+/-13.7 years. Sixty-three (30.3%) patients were 60 years of age or older at the time of transplantation. The mean donor age was 34.5+/-21.7 years. The mean cold ischemia time was 30.5+/-9.2 hr. The mean follow-up is 15+/-7 months. RESULTS: The overall 1-year actuarial patient survival was 94%; the overall 1-year actuarial graft survival was 87%. When the patient and graft survival data were stratified to recipients under the age of 60 who did not have delayed graft function, the overall 1-year actuarial patient survival was 97%, and the corresponding 1-year actuarial graft survival was 93%. There were no differences between the two groups. The overall incidence of rejection was 36%; in the double-therapy group, it was 44%, whereas in the triple therapy group, it was 27% (P=0.014). The mean serum creatinine was 1.6+/-0.8 mg/dl. A total of 36% of the successfully transplanted patients were taken off prednisone; 32% of the patients were taken off antihypertensive medications. The incidence of delayed graft function was 21%, the incidence of cytomegalovirus was 12.5%, and the initial and final incidences of posttransplant insulin-dependent diabetes mellitus were 7.0% and 2.9%; again, there was no difference between the two groups. CONCLUSIONS: This trial suggests that the combination of tacrolimus, steroids, and mycophenolate mofetil is associated with excellent patient and graft survival and a lower incidence of rejection than the combination of tacrolimus and steroids.  (+info)

The spouse as a kidney donor: ethically sound? (6/8017)

A shortage of cadaver donor organs requires transplant units to examine all possible alternatives. Transplantation from living donors accounts for only approximately 10% of kidney transplants in the UK. Recent studies have shown that the results of kidney transplantation between spouses are at least as good as those of well-matched cadaver organs, but very few transplants of this type have been performed in this country so far. As part of the assessment process, the proposed donor and recipient are required to provide written statements about the issues. We reproduce here the personal statements made by one of our patients and his wife: we believe that the statements support our contention that spousal transplantation is ethically justifiable and should be more widely available. We report our early experience in Bristol with seven kidney transplants from spousal donors and we encourage other renal units in this country and elsewhere to consider this method of improving the prospects of kidney transplantation for their patients.  (+info)

Incidence of analgesic nephropathy in Berlin since 1983. (7/8017)

BACKGROUND: Phenacetin was removed from the German market in 1986 and was replaced mainly in analgesic compounds by acetaminophen. Our objective was to examine the effect of this measure on the incidence of analgesic nephropathy in light of the changes in other end-stage renal diseases. METHODS: We therefore compared the proportion of renal diseases in all patients starting dialysis treatment during three 18-month periods: 4/1982-9/1983 (n=57); 1/1991-6/1992 (n=81); and 10/1995-3/1997 (n=76). RESULTS: On the one hand, the proportion of end-stage analgesic nephropathy decreased significantly from 30% in 1981-1982 to 21% in 1991-1992 and 12% in 1995-1997 (P=0.01). On the other hand, type II diabetes increased significantly from 7% to 22% (P=0.01) and 29%, (P=0.001). Using the chi2 distribution test to analyze the frequencies of seven diseases at three different time intervals, however, showed that the changes in renal-disease proportions between 1982-1983, 1991-1992 and 1995-1997 were not significantly independent. There was a significant median age increase from 52 years (CI0.95 44-58) in 1982-1983 to 63 (CI0.95 55-67) in 1991-1992 and 63 (CI0.95 60-66) in 1995-1997 (P=0.003) for all patients starting dialysis but not for those with analgesic nephropathy [59 (55-71) vs 64 (53-67) and 61 (50-72); n.s.]. CONCLUSION: The decrease of end-stage analgesic nephropathy since 1983 may be partially due to the removal of phenacetin from the German market in 1986. However, considering the general increase in numbers of dialysis patients, their higher age and the increased incidence of type II diabetes, the decrease in analgesic nephropathy is not a statistically significant independent variable. Altered admittance policies for dialysis treatment have yielded a new pattern of renal-disease proportion which interferes with changes in the incidence of analgesic nephropathy.  (+info)

Studies on structural changes of the carotid arteries and the heart in asymptomatic renal transplant recipients. (8/8017)

BACKGROUND: The present study was designed to characterize early structural changes of large arteries in renal transplant recipients with no clinical evidence of cardiovascular disease and normal blood pressure values, and to analyse the relationship between arterial alterations and those of the heart. METHODS: Intima media thickness and atherosclerotic plaques of the carotid arteries as well as left ventricular geometry and function were examined in 35 asymtomatic renal transplant recipients and 29 age- and sex-matched healthy controls by high resolution B-mode ultrasound and by echocardiography. RESULTS: Intima-media thickness of the carotid arteries was significantly higher in renal transplant recipients (1.21+/-0.08 mm) than in healthy controls (0.74+/-0.04 mm) (P<0.001). Atherosclerotic plaques were found in the majority of renal transplant recipients (71% vs 14% in healthy controls, P<0.001). Left ventricular mass index was significantly increased in the group of renal transplant recipients (264+/-13 g, 146+/-7 g/m2) when compared with healthy controls (155+/-8 g, 83+/-4 g/m2) (P<0.001). Multiple regression analysis in renal transplant recipients showed that intima media thickness of the carotid arteries was significantly related to left ventricular mass index (P<0.02), but not to age, blood pressure, body mass index, serum creatinine, cholesterol and lipoprotein (a) levels. In the group of healthy controls, intima-media thickness of the carotid artery was related to age (P<0.002), but not to left ventricular mass index or the other independent variables. CONCLUSIONS: The present study documents pronounced intima-media thickening in asymptomatic renal transplant recipients. Atherosclerotic lesions are present in most renal transplant recipients with no clinical evidence of cardiovascular disease. We observed a parallelism between arterial wall thickening and left ventricular hypertrophy, although blood pressure levels were normal during haemodialysis therapy and after renal transplantation.  (+info)

TY - JOUR. T1 - Overcoming immunological barriers to living donor kidney transplantation at Stanford University Medical Center. AU - Ladner, Daniela Patricia. AU - Busque, Stephan. AU - Melcher, Marc Lee. PY - 2008/4/10. Y1 - 2008/4/10. N2 - Aims: The outcome of living donor kidney transplantation (LDKT) is better than the outcome of deceased kidney transplantation, and the deceased donor pool has been slow to expand. Although recipients may have willing and healthy donors, immunological barriers can still prevent successful kidney transplantation. Therefore, we studied kidney transplant candidates at our institution with incompatible living donors to understand the barriers to LDKT and to develop strategies to overcome them. Methods: We identified candidates in our programme who have potential donors that have been rejected either because of ABO incompatibility or because of a positive cross-match. Age, blood type, panel reactive antibody (PRA), donor blood type, donor age and cross-match ...
TY - JOUR. T1 - Unusual presentations of BK virus infections in pediatric renal transplant recipients. AU - Drake, Keri A.. AU - Najera, Lydia. AU - Reed, Robyn C.. AU - Verghese, Priya S.. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2013/2. Y1 - 2013/2. N2 - BKV has emerged as a significant pathogen in the field of transplantation, predominantly causing BKV nephropathy in renal transplant recipients and hemorrhagic cystitis in HSCT recipients. However, case reports describe more diverse complications, and we too present three unusual cases of BKV infections in pediatric renal transplant recipients. First, we describe a case of biopsy-proven renal damage secondary to BKV prior to the onset of viremia, demonstrating that BKV nephropathy can occur without preceding viremia. We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. Therefore, we conclude that BKV ...
TY - JOUR. T1 - Posttransplant diabetes mellitus in pediatric renal transplant recipients. T2 - A report of The North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). AU - Al-Uzri, Amira. AU - Stablein, Donald M.. AU - Cohn, Richard A.. PY - 2001/9/27. Y1 - 2001/9/27. N2 - Background. The incidence of renal post transplant diabetes mellitus (PTDM) in adults varies from 3-46%. Methods. We did a retrospective analysis of 1365 children in The North American Pediatric Renal Transplant Cooperative Study with renal transplant (Tx) reported between January 92 and July 1997. PTDM, defined as ,2 weeks of insulin therapy after Tx, developed in 36 patients. A control group of 153/1329 non-PTDM patients was selected and matched for age at Tx and primary diagnosis. Results. African-Americans were overrepresented (36.1 vs. 17.6%, P=0.017) and Hispanics were underrepresented (5.6 vs. 26.1%, P=0.019) among cases. Although prednisone dose 30 days post-Tx was higher among cases (0.89 mg/kg/day) ...
Purpose To determine the impact of transplant nephrectomy on morbidity and mortality and HLA immunization. Methods All patients who underwent transplant nephrectomy in our centre between 2000 and 2016 were included in this study. A total of 2822 renal transplantations and 180 transplant nephrectomies were performed during this period. Results The indications for transplant nephrectomy were graft intolerance syndrome: 47.2%, sepsis: 22.2%, vascular thrombosis: 15.5%, tumour: 8.3% and other 6.8%. Transplant nephrectomies were performed via an intracapsular approach in 61.7% of cases. The blood transfusion rate was 50%, the morbidity rate was 38% and the mortality rate was 3%. Transplant nephrectomies more than 12 months after renal transplant failure were associated with more complications (p = 0.006). Transfusions in the context of transplant nephrectomy had no significant impact on alloimmunization. Conclusion The risk of bleeding, and therefore of transfusion, constitutes the major challenge of this
TY - JOUR. T1 - Non-immunological risk factors associated with chronic allograft nephropathy following kidney transplantation. AU - Shiroki, Ryoichi. AU - Hoshinaga, Kiyotaka. PY - 2002/11/1. Y1 - 2002/11/1. N2 - Although the precise mechanisms are unclear, not only alloantigen-dependent but also antigen-independent factors are generally thought to influence the development of chronic allograft nephropathy (CAN). Among the non-immunological determinants, there are various factors related with donor, recipient and graft procurement. As donor factors, age and cause of death were demonstrated to be significantly independent in long-term graft survival of cadaveric kidney transplantation. Grafts from aged donors and from donors with athelosclerosis showed poor prognosis on graft survival. Regarding recipient factors, cardiovascular complications, as hypertension and hyperlipidemia, were responsible for graft as well as patient survival. In addition, CMV infection and drug nephrotoxicity were also ...
Five patients who were recently recovered from Covid 19 underwent successful Kidney transplantation at VPS Lakeshore hospital. After the surgeries, all the patients are doing well.
kidney information, kidney education, kidney transplant information, Kidney Transplantation, Pre kidney transplant information, Paired kidney donation, Pre-emptive kidney transplant, post kidney Transplantation care, post kidney Transplantation drugs, post kidney Transplantation medications, post kidney Transplantation precautions, Precautions after Kidney Transplant, Deceased kidney transplantation, Cadaveric kidney transplantation, Brain death, what is brain death, diagnosis of brain death, information after kidney transplant, kidney transplant procedure, kidney transplant rejection, kidney transplant surgery, renal transplantation, kidney donation, kidney removal, organ donation, kidney transplantation indications, kidney transplantation advantages, kidney transplantation disadvantages, donor selection for kidney transplantation, who can donate kidney, post kidney transplantation complications, guidelines for transplanted kidney
kidney information, kidney education, kidney transplant information, Kidney Transplantation, Pre kidney transplant information, Paired kidney donation, Pre-emptive kidney transplant, post kidney Transplantation care, post kidney Transplantation drugs, post kidney Transplantation medications, post kidney Transplantation precautions, Precautions after Kidney Transplant, Deceased kidney transplantation, Cadaveric kidney transplantation, Brain death, what is brain death, diagnosis of brain death, information after kidney transplant, kidney transplant procedure, kidney transplant rejection, kidney transplant surgery, renal transplantation, kidney donation, kidney removal, organ donation, kidney transplantation indications, kidney transplantation advantages, kidney transplantation disadvantages, donor selection for kidney transplantation, who can donate kidney, post kidney transplantation complications, guidelines for transplanted kidney
Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P lt 0.001), but more HDL 3a (P lt 0.01) and 3b (P lt 0.001) subclasses. They also had increased sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05) levels. The proportion ...of the HDL 3b ...
Advanced chronic kidney disease often results in adverse cardiovascular outcomes and is the leading cause of mortality in patients with end stage renal diseases (ESRD). There is much information about the effect of chronic kidney diseases (CKD) on the left ventricle (LV) chamber, but the right ventricle (RV) as a neglected chamber had not been evaluated precisely, in spite of its importance. The aim of this study was to evaluate the impact of successful kidney transplants on the RV systolic and diastolic function using the advanced method of 2D speckle tracking echocardiography and comparison with the conventional methods. The study included 48 patients with CKD who were eligible for kidney transplantation and underwent successful kidney transplantations. Right ventricular indices were evaluated, while RV function was focused by conventional methods and 2D speckle tracking echocardiography before the successful kidney transplant and 1 week, 1 month, and 3 months after the successful kidney transplant.
TY - JOUR. T1 - Effect of kidney transplantation on outcomes among patients with hepatitis C. AU - Roth, David. AU - Gaynor, Jeffrey J.. AU - Reddy, K. Rajender. AU - Ciancio, Gaetano. AU - Sageshima, Junichiro. AU - Kupin, Warren. AU - Guerra, Giselle. AU - Chen, Linda. AU - Burke, George W.. PY - 2011/6. Y1 - 2011/6. N2 - The long-term outcome of kidney transplantation in patients infected with hepatitis C virus (HCV) and end stage renal disease (ESRD) is not well described. We retrospectively identified 230 HCV-infected patients using enzyme immunoassay and nucleic acid testing obtained during the transplant evaluation. Of 207 patients who had a liver biopsy before transplant, 44 underwent 51 follow-up liver biopsies at approximately 5-year intervals either while on the waitlist for a kidney or after kidney transplantation. Advanced fibrosis was present in 10% of patients biopsied, identifying a population that may warrant consideration for combined liver-kidney transplantation. Kidney ...
Introduction: The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. However, the clinical significance of dnDSA in patients with a stable creatinine remains unclear. Methods: We performed a retrospective cohort study of 103 patients receiving a first, kidney alone transplant between 12/1/2007 and 12/31/2013. Inclusion criteria were age ,18 years old at the time of transplant and at least two years of DSA monitoring. All patients underwent DSA screening every 3 months post-transplant with additional testing as clinically indicated. No treatment was given for DSAs in the absence of biopsy-proven rejection. Results: 20 patients (19%) developed dnDSA in the setting of a stable creatinine and 13 patients (13%) developed dnDSA in the setting of an elevated creatinine. Median follow-up time post-transplant was 4.1 (IQR 2.9-5.7) years. In a Cox ...
By B.DULGUUN. The first kidney transplant procedure in 1996 by Mongolian doctors was unsuccessful. After ten years, State Honored Doctor L.Jambaljav and his colleagues from the Mongolian National Central Hospital No.1 successfully conducted a kidney transplant procedure. Currently, State Honored Doctor and Professor of Chronic Kidney Disease Clinic D.Nyamsuren is working as the head of the Kidney Transplant Center team at the National Central Hospital. He has been working with the team since the introduction of kidney transplantation in Mongolia and saved 79 lives. Below is an interview with D.Nyamsuren about kidney transplantation in Mongolia.. -Whats the current actual cost of kidney transplantation?. -The National Central Hospital No.1 conducts kidney transplantation for 12 million MNT. Eight million is paid by the Ministry of Health package and the rest by the patient. At our current price, this budget is not sufficient. The National Central Hospital No.1 is able to transplant kidneys for ...
TY - JOUR. T1 - Longitudinal measurement of physical activity following kidney transplantation. AU - Dontje, Manon L.. AU - de Greef, Mathieu. AU - Krijnen, Wim. AU - Corpeleijn, Eva. AU - Kok, T. AU - Bakker, S.J.. AU - Stolk, Ronald P.. AU - van der Schans, Cees. PY - 2014. Y1 - 2014. N2 - Purpose of this longitudinal observational study was to (i) examine the change of daily physical activity in 28 adult kidney transplant recipients over the first 12 months following transplantation; and (ii) to examine the change in metabolic characteristics and renal function. Accelerometer-based daily physical activity and metabolic- and clinical characteristics were measured at six wk (T1), three months (T2), six months (T3) and 12 months (T4) following transplantation. Linear mixed effect analyses showed an increase in steps/d (T1 = 6326 ± 2906; T4 = 7562 ± 3785; F = 3.52; p = 0.02), but one yr after transplantation only 25% achieved the recommended 10 000 steps/d. There was no significant increase in ...
TY - JOUR. T1 - The interaction between post-transplant anemia and allograft function in kidney transplantation. T2 - The Japan Academic Consortium of Kidney Transplantation-II study. AU - The Japan Academic Consortium of Kidney Transplantation (JACK). AU - Okumi, Masayoshi. AU - Okabe, Yasuhiro. AU - Unagami, Kohei. AU - Kakuta, Yoichi. AU - Iizuka, Junpei. AU - Takagi, Toshio. AU - Shirakawa, Hiroki. AU - Shimizu, Tomokazu. AU - Omoto, Kazuya. AU - Ishida, Hideki. AU - Nakamura, Masafumi. AU - Tanabe, Kazunari. N1 - Funding Information: We appreciate the support from Katsunori Shimada, Ph.D. (STATZ Institute, Inc., Tokyo, Japan), who provided expert assistance with statistical analyses.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background: The interaction between post-transplant anemia (PTA) and allograft function in kidney transplantation has not been evaluated directly. PTA, defined by WHO/AST criteria, was investigated in 1307 adult kidney transplant recipients between 2000 and 2015 (median ...
A three sequence, open-label, multi-center, prospective, study in stable kidney transplant patients to assess and compare the pharmacokinetics (Cmax, C24, and AUC), and safety of LCP-Tacro (tacrolimus) tablets versus Prograf (tacrolimus) capsules.. Stable kidney transplant patients who fulfill all I/E criteria will be enrolled and kept on Prograf for 7 days. Following a 24-hour PK study on Day 7 to determine pharmacokinetics for Prograf, all patients will be converted to once daily LCP-Tacro for 7 days with no dose changes allowed. On Day 14 and Day 21 a 24-hour LCP-Tacro PK study will be performed. On Day 22 patients will be converted back to their original twice daily dose of Prograf for a safety follow-up period of 30 days ending with a safety assessment on day 53. ...
Partial table of contents: A Short History of Renal Transplantation (R. Calne). Considerations in Organ Transplantation (R. Kerman). Pretransplantation and Posttransplantation Psychosocial Evaluation. (G. Wolff). Impact of Recipient Age on Renal Allograft Outcome (G. Arbus & D. Hebert). Steroid Withdrawal After Renal Transplantation (E. Ingulli & A. Tejani). Treatment of Acute Rejection (G. Offner). Urologic Complications in Renal Transplantation (O. Salvatierra). Noncompliance to Medical Regimens (B. Cole). Malignancy in Children (I. Penn). Long-Term Outcome of Kidney Transplantation in Children (D. Potter). Index.Pediatric Renal Transplantation, 1 was published 1994 under ISBN 9780471591207 and ISBN 0471591203. [read more] ...
PRIMARY OBJECTIVES:. I. To assess human papillomavirus (HPV) vaccine-type-specific seroconversion rates at 12-months post-transplantation among kidney transplant recipients who receive ,= 1 doses of the recombinant human papillomavirus nonavalent vaccine (Gardasil 9 HPV vaccine) ,= 30 days prior to transplantation.. SECONDARY OBJECTIVES:. I. To evaluate the following in adult kidney transplant recipients who receive ,= 1 doses of the Gardasil 9 HPV vaccine prior to transplantation:. Ia. HPV vaccine-type-specific seroconversion rates at 12-months post-transplantation.. Ib. Persistence and stability of HPV vaccine-type-specific geometric mean titers (GMT) at 6 and 12-months post-transplantation, and rise in HPV vaccine-type-specific GMT at the 13 month post-transplant visit.. Ic. Vaccine safety profile and allograft rejection/opportunistic infections stratified by number of vaccine doses and time between the last vaccine dose and the transplant procedure.. Id. HPV detection in self-collected ...
BACKGROUND: C-reactive protein (CRP) is a predictor of coronary heart disease, total mortality and chronic allograft nephropathy in renal transplant recipients. The determinants of CRP have been investigated in the general population, but not in renal transplant recipients. CRP might reflect metabolic aberrations in association with central obesity and systemic atherosclerosis. However, it may also reflect a low-grade immune-mediated response to the graft. In this study we investigated the factors associated with CRP in a renal transplant population. METHODS: Between August 2001 and July 2003, renal transplant recipients with a functioning graft for more than 1 year (n = 847) were eligible for investigation at their next visit to the outpatient clinic. A total of 606 patients (55% male, aged 51+/-12 years) participated at a median (interquartile range) time of 6.0 (2.6-11.4) years post-transplant. RESULTS: Median CRP concentration was 2.0 (0.80-4.8) mg/l and mean 24 h creatinine clearance was 62+/-22 ml
The ultimate goal of clinical transplantation is for the recipients to achieve long-term survival, with continuing graft function, that is equivalent to that of the age-matched general population. We studied subsequent outcome in kidney transplant recipients with 10 years of graft function. In all, 2202 kidney transplant recipients survived with graft function ,10 years. For 10-year survivors, the actuarial 25-year patient survival rate for primary transplant living donor (LD) recipients was 57%; graft survival, 43%. For primary transplant deceased donor (DD) recipients, the actuarial 25-year patient survival rate was 39%; graft survival, 27%. The two major causes of late graft loss were death (with graft function) and chronic allograft nephropathy (tubular atrophy and interstitial fibrosis). The two major causes of death with function were cardiovascular disease (CVD) and malignancy. For nondiabetic recipients, the mean age at death with function from CVD was 54 ± 13 years; for diabetic ...
PubMed journal article: Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. Download Prime PubMed App to iPhone, iPad, or Android
Uremia has long been recognized to disrupt the normal physiology of numerous organs, including the heart (2,3). Over the last 30 years, echocardiography studies have found adverse changes in cardiac structure and function associated with end-stage renal disease (ESRD), which is collectively termed uremic cardiomyopathy. These cardiac abnormalities, including left ventricular hypertrophy and systolic dysfunction, are common in hemodialysis and are associated with an increased risk of adverse clinical outcomes (4). However, the precise nature of the uremic mediators of cardiac dysfunction remain elusive. Kidney transplantation is the treatment of choice for selected patients with ESRD. A successful kidney transplantation improves the quality of life and reduces the mortality risk for most patients compared with maintenance dialysis (5). However, 50% to 60% of deaths among kidney transplantation recipients are directly attributable to cardiovascular disease. In addition, death from cardiovascular ...
TY - JOUR. T1 - Early renal function recovery and long-term graft survival in kidney transplantation. AU - Wan, Susan S.. AU - Cantarovich, Marcelo. AU - Mucsi, I.. AU - Baran, Dana. AU - Paraskevas, Steven. AU - Tchervenkov, Jean. PY - 2016/5/1. Y1 - 2016/5/1. N2 - Following kidney transplantation (KTx), renal function improves gradually until a baseline eGFR is achieved. Whether or not a recipient achieves the best-predicted eGFR after KTx may have important implications for immediate patient management, as well as for long-term graft survival. The aim of this cohort study was to calculate the renal function recovery (RFR) based on recipient and donor eGFR and to evaluate the association between RFR and long-term death-censored graft failure (DCGF). We studied 790 KTx recipients between January 1990 and August 2014. The last donor SCr prior to organ procurement was used to estimate donor GFR. Recipient eGFR was calculated using the average of the best three SCr values observed during the first ...
TY - THES. T1 - Kidney transplantation from donors after cardiac death : studies on the pathophysiology and prevention of ischemic acute kidney injury and on the long-term outcome after transplantation. AU - Snoeijs, M.G.. PY - 2010/1/1. Y1 - 2010/1/1. N2 - Kidney transplantation is the best treatment for patients with terminal kidney insufficiency, but due to a shortage of donor kidneys many people are deprived from this optimal care. Organ donation after a cardiac arrest can make the number of kidney transplantations rise and shorten or even eliminate the waiting list for kidney transplantations. However, because these donor kidneys are damaged by ischemia in the period between the cardiac arrest and organ preservation, there is a reticence to accept these donor kidneys. For this reason this dissertation closely studies the entire transplantation process from donor to receiver to find clinically usable methods that can prevent this primary non-function of donor kidneys after a cardiac arrest. ...
Kidney transplantation is worldwide considered the best replacement therapy in patients with end-stage renal disease. However, although impressive improvements in surgical techniques and in the management of immunosuppression, long-term results have not significantly changed over the last decades. The purpose of this book is not to be a comprehensive review on kidney transplantation, but it would overview the recent acquisitions in the field of kidney transplantation, by offering to clinicians the future directions and the possible fields of research to improve the long term outcome. The book is divided into 27 chapters. The first part of the book is devoted to the basic principles of immunity and organ transplantation and the clinical evaluation of potential recipient. Moreover, in this section are discussed the most recent strategies to increase the donor pool trying to offer a kidney transplantation to a growing number of patients. The second part of the book is devoted to the ...
The Banff Classification is a schema for nomenclature and classification of renal allograft pathology, established in 1991 by Kim Solez and Lorraine C. Racusen in Banff, Canada. The initiative was inspired by the then recent development of a consensus grading system for diagnosis of rejection in cardiac allografts led by Dr Margaret Billingham, a key participant at the first Banff meeting. Prior the Banff Classification there was no standardized, international classification for renal allograft biopsies, which resulted in considerable heterogeneity among pathologists in characterization of renal allograft biopsies. The first Banff schema was published in 1993, and has since undergone updates at regular intervals. The classification is expanded and updated every two years in meetings organized by the Banff Foundation for Allograft Pathology. An evaluation of the Banff Classification in March 2000 confirmed significant association between the revised Banff 97 classification and graft outcome. ...
Background: Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients. Methods: During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction [Med Arch 2017; 71(6.000): 408-411]. Keywords: End-stage renal disease, Echocardiography, Kidney transplantation, Cardiovascular disease. >>Full text PDF >>Abstract >>(10.5455/medarh.2017.71.408-411). ...
Requiring a formal patient education class may help reduce disparities in kidney failure patients access to kidney transplantation.. Being educated about your health and your treatment options is a good thing. According to a new study, kidney failure patients who take part in an education program are more likely to get evaluated for a kidney transplant. The study appears in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that requiring a formal patient education class may help reduce inequities in kidney failure patients access to kidney transplantation.. Kidney transplantation is the preferred treatment for kidney failure. Among kidney failure patients, blacks are less likely to receive kidney transplants than whites for reasons that are unclear. Unfortunately, few published studies have looked at interventions that might reduce such racial disparities in access to kidney transplantation.. In an attempt to educate patients about the ...
OBJECTIVE Renal transplantation with a well-functioning graft leads to a rapid restoration of endocrine and sexual functions. The aim of this study was to examine our experience with pregnancies among renal transplant patients, particularly with regard to their impact on graft function. PATIENTS AND METHODS We analyzed 10 pregnancies in 7 renal transplant recipients for long-term graft outcomes in terms of clinical and biological data. RESULTS The mean patient age was 28.5 +/- 4 years. They all received a living donor kidney. The time between transplantation and the onset of pregnancy was 33.4 +/- 23.2 months. Regarding the immunosuppressive therapy, all patients received steroids and cyclosporine; 4 patients received in addition azathioprine and 2 received mycophenolate mofetil that was changed at 1 month before conception to azathioprine. There was no significant difference between the serum creatinine before and during pregnancy. We did not observe any acute rejection episode. Pregnancy
Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals.. Although avoiding HLA [human leukocyte antigen; cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term graft survival, it has raised concerns about disadvantaging minority groups, particularly black patients, and pediatric patients, who have severe growth retardation and other problems when dialysis is prolonged before transplantation, the authors write as background information in the article. Currently, only HLA-DR matching is considered in the United Network for Organ Sharing (UNOS) organ allocation system.. To examine the relationship between HLA-DR mismatching and rejection, graft survival and ...
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Purpose: We have previously shown that transplant of kidneys from donor mice latently infected with murine cytomegalovirus (CMV) into naïve recipients treated with clinically relevant immunosuppression results in CMV reactivation and systemic dissemination. Our study is to determine the cellular and molecular mechanisms underlying CMV dissemination following kidney transplantation in immunocompromised recipients by blocking inflammatory mediators associated with transplant injury.. *Methods: Kidneys from BALB/c mice latently infected with Smith murine CMV were transplanted to binephrectomized naïve immunodeficient NSG mice deficient of T cells, B cells and NK cell function. Recipients were treated with various extracellular mediator blockers, including anti-IL-1β, anti-IL-6 receptor, anti-IL-18 receptor, anti-CD40L, anti-TNFα, or a cocktail mixed with the above antibodies. At endpoints, kidney grafts, spleens, salivary glands and lungs were collected for CMV immediate early (IE) gene copy ...
A kidney transplant is a life-changing and life-saving procedure. Yet, a new study conducted by Mayo Clinic and the University of Michigan shows that only one-third of patients who ultimately receive a living donor kidney transplant receive it pre-emptively (i.e., before starting dialysis). Less than two-thirds receive a transplant either pre-emptively or within a year of starting dialysis.. Existing research suggests that less time spent on dialysis before transplant can improve patient outcomes and survival after transplant. However, this new research shows there has been no increase in the utilization of what is known as timely living donor kidney transplants, which includes pre-emptive and early transplants, since 2006. The study Under-utilization of timely kidney transplants in those with living donors, was published recently in the American Journal of Transplantation.. Read more. ...
TY - JOUR. T1 - Cancer and mTOR inhibitors in kidney transplantation recipients. AU - Kao, Chih Chin. AU - Liu, Jia Sin. AU - Chang, Yu Kang. AU - Lin, Ming Huang. AU - Lin, Yen Chung. AU - Chen, Hsi Hsien. AU - Chang, Wei Chiao. AU - Hsu, Chih Cheng. AU - Wu, Mai Szu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background: Previous studies show that mTOR inhibitors decrease the risk of cancer development after kidney transplantation. However, the effect of cumulative doses of mTOR inhibitors on cancer after kidney transplantation is not well known. Methods: In the current study, patients were registered into a national database in Taiwan. Between year 2000 and 2013, 4,563 patients received kidney transplantation. They were divided into two groups, according to mTOR inhibitors usage. The cumulative dose of mTOR inhibitors was recorded. Patients were followed-up until de novo cancer development, death, or the end of 2014. Results: Patients were divided into two groups: mTOR inhibitors users (study group, ...
Purpose: To assess high hospital inpatient [IP] admissions and emergency department [ED] utilization within a 9-month period after kidney transplantation in order to identify potential mutable factors for reducing post-transplant health care utilization.. *Methods: This was a 9-year retrospective study in adult kidney transplant recipients from 01/2007-12/2015. Patients with previous transplant, or graft loss or death within 3 months post-transplantation, were excluded. Comprehensive resource utilization data were retrieved from state All-Payer Public Use data files. Patients with ≥2 IP admissions or standalone ED visits within 4-12 months post-transplantation were classified as high IP or ED utilizers. Multivariable logistic regression models were used for examining associations of predictors with high IP or ED utilization.. *Results: Of 1,280 kidney recipients, 209 (16.3%) and 183 (14.3%) were categorized as IP and ED high utilizers; respectively. Factors significantly associated (Figure 1) ...
TY - JOUR. T1 - Severe neurologic toxicity induced by cyclosporine A in three renal transplant patients. AU - Palmer, B. F.. AU - Toto, R. D.. PY - 1991. Y1 - 1991. N2 - Cyclosporine A (CyA) is a potent immunosuppressive agent that is used in organ transplantation and in a variety of immunological diseases. It has a variety of adverse side effects, some of which can be serious and even life-threatening. CyA-associated neurotoxicity is generally mild, consisting of fine tremor. However, more complex neurologic abnormalities, including motor spinal cord and cerebellar syndromes, have rarely been described in bone marrow and liver transplant patients. Renal transplant patients have been spared from such CyA-induced toxicity. In this report, three renal transplant patients are described who developed complex and severe neurologic toxicity in the setting of therapeutic blood levels of CyA, which was completely reversible on discontinuation of the drug. No patient had a prior history of neurological ...
TY - JOUR. T1 - Glomerular filtration rate in children following renal transplantation. AU - Seikaly, Mouin G.. AU - Browne, Richard. AU - Simonds, Nancy. AU - Atkins, Carolyn. AU - Alexander, Steven R.. PY - 1998/8/1. Y1 - 1998/8/1. N2 - Most studies evaluating renal function post-renal transplantation in children have used serum creatinine (SCr) or estimates of its clearance (CSCH). When renal function is impaired both SCr and the CSCH overestimate glomerular filtration rate (GFR), especially during cyclosporine therapy. This study measured GFR in 64 children (age range: 4-19 years) with stable renal function who received renal allografts at the Childrens Medical Center of Dallas, 31 from live related donors (LRD) and 33 from cadaveric donors (CAD). 125I- iothalamate clearance (CIO) was used as the reference standard for measuring GFR. Data from 100 CIO studies, were analyzed and results reported as mean ± S.E.M. CIO performed during the first year after renal transplantation in 23 children ...
View Poster. INTRODUCTION. Marginal kidneys have gained progressive acceptance with the use of extended criteria donor (ECD) kidneys, however there still remains high discard rates of these allografts. Increasing the donor pool can be accomplished through allocation for dual kidney transplantation (DKT) which has shown comparable outcomes to those from single kidney transplantation (SKT). This study analyzed the outcomes of DKT compared to SKT from marginal kidneys.. METHODS. Electronic databases including MEDLINE, EMBASE, PubMed and Cochrane library were searched using Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Each paper included was reviewed in duplicate. Patient factors including mean age of donors and recipients, gender and length of follow up was analyzed. The outcome measures analyzed included the cold ischemia time, graft survival, patient survival, serum creatinine in follow up and delayed graft function (DGF) in DKT compared to SKT. RESULTS. 17 publications ...
TY - JOUR. T1 - Kidney allograft survival outcomes in combined intestinal-kidney transplant. T2 - An analysis of the UNOS/OPTN database 2000-2014. AU - Moinuddin, Irfan. AU - Yaqub, Muhammad Sohail. AU - Taber, Tim. AU - Mujtaba, Muhammad. AU - Sharfuddin, Asif. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background and objectives: Intestinal transplants carry a high morbidity/mortality. Kidney allograft outcomes after combined intestinal (IT) with kidney transplant (CIKT) remain largely uninvestigated. Materials and methods: The UNOS STAR database was queried to identify all such combined organ transplants from 2000 to 2015. Results: Out of a total 2215 (51.4% peds vs 48.6% adults) intestinal transplants, 111 (5.0%) CIKT were identified (32.4% peds vs 67.6% adults). Over the study period of CIKT, a total of 45.9% of these cases died with a functioning kidney graft. DGF rate was 9.0%. The 1-year reported kidney acute rejection rate was 6.3%. For the entire CIKT population over the entire study era, the ...
EBV viremia occurs frequently after transplantation and can be related to post-transplant lymphoproliferative disorders (PTLD). However, the consequences of the majority of viremia are unclear. Barnoulid et al. followed EBV viral loads in 383 kidney transplant patients during the first year post-transplant. 40% of patients had at least one detected viremia; viremia was more common in EBV mismatched patients and those that received ATG. While these risk factors for EBV are well known, the authors also found that EBV infection was associated with opportunistic infection and graft loss. This study adds to our knowledge on EBV although further work is necessary to determine what to do with patients who had chronic low level viremia.. ...
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Definition of kidney transplantation in the dictionary. Meaning of kidney transplantation. What does kidney transplantation mean? Information and translations of kidney transplantation in the most comprehensive dictionary definitions resource on the web.
UAB has become a national leader in kidney transplantation since performing our programs first kidney transplant in 1968. Currently, the UAB Kidney Transplant Program is one of the largest kidney transplant centers in the nation, performing almost 300 transplants each year. Our reputation for excellence is based on our highly skilled transplant doctors, multidisciplinary team of specialists, dedication to patient care and education, and exceptionally high patient survival rates. Moreover, our patients benefit from our long history of experience and achievement in kidney transplantation. Since 1987, UAB has performed more living donor kidney transplants than any other kidney program in the United States, according to the United Network for Organ Sharing.. In 2006, UAB became the first transplant center in the Southeast to pursue paired-kidney exchange, a special type of living-donor arrangement. Blood-type and tissue incompatibility can be barriers to a successful donor-recipient match. However, ...
Ethical issues in kidney transplantation – reflections from Nigeria Joseph Olusesan Fadare1, Babatunde L Salako21Department of Medicine, Kogi State Specialist Hospital, Lokoja; 2Department of Medicine, University of Ibadan, Ibadan, NigeriaAbstract: Organ transplantation has become a life-saving procedure for many disease conditions hitherto considered incurable. Kidney transplantation, now the treatment of choice for end-stage renal disease, is the commonest solid organ transplantation carried out in the world at the moment and it is the only solid organ transplantation done in Nigeria. This procedure, in addition to prolonging lives, also provides better quality of life and is evaluated as cost-effective, because it makes more resources available to other sectors of the economy. Organ transplantation in general and kidney transplantation in particular are fraught with ethical issues and dilemmas worldwide. Some of the ethical issues arising in the setting of developing countries like Nigeria may
First of all, I apologize that the topic of the seminar has been announced to be the introduction of kidney transplantation at Rigshospitalet. During the past months, my focus has changed, and the material that I would like to discuss on Tuesday is the first and incomplete draft for an article on the history of organisation of kidney transplantation in Denmark from the mid-1960s onwards, thus a much wider topic. My purpose in the text is to examine different perspectives on how this organisation changed, primarily with a focus on the early period from ca. 1965 to 1980.. I plan to examine three such perspectives. The following text includes only the first one, and I have not yet written the remaining two, but I will present them all very briefly here. First, I look at how clinical changes in the transplantation of organs, mainly extended possibilities for the use of kidneys from dead donors, justified changes to the organisation of kidney transplantation in Denmark around 1970. The second ...
Background: Available data suggests that cyclosporin and tacrolimus differ in respect of nephrotoxicity and long term graft function in kidney transplantation. The aim of this study was to evaluate the impact of converting stable kidney allograft recipients from CyA-Me to TAC on renal function and cardiovascular risk profile. Material/Methods: 31 patients with stable renal function (Scr <3.0 mg/dl) were successfully switched from CyA-Me to TAC and followed up for 24 months. Majority (77.4%) had suspicion of CyA nephrotoxicity. Renal function was measured as serum creatinine (Scr) and calculated GFR. Office blood pressure and lipid profiles were evaluated. Results: 29 patients finished the 24 month observation period. 1 and 2 year patients survival was 100%; grafts survival was 93.5% and 91% respectively. No new cases of diabetes mellitus were identified. Mean SCr fell from 2.28±0.4 to 1.95±0.4 mg/dl (P<.02) and calculated GFR increased from 49.1±15 to 55.2±16 mL/min (P<.05). Total
Introduction: Direct-acting antivirals (DAAs) are widely used in the treatment of hepatitis C virus (HCV) infection in renal transplant recipients. Aim: The aim was to study the efficacy and safety of these drugs in our renal transplant recipients. Study Design, Subjects, and Methods: A retrospective observational study was performed among the renal transplant recipients , 18 years of age who were treated with DAA for HCV infection. The viral genotype, DAA regimen, the viral load at various time intervals, FibroScan score at the start and at the end of therapy, the changes in graft function (estimated glomerular filtration rate) and in the dosage of calcineurin inhibitors during therapy, and side effects if any during therapy were documented from history and transplant records. The viral remission rates and the safety of DAA were analyzed. Statistical analysis was done with Medcalc statistical software version Results: Thirty-three recipients were included in the study. The DAA ...
The January 2018 issue of the Journal of the American Medical Association features the article Association of Race and Ethnicity with Live Donor Kidney Transplantation in the United States From 1995 to 2014 authored by Tanjala S. Purnell and colleagues including Lisa Cooper, Deidra Crews and Ebony Boulware from the DOM. The study aims to estimate changes over time in racial/ethnic disparities in live donor kidney transplantation (LDKT) in the U.S. utilizing data from the Scientific Registry of Transplant Recipients between January 1995 to December 2014, with follow-up thorough December 2016. The articles notes that their findings exist amidst numerous interventions to address racial/ethnic disparities in LDKT including addressing barriers to knowledge, cultural concerns, attitudes, beliefs, behavior and policies to address economic barriers.. Of the over 450,000 adult kidney transplant candidates whose data was analyzed between 1995 and 2014, 13.1 percent received LDKT. The major findings from ...
TY - JOUR. T1 - Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. AU - Shapiro, Ron. AU - Nalesnik, Michael. AU - McCauley, Jerry. AU - Fedorek, Sheila. AU - Jordan, Mark L.. AU - Scantlebury, Velma P.. AU - Jain, Ashok. AU - Vivas, Carlos. AU - Ellis, Demetrius. AU - Lombardozzi-Lane, Susanne. AU - Randhawa, Parmjeet. AU - Johnston, James. AU - Hakala, Thomas R.. AU - Simmons, Richard L.. AU - Fung, John J.. AU - Starzl, Thomas E.. PY - 1999/12/27. Y1 - 1999/12/27. N2 - Between March 27, 1989 and December 31, 1997, 1316 kidney transplantations alone were performed under tacrolimus-based immunosuppression at our center. Posttransplant lymphoproliferative disorders (PTLD) developed in 25 (1.9%) cases; the incidence in adults was 1.2% (15/1217), whereas in pediatric patients it was 10.1% (10/99; P,.0001). PTLD was diagnosed 21.0±22.5 months after transplantation, 25.0±24.7 months in adults and 14.4±18.2 ...
Live Donor Kidney Transplantation: Updates in Paired Kidney Exchange Miguel Tan, MD, FRCSC Surgical Director, Kidney & Pancreas Transplantation Piedmont Transplant Institute Outline 1. 2. 3. Current statistics for kidney transplantation in the United States Living donor outcomes Paired exchange, impact, logistics and challenges Patients on the waiting list on December 31 of the year (active listings only) Organ supply continues to be a problem in kidney transplantation Almost 100 000 patients on waiting list Average waiting time to transplant 4- 5 years 4% of potential recipients die while waiting on list annually Transplants performed during the year (adult & pediatric combined) Deceased kidney donation rates Organ discard rate for organs recovered for transplantation Possible reasons for lack of growth of supply include -lack of education on donation options ie. living donation, paired exchange, desensitization -Increasing rate of morbid obesity and diabetes resulting poorer quality of organs ...
TY - JOUR. T1 - There are no differences in pretransplant characteristics of individuals receiving simultaneous pancreas-kidney transplant and individuals with type 1 diabetes mellitus receiving living-related kidney transplant. AU - Donigan, L.. AU - Stevens, R. B.. AU - Wrenshall, L.. AU - Larsen, J.. PY - 2004/5. Y1 - 2004/5. N2 - Abstract Simultaneous pancreas-kidney transplantation (SPK) recipients have longer survival compared to type 1 diabetes mellitus (DM1) cadaveric kidney recipients. However, DM1 living-related kidney transplant (KTX-LR) recipients have the same mortality as SPK recipients. It is unknown whether cardiovascular (CVD) risk factors pretransplant are similar between the two groups, SPK and DM1 KTX-LR. We analyzed pretransplant characteristics of SPK recipients (n = 39) and DM1 KTX-LR/living unrelated (LUR) recipients (KTX-LR/LUR, n = 20). In individuals who had multiple transplants, only pretransplant data from the first transplant was used. As all characteristics of ...
Living donor kidney transplantation , Living donor kidney transplantation , کتابخانه الکترونیک و دیجیتال - آذرسا
The purpose of this review was to investigate this in more detail-in particular the choice between a simultaneous pancreas-kidney transplantation and
Laparoscopic living donor kidney transplantation. Laparoscopic nephrectomy for kidney transplant has been established as a mainstream procedure both in Europe and the US because it allows donors to resume their daily activities very quickly.. In 2015 we performed the first laparoscopic living donor kidney transplant in a male patient following laparotomy. This 68-year-old patient had previously undergone surgery due to a car accident. Two 5mm trocars and one 10mm trocar were placed on the left midclavicular line, from the costal arch towards the anterior superior iliac spine and, a 10 mm trocar has been placed in the suprapubic area, which was replaced by a gelport for transplant removal.. Surgery lasted three hours. Warm ischemia time was three minutes.. The graft was immediately placed and the recipient had immediate diuresis with beginning of the renal function.. The postoperative course of the donor was unhindered and he was discharged from hospital on the fourth postoperative day.. The ...
TY - JOUR. T1 - A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation. AU - Bailey, Pippa. AU - Tomson, Charles. AU - MacNeill, Stephanie. AU - Marsden, Ann. AU - Cooke, Rhian. AU - Cook, Dominique. AU - Cooke, Rhian. AU - Biggins, Fiona. AU - OSullivan, Jim. AU - Ben-Shlomo, Yoav. PY - 2017/11. Y1 - 2017/11. N2 - This multicentre prospective potential living kidney donor cohort study investigated which sociodemographic and other factors predict progression to living kidney donation or donor withdrawal, as little is known on this topic. Data were collected on individuals undergoing living donor assessment at 7 UK hospitals from 01/08/14 to 31/1/16. Multivariable logistic regression was used to explore the relationships between donor and recipient characteristics and likelihood of kidney donation. 805 individuals presented for directed donation to 498 intended recipients. 112 intended recipients received a transplant from a ...
We are a leading center for living donor kidney transplant and incompatible blood type kidney transplant in adult and pediatric kidney transplant patients.
Live donor kidney transplantation has become a widely sought treatment by patients with end-stage renal failure. As the outcome for the genetically and emotionally related live donor transplants is the same, this review considers live kidney transplantation from the broad scope of current international practice. Unrelated live donor transplantation can now be performed for incompatible donor recipient pairs via a simultaneous paired kidney donation. However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. At a recent World Health Organization (WHO) conference of Middle East transplant professionals a statement of unequivocal opposition to commercialism was drafted. In the United States, the Institute of Medicine has recently published a significant report that affirms the legal prohibition of organ sales. These documents are in ...
TY - JOUR. T1 - Urine proteomic profiling for biomarkers of acute renal transplant rejection.. AU - Liang, Shu Ling. AU - Clarke, William. PY - 2010. Y1 - 2010. N2 - Acute allograft rejection is a serious impediment to long-term success in renal transplantation. Early detection of rejection is crucial for treatment of rejection, and can help avoid long-term effects such as chronic rejection or loss of the transplanted organ. The current diagnostic paradigm is a combination of clinical presentation, biochemical measurements (serum creatinine), and needle biopsy. There are significant efforts underway to find alternate biomarkers for early detection of acute rejection, including protein profiling of urine by mass spectrometry. One approach for protein profiling is to use affinity mass spectrometry - we describe a method for this using ProteinChips and SELDI-TOF mass spectrometry.. AB - Acute allograft rejection is a serious impediment to long-term success in renal transplantation. Early detection ...
The development of the meeting and workgroups, rationale for the topics, process of creating consensus, and top recommendations are outlined in more detail in an overview meeting report (3). Recommendations included strategies to educate patients with CKD and ESRD, potential living donors, and the public; efficiencies in processes; policy initiatives; and a research agenda. An important and recurring theme was the importance of coordination and communication between providers throughout the continuum of disease to most effectively reach patients and their support systems. This moving points edition will address consensus conference recommendations for a collaborative approach to care, education, and access to improve overall practice in LDKT and LKD.. Five articles address how transplant centers and community nephrology care teams can partner for improved practices. In the first article, Living Donor Kidney Transplantation: Improving Education Outside of Transplant Centers about Live Donor ...
Slow graft function after pediatric renal transplantation from volunteer live donors , Slow graft function after pediatric renal transplantation from volunteer live donors , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
TY - JOUR. T1 - Genomics of chronic allograft injury. AU - Akalin, Enver. AU - OConnell, Philip J.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2010/12. Y1 - 2010/12. N2 - Chronic allograft injury (CAI) is common after kidney transplantation in which immunological (e.g., acute and chronic cellular and antibody-mediated rejection) and nonimmunological factors (e.g., donor-related factors, ischemia-reperfusion injury, polyoma virus, hypertension, and calcineurin inhibitor nephrotoxicity) have a role. Despite the new Banff pathological classification, histopathological diagnosis is still far from being the gold standard to understand the exact mechanisms in the development of CAI, which may lead to appropriate treatment. Microarray is a powerful technology that detects thousands of genes simultaneously and might be an important tool in elucidating patterns for mechanism, diagnosis, prognosis, and treatment of complex, multifactorial diseases, such as CAI. In this ...
Mesenchymal stem cells (MSCs) are multi-potent non-hematopoietic progenitor cells possessing an immune-regulatory function, with suppression of proliferation of activated lymphocytes. In this study, adult living donor kidney transplantation (LDKT) recipients were given MSCs derived from the donor bone marrow to evaluate the safety and the feasibility of immunological changes related to the intra-osseous injection of MSC into the bone marrow. MSCs were derived from negative HLA cross-match donors. Donor bone marrow was harvested 5 weeks prior to KT. At the time of transplantation, 1 x 106 cell/kg of donor MSC was directly injected into the bone marrow of the recipients right iliac bone. Patients clinical outcomes, presence of mixed chimerism by short tandem repeat polymerase chain reaction, analysis of plasma FoxP3 mRNA and cytokine level, and mixed lymphocyte reaction (MLR) were performed. Seven patients enrolled in this study and received donor MSC injections simultaneously with LDKT. The median age
Compared with kidney transplantation alone, simultaneous pancreas-kidney (SPK) transplantation was associated with an almost twofold lower 10-year mortality among type 1 diabetics, in a retrospective study.. The study included all 2,796 patients with type 1 diabetes in the Netherlands who started renal replacement therapy or received a first kidney transplant between 1986 and 2016. As reported in Diabetes Care, of the 996 who received new kidneys, 42% received a deceased-donor kidney; 16%, a living-donor kidney; and 42%, an SPK transplant. Crude survival was highest in SPK recipients and lowest in recipients of a deceased-donor kidney. Median survival time was 7.3 years for deceased-donor kidney recipients; 10.5 years for living-donor kidney recipients; and 16.5 years for SPK recipients.. @media (min-width:500px){#social{padding:0 0 15px 67px}#link{display:none!important}#facebook{padding:0 29px 0 24px}}@media screen and ...
A living donor kidney transplant takes an organ from a living donor and transplants it to the recipient. Learn more about living kidney donation here.
A living donor kidney transplant takes an organ from a living donor and transplants it to the recipient. Learn more about living kidney donation here.
TY - JOUR. T1 - Psychiatric and psychological evaluation in living donor kidney transplantation: a single center experience. T2 - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. AU - Martinelli, V.. AU - Gregorini, M.. AU - Erasmi, F.. AU - Politi, P.. AU - De Pasquale, C.. AU - Pistorio, M.L.. AU - Abelli, M.. AU - Ticozzelli, E.. AU - Chiappedi, M.. AU - Pietrabissa, A.. AU - Rampino, T.. N1 - Export Date: 21 March 2021. PY - 2021. Y1 - 2021. M3 - Article. VL - 38. JO - G Ital Nefrol. JF - G Ital Nefrol. SN - 1724-5990. IS - 1. ER - ...
TY - JOUR. T1 - The Association of 25-Hydroxyvitamin D Levels with Late Cytomegalovirus Infection in Kidney Transplant Recipients. T2 - The Wisconsin Allograft Recipient Database. AU - Astor, Brad C.. AU - Djamali, Arjang. AU - Mandelbrot, Didier A.. AU - Parajuli, Sandesh. AU - Melamed, Michal L.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background. Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in kidney transplant recipients. Vitamin D has an integral role in proper immune function, and deficiency is common among kidney transplant recipients. It remains unclear whether 25-hydroxyvitamin D [25(OH)D] level is associated with CMV infection in kidney transplant recipients. Methods. We examined the relationship between 25(OH)D levels, measured at least 6 months posttransplant, and subsequent CMV infection in 1976 recipients free of prior CMV infection. Results. Of 1976 recipients, 251 (12.7%) were vitamin D deficient [25(OH)D ,20 ng/mL] and 548 (27.7%) were insufficient ...
R SHINGDE1, V CALISA1, JC CRAIG2, JR CHAPMAN3, AC WEBSTER3, H. PLEASS3, P OCONNEL3L, R ALLEN3, P ROBERTSON3, L YUEN3, K KABLE3, B NANKIVELL3, N ROGERS3, G. WONG2,3. 1Centre for Kidney Research, The Childrens Hospital at Westmead, Westmead; 2Sydney School of Public Health, University of Sydney, Sydney; 3Centre for Transplant and Renal Research, Westmead Hospital, Westmead. Aim: To compare the absolute and relative health gains and costs of simultaneous pancreas kidney (SPK) with deceased donor kidney alone transplantation and dialysis in patients with type 1 diabetes mellitus (DM) and end-stage kidney disease (ESKD).. Background: The long-term costs and health benefits of SPK transplantation, compared to dialysis and deceased donor kidney alone transplant are unclear in this setting.. Methods: Two deterministic Markov models comparing patient survival in patients with Type I DM and ESKD who were either waitlisted on dialysis, received a SPK or deceased donor kidney alone transplantation were ...
Ethics of Living Donor Kidney Transplantation Interviewer: Quentin Cooper Interviewees: Mr Andrew Ready, Trustee and Lead Surgeon of TLC, Dr Shazia Shabir, Consultant Nephrologist at University Hospitals Birmingham and TLC volunteer, and Dr Dwomoa Adu, Consultant Nephrologist at Korle Bu Hospital, Accra, Ghana, and TLC Trustee Welcome to this TLC podcast in which science journalist,…
Understand more about why beliefs about organ donation within different communities may impact on decisions about living donor kidney transplantation amongst people from different ethnic backgrounds.. ...
TY - JOUR. T1 - Effects of dipeptidyl peptidase-4 inhibitors on hyperglycemia and blood cyclosporine levels in renal transplant patients with diabetes. T2 - A pilot study. AU - Bae, Jaehyun. AU - Lee, Min Jung. AU - Choe, Eun Yeong. AU - Jung, Chang Hee. AU - Wang, Hye Jin. AU - Kim, Myoung Soo. AU - Kim, Yu Seun. AU - Park, Joong Yeol. AU - Kang, Eun Seok. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Background: The use of dipeptidyl peptidase-4 (DPP-4) inhibitors is increasing among renal transplant patients with diabetes. However, the glucose-lowering efficacies of various DPP-4 inhibitors and their effects on blood cyclosporine levels have not been fully investigated. We compared the glucose-lowering efficacies of DPP 4 inhibitors and evaluate their effects on the blood levels of cyclosporine in renal transplant recipients with diabetes. Methods: Sixty-five renal allograft recipients who received treatment with DPP-4 inhibitors (vildagliptin, sitagliptin, or linagliptin) following kidney transplant ...
TY - JOUR. T1 - Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study. AU - Citterio, Franco. AU - Hirsch, H. H.. AU - Vincenti, F.. AU - Friman, S.. AU - Tuncer, M.. AU - Wiecek, A.. AU - Scheuermann, E. H.. AU - Klinger, M.. AU - Russ, G.. AU - Pescovitz, M. D.. AU - Prestele, H.. PY - 2013. Y1 - 2013. N2 - Polyomavirus BK (BKV)-associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. A total of 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). Risk factors were analyzed in 629 (92.2%) patients having at least 2 BKV measurements until month 12 posttransplant. Univariate analysis associated CsA-MPA with lower rates of viremia than Tac-MPA at month 6 (10.6% vs. 16.3%, p = 0.048) and 12 ...
TY - JOUR. T1 - The power of renal function estimation equations for predicting long-term kidney graft survival a retrospective comparison of the chronic kidney disease epidemiology collaboration and the modification of diet in renal disease study equations. AU - Choi, Hoon Young. AU - Joo, Dong Jin. AU - Song, Mi Kyung. AU - Kim, Myoung Soo. AU - Park, Hyeong Cheon. AU - Kim, Yu Seun. AU - Kim, Beom Seok. N1 - Publisher Copyright: © 2016 Wolters Kluwer Health, Inc. All rights reserved.. PY - 2016. Y1 - 2016. N2 - Evaluation of renal function using an accurate estimation equation is important for predicting long-term graft survival. We designed this retrospective cohort study to evaluate the predictive power of renal function estimation by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) study equations for graft survival. We reviewed data of 3290 adult kidney transplant recipients who underwent transplantation at a single ...
Critical evaluation of radiolabeled lymphocytes to detect acute renal transplant rejection in a large animal model. - Get your full text copy in PDF #4818
Background: Kidney transplant (Tx) patients present a reduced cardiovascular (CV) mortality in comparison to the dialysis population, but in comparison to the general population, it is still several-fold higher. Methods: We studied risk factors for CV disease in a group of 38 patients (50% males, median age 36 years) who underwent a living donor Tx at the baseline and after 3 ± 1 and 9 ± 2 months. Results: The prevalence of overweight increased from 26 to 54% after Tx (p | 0.001). The mean systolic blood pressure decreased significantly after the Tx (148 ± 27.6 vs. 126 ± 12.7 mm Hg). There was a significant increase in LDL (97 ± 30 vs. 114 ± 35) and hematocrit (33.8 ± 4.4 to 42 ± 5.7%) levels and a significant reduction in fibrinogen levels (394 ± 91 vs. 366 ± 100 mg/dl) after 9 months as compared to the baseline. Obesity and dislipidemia were significantly correlated with inflammation. Significant changes in left ventricle mass index (293 ± 116 vs. 241 ± 96) were observed after the Tx.
TY - JOUR. T1 - Venous thromboembolic complications after kidney and kidney-pancreas transplantation. T2 - A multivariate analysis. AU - Humar, A.. AU - Johnson, E. M.. AU - Gillingham, K. J.. AU - Sutherland, D. E.. AU - Payne, W. D.. AU - Dunn, D. L.. AU - Wrenshall, L. E.. AU - Najarian, J. S.. AU - Gruessner, R. W.. AU - Matas, A. J.. PY - 1998/1/27. Y1 - 1998/1/27. N2 - Background: We reviewed the incidence of and risk factors for venous thromboembolic complications in our population of kidney (KTx) and simultaneous kidney-pancreas transplant (SPK) recipients. methods: Information was collected retrospectively from a database on 1833 KTx and 276 SPK recipients who underwent transplant surgery between January 1985 and August 1995. Results. The incidence of deep venous thrombosis (DVT) was 6.2%(n = 132), with significantly higher rates after SPK (18.1%) vs. KTx (4.5%) (P,0.001). The number of DVT episodes was highest in the first month; 17.5% occurred during this tine. For KTx recipients, ...
TY - JOUR. T1 - Association of prevalent vascular disease with allograft failure and mortality in live-donor kidney transplant recipients - a retrospective cohort study. AU - Mainra, Rahul. AU - Wong, Germaine. AU - Pilmore, Helen. AU - Lim, Wai H.. PY - 2019/6/26. Y1 - 2019/6/26. N2 - Limited data exist regarding the impact of prevalent vascular disease after live-donor kidney transplantation. We aimed to determine the associations between the number of prevalent vascular diseases, allograft, and patient outcomes following live-donor transplantation. This cohort study used data from the Australia and New Zealand Dialysis and Transplant Registry. Rates between recipients of live-donor kidney transplants ± prevalent vascular disease prior to transplantation were calculated. The associations between vascular disease, allograft failure, and all-cause mortality were assessed using Cox regression modeling. Kaplan-Meier proportions were used to calculate all-cause mortality and death with a function ...
TY - JOUR. T1 - Sero-molecular evaluation of human cytomegalovirus disease in renal transplant rejection.. AU - Kishore, Janak. AU - Mukhopadhyay, Chiranjoy. AU - Savitri, AU - Ayyagari, Archana. AU - Sharma, Rakesh Kumar. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Cytomegalovirus (CMV) is the most common viral pathogen in renal transplant recipients resulting in graft rejection. The prevalence of CMV disease and renal graft rejection is not well studied in India. Sequential specimens from 32 renal allograft recipients were examined by using CMV IgM specific mu capture ELISA and DNA by PCR. Twelve of the 32 patients were CMV IgM positive and out of 12 patients, 9 had rejection and 4 experienced CMV disease. CMV IgM specific mu capture ELISA helped in diagnosis of CMV disease, though it is less sensitive in detection of rejection. PCR itself was proved not sensitive enough in detecting either CMV disease or rejection. At present, optimal laboratory detection of CMV infection in these patients can be ...
TY - JOUR. T1 - Use of Ultrasound and Cystoscopically Guided Pancreatic Allograft Biopsies and Transabdominal Renal Allograft Biopsies. T2 - Safety and Efficacy in Kidney-Pancreas Transplant Recipients. AU - Kuhr, Christian S.. AU - Davis, Connie L.. AU - Barr, Darlene. AU - McVicar, John. AU - Perkins, James D.. AU - Bachi, Carlos E.. AU - Alpers, Charles E.. AU - Marsh, Christopher L.. PY - 1995. Y1 - 1995. N2 - The use of allograft biopsies to guide treatment after solid organ transplantation is a valuable tool in the detection and treatment of rejection. Prior development and use of the cystoscopically guided pancreatic allograft biopsy have allowed for more accurate and timely diagnosis of pancreatic allograft dysfunction, possibly contributing to our 1-year pancreas graft, renal allograft and patient survival rates of 87.1%, 88.5% and 96.8%, respectively. We reviewed our experience, examining efficacy and complication rates of pancreas and kidney biopsies in 31 cadaveric pancreas or ...
Pre-transplant nephrectomy is performed to reduce risks to graft and recipient. The aims of this study were to evaluate (1) indications, surgical approach, and morbidity of native nephrectomy and (2) the effects of kidney removal on clinical and biological parameters. This study was designed as a single-center retrospective cohort study in which 49 consecutive patients with uni- or bilateral native nephrectomies were identified from a total of 126 consecutive graft recipients in our pediatric kidney transplantation database between 1992 and 2011. Demographic, clinical, and laboratory details were extracted from charts and electronic records, including operation reports and pre- and post-operative clinic notes. Of the 49 nephrectomized patients, 47% had anomalies of the kidneys and urinary tract, 22% had cystinosis, 12% had focal segmental glomerulosclerosis, and 6% had congenital nephrotic syndrome. Nephrectomy decisions were based on clinical judgment, taking physiological and psychosocial aspects into
TY - JOUR. T1 - Isolated heart and liver transplant recipients are at low risk for polymavirus BKV nephropathy. AU - Puliyanda, Dechu P.. AU - Amet, Nurmamet. AU - Dhawan, Archana. AU - Hilo, Lara. AU - Radha, Raju K.. AU - Bunnapradist, Suphamai. AU - Czer, Lawrence. AU - Martin, Paul. AU - Jordan, Stanley. AU - Toyoda, Mieko. PY - 2006/5/1. Y1 - 2006/5/1. N2 - Background: BKV infection and nephropathy is a significant cause of allograft dysfunction in kidney transplantation. BKV viremia, rather than viruria, corresponds to BKV nephropathy. The prevalence of BKV viremia in non-renal solid organ transplants has not been systematically evaluated. Methods: We determined prevalence of BKV viremia in kidney, combined kidney-heart, kidney-liver, kidney-pancreas, kidney-heart-liver, and heart and liver transplant recipients using BKV-PCR. Results: Seven out of 173 (4%) kidney transplant recipients had BKV viremia, with BKV , 2 × 105 copies/mL in 6/7 and 1.9 × 103 in the remaining one patient. BKV ...
Chronic renal transplant rejection is a form of renal transplant rejection. It usually later following transplantation. Pathology Chronic rejection is defined as a gradual deterioration in graft function beginning at least 3 months after transp...
The Lorma Kidney Transplant Center provides personalized, holistic and best possible care to kidney transplant patients and their family. Our team is dedicated to make the entire kidney transplant process more convenient and less stressful for the patient. It has a multidisciplinary team composed of our best health care professionals who utilize evidence based practices and state-of-the-art diagnostic and surgical equipment.. Kidney Transplant: The best option for end-stage. Most often, kidney transplantation is the best treatment option for patients with chronic and end-stage renal disease. A kidney transplant is an operation that places a healthy kidney in the body. The transplanted kidney takes over the work of the two kidneys that failed and dialysis is no longer needed. Often,the new kidney will start making urine as soon as blood starts flowing through it. A successful kidney transplant affords a new beginning for ESRD patients because it offers enhanced quality and duration of ...
The ICAVL guidelines for transplant renal artery duplex ultrasound are similar to those for native arteries, with variations that include the need to examine the peri-transplant region with gray scale images, the arterial anastomosis with spectral Doppler waveforms and velocity measurements and the venous anastomosis with spectral Doppler waveforms. It should be noted that as external iliac artery stenosis can result in impaired blood flow to the transplanted kidney, this artery should also be interrogated as part of a complete examination.. Furthermore, it should be noted that transplant renal arteries have two characteristics that may cause elevated peak systolic velocity without stenosis. First, an end to side anastomosis may cause a local tortuosity and second, a transplant kidney tends to undergo hypertrophy and may be supplied by a higher than normal blood volume. Also, there is large normal variability of peak systolic velocity in transplant renal arteries.. Published peak systolic ...
BACKGROUND: Campath 1H is a depleting, humanized anti-CD52 monoclonal antibody that has now been used in 31 renal allograft recipients. The results have been very encouraging and are presented herein. METHODS: Campath 1H was administered, intravenously, in a dose of 20 mg, on day 0 and day 1 after renal transplant. Low-dose cyclosporine (Neoral) was then initiated at 72 hr after transplant. These patients were maintained on low-dose monotherapy with cyclosporine. RESULTS: At present, the mean follow-up is 21 months (range: 15-28 months). All but one patient are alive and 29 have intact functioning grafts. There have been six separate episodes of steroid-responsive rejection. One patient has had a recurrence of her original disease. Two patients have suffered from opportunistic infections, which responded to therapy. One patient has died secondary to ischemic cardiac failure. CONCLUSIONS: Campath 1H has resulted in acceptable outcomes in this group of renal allograft recipients. This novel therapy is of
Background: The prevalence of metabolic syndrome (MS) after renal transplantation has yet to be elucidated. In the present study, we investigated the prevalence of MS in Japanese renal transplant recipients.. Methods: A cross-sectional study was conducted to determine the prevalence of MS in 101 renal transplant recipients at Osaka City University Hospital. The prevalence of MS was determined using the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria (modified and original) and the International Diabetes Federation (IDF) criteria.. Results: Using the modified (Japanese) NCEP criteria, a total of 24 out of 101 patients (23.8%) had MS including 21 out of 64 male patients (32.8%) and three out of 37 female patients (8.1%). Using the modified (Asian) NCEP criteria, MS was diagnosed in 23 patients (22.8%); 19 male (29.7%) and four female (10.8%). Using the original NCEP criteria, MS was diagnosed in 15 patients (14.9%); 12 male (18.8%) and three female (8.1%). ...
PURPOSE: The development of a symptomatic lymphocele (SL) is a frequent postoperative surgical complication after kidney transplantation. It may lead to pain and discomfort and cause transplant malfunction or even secondary graft loss. A large cohort of renal recipients was investigated to identify the possible risk factors for SL. METHODS: All renal transplant patients of a single centre were retrospectively analysed for SL between January 2010 and December 2017. The SL group was compared to a control group from the same cohort. RESULTS: 45 out of 1003 transplanted patients developed an SL (incidence 4.5%), on average 50 days after kidney transplantation. SLs developed more in older patients, in those with a PD catheter and in ADKDP as primary diagnosis. Surgical predictors for SLs were venous anastomosis on the external iliac vein, concomitant PD catheter removal, perfusion defects, shorter operating time, splint , 7 days, double J stenting, discharge with drain, low initial drain production ...
Heres my already-submitted public comment to OPTN on their proposed policy for living kidney donor follow-up. The deadline for comment is December 23rd, so theres still time to compose and submit your own. The purpose of this missive is to respond to the proposed policy to establish minimum requirements for living kidney donor follow-up. Nearly 60 years after the first LKD transplant, there have been no randomized controlled trials to determine the testing required for the evaluation of living kidney donors(1). Transplant programs have little data to guide them in deciding which donors are unacceptable, or which characteristics are associated with kidney disease or poor psychosocial outcomes after donation(2) . Published studies are either single center, susceptible to selection bias and small sample sizes, or compare living donors the general public, an incorrect cohort(3) . Meanwhile, over the past 30 years, living kidney donors have gotten older, increased in pre-donation BMI, and decreased ...
Kidney transplantation. Kidney transplants are the treatment of choice for end-stage kidney disease, which is one of the ... Kidneys. Painless passage of blood or protein in the urine may often be the only presenting sign of kidney involvement. Acute ... electrolytes and kidney function (disturbed if the kidney is involved), liver enzymes, and complete blood count. ... Males tend to have more seizures, kidney disease, serositis (inflammation of tissues lining the lungs and heart), skin problems ...
"Kidney Transplantation: Past, Present, and Future. University of Michigan Medical Center/Stanford University. Retrieved 14 Dec ...
Saudi Journal of Kidney Diseases and Transplantation. 24 (5): 938-41. doi:10.4103/1319-2442.118087. PMID 24029258. Mercadante, ...
Saudi Journal of Kidney Diseases and Transplantation. 23 (2): 363-366. PMID 22382240.. ... of all cases of acute kidney failure in adults and more than 20% of cases of acute kidney failure during late pregnancy.[15][16 ... Renal cortical necrosis (RCN) is a rare cause of acute kidney failure. The condition is "usually caused by significantly ... While the only diagnostic "gold standard" mechanism of diagnosis en vivo is via kidney biopsy, the clinical conditions and ...
Keith Reemtsma . . . kidney transplantation . . . one of Reemtsma's patients lived for 9 months, returning to work as a ... Lung Transplantation: Principles and Practice, edited by Wickii T. Vigneswaran, Edward R. Garrity, Jr., John A. Odell, "Ch. 3 ... Heart Transplantation in Man: Developmental Studies and Report of a Case, JAMA (Journal of the American Medical Association), ... See also Lung Transplantation in same issue. Anesthesia for Transplant Surgery, Jayashree Sood, Vijay Vohra, New Delhi, London ...
... with end-stage kidney disease often require hemodialysis and eventually kidney transplantation to replace the failed kidney ... kidney stones or polycystic kidney disease.[28] Conformation kidney biopsy should only be performed if non-diabetic kidney ... Diabetic nephropathy(DN), also known as diabetic kidney disease,[4] is the chronic loss of kidney function occurring in those ... About half of insulin is metabolized and cleared by the kidneys. This means that as kidney function worsens in the setting of ...
The drug is used primarily in liver and kidney transplantations, although in some clinics it is used in heart, lung, and heart/ ... It is used in kidney transplantations. Other cytotoxic antibiotics are anthracyclines, mitomycin C, bleomycin, mithramycin. ... Pancreas-Kidney Transplantation: Drugs, a brief history of immunosuppressive drugs. Accessed on 21 August 2005. ... They are used in the prophylaxis of the acute organ rejection after bilateral kidney transplantation, both being similarly ...
"Calcineurin inhibitors in HLA-identical living related donor kidney transplantation". Nephrology, dialysis, transplantation : ... antibodies against human T cells which is used in the treatment of acute rejection in organ transplantation. Its use was first ... Transplantation Surgery. Springer Science & Business Media. p. 11. ISBN 9781447136897. Verghese, PS; Dunn, TB; Chinnakotla, S; ... "A comparison between ALG and bone marrow transplantation in treatment of severe aplastic anemia". Thymus. 10 (1-2): 147-58. ...
"Kidney Transplantation: A History". In Peter Morris (ed.). Kidney Transplantation - Principles and Practice E-Book. Stuart J. ... "The Anurias following Kidney Transplantation", Journal of Internal Medicine, Vol. 148, Issue 2, January/December 1954, pp. 91- ... Despite this, within six years, he produced more than 100 articles on kidney transplantations in dogs and achieved worldwide ... The post-war interest in kidney transplantation was paralleled by a growing knowledge that immunological mechanisms were ...
Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney, Nat Med. 2013 May ; 19(5): 646-651 by ... Regenerative capacity of the kidney has been recently explored. The basic functional and structural unit of the kidney is ... The regenerative capacity of the mammalian kidney is limited compared to that of lower vertebrates. In the mammalian kidney, ... Like other organs, the kidney is also known to regenerate completely in lower vertebrates such as fish. Some of the known fish ...
"Clinical case: Horseshoe kidney transplantation". Kenhub. Retrieved 2019-09-28. Lotti M. Anatomy in relation to left colectomy ... A horseshoe kidney, a common (1 in 500) anomaly of the kidneys, will be positioned below the IMA. The abdominal aorta and its ... Posterior abdominal wall, after removal of the peritoneum, showing kidneys, suprarenal capsules, and great vessels. Front of ... "CT findings of the main pathological conditions associated with horseshoe kidneys". The British Journal of Radiology. 88 (1045 ...
It is widely used before kidney transplantation to assess the vascularity of the kidney to be transplanted and with a test dose ... "Renal scintigraphy for post-transplant monitoring after kidney transplantation". Transplantation Reviews. 32 (2): 102-109. doi: ... If the kidney is getting blood, but there is an obstruction inferior to the kidney in the bladder or ureters, the radioisotope ... Kramer W, Baum RP, Scheuermann E, Hör G, Jonas D (1993). "[Follow-up after kidney transplantation. Sequential functional ...
"Ureteral stenosis after kidney transplantation". Transplant International. 12 (5): 334-340. doi:10.1007/s001470050236. ISSN ... A kidney stone can move from the kidney and become lodged inside the ureter, which can block the flow of urine, as well as ... The affected kidney could then develop hydronephrosis, should a part of the kidney become swollen due to blocked flow of urine ... These animals possess an adult kidney derived from the metanephros. The duct that connects the kidney to excrete urine in these ...
Naesens, M (2014). "The Histology of Kidney Transplant Failure: A Long-Term Follow-Up Study". Transplantation. 98 (4): 427-435 ... a b c ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young ... West, L. J. (2011). "ABO-incompatible hearts for infant transplantation". Current Opinion in Organ Transplantation. 16 (5): 548 ... Kidney transplantation is more successful, with similar long-term graft survival rates to ABOc transplants.[7] ...
... pancreas and pancreatic islet cell transplantation and one of two sites for kidney transplantation in Scotland.[7] In 2012 the ... "History of Kidney Transplantation". University of Edinburgh. Retrieved 10 February 2019.. ... In 1960, the first successful kidney transplant performed in the UK was at this hospital.[5] In 1964, the world's first ... 2000 - Scotland's first combined kidney and pancreas transplant [40]. *2008 - Scotland's first live donor liver transplant by ...
Fix M (1998). "HLA Matching, Antibodies, and You". Kidney Transplantation: Past, Present, and Future. University of Michigan ... This level of variation on MHC Class I is the primary cause of transplant rejection, as random transplantation between donor ...
"History of Kidney Transplantation in Edinburgh". EdREN. Royal Infirmary of Edinburgh. 2001. Archived from the original on 2009- ... October 30 - The first kidney transplantation in the United Kingdom is performed by a team led by English surgeon Michael ...
... his most important clinical accomplishments were in kidney transplantation. Most notably, he performed the first ever kidney ... "History of Kidney Transplantation in Edinburgh". Archived from the original on 6 February 2009. Retrieved 30 November 2008. " ... His work in these areas of transplantation biology led Woodruff to perform the first kidney transplant in the United Kingdom, ... The donor kidney was harvested by James Ross and transplanted by Woodruff. Both twins lived an additional six years before ...
"Lipopolysaccharide-binding protein as a new and reliable infection marker after kidney transplantation". Transpl. Int. 15 (4): ...
Manninen AH (2005). "High-protein diets are not hazardous for the healthy kidneys". Nephrology Dialysis Transplantation. 20 (3 ... It was once thought that a high-protein diet entails risk of kidney damage, but studies have shown that kidney problems only ... However, failure to properly hydrate can put an increased strain on the kidney's ability to function.[57][58] An adequate ... and repair nor consumed for energy is converted into urea mainly through the deamination process and is excreted by the kidneys ...
Sunil Shroff (1 July 2016). "Current trends in kidney transplantation in India". "Organ Donation: What Tamil Nadu Got Right". ... Data incomplete; includes only kidney, liver and heart donations; Source: NOTTO Organ transplantation in Tamil Nadu "Organ ... "Organ Transplantation in India". Retrieved 29 April 2020. "The Andhra Pradesh Transplantation of Human Organs Act, 1995" (PDF ... TRANSTAN Source Source Apex Kidney Foundation Gift Your Organ MOHAN Foundation Narmada Kidney Foundation Shatayu Source A large ...
Saudi Journal of Kidney Diseases and Transplantation. 23 (2): 343-345. ISSN 1319-2442. PMID 22382232. Whitworth, Judith A.; ... An ultrasound will be done to see if there is inflammation of the kidneys and to look for blockages.[citation needed] A kidney ... Nephrology Dialysis Transplantation. 24 (9): 2729-2734. doi:10.1093/ndt/gfp173. ISSN 0931-0509. PMID 19395731. "Kidney Disease ... Kidney Int Suppl. 2017;7:1-59". Kidney International Supplements. 7 (3): e1. December 2017. doi:10.1016/j.kisu.2017.10.001. ...
"Organ transplantation: A Sunni Islamic perspective". Saudi Journal of Kidney Diseases and Transplantation. 23 (4): 817-22. doi: ... This allowed for the immediate start of organ transplantation in Saudi Arabia. The IIFA later issued a fatwa on organ ... The International Islamic Fiqh Academy had a large hand in the allowance of organ transplantations. In 1986, the International ... transplantation that expanded the practice . In 1992, 1997, 2004, 2006, and 2018, the IIFA issued resolutions (fatwas) about ...
Once kidney failure has developed, patients usually do well on dialysis or with a kidney transplant. Transplantation can rarely ... Saudi Journal of Kidney Diseases and Transplantation. 17 (3): 320-5. PMID 16970251. Pescucci C, Mari F, Longo I, Vogiatzi P, ... To be helpful, kidney biopsies need to be taken before the disease is too advanced. Changes on conventional (light) microscopy ... Progressive loss of kidney function (reflected clinically by increases in serum creatinine or decreases in estimated glomerular ...
Hardinger KL, Brennan DC, Klein CL (July 2013). "Selection of induction therapy in kidney transplantation". Transplant ...
His other fields of research included shock treatment, organ procurement, open-heart surgery and kidney transplantation. ... Thomas, Beje (16 May 2018). "Kidney-Pancreas Transplantation: Overview, Periprocedural Care, Technique". Medscape. "The C. ... Gruessner, Rainer W. G.; Sutherland, David E. R. (2004). "4. History of Pancreas Transplantation". Transplantation of the ... On 17 December 1966, Lillehei assisted William Kelly transplant part of a pancreas and a whole kidney into a 28-year-old woman ...
RI is also commonly used to monitor kidney status, especially following kidney transplant. Following kidney transplantation, ...
"Laparoscopic Kidney Transplantation by George P. Abraham". YouTube video. Kairali TV. 18 July 2012. Retrieved 9 June 2016. v t ...
American Journal of Transplantation. September 2015, 15 (9): 2431-42. PMID 25943855. doi:10.1111/ajt.13288.. ... Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients. ... The role of peripheral T-cell deletion in transplantation tolerance. Philosophical Transactions of the Royal Society of London ... IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cellular Physiology and Biochemistry. 2016, 38 ...
It is also used as induction therapy in highly sensitized patients going for kidney transplantation. The use of rituximab has ... Rituximab is being used off-label in the management of kidney transplant recipients. This drug may have some utility in ...
... (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation. American Society for Blood and Marrow Transplantation. 2 (1): 3-14. PMID 9078349. ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ... a b Memorial Sloan-Kettering Cancer Center , Blood & Marrow Stem Cell Transplantation , The Graft-versus-Tumor Effect Archived ...
For example, gastroenterologists and nephrologists specialize respectively in diseases of the gut and the kidneys.[23] ... The anesthesiologist's role during surgery is to prevent derangement in the vital organs' (i.e. brain, heart, kidneys) ...
Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ... Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... dialysis or kidney transplantation) and plasma exchange. Kidney problems can have significant impact on quality and length of ...
Liver transplantation may be a valid option if no improvement occurs.[33] ... while the lung and kidneys may also be capable of storage.[20] ...
... "permanent kidney damage, sometimes resulting in kidney failure that has required kidney dialysis or kidney transplantation. In ...
The recipient of a hand transplant needs to take immunosuppressive drugs similar to other transplants such as kidneys or livers ... 2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The "donor" hand usually comes ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team,[14] performed a hand ...
In its terminal state, the kidneys and the heart are affected. FAP is characterized by the systemic deposition of amyloidogenic ... The disadvantage of liver transplantation is that approximately 10% of the subjects die from the procedure or complications ... Additional testing should be performed to identify involvement of the heart or kidneys.[6] ... FAP can be ameliorated by liver transplantation. ...
Narita M, Muder RR, Cacciarelli TV, Singh N (August 2008). "Protothecosis after liver transplantation". Liver Transpl. 14 (8), ... Bondarenko VI, Zadorozhnaia VI (March 1992). "[The role of enteroviruses in the etiology of diseases of the pancreas, kidneys ...
April 2000). "Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to- ... and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by ... "Liver transplantation for homozygous familial hypercholesterolaemia". Arch. Dis. Child. 73 (5): 456-8. doi:10.1136/adc.73.5. ... "Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous ...
Vanderbilt also offers an organ transplantation center. Vanderbilt's first kidney transplant was in 1962; since then there have ... been more than 3,000 kidneys transplanted at Vanderbilt. VUMC has also had more than 2000 liver transplants and 600 heart and ...
... or absent kidneys with resultant chronic kidney disease or kidney failure. Ear anomalies include extra openings in front of the ... "Nephrology Dialysis Transplantation. 17 (6): 1014-1018. doi:10.1093/ndt/17.6.1014. ISSN 0931-0509. PMID 12032190.. ... "Kidney International. 65 (2): 369-385. doi:10.1111/j.1523-1755.2004.00390.x. ISSN 0085-2538. PMID 14717907.. ... Branchio-oto-renal syndrome (BOR) , is an autosomal dominant genetic disorder involving the kidneys, ears, and neck. It often ...
Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ...
University Hospital ranked among top 50 hospitals in the U.S. in three specialties: Respiratory Disorders, Kidney Disease and ... Other noted programs include: cellular and structural biology, urology, nephrology, transplantation biology, aging and ...
TransplantationEdit. Main article: Kidney transplantation. Millions of people across the world suffer from kidney disease. Of ... the complete loss of kidney function. Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney ... Kidney disease usually causes a loss of kidney function to some degree and can result in kidney failure, ... Generally, the progression of kidney disease is from mild to serious. Some kidney diseases can cause kidney failure. ...
It is used in, for example, the organ transplantation of kidneys. This short article about medicine can be made longer. You can ...
For the development of liver transplantation, which has restored normal life to thousands of patients with end-stage liver ... Development of renal hemodialysis, which changed kidney failure from a fatal to a treatable disease, prolonging the useful ...
... a non-profit to raise awareness about organ donation and transplantation upon finding out his cousin was in need of a kidney ... with kidney transplant recipient Dillon Gonzalez and his family in attendance. The foundation was funded in part by admission ...
Retrograde ureteral, an intervention used to remove kidney stones. References[edit]. *^ El-Ghar MA, Osman Y, Elbaz E, Refiae H ...
OMIM entries on UMOD-Related Kidney Disease Includes: Familial Juvenile Hyperuricemic Nephropathy, Medullary Cystic Kidney ... Stamp L, Searle M, O'Donnell J, Chapman P (2005). "Gout in solid organ transplantation: a challenging clinical problem". Drugs ... A ketogenic diet impairs the ability of the kidney to excrete uric acid, due to competition for transport between uric acid and ... The gene SLC2A9 encodes a protein that helps to transport uric acid in the kidney. Several single nucleotide polymorphisms of ...
Hemolyzed hemoglobin is bound to a protein in plasma called haptoglobin, which is not excreted by the kidney.[48] ... The blood type needs to be determined to prepare for a blood transfusion or an organ transplantation. ... synthesised by the kidney. Just before and after leaving the bone marrow, the developing cells are known as reticulocytes; ...
A fully functional thymus derived from reprogrammed mouse embryonic fibroblasts has been grown in the kidney capsule of mice. ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ...
Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ... Laboratory tests that might show abnormalities include blood count, kidney function, electrolyte, and liver enzyme tests.[17] ... Chemotherapies or stem cell transplantations may require a platelet transfusion to prevent bleeding.[58][59] Moreover, patients ... Stem cell transplantation may be used if the disease recurs following standard treatment.[2] Additional treatments such as ...
The principal toxic constituent is α-amanitin, which damages the liver and kidneys, causing liver and kidney failure that can ... Ganzert M, Felgenhauer N, Zilker T (2005). "Indication of liver transplantation following amatoxin intoxication". Journal of ... Kidney failure (either secondary to severe hepatitis[68][73] or caused by direct toxic kidney damage[64]) and coagulopathy may ... acute kidney failure, and cardiac arrest.[71][72] Death generally occurs six to sixteen days after the poisoning.[74] ...
Kidney disease, Sarcopenia, surgery recovery, Pregnancy, Osteoporosis, Ulcer and so on.[12] ...
Koppel MH, Coburn JW, Mims MM, Goldstein H, Boyle JD, Rubini ME (1969). "Transplantation of cadaveric kidneys from patients ... Individuals with pre-renal kidney failure do not have damage to the kidneys, but as in individuals with HRS, have kidney ... of the kidney circulation and worsening kidney vasoconstriction, leading to kidney failure.[12] ... The kidney failure in hepatorenal syndrome is believed to arise from abnormalities in blood vessel tone in the kidneys.[2] The ...
Meanwhile, poor growth of spleen and kidneys and pancreatic hypertrophy was observed in the soybean agglutinin-fed rats.[5][6] ... Cells fractionated by SBA do not produce graft vs host disease and can be used in bone marrow transplantation across ...
Kidney transplants: It can be found in up to 20% patients, can be related to azathioprine or cyclosporine use, and may be ... "Laparoscopic study of peliosis hepatis and nodular transformation of the liver before and after renal transplantation: natural ... It also occasionally affects spleen, lymph nodes, lungs, kidneys, adrenal glands, bone marrow, and other parts of ... Chronic conditions: End stage kidney failure, kwashiorkor, tuberculosis, and other chronic infections ...
"Biology of Blood and Marrow Transplantation. 15 (12): 1628-33. PMC 2861656 . PMID 19896087. doi:10.1016/j.bbmt.2009.07.004.. ... Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct effects of drug clearance by the ... This causes kidney damage and the high levels of potassium can cause cardiac arrhythmia. Although prophylaxis is available and ... Different drugs will affect different parts of the kidney and the toxicity may be asymptomatic (only seen on blood or urine ...
Read more about the process and details of a kidney transplantation and how they may affect your body. ... Diet and Transplantation (National Kidney Foundation) Also in Spanish * From Illness to Wellness: Life After Transplantation ( ... Kidney Transplant (National Kidney Foundation) Also in Spanish * Kidney Transplant (Mayo Foundation for Medical Education and ... Solitary Kidney (National Institute of Diabetes and Digestive and Kidney Diseases) * Travel Tips: A Guide for Kidney Patients ( ...
... few fields of medicine have undergone the rapid advances that have been seen with kidney transplantation. From the development ... Is routine ureteric stenting needed in kidney transplantation? A randomized trial. Transplantation. 2000;70:597-601.CrossRef ... Kidney Transplantation. In: Humar A., Sturdevant M. (eds) Atlas of Organ Transplantation. Springer, London. * First Online 31 ... Surgical complications after kidney transplantation. Semin Dial. 2005;18:505-10.CrossRefPubMedGoogle Scholar ...
Title: Handbook of Kidney Transplantation, Author: champmails32538, Name: Handbook of Kidney Transplantation, Length: 2 pages, ... E-book download Handbook of Kidney Transplantation {fulll,online,unlimite) KWH. E-book download Handbook of Kidney ...
... may preserve renal function and improve long-term outcomes better than calcineurin inhibitors in kidney transplantation. Dr. ... Medscape Transplantation © 2010 WebMD, LLC Cite this: Ron Shapiro. Belatacept May Change Kidney Transplantation Medicine - ... Director of Kidney, Pancreas & Islet Transplantation, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, ... A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). Am ...
... kidney, liver, pancreas and stem cell transplantation. The journal welcomes submissions focusing on the histocompatibility as ... Journal of Transplantation is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... well as related side effects and complications of those transplantations. ... Kidney transplantation is the treatment of choice for most patients with stage five chronic kidney disease (CKD). The risk of ...
... kidney, liver, pancreas and stem cell transplantation. The journal welcomes submissions focusing on the histocompatibility as ... Journal of Transplantation is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... well as related side effects and complications of those transplantations. ... Bortezomib in Kidney Transplantation. Rajeev Raghavan,1,2 Abdallah Jeroudi,1 Katafan Achkar,3,4 A. Osama Gaber,5 Samir J. Patel ...
Purchase Kidney Transplantation, Bioengineering, and Regeneration - 1st Edition. Print Book & E-Book. ISBN 9780128017340, ... Kidney Transplantation, Bioengineering, and Regeneration 1st Edition. Kidney Transplantation in the Regenerative Medicine Era. ... PART I: Kidney Transplantation. Section I: Epidemiology of kidney disease and transplantation. Section II: Donor selection and ... Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates ...
Heart transplantation (HTx) remains the gold-standard treatment for those with advaced HF. Renal failure (RF) is... ... Simultaneous heart-kidney transplantation is superior to sequential heart-kidney transplantation in renal failure heart ... Renal graft outcome in combined heart-kidney transplantation compared to kidney transplantation alone: a single-center, matched ... Combined heart-kidney transplantation: a review of recipient selection and patient outcomes. Adv Chronic Kidney Dis. 2009;16: ...
... more than 82,000 patients are waiting for kidney transplants in the United States. ... Renal transplantation has become the treatment of choice for most patients with end-stage renal disease (ESRD). At present, ... living-donor kidney transplantation followed by pancreas-after-kidney transplantation is a reasonable option. Combined kidney- ... encoded search term (Kidney Transplantation) and Kidney Transplantation What to Read Next on Medscape. Related Conditions and ...
Meanwhile Tarun himself is suffering from kidney failure. As... ... kidney transplantation johnwilliams321 please help me with my ... Varuns last wish before he lost consciousness was that his kidney be donated to his brother. The boys are fraternal twins. The ... Would you take Varun off life-support before he is officially declared dead? What are Taruns chances with Varuns kidney? What ... Meanwhile Tarun himself is suffering from kidney failure. As his parent you have to make a crucial decision. ...
Clinical operational tolerance after kidney transplantation.. Roussey-Kesler G1, Giral M, Moreau A, Subra JF, Legendre C, Noël ... In this article, we report on the medical history of 10 kidney recipients who display an immunosuppressive drug-free " ... state in recipients under immunosuppression with long-term stable graft function are major challenges in transplantation. ... which mimics the procedure of intentional immunosuppression weaning following liver transplantation. Secondly, donor age was ...
Kidney Transplantation: Analysis of 200 Cases Br Med J 1974; 4 :553 ... Kidney Transplantation: Analysis of 200 Cases. Br Med J 1974; 4 doi: (Published 07 ... On the other hand, the survival of patients undergoing renal transplantation steadily improved, the most recent survival rates ... We conclude on both social and economic grounds that renal transplantation is fully justified as a therapeutic procedure. ...
Description: For individuals who want to understand the kidney transplant process-from pre-transplant evaluation, to wait list ...
Successful Kidney Transplantation in a Patient with Unipapillary Kidney Kosoku A. , Uchida J. , Shimada H. , Kabei K. , Nishide ... Donor nephrectomy for living kidney transplantation [in Japanese] 新保 正貴 , 遠藤 文康 , 木村 貴明 , 大山 雄大 , 小松 健司 , 長浜 正彦 , 南木 浩二 , 佐久間 康 ... Simultaneous pancreas-kidney transplantation: Initial experience of a center in Japan Ono Shinichiro , Adachi Tomohiko , Hidaka ... p,The patient was a man in his sixties who received kidney transplantation from a deceased donor. … Five months after
Kidney transplantation : principles and practice. [Peter J Morris; Stuart J Knechtle;] -- Updated to reflect todays practice ... guidelines, the new edition of this comprehensive text remains the definitive resource on all aspects of renal transplantation ... Pancreas and kidney transplantation for diabetic nephropathy --. Kidney transplantation in children --. Renal transplantation ... transplantation> # Kidney Transplantation a schema:Intangible ;. schema:name "Kidney Transplantation"@en ;. . ...
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A 64-year-old man with IgA nephropathy who had received a donor kidney a long time ago complained of intermittent swelling of ... Cite this as: Reuter S, Backhaus P, Becker H: Tendon swelling after kidney transplantation. Dtsch Arztebl Int 2018; 115: 595. ... Tendon Swelling After Kidney Transplantation. Dtsch Arztebl Int 2018; 115: 595. DOI: 10.3238/arztebl.2018.0595 ... A 64-year-old man with IgA nephropathy who had received a donor kidney a long time ago complained of intermittent swelling of ...
... kidney failure, organ donation, pre-operative evaluation, post-operative care, complications, discharge, and follow-up. Must ... Live Donor Kidney Transplantation - Improving the Short and Long Term Results. * First ABO-Incompatible Kidney Transplantation ... Paired Donor Exchange Kidney Transplantation. Paired donor exchange kidney transplantation is a process in which unrelated ... Quiz on Kidney. How healthy are your kidneys? Is it possible to lead healthy lives with just a single kidney? Learn more by ...
Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease ... Kidney transplantation is a life-extending procedure.[54] The typical patient will live 10 to 15 years longer with a kidney ... "Kidney transplant". Retrieved 2009-07-20.. *^ a b c d Renal Transplants , Renal Transplantation Complications ... Kidney transplantation is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantation ...
[email protected] Abstract. Live donor kidney transplantation has become a widely sought treatment by patients with ... Nevertheless, live donor kidney transplantation may not be the realistic final solution to an international public health ... Living donor kidney transplantation in a global environment.. Delmonico FL1, Dew MA. ... this review considers live kidney transplantation from the broad scope of current international practice. Unrelated live donor ...
Provides optimal management of medical and surgical issues in kidney transplantation recipients Authoritative and up-to-date ... Kidney Transplantation offers the latest evidence-based information on the full range of dilemmas in the medical management of ... Kidney Transplantation. Book Subtitle. Practical Guide to Management. Editors. * Matthew R. Weir ... Kidney Transplantation. Practical Guide to Management. Editors: Weir, Matthew R., Lerma, Edgar V. (Eds.) ...
... access to kidney transplantation.. Kidney transplantation is the preferred treatment for kidney failure. Among kidney failure ... Kidney transplantation is the preferred treatment for kidney failure patients, but blacks are less likely to receive kidney ... Requiring a formal patient education class may help reduce disparities in kidney failure patients access to kidney ... The researchers retrospectively examined information from 1,126 kidney failure patients who were referred for kidney transplant ...
... this book analyzes the implications that transplantation and immuno ... Discussing the many complications that may occur after kidney transplantation, this source is a must for anyone caring for ... With color illustrations throughout, this book analyzes the implications that transplantation and immunosuppression can hold ...
... that has undergone desensitization show improved survival compared to those with compatible kidney transplantation. ... A study showed that positive crossmatch kidney transplantation ... Kidney transplantation. It is common knowledge that patients ... Although positive crossmatch kidney transplantation is subject to high rejection rates relative to compatible kidney ... 2020, March 12). Improving Transplantation Outcomes in Positive Crossmatch Kidney Transplantation. News-Medical. Retrieved on ...
... access to kidney transplantation should not be influenced by residence location. We determined the likelihood of kidney ... Residence location and likelihood of kidney transplantation. Marcello Tonelli, Scott Klarenbach, Braden Manns, Bruce Culleton, ... Residence location and likelihood of kidney transplantation. Marcello Tonelli, Scott Klarenbach, Braden Manns, Bruce Culleton, ... We studied kidney transplantation from deceased donors as an example of a scarce medical resource that is rationed in Canadas ...
Kidney TransplantationStudy of a JAK3 Inhibitor for the Prevention of Acute Rejection in Kidney Transplant Patients NCT00483756 ... Kidney TransplantationA 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients NCT00106639 ... Kidney TransplantationCollection of Follow-up Data From CP-690,550-treated Kidney Transplant Recipients NCT01375127 ... Kidney TransplantationStudy Comparing Standard Dose and Reduced Dose Tacrolimus With Sirolimus in Renal Transplant Patients ...
We provide comprehensive and cutting-edge treatment for people who need a kidney transplant. ... UC San Diego Healths Kidney Transplant Program is San Diego Countys largest program, caring for transplant recipients and ... Living Kidney Donation. As part of the National Kidney Registrys Paired Exchange Program, we have the unique ability to allow ... 50: In 2018, we celebrated 50 years as San Diego regions first kidney transplantation program. ...
Learn about receiving a transplant or giving your organ with this National Kidney Foundation provided information. ... Kidney Walk. The Kidney Walk is the nations largest walk to fight kidney disease. Held in nearly 100 communities, the event ... Are you at Risk for Metabolic Syndrome after Kidney Transplantation?. *What Vaccinations Do You Need? A guide for adults with ... Provides the latest information about legislation and policy relating to chronic kidney disease, transplantation and donation. ...
Kidney transplant patients had a higher risk of being hospitalized within the first several months to a year, but they had a ... Kidney transplant patients had a reduced risk of treatment failure or premature death compared with patients on long and ... Kidney transplantation found superior to intensive home hemodialysis Transplantation linked with better treatment success and ... Washington, DC (May 22, 2014) -- Compared with long and frequent home hemodialysis, kidney transplantation may allow kidney ...
... and Hospital set up a Rotary Kidney Transplant and Dialysis Centre through donation of medical equipment worth ₹40 lak ... Kidney transplantation centre inauguration at KIMS today Special Correspondent HUBBALLI , April 22, 2021 18:45 IST Updated: ... The Rotary project would now enable the Nephrology Department of KIMS to offer the services of kidney transplantation to poor ... ...
  • Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant," New England Journal of Medicine , vol. 341, no. 23, pp. 1725-1730, 1999. (
  • KDIGO clinical practice guideline for the care of kidney transplant recipients," American Journal of Transplantation , vol. 9, supplement 3, pp. (
  • Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients," Transplantation , vol. 70, no. 6, pp. 887-895, 2000. (
  • Wait list death and survival benefit of kidney transplantation among nonrenal transplant recipients. (
  • Outcomes in recipients of combined heart-kidney transplantation: multiorgan, same-donor transplant study of the International Society of Heart and Lung Transplantation/United Network for Organ Sharing Scientific Registry. (
  • Induction of allograft-specific tolerance and the detection of a "tolerance" state in recipients under immunosuppression with long-term stable graft function are major challenges in transplantation. (
  • In this article, we report on the medical history of 10 kidney recipients who display an immunosuppressive drug-free "operational tolerance" for 9.4 +/- 5.2 years. (
  • It examines evaluation, management, and procurement of living and deceased donor kidneys, the selection of suitable recipients, interpretation of graft dysfunction, and expected survival based upon a large database of information. (
  • Paired donor exchange kidney transplantation is a process in which unrelated kidney donors are matched to recipients so that compatible transplants can be performed. (
  • With the increased prevalence of kidney transplantation, transplant recipients are being treated in a variety of clinical settings - often beyond the transplant center. (
  • Kidney Transplantation offers the latest evidence-based information on the full range of dilemmas in the medical management of kidney transplant recipients before, during and after transplantation. (
  • The purpose is to help healthcare providers in all settings understand health issues unique to kidney transplant recipients and how to best provide quality care for this patient population. (
  • The audience is all providers of healthcare to kidney transplant recipients, including those in non-transplant settings. (
  • We are dedicated to providing comprehensive care for transplant recipients and living donors before, after and during transplantation. (
  • Closely monitor such recipients following transplantation and provide appropriate antiviral therapy (agents that prevent viral proliferation or antibodies directed against a specific virus). (
  • Adequate levels of vitamin-D in kidney transplant recipients is associated with lower infection risk at any time post-transplantation. (
  • Tripterygium wilfordii increases long-term kidney transplant survival among transplant recipients. (
  • Vitamin D deficiency is common in kidney transplant recipients. (
  • Cohort studies comparing adult chronic dialysis patients with kidney transplantation recipients for clinical outcomes were selected. (
  • Despite increases in the age and comorbidity of contemporary transplant recipients, the relative benefits of transplantation seem to be increasing over time. (
  • Aetiologies of mortality in our kidney transplant recipients were determined. (
  • The aim of this review is to evaluate retrospectively the incidence and aetiologies of mortality in our kidney transplant recipients. (
  • Although a validated scale exists to assess knowledge of kidney transplantation among waitlisted candidates and recipients, 6 this tool has yet to be validated among ESRD patients not on the waitlist, a population likely to have lower transplant knowledge. (
  • Methods - The researchers performed a retrospective cohort study using healthcare administrative data of all adult-incident kidney-only transplantation recipients in Ontario, Canada from 1994 to 2009. (
  • Results - Among 4,958 kidney transplant recipients, the three-year cumulative incidence of hospitalization with nontraumatic major hemorrhage was 3.5% (95% confidence interval [CI] 3.0-4.1%, 12.7 events per 1,000 patient-years) compared to 0.4% (95% CI 0.4-0.5%) in the general population (RR = 8.2, 95% CI 6.9-9.7). (
  • Conclusion - Kidney transplantation recipients have a higher risk of hospitalization with hemorrhage compared to the general population, with about 1 in 30 recipients experiencing a major hemorrhage in the three years following transplant. (
  • Between March 2010 and April 2012, the researchers biopsied 651 kidneys (taken from 369 donors through four organ procurement organizations) that were subsequently transplanted into recipients. (
  • In another study, Bertram Kasiske, MD (Scientific Registry of Transplant Recipients and Hennepin County Medical Center) and his colleagues compared the results of biopsies from kidneys that were discarded with the results of biopsies from comparable kidneys that were successfully transplanted. (
  • This compares with one-year graft survival of 92% among all deceased donor kidney transplants in the Scientific Registry of Transplant Recipients. (
  • 2. Heldal K, Hartmann A, Leivestad T, Svendsen MV, Foss A, Lien B, Midtvedt K. Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity. (
  • Thanks to new advances in anti-viral and immunosuppression drugs, hepatitis C-negative recipients can receive a kidney from a hepatitis C-positive donor. (
  • Another notable effect of KAS has been to essentially equalize the proportions of kidney transplant candidates and recipients by ethnicity . (
  • Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients is an easy to read, up to date, clinical resource written by experts in the field of kidney transplantation. (
  • The book explains how donors and recipients are selected for transplantation, how the surgical procedure is performed, and how the experts recognize and treat rejection. (
  • Drs. Reese and Goldberg have received investigator-initiated grants from Merck and AbbVie awarded to the University of Pennsylvania for trials of HCV-viremic kidney transplants into HCV-seronegative recipients, followed by antiviral treatment. (
  • Dr. Sise is supported by the NIDDK grant K23 DK117014 and has received investigator-initiated grants from Merck and AbbVie awarded to the Massachusetts General Hospital for trials of HCV-viremic kidney transplants into HCV-seronegative recipients, followed by antiviral treatment. (
  • The study is a double-blind, randomized, controlled, dose-escalation and safety study of the investigational product, autologous MSCs, to be assessed for inducing immune suppression in living donor kidney transplant recipients as compared to saline, the placebo infusion. (
  • The 1-year mortality of renal transplant patients is 6% for deceased donor recipients and 3% for living donor kidney recipients compared to 25% for patients treated with dialysis, reflecting the fact that transplant recipients represent a relatively healthier subset of patients with ESRD compared to dialysis patients. (
  • Over the years, the Program's firm commitment to transplantation has been evident through its extensive involvement with clinical research trials for it young kidney recipients who face different challenges than adult kidney recipients in regards to drug therapies and physical and cognitive growth and development. (
  • Will MICA glitter for recipients of kidney transplants? (
  • After analyzing information on 88,209 donors (176,418 kidneys), the researchers found that although the discarded kidneys in these pairs frequently had traits that are typically considered unappealing, the partner kidneys that shared many, if not all of the same traits performed well after being used for transplantation despite being used in older recipients with more medical problems. (
  • In a study of kidney transplant recipients, PPI users had an almost 2-fold increased risk of mortality compared with nonusers. (
  • In a study of white related living kidney donors and recipients, investigators found that older donors are at increased risk of end-stage renal disease (ESRD) if the recipients are older at the time of ESRD onset. (
  • In a study, recipients of A2 incompatible kidneys from living donors had a 60% higher risk for death-censored graft failure than recipients of blood type compatible kidneys. (
  • Kidney transplant recipients with pre-existing pulmonary hypertension had a 1.5-fold increased risk for death compared with recipients without the condition, a study found. (
  • However, kidney transplant recipients must remain on immunosuppressants (medications to suppress the immune system) for the rest of their life to prevent their body from rejecting the new kidney. (
  • ABO compatible kidney transplantation recipients during the same period were taken as controls. (
  • Researchers are also experimenting with splitting one kidney for two recipients. (
  • Researchers are also experimenting with splitting 1 kidney for 2 recipients. (
  • Our commitment to excellence and focus on the patient experience has led to high satisfaction for recipients and living kidney donors alike. (
  • U.S. Organ Procurement and Transplantation Network the Scientific , Registry of Transplant Recipients. (
  • Graft survival for recipients of kidneys from LUDs is similar to that from zero haplotype-matched LRDs and is at least as good as that achieved with cadaveric transplants. (
  • This policy permits A2-to-O and A2B-to-B transplantation in order to shorten the waiting time for group O and group B recipients, respectively ( 11 - 13 ). (
  • A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). (
  • Since 1988, over 455,000 kidney transplants have been performed in the United States. (
  • [ 1 ] During 2018, a record number of kidney transplants were performed in the US, including 21,167 kidney-alone and 836 kidney plus at least one additional organ. (
  • currently, more than 90,000 adult patients are waiting for kidney transplants. (
  • Although perhaps only 25% of adult patients on dialysis are being referred for transplant evaluation (probably 95% of pediatric patients with ESRD will be referred), the number of potential candidates has resulted in burgeoning waitlists and longer waiting times for patients in need of kidney transplants. (
  • [ 4 ] However, the rate of living-donor transplants began to decline in 2004 and has reached a plateau representing approximately 30% of all kidney transplantations. (
  • As the outcome for the genetically and emotionally related live donor transplants is the same, this review considers live kidney transplantation from the broad scope of current international practice. (
  • Kidney transplantation is the preferred treatment for kidney failure patients, but blacks are less likely to receive kidney transplants than whites. (
  • Among kidney failure patients, blacks are less likely to receive kidney transplants than whites for reasons that are unclear. (
  • The team retrospectively analyzed 330 patients who underwent kidney transplants between 2011 and 2017. (
  • Questions about appropriate allocation of simultaneous liver and kidney transplants (SLK) are being asked because kidney dysfunction in the context of liver failure enhances access to deceased donor organs. (
  • We are San Diego's largest program with more than 3,200 kidney transplants performed since 1968. (
  • As the only academic medical center in the region, we provide the most comprehensive array of care options for patients who receive kidney transplants, including leading-edge surgical techniques, minimally invasive robotic surgery for living donors and innovative immunosuppression treatments. (
  • However, a severe kidney shortage exists right now: while about 17,000 transplants were performed in 2016, about 100,000 patients remain on the waiting list. (
  • It's a retrospective study whose aim was to evaluate the incidence and the mortality in a population including 329 patients who received first kidney transplants from a living donor in 269 cases and cadaveric donor in 60 cases at Internal Medicine A department between June 1986 and December 2003. (
  • The study population included 329 patients who received first kidney transplants from a living donor in 269 cases and cadaveric donor in 60 cases at Internal Medicine A department between June 1986 and December 2003. (
  • We hope our work informs effective interventions and novel approaches that improve access to kidney transplants for our nation's increasingly diverse patient populations. (
  • Our transplant team performs approximately 170 kidney transplants a year, of which half are living donor transplants (where a kidney is donated by a living person). (
  • These patients are at risk for liver and kidney failure and may need organ transplants. (
  • This study will evaluate organ transplantation in HIV infected patients undergoing liver and kidney transplants. (
  • The quality of donated kidneys is fundamentally important for the longevity of kidney transplants. (
  • The Virtua Center for Organ Transplantation is the only provider of kidney transplants in South Jersey. (
  • Our team also is experienced in performing simultaneous liver-kidney transplants. (
  • We are skilled in performing all three types of pancreas transplants: simultaneous pancreas kidney, pancreas after kidney, and pancreas alone. (
  • The researchers compared the number and proportions of deceased donor kidney transplants by recipient and transplant characteristics from December 2013 through September 2018 and compared relevant trends before and after KAS implementation. (
  • Importantly, throughout the study period the number of deceased donor kidney transplants continued to increase. (
  • The predictability of leucocyte typing in kidney transplantation was assessed by an analysis of 37 kidney transplants from sibling donors. (
  • There has been a substantial increase in the number of transplants using HCV-infected kidneys across the United States. (
  • Newswise - Washington, DC (September 12, 2019) - A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many U.S. centers, and they are functioning well one year after transplantation. (
  • Our study showed that transplants with HCV- infected kidneys are now routinely performed at many centers, and they are functioning well at one year after transplant," said Dr. Reese. (
  • Our Boston hospital's transplantation services have performed more than 1,300 living-related, living-unrelated and deceased donor kidney transplants. (
  • Graft survival at one year is currently 96% for the Medical Center's living donor kidney transplants, and 92% for deceased donor kidney transplants. (
  • The National Kidney Foundation: FAQs about kidney transplants. (
  • When a diseased kidney can save a life: Tufts MC transplants Hepatitis C kidney in patient with same illness. (
  • In 2004, there were 15,977 renal transplants performed in the United States, and two-thirds of renal transplant patients are now alive 5 years after transplantation, compared to one-third on either hemodialysis or peritoneal dialysis. (
  • Management of the waiting list for cadaveric kidney transplants: report of a survey and recommendations by the Clinical Practice Guidelines Committee of the American Society of Transplantation. (
  • Since 1996, The Pediatric Nephrology and Transplantation Program has performed more than 152 kidney transplants in patients between 10 months and 19 years of age with excellent results. (
  • By the end of 2012, 6183 kidney transplants had been done at HUCH. (
  • On average, 170 kidney transplants are performed every year. (
  • Today, even patients over 70-years old receive kidney transplants. (
  • According to current estimates, more than half of these kidney transplants will function 20 years after the operation. (
  • While the one-year graft survival rates for living and/or deceased donor kidney transplants are approximately 90%, graft survival rates drop to about 80% at five years and to 50% or less at 10 years. (
  • The article, entitled "Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors," will appear online at on December 7, 2017, doi: 10.2215/CJN.06550617. (
  • Living-donor kidney transplants are further characterized as genetically related (living-related) or non-related (living-unrelated) transplants, depending on whether a biological relationship exists between the donor and recipient. (
  • In 2018, an estimated 95,479 kidney transplants were performed worldwide, 36% of which came from living donors. (
  • Once your evaluation is complete, and the Virtua team determines you're eligible for a kidney transplant, you'll be placed on a national waiting list managed by the United Network for Organ Sharing (UNOS) , the organization authorized by the federal government to maintain the database for all transplants in the United States. (
  • Our waiting times for kidney transplants are the shortest in the country. (
  • We commonly provide kidney transplants to out-of-state patients. (
  • Our advanced therapies in desensitization and paired-donor exchange have made more living kidney donor transplants possible. (
  • Kidney availability in Australia remains low and, if anything, is worsening, with only 6.8% of those on dialysis receiving transplants in 2002, compared with 11.7% a decade earlier. (
  • Many transplanted kidneys come from donors who have died. (
  • Tissue typing was simple, the organ was relatively easy to remove and implant, live donors could be used without difficulty, and in the event of failure, kidney dialysis was available from the 1940s. (
  • With these principles established, the Amsterdam Forum has set forth a comprehensive list of medical criteria that is now used internationally in the evaluation of potential kidney donors. (
  • Beginning with the selection of patients who are candidates for transplantation, this authoritative guide covers the care of the patient on the waiting list and evaluation of donors, preoperative care, induction and immunosuppression maintenance. (
  • We determined the likelihood of kidney transplantation from deceased donors among Canadian dialysis patients living in 7 geographic regions. (
  • We used Cox proportional hazards models to examine the relation between residence location and the likelihood of kidney transplantation from deceased donors over a median period of 2.4 years. (
  • There were significant differences in the likelihood of kidney transplantation from deceased donors and predicted waiting times between the different geographic regions. (
  • We studied kidney transplantation from deceased donors as an example of a scarce medical resource that is rationed in Canada's public health care system, focusing on the relation between place of residence and access to transplantation. (
  • Kidneys from deceased donors are not shared nationally in Canada. (
  • As part of the National Kidney Registry's Paired Exchange Program, we have the unique ability to allow donors who are not blood or tissue compatible to 'exchange' their kidney with a donor who is compatible. (
  • We consider transplant candidates over age 70 if they are in good overall health and will use kidneys from donors up to age 70. (
  • The percentage of the donors against which the recipient reacts is used as a predictor of the likelihood of a positive cross-match that would prevent transplantation. (
  • Children who demonstrate no antibody to CMV, VZV, and EBV are at increased risk of posttransplant primary infection, especially if they receive kidneys from donors who are seropositive for these viruses. (
  • Transplanted kidneys can come from deceased or living donors. (
  • The analysis included biopsy reports from 83 kidneys discarded due to biopsy findings, 83 contralateral transplanted kidneys from the same donor, and 83 deceased donors randomly matched to cases by donor risk profile. (
  • L iving donors , who are willing to donate a kidney as a gesture of love or altruism. (
  • However, for patients whose immune systems are so sensitized that they're compatible with very few donors, the kidney committee recognized that points alone would not be enough: these patients would need access to a broader geographic pool of kidneys. (
  • Prior to 2015, many kidneys from donors with HCV were discarded, but since then, studies have shown that physicians can successfully transplant these kidneys and treat the infection with antiviral medications after transplantation. (
  • The discard rate of kidneys from deceased donors has continued to increase in the United States. (
  • Despite this shortage, almost 1 out of every 5 kidneys that are recovered from possible donors ends up being discarded- a proportion that has risen over the past decade. (
  • We therefore aimed to identify kidney donors from whom 1 kidney was used but the partner kidney in the pair was discarded," Dr. Mohan explained. (
  • The current discard of kidneys would be hard to explain to the families of deceased donors and is a disservice to the thousands of older age and diabetic wait-listed patients who would benefit from transplantation with these higher risk kidneys and who have consented to receive them," they wrote. (
  • A study of 1029 living kidney donors in Norway found that they had significant 64% increased odds of ischemic heart disease compared with health controls. (
  • In a study, cardiovascular structure and function at 5 years did not differ significantly among living kidney donors and healthy controls. (
  • Kidney donation is a widely recognized procedure in spite of some risks associated with it for living donors. (
  • More than 90% transplantations are done with living donors. (
  • Most transplanted kidneys come from deceased organ donors. (
  • Donors can come from any part of the U.S. A child receiving a transplant usually receives only one kidney. (
  • Donors can come from any part of the U.S. A child receiving a transplant usually receives only 1 kidney. (
  • Our experienced multidisciplinary team serves our community with consistently high scores in outcomes and kidney transplant rates from deceased donors, and also offers laparoscopic donor nephrectomy procedures to promote faster recovery for living kidney donors. (
  • Kidneys come from living donors or brain dead or recently cadaveric donors. (
  • The Rotary project would now enable the Nephrology Department of KIMS to offer the services of kidney transplantation to poor and needy patients, Mr. Porwal said. (
  • Washington, DC (September 11, 2014) -- Concerns about pursuing kidney transplantation are highly prevalent among kidney failure patients, particularly older adults and women, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology ( CJASN ). (
  • Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients. (
  • There are many potential reasons why a candidate might delay completing the testing required for transplant evaluation, according to Talamantes and senior author Edmund Huang, associate professor of nephrology with UCLA Health and acting associate professor in nephrology and the Kidney Transplant Program at Cedars-Sinai. (
  • Biopsies of donated kidneys provide little information for determining the suitability of organs for transplantation, according to two studies appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). (
  • Since 1996, The Pediatric Nephrology and Transplantation Program has been improving the quality of life for New Jersey's youngest patients with renal disease, renal dysfunction and hypertension. (
  • When a child's kidneys are not working, the whole body's physiology changes," explains Isabel Roberti, M.D., Director of Pediatric Nephrology and Transplantation. (
  • The findings, which come from a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), provide further evidence that many of the donated kidneys that are discarded are in fact suitable for use. (
  • The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS). (
  • Dr. Robert S. Gillespie Medical Director, Nephrology and Kidney Transplantation, and Dr. Blake W. Palmer, Medical Director, Urology Cook Children's Medical Center, join together in a discussion about the unique challenges of kidney transplant in children and how Cook Children's nephrology and urology programs partner to achieve the best possible results. (
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. (
  • Multiple arteries in live donor renal transplantation: surgical aspects and outcomes. (
  • kidney transplantation (KT) after isolated HTx improves outcomes in these scenarios. (
  • It is common knowledge that patients who received kidneys as a result of compatibility with human leukocyte antigen (HLA) antibody matching rather than positive crossmatch kidney transplantation (KT) demonstrate better outcomes. (
  • The team investigated whether post-transplant outcomes of CDC positive (CDC+FC+) and FC positive patients (CDC-FC+) undergoing kidney transplantation were successful in the instance they were desensitized using an antibody targeted against a DSA. (
  • The results support the need to encourage transplantation for potential candidates who are receiving home hemodialysis, but they also indicate that long and frequent home hemodialysis provides good outcomes for patients. (
  • The gap in clinical outcomes between all forms of kidney transplantation and the putative best forms of dialysis is large. (
  • Our patients may be invited to take part in a study that contributes to the understanding of transplantation immunobiology, clinical outcomes and how to better facilitate successful and safe transplantation in both the short and long term. (
  • Chirag Parikh, MD, PhD and Isaac Hall, MD, MS (Yale University and Veterans Affairs Medical Center) led a team that looked for associations between biopsy-reported kidney injury at the time of organ procurement with subsequent kidney transplant outcomes. (
  • They also compared outcomes for HCV-infected kidneys to similar quality HCV-uninfected kidneys. (
  • The majority of discarded kidneys could have potentially been transplanted with good outcomes. (
  • ABO-incompatible transplantation should increase "live donor" kidney transplantation, reduce waiting times, and improve patient outcomes. (
  • Comparison of combination plasmapheresis/IVIg/Anti-CD20 versus high-dose ivig in the treatment of antibody-mediated rejection," American Journal of Transplantation , vol. 9, no. 5, pp. 1099-1107, 2009. (
  • Although this therapy improved the results of transplantation, acute rejection and complications associated with steroid therapy persisted. (
  • Until the routine use of medications to prevent and treat acute rejection, introduced in 1964, deceased donor transplantation was not performed. (
  • Although positive crossmatch kidney transplantation is subject to high rejection rates relative to compatible kidney transplantation, the use of desensitization improves patient survival overall in positive crossmatch cohorts. (
  • Cordyceps may reduce the need for anti-rejection drugs and improve the outcome of renal transplantation. (
  • Kissmeyer-Nielsen F, Olsen S, Petersen VP, Fjeldborg O. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. (
  • With nearly three quarters of their patients receiving kidneys through living donation - mostly from their parents - the program consistently exceeds national averages for both short-term and long-term graft survival rates and acute rejection rates. (
  • Zou Y, Stastny P, Susal C, Dohler B, Opelz G. Antibodies against MICA antigens and kidney transplant rejection. (
  • Kidney transplant rejection can be classified as cellular rejection or antibody-mediated rejection. (
  • If rejection is suspected, a kidney biopsy should be obtained. (
  • This study is designed to investigate the efficacy and safety of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) on chronic antibody-mediated rejection (cAMR) after kidney transplantation. (
  • Biomarkers of kidney injury and rejection. (
  • Cross-compatibility (cross-matching) when positive transplantation is not permitted due to increased risk of vascular and hyperacute rejection in the early post-transplant period. (
  • Early complications involve poor kidney function, possibly because of acute rejection, cyclosporine toxicity, ischemia prior to kidney revascularization due to prerenal and postrenal problems, cytomegalovirus or Ebstein-Barr infection. (
  • Is microdialysis useful for early detection of acute rejection after kidney transplantation? (
  • Acute rejection following kidney transplantation (KTx) is still one of the challenging complications leading to chronic allograft failure. (
  • There is a higher risk of graft loss in ABO-incompatible (ABOi) kidney transplantation ( 8 , 9 ) since stimulated antibodies can bind directly to blood group antigens on the renal endothelial surface and cause acute rejection (AR). (
  • Background: Simultaneous pancreas- kidney transplantation (SPK) is an established therapy for diabetes mellitus (DM) patients with associated end stage renal disease. (
  • Talk with a member of the Virtua kidney and pancreas transplant team. (
  • As part of your transplant evaluation, our multidisciplinary team conducts a thorough evaluation to determine if a kidney and/or pancreas transplant would both extend your life and improve your quality of life. (
  • Quality of life after kidney and pancreas transplantation: a review. (
  • Are you interested in clinical kidney, pancreas and islet transplantation? (
  • To learn more about multiple listing, download this brochure from UNOS or contact the Virtua kidney and pancreas transplant coordinator. (
  • Pancreas and kidney transplantation for diabetic nephropathy. (
  • Kidney transplantation is the treatment of choice for most patients with stage five chronic kidney disease (CKD). (
  • US Renal Data System, "USRDS 2009 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States," Chapter 7, page 292, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md, USA, 2009. (
  • Indications for kidney transplantation include chronic kidney disease (CKD) and renal tumors. (
  • The calcifications can be explained by hyperparathyroidism against the background of long-term chronic kidney disease and calcium pyrophosphate deposition. (
  • Provides the latest information about legislation and policy relating to chronic kidney disease, transplantation and donation. (
  • Abstract Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. (
  • With advances in kidney transplant methods and improvement in transplant success, a kidney transplant is now widely considered to be the best way of treating chronic kidney disease for many people. (
  • We provide a specialist monthly pre-pregnancy counselling clinic for patients with chronic kidney disease and for those who have had a kidney transplant. (
  • Before the advent of immunosuppression , kidney transplantation was limited to identical twins and was not applicable to the vast majority of patients with ESRD. (
  • Firstly, most of the patients interrupted immunosuppression over a long time period (until 4 years), which mimics the procedure of intentional immunosuppression weaning following liver transplantation. (
  • With color illustrations throughout, this book analyzes the implications that transplantation and immunosuppression can hold for patients. (
  • Modern Immunosuppression Regimens in Kidney Transplantation, Current Concepts in Kidney Transplantation Sandip Kapur, IntechOpen, DOI: 10.5772/54092. (
  • HIV infected people with end stage kidney and liver disease are now potential candidates for transplantation, yet patients and clinicians lack the necessary data to determine the safety and efficacy of transplantation and immunosuppression in this group. (
  • We report a successful kidney transplant (A1 donor to an O recipient), with antibody removal pre- and post-transplant, and pre-transplant administration of anti-CD20 monoclonal antibody (rituximab), intravenous immunoglobulin, and conventional transplant immunosuppression. (
  • From the development of the surgical techniques necessary for transplantation at the beginning of the century to the dawn of modern transplantation with the introduction of immunosuppressants in the late 1950s, and to its current status as the treatment of choice for end-stage renal disease (ESRD), renal transplantation has enjoyed remarkable progress. (
  • Kidney transplantation is the treatment of choice for a minority of patients with end-stage renal disease (ESRD). (
  • The rising incidence of lifestyle related diseases like diabetes and hypertension has risen and has resulted in alarming rise of kidney disease in the world. (
  • Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease . (
  • [4] ( It was not until June 17, 1950, when a successful transplant was performed on Ruth Tucker, a 44-year-old woman with polycystic kidney disease , by Dr. Richard Lawler [5] at Little Company of Mary Hospital in Evergreen Park, Illinois. (
  • Thanks to new medications for hepatitis C, we can transplant some kidneys from patients with hepatitis C into patients without hepatitis C. We can then treat the kidney recipient for the disease after the transplant. (
  • Because kidney disease often has no symptoms, it can go unnoticed until it is very advanced. (
  • The Kidney Walk is the nation's largest walk to fight kidney disease. (
  • Get help navigating the challenges of kidney disease, organ donation and transplantation. (
  • If the work can be replicated in humans, patients suffering from end-stage kidney disease could one day have "an organ that's grown on demand-a tailored organ that can be transplanted and replaces the failing organ," says study author Harald Ott , a bioengineer at the Massachusetts General Hospital in Boston. (
  • Kidney disease kills more than 50,000 people each year-more than auto accidents, drug overdoses, or suicides. (
  • Age, sex, cause of end-stage renal disease (glomerulonephritis, diabetes, or other causes), pretransplant cardiovascular disease, vascular calcifications, time from first treatment for end-stage renal disease to kidney transplantation and acute tubular necrosis were recorded. (
  • Individuals with end-stage renal disease can get on a kidney transplant waiting list, but if they are "inactive" they are not eligible to receive a deceased donor kidney. (
  • Kidney transplantation is the preferred treatment modality for the majority of patients with end-stage renal disease (ESRD). (
  • Ultimately, this would reduce bias when interpreting results, allow researchers to compare results across study sites and kidney disease populations, and improve researchers' ability to identify which interventions have the greatest effect on improving patient transplant knowledge and in turn, access to kidney transplantation. (
  • Kidney transplantation is a lifesaving procedure for people with end-stage kidney disease. (
  • Kidney transplantation is a good treatment option for people with kidney disease. (
  • John & Meg Brogan's story: Two generations survive hereditary life-threatening kidney disease. (
  • USRDS 2004 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. Available at: (
  • Kidney transplantation halts cardiovascular disease progression in patients with end-stage renal disease. (
  • Recurrent and de novo glomerular disease after renal transplantation: a report from Renal Allograft Disease Registry (RADR). (
  • The influence of native nephrectomy on the incidence of recurrent disease following renal transplantation for primary glomerulonephritis. (
  • The most common indications for kidney transplantation are glomerulonephritis, cystic kidney disease, and type 1 diabetes. (
  • World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. (
  • Many patients with kidney disease are at high risk for severe COVID-19 illness, according to a CDC update. (
  • Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. (
  • The goal of the guidance is to educate providers and patients with kidney disease about transplantation as a treatment option. (
  • In a kidney transplant, a patient with advanced renal (kidney) disease or kidney failure receives a healthy kidney from a living donor or from a recently deceased donor. (
  • For select patients, a kidney transplant can provide a very effective treatment of their renal disease-allowing them to function normally with few dietary restrictions, minor physical limitations, and continued maintenance on medications. (
  • During Fabry disease, progressive glycosphingolipid deposition in the kidney causes gradual deterioration of renal function with proteinuria, uremia and hypertension. (
  • Given the excellent graft and patient survival generally nowadays, kidney transplantation is the first choice to correct renal dysfunction and improve the overall prognosis of patients with renal failure because of Fabry disease. (
  • Patients are assessed and counselled on the risks of pregnancy to their kidney function as well as the increased risks that kidney disease or transplantation puts on a pregnancy. (
  • Cutaneous disease in kidney transplantation patients. (
  • A kidney transplantation is the treatment of choice for patients of end stage renal disease. (
  • All patients at end stage kidney disease are theoretically eligible for kidney transplantation. (
  • He also had emphysema of both lungs, squamous cell carcinoma of his left lung, and kidney disease. (
  • Vascular complications after living donor renal transplantation: study of risk factors and effects on graft and patient survival. (
  • Improved survival of patients with end-stage heart failure listed for heart transplantation: analysis of organ procurement and transplantation network/U.S. United Network of Organ Sharing data, 1990 to 2005. (
  • Marked improvements in early graft survival and long-term graft function have made kidney transplantation a more cost-effective alternative to dialysis. (
  • On the other hand, the survival of patients undergoing renal transplantation steadily improved, the most recent survival rates at one, two, and three years being 83%, 78%, and 67%, whereas the overall rates were 74%, 66%, and 54% respectively. (
  • A team headed by Deok Gie Kim from the Yonsei University College of Medicine, Republic of Korea, has conducted a study to demonstrate that patients subject to positive crossmatch kidney transplantation that has undergone desensitization show improved survival compared to those with compatible kidney transplantation. (
  • A positive crossmatch will indicate a lack of suitability for kidney transplantation but owing to the long waitlist for patients on dialysis, patients must rely on positive crossmatch kidney transplantation for survival. (
  • In general, however, both graft and patient survival rates seen in the desensitized positive cross-match patients were comparable to compatible kidney transplantation. (
  • Graft survival at one year was 80% for kidneys contralateral to discarded kidneys. (
  • If the discarded kidneys had been transplanted with the same graft survival as the transplanted kidneys from the opposite side, many patients may have benefited," said Dr. Kasiske. (
  • In Finland, the survival rate after a kidney transplant has improved over the years, and the current results are high in international comparisons. (
  • Two recent studies have investigated the role of MICA antibodies in graft survival in kidney transplantation. (
  • Terasaki PI, Ozawa M, Castro R. Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival. (
  • Research has shown that kidney transplantation results in longer survival, better quality of life, and long-term cost savings compared with dialysis for patient with kidney failure. (
  • Reducing these concerns may help decrease disparities in access to transplantation. (
  • The OPTN is currently working to improve geographic disparities in access to transplantation of all organs," Klassen added. (
  • Traditionally, access to transplantation is rationed according to the anticipated benefit to individual patients compared with dialysis treatment. (
  • 1 , 2 This practice is generally accepted because, unlike most other scarce medical resources, access to transplantation cannot be enhanced simply by increased resource allocation. (
  • In contrast, access to transplantation among suitable candidates should not be influenced by characteristics such as age, sex, race, socioeconomic status or residence location. (
  • 3 Compared with other industrialized nations, Canada is characterized by its large size and relatively few transplant centres, which suggests that access to transplantation may be influenced by geographic considerations. (
  • It's clear that while access to transplantation improved for ethnic minorities, geographic differences in access remain," said Klassen. (
  • Ureteral stents are associated with reduced risk of ureteral complications after kidney transplantation: a large single center experience. (
  • Surgical complications after kidney transplantation. (
  • Vascular and lymphatic complications after kidney transplantation. (
  • INTRODUCTION] Symptomatic lymphocele is one of the most frequent complications after kidney transplantation and belongs to the family of perirenal fluid collections such as hematoma and urinoma. (
  • In 2018, we celebrated 50 years as San Diego region's first kidney transplantation program. (
  • Since September 2018, most HCV-infected kidneys were transplanted into patients without the infection. (
  • change in the use of HCV-infected kidneys: until September 2018, most HCV-infected kidneys were transplanted into patients with pre-existing HCV, but since September 2018, the majority of HCV-infected kidneys were transplanted into patients without the infection. (
  • Unrelated live donor transplantation can now be performed for incompatible donor recipient pairs via a simultaneous paired kidney donation. (
  • Rotary Club of Hubballi has helped Karnataka Institute of Medical Sciences (KIMS) and Hospital set up a Rotary Kidney Transplant and Dialysis Centre through donation of medical equipment worth ₹40 lakh. (
  • It was a Hyderabad based kidney donor , whose bitter experience in Turkey after not getting the promised amount of Rs 20 lakhs, exposed this illegal organ donation racket whose tentacles are spread to Turkey, Egypt and Sri Lanka. (
  • Also learn about living donation and what to consider if you are thinking of donating a kidney to someone in need. (
  • Psychosocial aspects of kidney transplantation and living kidney donation. (
  • Ethical and legal aspects of kidney donation. (
  • If you live outside of New York state, you can be on ECMC's kidney donation waiting list and stay on the list in your hometown, too. (
  • They merged Organ Procurement and Transplantation Network/United Network for Organ Sharing data with zip code socioeconomic data from the 2000 U.S. census. (
  • A fter four years, the system has largely achieved the goals set out by the Organ Procurement and Transplantation Network Kidney Transplantation Kidney Transplantation Committee," said David Klassen, MD, UNOS chief medical officer. (
  • An update to the Organ Procurement and Transplantation Network policy stipulates dual confirmation of the donor A or AB subtype. (
  • The investigators also found that donor kidney biopsies frequently underreported acute kidney injury with substantial variability. (
  • however, as they currently relate to reported acute kidney injury, they provide little utility for determining the overall risk of delayed organ function or even premature organ failure," said Dr. Parikh. (
  • Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates," Transplantation , vol. 89, no. 11, pp. 1385-1390, 2010. (
  • This study provides some evidence to test an intervention of a patient education program for potential transplant candidates in a randomized controlled study to examine whether this improves access to kidney transplantation for poor or minority patients," said Dr. Patzer. (
  • Of the more than 100,000 candidates on the kidney transplant waiting list in the U.S., approximately 30 percent are on inactive status. (
  • They then determined the cumulative incidence of conversion to active waitlist status, death and delisting before conversion among 84,783 temporarily inactive adult kidney candidates from 2004 to 2012. (
  • In general, KAS has improved the equity of candidates' access to kidney transplantation, notably by immune sensitization and candidate ethnicity. (
  • The 2016 report on deceased donor kidney transplantation was the first study of its kind detailing how specific factors account for disparities in candidates' transplant access. (
  • Here, we performed ABO genotyping in blood samples, analyzed grouping discrepancies, and investigated the weak A subgroup frequency in kidney transplantation candidates. (
  • The recipient, Richard Herrick, died eight years after the transplantation. (
  • Kidney Health Australia is endorsed as a Deductible Gift Recipient and donations of $2 and over are tax deductible in Australia. (
  • Transplantation of adult kidneys from either sex into a recipient of the opposite sex followed by ischemia at a remote time resulted in ischemia recovery that reflected the sex of the recipient, not the donor, revealing that the host sex determines recovery. (
  • Scales that are assessed for validity or reliability using transplant candidate or recipient populations may not be generalizable in measuring their intended constructs (ie, transplant knowledge) among ESRD patients who have yet to reach the kidney transplant waitlist. (
  • This guide to the care of the kidney transplant recipient aims to provide practical guidelines for management of the post-transplant recipient and is targeted to community nephrologists and general internists who care for the patient with a kidney transplant. (
  • The renal pedicle was ligated with 7-0 silk suture and the recipient left kidney was removed leaving place for the donor kidney. (
  • A positive cross match test means that the donor (whether live or deceased) is not compatible with the recipient, and therefore cannot donate a kidney. (
  • Please contact us at 716-898-5001 and we will provide you with all the information you need to become a successful kidney transplant recipient. (
  • Although a relatively simple operation, a kidney transplantation is not a simple task, neither for the recipient nor for the medical team. (
  • To avoid complications, the kidney transplant recipient must be evaluated by the medical team prior to the operation to ensure eligibility for this procedure. (
  • Pitfall in genetic screening in a pregnancy involving an allogeneic hematopoietic stem cell transplantation recipient. (
  • After the education program was implemented, 80.4% of patients completed a kidney transplant evaluation within one year, while before the program only 44.7% completed the evaluation during that time. (
  • Studies show that kidney transplantation prolongs patient lifespan compared with dialysis. (
  • The risk of being admitted to the hospital and spending a longer time in the hospital was higher for some kidney transplant patients up to a year after transplantation, but lower in the long term compared with dialysis patients. (
  • You may be listed with both the Virtua Center for Organ Transplantation and any other hospital that provides transplant services. (
  • Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. (
  • This study will evaluate the safety and efficacy of solid organ transplantation in people with HIV infection by following a prospective, multi-center cohort of HIV infected people who undergo kidney or liver transplantation. (
  • However, the long-term graft failure rates still remain a major problem in kidney (and other solid organ) transplantation. (
  • The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. (
  • Clinical operational tolerance after kidney transplantation. (
  • In an editorial accompanying Dr. Kasiske's article, Sayeed Khan Malek, MD (Brigham and Women's Hospital) wrote, "When the biopsy findings are consistent with the clinical evaluation of the donor, they are useful in making the determination about transplanting the kidney. (
  • for the Clinical Practice Guidelines Committee of the American Society of Transplantation. (
  • This course is also for anyone interested in the research and knowledge on clinical transplantation. (
  • We revealed one clinical case of unexplained and irreversible early graft dysfunction in a serologically matched pair, and it was verified by genotyping as A1-to-A2 transplantation. (
  • Two patients had received cadaveric kidneys and the others had received kidneys from living donor. (
  • To investigate, Vishnu S. Potluri, MD, MPH, David S. Goldberg, MD, MSCE and Peter P. Reese, MD, MSCE (University of Pennsylvania) and their colleagues analyzed 2015-2019 national transplant registry data on the use of HCV-infected kidneys. (
  • Live donor kidney transplantation has become a widely sought treatment by patients with end-stage renal failure. (
  • However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. (
  • Nevertheless, live donor kidney transplantation may not be the realistic final solution to an international public health epidemic of renal failure that is the result of an aging population of patients that have had inadequate preventive medical care. (
  • In the future, it may also be harder for patients with pre-existing HCV infection to get access to these HCV-infected organs for transplantation. (
  • Focuses on the stand of the Russian government on the trade of organs for transplantation. (
  • Altogether these results question whether routine procurement biopsies result in discarding kidneys that could be acceptable for many of the patients who die waiting for a kidney transplant," he added. (
  • There is specific concern that some patients who undergo combined liver and kidney transplantation may have reversible renal failure. (
  • METHOD AND PROCEDURES] One hundred and seventy-five patients with renal failure were performed kidney transplantation at our institution between April 2004 and September 2010. (
  • A year later, in 1960, the first successful living kidney transplant in the UK occurred, when Michael Woodruff performed one between identical twins in Edinburgh. (
  • Schaffer JM, Chiu P, Singh SK, Oyer PE, Reitz BA, Mallidi HR. Heart and combined heart-kidney transplantation in patients with concomitant renal insufficiency and end-stage heart failure. (
  • Meanwhile Tarun himself is suffering from kidney failure. (
  • Kidney failure patients-particularly blacks and those living in poor neighborhoods-who take part in an education program are more likely to get evaluated for a kidney transplant. (
  • Requiring a formal patient education class may help reduce disparities in kidney failure patients' access to kidney transplantation. (
  • Kidney transplantation is the preferred treatment for kidney failure. (
  • The researchers retrospectively examined information from 1,126 kidney failure patients who were referred for kidney transplant evaluation between 2005 and 2008. (
  • Did you know that African Americans are 3 times more likely to experience kidney failure? (
  • Washington, DC (May 22, 2014) -- Compared with long and frequent home hemodialysis, kidney transplantation may allow kidney failure patients to be successfully treated and to live longer, but it may also increase their risk of being hospitalized within the first year. (
  • Many studies have shown that kidney failure patients can receive many benefits from home hemodialysis that is done more often and for a longer stretch of time than is typically done in dialysis centers. (
  • Kidney transplant patients had a 55% to 61% (depending on organ donor type) reduced risk of treatment failure or death during the study compared with patients on long and frequent home hemodialysis. (
  • Kidney transplant patients had a reduced risk of treatment failure or premature death compared with patients on long and frequent home hemodialysis. (
  • Kidney failure is on the rise and currently afflicts 2 million people worldwide. (
  • There are thousands of patients with kidney failure who lack access to kidney transplantation, and disparities persist in terms of race, age, sex, and other patient characteristics. (
  • There have been tremendous advances in our ability to support kidney failure with various forms of dialysis, medication, diet and replacement of the failed kidneys through transplantation," explains Dr. Roberti. (
  • These are the most common causes of kidney failure in children from birth to age 4. (
  • These are the most common cause of kidney failure in children between ages 5 and 15. (
  • The most common cause of kidney failure in children between ages 15 and 19. (
  • Most women who have chronic kidney failure are infertile. (
  • Chronic kidney failure : renal replacement therapy. (
  • T he treatment alternatives available to Australians with endstage kidney failure are dialysis, transplantation or no active treatment. (
  • The last of these options allows kidney failure to progress spontaneously to uraemia and death. (
  • There is a new "minor antigen" gaining attention in the field of human leukocyte antigen (HLA) testing and kidney transplantation: the major-histocompatibility-complex (MHC) class I-related chain A, or MICA antigen. (
  • This surgical procedure is useful in treating patients with kidney diseases - including loin pain hematuria syndrome and nutcracker syndrome - and those who have debilitating pain and bloody urine. (
  • Learn how our highly skilled team works across divisions to manage the full range of kidney diseases in children, including dialysis and kidney transplantation. (
  • Ramos EL, Tisher CC. Recurrent diseases in the kidney transplant. (
  • Diseases that affect the blood vessels (glomeruli) in the kidneys. (
  • Not all children with these diseases will need a kidney transplant. (
  • Approximately 150 kidney and 125 liver transplant patients will be enrolled in this study over a 3-year period at medical research centers throughout the United States. (
  • However, it is currently performed only in a few transplantation centers in the world, due to the anastomoses complexity (renal artery diameter 0.3 mm). (
  • Sixty-three renal transplantation centers affiliatedfiliated with the Brazilian Transplantation Registry (accounting for more than 95% of the transplantation activity in Brazil). (
  • For patient education information, see Kidney Transplant and the Mayo Clinic's kidney transplant information Web page. (
  • In an attempt to educate patients about the transplant process, the Emory Transplant Center's kidney program implemented a required educational session in 2007 for each patient who was referred for a kidney transplant evaluation. (
  • Dorry Segev, MD, PhD (Johns Hopkins University School of Public Health) and his colleagues conducted a study to understand the concerns and perceived barriers that dialysis patients have about pursuing transplantation, and what patient characteristics are associated with such concerns. (
  • We recommend that patients with limited English proficiency who are in need of a kidney transplant use patient advocates who are English-proficient during transplant clinic visits and always use interpreters to get all of their questions answered. (
  • Measuring Patient Knowledge of Kidney Transplantation: An In. (
  • Nevertheless, there are widely recognized disparities in access to each of the required steps preceding receipt of a kidney transplant, including provision of patient transplant education. (
  • 2 Nevertheless, the death rate on dialysis is higher than after transplantation even after adjusting for patient characteristics. (
  • The largest kidney patient charity in the UK. (
  • It is divided in 4 modules: 1) Before the transplant 2) The surgical procedures and the challenged patient, including the patient with diabetes 3) Early challenges 4) Late challenges after transplantation. (
  • The benefit of enzyme-replacement therapy (ERT) in kidney transplanted Fabry patients has been controversially discussed and long-term trials focusing on the effectiveness of agalsidase in this patient population are needed. (
  • Bitker MO, Benoit G. Surgical aspects of kidney transplantation in France in 1997. (
  • Various methods to increase the supply of available kidneys have proven to be either unworkable or insufficient to significantly allay the shortage. (
  • Unfortunately, because of a shortage of available kidneys, there is a long waitlist to receive a transplant, and approximately 5000 patients in the Unites States die each year waiting for a kidney transplant. (
  • Join The Cato Institute for this panel discussion, which will explore various ways to alleviate the critical shortage of available kidneys. (
  • To increase the success rate, a two-stage procedure was performed, i.e. the left native kidney was removed at the time of grafting and the right native kidney was left in place until day 7, when the right nephrectomy was performed. (
  • In order to provide the best care for your child, providers on the Kidney Transplant team closely collaborate with departments and specialties across Children's National. (
  • We will then schedule a date for you to come to ECMC for a full day of education, testing, and meeting with the kidney transplant team. (
  • The era of modern renal transplantation began with the introduction of the immunosuppressive agent azathioprine, and renal transplantation was established as a viable option for the treatment of ESRD. (
  • Although the donated kidney was rejected ten months later because no immunosuppressive therapy was available at the time-the development of effective antirejection drugs was years away-the intervening time gave Tucker's remaining kidney time to recover and she lived another five years. (
  • Primary contraindications for a kidney transplantation are poor cardiac, circulatory, or neurological conditions causing the patients to be too weak to endure the surgery and the subsequent immunosuppressive therapy. (
  • Renal transplantation at the University of Wisconsin in the cyclosporine era. (
  • Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies," American Journal of Transplantation , vol. 10, no. 3, pp. 681-686, 2010. (
  • This is called a cross match and it is done to make sure there are no substances in the blood, called cytotoxic antibodies, that may cause the recipient's body to reject the transplanted kidney. (
  • One of the earliest mentions about the possibility of a kidney transplant was by American medical researcher Simon Flexner , who declared in a reading of his paper on "Tendencies in Pathology" in the University of Chicago in 1907 that it would be possible in the then-future for diseased human organs substitution for healthy ones by surgery , including arteries, stomach, kidneys and heart . (
  • Commissioner said that on August 11, Malik informed the victim about his travel to Turkey to undergo surgery and removal of the victim's kidney. (
  • On August 27, Kidney transplantation surgery was conducted at Kent Hospital. (
  • Before receiving a kidney transplant, a person with ESRD must undergo a thorough medical evaluation to make sure that they are healthy enough to undergo transplant surgery. (
  • A kidney transplant is surgery to place a healthy kidney from another person into someone with severe kidney problems. (
  • In most cases, the diseased kidneys are left in place during the surgery. (
  • Doctors who specialize in transplantation and who will be performing the surgery. (
  • The researchers examined the three-year cumulative incidence of hospitalization with major nontraumatic hemorrhage after kidney transplantation. (
  • In particular, the researchers compared biopsies of both kidneys from the same donor, when one kidney was transplanted and the other was discarded. (
  • In January, UNOS staff researchers Darren Stewart and Amber Wilk, Ph.D., along with Klassen, published a review article, " KAS Turns Four: The State of Deceased Donor Kidney Allocation in the U.S. ", in a special issue of OBM Transplantation. (
  • Washington, DC (December 7, 2017) - When researchers examined information on pairs of kidneys from the same donor in which 1 kidney was used but the other was discarded, the kidneys that were used tended to perform well even though they were similar in quality to their partner kidneys that were not used. (
  • Murray was awarded the Nobel Prize in Physiology or Medicine in 1990 for his work in organ transplantation. (
  • Vishnevsky Institute, Moscow honored him in 1971 for his pioneering work in organ transplantation and awarded him two medals for lung transplant and heart, respectively. (
  • The videos and images were of high quality and irrefutably aided in the understanding of the difficult field of transplantation immunology. (
  • The immunology of transplantation. (