Tumors or cancers of the KIDNEY.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Pathological processes of the KIDNEY or its component tissues.
The transference of a kidney from one human or animal to another.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Neoplasms containing cyst-like formations or producing mucin or serum.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)
A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)
The systematic study of the complete DNA sequences (GENOME) of organisms.
Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Acquiring information from a patient on past medical conditions and treatments.
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
The biologic treatment of mental disorders (e.g., ELECTROCONVULSIVE THERAPY), in contrast with psychotherapy. (Stone, American Psychiatric Glossary, 1988, p159)
Systematic and thorough inspection of the patient for physical signs of disease or abnormality.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)
The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.
The sebaceous glands situated on the inner surface of the eyelids between the tarsal plates and CONJUNCTIVA.
Review of claims by insurance companies to determine liability and amount of payment for various services. The review may also include determination of eligibility of the claimant or beneficiary or of the provider of the benefit; determination that the benefit is covered or not payable under another policy; or determination that the service was necessary and of reasonable cost and quality.
The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.
An order of rod-shaped, gram-negative fruiting gliding bacteria found in SOIL; WATER; and HUMUS.
Hydrazine substituted by one methyl group.
A condition of metabolic imbalance that is caused by complications of initially feeding a severely malnourished patient too aggressively. Usually occurring within the first 5 days of refeeding, this syndrome is characterized by WATER-ELECTROLYTE IMBALANCE; GLUCOSE INTOLERANCE; CARDIAC ARRHYTHMIAS; and DIARRHEA.
The state of having multiple leiomyomas throughout the body. (Stedman, 25th ed)

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. (1/5944)

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.  (+info)

Surgery-related factors and local recurrence of Wilms tumor in National Wilms Tumor Study 4. (2/5944)

OBJECTIVE: To assess the prognostic factors for local recurrence in Wilms tumor. SUMMARY BACKGROUND DATA: Current therapy for Wilms tumor has evolved through four studies of the National Wilms Tumor Study Group. As adverse prognostic factors were identified, treatment of children with Wilms tumor has been tailored based on these factors. Two-year relapse-free survival of children in the fourth study (NWTS-4) exceeded 91%. Factors once of prognostic import for local recurrence may lose their significance as more effective therapeutic regimens are devised. METHODS: Children evaluated were drawn from the records of NWTS-4. A total of 2482 randomized or followed patients were identified. Local recurrence, defined as recurrence in the original tumor bed, retroperitoneum, or within the abdominal cavity or pelvis, occurred in 100 children. Using a nested case-control study design, 182 matched controls were selected. Factors were analyzed for their association with local failure. Relative risks and 95% confidence intervals were calculated, taking into account the matching. RESULTS: The largest relative risks for local recurrence were observed in patients with stage III disease, those with unfavorable histology (especially diffuse anaplasia), and those reported to have tumor spillage during surgery. Multiple regression analysis adjusting for the combined effects of histology, lymph node involvement, and age revealed that tumor spillage remained significant. The relative risk of local recurrence from spill was largest in children with stage II disease. The absence of lymph node biopsy was also associated with an increased relative risk of recurrence, which was largest in children with stage I disease. The survival of children after local recurrence is poor, with an average survival rate at 2 years after relapse of 43%. Survival was dependent on initial stage: those who received more therapy before relapse had a worse prognosis. CONCLUSIONS: This study has demonstrated that surgical rupture of the tumor must be prevented by the surgeon, because spills produce an increased risk of local relapse. Both local and diffuse spills produce this risk. Stage II children with local spill appear to require more aggressive therapy than that used in NWTS-4. The continued critical importance of lymph node sampling in conjunction with nephrectomy for Wilms tumor is also established. Absence of lymph node biopsy may result in understaging and inadequate treatment of the child and may produce an increased risk of local recurrence.  (+info)

Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients. (3/5944)

Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5FU), thereby limiting the efficacy of the therapy. To identify patients suffering from a complete or partial DPD deficiency, the activity of DPD is usually determined in peripheral blood mononuclear cells (PBM cells). In this study, we demonstrated that the highest activity of DPD was found in monocytes followed by that of lymphocytes, granulocytes and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in PBM cells proved to be intermediate compared with the DPD activity observed in monocytes and lymphocytes. The mean percentage of monocytes in the PBM cells obtained from cancer patients proved to be significantly higher than that observed in PBM cells obtained from healthy volunteers. Moreover, a profound positive correlation was observed between the DPD activity of PBM cells and the percentage of monocytes, thus introducing a large inter- and intrapatient variability in the activity of DPD and hindering the detection of patients with a partial DPD deficiency.  (+info)

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. (4/5944)

Tissue inhibitor of metalloproteinase-3 (TIMP-3) antagonizes matrix metalloproteinase activity and can suppress tumor growth, angiogenesis, invasion, and metastasis. Loss of TIMP-3 has been related to the acquisition of tumorigenesis. Herein, we show that TIMP-3 is silenced in association with aberrant promoter-region methylation in cell lines derived from human cancers. TIMP-3 expression was restored after 5-aza-2'deoxycytidine-mediated demethylation of the TIMP-3 proximal promoter region. Genomic bisulfite sequencing revealed that TIMP-3 silencing was related to the overall density of methylation and that discrete regions within the TIMP-3 CpG island may be important for the silencing of this gene. Aberrant methylation of TIMP-3 occurred in primary cancers of the kidney, brain, colon, breast, and lung, but not in any of 41 normal tissue samples. The most frequent TIMP-3 methylation was found in renal cancers, which originate in the tissue that normally expresses the highest TIMP-3 levels. This methylation correlated with a lack of detectable TIMP-3 protein in these tumors. Together, these data show that methylation-associated inactivation of TIMP-3 is frequent in many human tumors.  (+info)

Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. (5/5944)

In the Eker rat, a germ-line mutation in the homologue of the human tuberous sclerosis gene (Tsc2) causes renal cell carcinomas (RCs) with a complete penetrance in all heterozygotes. Tsc2 mutations have also been found in a subset of chemically induced non-Eker rat RCs. Because tuberous sclerosis patients with alteration of either of the two predisposing genes (TSC1 and TSC2) show identical symptoms, the products of these two genes are thought to be involved in a common biological pathway. In this study, to analyze the possible overlap between the functions of Tsc2 and Tscl gene products, we isolated and characterized a rat homologue of the TSC1 gene (Tsc1). The rat Tsc1 gene, which has an identical exon-intron structure to that of human TSC1 and is localized on rat chromosome 3, has been shown to encode a protein (hamartin) that is highly homologous to the human counterpart with an approximately 86% amino acid sequence identity. Using PCR-single-strand conformational polymorphism analysis, we identified two splicing donor site mutations in one chemically induced rat RC (1 of 15). This suggests that alterations of the Tsc1 gene may be involved in the development of a subset of rat RCs.  (+info)

Presentation of renal tumor antigens by human dendritic cells activates tumor-infiltrating lymphocytes against autologous tumor: implications for live kidney cancer vaccines. (6/5944)

The clinical impact of dendritic cells (DCs) in the treatment of human cancer depends on their unique role as the most potent antigen-presenting cells that are capable of priming an antitumor T-cell response. Here, we demonstrate that functional DCs can be generated from peripheral blood of patients with metastatic renal cell carcinoma (RCC) by culture of monocytes/macrophages (CD14+) in autologous serum containing medium (RPMI) in the presence of granulocyte macrophage colony-stimulating factor and interleukin (IL) 4. For testing the capability of RCC-antigen uptake and processing, we loaded these DCs with autologous tumor lysate (TuLy) using liposomes, after which cytometric analysis of the DCs revealed a markedly increased expression of HLA class I antigen and a persistent high expression of class II. The immunogenicity of DC-TuLy was further tested in cultures of renal tumor infiltrating lymphocytes (TILs) cultured in low-dose IL-2 (20 Biologic Response Modifier Program units/ml). A synergistic effect of DC-TuLy and IL-2 in stimulating a T cell-dependent immune response was demonstrated by: (a) the increase of growth expansion of TILs (9.4-14.3-fold; day 21); (b) the up-regulation of the CD3+ CD56- TcR+ (both CD4+ and CD8+) cell population; (c) the augmentation of T cell-restricted autologous tumor lysis; and (d) the enhancement of IFN-gamma, tumor necrosis factor-alpha, granulocyte macrophage colony-stimulating factor, and IL-6 mRNA expression by TILs. Taken together, these data implicate that DC-TuLy can activate immunosuppressed TIL via an induction of enhanced antitumor CTL responses associated with production of Thl cells. This indicates a potential role of DC-TuLy vaccines for induction of active immunity in patients with advanced RCC.  (+info)

A possible contributory role of BK virus infection in neuroblastoma development. (7/5944)

The tumor suppressor protein p53 is aberrantly localized to the cytoplasm of neuroblastoma cells, compromising the suppressor function of this protein. Such tumors are experimentally induced in transgenic mice expressing the large tumor (T) antigen of polyomaviruses. The oncogenic mechanisms of T antigen include complex formation with, and inactivation of, the tumor suppressor protein p53. Samples from 18 human neuroblastomas and five normal human adrenal glands were examined. BK virus DNA was detected in all neuroblastomas and none of five normal adrenal glands by PCR. Using DNA in situ hybridization, polyomaviral DNA was found in the tumor cells of 17 of 18 neuroblastomas, but in none of five adrenal medullas. Expression of the large T antigen was detected in the tumor cells of 16 of 18 neuroblastomas, but in none of the five adrenal medullas. By double immunostaining BK virus T antigen and p53 was colocalized to the cytoplasm of the tumor cells. Immunoprecipitation revealed binding between the two proteins. The presence and expression of BK virus in neuroblastomas, but not in normal adrenal medulla, and colocalization and binding to p53, suggest that this virus may play a contributory role in the development of this neoplasm.  (+info)

Immunohistochemical detection of JC virus in nontumorous renal tissue of a patient with renal cancer but without progressive multifocal leukoencephalopathy. (8/5944)

We performed immunohistochemical staining on the nontumorous renal tissue of 45 patients with renal cancer but without progressive multifocal encephalopathy using JCV-specific antibody. For one patient we found positive staining of the nuclei of the renal collecting ducts. Immunoelectron microscopic examination of the positive cell nuclei revealed electron-dense polyomavirus-like particles.  (+info)

Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known function. Lack of VHL expression has been shown previously to sensitize renal cells to apoptosis caused by certain cellular stresses. In this report, the role of HIF-α in apoptosis was investigated using two parent VHL-null renal carcinoma cell lines. 786-O and RCC10 renal carcinoma cell lines with manipulated levels of VHL, HIF-1α, or HIF-2α were subjected to cellular stresses and analyzed by western blotting for the abundance of apoptotic markers. Cell lines expressing mutant VHL proteins that were unable to regulate HIF-α had increased levels of apoptosis when irradiated with ultraviolet (UV) light. The influences of the two major isoforms of HIF-α, HIF-1α and HIF-2α, on apoptosis, were
Small Renal tumors: Are patients being properly counseled? With your host, Dr. Gary Kohn, is Robert Houston Thompson, Urologic Oncology Fellow, at Memorial Sloan Kettering Cancer Center in New York. Join the discussion as Dr. Thompson covers the management of small renal tumors, highlighting survival rates of patients treated with partial vs. radical nephrectomies.
TY - JOUR. T1 - Radiofrequency ablation of small renal cortical tumours in healthy adults. T2 - Renal function preservation and intermediate oncological outcome. AU - Stern, Joshua M.. AU - Gupta, Amit. AU - Raman, Jay D.. AU - Cost, Nicholas. AU - Lucas, Steven. AU - Lotan, Yair. AU - Raj, Ganesh. AU - Cadeddu, Jeffrey A. PY - 2009/9/1. Y1 - 2009/9/1. N2 - OBJECTIVES To present the glomerular filtration rate (GFR) and oncological outcomes in a series of patients with cT1a renal cortical tumours treated with radiofrequency ablation (RFA), a non-ischaemic minimally invasive ablative method, as nephron-sparing surgery gives excellent oncological outcomes and preserves renal function. PATIENTS AND METHODS Healthy (American Society of Anesthesiologists, ASA, I and II) patients with cT1a renal masses were identified, and clinical and radiographic data were reviewed to assess indications, complications, radiological evidence of disease recurrence, and renal function. Changes in GFR were calculated. ...
Cases reported • Kidney Neoplasms; Cancer of Kidney; Kidney Cancer; Renal Cancer. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
TY - JOUR. T1 - In-phase signal intensity loss in solid renal masses on dual-echo gradient-echo MRI. T2 - Association with malignancy and pathologic classification. AU - Childs, David D.. AU - Clingan, M. Jennings. AU - Zagoria, Ronald J.. AU - Sirintrapun, Joseph. AU - Tangtiang, Kaan. AU - Anderson, Andrea. AU - Leyendecker, John R.. PY - 2014/10/1. Y1 - 2014/10/1. N2 - OBJECTIVE. The purposes of this study were to determine the prevalence of in-phase signal intensity loss on dual-echo gradient-echo MRI in solid renal masses using visual and quantitative techniques and to test for any association between in-phase signal intensity loss and pathologic classification. MATERIALS AND METHODS. The renal MRI studies of 177 patients (192 solid masses consisting of 166 renal cell carcinomas [RCCs], four malignant non-RCCs, and 22 benign tumors) were qualitatively reviewed by two blinded readers for visual evidence of relative in-phase signal intensity loss. For lesions without visual evidence, ...
Malignant Kidney Neoplasm except Renal Pelvis (Malignant Neoplasm of Kidney except Renal Pelvis): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Metastasis-associated protein 2 (MTA2) was previously known as a requirement to maintain malignant potentials in several human cancers. However, the role of MTA2 in the progression of renal cell carcinoma (RCC) has not yet been delineated. In this study, MTA2 expression was significantly increased in RCC tissues and cell lines. Increased MTA2 expression was significantly associated with tumour grade (p = 0.002) and was an independent prognostic factor for overall survival with a high RCC tumour grade. MTA2 knockdown inhibited the migration, invasion, and in vivo metastasis of RCC cells without effects on cell proliferation. Regarding molecular mechanisms, MTA2 knockdown reduced the activity, protein level, and mRNA expression of matrix metalloproteinase-9 (MMP-9) in RCC cells. Further analyses demonstrated that patients with lower miR-133b expression had poorer survival rates than those with higher expression from The Cancer Genome Atlas database. Moreover, miR-133b modulated the 3′untranslated
Activation of the proto-oncogene ras may play a critical role in the development and rapid progression of different types of human cancers, including renal cancer. It has been shown that the Ras pathway can mediate pro-survival signals in cancer cells by inhibiting cellular apoptosis. It is established that the cytoprotective enzyme heme oxygenase-1 (HO-1) is over-expressed in several cancers, and may play a significant role in the growth and metastasis of tumors by inducing cell survival pathways. However, it is not known if there is an association between Ras activation and HO-1 over-expression in cancer. We have recently demonstrated that the treatment of human renal cancer cells with the immunosuppressive agent cyclosporine may activate the H-Ras pathway, and promote a rapid progression of the disease. We have also shown that HO-1 is over-expressed in human renal cancer, and plays a key role in the survival of renal cancer cells by inhibiting cellular apoptosis. Here, we wished to analyze if ...
Background 209 000 new cases of renal carcinoma are diagnosed each full year worldwide and new therapeutic focuses on are urgently needed. service and improved NMU appearance. On the other hand, reductions of HIF in VHL faulty RCC cells via siRNA of HIF- subunits or appearance of Type 2C mutant VHLh decreased NMU appearance amounts. We also display that renal tumor cells specific a practical NMU receptor (NMUR1), and that NMU stimulates migration of renal tumor cells. Results These results recommend that NMU may work in an autocrine style, advertising development of kidney tumor. Hypoxia and HIF appearance are regularly noticed in many non-renal malignancies and are connected with a poor diagnosis. Our research increases the probability that HIF might drive NMU phrase in non-renal tumours also. Results Kidney tumor is responsible for 102 000 fatalities per yr diagnosis and worldwide is generally poor [1]. Crystal clear cell renal cell carcinoma (CCRCC) can be the commonest type of kidney tumor ...
Everolimus (RAD001, Afinitor) is an mTOR inhibitor FDA-approved for the treatment of patients with advanced clear cell renal cancer (RCC) after failure of treatment with sunitinib or sorafenib, or both drugs. It targets the mammalian target of rapamycin (mTOR) complex inhibiting a serine/threonine kinase regulating PI3K/AKT signaling pathway. Previous evidences demonstrated that the activation of the chemokine receptor CXCR4 involved the mTOR pathway and that CXCR4 was overexpressed in RCC. Recently, also the deorphanized chemokine receptor CXCR7 was described in RCC and defined as an independent prognostic factor. Nevertheless, little is known about the CXCR4-CXCL12-CXCR7-induced signalling. Aim of the study was to investigate if the CXCL12/CXCR4/CXCR7 complex could transduce the signal through mTOR identifying new therapeutic targets. In human renal cancer cells (RXF393, A498) treatment with CXCL12, the CXCR4 and CXCR7 ligand, induced mTOR pathway, as demonstrated through p70S6K and eukaryotic ...
Sunitinib plays an important role in managing the metastatic renal cell cancer (mRCC). Sunitinib-induced hypothyroidism is a common side-effect of the drug.
We found that knocking down these transcripts in vitro with antisense oligonucleotide (ASO) induces selective death of several human and murine tumor cell lines without affecting viability of normal cells. The aim of this study was to evaluate in vitro and in vivo, the therapeutic value of silencing the ASncmtRNA with ASO in human cell lines/primary cultures and in A498 xenograft and Patient derived xenograft (PDX) RCC model.. Methods: For the in vitro studies we used different human renal carcinoma cell lines (786-O, Caki-1, A498) and 6 primary cultures derived from RCC patients. Knock down of the ASncmtRNA was achieved by transfection of ASO targeted to the loop region of these transcripts (Andes-1537). As control, we used ASO with unrelated sequence (NR-ASO). Cell death was evaluated with FACS by PI and tripan exclusion assay and the decrease in tumorigenicity was determined by sphere assay. The apoptosis hallmarks evaluated were Caspase activation, DNA fragmentation and phosphatidylserine ...
Histologically documented metastatic renal cell cancer with a component of clear cell histology.. - Evidence of measurable disease.. - Patients with mRCC must have received no prior systemic first-line therapy or must have progressive disease per RECIST (version 1.0) after one prior systemic first line regimen for metastatic disease containing sunitinib, cytokine(s), or both.. ...
The International Consortium for the Investigation of Renal Malignancies (I-ConFIRM) was formed to promote international, multidisciplinary collaborations to advance our understanding of the etiology and outcomes of kidney cancer.
Kidney Cancer, also known as renal cancer is a type of cancer which forms tumours in different parts of Kidneys.. Almost all kidney cancers initially appear in the lining of tiny tubes of the Kidney and such kidney cancer is called renal cell carcinoma. The good thing about this cancer is that it can be detected earlier than any other type of cancer, and hence its spreading can be stopped. But even in the case of kidney cancer, tumours may grow large before it is detected.. The main job of Kidneys is to purify the blood by filtering harmful substances and to make urine. Thus any urine related problem can be early signs of kidney cancer. Just like any other form of cancer, even kidney cancers have some stages.. Stages of Kidney Cancer. There are various stages of Kidney Cancer. As the steps grow, Kidney Cancer becomes more dangerous. The stages are -. Stage I. A tumour is smaller than 7, which are only in the Kidney.. Stage II. A tumour is equal to or larger than 7, which are only in the ...
New life-saving treatments for Colorectal cancer in clinical trial on A Phase IIb, Nonrandomized, Open-Label Trial with Mouse Renal Adenocarcinoma (RENCA) Cell Containing Agarose-Agarose Macrobeads Compared with Best Supportive Care in Patients with Treatment-Resistant, Metastatic Colorectal Carcinoma
Learn how Avastin® (bevacizumab) is designed to work for the treatment of metastatic kidney cancer (mRCC) Metastatic Colorectal Cancer (mCRC) Avastin is approved to treat metastatic colorectal cancer (mCRC) for: First- or second-line treatment in combination with intravenous 5-fluorouracil-based chemotherapy Second-line treatment when used with fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy after cancer progresses following a first-line treatment that includes Avastin. Avastin is not approved for use after the primary treatment of colon cancer that has not spread to other parts of the body. Glioblastoma (GBM) Avastin is approved to treat glioblastoma (GBM) when taken alone in adult patients whose cancer has progressed after prior treatment (recurrent or rGBM). The effectiveness of Avastin in rGBM is based on tumor response. Currently, no data have shown whether or not Avastin improves disease-related symptoms or survival in people with rGBM. Non-Small Cell Lung Cancer
Kidney Cancer Canada provides the latest Kidney cancer information and kidney cancer facts about kidney cancer therapy and kidney cancer support.
WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- An experimental drug may show promise in treating kidney cancer, researchers say.. The drug CB-839 is the first to target an enzyme that cancer cells require to stay alive, researchers said. This stage 1 clinical trial found that the drug was effective in most patients with advanced kidney cancer when used in combination with another cancer drug called everolimus (Afinitor, Zortress).. In the 15 patients in the study, the dual treatment controlled tumors in 93 percent of the patients, who had either clear cell or papillary renal cell cancer. Tumors shrank by more than 30 percent in one patient, were stable in 13 patients, and grew by more than 20 percent in one patient.. Clear cell is the most common form of kidney cancer, accounting for 75 percent of cases, the researchers said. All 12 patients with this type of kidney cancer had their disease controlled. Papillary renal cell cancer is the next most common form of kidney cancer and accounts for 10 ...
Metastatic renal cell carcinoma is one of the most treatment-resistant malignancies and patients have dismal prognosis, said Dr. George M. Yousef, a laboratory pathologist. Identification of markers that can predict the potential of metastases will have a great impact on improvement patient outcomes.. Dr. Yousefs research appears online in the journal Molecular & Cellular Proteomics.. Kidney cancer in general is very aggressive and has a high chance of metastasis, or spreading to other organs. The five-year survival rate for metastasized kidney cancer is less than 10 per cent. Although imaging technology has led to increased detection of kidney tumours, 25 to 30 per cent have already spread by the time they are found.. Using a mass spectrometer, Dr. Yousef identified 29 proteins that change when cancer cells spread from the original site of the kidney tumour. All 29 proteins have been previously been linked to other malignancies.. Dr. Yousef said if physicians can determine which kidney ...
Mucinous tubular and spindle cell carcinoma (MTSCC) is rare in renal cell carcinoma (RCC) and usually demonstrates a low nuclear grade and a better prognosis compared with other RCCs. The authors present a case report of MTSCC containing an area of Fuhrman nuclear grade 3, in addition to an area with a micropapillary pattern. An 82-year-old man consulted a hospital due to macrohematuria, and a tumor in the right kidney was detected. The tumor was resected and histologically examined. The tumor consisted of various growth patterns: Elongated tubular structure, a papillary structure containing a micropapillary pattern and solid pattern with spindle cells ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
RCC has a unique biological profile, with a long dormancy of metastasis (3) . Some patients with RCCs believed to be curable with radical nephrectomy develop distant metastasis 5-10 years after surgery. RCC probably spreads mainly by a hematogenous mechanism. It was reported that serum microsatellite alterations were found in more than 50% of patients with RCC (16 , 17) ; this probably reflects the hematogenous mechanism by which renal tumors spread. Thus, it would be very useful to identify a tumor marker for RCC for monitoring patients after surgery and determining postoperative adjuvant chemotherapy.. It was recently reported that MN/CA9 might be useful as a diagnostic marker for RCCs (18 , 19) . The VHL tumor suppressor gene was isolated in 1993 (20) . Somatic mutations of the VHL gene have been detected in up to 60% of sporadic clear cell RCCs, the predominant form of kidney cancer (11, 12, 13) . In this study, we demonstrated that nested RT-PCR using VHL gene mutation can detect the ...
Kidneys are not exempted from having cancer. Today, a lot of people suffer from kidney Cancer and are taking various medications as treatment. Kidney tumor is a rare form of Cancer and the cure of Kidney Cancer depends on the stage at which the kidney Cancer was detected in a patient. Being knowledgeable of this disease helps you prepare your body for the treatment, and in some cases, avoid having this problem in the long run.. Several vital information you must learn about kidney cancer includes the following:. Kidney Cancer Statistics. Understanding kidney cancer, also known as renal cancer, through numbers is important for people today. According to American Cancer Societys 2013 forecast, approximately 65,000 new cases of cancer will be listed this year, with two-thirds of them being male patients. Estimated death statistics due to this problem is around 13,500 cases.. Patients who have been diagnosed with renal cancer are concerned about the 5-year survival rates noted down on this disease. ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Image-guided ablation of primary renal cancers may be performed with minimal morbidity and produce excellent results in terms of long-term survival.
Kidney Cancer: What is Kidney Cancer?, Kidney Cancer occurs when healthy cells in one or both kidneys grow out of control and form a lump (called a tumor). Renal cell carcinoma is the most common type of kidney cancer in adults.
Congress : ESMO. Authors : S Negrier, N Rioux-Leclercq, A Ravaud, G Gravis, L Geoffrois, C M Chevreau, F Rolland, E Blanc, C Segura-Ferlay, D Perol, M Gross Goupil, S Dermeche, A Flechon, L Albiges, B Escudier.. Experts group or program : Groupe détude des tumeurs urogénitales (GETUG). PRC represents 10-15% of renal carcinomas; there is no standard treatment at the metastatic stage. Few trials were conducted with sunitinib, everolimus and more recently savolitinib, with disappointing response rates. Axitinib, an inhibitor of VEGF receptors, indicated as 2d line treatment in advanced renal cell carcinoma was investigated.. En savoir plus. ...
ASCO GU 2020, combination immunotherapy and immunotherapy/anti-angiogenic therapy combinations, phase I-II study of sitravatinib combined with nivolumab in patients who have previously progressed on TKI therapy for accRCC
Title:Current Management of Fetal and Neonatal Renal Tumors. VOLUME: 11 ISSUE: 3. Author(s):Michael Berger and Dietrich von Schweinitz. Affiliation:Department of Pediatric Surgery, Dr. von Hauner Childrens Hospital, Ludwig Maximilians University Munich, Lindwurmstrasse 4, 80337 Munich, Germany.. Keywords:Fetal renal tumors, fetal tumors, neonatal tumors.. Abstract:Fetal and neonatal renal tumors are rare. Nevertheless, in-depth understanding of their features can lead to early recognition and appropriate treatment, ultimately benefiting outcome. Despite the many obvious similarities, important distinctions exist between these tumors and their counterparts in older children. Likewise, some important distinctions exist between fetal tumors on the one hand and neonatal tumors on the other. In this article, we review the pertinent features of fetal and neonatal renal tumors and specifically point out the important individualities in their clinical management.. ...
About 6% to 7% of kidney cancers begin not in the kidney itself, but in the renal pelvis, the point where the kidney joins the ureter (the tube running from the kidney to the bladder). These tumors are called transitional cell carcinomas, and are made up of cancer cells different from those that characterize RCC. Research indicates these tumors are caused by cigarette smoking. A relatively rare form of kidney cancer, Wilms tumor (also known as nephroblastoma) accounts for about 5% to 8% of kidney tumors in children. Renal sarcoma is a rare disease of the kidneys connective tissues that accounts for less than 1% of all kidney tumors.
What is kidney cancer? Kidney Cancer Canada provides kidney cancer facts and kidney cancer information about kidney cancer through kidney cancer support group.
Renal Metastasis of Esophageal Squamous Cell Carcinoma- A Case Report and Literature Review. PubMed, SCI, Scopus, ESCI, PMC indexed
Gyula Kovacs, Mohammed Akhtar, Bruce J. Beckwith, Peter Bugert, Colin S. Cooper, Brett Delahunt, John N. Eble, Stewart Fleming, Börje Ljungberg, L. Jeffrey Medeiros, Holger Moch, Victor E. Reuter, Eberhard Ritz, Goran Roos, Dietmar Schmidt, John R. Srigley, Stephan Störkel, Eva van den Berg, Bert Zbar ...
I need all my fans to pray for me. Doctor just told me I have cancer on my kidneys. Prayer is power, thats why Im letting the world know prayfaboosie.. Kidney cancer is rare. Only 65,000 cases of kidney cancer are reported annually in the United States. Compare that with 1.8 million lung cancer diagnoses reported in 2012. Kidney cancer accounts for only 2% of all cancer cases reported in the U.S.. CAUSES. The factors that are at high risk for kidney cancer include family history of kidney cancer, smoking, taking over the counter NSAIDs pain medicine (Aspirin, Motrin, Aleve, Naprosyn); hepatitis C, and dialysis.. SIGNS and SYMPTOMS. Signs and symptoms include abdominal distention, abdominal mass (hard or soft), abdominal pain, blood in urine.. TREATMENT Treatment for kidney cancer depends on the stage of cancer (1-4). Treatment includes chemotherapy and radiation, cancer drugs and immunotherapy, partial or total nephrectomy (removal of affected kidney).. 5-year survival rate is 73% in the ...
I am new to this forum. I have been reading quite a number of discussions on this forum and found them very informative and helpful. I am a not so old guy (61 years old) with pretty good health generally. However, last Dec, I was found to have a small renal tumor in my left kidney (about 1.6 cm) which was highly likely to be RCC. After some further imaging, I went through an open partial nephrectomy at end Jan this year. The surgery was successful. The path report shows that the tumor was stage T1a RCC clear cell grade 3. No spread. All negative margins. What I am concerned is about the grade 3. I wonder why such a small tumor could be grade 3. I will have a post-op follow-up visit with the urological surgeon and wonder what I need to discuss with him. Also I will be travelling by air back to my southeast hometown from NYC (about 2-hr flight) in a week (about 3.5 weeks after the surgery), I wonder if that should be OK. My incision looks healed, but there is still some pain inside. Thanks for ...
This was a non-interventional, multicenter study to evaluate efficacy and safety of intravenous Avastin in combination with interferon alpha-2a for first-line
Renal Cell Cancer or Hypernephroma is a serious pathological condition of the kidney. Read the Causes, Symptoms, Treatment, Diagnosis, Prognosis, Complications.
The kidneys are paired bean-like organs located in the back of the abdominal cavity in the retroperitoneum. The kidneys play a large role in the regulation of wastes, electrolytes, water, blood pressure and acid-base balance throughout the body. Although it is normal to have two kidneys, it is quite possible to live with just one.. The most common type of kidney cancer is called renal cell carcinoma (RCC). Risk factors include smoking, regular use of non-steroidal anti-inflammatories such as ibuprofen and naproxen, a family history of kidney cancer, and renal disease requiring dialysis. Most commonly, kidney cancer is detected incidentally on imaging for some other purpose and has no signs or symptoms. In cases where the cancer has formed a larger tumor, a patient may experience flank pain, a mass in the abdomen, or blood in the urine that is either visable or apparent on a dipstick test. Other tests to help stage the extent of kidney cancer may include a CT scan of the abdomen and pelvis to ...
1) After treatment for kidney cancer, routine life-long surveillance is necessary with periodic assessment by a physician, blood tests and X-rays. Unfortunately there are no proven ways to prevent recurrence 2) Patients with only one kidney after removal of the other usually have no adverse effects or handicaps although contact sports and drugs that can damage the kidney should be avoided. 3) There are many factors that affect outcome after treatment for kidney cancer. The two most important prognostic factors are tumor stage and grade. Higher stage and grade implies a lower chance of cure. 4) For kidney tumors, needle biopsy is usually not indicated because more than 90 percent of solid kidney tumors are cancer and biopsies have a significant rate of false-negatives. 5) In patients without lymphadenopathy, lymph node dissection does not improve the survival. In patients with enlarged regional lymph nodes and distant metastasis, recent data suggest that lymph node dissection improves survival. ...
I investigated the influence of the phosphatidylinositol 3-kinase (PI3K)Akt pathway on HSF1 activation status. Despite effecting significant up-regulation of the PI3k/Akt pathway with insulin and insulin-like growth factor-1 (IGF-1), I did not demonstrate any change in the HSF1 trimerisation state, DNA-binding ability or nuclear localisation in renal adenocarcinoma cells (ACHN). Following treatment with insulin, a 5-fold increase in heme oxygenase-1 (HO-1) mRNA and a 4-fold increase in protein expression were observed in ACHN cells; insulin-induced HO-1 expression was also demonstrated in mouse primary tubular epithelial cells. The induction of HO-1 in ACHNs was blocked by actinomycin D and cycloheximide and was abolished by the PI3K inhibitor, LY294002, but not by the inactive analogue, LY303511. Over-expressing a dominant-negative form of Akt abrogated the HO-1 inducing effects of insulin, whereas cells transfected with a constitutively active Akt construct demonstrated an increase in HO-1 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
According to experts, kidney cancer is one of the 10 most common forms of cancer in men and women alike. If you want to know some of the things that you may do to dodge this deadly disease, continue reading. Below we will discuss the risk factors for kidney cancer.. When risk factors are being talked about, things that are known to increase your likelihood of developing certain diseases are the ones involved. So in this case, risk factors for kidney cancer are those that can cause your odds of having cancer of the kidneys to increase.. Some risk factors for kidney cancer are non-preventable, which means that you have no control over them. Examples of these types of risk factors for kidney cancer are:. ...
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
All opinions expressed on the website are those of the respective authors and not of their employer. Information provided here is for medical education only. It is not intended as and does not substitute for medical advice. If you are a patient, please see your doctor for evaluation. The appearance of external hyperlinks to other websites does not constitute endorsement. We do not verify, endorse or take responsibility for the accuracy, currency, completeness or quality of the content contained in these sites. There is no real life patient data on this website. The Renal Fellow Network does not profit from any of the material on this website. No advertisements are accepted. The Renal Fellow Network is not funded by any agency or company. Any information collected by our website, such as email addresses, will never be passed on to any third party, unless required by law. The Renal Fellow Network is moderated occasionally and posteriorly. Moderators are volunteers. Internet users posting comments ...
Hybridization with cDNA arrays was used to obtain expression profiles of 214 protein-tyrosine kinase, protein-tyrosine phosphatase, dual specificity phosphatase, and other genes for kidney carcinomas (KC) and normal kidney tissues of 34 patients and for seven carcinoma cell lines. Computer analysis revealed three clusters of genes coexpressed in KC. The proliferating- cell gene cluster included MET, VIM, MYC, TOM, PCNA. The neoangiogenesis and blood-cell gene cluster included LCK, HCK, FGR, MAIM, CSFR1, VEGF, FLT1, and KDR. The cluster corresponding to normal, differentiated kidney cells included ERBB2 (HER2) for receptor protein-tyrosine kinase, several phosphatase genes (PTPRE, PTPRB, DUSP9), and EGF. The results suggested that MET, DUSP9, PCNA, TOM, and VIM may serve as diagnostic and prognostic markers in KC. Tubulin and topoisomerase II were assumed to be promising targets for cell proliferation inhibitors in KC. ...
Background: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following targeted therapy in mccRCC have not been evaluated. The aim of this study was to determine methylome/genetic ITH and to evaluate specific epigenetic and genetic changes associated with sunitinib therapy. ...
Part of the NBL Cell Line Collection. This cell line is neither produced nor fully characterized by ATCC. We do not guarantee that it will maintain a specific morphology, purity, or any other property upon passage.
Arm I: Patients receive induction therapy comprising interleukin-2 (IL-2) IV continuously over days 1-5, 15-19, 43-47, and 57-61 (weeks 1, 3, 7, and 9) and interferon alfa (IFN-α) subcutaneously (SC) three times weekly in weeks 1-3 and 7-9. Patients then undergo restaging. Patients achieving a complete response (CR), partial response (PR), or stable disease (SD) then receive maintenance therapy comprising IL-2 IV continuously over 5 days and IFN-α SC three times weekly in weeks 1, 5, 9, and 13 ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Metastatic Renal Cell Carcinoma market report covers research informatics related to Metastatic Renal Cell Carcinoma clinical trials, such as a listing of industry and sponsored clinical trials as well as new drug therapies.. Designed to be a resource both for patients interested in participating in Metastatic Renal Cell Carcinoma clinical trials and for research professionals.. The report, Metastatic Renal Cell Carcinoma Global Clinical Trials Review, H2, 2016″ provides an overview of Metastatic Renal Cell Carcinoma clinical trials scenario. This report provides top line data relating to the clinical trials on Metastatic Renal Cell Carcinoma. Report includes an overview of trial numbers and their average enrolment in top countries conducted across the globe. The report also offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type.. Browse ...
PURPOSE: Careful selection is critical to identify those with metastatic renal cell carcinoma who are most likely to benefit from cytoreductive nephrectomy. Surgery in patients who have metastatic renal cell carcinoma with tumor thrombus is complex and may not benefit some patients with poor overall survival. We evaluated whether preoperative variables or risk stratification systems could predict overall survival following cytoreductive nephrectomy.. MATERIALS AND METHODS: Prognostic factors for overall survival after surgery were evaluated in patients who had metastatic renal cell carcinoma with venous tumor thrombus at 5 institutions from 2000 to 2014. Prognostic variables, including metastatic renal cell carcinoma risk models, were evaluated for associations with overall survival. Multivariable analysis was used to determine independent associations of preoperative variables with overall survival.. RESULTS: A total of 427 patients with metastatic renal cell carcinoma were identified with ...
NOTOC__ For patient information click [[{{PAGENAME}} (patient information),here]] {{Renal cell carcinoma}} {{CMG}}; {{AE}} {{YD}}, {{SSK}}, {{SC}} {{SK}} RCC; Renal cell CA; Kidney cancer; Kidney carcinoma; Kidney CA; Grawitz tumor; Hypernephroma ==[[Renal cell carcinoma overview,Overview]]== ==[[Renal cell carcinoma historical perspective,Historical Perspective]]== ==[[Renal cell carcinoma classification,Classification]]== ==[[Renal cell carcinoma pathophysiology,Pathophysiology]]== ==[[Renal cell carcioma causes,Causes]]== ==[[Renal cell carcinoma differential diagnosis,Differentiating Renal cell carcinoma from other Diseases]]== ==[[Renal cell carcinoma epidemiology and demographics,Epidemiology and Demographics]]== ==[[Renal cell carcinoma risk factors,Risk Factors]]== ==[[Renal cell carcinoma screening,Screening]]== ==[[Renal cell carcinoma natural history, complications, and prognosis,Natural History, Complications and Prognosis]]== ==Diagnosis== [[Renal cell carcinoma ...
This paper presents the conclusions of a workshop entitled Impact of Molecular Genetics on the Classification of Renal Cell Tumours, which was held in Heidelberg in October 1996. The focus on renal cell tumours excludes any discussion of Wilms tumour and its variants, or of tumours metastatic to the kidneys. The proposed classification subdivides renal cell tumours into benign and malignant parenchymal neoplasms and, where possible, limits each subcategory to the most commonly documented genetic abnormalities. Benign tumours are subclassified into metanephric adenoma and adenofibroma, papillary renal cell adenoma, and renal oncocytoma. Malignant tumours are subclassified into common or conventional renal cell carcinoma; papillary renal cell carcinoma; chromophobe renal cell carcinoma; collecting duct carcinoma, with medullary carcinoma of the kidney; and renal cell carcinoma, unclassified. This classification is based on current genetic knowledge, correlates with recognizable histological ...
TY - JOUR. T1 - Vagina as a rare location of renal cell carcinoma metastasis. AU - Ladjevic, I. L.. AU - Stefanovic, A.. AU - Kadija, S.. AU - Terzic, M.. AU - Jeremic, K.. AU - Janjic, T.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Introduction: Metastatic renal cell carcinoma is often found in distant organs, including lung, bone, brain,and liver. Metastases to the vagina are extremely rare. Case Report: The authors present a case of renal cell carcinoma metastasis to the anterior vaginal wall four months after nephrectomy in a 56-year-old patient. The vaginal lesions were excised. After two years the patient had no signs of recurrence or the disease progression. Conclusion: Vaginal metastases should be considered in differential diagnosis of female renal cell carcinoma patients presenting with vaginal bleeding of mass.. AB - Introduction: Metastatic renal cell carcinoma is often found in distant organs, including lung, bone, brain,and liver. Metastases to the vagina are extremely rare. Case Report: ...
Title:Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC). VOLUME: 8 ISSUE: 3. Author(s):Zofia F. Bielecka, Anna M. Czarnecka, Wojciech Solarek, Anna Kornakiewicz and Cezary Szczylik. Affiliation:Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine in Warsaw, Szaserów 128, 04-141 Warsaw, Poland.. Keywords:Acquired drug resistance, tyrosine kinase inhibitors, sunitinib, sorafenib, pazopanib, axitinib, tivozanib, epithelialmesenchymal transition, angiogenic switch, anti-angiogenic therapy, clear-cell renal cell carcinoma, non-genetic resistance mechanisms.. Abstract:Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in offered targeted therapies, ...
Conditional survival of metastatic renal cell carcinoma patients treated with high-dose interleukin-2 David M Gill1†, David D Stenehjem2†, Kinjal Parikh3, Jo
TY - JOUR. T1 - Does timing of cytoreductive nephrectomy impact patient survival with metastatic renal cell carcinoma in the tyrosine kinase inhibitor era? A multi-institutional study. AU - Stroup, Sean P.. AU - Raheem, Omer A.. AU - Palazzi, Kerrin L.. AU - Liss, Michael A.. AU - Mehrazin, Reza. AU - Kopp, Ryan P.. AU - Patel, Nishant. AU - Cohen, Seth A.. AU - Park, Samuel K.. AU - Patterson, Anthony L.. AU - Kane, Christopher J.. AU - Millard, Frederick. AU - Derweesh, Ithaar H.. PY - 2013/4. Y1 - 2013/4. N2 - Objective: To compare outcomes of metastatic renal cell carcinoma (mRCC) patients who underwent primary cytoreductive nephrectomy (CRN), followed by adjuvant sunitinib therapy, vs those who underwent primary sunitinib therapy before planned CRN. Methods: This was a multi-institutional retrospective analysis of 35 mRCC patients from June 2005 to August 2009 (median follow-up, 28.5 months): 17 underwent primary CRN, followed by adjuvant sunitinib (group 1); 18 underwent primary sunitinib ...
TY - JOUR. T1 - Renal oncocytoma. T2 - A case report. AU - Akiyama, H.. AU - Shidahara, K.. AU - Nasu, Yasutomo. AU - Tsushima, T.. AU - Ohmori, H.. PY - 1995. Y1 - 1995. N2 - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. total nephrectomy was performed. A pathological diagnosis of renal oncocytoma was made. Renal oncocytoma is a rare benign renal tumor. We herein discuss 87 cases of renal oncocytoma which have been reported in Japan.. AB - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. ...
TY - JOUR. T1 - The impact of histology on survival for patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy. AU - Carrasco, Alonso. AU - Thompson, R. Houston. AU - Leibovich, Bradley C.. AU - Lohse, Christine M.. AU - Cheville, John C.. AU - Boorjian, Stephen A.. PY - 2014. Y1 - 2014. N2 - Objective: To evaluate the impact of histology on cancer-specific and overall survival for patients with metastatic renal cell carcinoma (mRCC) undergoing cytoreductive nephrectomy (CN). Materials and Methods: We retrospectively reviewed the data of 505 patients with mRCC who underwent CN at Mayo Clinic, Rochester, MN, USA, between 1970 and 2008. All specimen were re-reviewed by a single genitourinary pathologist. Survival was estimated using the Kaplan-Meier method and compared according to histology with the log-rank test. Cox proportional hazard regression models were used to evaluate the association of histology with outcome. Results: Forty (8%) patients with non-clear cell ...
TY - JOUR. T1 - Kidney size and cancer-specific survival for patients undergoing nephrectomy for pT1 clear cell renal cell carcinoma. AU - Jorns, Jacob J.. AU - Thiel, David D.. AU - Lohse, Christine. AU - Williams, Adrienne. AU - Arnold, Michelle. AU - Cheville, John. AU - Leibovich, Bradley. AU - Parker, Alexander S.. PY - 2012/7/1. Y1 - 2012/7/1. N2 - Objective: To examine the association between kidney size and renal cell carcinoma (RCC) death among patients with Stage pT1 clear cell RCC undergoing surgery. Methods: We used a case-cohort design and evaluated 191 patients from our Nephrectomy Registry who had undergone open radical nephrectomy for unilateral, sporadic, Stage pT1N0/NxM0, noncystic clear cell RCC from 1989 to 2004. Of these, 47 patients died of RCC (cases) and 144 patients were alive at the last follow-up visit or had died of other causes (cohort). Univariate and multivariate associations with RCC death were evaluated using weighted Cox regression analysis and summarized ...
Sumanta Pal, MD of City of Hope, Duarte, CA, discusses the introduction of new data of the new single-agent cabozantinib for advanced renal cell carcinoma. The agent is a dual MET and VEGFR2 inhibitor, and has been assessed in metastatic renal cell carcinoma and other diseases. Dr Pal highlights his involvement in the Phase I trials of cabozantinibs development in renal cell carcinoma, where impressive responses were observed. He proceeds to highlight that most recently, cabozantinib was used in a Phase III METEOR trial comparing it to the agent everolimus (NCT01865747). This study identified an improvement in response rate, overall survival (OS) and progression-free survival (PFS) for patients with advanced renal cell carcinoma. According to Dr Pal, these findings make the agent the optimal second-line choice in patients with metastatic renal cell carcinoma. He further adds that data from the CABOSUN study (NCT01835158), a clinical trial that compared sunitinib and cabozantinib in the front-line
TY - JOUR. T1 - Alterations in chromatin accessibility and DNA methylation in clear cell renal cell carcinoma. AU - Buck, M. J.. AU - Raaijmakers, L. M.. AU - Ramakrishnan, S.. AU - Wang, D.. AU - Valiyaparambil, S.. AU - Liu, S.. AU - Nowak, N. J.. AU - Pili, Roberto. PY - 2014/10/9. Y1 - 2014/10/9. N2 - Recent studies have demonstrated that in clear cell renal cell carcinoma (ccRCC) several chromatin remodeling enzymes are genetically inactivated. Although, growing evidence in cancer models has demonstrated the importance of epigenetic changes, currently only changes in DNA methylation can be accurately determined from clinical samples. To address this limitation, we have applied formaldehyde-assisted isolation of regulatory elements (FAIREs) combined with next-generation sequencing (FAIRE-seq) to identify specific changes in chromatin accessibility in clinical samples of ccRCC. We modified the FAIRE procedure to allow us to examine chromatin accessibility for small samples of solid tumors. ...
Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405 Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405
Metachronous renal cell carcinoma after radical nephrectomy is extremely rare. Renal cell carcinoma commonly metastasizes to distant organs. However, metastasis to the urinary bladder is very uncommon. Herein, we report a case of metachronous renal cell carcinoma with metastasis to the urinary bladder, left acetabulum, left rib, lungs, thyroid, right renal vein and inferior vena cava. The patient had undergone a left-sided radical nephrectomy 28 years ago. The pathological diagnosis of a fragment of the bladder tumor was consistent with Fuhrman grade 2 clear cell renal cell carcinoma. Although metachronous renal cell carcinoma after radical nephrectomy is rare, active surveillance should be still considered. Renal cell carcinoma has shown to unusually metastasize to the urinary bladder, a rarely reported organ of metastasis. Treatment options, such as immunotherapy, are available to patients with such metastasis and long-term survivorship can be achieved.
TY - JOUR. T1 - Cloning of renal cell carcinoma relation gene. T2 - Construction of a cDNA subtractive library of human renal cell carcinoma and its significance. AU - Zhang, Qiang. AU - Mao, Ze Bin. AU - Zhang, Zhi Wen. AU - Xin, Dian Qi. AU - Guo, Ying Lu. PY - 2000/12/1. Y1 - 2000/12/1. N2 - To construct a cDNA subtractive library of human renal cell carcinoma (RCC) with technique called suppression subtractive hybridization. The library only contains the differently expressing cDNAs between RCC and normal kidney. Poly (A)+ RNA were isolated from cell lines of RCC and normal kidney respectively. Moreover, single-strand cDNAs and double-strand cDNAs were synthesized in turn. After enzyme restriction, cDNAs between 400600 bp were obtained. RCC cDNAs then were divided into two groups and ligated to the specific adaptor 1 and adaptor 2 respectively . After RCC cDNAs hybridized with normal kidney cDNA twice and underwent two times of nested PCR, then with arms of T/A plasmid vectors to set up the ...
Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the cBioPortal database, respectively. IRGs were obtained from the ImmPort database. We analyzed the expression of IRGs in ccRCC, and discovered 681 that were differentially expressed between ccRCC and normal kidney tissues. Univariate Cox regression analysis was used to identify prognostic differentially expressed IRGs (PDEIRGs). Using Lasso regression and multivariate Cox regression analyses, we detected seven optimal PDEIRGs (PLAU, ISG15, IRF9, ARG2, RNASE2, SEMA3G and UCN) and used them to construct a risk model to predict the prognosis of ccRCC patients. This model accurately stratified patients with different survival outcomes and
List of Tables. Table 1: Clinical subtypes of Indication. Table 2: Risk Factors. Table 3: Prevalence cases (%) Region wise. Table 4: Sources used for forecasting the data. Table 5: Renal cell carcinoma Global Epidemiology, (2013-2023). Table 6: Prevalent Cases of Renal cell carcinoma (Ages =XX Years), US (2013-2023). Table 7: Prevalent Cases of Renal cell carcinoma By Sex (Males & Females), US (2013-2023). Table 8: Prevalent Cases By Renal cell carcinoma Sub-population, US (2013-2023). Table 9: Prevalent Cases of Renal cell carcinoma (Ages =XX Years), United Kingdom (2013-2023). Table 10: Prevalent Cases of Renal cell carcinoma By Sex (Males & Females), United Kingdom (2013-2023). Table 11: Prevalent Cases By Renal cell carcinoma Sub-population, United Kingdom (2013-2023). Table 12: Prevalent Cases of Renal cell carcinoma (Ages =XX Years), Germany (2013-2023). Table 13: Prevalent Cases of Renal cell carcinoma By Sex (Males & Females), Germany (2013-2023). Table 14: Prevalent Cases By Renal cell ...
Advanced Renal Cell Carcinoma (RCC) Market Research Report present a detailed analysis of the market listing Advanced Renal Cell Carcinoma (RCC) Epidemiology, Drug therapies and pipeline for study period from 2018-2030.
TY - JOUR. T1 - Intra-renal splenosis mimicking a solid renal mass. AU - Neufeld, Ethan A.. AU - Sekhon, Simran. AU - Gerscovich, Eugenio O. PY - 2017/8/1. Y1 - 2017/8/1. N2 - We present the case of a young woman found to have an exophytic solid renal mass who was referred to our institution for ablation of said mass versus partial nephrectomy. The patient had a history of splenectomy. Ultrasound demonstrated a homogeneous solid left renal mass, and the diagnosis of intra-renal splenosis was considered based on the patients history. The diagnosis was confirmed using Tc-99 m heat-damaged red blood cell scintigraphy, obviating the need for an invasive procedure. The diagnosis of intra-renal splenosis should be considered for a solid renal mass with an appropriate history of prior splenic trauma or splenectomy.. AB - We present the case of a young woman found to have an exophytic solid renal mass who was referred to our institution for ablation of said mass versus partial nephrectomy. The patient ...
Adding chemical shift techniques to MRI can help differentiate clear cell renal cell carcinoma from other types of renal cell cancer, a new study shows. That differentiation can help physicians better determine treatment for these patients.. The study, conducted at Massachusetts General Hospital in Boston, included 156 patients with proven renal cell cancer. Clear cell renal carcinoma contains microscopic areas of fat, which is not seen on conventional imaging, said Dr. Azadeh Elmi, lead author of the study. Chemical shift MRI enables us to quantify even small amounts of fat, she said. The study found that chemical shift MRI was about 83% accurate in differentiating clear cell renal cell carcinoma from other types of kidney cancer.. Clear cell type is the most common type of kidney cancer, and it has the greatest potential to metastasize, said Dr. Elmi. Chemical shift MRI is a protocol that can be readily performed in kidney MRI at no additional cost, she said. As we are moving toward less ...
BACKGROUND: The use of cytoreductive nephrectomy (CN) selectively for patients who show a favorable response to upfront systemic therapy may be an approach to select optimal candidates with metastatic renal cell carcinoma (mRCC) who are most likely to benefit.. OBJECTIVE: We sought to characterize outcomes of deferred CN (dCN) after upfront sunitinib, outcomes relative to sunitinib alone, and outcomes of CN followed by sunitinib.. DESIGN, SETTING, AND PARTICIPANTS: We used the prospectively maintained International mRCC Database Consortium (IMDC) database to identify patients with newly diagnosed mRCC (2006-2018).. INTERVENTION: Sunitinib alone, upfront CN followed by sunitinib, sunitinib followed by dCN.. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Outcomes were overall survival (OS) and time to sunitinib treatment failure (TTF). Kaplan-Meier and multivariable Cox regression analyses were performed; dCN was analyzed as a time-varying covariate to account for immortal time bias.. RESULTS AND ...
Full Text - In this study, we performed bioinformatics and statistical analyses to investigate the prognostic significance of metabolic genes in clear cell renal cell carcinoma (ccRCC) using the transcriptome data of 539 ccRCC and 72 normal renal tissues from TCGA database. We identified 79 upregulated and 45 downregulated (n=124) metabolic genes in ccRCC tissues. Eleven prognostic metabolic genes (NOS1, ALAD, ALDH3B2, ACADM, ITPKA, IMPDH1, SCD5, FADS2, ACHE, CA4, and HK3) were identified by further analysis. We then constructed an 11-metabolic gene signature-based prognostic risk score model and classified ccRCC patients into high- and low-risk groups. Overall survival (OS) among the high-risk ccRCC patients was significantly shorter than among the low-risk ccRCC patients. Receiver operating characteristic (ROC) curve analysis of the prognostic risk score model showed that the areas under the ROC curve for the 1-, 3-, and 5-year OS were 0.810, 0.738, and 0.771, respectively. Thus, our prognostic
Clinical trial for Renal Cell Carcinoma | urinary tract cancer | Bladder Urothelial Carcinoma | Transitional Cell Carcinoma of the Bladder | Metastatic Kidney Carcinoma | clear cell renal cell carcinoma | Malignant Adenoma | Stage IV Renal Cell Cancer AJCC v8 | Adenocarcinoma | transitional cell carcinoma of bladder | Malignant neoplasm of kidney | Renal Cancer | Urologic Cancer | Renal Cell Cancer | Malignant Neoplasms of Urinary Tract | Kidney Cancer | urinary tract neoplasm , Daratumumab in Treating Patients With Muscle Invasive Bladder Cancer or Metastatic Kidney Cancer
1. Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. Lancet. 2009;373:1119-32 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA: a cancer journal for clinicians. 2019;69:7-34 3. Campbell S, Uzzo RG, Allaf ME, Bass EB, Cadeddu JA, Chang A. et al. Renal Mass and Localized Renal Cancer: AUA Guideline. The Journal of urology. 2017;198:520-9 4. Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M. et al. EAU guidelines on renal cell carcinoma: 2014 update. European urology. 2015;67:913-24 5. Capitanio U, Montorsi F. Renal cancer. Lancet. 2016;387:894-906 6. Van Poppel H, Da Pozzo L, Albrecht W, Matveev V, Bono A, Borkowski A. et al. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. European urology. 2011;59:543-52 7. Crispen PL, Breau RH, Allmer C, Lohse CM, Cheville JC, Leibovich BC. et al. Lymph node dissection at the time of radical ...
Through combined deletion of Vhl, Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates the cellular and molecular features of a large proportion of human tumors. This model uncovers a role for primary-cilium-related genes in the development of the disease and provides a reliable platform for preclinical therapeutic studies. Clear cell renal cell carcinomas (ccRCCs) frequently exhibit inactivation of the von Hippel-Lindau tumor-suppressor gene, VHL, and often harbor multiple copy-number alterations in genes that regulate cell cycle progression. We show here that modeling these genetic alterations by combined deletion of Vhl, Trp53 and Rb1 specifically in renal epithelial cells in mice caused ccRCC. These tumors arose from proximal tubule epithelial cells and shared molecular markers and mRNA expression profiles with human ccRCC. Exome sequencing revealed that mouse and human ccRCCs exhibit recurrent mutations in genes associated with
ABSTRACT. Cell cycle regulation in human renal cell carcinoma. Ylva Hedberg, Departments of Medical Biosciences, Pathology, and Surgical and. Perioperative Sciences, Urology Andrology, Umeå University, Sweden. Deregulated growth control is a hallmark of neoplasia potentially caused by aberrant expression of cell cycle regulatory proteins. The importance of such aberrations in human renal cell carcinoma (RCC) has not been fully clarified. Therefore, the protein expressions of several G1/S regulatory proteins in human RCC were evaluated and their relation to clinico-pathological data was examined.. Western blotting and immunohistochemistry were used to detect the proteinexpression of cyclin D1, D3, and E in 80 RCCs. Most tumors expressed higher levels of cyclin D1 (75%) and cyclin E (65%) compared to corresponding normal kidney cortex. In contrast, only 16 % of the tumors had high levels of cyclin D3. In conventional RCCs, low levels of cyclin D1 were associated with large tumor size, aneuploidy ...
Objective: Our study aims to investigate the mechanism of the miR-129-5p/SPN axis in clear cell renal cell carcinoma (ccRCC), providing a novel direction for the targeted therapy of ccRCC. Methods: Bioinformatics methods were implemented to find the dif...
BACKGROUND: The prognostic value of cyclooxygenase-2 (COX-2) in human renal cell carcinoma (RCC) remains unclear. The purposes of this study are to elucidate the clinical significance of COX-2 in clear cell RCC (CCRCC) and to assess the treatment effect of COX-2 inhibition on CCRCC cell lines. METHODS: Using tumor samples obtained from 137 patients who had undergone nephrectomy at Seoul National University Hospital, we evaluated COX-2 expression on immunohistochemistry. Moreover, we performed the cell proliferation assay using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) and cell invasion assay. Thus, we evaluated the effect of meloxicam, an inhibitor of COX-2, in two human CCRCC cell lines. RESULTS: Cancer-specific survival (p=0.038) and progression-free survival (p=0.031) were shorter in the COX-2 high expression group. A multivariate logistic regression model showed that COX-2 expression was an independent risk factor for pTNM stage and Fuhrman nuclear grade. The MTT ...
TY - JOUR. T1 - Does Obesity Impact the Costs of Partial and Radical Nephrectomy?. AU - Bensalah, Karim. AU - Raman, Jay D.. AU - Bagrodia, Aditya. AU - Marvin, Andrea. AU - Lotan, Yair. PY - 2008/5/1. Y1 - 2008/5/1. N2 - Purpose: We analyzed the impact of obesity on the costs of partial and radical nephrectomy. Materials and Methods: The charts of 237 patients who underwent open radical nephrectomy (48), laparoscopic radical nephrectomy (67), open partial nephrectomy (61) or laparoscopic partial nephrectomy (61) were retrospectively reviewed. Clinical data were collected, including age, American Society of Anesthesiologists score, body mass index, tumor size, complications and length of stay. Cost data comprised total direct costs and subcosts, including anesthesia, laboratory, operating room service, radiology, room and board, pharmacy and surgical supplies. Obese and nonobese patients were compared in each group using the Mann-Whitney U and chi-square tests for continuous and categorical ...
TY - JOUR. T1 - A cohort study of reproductive and hormonal factors and renal cell cancer risk in women. AU - Kabat, G. C.. AU - Navarro Silvera, S. A.. AU - Miller, A. B.. AU - Rohan, T. E.. PY - 2007/3/12. Y1 - 2007/3/12. N2 - We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02-3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had ≥5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR=2.41, 95% CI=1.27-4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal ...
Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel-Lindau (VHL) tumor suppressor. Roles for noncoding cis-regulatory aberrations in ccRCC tumorigenesis, however, remain unclear. Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, with cognate enhancer-target genes associated with tissue-specific aspects of malignancy. Superenhancer profiling identified ZNF395 as a ccRCC-specific and VHL-regulated master regulator whose depletion causes near-complete tumor elimination in vitro and in vivo. VHL loss predominantly drives enhancer/superenhancer deregulation more so than promoters, with acquisition of active enhancer marks (H3K27ac, H3K4me1) near ccRCC hallmark genes. Mechanistically, VHL loss stabilizes HIF2α-HIF1β heterodimer binding at enhancers, subsequently recruiting histone acetyltransferase p300 ...
Preoperative renal tumor subtype differentiation is definitely important for radiology and urology in clinical practice. vs 40.3180.4833 vs 50.0130.1654 vs 5 0.0010.411 Open in a separate window Note: 1: clear cell renal cell carcinoma; 2: papillary renal cell carcinoma; 3: chromophobic renal cell carcinoma; 4: uroepithelial carcinoma; 5: fat-poor angiomyolipoma. Open in a separate window Figure 3 Box-and-whisker plot of em K /em trans value. Boxes?=?interquartile range, whiskers?=?range of all values, horizontal line within box?=?median em K /em trans, ccRCC?=?clear cell RCC, pRCC?=?papillary RCC, cRCC?=?chromophobic RCC, UEC?=?uroepithelial carcinoma, fpAML?=?fat poor angiomyolipoma. Open in a separate window Figure 4 Box-and-whisker plot of em V /em e value. Boxes?=?interquartile range, whiskers?=?range of all values, horizontal line within box?=?median em V /em e, ccRCC?=?clear cell RCC, pRCC?=?papillary RCC, cRCC?=?chromophobic RCC, UEC?=?uroepithelial carcinoma, fpAML?=?fat poor ...
The median age was 57 years (range 30-80). Most patients underwent a nephrectomy (n = 41; 70.7%), were male (n = 42; 72.4%) and had clear-cell (CC) RCC (n = 51; 87.9%). Patients were treated with first-line sunitinib (n = 45; 77.6%) or pazopanib (n = 13; 22.4%). The median time from the initial RCC diagnosis to the diagnosis of BMs was 9 months. The median time from the first occurrence of metastasis to the development of BMs was 7 months. The median overall survival (OS) of mRCC patients with BMs was 13 months. Time from the initial diagnosis of systemic metastasis to the development of BMs (,12 months; p = 0.001), histological subtype (non-CC; p,0.05) and number of BMs (≥2; p,0.05) were significantly associated with OS in multivariate analysis. There were no cases of toxic death. One mRCC patient with BMs (1.7%) experienced treatment-related cerebral necrosis. All other toxicities included those commonly observed with VEGF-TKI therapy.. ...
Bristol-Myers Squibb has announced the early closure of its phase 3 CheckMate-025 trial evaluating nivolumab (Opdivo) compared with everolimus for the treatment of previously-treated patients with advanced or metastatic renal cell carcinoma.. The study was stopped early because an independent Data Monitoring Committee assessment found that nivolumab is superior to everolimus in this patient population.. The results of CheckMate-025 mark the first time an Immuno-Oncology agent has demonstrated a survival advantage in advanced renal cell carcinoma, a patient group that currently has limited treatment options, said Michael Giordano, senior vice president, Head of Development, Oncology, Bristol-Myers Squibb. Through our Opdivo clinical development program, we aim to redefine treatment expectations for patients with advanced RCC by providing improved survival.. For the open-label trial, 821 previously-treated patients with advanced or metastatic clear-cell renal cell carcinoma were randomly ...
Preliminary data from an interim analysis of an ongoing phase III clinical trial of investigational temsirolimus (CCI-779) for the treatment of advanced renal cell carcinoma showed that single-agent therapy with temsirolimus significantly increased overall survival as a first-line treatment of patients with advanced disease and poor-risk features compared to interferon-alpha, a treatment for advanced renal cell carcinoma. In the trial, patients who were treated with temsirolimus alone experienced a 3.6-month, or 49%, increase in median overall survival time compared with patients treated with interferon-alpha alone (10.9 vs 7.3 months, P = .0069). 1
The bevacizumab experience in advanced renal cell carcinoma Lauren C Harshman, Sandy SrinivasDivision of Oncology, Stanford University School of Medicine, Stanford, California, USAAbstract: Bevacizumab in combination with interferon alfa is now approved for treatment-naïve advanced renal cell carcinoma (RCC) in both the US and Europe. Its objective response rates of 30% and progression-free survival rates of 9–10 months are ­comparable to the other approved first-line multityrosine kinase inhibitors, sunitinib and pazopanib. Its advantages include a different toxicity profile and assurance of ­administration compliance given its intravenous formulation. Enthusiasm for its use is blunted by the increased costs, the potential infusion-related reactions, the associated interferon-related toxicities, and the inconvenience of its nonoral formulation. Further study is warranted to assess its efficacy both as a single agent and in combination with the targeted agents and other
Riboflavin (vitamin B2) is a precursor for coenzymes involved in energy production, biosynthesis, detoxification, and electron scavenging. Previously, we demonstrated that irradiated riboflavin (IR)...
Background:It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women.Methods:Information on beverage consumption was obtained from a questionnaire sent 3 years after recruitment into the Million Women Study. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index.Results:After an average of 5.2 years of follow-up, 588 cases of renal cell carcinoma were identified among 779 369 women. While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for 2 vs 1 drink per day: 0.76; 95% CI: 0.61-0.96; P for
This research study is comparing different drug combinations as a possible treatment for metastatic renal cell carcinoma (mRCC) and bone metastases. The names
TY - JOUR. T1 - Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR). T2 - final results from a randomised, open-label, phase 3 trial. AU - Choueiri, Toni K.. AU - Escudier, Bernard. AU - Powles, Thomas. AU - Tannir, Nizar M.. AU - Mainwaring, Paul N.. AU - Rini, Brian I.. AU - Hammers, Hans J.. AU - Donskov, Frede. AU - Roth, Bruce J.. AU - Peltola, Katriina. AU - Lee, Jae Lyun. AU - Heng, Daniel Y C. AU - Schmidinger, Manuela. AU - Agarwal, Neeraj. AU - Sternberg, Cora N.. AU - McDermott, David F.. AU - Aftab, Dana T.. AU - Hessel, Colin. AU - Scheffold, Christian. AU - Schwab, Gisela. AU - Hutson, Thomas E.. AU - Pal, Sumanta. AU - Motzer, Robert J.. AU - METEOR investigators. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Background Cabozantinib is an oral inhibitor of tyrosine kinases including MET, VEGFR, and AXL. The randomised phase 3 METEOR trial compared the efficacy and safety of cabozantinib versus the mTOR inhibitor everolimus in patients with advanced renal cell carcinoma ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The term RCC encompasses a highly heterogeneous group of malignancies, from both a morphological and a molecular point of view, but emerging evidence indicates that common molecular paths to renal carcinogenesis do exist and may justify, to some extent, shared approaches to the clinical treatment of different RCC subtypes (2). Although most of RCC cases occur in a sporadic form, both clear cell and non-clear cell RCC can occur in the context of inherited cancer syndromes, whose molecular genetics has shed light on potentially common molecular pathogenetic themes (3-4). This is probably best exemplified by von Hippel-Lindau disease (VHL) and tuberous sclerosis (TS), two autosomal dominant inherited syndromes with variable penetrance that carry a high lifetime risk of developing clear cell RCC (5-6). The VHL gene, which targets hypoxia inducible factor (HIF)-1α for degradation by the proteasome, is mutated or silenced in up to 75% of sporadic clear cell RCC, suggesting that genetic abnormalities ...
Wang SF, Lo WO «Benign neoplasm of kidney: Angiomyolipoma» (en anglès). J Med Ultrasound, 2018 Jul-Set; 26 (3), pp: 119-122. ... Understanding the kidney one cell at a time (en anglès). Kidney Int, 2019 Oct; 96 (4), pp: 862-870. PMID: 31492507. DOI 10.1016 ... Tanaka, Shinji; Okusa, Mark D. Crosstalk between the nervous system and the kidney (en anglès). Kidney Int, 2020 Mar; 97 (3) , ... Rayner, Hugh C.; Thomas, Mark A.B.; Milford, David V. Kidney Anatomy and Physiology (en anglès). A: Understanding Kidney ...
Kidney Renal cell carcinoma Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of three cases ... It represent 5% to 15% of surgically resected renal neoplasms. Ultrastructurally, the eosinophilic cells have numerous ... A renal oncocytoma is a tumour of the kidney made up of oncocytes, epithelial cells with an excess amount of mitochondria. ... Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. ...
Kidney Renal cell carcinoma Hurthle cell Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of ... It represents 5% to 15% of surgically resected renal neoplasms.[citation needed] The salivary gland oncocytoma is a well- ... Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. ...
... of all kidney neoplasms. Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 ( ... Moreover, patients who experienced chronic kidney diseases or acute kidney injury exhibited a higher incidence of PRCC. ... ISBN 978-1-4377-1958-1. Haas NB, Nathanson KL (January 2014). "Hereditary kidney cancer syndromes". Advances in Chronic Kidney ... "Enhancement characteristics of papillary renal neoplasms revealed on triphasic helical CT of the kidneys". AJR. American ...
Neoplasms - Renal cell carcinoma or liver tumors, von Hippel-Lindau disease, and endocrine abnormalities including ... This reduces oxygen delivery to the kidneys, causing increased erythropoietin production and a resultant polycythemia. ...
Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and ... Rhabdoid tumor, which accounts for 5-10% of childhood kidney neoplasms, occurs predominantly in children from 1 to 2 years of ... Wilms tumor is the most common childhood kidney neoplasm, representing some 85% of cases. Unlike mesoblastic nephroma, 3 years ... This neoplasm is generally non-aggressive and amenable to surgical removal. However, a readily identifiable subset of these ...
The protein encoded by c2orf81 is expressed highly in testis, kidneys, and about 18 other tissues in humans. Disease states in ... which it is expressed include in gliomas, neoplasm, skin tumors, and lymphoma. Only a few mutations have been documented to ...
Comparison of Neoplasms in Six Sources of Rats *^ Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed ... The leading cause of death among fz/fz rats is ultimately a progressive kidney failure that begins around the age of 1 year.[31 ... Shorn rats were bred from Sprague Dawley rats in Connecticut in 1998.[32] They also suffer from severe kidney problems. ... A 1972 study compared neoplasms in Sprague Dawley rats from six different commercial suppliers and found highly significant ...
These tumors, on occasion, may appear similar to neoplasms of renal (relating to the kidneys) origin or other soft tissue ... neoplasms. The primary method for treatment is surgical, not medical. Radiation and chemotherapy are not needed for benign ...
Renal oncocytoma, a kidney tumour composed of oncocytes. Hurthle cell carcinoma, a variant of follicular thyroid carcinoma. ... Oncocytoma, a tumour composed of oncocytes, may be found as a less common salivary gland neoplasm also known as oxyphilic ...
... the overall kidney function may remain normal since the unaffected kidney will compensate for the obstructed kidney.[citation ... In older adults, the most common cause of hydronephrosis is benign prostate hyperplasia (BPH), or intrapelvic neoplasms such as ... kidneys are affected, the pre-existing kidney function, the duration of hydronephrosis (acute or chronic), and whether ... Permanent kidney damage can occur from prolonged hydronephrosis secondary to compression of kidney tissue and ischemia. For ...
A hamartoma is a mostly benign, local malformation of cells that resembles a neoplasm of local tissue but is usually due to an ... Angiomyolipoma of the kidney was previously considered to be a hamartoma or choristoma. A myoepithelial hamartoma, also known ... When seen on upper gastrointestinal series, a pancreatic rest may appear to be a submucosal mass or gastric neoplasm. Most are ... They are particularly likely to cause major health issues when located in the hypothalamus, kidneys, lips, or spleen. They can ...
1990;143(4):813-5. Sameshima N, Marutsuka K, Tsukino H, Kamoto T, Kono S, Asada Y. So-called 'adenosarcoma' of the kidney a ... Malignant neoplasms arising in endometriosis: clinicopathological study of 14 cases. Clin Exp Obstet Gynecol. 2004;31(4):302-4 ... The rare cases of adenosarcoma outside the female genital tract usually occur in the liver, bladder, kidney, as well as the ...
Fuchs R, Machleidt W, Gassen HG (Feb 1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney ... Chernaia VI, Reva AD (1990). "[Cathepsin H activity in the human brain and human brain neoplasms]". Ukr. Biokhim. Zh. 61 (5): ... 1988). "Amino acid sequences of the human kidney cathepsins H and L." FEBS Lett. 228 (2): 341-5. doi:10.1016/0014-5793(88)80028 ...
Comparison of Neoplasms in Six Sources of Rats Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed. ... The leading cause of death among fz/fz rats is ultimately a progressive kidney failure that begins around the age of 1 year. ... They also suffer from severe kidney problems. The Lewis rat was developed by Margaret Lewis from Wistar stock in the early ... The Lewis rat suffers from several spontaneous pathologies: first, they can suffer from high incidences of neoplasms, with the ...
1975 Riemann first used ultrasound to examine TSC-affected kidneys in the case of a 35-year-old woman with chronic renal ... 1976 Cranial computed tomography (CT, invented 1972) proved to be an excellent tool for diagnosing cerebral neoplasms in ... In addition, whitish hard masses, one "the size of a walnut", were found in both kidneys. 1881 German physician Hartdegen ... 1997 The PKD1 gene, which leads to autosomal dominant polycystic kidney disease (ADPKD), and the TSC2 gene were discovered to ...
... is a rare tumour of the kidney. By 2017 about 25 cases have been reported. This tumour occurs in ... A rare unique renal neoplasm. Int J Surg Pathol 24(6):556-561 Wu MK, Vujanic GM, Fahiminiya S, Watanabe N, Thorner PS, ... Pediatr Int 55(5):e129-132 Labanaris A, Zugor V, Smiszek R, Nützel R, Kühn R (2009) Anaplastic sarcoma of the kidney. ... Hum Pathol 53:114-120 Vujanić GM, Kelsey A, Perlman EJ, Sandstedt B, Beckwith JB (2007) Anaplastic sarcoma of the kidney: a ...
In adulthood, kidney and lung problems may develop. An individual may also be diagnosed at any time as a result of genetic ... Between 60 and 80% of TSC patients have benign tumors (once thought hamartomatous, but now considered true neoplasms) of the ... Removal of the kidney (nephrectomy) is strongly to be avoided. An asymptomatic angiomyolipoma that is growing larger than 3 cm ... Scan the abdomen for tumours in various organs, but most importantly angiomyolipomata in the kidneys. MRI is superior to CT or ...
Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys are the carcinomas that most commonly metastasize to bone. ... Some benign tumors are not true neoplasms, but rather, represent hamartomas, namely the osteochondroma. The most common ...
Gore RM, Shelhamer RP (October 2007). "Biliary tract neoplasms: diagnosis and staging". Cancer Imaging. 7 Spec No A (Special ... "Definition & Facts for Gallstones , NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2020-04 ...
One of the most noted features of OGS is the increased risk of neoplasms in certain OGSs. SGBS in particular has been found to ... Vertebral segmentation defects Supernumerary nipples Structural and conductive cardiac defects Multicystic dysplastic kidneys ... Macrosomia Macroglossia Advanced bone age Organomegaly Neonatal hypoglycemia Neoplasms Congenital diaphragmatic hernia ( ...
... cosegregation of kidney neoplasms with BHD cutaneous lesions was observed in 3 families with a family history of kidney tumors ... mTOR activation was seen in the highly cystic kidneys that developed in mice with kidney-targeted inactivation of Flcn. ... 2008). "Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia". PLOS ONE. 3 (10): ... In BHD-associated kidney tumors, the inherited FLCN gene with a germline mutation is present in all cells, but the remaining ...
It is found on the surface of cells in the airways (such as the lungs) and kidneys. Scientists may be able to use this to their ... with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. A class of oral ... Animal studies suggest its pathogenetic role in development of fibrosis of various organs, such as liver and kidney. CD26/DPPIV ...
... kidney cancer, esophageal cancer as well as head and neck cancer. Besides those, reduced CK1δ activity owing to the site N172D ... hematopoietic malignancies and lymphoid neoplasms. Also decreased CK1δ mRNA expression levels have been observed in some cancer ... kidney cancer, lung adenocarcinoma, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, ...
Shaw JA, Shetty P, Burns KD, Fergusson D, Knoll GA (2015). "C-peptide as a Therapy for Kidney Disease: A Systematic Review and ... C-peptide may be used for determining the possibility of gastrinomas associated with Multiple Endocrine Neoplasm syndromes (MEN ... Therapeutic use of C-peptide has been explored in small clinical trials in diabetic kidney disease. Creative Peptides, Eli ... doi:10.1007/s13410-013-0113-7. Brunskill NJ (January 2017). "C-peptide and diabetic kidney disease". Journal of Internal ...
... also known as neoplasms) located in various organs of the human body, including but not limited to the liver, kidneys, lungs, ... 1990s - Treatment of bone and kidney tumors by embolization. 1990s - RFA for soft tissue tumors, i.e., bone, breast, kidney, ... 14mDY Kidney cancer: kidney tumors such as renal cell carcinoma can be treated with image guided ablation (RFA, MWA, ... Benign kidney tumors such as angiomyolipomas can be treated with transarterial embolization to shrink the tumor size and reduce ...
... kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, ... lung squamous cell carcinoma, lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma ...
Campbell, SC; Novick AC; Bukowski RM (2007). Campbell-Walsh Urology (ed.). Neoplasms of the upper urinary tract (9 ed.). ... 2017 "Polycystic Kidney Disease." American Kidney Fund, www.kidneyfund.org/kidney-disease/other-kidney-conditions/polycystic- ... Another example of cystic kidney disease is Medullary sponge kidney. Cystic kidney disease includes various conditions related ... the other kidney is usually healthy. Cystic dysplasia - can affect one or both kidneys Autosomal recessive polycystic kidney ...
... neoplasm located in either bladder or kidneys pathways. If urine looks dark yellow or similar to orange color, the causative ... ultrasound for kidneys and bladder, urinalysis, urine culture for infection, and cystoscopy. Doctor may also ask for the ...
Here he explains two dominant types of testicular neoplasms. In regards to surgery for testicular cancer, he doubted the ... Anatomical exploration of surgical lesions of the kidney via ureteral retrograde pyelography. Cours de Clinique urologique ... a pioneer of the study and therapy of testicular neoplasms". J BUON. 8: 185-90. PMID 17472251. New Orleans medical and surgical ... a pioneer of the study and therapy of testicular neoplasms". J BUON. 8: 185-90. PMID 17472251. Biographies - BIU Santé, Paris ...
kidney epithelium development. • regulation of transcription, DNA-templated. • positive regulation of metanephric DCT cell ... aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present ... kidney development. • pronephric field specification. • positive regulation of mesenchymal to epithelial transition involved in ... Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus.[7] Additionally, PAX8 is ...
Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. ... kidney cancer, and colon cancer (in decreasing order of frequency). ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ...
2005). "Assessment of JC polyoma virus in colon neoplasms". Dis. Colon. Rectum. 48 (1): 86-91. doi:10.1007/s10350-004-0737-2. ... and can also infect the tubular epithelial cells in the kidneys,[7] where it continues to reproduce, shedding virus particles ...
Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow. ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Eye_neoplasm&oldid=895356793" ...
"Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative ... and excretion by the kidneys with accumulation in the bladder. ...
... deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... Also, bone marrow depression (inducing leukopenia and thrombocytopenia) and acute kidney and liver failure have been reported. ... especially liver and kidneys, eggs, and some seafood.[8][71][72][73] Folate naturally found in food is susceptible to high heat ...
ISBN 0-7020-2606-9. Huete-Garin, A.; S.S. Sagel (2005). "Chapter 6: "Mediastinum", Thymic Neoplasm". In J.K.T. Lee; S.S. Sagel ... A fully functional thymus derived from reprogrammed mouse embryonic fibroblasts has been grown in the kidney capsule of mice. ...
Neoplasm CD34[1] Stromelysin-3[10] Factor XIIIa[6] Dermatofibroma - + + Dermatofibrosarcoma protuberans + - - ...
In obstetrics and gynecology contexts, it is a form of adenomyosis that forms a mass or growth around the tissue of the inner uterus. Most cases of adenomyosis are non-symptomatic. However, it may present with dysmenorrhea and pelvic pain. In the case of juvenile cystic adenomyoma, laparoscopic enucleation results in a statistically and clinically significant reduction in dysmenorrhea, ease in any chronic pelvic pain, and low risk of recurrence.[2] ...
This ranges from arteries serving the brain to those bringing blood to the lungs, kidneys, arms and legs. An example of this ... superior information as compared to CT scans when seeking information about headache to confirm a diagnosis of neoplasm, ... For moderate kidney failure, the use of iodinated contrast should be avoided; this may mean using an alternative technique ... People with mild kidney impairment are usually advised to ensure full hydration for several hours before and after the ...
The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... kidney cancer, and colon cancer (in decreasing order of frequency). ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ...
Brenner and Rector's The Kidney: Volume 8. *^ Gertz (Dec 2014). "Immunoglobulin light chain amyloidosis: 2014 update on ... Bernatsky S, Clarke AE, Suissa S (February 2008). "Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis ... Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications ... Kidney International. 61 (4): 1495-501. doi:10.1046/j.1523-1755.2002.00279.x. PMID 11918757.. ...
en:Kidney cancer (17) → 신장암 *en:Kidney transplantation (29). *en:Knee replacement (7) ... en:Neoplasm (40) → 신생물 *en:Nephrotic syndrome (38) → 신증후군 *en:Nervous system disease (4) ...
Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... and kidneys.[22] About 10% of people with lung cancer do not have symptoms at diagnosis; these cancers are incidentally found ... "Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review and Update". Int J Clin Exp Pathol. 1 (1): 19 ...
... kidney, pancreas stomach and lung. FABP1 is unique in the wider range of other hydrophobic ligands it can bind including ... a marker for studying cellular differentiation in gut epithelial neoplasms". Gastroenterology. 99 (6): 1727-35. PMID 1699834. ... "Clinical usefulness of urinary liver-type fatty-acid-binding protein as a perioperative marker of acute kidney injury in ...
Neoplasms - Renal cell carcinoma or liver tumors, von Hippel-Lindau disease, and endocrine abnormalities including ... This reduces oxygen delivery to the kidneys, causing increased erythropoietin production and a resultant polycythemia. ...
Renal vein thrombosis (thrombosis of the veins of the kidneys. Parodoxical embolism[edit]. Systemic embolism of venous origin ... Myeloproliferative neoplasms including essential thrombocytosis and polycythemia vera[8]. *Chemotherapy[7][19] ...
Acquired cystic kidney disease-associated renal cell carcinoma. *Acquired generalized lipodystrophy. *Acquired non-inflammatory ... Adipose tissue neoplasm. *Adiposis dolorosa. *Adiposogenital dystrophy. *Adipsia. *Adjustment disorder. *Adnexal and skin ...
"GATA1 Expression in BCR/ABL1-negative Myeloproliferative Neoplasms". Annals of Laboratory Medicine. 38 (4): 296-305. doi: ... and skin plus secondarily life-threatening damage to the lungs and kidneys. These same individuals can develop secondary ... "Spectrum of myeloid neoplasms and immune deficiency associated with germline GATA2 mutations". Cancer Medicine. 4 (4): 490-9. ...
Right and left kidneys.. The front border of the liver has been lifted up (brown arrow).[3] ... "Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases". HPB. 8 (2): 148-50. doi:10.1080/ ... and sits between the layers of the ligament between the spleen and the left kidney. The splenic vein, which also passes behind ...
Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... and that acitretin taken by mouth may have a skin protective benefit in people following kidney transplant.[47] ... Tumors: Skin neoplasm, nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799) ...
This implicates RET signal transduction as key to the development of normal kidneys and the enteric nervous system.[9] ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ... Mice deficient in GDNF, GFRα1 or the RET protein itself exhibit severe defects in kidney and enteric nervous system development ...
Kidney cancer is by far the most common cancer to spread to the pancreas, followed by colorectal cancer, and then cancers of ... "Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Pancreatic mucinous cystic neoplasms are a broad group of pancreas tumors that have varying malignant potential. They are being ... The third type, pancreatic mucinous cystic neoplasms (MCNs) mainly occur in women, and may remain benign or progress to cancer. ...
KidneysEdit. Kidney damage occurs with exposure to high levels of lead, and evidence suggests that lower levels can damage ... neoplasms of the central nervous system, emotional and behavior disorders, and intellectual disability.[23] ... Outcome is related to the extent and duration of lead exposure.[201] Effects of lead on the physiology of the kidneys and blood ... Wright, LF; Saylor, RP; Cecere, FA (1984). "Occult lead intoxication in patients with gout and kidney disease". The Journal of ...
... does not apply automatic mapping of the term in the following circumstances: by writing the quoted phrase (e.g., "kidney ... ", "breast cancer" to "breast neoplasms". Where appropriate, these MeSH terms are automatically "expanded", that is, include ... allograft"), when truncated on the asterisk (e.g., kidney allograft*), and when looking with field labels (e.g., Cancer [ti]).[ ...
Kidney: JGA (renin) · peritubular cells (EPO) · calcitriol · prostaglandin Heart: Natriuretic peptide (ANP, BNP) ...
... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... and kidney.[68] Further clonal expansions have been observed in the stomach,[69] bladder,[70] colon,[71] lung,[72] ... The Hallmarks of Cancer as evolutionary adaptations in a neoplasm[edit]. In their landmark paper, The Hallmarks of Cancer,[3] ... Cells in neoplasms compete for resources, such as oxygen and glucose, as well as space. Thus, a cell that acquires a mutation ...
Acute kidney failure prior to chemotherapy. Since the major cause of acute kidney failure in this setting is uric acid build-up ... TLS is most common during cytotoxic treatment of hematologic neoplasms.[7] ... Acute kidney failure after chemotherapy. The major cause of acute kidney failure in this setting is hyperphosphatemia, and the ... Acute uric acid nephropathy (AUAN) due to hyperuricosuria has been a dominant cause of acute kidney failure but with the advent ...
Cancers, Kidney. All MeSH CategoriesDiseases CategoryNeoplasmsNeoplasms by SiteUrogenital NeoplasmsUrologic NeoplasmsKidney ... All MeSH CategoriesDiseases CategoryMale Urogenital DiseasesUrogenital NeoplasmsUrologic NeoplasmsKidney NeoplasmsCarcinoma, ... All MeSH CategoriesDiseases CategoryMale Urogenital DiseasesUrologic DiseasesKidney DiseasesKidney NeoplasmsCarcinoma, Renal ... Urogenital Diseases and Pregnancy ComplicationsFemale Urogenital DiseasesUrogenital NeoplasmsUrologic NeoplasmsKidney Neoplasms ...
Kidney NeoplasmsStudy of the Safety and Efficacy of SU-011,248 in Adult Patients With Advanced Kidney Cancer NCT00054886 ... Kidney Neoplasms Intervention ICMJE *Drug: Axitinib (AG-013736) axitinib will be given at a starting dose of 5 mg BID with ... Kidney NeoplasmsAxitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer NCT00678392 ... Kidney NeoplasmsAnti-angiogenesis Agent AG-013736 in Patients With Metastatic Renal Cell Carcinoma NCT00076011 ...
Kidney NeoplasmsStudy of the Safety and Efficacy of SU-011,248 in Adult Patients With Advanced Kidney Cancer NCT00054886 ... Kidney NeoplasmsTreatment Patterns With Targeted Therapies In Mrcc In Sweden - A Retrospective Analysis Of Data From National ... Kidney NeoplasmsAxitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer NCT00678392 ... Kidney NeoplasmsAxitinib (AG-013736) For the Treatment of Metastatic Renal Cell Cancer NCT00920816 ...
Histological typing of kidney tumours / F. K. Mostofi, in collaboration with I. A. Sesterhenn, L. H. Sobin and pathologists in ...
Neoplasms, Kidney Completed Phase 3 Trials for Sorafenib (DB00398). Back to Neoplasms, Kidney ...
Neoplasms, Kidney Terminated Phase 1 Trials for Varlilumab (DB11930). Back to Neoplasms, Kidney ...
Herein, we present a case of anaplastic sarcoma of the kidney in a 3-year-old female, who presented ... ... Anaplastic sarcoma of the kidney (ASK) is an extremely rare tumor, which usually presents as a large renal mass. ... item_headline "kidney cancer" @item_description (trial,trials). this searches for the phrase kidney cancer in the title as ... Kidney transplant patient with Kaposi sarcoma in the left foot.. Authors: González-Vilas D, Monteagudo B, González-Martín C, ...
ICD-9 code V10.52 for Personal history of malignant neoplasm of kidney is a medical classification as listed by WHO under the ... Personal history of malignant neoplasm of kidney (V10.52). ICD-9 code V10.52 for Personal history of malignant neoplasm of ... kidney is a medical classification as listed by WHO under the range -PERSONS WITH POTENTIAL HEALTH HAZARDS RELATED TO PERSONAL ...
... will it take over my kidney? Answered by Dr. Devon Webster: Non-cancerous growth: Benign means non-cancerous, and neoplasm ... what does benign neoplasm kidney mean? does it have to come out? ... Neoplasm of uncertin behavior of kidney. Malignant neoplasm of ... neoplasm kidney. A 40-year-old member asked:. what does benign neoplasm kidney mean? does it have to come out? will it take ... Benign means non-cancerous, and neoplasm means new growth. So you have a growth on your kidney that is not cancerous. If this ...
Malignant neoplasm of gallbladder , Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery ... Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Brief description of study. *It has been shown that ... Patients with chronic kidney disease, or allergic to any anesthetic agents used in the study (e.g., desflurane, sevoflurane, ... sevoflurane in terms of the association with postoperative acute kidney injury (AKI) after liver resection surgery. 3. ...
Kidney neoplasms Tier 1 H384. Predesigned 384-well panel for use with SYBR® Green ...
Devon Webster answered: Non-cancerous growth: Benign means non-cancerous, and neoplasm means new growth. So you have a growt ... what does benign neoplasm kidney mean? does it have to come out? will it take over my kidney?. 1 doctor answer • 1 doctor ... But a benign neoplasm does not need to come out, unless it grows over time. And no, it wont take over your kidney! (now ... Benign means non-cancerous, and neoplasm means new growth. So you have a growth on your kidney that is not cancerous. If this ...
Large Multicystic Dysplastic Kidney Mimicking a Large Cystic Renal Neoplasm. PD03-PD04 ... Multicystic Dysplastic Kidney (MCDK) is one of the most common renal conditions seen in paediatric population. The natural ... Management is conservative and surgery is done for selected patients with symptomatic cysts or suspicion of neoplasm. We ... hypertensive child presenting with a large abdominal mass increasing in size with imaging features similar to cystic neoplasm ...
Use SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!
ESD for gastric epithelial neoplasms can be performed in stage 3 CKD patients with comparable efficacy and safety to that ... Outcomes of Endoscopic Submucosal Dissection for Gastric Epithelial Neoplasm in Chronic Kidney Disease Patients: Propensity ... Outcomes of Endoscopic Submucosal Dissection for Gastric Epithelial Neoplasm in Chronic Kidney Disease Patients: Propensity ... Outcomes of Endoscopic Submucosal Dissection for Gastric Epithelial Neoplasm in Chronic Kidney Disease Patients: Propensity ...
Benign neoplasm of unspecified kidney. 2016 2017 2018 2019 Billable/Specific Code *D30.00 is a billable/specific ICD-10-CM code ... Benign neoplasm of kidney. 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes*benign carcinoid tumor of the ... Oncocytoma of kidney. ICD-10-CM D30.00 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0): *656 Kidney and ureter ... Malignant neoplasm of ectopic tissue. *Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ...
Tag: Neoplasm metastasis. Outcomes Following Complete Surgical Metastasectomy for Patients with Metastatic Renal Cell Carcinoma ... EAU Edu Platform highlights the best curated content in kidney cancer varying from scientific publications to practical tools ...
Histological typing of kidney tumours / F. K. Mostofi, in collaboration with I. A. Sesterhenn, L. H. Sobin and pathologists in ... Tumors of the kidney and urinary tract : color atlas and textbook / Steen Olsen.. by Olsen, Steen ... Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances. by IARC Working Group ... Species differences in thryroid, kidney and urinary bladder carcinogenesis / edited by C. C. Capen ... [et al.]. by Capen, C. C ...
Cancer of Kidney; Kidney Cancer; Renal Cancer. On-line free medical diagnosis assistant. Ranked list of possible diseases from ... keywords = neoplasm. (Clic here for more details about this article) 4/886. Metanephric adenoma-like tumors of the kidney: ... Metanephric adenoma of the kidney. BACKGROUND: Metanephric adenoma is a rare renal neoplasm that is histologically and ... keywords = neoplasm. (Clic here for more details about this article) 5/886. Subcapsular hemorrhage of adult Wilms tumor. Wilms ...
Kidney Neoplasms - radiography Kidney Neoplasms - diagnosis Kidney Neoplasms - therapy Kidney Neoplasms - pathology ISBN. ... Genital Neoplasms, Male - pathology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Prostatic Neoplasms - genetics ... Kidney Neoplasms - genetics Kidney Neoplasms - pathology Urologic Neoplasms - genetics Urologic Neoplasms - pathology Prostatic ... Urologic Neoplasms - pathology Kidney Neoplasms - pathology Bladder Neoplasms - pathology ISBN. 1881041883 Language. English ...
Short Description: Benign neoplasm kidney Long Description: Benign neoplasm of kidney, except pelvis This is the 2014 version ... Neoplasms (140-239) * Benign neoplasms (210-229) *223 Benign neoplasm of kidney and other urinary organs ... If your kidneys fail completely, a kidney transplant or dialysis can replace the work your kidneys normally do. ... D30.00 - Benign neoplasm of unspecified kidney (approximate) Approximate Flag. The approximate flag is on, indicating that the ...
Kidney Neoplasms -- surgery ✖Remove constraint Subjects: Kidney Neoplasms -- surgery Titles Sarcoma of the kidney: its ... 1. Sarcoma of the kidney: its operative treatment Author(s):. Abbe, Robert, 1851-1928. Publication:. [Philadelphia? : s.n., ... operative treatment ✖Remove constraint Titles: Sarcoma of the kidney: its operative treatment ...
C79.01 Secondary malignant neoplasm of right kidney and renal pelvis C79.02 Secondary malignant neoplasm of left kidney and ... C79.0 Secondary malignant neoplasm of kidney and renal pelvis C79.00 Secondary malignant neoplasm of unspecified kidney and ... Secondary undifferentiated large cell malignant neoplasm of left kidney. *Small cell carcinoma metastatic to bilateral kidneys ... Secondary malignant neoplasm of left kidney and renal pelvis. 2016 2017 2018 Billable/Specific Code *C79.02 is a billable/ ...
Recommendations for the reporting of resected neoplasms of the kidney. Lucien E. Nochomovitz, Sonny L. Johansson, Maria Merino ... Recommendations for the reporting of resected neoplasms of the kidney. Human Pathology. 1996 Jan 1;27(10):1005-1007. ... Recommendations for the reporting of resected neoplasms of the kidney. / Nochomovitz, Lucien E.; Johansson, Sonny L.; Merino, ... title = "Recommendations for the reporting of resected neoplasms of the kidney",. abstract = "The Association of Directors of ...
Start Over You searched for: Subjects Kidney Neoplasms -- diagnostic imaging ✖Remove constraint Subjects: Kidney Neoplasms -- ...
D30.01 is a billable code used to specify a medical diagnosis of benign neoplasm of right kidney. Code valid for the fiscal ... 658 - KIDNEY AND URETER PROCEDURES FOR NEOPLASM WITHOUT CC/MCC. Convert D30.01 to ICD-9. *223.0 - Benign neoplasm kidney ( ... Neoplasms (C00-D48) * Benign neoplasms, except benign neuroendocrine tumors (D10-D36) * Benign neoplasm of urinary organs (D30 ... like benign neoplasm of right kidney or benign tumor of renal parenchyma or oncocytoma of kidney or oncocytoma of right kidney ...
Benign neoplasms. Diabetes. 1.3%. Kidney disease. 1.7%. Hypertension. 1.8%. Influenza and pneumonia. 1.8%. Septicemia. 1.9%. ... Benign neoplasms. In situ neoplasms, benign neoplasms and neoplasms of uncertain or unknown behavior. ... Kidney disease. 2.9%. Kidney disease. 3.1%. 9. Stroke. 1.6%. HIV disease. 2.8%. Chronic liver disease. 1.8%. Hypertension. 2.1% ... Kidney disease. 3.7%. Chronic lower respiratory diseases. 3.0%. Unintentional injuries. 3.7%. 7. Chronic lower respiratory ...
Kidney disease. 1.8%. 10. Benign neoplasms. 1.0%. Septicemia. 1.2%. Kidney disease. 1.6%. Septicemia. 1.8%. Kidney disease. 1.7 ... Benign neoplasms. In situ neoplasms, benign neoplasms and neoplasms of uncertain or unknown behavior. ... Kidney disease. 2.1%. Hypertension. 1.9%. Influenza and pneumonia. 2.1%. 9. Chronic lower respiratory diseases. 1.2%. Pregnancy ... Kidney disease. Nephritis, nephrotic syndrome and nephrosis. Perinatal conditions. Certain conditions originating in the ...
Neoplasms. Resources from HONselect Kidney Cancer Drug Shows Promise in Early Trial 93 percent had tumor growth controlled for ... The U.S. National Cancer Institute has more on kidney cancer.. SOURCE: European Organisation for Research and Treatment of ... Clear cell is the most common form of kidney cancer, accounting for 75 percent of cases, the researchers said. All 12 patients ... This stage 1 clinical trial found that the drug was effective in most patients with advanced kidney cancer when used in ...
Kidney & urinary tract neoplasms. *Comparative Statistics: National Averages *Definitions. Hospital Statistics. Comparative ...
  • It could be kidney cancer (renal cell carcinoma). (healthtap.com)
  • Renal cell carcinoma in children with diffuse cystic hyperplasia of the kidneys. (lookfordiagnosis.com)
  • histology showed a small cell malignant tumor and the diagnosis of PNET (primary of kidney ) and small cell carcinoma were suspected. (lookfordiagnosis.com)
  • Hereditary kidney cancer syndromes include von Hippel-Lindau disease, hereditary leiomyomatosis and renal cell cancer, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma. (oncolink.org)
  • To assess whether daily treatment with RAD001 could slow the growth and spread of metastatic carcinoma of the kidney. (clinicaltrials.gov)
  • What Is Kidney Cancer (Renal Cell Carcinoma)? (medlineplus.gov)
  • Clear cell renal cell carcinoma (ccRCC) is the most common adult kidney cancer. (urotoday.com)
  • DRG Group #656-661 - Kidney and ureter procedures for neoplasm with MCC. (icd.codes)
  • what does benign neoplasm kidney mean? (healthtap.com)
  • But a benign neoplasm does not need to come out, unless it grows over time. (healthtap.com)
  • What does benign neoplasm of colon mean? (healthtap.com)
  • What does benign neoplasm of scap and skin of neck means? (healthtap.com)
  • D30.01 is a billable code used to specify a medical diagnosis of benign neoplasm of right kidney. (icdlist.com)
  • The ICD-10-CM code D30.01 might also be used to specify conditions or terms like benign neoplasm of right kidney or benign tumor of renal parenchyma or oncocytoma of kidney or oncocytoma of right kidney. (icdlist.com)
  • Most kidney diseases attack the nephrons. (icdlist.com)
  • Plasma cell neoplasms are diseases in which the body makes too many plasma cells. (oncolink.org)
  • Plasma cell neoplasms are diseases in which abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body. (oncolink.org)
  • Medscape Reference: Cystic Diseases of the Kidney Treatment & Management. (cancer.ca)
  • Of the cystic kidney diseases, the most common is polycystic kidney disease with two sub-types: the less prevalent autosomal recessive and more prevalent autosomal dominant. (wikipedia.org)
  • Pathology of sporadic renal neoplasms. (cancer.ca)
  • Tumors or cancers of the KIDNEY. (nih.gov)
  • A variant of t(14;18)-negative nodal diffuse follicular lymphoma (FL) with 1p36 deletion has been proposed in the 2017 World Health Organization (WHO) classification of lymphoid neoplasms. (medscape.com)
  • In the United States in 2017, about 63,990 cases of kidney cancer and renal pelvis cancer are expected to occur and lead to more than 14,400 deaths. (uni-bonn.de)
  • Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances. (who.int)
  • Approximately 15 percent of kidney neoplasms are in the renal pelvis and appear to be caused by the same carcinogens as bladder cancer, while the remaining 85 percent are in the parenchyma and have an apparently different etiology. (cdc.gov)
  • ICD-10 Code range (C00-D49), Neoplasms, contains ICD-10 codes for Malignant neoplasms, situ neoplasms, Benign neuroendocrine tumors, Neoplasms of unspecified behavior, polycythemia vera and myelodysplastic syndromes. (aapc.com)
  • The Registry of Toxic Effects of Chemical Substances published by NIOSH indicates that 174 substances have been found to cause kidney tumors in animals or humans. (cdc.gov)
  • The relevancy of findings of kidney cancers in experimental animals to humans is questionable. (cdc.gov)
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
  • The ICD-10 code range for ICD-10 Malignant neoplasms of urinary tract C64-C68 is medical classification list by the World Health Organization (WHO). (aapc.com)
  • Malignant neoplasms [Levy BS and Wegman DH 2011]. (cdc.gov)
  • MONDAY, April 9, 2018 (HealthDay News) -- Belly fat reduces a woman's chances for surviving kidney cancer, but not a man's, a new study suggests. (hon.ch)
  • 2018) Vasostatin-1: A novel circulating biomarker for ileal and pancreatic neuroendocrine neoplasms. (plos.org)
  • These recommendations represent an update from the renal component of the JACR 2010 white paper on managing incidental findings in the adrenal glands, kidneys, liver, and pancreas. (urotoday.com)
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • Little is known about the outcomes of gastric endoscopic submucosal dissection (ESD) in patients with chronic kidney disease (CKD). (nih.gov)
  • Chronic kidney disease damages the nephrons slowly over several years. (icdlist.com)
  • The prevalence of chronic kidney disease (CKD) was 11% (6.6% having stage 3 and 4.4% having stage 4). (kjim.org)
  • Recently, it has been reported that patients with Philadelphia-negative MPN had a high incidence (29%) of chronic kidney disease (CKD) at diagnosis, which was assumed to be due primarily to chronic inflammation, related to the elevated cell counts [ 13 ]. (kjim.org)
  • Every year 13.3 million people suffer acute kidney injury (AKI), which is associated with a high risk of death or development of long-term chronic kidney disease (CKD) in a substantial percentage of patients besides other organ dysfunctions. (urotoday.com)
  • Background Whether testing for chronic kidney disease (CKD) may enhance the care of persons at risky for complications remains uncertain. (exposed-skin-care.net)
  • See related handout on chronic kidney disease , written by the authors of this article. (aafp.org)
  • Chronic kidney disease affects approximately 19 million adult Americans, and its incidence is increasing rapidly. (aafp.org)
  • Diabetes and hypertension are the underlying causes in most cases of chronic kidney disease. (aafp.org)
  • Unfortunately, chronic kidney disease often is overlooked in its earliest, most treatable stages. (aafp.org)
  • Guidelines from the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) recommend estimating glomerular filtration rate and screening for albuminuria in patients with risk factors for chronic kidney disease, including diabetes, hypertension, systemic illnesses, age greater than 60 years, and family history of chronic kidney disease. (aafp.org)
  • When chronic kidney disease is detected, an attempt should be made to identify and treat the specific underlying condition(s). (aafp.org)
  • The KDOQI guidelines define major treatment goals for all patients with chronic kidney disease. (aafp.org)
  • Primary care physicians have an important role in detecting chronic kidney disease early, in instituting measures to slow disease progression, and in providing timely referral to a nephrologist. (aafp.org)
  • All adults with risk factors for chronic kidney disease should be screened with a serum creatinine determination for GFR estimation and analysis of a random urine sample for proteinuria. (aafp.org)
  • Interventions proved to slow the progression of chronic kidney disease include blood pressure control, glycemic control, and reduction of proteinuria with an angiotensin-converting enzyme inhibitor or angiotensin-II receptor blocker. (aafp.org)
  • A low-density lipoprotein goal of less than 100 mg per dL (2.60 mmol per L) is recommended for patients with chronic kidney disease, because these patients are statistically at highest risk for cardiovascular disease. (aafp.org)
  • neoplasm of lymphoid tissue, what is the medical term? (healthtap.com)
  • Multiple myeloma, plasmacytoma, lymphoplasmacytic lymphoma, and monoclonal gammopathy of undetermined significance (MGUS) are different types of plasma cell neoplasms. (oncolink.org)
  • This PDQ cancer information summary has current information about treatment of plasma cell neoplasms (including multiple myeloma). (oncolink.org)
  • Plasma cell neoplasms can be benign (not cancer) or malignant (cancer). (oncolink.org)
  • There are several types of plasma cell neoplasms. (oncolink.org)
  • Multiple myeloma and other plasma cell neoplasms may cause a condition called amyloidosis. (oncolink.org)
  • Age can affect the risk of plasma cell neoplasms. (oncolink.org)
  • Tests that examine the blood, bone marrow, and urine are used to detect (find) and diagnose multiple myeloma and other plasma cell neoplasms. (oncolink.org)
  • You have a higher risk of kidney disease if you have diabetes, high blood pressure, or a close family member with kidney disease. (icdlist.com)
  • Your doctor can do blood and urine tests to check if you have kidney disease. (icdlist.com)
  • All 12 patients with this type of kidney cancer had their disease controlled. (hon.ch)
  • Acquired cystic kidney disease: the hormonal hypothesis. (biomedsearch.com)
  • Occupational kidney cancer is a relatively recently identified disease and the occurrence and etiology is poorly understood at present. (cdc.gov)
  • Conclusions: These experiments demonstrated that endoglin was underexpressed in RCC compared to normal kidney and the presence of enhanced expression is associated with metastatic disease. (usp.br)
  • Cystic kidney disease refers to a wide range of hereditary, developmental, and acquired conditions and with the inclusion of neoplasms with cystic changes, over 40 classifications and subtypes have been identified. (wikipedia.org)
  • Cystic disease may involve one or both kidneys and may, or may not, occur in the presence of other anomalies. (wikipedia.org)
  • Autosomal recessive polycystic kidney disease (ARPKD) is primarily diagnosed in infants and young children while autosomal dominant polycystic kidney disease (ADPKD) is most often diagnosed in adulthood. (wikipedia.org)
  • Another example of cystic kidney disease is Medullary sponge kidney. (wikipedia.org)
  • Cystic kidney disease includes various conditions related to the formation of cysts in one or both kidneys. (wikipedia.org)
  • The most common subset is polycystic kidney disease (PKD) which is a genetic anomaly with two subsets, autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD). (wikipedia.org)
  • Examples of acquired cystic kidney disease include simple cysts and medullary sponge kidney (MSK). (wikipedia.org)
  • Other types of genetic cystic kidney disease include juvenile nephronophthisis (JNPHP), medullary cystic kidney disease (MCKD), and glomerulocystic kidney disease (GCKD). (wikipedia.org)
  • Mutations in genes PKD1 and PKD2 are responsible for autosomal dominant polycystic kidney disease (ADPKD). (wikipedia.org)
  • Those genes encode for polycystic proteins and mutations regarding those genes are inherited and responsible for the disorder of autosomal dominant cystic kidney disease. (wikipedia.org)
  • The disease is usually manifested before age 30, and 45% develop kidney failure by age 60. (wikipedia.org)
  • Mutation in the HDK1 gene is currently thought to be responsible for autosomal recessive polycystic kidney disease (ARPKD), often diagnosed shortly after birth and usually before 15 years of age. (wikipedia.org)
  • citation needed] Many forms of cystic kidney disease can be detected in children prior to birth. (wikipedia.org)
  • BCR-ABL1 -negative myeloproliferative neoplasm (MPN) is an operational subcategory of MPN that includes polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and prefibrotic PMF, according to the World Health Organization (WHO) classification system for hematopoietic tumors [ 1 ]. (kjim.org)
  • Large Multicystic Dysplastic Kidney Mimicking a Large Cystic Renal Neoplasm. (jcdr.net)
  • Primary carcinoid tumor of the kidney is uncommon. (urotoday.com)
  • Specifically, ChIP-seq disclosed enrichment of histone crotonylation at the genes encoding the mitochondrial biogenesis regulator PGC-1α and the sirtuin-3 decrotonylase in both TWEAK-stimulated tubular cells and in AKI kidney tissue. (biologists.org)
  • OBJECTIVES: This study analyzed the expression of these four genes in normal kidney tissue and RCC and relationship with prognostic factors. (usp.br)
  • ESD for gastric epithelial neoplasms can be performed in stage 3 CKD patients with comparable efficacy and safety to that performed in non-CKD patients. (nih.gov)
  • WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- An experimental drug may show promise in treating kidney cancer, researchers say. (hon.ch)
  • The percentage of kidney cancers attributed to occupational factors has not been reported, since there is too little data for useful estimates. (cdc.gov)
  • This stage 1 clinical trial found that the drug was effective in most patients with advanced kidney cancer when used in combination with another cancer drug called everolimus (Afinitor, Zortress). (hon.ch)
  • This phase I/II trial is studying the side effects and best dose of isotretinoin when given together with vorinostat and to see how well they work in treating patients with advanced kidney cancer. (clinicaltrials.gov)
  • Eligible patients must be at least 18 years of age with a diagnosis of metastatic kidney cancer. (pfizer.com)
  • It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI). (centerwatch.com)
  • From January 2005 to December 2014, 102 CKD patients underwent ESD for gastric neoplasms at a tertiary medical institution were reviewed retrospectively. (nih.gov)
  • Meric-Bernstam said it has significant potential in combination therapy for kidney cancer patients. (hon.ch)
  • Phase I trial to study the effectiveness of erlotinib in treating patients who have metastatic or unresectable solid tumors and liver or kidney dysfunction. (clinicaltrials.gov)
  • However, because this drug can damage the kidneys, it is necessary to determine what doses of the drug can safely be given to patients with poor kidney function. (clinicaltrials.gov)
  • Patients with advanced cancer, poorly functioning kidneys, and no good standard treatment options are eligible for this study. (clinicaltrials.gov)
  • Chromogranin A (CgA) is a plasma biomarker widely used in the follow-up of patients with neuroendocrine neoplasms (NENs). (plos.org)
  • In the present study, we studied the prevalence of CKD and progression patterns of kidney function in patients with BCR-ABL1 -negative MPN in a Korean population. (kjim.org)
  • To assess normal tissue toxicity, patients' simulation films and/or treatment records were reviewed for all 77 patients treated with local EBB and estimates were made of the percentage lung, heart and kidney in the radiation field. (osti.gov)
  • 9 of these patients had direct kidney irradiation, defined as 10% or greater of total kidney volume. (osti.gov)
  • None of the 9 patients who received direct kidney irradiation have developed signs of kidney injury, although 1 of the 21 patients who received abdominal radiation developed a hemolytic uremia syndrome. (osti.gov)
  • In some patients, MGUS may later become a more serious condition , such as amyloidosis , or cause problems with the kidneys, heart, or nerves . (oncolink.org)
  • With neoplasm-associated pericarditis, initial treatment includes relief of tamponade, confirmation of the diagnosis, and systemic treatment of the neoplasm. (medscape.com)
  • Systemic crotonate administration protected from experimental AKI, preventing the decrease in renal function and in kidney PGC-1α and sirtuin-3 levels as well as the increase in CCL2 expression. (biologists.org)
  • Ratios (R) of u(iodine-label)/u(indium-label) were determined for liver, spleen, kidneys, lung and tumor. (osti.gov)
  • Abnormalities which affect both kidneys can have an effect on the baby's amniotic fluid volume which can in turn lead to problems with lung development. (wikipedia.org)
  • Candidates will be screened with imaging tests, such as CT and MRI scans, to determine the size and location of the cancer and with blood and urine tests to evaluate kidney and liver function. (clinicaltrials.gov)
  • Tests to diagnose kidney cancer include blood, urine, and imaging tests. (medlineplus.gov)
  • Learn about the genetics, clinical manifestations, and management of these hereditary kidney cancer syndromes in this expert-reviewed summary. (oncolink.org)
  • The aim of this study is to prove the hypothesis that desflurane is safer than sevoflurane in terms of the association with postoperative acute kidney injury (AKI) after liver resection surgery. (centerwatch.com)
  • Acute kidney injury (AKI) is a potentially lethal condition for which no therapy is available beyond replacement of renal function. (biologists.org)
  • The primary goal of the study is to evaluate the effectiveness and safety of SU-011,248 as a treatment for metastatic kidney cancer. (pfizer.com)
  • 3 Sarcomatous tumours of the kidney. (indigo.ca)
  • Cancer of the kidney was reviewed. (cdc.gov)
  • ICD-9 code V10.52 for Personal history of malignant neoplasm of kidney is a medical classification as listed by WHO under the range -PERSONS WITH POTENTIAL HEALTH HAZARDS RELATED TO PERSONAL AND FAMILY HISTORY (V10-V19). (aapc.com)
  • what does skin neoplasm of uncertain behavior mean? (healthtap.com)
  • These antibody proteins build up in the bone marrow and can cause the blood to thicken or can damage the kidneys . (oncolink.org)
  • There was no family history of neoplasms, gastrointestinal problems, seizure, congenital heart problems, hemoglobinemias or other major illnesses. (ispub.com)
  • Renal cell cancer (RCC), which is distinct from kidney cancer that involves the renal pelvis or renal medulla, occurs in both sporadic and heritable forms. (oncolink.org)
  • 2 ] RCC is distinct from kidney cancer that involves the renal pelvis or renal medulla, and it only applies to cancer that forms in the lining of the kidney bed (i.e., in the renal tubules). (uni-bonn.de)
  • Non-RCCs of the kidney, including cancer of the renal pelvis or renal medulla, are not addressed in this summary. (uni-bonn.de)
  • C79.02 is a billable ICD code used to specify a diagnosis of secondary malignant neoplasm of left kidney and renal pelvis. (icd.codes)

No images available that match "kidney neoplasms"