The transference of a pancreas from one human or animal to another.
The transference of a kidney from one human or animal to another.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transference of a part of or an entire liver from one human or animal to another.
Pathological processes of the KIDNEY or its component tissues.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
A dead body, usually a human body.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The transference of a heart from one human or animal to another.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Prospective patient listings for appointments or treatments.
Elements of limited time intervals, contributing to particular results or situations.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
The transference of either one or both of the lungs from one human or animal to another.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
Transplantation of an individual's own tissue from one site to another site.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transference of an organ between individuals of the same species or between individuals of different species.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Pancreas transplantation is a surgical procedure that involves implanting a healthy pancreas from a deceased donor into a recipient with diabetes. The primary goal of this procedure is to restore the recipient's insulin production and eliminate the need for insulin injections, thereby improving their quality of life and reducing the risk of long-term complications associated with diabetes.

There are three main types of pancreas transplantation:

1. Simultaneous pancreas-kidney (SPK) transplantation: This is the most common type of pancreas transplant, performed simultaneously with a kidney transplant in patients with diabetes and end-stage renal disease (ESRD). The new pancreas not only restores insulin production but also helps prevent further kidney damage.
2. Pancreas after kidney (PAK) transplantation: In this procedure, a patient receives a kidney transplant first, followed by a pancreas transplant at a later time. This is typically performed in patients who have already undergone a successful kidney transplant and wish to improve their diabetes management.
3. Pancreas transplantation alone (PTA): In rare cases, a pancreas transplant may be performed without a concurrent kidney transplant. This is usually considered for patients with brittle diabetes who experience severe hypoglycemic episodes despite optimal medical management and lifestyle modifications.

The success of pancreas transplantation has significantly improved over the years, thanks to advancements in surgical techniques, immunosuppressive medications, and post-transplant care. However, it is essential to weigh the benefits against the risks, such as potential complications related to surgery, infection, rejection, and long-term use of immunosuppressive drugs. Ultimately, the decision to undergo pancreas transplantation should be made in consultation with a multidisciplinary team of healthcare professionals, considering each patient's unique medical history and personal circumstances.

Kidney transplantation is a surgical procedure where a healthy kidney from a deceased or living donor is implanted into a patient with end-stage renal disease (ESRD) or permanent kidney failure. The new kidney takes over the functions of filtering waste and excess fluids from the blood, producing urine, and maintaining the body's electrolyte balance.

The transplanted kidney is typically placed in the lower abdomen, with its blood vessels connected to the recipient's iliac artery and vein. The ureter of the new kidney is then attached to the recipient's bladder to ensure proper urine flow. Following the surgery, the patient will require lifelong immunosuppressive therapy to prevent rejection of the transplanted organ by their immune system.

A kidney, in medical terms, is one of two bean-shaped organs located in the lower back region of the body. They are essential for maintaining homeostasis within the body by performing several crucial functions such as:

1. Regulation of water and electrolyte balance: Kidneys help regulate the amount of water and various electrolytes like sodium, potassium, and calcium in the bloodstream to maintain a stable internal environment.

2. Excretion of waste products: They filter waste products from the blood, including urea (a byproduct of protein metabolism), creatinine (a breakdown product of muscle tissue), and other harmful substances that result from normal cellular functions or external sources like medications and toxins.

3. Endocrine function: Kidneys produce several hormones with important roles in the body, such as erythropoietin (stimulates red blood cell production), renin (regulates blood pressure), and calcitriol (activated form of vitamin D that helps regulate calcium homeostasis).

4. pH balance regulation: Kidneys maintain the proper acid-base balance in the body by excreting either hydrogen ions or bicarbonate ions, depending on whether the blood is too acidic or too alkaline.

5. Blood pressure control: The kidneys play a significant role in regulating blood pressure through the renin-angiotensin-aldosterone system (RAAS), which constricts blood vessels and promotes sodium and water retention to increase blood volume and, consequently, blood pressure.

Anatomically, each kidney is approximately 10-12 cm long, 5-7 cm wide, and 3 cm thick, with a weight of about 120-170 grams. They are surrounded by a protective layer of fat and connected to the urinary system through the renal pelvis, ureters, bladder, and urethra.

The pancreas is a glandular organ located in the abdomen, posterior to the stomach. It has both exocrine and endocrine functions. The exocrine portion of the pancreas consists of acinar cells that produce and secrete digestive enzymes into the duodenum via the pancreatic duct. These enzymes help in the breakdown of proteins, carbohydrates, and fats in food.

The endocrine portion of the pancreas consists of clusters of cells called islets of Langerhans, which include alpha, beta, delta, and F cells. These cells produce and secrete hormones directly into the bloodstream, including insulin, glucagon, somatostatin, and pancreatic polypeptide. Insulin and glucagon are critical regulators of blood sugar levels, with insulin promoting glucose uptake and storage in tissues and glucagon stimulating glycogenolysis and gluconeogenesis to raise blood glucose when it is low.

Graft survival, in medical terms, refers to the success of a transplanted tissue or organ in continuing to function and integrate with the recipient's body over time. It is the opposite of graft rejection, which occurs when the recipient's immune system recognizes the transplanted tissue as foreign and attacks it, leading to its failure.

Graft survival depends on various factors, including the compatibility between the donor and recipient, the type and location of the graft, the use of immunosuppressive drugs to prevent rejection, and the overall health of the recipient. A successful graft survival implies that the transplanted tissue or organ has been accepted by the recipient's body and is functioning properly, providing the necessary physiological support for the recipient's survival and improved quality of life.

Graft rejection is an immune response that occurs when transplanted tissue or organ (the graft) is recognized as foreign by the recipient's immune system, leading to the activation of immune cells to attack and destroy the graft. This results in the failure of the transplant and the need for additional medical intervention or another transplant. There are three types of graft rejection: hyperacute, acute, and chronic. Hyperacute rejection occurs immediately or soon after transplantation due to pre-existing antibodies against the graft. Acute rejection typically occurs within weeks to months post-transplant and is characterized by the infiltration of T-cells into the graft. Chronic rejection, which can occur months to years after transplantation, is a slow and progressive process characterized by fibrosis and tissue damage due to ongoing immune responses against the graft.

Liver transplantation is a surgical procedure in which a diseased or failing liver is replaced with a healthy one from a deceased donor or, less commonly, a portion of a liver from a living donor. The goal of the procedure is to restore normal liver function and improve the patient's overall health and quality of life.

Liver transplantation may be recommended for individuals with end-stage liver disease, acute liver failure, certain genetic liver disorders, or liver cancers that cannot be treated effectively with other therapies. The procedure involves complex surgery to remove the diseased liver and implant the new one, followed by a period of recovery and close medical monitoring to ensure proper function and minimize the risk of complications.

The success of liver transplantation has improved significantly in recent years due to advances in surgical techniques, immunosuppressive medications, and post-transplant care. However, it remains a major operation with significant risks and challenges, including the need for lifelong immunosuppression to prevent rejection of the new liver, as well as potential complications such as infection, bleeding, and organ failure.

Kidney disease, also known as nephropathy or renal disease, refers to any functional or structural damage to the kidneys that impairs their ability to filter blood, regulate electrolytes, produce hormones, and maintain fluid balance. This damage can result from a wide range of causes, including diabetes, hypertension, glomerulonephritis, polycystic kidney disease, lupus, infections, drugs, toxins, and congenital or inherited disorders.

Depending on the severity and progression of the kidney damage, kidney diseases can be classified into two main categories: acute kidney injury (AKI) and chronic kidney disease (CKD). AKI is a sudden and often reversible loss of kidney function that occurs over hours to days, while CKD is a progressive and irreversible decline in kidney function that develops over months or years.

Symptoms of kidney diseases may include edema, proteinuria, hematuria, hypertension, electrolyte imbalances, metabolic acidosis, anemia, and decreased urine output. Treatment options depend on the underlying cause and severity of the disease and may include medications, dietary modifications, dialysis, or kidney transplantation.

Chronic kidney failure, also known as chronic kidney disease (CKD) stage 5 or end-stage renal disease (ESRD), is a permanent loss of kidney function that occurs gradually over a period of months to years. It is defined as a glomerular filtration rate (GFR) of less than 15 ml/min, which means the kidneys are filtering waste and excess fluids at less than 15% of their normal capacity.

CKD can be caused by various underlying conditions such as diabetes, hypertension, glomerulonephritis, polycystic kidney disease, and recurrent kidney infections. Over time, the damage to the kidneys can lead to a buildup of waste products and fluids in the body, which can cause a range of symptoms including fatigue, weakness, shortness of breath, nausea, vomiting, and confusion.

Treatment for chronic kidney failure typically involves managing the underlying condition, making lifestyle changes such as following a healthy diet, and receiving supportive care such as dialysis or a kidney transplant to replace lost kidney function.

Homologous transplantation is a type of transplant surgery where organs or tissues are transferred between two genetically non-identical individuals of the same species. The term "homologous" refers to the similarity in structure and function of the donated organ or tissue to the recipient's own organ or tissue.

For example, a heart transplant from one human to another is an example of homologous transplantation because both organs are hearts and perform the same function. Similarly, a liver transplant, kidney transplant, lung transplant, and other types of organ transplants between individuals of the same species are also considered homologous transplantations.

Homologous transplantation is in contrast to heterologous or xenogeneic transplantation, where organs or tissues are transferred from one species to another, such as a pig heart transplanted into a human. Homologous transplantation is more commonly performed than heterologous transplantation due to the increased risk of rejection and other complications associated with xenogeneic transplants.

A tissue donor is an individual who has agreed to allow organs and tissues to be removed from their body after death for the purpose of transplantation to restore the health or save the life of another person. The tissues that can be donated include corneas, heart valves, skin, bone, tendons, ligaments, veins, and cartilage. These tissues can enhance the quality of life for many recipients and are often used in reconstructive surgeries. It is important to note that tissue donation does not interfere with an open casket funeral or other cultural or religious practices related to death and grieving.

A living donor is a person who voluntarily donates an organ or part of an organ to another person while they are still alive. This can include donations such as a kidney, liver lobe, lung, or portion of the pancreas or intestines. The donor and recipient typically undergo medical evaluation and compatibility testing to ensure the best possible outcome for the transplantation procedure. Living donation is regulated by laws and ethical guidelines to ensure that donors are fully informed and making a voluntary decision.

Immunosuppressive agents are medications that decrease the activity of the immune system. They are often used to prevent the rejection of transplanted organs and to treat autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. These drugs work by interfering with the immune system's normal responses, which helps to reduce inflammation and damage to tissues. However, because they suppress the immune system, people who take immunosuppressive agents are at increased risk for infections and other complications. Examples of immunosuppressive agents include corticosteroids, azathioprine, cyclophosphamide, mycophenolate mofetil, tacrolimus, and sirolimus.

Delayed graft function (DGF) is a term used in the medical field, particularly in transplant medicine. It refers to a situation where a transplanted organ, most commonly a kidney, fails to function normally immediately after the transplantation procedure. This failure to function occurs within the first week after the transplant and is usually associated with poor urine output and elevated levels of creatinine in the blood.

DGF can be caused by several factors, including pre-existing conditions in the recipient, such as diabetes or hypertension, poor quality of the donor organ, or complications during the surgery. It may also result from the immune system's reaction to the transplanted organ, known as rejection.

In many cases, DGF can be managed with medical interventions, such as administering medications to help reduce inflammation and improve blood flow to the organ. However, in some instances, it may lead to more severe complications, including acute or chronic rejection of the transplanted organ, which could require additional treatments or even another transplant.

It's important to note that not all cases of DGF lead to long-term complications, and many patients with DGF can still go on to have successful transplants with proper management and care.

Tissue and organ procurement is the process of obtaining viable tissues and organs from deceased or living donors for the purpose of transplantation, research, or education. This procedure is performed by trained medical professionals in a sterile environment, adhering to strict medical standards and ethical guidelines. The tissues and organs that can be procured include hearts, lungs, livers, kidneys, pancreases, intestines, corneas, skin, bones, tendons, and heart valves. The process involves a thorough medical evaluation of the donor, as well as consent from the donor or their next of kin. After procurement, the tissues and organs are preserved and transported to recipients in need.

Kidney tubules are the structural and functional units of the kidney responsible for reabsorption, secretion, and excretion of various substances. They are part of the nephron, which is the basic unit of the kidney's filtration and reabsorption process.

There are three main types of kidney tubules:

1. Proximal tubule: This is the initial segment of the kidney tubule that receives the filtrate from the glomerulus. It is responsible for reabsorbing approximately 65% of the filtrate, including water, glucose, amino acids, and electrolytes.
2. Loop of Henle: This U-shaped segment of the tubule consists of a thin descending limb, a thin ascending limb, and a thick ascending limb. The loop of Henle helps to concentrate urine by creating an osmotic gradient that allows water to be reabsorbed in the collecting ducts.
3. Distal tubule: This is the final segment of the kidney tubule before it empties into the collecting duct. It is responsible for fine-tuning the concentration of electrolytes and pH balance in the urine by selectively reabsorbing or secreting substances such as sodium, potassium, chloride, and hydrogen ions.

Overall, kidney tubules play a critical role in maintaining fluid and electrolyte balance, regulating acid-base balance, and removing waste products from the body.

A cadaver is a deceased body that is used for medical research or education. In the field of medicine, cadavers are often used in anatomy lessons, surgical training, and other forms of medical research. The use of cadavers allows medical professionals to gain a deeper understanding of the human body and its various systems without causing harm to living subjects. Cadavers may be donated to medical schools or obtained through other means, such as through consent of the deceased or their next of kin. It is important to handle and treat cadavers with respect and dignity, as they were once living individuals who deserve to be treated with care even in death.

Bone marrow transplantation (BMT) is a medical procedure in which damaged or destroyed bone marrow is replaced with healthy bone marrow from a donor. Bone marrow is the spongy tissue inside bones that produces blood cells. The main types of BMT are autologous, allogeneic, and umbilical cord blood transplantation.

In autologous BMT, the patient's own bone marrow is used for the transplant. This type of BMT is often used in patients with lymphoma or multiple myeloma who have undergone high-dose chemotherapy or radiation therapy to destroy their cancerous bone marrow.

In allogeneic BMT, bone marrow from a genetically matched donor is used for the transplant. This type of BMT is often used in patients with leukemia, lymphoma, or other blood disorders who have failed other treatments.

Umbilical cord blood transplantation involves using stem cells from umbilical cord blood as a source of healthy bone marrow. This type of BMT is often used in children and adults who do not have a matched donor for allogeneic BMT.

The process of BMT typically involves several steps, including harvesting the bone marrow or stem cells from the donor, conditioning the patient's body to receive the new bone marrow or stem cells, transplanting the new bone marrow or stem cells into the patient's body, and monitoring the patient for signs of engraftment and complications.

BMT is a complex and potentially risky procedure that requires careful planning, preparation, and follow-up care. However, it can be a life-saving treatment for many patients with blood disorders or cancer.

Blood group incompatibility refers to a situation where the blood type of a donor and a recipient are not compatible, leading to an immune response and destruction of the donated red blood cells. This is because the recipient's immune system recognizes the donor's red blood cells as foreign due to the presence of incompatible antigens on their surface.

The most common type of blood group incompatibility occurs between individuals with different ABO blood types, such as when a person with type O blood receives type A, B, or AB blood. This can lead to agglutination and hemolysis of the donated red blood cells, causing potentially life-threatening complications such as hemolytic transfusion reaction.

Another type of blood group incompatibility occurs between Rh-negative mothers and their Rh-positive fetuses. If a mother's immune system is exposed to her fetus's Rh-positive red blood cells during pregnancy or childbirth, she may develop antibodies against them. This can lead to hemolytic disease of the newborn if the mother becomes pregnant with another Rh-positive fetus in the future.

To prevent these complications, it is essential to ensure that donated blood is compatible with the recipient's blood type before transfusion and that appropriate measures are taken during pregnancy and childbirth to prevent sensitization of Rh-negative mothers to Rh-positive red blood cells.

Heart transplantation is a surgical procedure where a diseased, damaged, or failing heart is removed and replaced with a healthy donor heart. This procedure is usually considered as a last resort for patients with end-stage heart failure or severe coronary artery disease who have not responded to other treatments. The donor heart typically comes from a brain-dead individual whose family has agreed to donate their loved one's organs for transplantation. Heart transplantation is a complex and highly specialized procedure that requires a multidisciplinary team of healthcare professionals, including cardiologists, cardiac surgeons, anesthesiologists, perfusionists, nurses, and other support staff. The success rates for heart transplantation have improved significantly over the past few decades, with many patients experiencing improved quality of life and increased survival rates. However, recipients of heart transplants require lifelong immunosuppressive therapy to prevent rejection of the donor heart, which can increase the risk of infections and other complications.

Hematopoietic Stem Cell Transplantation (HSCT) is a medical procedure where hematopoietic stem cells (immature cells that give rise to all blood cell types) are transplanted into a patient. This procedure is often used to treat various malignant and non-malignant disorders affecting the hematopoietic system, such as leukemias, lymphomas, multiple myeloma, aplastic anemia, inherited immune deficiency diseases, and certain genetic metabolic disorders.

The transplantation can be autologous (using the patient's own stem cells), allogeneic (using stem cells from a genetically matched donor, usually a sibling or unrelated volunteer), or syngeneic (using stem cells from an identical twin).

The process involves collecting hematopoietic stem cells, most commonly from the peripheral blood or bone marrow. The collected cells are then infused into the patient after the recipient's own hematopoietic system has been ablated (or destroyed) using high-dose chemotherapy and/or radiation therapy. This allows the donor's stem cells to engraft, reconstitute, and restore the patient's hematopoietic system.

HSCT is a complex and potentially risky procedure with various complications, including graft-versus-host disease, infections, and organ damage. However, it offers the potential for cure or long-term remission in many patients with otherwise fatal diseases.

A waiting list, in the context of healthcare and medicine, refers to a list of patients who are awaiting a particular medical service or procedure, such as surgery, consultation with a specialist, or therapy. These lists are often established when the demand for certain services exceeds the immediate supply of resources, including physician time, hospital beds, or specialized equipment.

Patients on waiting lists are typically ranked based on factors like the severity of their condition, the urgency of their need for treatment, and the date they were placed on the list. The goal is to ensure that those with the most pressing medical needs receive care as soon as possible, while also providing a fair and transparent system for allocating limited resources.

However, it's important to note that extended waiting times can have negative consequences for patients, including worsening of symptoms, decreased quality of life, and potential complications. As such, healthcare systems strive to minimize wait times through various strategies, such as increasing resource allocation, improving efficiency, and implementing alternative service delivery models.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

Acute kidney injury (AKI), also known as acute renal failure, is a rapid loss of kidney function that occurs over a few hours or days. It is defined as an increase in the serum creatinine level by 0.3 mg/dL within 48 hours or an increase in the creatinine level to more than 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days, or a urine volume of less than 0.5 mL/kg per hour for six hours.

AKI can be caused by a variety of conditions, including decreased blood flow to the kidneys, obstruction of the urinary tract, exposure to toxic substances, and certain medications. Symptoms of AKI may include decreased urine output, fluid retention, electrolyte imbalances, and metabolic acidosis. Treatment typically involves addressing the underlying cause of the injury and providing supportive care, such as dialysis, to help maintain kidney function until the injury resolves.

Lung transplantation is a surgical procedure where one or both diseased lungs are removed and replaced with healthy lungs from a deceased donor. It is typically considered as a treatment option for patients with end-stage lung diseases, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, idiopathic pulmonary fibrosis, and alpha-1 antitrypsin deficiency, who have exhausted all other medical treatments and continue to suffer from severe respiratory failure.

The procedure involves several steps, including evaluating the patient's eligibility for transplantation, matching the donor's lung size and blood type with the recipient, and performing the surgery under general anesthesia. After the surgery, patients require close monitoring and lifelong immunosuppressive therapy to prevent rejection of the new lungs.

Lung transplantation can significantly improve the quality of life and survival rates for some patients with end-stage lung disease, but it is not without risks, including infection, bleeding, and rejection. Therefore, careful consideration and thorough evaluation are necessary before pursuing this treatment option.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

Kidney function tests (KFTs) are a group of diagnostic tests that evaluate how well your kidneys are functioning by measuring the levels of various substances in the blood and urine. The tests typically assess the glomerular filtration rate (GFR), which is an indicator of how efficiently the kidneys filter waste from the blood, as well as the levels of electrolytes, waste products, and proteins in the body.

Some common KFTs include:

1. Serum creatinine: A waste product that's produced by normal muscle breakdown and is excreted by the kidneys. Elevated levels may indicate reduced kidney function.
2. Blood urea nitrogen (BUN): Another waste product that's produced when protein is broken down and excreted by the kidneys. Increased BUN levels can suggest impaired kidney function.
3. Estimated glomerular filtration rate (eGFR): A calculation based on serum creatinine, age, sex, and race that estimates the GFR and provides a more precise assessment of kidney function than creatinine alone.
4. Urinalysis: An examination of a urine sample to detect abnormalities such as protein, blood, or bacteria that may indicate kidney disease.
5. Electrolyte levels: Measurement of sodium, potassium, chloride, and bicarbonate in the blood to ensure they're properly balanced, which is essential for normal kidney function.

KFTs are often ordered as part of a routine check-up or when kidney disease is suspected based on symptoms or other diagnostic tests. Regular monitoring of kidney function can help detect and manage kidney disease early, potentially preventing or slowing down its progression.

The kidney cortex is the outer region of the kidney where most of the functional units called nephrons are located. It plays a crucial role in filtering blood and regulating water, electrolyte, and acid-base balance in the body. The kidney cortex contains the glomeruli, proximal tubules, loop of Henle, and distal tubules, which work together to reabsorb necessary substances and excrete waste products into the urine.

Autologous transplantation is a medical procedure where cells, tissues, or organs are removed from a person, stored and then returned back to the same individual at a later time. This is different from allogeneic transplantation where the tissue or organ is obtained from another donor. The term "autologous" is derived from the Greek words "auto" meaning self and "logos" meaning study.

In autologous transplantation, the patient's own cells or tissues are used to replace or repair damaged or diseased ones. This reduces the risk of rejection and eliminates the need for immunosuppressive drugs, which are required in allogeneic transplants to prevent the body from attacking the foreign tissue.

Examples of autologous transplantation include:

* Autologous bone marrow or stem cell transplantation, where stem cells are removed from the patient's blood or bone marrow, stored and then reinfused back into the same individual after high-dose chemotherapy or radiation therapy to treat cancer.
* Autologous skin grafting, where a piece of skin is taken from one part of the body and transplanted to another area on the same person.
* Autologous chondrocyte implantation, where cartilage cells are harvested from the patient's own knee, cultured in a laboratory and then implanted back into the knee to repair damaged cartilage.

Tacrolimus is an immunosuppressant drug that is primarily used to prevent the rejection of transplanted organs. It works by inhibiting the activity of T-cells, which are a type of white blood cell that plays a central role in the body's immune response. By suppressing the activity of these cells, tacrolimus helps to reduce the risk of an immune response being mounted against the transplanted organ.

Tacrolimus is often used in combination with other immunosuppressive drugs, such as corticosteroids and mycophenolate mofetil, to provide a comprehensive approach to preventing organ rejection. It is available in various forms, including capsules, oral solution, and intravenous injection.

The drug was first approved for use in the United States in 1994 and has since become a widely used immunosuppressant in transplant medicine. Tacrolimus is also being studied as a potential treatment for a variety of other conditions, including autoimmune diseases and cancer.

Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.

Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.

Organ transplantation is a surgical procedure where an organ or tissue from one person (donor) is removed and placed into another person (recipient) whose organ or tissue is not functioning properly or has been damaged beyond repair. The goal of this complex procedure is to replace the non-functioning organ with a healthy one, thereby improving the recipient's quality of life and overall survival.

Organs that can be transplanted include the heart, lungs, liver, kidneys, pancreas, and intestines. Tissues such as corneas, skin, heart valves, and bones can also be transplanted. The donor may be deceased or living, depending on the type of organ and the medical circumstances.

Organ transplantation is a significant and life-changing event for both the recipient and their families. It requires careful evaluation, matching, and coordination between the donor and recipient, as well as rigorous post-transplant care to ensure the success of the procedure and minimize the risk of rejection.

Mycophenolic Acid (MPA) is an immunosuppressive drug that is primarily used to prevent rejection in organ transplantation. It works by inhibiting the enzyme inosine monophosphate dehydrogenase, which is a key enzyme for the de novo synthesis of guanosine nucleotides, an essential component for the proliferation of T and B lymphocytes. By doing this, MPA reduces the activity of the immune system, thereby preventing it from attacking the transplanted organ.

Mycophenolic Acid is available in two forms: as the sodium salt (Mycophenolate Sodium) and as the morpholinoethyl ester (Mycophenolate Mofetil), which is rapidly hydrolyzed to Mycophenolic Acid after oral administration. Common side effects of MPA include gastrointestinal symptoms such as diarrhea, nausea, and vomiting, as well as an increased risk of infections due to its immunosuppressive effects.

Polycystic Kidney Disease (PKD) is a genetic disorder characterized by the growth of multiple cysts in the kidneys. These cysts are fluid-filled sacs that can vary in size and can multiply, leading to enlarged kidneys. The increased size and number of cysts can result in reduced kidney function, high blood pressure, and eventually kidney failure.

There are two main types of PKD: Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Autosomal Recessive Polycystic Kidney Disease (ARPKD). ADPKD is the most common form, affecting approximately 1 in every 500 people. It typically develops in adulthood. On the other hand, ARPKD is a rarer form, affecting about 1 in every 20,000 children, and it often presents in infancy or early childhood.

In addition to kidney problems, PKD can also affect other organs, such as the liver and the heart. It's important to note that while there is no cure for PKD, various treatments can help manage symptoms and slow down the progression of the disease.

Transplantation conditioning, also known as preparative regimen or immunoablative therapy, refers to the use of various treatments prior to transplantation of cells, tissues or organs. The main goal of transplantation conditioning is to suppress the recipient's immune system, allowing for successful engraftment and minimizing the risk of rejection of the donor tissue.

There are two primary types of transplantation conditioning: myeloablative and non-myeloablative.

1. Myeloablative conditioning is a more intensive regimen that involves the use of high-dose chemotherapy, radiation therapy or both. This approach eliminates not only immune cells but also stem cells in the bone marrow, requiring the recipient to receive a hematopoietic cell transplant (HCT) from the donor to reconstitute their blood and immune system.
2. Non-myeloablative conditioning is a less intensive regimen that primarily targets immune cells while sparing the stem cells in the bone marrow. This approach allows for mixed chimerism, where both recipient and donor immune cells coexist, reducing the risk of severe complications associated with myeloablative conditioning.

The choice between these two types of transplantation conditioning depends on various factors, including the type of transplant, patient's age, overall health, and comorbidities. Both approaches carry risks and benefits, and the decision should be made carefully by a multidisciplinary team of healthcare professionals in consultation with the patient.

Histocompatibility testing, also known as tissue typing, is a medical procedure that determines the compatibility of tissues between two individuals, usually a potential donor and a recipient for organ or bone marrow transplantation. The test identifies specific antigens, called human leukocyte antigens (HLAs), found on the surface of most cells in the body. These antigens help the immune system distinguish between "self" and "non-self" cells.

The goal of histocompatibility testing is to find a donor whose HLA markers closely match those of the recipient, reducing the risk of rejection of the transplanted organ or tissue. The test involves taking blood samples from both the donor and the recipient and analyzing them for the presence of specific HLA antigens using various laboratory techniques such as molecular typing or serological testing.

A high degree of histocompatibility between the donor and recipient is crucial to ensure the success of the transplantation procedure, minimize complications, and improve long-term outcomes.

Transplantation Immunology is a branch of medicine that deals with the immune responses occurring between a transplanted organ or tissue and the recipient's body. It involves understanding and managing the immune system's reaction to foreign tissue, which can lead to rejection of the transplanted organ. This field also studies the use of immunosuppressive drugs to prevent rejection and the potential risks and side effects associated with their use. The main goal of transplantation immunology is to find ways to promote the acceptance of transplanted tissue while minimizing the risk of infection and other complications.

Immunosuppression is a state in which the immune system's ability to mount an immune response is reduced, compromised or inhibited. This can be caused by certain medications (such as those used to prevent rejection of transplanted organs), diseases (like HIV/AIDS), or genetic disorders. As a result, the body becomes more susceptible to infections and cancer development. It's important to note that immunosuppression should not be confused with immunity, which refers to the body's ability to resist and fight off infections and diseases.

Stem cell transplantation is a medical procedure where stem cells, which are immature and unspecialized cells with the ability to differentiate into various specialized cell types, are introduced into a patient. The main purpose of this procedure is to restore the function of damaged or destroyed tissues or organs, particularly in conditions that affect the blood and immune systems, such as leukemia, lymphoma, aplastic anemia, and inherited metabolic disorders.

There are two primary types of stem cell transplantation: autologous and allogeneic. In autologous transplantation, the patient's own stem cells are collected, stored, and then reinfused back into their body after high-dose chemotherapy or radiation therapy to destroy the diseased cells. In allogeneic transplantation, stem cells are obtained from a donor (related or unrelated) whose human leukocyte antigen (HLA) type closely matches that of the recipient.

The process involves several steps: first, the patient undergoes conditioning therapy to suppress their immune system and make space for the new stem cells. Then, the harvested stem cells are infused into the patient's bloodstream, where they migrate to the bone marrow and begin to differentiate and produce new blood cells. This procedure requires close monitoring and supportive care to manage potential complications such as infections, graft-versus-host disease, and organ damage.

Postoperative complications refer to any unfavorable condition or event that occurs during the recovery period after a surgical procedure. These complications can vary in severity and may include, but are not limited to:

1. Infection: This can occur at the site of the incision or inside the body, such as pneumonia or urinary tract infection.
2. Bleeding: Excessive bleeding (hemorrhage) can lead to a drop in blood pressure and may require further surgical intervention.
3. Blood clots: These can form in the deep veins of the legs (deep vein thrombosis) and can potentially travel to the lungs (pulmonary embolism).
4. Wound dehiscence: This is when the surgical wound opens up, which can lead to infection and further complications.
5. Pulmonary issues: These include atelectasis (collapsed lung), pneumonia, or respiratory failure.
6. Cardiovascular problems: These include abnormal heart rhythms (arrhythmias), heart attack, or stroke.
7. Renal failure: This can occur due to various reasons such as dehydration, blood loss, or the use of certain medications.
8. Pain management issues: Inadequate pain control can lead to increased stress, anxiety, and decreased mobility.
9. Nausea and vomiting: These can be caused by anesthesia, opioid pain medication, or other factors.
10. Delirium: This is a state of confusion and disorientation that can occur in the elderly or those with certain medical conditions.

Prompt identification and management of these complications are crucial to ensure the best possible outcome for the patient.

"Pancreas-Kidney Transplantation: Drugs". pancreas-kidney.com. Archived from the original on 29 October 2013. a brief history of ... The drug is used primarily in liver and kidney transplantations, although in some clinics it is used in heart, lung, and heart/ ... They are used in the prophylaxis of the acute organ rejection after bilateral kidney transplantation, both being similarly ... Non-melanoma skin cancer (NMSC) after kidney transplantation is common and can result in significant morbidity and mortality. ...
The majority of pancreas transplantations (> 90%) are simultaneous pancreas-kidney transplantations. Complications immediately ... Simultaneous pancreas-kidney transplant (SPK), when the pancreas and kidney are transplanted simultaneously from the same ... Pancreas-after-kidney transplant (PAK), when a cadaveric, or deceased, donor pancreas transplant is performed after a previous ... This is the least performed method of pancreas transplantation and requires that only the pancreas of a donor is given to the ...
Thomas, Beje (16 May 2018). "Kidney-Pancreas Transplantation: Overview, Periprocedural Care, Technique". Medscape. "The C. ... History of Pancreas Transplantation". Transplantation of the Pancreas. Springer. pp. 45-46. ISBN 0-387-00589-7. Han, Duck Jong ... Lillehei led the world's first successful simultaneous pancreas-kidney transplant. It involved transplanting the whole pancreas ... On 17 December 1966, Lillehei assisted William Kelly transplant part of a pancreas and a whole kidney into a 28-year-old woman ...
... or pancreas-after-kidney) or a combined kidney-pancreas from a donor (SKP, simultaneous kidney-pancreas). Transplanting just ... Media related to Kidney transplantation at Wikimedia Commons Kidney transplantation at Curlie (Webarchive template wayback ... of kidney transplants within the first year of transplantation) presents as kidney rejection with associated kidney dysfunction ... Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with end-stage kidney disease (ESRD). ...
"Low incidence of BK virus nephropathy after simultaneous kidney pancreas transplantation". Transplantation. 82 (3): 382-8. doi: ... Typically, this is in the setting of kidney transplantation or multi-organ transplantation. Presentation in these ... The virus then disseminates to the kidneys and urinary tract where it persists for the life of the individual. It is thought ... of surveillance and rapid reduction in immunosuppression to control BK virus-related graft injury in kidney transplantation". ...
... kidney transplantation at the University of Cape Town; and in 2005, pancreas transplantation at the University of Minnesota ... and kidney transplantation in Tel Aviv; in 1991-1992, urologic oncology, reconstructive surgery, endourology and kidney ... Since 1997, he has headed the Centre for Urological Surgery, Dialysis and Kidney Transplantation at the Fundeni Clinical ... transplantation in Paris; in 1993-1994, urologic oncology, reconstructive surgery and kidney transplantation at Louisville, ...
Arrhythmia ablation and kidney transplantation were performed for the first time[when?] in Busan and South Gyeongsang province ... The clinical results for breast, colorectal, thyroid and pancreas surgeries are also notable. ...
Kirk is an American transplant surgeon and physician, specializing in kidney and pancreas transplantation. He is ... serving as the inaugural chief of the Transplantation Branch for the National Institute of Diabetes and Digestive and Kidney ... He was senior investigator and chief of the Transplantation Branch for the NIDDK from 2001 to 2007. During that time, he also ... He served as editor-in-chief for the American Journal of Transplantation from 2010 through 2020, and is now Editor Emeritus. ...
Pancreas, Kidney and Pancreas & Kidney simultaneously. Aside from patient care the clinic also plays an important role in ... The organ transplantation department of the clinic is one of the leading organ transplantation clinics in Germany. All ... clinically established forms of organ transplantation are implemented, e.g. Heart, Heart & Lung (simultaneously), Lungs (one or ...
Intestinal and Multivisceral Transplantation, Kidney and Pancreas Transplantation (translated into Spanish), Thyroidectomy: ... Molmenti, Ernesto P. (2015). Kidney and pancreas transplantation. Donald and Barbara Zucker School of Medicine at Hofstra/ ... Kidney & Pancreas Transplantation. Jaypee Brothers,Medical Publishers Pvt. Limited. ISBN 978-93-5152-339-0. Herman, Wendy. " ... Liver Transplantation, Pediatric Transplantation, Radiology, Surgery, and Transplantation. He also authored 8 books: Atlas of ...
In 2002 Hoffmann performed his first independent transplantations of kidney and pancreas. In 2003 he became specialist for ... Kidney Int 48:1563-1570, IF:7,91, 86 Cit. Inthorn D, Hoffmann JN, Hartl WH, Mühlbayer D, Jochum M (1997): Antithrombin III ... Hoffmannscientifi work is focussed on ischemia Reperfusion Injury, Sepsis, Transplantation, vascular access surgery, bypass ... evidence for elimination of immunomodulatory substances.Kidney Int. 1995 Nov;48(5):1563-70. Hoffmann JN, Vollmar B, Römisch J, ...
It is the only hospital in New Jersey approved to perform kidney, pancreas and liver transplants. The Lourdes Regional ... It began providing dialysis services in 1969 and began its organ transplantation program in 1974. ...
Transplantation of an entire pancreas (as an individual organ) is difficult and relatively uncommon. It is often performed in ... conjunction with liver or kidney transplant, although it can be done by itself. It is also possible to do a transplantation of ... Another improvement would be a transplantation of the pancreas or beta cell to avoid periodic insulin administration. This ... "Islet transplantation for brittle type 1 diabetes: the UIC protocol". American Journal of Transplantation. 8 (6): 1250-61. doi: ...
Common transplantations include kidneys, heart, liver, pancreas, intestines, lungs, bones, bone marrow, skin, and corneas. Some ... "Arterial Flow Regulator Enables Transplantation and Growth of Human Fetal Kidneys in Rats". American Journal of Transplantation ... When a recipient for a kidney or pancreas has no direct antibodies to the donor HLA the match is said to be a 0 ABDR mismatch ... These include Kidneys, Liver, Heart, Lungs, Pancreas and Intestine. Off late, uterus transplant has also been started in India ...
This is especially important for pancreas and kidney transplants. Due to the inherited nature of HLA genes, family members are ... Takemoto S, Port FK, Claas FH, Duquesnoy RJ (December 2004). "HLA matching for kidney transplantation". Human Immunology. 65 ( ... "The major histocompatibility complex in transplantation". Journal of Transplantation. 2012: 842141. doi:10.1155/2012/842141. ... The discovery of the MHC and role of histocompatibility in transplantation was a combined effort of many scientists in the 20th ...
In 1954 Joseph Murray, J. Hartwell Harrison and others accomplished the first kidney transplantation. Transplantations of other ... organs, such as heart, liver and pancreas, were also introduced during the later 20th century. The first partial face ...
The thyroid gland became the model for transplants of adrenal and parathyroid glands, pancreas, ovary, testicles and kidney. By ... Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era, edited by ... Overall postoperative complications after kidney transplantation occur in approximately 12% to 25% of kidney transplant ... "Results of Kidney Transplantation From Donors After Cardiac Death". Transplantation Proceedings. 42 (7): 2407-14. doi:10.1016/j ...
It may be used for the prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas ... Lohr, J.M; Oldstone, M.B.A (1990). "Detection of cytomegalovirus nucleic acid sequences in pancreas in type 2 diabetes". The ... a study by the European group for blood and marrow transplantation". Clin Infect Dis. 59 (4): 473-81. doi:10.1093/cid/ciu364. ... Transplantation. 100 (10): e74-e80. doi:10.1097/TP.0000000000001418. PMC 5030152. PMID 27495775. Erice, A. (1999). "Resistance ...
DNA Shows High Sensitivity for the Diagnosis of Pancreas Graft Rejection in Simultaneous Pancreas-kidney Transplantation. ... Transplantation. 2019:103(12):2657-2665. Sigdel TK, Acosta Archila F, Constantin T, et al. Optimizing Detection of Kidney ... Genetic Testing for Chronic Kidney Diseases: Clinical Utility and Barriers Perceived by Nephrologists. Kidney Medicine (2021) ... published correction appears in Transplantation. 2023 Jan 1;107(1):e43]. Transplantation. 2023;107(3):709-719. doi:10.1097/TP. ...
During his time at the MHH he was involved in 4,278 transplantations of liver, kidney and pancreas. Together with his wife Ina ... He is considered a pioneer in liver transplantation. The introduction of the term "transplantation medicine" goes back to ... Just one year later he was head of the Department of Special Surgery and Transplantation. In 1973, Pichlmayr finally became ... In 1988, Pichlmayr performed the world's first so-called split-liver transplantation, in which the donor liver was divided and ...
Avera is home to the region's longest standing kidney transplant program, established in 1993, in addition to pancreas and ... providing both allogeneic and autologous stem cell transplantation. Through its 300 locations, Avera contains various ...
He previously worked at Cedars-Sinai Medical Center, where he was Director of the Pancreas Transplantation, Kidney and Pancreas ... "Pancreas Transplant Director Donald Dafoe Joins Cedars-Sinai". Cedars-Sinai Medical Center press release via Newswise.com. May ... and Transplantation Science. Ex-husband to vascular surgeon Dr. Rhoda Dafoe and Sahara Dafoe, he is a father of five, and is ... where he is chief of transplantation surgery. ...
There were 108 kidney transplants, four combination kidney/pancreas transplants and no pancreas transplant performed during ... The Hospital Center's transplantation program ranks among the top five percent in the nation for patient outcomes and ... The program for kidney, pancreas and heart is one of the busiest in the mid-Atlantic region. Perhaps the Hospital Center's most ... Official website MedStar Health Organ Procurement and Transplantation Network 38°56′N 77°01′W / 38.93°N 77.02°W / 38.93; - ...
... pancreas and pancreatic islet cell transplantation and one of two sites for kidney transplantation in Scotland. In 2012, the ... "In Coming Days" The Edinburgh Royal Infirmary Souvenir Brochure 1942 "History of Kidney Transplantation". www.edren.org. ... Scotland's first combined kidney and pancreas transplant 2008 - Scotland's first live donor liver transplant by Murat Akyol and ... In 1960, the first successful kidney transplant performed in the UK was at this hospital. In 1964, the world's first coronary ...
Kidney: $62,000; Liver: $98,000-130,000; Liver+kidney: $160,000-180,000; Kidney+pancreas: $150,000; Lung: $150,000-170,000; ... As for the kidney transplantation, it may take one week to find a suitable donor, the maximum time being one month...If ... "kidney transplant technology was fully developed in China long before the persecution of Falun Gong began. Yet kidney ... the American Society of Transplantation and the Transplantation Society have called for sanctions on Chinese medical ...
... kidney, liver and pancreas transplants per year. The recipients of these organs are often patients who are indigent. Dr. Shires ... support and assist in the transplantation therapy of organs and tissues. Dana Shires was born in Coral Gables, Florida. His ... "dedicated to the recovery of life-saving and life-enhancing organs and tissue for transplantation therapy." As of 2001, ...
Four recipients were identified, two from Arizona (liver and kidney-pancreas), one from California (kidney), and another from ... two confirmed cases of Balamuthia transmission occurred through organ transplantation in December 2009 in Mississippi. Two ... "Balamuthia mandrillaris transmitted through organ transplantation --- Mississippi, 2009". Morbidity and Mortality Weekly Report ... kidney recipients, a 31-year-old woman and a 27-year-old man, suffered from post-transplant encephalitis due to Balamuthia. The ...
This is the most eminent award in the field of pancreas transplantation and transplantation of diabetic patients. Gruessner has ... He was the first surgeon to perform a combined laparoscopic removal of a portion of the pancreas and a kidney that were ... Gruessner has edited three standard textbooks including Transplantation of the Pancreas and Living Donor Organ Transplantation ... Gruessner was the first transplant surgeon to perform all types of abdominal transplants (kidney, liver, pancreas and intestine ...
... especially kidney, liver, pancreas, and heart transplantation. As multiple studies have demonstrated both its efficacy and ... "The role of Thymoglobulin induction in kidney transplantation: an update". Clinical Transplantation. 26 (5): E450-E464. doi: ... use of ALG for preserving short-term and long-term kidney function in patients immediately after human kidney transplantation. ... "Selection of induction therapy in kidney transplantation". Transplant International. 26 (7): 662-672. doi:10.1111/tri.12043. ...
The network manages the following centers: 93 units providing donors; 38 transplantation units (15 for kidney, 3 for kidney- ... pancreas, 9 for liver, 6 for heart, 4 for lungs and one for intestine) in 16 Hospitals; 5 regional coordinators and one from ... The main functions of CIR, which operates operating 24/7, are: managing waiting lists for patients awaiting transplantation; ...
Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single centers experience Transplantation. 2004 ... and simultaneous kidney-pancreas transplantation (SPKTx). Method: All pregnancies under tacrolimus after KTx or SPKTx from 1993 ... The aim of the present report is to examine the outcome of pregnancies under tacrolimus after kidney transplantation (KTx) ... 1 Thomas E. Starzl Transplantation Institute, UPMC Montefiore, Pittsburgh, PA, USA. [email protected] ...
Our transplant team performs more than 200 kidney transplants a year. We also perform between 10 and 20 pancreas transplants ... Our transplantation centre serves a population of almost two million people in North West London. ... We also provide transplant services for kidney patients from the Lister Hospital in Stevenage, a hospital in Gibraltar, and ... Meet the kidney and transplantation team * Patient information * Kidney and pancreas transplantation * Kidney transplantation ...
title = "C-peptide and combined kidney-pancreas transplantation",. keywords = "C-peptide, diabetes mellitus, kidney-pancreas, ... Bhargava R, Mitsides N, Saif I, MacDowall P, Woywodt A. C-peptide and combined kidney-pancreas transplantation. NDT Plus. 2009 ... C-peptide and combined kidney-pancreas transplantation. / Bhargava, Ramya; Mitsides, Nicos; Saif, Imran et al. In: NDT Plus, ... Bhargava, R, Mitsides, N, Saif, I, MacDowall, P & Woywodt, A 2009, C-peptide and combined kidney-pancreas transplantation, ...
Left kidney recipient. Immune. Not detected. Not detected. Detected. Vaccinated. Right kidney recipient. Immune. Not detected. ... Transmission of Hepatitis A Virus through Combined Liver-Small Intestine-Pancreas Transplantation Monique A. Foster. , Lauren M ... Transmission of Hepatitis A Virus through Combined Liver-Small Intestine-Pancreas Transplantation. ...
We report herein a case of mesangial sclerosis in a patient who underwent successful kidney-pancreas transplantation despite ... pancreas-kidney transplantation is considered a curative treatment for type 1 diabetes complicated by end-stage kidney disease ... function.Case presentationA 76-year-old type 1 diabetic man who underwent a simultaneous pancreas-kidney transplantation 19 ... resembling diabetic nephropathy in a patient with good glucose control after simultaneous pancreas-kidney transplantation with ...
The first successful pancreas transplantation in conjunction with a simultaneous kidney transplantation was performed by W. ... The purpose of pancreas transplantation is to ameliorate type I diabetes and produce complete insulin independence. ... Pancreas transplantations are also performed after successful kidney transplantation (ie, pancreas-after-kidney [PAK] ... An evidence-based analysis of simultaneous pancreas-kidney and pancreas transplantation alone. Am J Transplant. 2005 Nov. 5(11 ...
Background The purpose of pancreas transplantation is to ameliorate insulin-dependent type 1 diabetes and produce complete ... Kidney transplantation in diabetic patients undergoing combined kidney-pancreas or kidney-only transplantation. Transplantation ... encoded search term (Kidney-Pancreas Transplantation) and Kidney-Pancreas Transplantation What to Read Next on Medscape ... When the pancreas transplantation is performed simultaneously with kidney transplantation, it is not uncommon for the kidney ...
Division of Kidney & Pancreas Transplantation. 912 Oxford House. 1313 21st Avenue South. Nashville, TN 37232-4750. Phone: (615 ... The Vanderbilt Adult Kidney and Pancreas Transplant Program received the HRSA/Organ Donation and Transplantation Alliance ... "Pretransplant Overweight and Obesity Do Not Affect Physical Quality of Life After Kidney Transplantation," in the Journal of ... Deonna Moore, NP, presented "Living Kidney Donor Evaluation and Factors Leading to Non-Donation" at the UNOS Tranplant ...
Read chapter CASE 11 of Molmentis Kidney and Pancreas Transplantation: Operative Techniques and Medical Management, 2e online ... Ernesto Pompeo Molmenti.eds. Molmentis Kidney and Pancreas Transplantation: Operative Techniques and Medical Management, 2e. ... Ernesto Pompeo Molmenti. Molmentis Kidney and Pancreas Transplantation: Operative Techniques and Medical Management, 2e. ... Home Books Molmentis Kidney and Pancreas Transplantation: Operative Techniques and Medical Management, 2e ...
"Use of OKT3 in kidney, pancreas, and liver transplantation." Transplant Proc, vol. 22, no. 4, Aug. 1990, pp. 1748-49. ... "Use of OKT3 in kidney, pancreas, and liver transplantation." Transplant Proc 22, no. 4 (August 1990): 1748-49. ... Use of OKT3 in kidney, pancreas, and liver transplantation.. Publication , Journal Article ... Use of OKT3 in kidney, pancreas, and liver transplantation. Transplant Proc. 1990 Aug;22(4):1748-9. ...
Kidney transplantation is the treatment of choice for most patients with end-stage renal disease, and pancreas transplantation ...
Pancreas transplants give the person a chance to stop taking insulin injections. ... Pancreas transplants give the person a chance to stop taking insulin injections. ... A pancreas transplant is surgery to implant a healthy pancreas from a donor into a person with diabetes. ... A pancreas transplant is surgery to implant a healthy pancreas from a donor into a person with diabetes. ...
Kidneys, Liver, Pancreas, and Lungs). The US market for Organ and Tissue Transplantation in this report is analyzed by the ... Heart Valves Transplantation. II. EXECUTIVE SUMMARY 1. MARKET OVERVIEW 2. MARKET TRENDS 3. TECHNOLOGICAL INNOVATIONS 4. MAJOR ... The global and regional markets (except the US) for Organ and Tissue Transplantation in this report are analyzed by the ... following Product Segments: Organ Type (Heart, Kidneys, Liver, Pancreas, Lungs, and Intestine), Tissue Type (Cornea, Heart ...
... located in New York City offers a wide range of transplantation services, including procedures related to the bone marrow, ... Kidney & Pancreas Transplantation Mount Sinai utilizes a multi-disciplinary approach to ensure a seamless patient journey for ... Living Donor Transplantation Living donation offers another option for some liver and kidney transplant candidates. Learn how ... Liver Transplantation As one of the largest liver transplantation centers in the nation, Mount Sinais surgeons treat adult and ...
Combined Kidney and Pancreas Transplantation Marilyn Rossman Bartucci, MSN, RN, CS, CCTC Marilyn Rossman Bartucci, MSN, RN, CS ... Combined kidney and pancreas transplantation is a safe and effective treatment option for diabetic nephropathy. During the past ... Successful outcomes of Kidney and pancreas transplantation are due in large part to careful nursing assessment, diagnosis, ... Marilyn Rossman Bartucci; Combined Kidney and Pancreas Transplantation. AACN Adv Crit Care 1 February 1995; 6 (1): 143-152. doi ...
Contact the organ transplantation programs at NewYork-Presbyterian. ...
The majority of pancreas transplantations (> 90%) are simultaneous pancreas-kidney transplantations. Complications immediately ... Simultaneous pancreas-kidney transplant (SPK), when the pancreas and kidney are transplanted simultaneously from the same ... Pancreas-after-kidney transplant (PAK), when a cadaveric, or deceased, donor pancreas transplant is performed after a previous ... This is the least performed method of pancreas transplantation and requires that only the pancreas of a donor is given to the ...
... randomized pilot study comparing cyclosporine versus tacrolimus in simultaneous pancreas-kidney transplantation. BOGGI, UGO; ... is the calcineurin inhibitor usually employed in simultaneous pancreas-kidney transplantation (SPKTx), no prospective ... is the calcineurin inhibitor usually employed in simultaneous pancreas-kidney transplantation (SPKTx), no prospective ... All pancreata were drained into the portal vein. RESULTS: After a median follow-up of 15.6 months, six kidney acute rejection ...
Thus, the full impact of islet/pancreas transplantation (alone or after kidney) on QoL is unknown. Furthermore, no studies have ... Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: a ... or pancreas after kidney (PAK). Methods We used a Population, Intervention, Comparisons, Outcomes (PICO) strategy to search ... Results Twelve studies [including PRO assessment of PAK, PTA, islet-after kidney (IAK) and islet transplant alone (ITA); n = 7- ...
T1 - Comparison before and after transplantation of pancreas-kidney and pancreas-kidney with loss of pancreas--a prospective ... N2 - Comparison before and after transplantation of pancreas-kidney and pancreas-kidney with loss of pancreas--a prospective ... AB - Comparison before and after transplantation of pancreas-kidney and pancreas-kidney with loss of pancreas--a prospective ... Comparison before and after transplantation of pancreas-kidney and pancreas-kidney with loss of pancreas--a prospective ...
The ipsilateral group also demonstrated a trend to improved survival of patient, pancreas, and kidney graft, at 1- and 5-year ... placement of both organs on the same side raises concerns that the pancreas graft might compromise the distally placed kidney. ... MATERIAL AND METHODS:In a single unit, 67 SPK transplantations (cSPK n=49, iSPK n=18) were performed from 2008 to 2011. The ... It is routine to implant the pancreas on the right and the renal graft on the left iliac fossa during a simultaneous kidney and ...
Dive into the research topics of A pilot study of immunosuppression minimization after pancreas-kidney transplantation ... A pilot study of immunosuppression minimization after pancreas-kidney transplantation utilizing thymoglobulin induction and ... A pilot study of immunosuppression minimization after pancreas-kidney transplantation utilizing thymoglobulin induction and ... A pilot study of immunosuppression minimization after pancreas-kidney transplantation utilizing thymoglobulin induction and ...
... significant coronary disease and inform decision making with regard to coronary revascularization prior to transplantation. In ... Cardiovascular disease is the leading cause of death in simultaneous pancreas kidney transplantation (SPKT) patients. SPKT is ... Kidney Transplantation, Male, Middle Aged, Myocardial Perfusion Imaging, Pancreas Transplantation, Retrospective Studies, Risk ... Cardiovascular disease is the leading cause of death in simultaneous pancreas kidney transplantation (SPKT) patients. SPKT is ...
Following Simultaneous Pancreas - Kidney Transplantation. N. Sarabu, J. Augustine, K. Woodside, D. Hricik, A. Padiyar, E. ... filtration-rate-egfr-and-iothalamate-measured-gfr-mgfr-following-simultaneous-pancreas-kidney-transplantation/. Accessed ... Objective: Creatinine based eGFR equations may overestimate the true GFR in simulataneous pancreas-kidney (SPK) transplant ... American Journal of Transplantation. The official publication for the American Society of Transplantation (AST) and the ...
Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up ... Relationship between lipid profiles and kidney function in patients with type 1 diabetes Authors (first, second and last of 11) ... Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical ...
... kidney, pancreas and liver transplantation (69.5%); and general surgery (48.7%) in 2010. Heart and lung transplantation ... such as transplantation. Additional research is needed to understand the types of care delivered through patient portals and to ... interaction done through secure messaging increased for all specialties and was highest for heart and lung transplantation ( ...
... up-to-date book published on the topic of Kidney and Pancreas Transplantation. It examines the... ... Dhiresh Kumar Maharjan- Minimal Invasive Hepatobiliary and Pancreas Surgery. *KS Narayan Reddy- The Essentials of Forensic ... Kidney and Pancreas Transplantation Author Ernesto Pompeo Molmenti Rs. 9750 Qty:. Text in the book is intended to be the most ...
LD kidney transplantation (LDKT) is preferred over DD kidney transplantation (DDKT), because of superior quality kidneys that ... is the preferred kidney replacement therapy (KRT) for suitable patients with end-stage kidney disease (ESKD)1. Donor kidneys ... and the possibility for kidney exchange7 including chains initiated by unspecified donors8. Perhaps the most important ... result in improved patient and graft survival2, greater flexibility for transplantation across the ABO3,4 and HLA5,6 barriers, ...
... a successful pancreas transplant can improve health issues caused by type 1 diabetes. Learn more. ... Simultaneous kidney-pancreas transplant. One of the most serious complications of type 1 diabetes is end-stage kidney disease, ... pancreas transplantation may be an option. By restoring insulin production, a successful pancreas transplant can help patients: ... Patients can undergo pancreas transplant six months to a year after a kidney transplant if a pancreas becomes available. ...
Join the Lone Kidney Club: incentivising live organ donation. Annet Glas, Journal of Medical Ethics, 2020 ... Pancreas transplantation. Patrick G Dean et al., BMJ, 2017. *Ethics, organ donation and tax: a proposal. Thomas Søbirk Petersen ... Individual readiness for transplantation medicine of laypersons and the number of deceased organ donors: a cross-sectional ...
  • Our transplant team performs more than 200 kidney transplants a year. (imperial.nhs.uk)
  • We also perform between 10 and 20 pancreas transplants each year. (imperial.nhs.uk)
  • The number of pancreas transplants in the United States decreased from 2004 (when approximately 1500 were performed) to 2015. (medscape.com)
  • Subsequently, pancreas transplants have risen, mainly because of increased simultaneous pancreas-kidney (SPK) transplants, while pancreas transplant alone (PTA) continued on a downward trend. (medscape.com)
  • PAK represented less than 10% of pancreas transplants in 2019. (medscape.com)
  • 1043 pancreas transplants were performed in 2012. (medscape.com)
  • However, the percentage of pancreas transplants performed as part of a multi-organ transplant has increased since 2004. (medscape.com)
  • David Shaffer, M.D., presented the division's experience with "Antibody Desensitization using IVIG in Living Donor Kidney Transplants with a Positive T-Cell Crossmatch," at the ASTS 10th Annual State-of-the-Art Winter Symposium. (vumc.org)
  • Pancreas transplants give the person a chance to stop taking insulin injections. (medlineplus.gov)
  • During the past decade, pancreas transplants had improved outcomes as a result of improvements in pancreas recovery and preservation, the surgical procedure, immunosuppressive regimens, and immunologic monitoring. (aacnjournals.org)
  • Between April 2021 and March 2022, only 40% of adult kidney only transplants were from LDs ( 22 ) and only 35% of these transplants were pre-emptive ( 24 ). (frontiersin.org)
  • In comparison, 50% of kidney transplants in the Netherlands in 2021 were from LDs and a greater proportion of these patients (44%) were pre-emptive ( 25 ). (frontiersin.org)
  • Pancreas transplants aren't recommended for patients who can manage their diabetes through diet, medication and other means, since the procedure carries all the risks and recovery issues of major surgery, as well as the possibility that the body's immune system will reject the transplanted organ. (ucsfhealth.org)
  • Patients with type 1 diabetes may be evaluated for pancreas transplants or combined kidney-pancreas transplants. (ucsfhealth.org)
  • Successful combined kidney-pancreas transplants prevent diabetes from damaging transplanted kidneys and eliminate the need for insulin therapy. (ucsfhealth.org)
  • Improvements in surgical techniques and immunosuppressive medications have made it possible to perform pancreas transplants in diabetic patients who don't yet have serious kidney disease but who have problems maintaining normal blood sugar and insulin levels. (ucsfhealth.org)
  • With these improvements, people who receive pancreas transplants alone are achieving the same excellent results as those who get simultaneous kidney-pancreas transplants. (ucsfhealth.org)
  • All kidney-pancreas transplants at Emory are performed using organs from deceased donors. (emoryhealthcare.org)
  • We perform both live-related and cadaveric transplants, as well as multi-organ transplants (kidney- pancreas/kidney-liver). (apollohospitals.com)
  • Since 2008, we have performed over 200 kidney paired donation transplants by working with the National Kidney Registry. (weillcornell.org)
  • Few medical centers have performed kidney transplants on kids for more than half a century. (uwhealth.org)
  • Dr. Sibulesky specializes in liver, kidney and kidney-pancreas transplants. (uwmedicine.org)
  • The majority of transplants occur in high income countries, while in some parts of the world kidney transplantation is even non-existent or only relies on live donation. (who.int)
  • Toronto (February 16, 2022) - A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. (eurekalert.org)
  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 0 0. (cdc.gov)
  • Studies comparing renal function in SPK transplantation recipients versus diabetic KTA recipients did not demonstrate significant differences during the early posttransplant period. (medscape.com)
  • Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys. (annalsoftransplantation.com)
  • To determine outcomes utilizing thymoglobulin and sirolimus immunosuppression, with early steroid withdrawal in low-immune responder pancreas-kidney (SPK) recipients, and conversion from cyclosporine (CsA) to mycophenolic acid (MPA) in all recipients at 6 months posttransplantation. (houstonmethodist.org)
  • Thymoglobulin induction with sirolimus maintenance therapy permitted immunosuppression minimization in selected pancreas transplant recipients. (houstonmethodist.org)
  • The United Network for Organ Sharing (UNOS) provides a toll-free patient services line to help transplant candidates, recipients, and family members understand organ allocation practices and transplantation data. (emoryhealthcare.org)
  • Outcomes Among Undocumented Immigrant Kidney Transplant Recipients in California. (doximity.com)
  • Intraoperative Near-Infrared Spectroscopy Monitoring of Renal Allograft Reperfusion in Kidney Transplant Recipients: A Feasibility and Proof-of-Concept Study. (doximity.com)
  • Current Pharmacological Intervention and Medical Management for Diabetic Kidney Transplant Recipients. (doximity.com)
  • We also specialize in complex renal transplantation, such as sensitized recipients and across blood groups. (apollohospitals.com)
  • Researchers from the Scientific Registry of Transplant Recipients (SRTR) and UNOS' departments of Research and Policy collaborated to publish two special articles in the December 2012 issue of the American Journal of Transplantation . (unos.org)
  • People interested in participating in Kidney Paired Donation (whether donors or recipients, incompatible or compatible) are entered into a Kidney Paired Donation database. (weillcornell.org)
  • Sophisticated computer software designed to match up donors and recipients within a Kidney Paired Donation registry is run on a regular basis, usually anywhere from daily, to once per week to once per month, depending on the number of donors and recipients entered into the registry since the prior run. (weillcornell.org)
  • This is an area where entry of compatible donor/recipient pairs into Kidney Paired Donation registries may be beneficial since this could free up some 'O' donors for 'O' recipients. (weillcornell.org)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • We have served living kidney donors and pediatric recipients for more than 50 years. (uwhealth.org)
  • Investigation included review of laboratory data and medical in liver recipients after transplantation that were reported to records. (cdc.gov)
  • Recipients of a the Advisory Committee on Immunization liver from a donor with isolated total anti-HBc positive results can develop reactivation of hepatitis B after transplantation. (cdc.gov)
  • The hazard that transplantation presents for live organ donors is the inequities that occur when vulnerable and poor people are de donors, and the recipients are from high income backgrounds. (who.int)
  • The group included 78 kidney-transplant recipients, 12 liver-transplant recipients, 8 lung-transplant or heart-transplant recipients, and 3 pancreas-transplant recipients. (cdc.gov)
  • An alternative therapy that may also ameliorate diabetes is islet cell transplantation. (medscape.com)
  • Pancreas and islet cell transplantation can be considered complementary transplant options and undergoing one or the other is not mutually exclusive. (medscape.com)
  • In an analysis of 40 pancreas transplantations (50% PTA, 27.5% SPK, 22.5% PAK) after islet cell transplantation graft failure, overall survival rates (97% at 1 year and 83% at 5 years) were not adversely affected. (medscape.com)
  • An alternative therapy that may also ameliorate diabetes is islet cell transplantation, but this procedure is experimental and has not yet demonstrated equivalence to whole-graft pancreas transplantation. (medscape.com)
  • Aims For selected individuals with complex Type 1 diabetes, pancreatic islet transplantation (IT) offers the potential of excellent glycaemic control without significant hypoglycaemia, balanced by the need for ongoing systemic immunosuppression. (ncl.ac.uk)
  • Thus, the full impact of islet/pancreas transplantation (alone or after kidney) on QoL is unknown. (ncl.ac.uk)
  • Pancreatic Islet Cell Transplantation Pancreatic islet cell transplantation is the surgical removal of the pancreas from a recently deceased person, the separation of islet cells from the pancreas, and then their injection into. (msdmanuals.com)
  • The complications of graft pancreatitis and bladder leakage that plagued early experiences with pancreas transplantation have largely been resolved as a result of both better technical expertise and fewer rejection- and immunosuppression-related complications. (medscape.com)
  • Thus, normalizing glucose through successful pancreas transplantation might be expected to stabilize or reverse microvascular complications. (medscape.com)
  • One of the most serious complications of type 1 diabetes is end-stage kidney disease, which may require a kidney transplant. (ucsfhealth.org)
  • Proper control of diabetes and blood pressure, together with certain medications may prevent the onset of kidney complications or reduce further kidney damage if that has already occurred. (nkf.org.my)
  • Kidney disease, one of the most serious complications of diabetes, causes at least a third of patients with type 1 diabetes to experience kidney failure within 20 to 30 years after the onset of their disease. (emoryhealthcare.org)
  • In addition toallograft rejection (a topic covered elsewhere in this series), a multitude of medical complications mark the post-transplantation course. (ersjournals.com)
  • Despite insulin injection treatment, diabetic patients suffer from long-term complications, such as blindness and kidney failure. (lu.se)
  • LD kidney transplantation (LDKT) is preferred over DD kidney transplantation (DDKT), because of superior quality kidneys that result in improved patient and graft survival ( 2 ), greater flexibility for transplantation across the ABO ( 3 , 4 ) and HLA ( 5 , 6 ) barriers, and the possibility for kidney exchange ( 7 ) including chains initiated by unspecified donors ( 8 ). (frontiersin.org)
  • Human donor lungs not suitable for transplantation from type A donors were put in the EVLP circuit. (eurekalert.org)
  • We are committed to working with HRSA, Congress, the wider donation and transplantation community and other stakeholders to ensure the best possible system for patients, donors and their families. (unos.org)
  • Our membership in the National Kidney Registry increases access to kidneys from living donors so your child gets a better kidney sooner, which is especially important if your child is highly sensitized. (uwhealth.org)
  • She is interested in both clinical and translational research in liver transplantation and the mechanism of biliary strictures in donors. (uwmedicine.org)
  • Donors Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
  • The global and regional markets (except the US) for 'Organ and Tissue Transplantation' in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, and Lungs). (prnewswire.com)
  • Tarleton's doctors noted that most transplanted organs - including kidneys, lungs, and hearts - have limited life span. (bostonglobe.com)
  • These include earlier exposure to the risks of immunosuppression and transplantation surgery ( 19 , 20 ), potential earlier loss of residual native kidney function and higher risk of non-adherence to immunosuppressants due to not having experienced the morbidity of dialysis ( 12 ). (frontiersin.org)
  • Our research on immunosuppression, including 'prednisone-free,' is greatly improving the way kids live with their new kidney. (uwhealth.org)
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 0 0. (cdc.gov)
  • A pancreas transplant is surgery to implant a healthy pancreas from a donor into a person with diabetes. (medlineplus.gov)
  • The healthy pancreas is taken from a donor who is brain dead, but is still on life support. (medlineplus.gov)
  • The healthy pancreas is transported in a cooled solution that preserves the organ for up to about 20 hours. (medlineplus.gov)
  • PKT-P). A standardized home-based interview is done during dialysis, and repeated 5, 12, and 18 months after transplantation in both groups by the same interviewer. (maastrichtuniversity.nl)
  • Kidney-pancreas transplant is a possible treatment option for patients with insulin-dependent diabetes who are on, or close to requiring, dialysis. (emoryhealthcare.org)
  • Hemodialysis - Hemodialysis is the standard treatment for patients with kidney failure, and we have a well-maintained 27-station dialysis unit for this purpose. (apollohospitals.com)
  • Some kids must be on dialysis while waiting for their kidney transplant. (uwhealth.org)
  • Even in LMIC, kidney transplantation is also cost-effective compared with renal replacement therapy with dialysis. (who.int)
  • Pancreas transplantation is principally performed to ameliorate type 1 diabetes mellitus and produce complete independence from injected insulin. (medscape.com)
  • Despite extensive animal experimentation, pancreatic transplantation did not become a reality until 1966, when W.D. Kelly performed the first human, whole-organ pancreatic transplantation to treat type 1 diabetes mellitus. (medscape.com)
  • Most pancreatic transplantations are performed in patients with type 1 diabetes mellitus, who lack of insulin production. (medscape.com)
  • The aim of the present report is to examine the outcome of pregnancies under tacrolimus after kidney transplantation (KTx) and simultaneous kidney-pancreas transplantation (SPKTx). (nih.gov)
  • Subsequent experimentation with intrasplenic transplantation did not succeed because of graft necrosis. (medscape.com)
  • [ 2 ] The first successful pancreas transplantation was performed in 1966, simultaneously with kidney graft. (medscape.com)
  • Recurrent diabetic nephropathy is observed as early as 2 years after KTA in a diabetic recipient or upon failure of the pancreas graft after SPK but has never been reported with a functioning SPK. (medscape.com)
  • The objectives of this study are to evaluate QoL before and after PKT and to compare the results with patients in whom the pancreas graft failed soon after the transplantation (PKT-P). The trial is a prospective controlled multicenter study. (maastrichtuniversity.nl)
  • The introduction of TAC in 1990 improved actuarial graft and patient survival rates following all types of intestine transplantation. (medscape.com)
  • These results were compared to eGFR values obtained using three different commonly used equations, namely, Modified Diet in Renal Disease (MDRD), Cockroft-Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). (atcmeetingabstracts.com)
  • In fact, some people with chronic kidney disease do not have any symptoms in the initial stages. (nkf.org.my)
  • Novel therapeutic approaches for COVID-19 in chronic kidney disease and transplant. (doximity.com)
  • Hemodiafiltration (HDF) - Hemodiafiltration (HDF) is the state-of-the-art treatment for patients with chronic kidney disease and is the preferred modality of treatment in advanced countries worldwide. (apollohospitals.com)
  • When health-care systems face this severe situation that affects all, from high to LMIC, they find it increasingly difficult to respond to the ever growing incidence of Chronic Kidney Disease (CKD) and the costs of its derived consequences. (who.int)
  • 3 Global Observatory on Donation and Transplantation 2016. (who.int)
  • Lung transplantation can prolong and dramatically improve the quality of life for patients with advanced lung diseases. (mountsinai.org)
  • Having universal organs means we could eliminate the blood-matching barrier and prioritize patients by medical urgency, saving more lives and wasting less organs," adds Dr. Cypel, who is also a Thoracic Surgeon at UHN's Sprott Department of Surgery, a Professor in the Department of Surgery at U of T and the Canada Research Chair in Lung Transplantation. (eurekalert.org)
  • One article concentrated on kidney, pancreas and liver allocation, and the other examined lung and heart allocation. (unos.org)
  • Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
  • Initial attempts to perform lung transplantation (LTx) were marred by technical limitations that often resulted in early postoperative death. (ersjournals.com)
  • Nevertheless, the proportions decreased depending on the type of organ, i.e. liver (72.5%), heart (66.1%), lung (43.9%), pancreas (27.8%) and small bowel (14.9%)4. (who.int)
  • SARS-CoV-2 infection in two patients following recent lung transplantation. (cdc.gov)
  • We report herein a case of mesangial sclerosis in a patient who underwent successful kidney-pancreas transplantation despite well-controlled glucose and excellent pancreatic allograft function. (escholarship.org)
  • Kidney allograft biopsy was performed to evaluate proteinuria and showed diffuse capillary loop thickening and diffuse moderate to severe mesangial sclerosis resembling diabetic nephropathy. (escholarship.org)
  • This case demonstrates a case of mesangial sclerosis resembling diabetic nephropathy in a patient with good glucose control after simultaneous pancreas-kidney transplantation with excellent pancreatic allograft function. (escholarship.org)
  • Kidney allograft infarction associated with transplant renal artery stenosis in a COVID-19 kidney transplant recipient. (doximity.com)
  • http://www.researchandmarkets.com/research/f7thqr/organ_and_tissue ) has announced the addition of the "Organ and Tissue Transplantation - Global Strategic Business Report" report to their offering. (prnewswire.com)
  • This report analyzes the worldwide markets for Organ and Tissue Transplantation in Number of Procedures. (prnewswire.com)
  • 4 World Health Assembly - Resolution WHA63.22 on Human organ and tissue transplantation, May 2010. (who.int)
  • The Vanderbilt Adult Kidney and Pancreas Transplant Program received the HRSA/Organ Donation and Transplantation Alliance Bronze Award at the 6th National Learning Congress for the Donation and Transplantation Community of Practice. (vumc.org)
  • With a long track record of outstanding outcomes and short wait times, our team of UW Health Kids Kidney Transplant surgeons and specialists are here for your child. (uwhealth.org)
  • Organ donation is the process of taking healthy organs and tissues from one person for transplantation into another. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • Diabetes mellitus is a disorder where the pancreas does not make enough insulin or the insulin is not effective. (nkf.org.my)
  • Diabetes mellitus is a disease in which the pancreas produces little or no insulin, or the pancreas makes insulin but the body is unable to use that insulin properly. (emoryhealthcare.org)
  • over 26,000 SPK transplantations were performed from 1988 through 2021. (medscape.com)
  • No pancreas rejection episode was recorded. (unipi.it)
  • With a mean follow-up of 9 ± 4 months, one pancreas was lost to pancreatitis, with no patient or kidney losses and no acute rejection episodes. (houstonmethodist.org)
  • You will also have your blood tested against the donor to make sure you are not sensitized against this donor, a situation which would result in rejection of the kidney and pancreas. (emoryhealthcare.org)
  • Tzvetanov I, Spaggiari M, Jeon H, Roca RG, Bhati C, Oberholzer J, Benedetti E.&The role of splenectomy in the setting of refractory humoral rejection after kidney transplantation. (uic.edu)
  • The combined company's pipeline would also include thymus, pancreas, and kidney regeneration, in addition to the existing AgeX assets, including UniverCyteâ„¢, which uses the HLA-G gene to potentially confer low immune observability to cells to suppress rejection of transplanted cells. (businesswire.com)
  • If you receive a kidney transplant without a pancreas transplant, you must continue to take insulin in addition to immunosupressive medications to protect the new kidney. (ucsfhealth.org)
  • Overall, more than 90% of people who receive a pancreas transplant receive a kidney transplant at the same time. (msdmanuals.com)
  • Most pancreas transplantation candidates have had diabetes for 20-25 years on average prior to consideration for transplantation, so many have had laser surgery for retinopathy. (medscape.com)
  • Studies suggest, however, that retinopathy may improve 3 years after SPK and that the need for further laser surgery is less after SPK than kidney transplantation alone (KTA). (medscape.com)
  • Victor Zaydfudim, M.D., general surgery resident, was lead author of "Pretransplant Overweight and Obesity Do Not Affect Physical Quality of Life After Kidney Transplantation," in the Journal of the American College of Surgeons. (vumc.org)
  • The surgery for a pancreas transplant takes about 3 hours. (medlineplus.gov)
  • However, because of the risks involved with surgery, most people with type 1 diabetes do not have a pancreas transplant shortly after they are diagnosed. (medlineplus.gov)
  • The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. (atcmeetingabstracts.com)
  • Your success as a pancreas transplant recipient depends in part on your understanding of what to expect before, during, and after your transplant surgery. (emoryhealthcare.org)
  • Join Dr. Parsia Vagefi, Chief of Surgical Transplantation, and Dr. Steven Hanish, Surgical Director of Liver Transplantation, as they grant unprecedented access to the OR while performing a liver transplant surgery. (utsouthwestern.edu)
  • Go inside the OR with Dr. Parsia Vagefi, chief of the Division of Surgical Transplantation, to experience a kidney transplant surgery. (utsouthwestern.edu)
  • Successful pancreas transplant surgery has resulted in high patient satisfaction as well as approval from the many referring physicians who are pleased with the well-designed transplant program. (uhhospitals.org)
  • Dr. Sibulesky has clinical expertise in liver transplantation, kidney-pancreas transplantation and surgery. (uwmedicine.org)
  • Dr. Matthew Cooper is a professor of surgery at Georgetown School of Medicine, and director of kidney and pancreas transplantation and director for quality at the Medstar Georgetown Transplant Institute (MGTI). (scrantonchamber.com)
  • There are so many unknowns and so many new things we are discovering,'' said Dr. Bohdan Pomahac, director of plastic surgery transplantation at the Brigham and one of Tarleton's surgeons. (bostonglobe.com)
  • requires abdominal surgery and the use of immunosuppressants afterward, so transplanting a pancreas at the same time adds few risks. (msdmanuals.com)
  • [ 2 ] Nevertheless, extended survival was seen in a few patients and included a 3-year-old girl who received a multivisceral transplant (stomach, duodenum, pancreas, small bowel, colon and liver). (medscape.com)
  • [ 9 ] The use of TAC as the primary immunosuppressant in small bowel transplantation as well as improved surgical techniques, the availability of an increased array of potent immunosuppressive medications, infection prophylaxis, and suitable patient selection have contributed to the reality of this procedure for a growing number of patients who are total parenteral nutrition (TPN)-dependent and have permanent intestinal failure. (medscape.com)
  • Mount Sinai Transplant offers a wide range of transplantation services, including procedures related to the bone marrow , cornea , heart , intestinal , kidney , liver , and pancreas . (mountsinai.org)
  • In addition, pancreas transplantation in patients with type 2 diabetes has increased steadily in recent years. (medscape.com)
  • Patients with type 2 diabetes are less likely to be candidates because they may be insulin-resistant, meaning their body's cells don't respond normally to insulin, and wouldn't reap the benefits of a pancreas transplant. (ucsfhealth.org)
  • About 100 transplant centers in the United States perform pancreas transplantations. (medscape.com)
  • BACKGROUND: Although tacrolimus (Prograf) is the calcineurin inhibitor usually employed in simultaneous pancreas-kidney transplantation (SPKTx), no prospective randomized studies have compared its efficacy to cyclosporine (Neoral), when either drug is used in combination with mycophenolate mofetil (MMF) and the pancreas is drained into the portal vein. (unipi.it)
  • [ 1 ] In 2020, 135 PTAs were performed in the US, compared with 827 SPK transplantations. (medscape.com)
  • Although Chris joined One Lambda full time in March 2020, he remains an active clinician with current licensing and continues to undertake outpatient clinics and kidney biopsies. (thermofisher.com)
  • Transplant infectious disease : an official journal of the Transplantation Society 2020 12 0. (cdc.gov)
  • Cite this: Intestine Transplantation - Medscape - Jun 01, 2002. (medscape.com)
  • The shortage of available organs for transplantation and unequal access to transplantation have also stimulated the emergence of trafficking in persons for the purpose of the removal of organs and trafficking in human organs, frequently as transnational criminal activities. (who.int)
  • The aim of combined pancreas-kidney transplantation (PKT) in type I diabetic patients with end-stage nephropathy is to restore both functions. (maastrichtuniversity.nl)
  • abstract = "Comparison before and after transplantation of pancreas-kidney and pancreas-kidney with loss of pancreas--a prospective controlled quality of life study.Adang EM, Engel GL, van Hooff JP, Kootstra G.University Hospital, Maastricht, The Netherlands.The aim of combined pancreas-kidney transplantation (PKT) in type I diabetic patients with end-stage nephropathy is to restore both functions. (maastrichtuniversity.nl)
  • Therefore, a central goal of diabetes research is to generate large numbers of functional beta cells for transplantation into diabetic patients. (lu.se)
  • The most common multi-organ transplant was kidney-pancreas transplant. (medscape.com)
  • Simultaneous pancreas-kidney transplantation is considered a curative treatment for type 1 diabetes complicated by end-stage kidney disease. (escholarship.org)
  • This operation is usually done at the same time as a kidney transplant in diabetic people with kidney disease. (medlineplus.gov)
  • It is used in the treatment of autoimmune diseases (for example rheumatoid arthritis or Behcet's Disease) and in transplantations. (wikipedia.org)
  • The interview consisted of disease-specific questions (RSCL), general questionnaires (NHP I and II, ABS), the Visual Analogue Scale, a specific questionnaire (Anxiety), and evaluative questions about social support and transplantation. (maastrichtuniversity.nl)
  • Cardiovascular disease is the leading cause of death in simultaneous pancreas kidney transplantation (SPKT) patients. (ox.ac.uk)
  • Traditionally, invasive angiography has been used as a tool to diagnose significant coronary disease and inform decision making with regard to coronary revascularization prior to transplantation. (ox.ac.uk)
  • Kidney transplantation (KT) is the preferred kidney replacement therapy (KRT) for suitable patients with end-stage kidney disease (ESKD) ( 1 ). (frontiersin.org)
  • When kidney disease develops over a short period of time it's called Acute Kidney Failure. (nkf.org.my)
  • Many times the disease can lead to kidney damage and even kidney failure. (nkf.org.my)
  • The Division provides consultative and follow-up care for patients with all types of kidney and liver disease. (utsouthwestern.edu)
  • Pancreas after kidney (PAK) transplant: Patients with diabetes who have had a prior kidney transplant performed for end-stage renal disease may be a suitable candidate to receive a pancreas transplant at a later date. (uhhospitals.org)
  • Facing end-stage kidney disease (ESKD) requires coordinated efforts across multiple sectors, from boosting prevention strategies, to ensuring access to renal replacement therapy, including by strengthening transplantation programs. (who.int)
  • Allogeneic Hematopoietic Stem Cell Transplantation Can Improve Prognosis of Extramedullary Infiltration Pos. (annalsoftransplantation.com)
  • It is almost always done when someone with type 1 diabetes also needs a kidney transplant. (medlineplus.gov)
  • When your child needs a kidney transplant, your entire family will benefit from our compassionate team of experts. (uwhealth.org)
  • More than 95% of people survive at least 1 year after transplantation. (msdmanuals.com)
  • We've been serving pediatric kidney transplant patients and their families for more than 55 years. (uwhealth.org)
  • Our pediatric kidney transplant wait times are shorter than regional and national averages, and our living donation program is one of the largest in the nation. (uwhealth.org)
  • US examination showing marked hydronephrosis (yellow arrows) in a kidney transplant recipient with hematuria. (mhmedical.com)
  • Hyponatremia: A possible immuno-neuroendocrine interface with COVID-19 in a kidney transplant recipient. (doximity.com)
  • Neuropathy improves after both kidney and pancreas transplantation, suggesting that renal failure and diabetes contribute to the sensory neuropathy commonly observed at the time of transplantation. (medscape.com)
  • With a new kidney, you will no longer experience renal failure, and your new pancreas will maintain your blood sugars at a normal level. (emoryhealthcare.org)
  • Simultaneous pancreas and kidney (SPK) transplant: This combined transplant treats both diabetes and renal failure in one operation. (uhhospitals.org)
  • Also, some PRO measures may lack sensitivity to detect actual changes, as they exclude issues and domains of life likely to be important for QoL post-transplantation and when patients may no longer perceive themselves to have diabetes. (ncl.ac.uk)
  • Deonna Moore, NP, presented "Living Kidney Donor Evaluation and Factors Leading to Non-Donation" at the UNOS Tranplant Management Forum in Orlando, Florida, and at the American Transplant Congress. (vumc.org)
  • Is It Time to Utilize Genetic Testing for Living Kidney Donor Evaluation? (doximity.com)
  • A pancreas transplant can cure diabetes and eliminate the need for insulin shots. (medlineplus.gov)
  • Experiments in pancreas transplantation began long before the discovery of insulin. (medscape.com)
  • The pancreas makes a substance called insulin. (medlineplus.gov)
  • In people with type 1 diabetes , the pancreas has lost the ability to make insulin. (medlineplus.gov)
  • The standard treatment for diabetes is to take insulin to replace what the pancreas isn't producing. (ucsfhealth.org)
  • Insulin is a hormone produced by the pancreas. (nkf.org.my)
  • Occurs mainly in young people below 30 years and is caused by an inability of the pancreas to produce enough insulin. (nkf.org.my)
  • In type 1 diabetes, your body's immune system attacks the insulin-producing cells of the pancreas. (emoryhealthcare.org)
  • As a result, your pancreas makes little or no insulin, causing the level of your blood sugar to rise. (emoryhealthcare.org)
  • In type 2, although the pancreas still makes insulin, the body resists the action of that insulin. (emoryhealthcare.org)
  • More than 80% of people who have diabetes and who receive a pancreas transplant have normal blood sugar levels afterward and no longer need insulin , but they trade this benefit for the need to take immunosuppressants, with the risk of infections and other side effects. (msdmanuals.com)
  • Because injectable insulin is a safe and reasonably effective treatment for diabetes, freedom from insulin is not considered a sufficient reason for pancreas transplantation. (msdmanuals.com)
  • Diabetes results from loss or dysfunction of insulin producing beta cells in the pancreas. (lu.se)
  • Dr. Sung Ho Hyon is Director of the Kidney and Pancreas Transplantation Program at Hospital Italiano de Buenos Aires, the largest multi-organ transplant center in Argentina. (diabetesvoice.org)
  • Over time, the kidneys of patients with diabetes may be damaged by the body's inability to maintain the proper balance of glucose. (emoryhealthcare.org)
  • Pancreas transplant alone (PTA): Patients with type I diabetes who have good kidney function but have severe difficulty controlling blood glucose levels and who experience severe hypoglycemic episodes are eligible for this type of transplant. (uhhospitals.org)
  • As one of the largest liver transplantation centers in the nation, Mount Sinai's surgeons treat adult and pediatric liver patients with innovative treatments and procedures. (mountsinai.org)