A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.
A group of FLAVONOLS based on kaempferol. They are derived from naringenin and can be hydroxylated to QUERCETIN or reduced to leucopelargonidin.
A plant genus of the family TROPAEOLACEAE. The common nasturtium is a plant that grows 2.4-3.6 m (8-12 feet) tall and has funnel-shaped flowers that are commonly yellow-orange with red spots or stripes and have a long spur that contains sweet nectar. Some species in this genus are called watercress which is also a common name for RORIPPA and NASTURTIUM.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
A plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. They are parasites that form connections (haustoria) to their hosts to obtain water and nutrients. The one-seeded fruit may be surrounded by a brightly colored nut-like structure.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A group of phenyl benzopyrans named for having structures like FLAVONES.
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.
A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The period of history before 500 of the common era.
Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.
A publication issued at stated, more or less regular, intervals.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
A plant family of the order Fagales subclass Hamamelidae, class Magnoliopsida.
An order of BIRDS comprising the waterfowl, particularly DUCKS; GEESE; swans; and screamers.
The reproductive organs of plants.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
A plant genus of the family BETULACEAE known for the edible nuts.
A plant genus of the family TILIACEAE. Members contain cycloartane saponins and CARDENOLIDES.
Tumors or cancer located in bone tissue or specific BONES.

Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. (1/182)

The protective effect of flavonoids against linoleic acid hydroperoxide (LOOH)-induced cytotoxicity was examined by using cultured endothelial cells. When the cells were incubated with both LOOH and flavonoids, most flavonols protected the cells from injury by LOOH. Flavones bearing an ortho-dihydroxy structure also showed a protective effect against the cytotoxicity of LOOH. However, flavanones had no effect. The structure-activity relationship revealed the presence of either the ortho-di-hydroxy structure in the B ring of the flavonoids or 3-hydroxyl and 4-oxo groups in the C ring to be important for the protective activities. The interaction between flavonoids and a-tocopherol was also examined in this system. Flavonoids that were protective against LOOH-induced cytotoxicity had at least an additive effect on the action of alpha-tocopherol against LOOH-induced damage.  (+info)

Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. (2/182)

Transcriptional activation of the human CYP1A1 gene (coding for cytochrome P450 1A1) is mediated by the aryl hydrocarbon receptor (AhR). In the present study we have examined the effect of the common dietary polyphenolic compounds quercetin and kaempferol on the transcription of CYP1A1 and the function of the AhR in MCF-7 human breast cancer cells. Quercetin caused a time- and concentration-dependent increase in the amount of CYP1A1 mRNA and CYP1A1 enzyme activity in MCF-7 cells. The increase in CYP1A1 mRNA caused by quercetin was prevented by the transcription inhibitor actinomycin D. Quercetin also caused an increase in the transcription of a chloramphenicol reporter vector containing the CYP1A1 promoter. Quercetin failed to induce CYP1A1 enzyme activity in AhR-deficient MCF-7 cells. Gel retardation studies demonstrated that quercetin activated the ability of the AhR to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the CYP1A1 promoter. These results indicate that quercetin's effect is mediated by the AhR. Kaempferol did not affect CYP1A1 expression by itself but it inhibited the transcription of CYP1A1 induced by the prototypical AhR ligand 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), as measured by a decrease in TCDD-induced CYP1A1 promoter-driven reporter vector activity, and CYP1A1 mRNA in cells. Kaempferol also abolished TCDD-induced XRE binding in a gel-shift assay. Both compounds were able to compete with TCDD for binding to a cytosolic extract of MCF-7 cells. Known ligands of the AhR are, for the most part, man-made compounds such as halogenated and polycyclic aromatic hydrocarbons. These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription.  (+info)

The small intestine can both absorb and glucuronidate luminal flavonoids. (3/182)

We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum.  (+info)

In vitro glucuronidation of kaempferol and quercetin by human UGT-1A9 microsomes. (4/182)

Flavonoids are important polyphenolic substances with widespread occurrence in plants and therefore in the human diet. Although considerable work has been done on the pharmacology of flavonoids, the understanding of their metabolism is still incomplete. In this work, the in vitro glucuronidation of the common dietary flavonoids quercetin and kaempferol by human UDP-glucuronosyltransferase microsomes (UGT-1A9) was investigated using HPLC and LC-MS. The two flavonoids were extensively metabolised by this enzyme with four monoglucuronides of quercetin and two of kaempferol being detected after incubation. The presence of a quercetin monoglucuronide in the urine of a volunteer after consumption of Ginkgo biloba tablets was demonstrated.  (+info)

Isolation and characterization of cDNAs expressed in the early stages of flavonol-induced pollen germination in petunia. (5/182)

Petunia (Petunia hybrida) pollen requires flavonols (Fl) to germinate. Adding kaempferol to Fl-deficient pollen causes rapid and synchronous germination and tube outgrowth. We exploited this system to identify genes responsive to Fls and to examine the changes in gene expression that occur during the first 0.5 h of pollen germination. We used a subtracted library and differential screening to identify 22 petunia germinating pollen clones. All but two were expressed exclusively in pollen and half of the clones were rare or low abundance cDNAs. RNA gel-blot analysis showed that the steady-state transcript levels of all the clones were increased in response to kaempferol. The sequences showing the greatest response to kaempferol encode proteins that have regulatory or signaling functions and include S/D4, a leucine-rich repeat protein, S/D1, a LIM-domain protein, and D14, a putative Zn finger protein with a heme-binding site. Eight of the clones were novel including S/D10, a cDNA only expressed very late in pollen development and highly up-regulated during the first 0.5 h of germination. The translation product of the S/D3 cDNA shares some features with a neuropeptide that regulates guidance and growth in the tips of extending axons. This study confirmed that the bulk of pollen mRNA accumulates well before germination, but that specific sequences are transcribed during the earliest moments of Fl-induced pollen germination.  (+info)

The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. (6/182)

Amyloid beta protein (Abeta) elicits a toxic effect on neurons in vitro and in vivo. In present study we attempt to elucidate the mechanism by which Abeta confers its neurotoxicity. The neuroprotective effects of phytoestrogens on Abeta-mediated toxicity were also investigated. Cortical neurons treated with 5 microm Abeta-(25-35) for 40 h decreased the cell viability by 45.5 +/- 4.6% concomitant with the appearance of apoptotic morphology. 50 microm kaempferol and apigenin decreased the Abeta-induced cell death by 81.5 +/- 9.4% and 49.2 +/- 9.9%, respectively. Abeta increased the activity of caspase 3 by 10.6-fold and to a lesser extent for caspase 2, 8, and 9. The Abeta-induced activation of caspase 3 and release of cytochrome c showed a biphasic pattern. Apigenin abrogated Abeta-induced cytochrome c release, and the activation of caspase cascade. Kaempferol showed a similar effect but to a less extent. Kaempferol was also capable of eliminating Abeta-induced accumulation of reactive oxygen species. These two events accounted for the remarkable effect of kaempferol on neuroprotection. Quercetin and probucol did not affect the Abeta-mediated neurotoxicity. However, they potentiated the protective effect of apigenin. Therefore, these results demonstrate that Abeta elicited activation of caspase cascades and reactive oxygen species accumulation, thereby causing neuronal death. The blockade of caspase activation conferred the major neuroprotective effect of phytoestrogens. The antioxidative activity of phytoestrogens also modulated their neuroprotective effects on Abeta-mediated toxicity.  (+info)

Accumulation of soluble and wall-bound indolic metabolites in Arabidopsis thaliana leaves infected with virulent or avirulent Pseudomonas syringae pathovar tomato strains. (7/182)

The chemical structures and accumulation kinetics of several major soluble as well as wall-bound, alkali-hydrolyzable compounds induced upon infection of Arabidopsis thaliana leaves with Pseudomonas syringae pathovar tomato were established. All identified accumulating products were structurally related to tryptophan. Most prominent among the soluble substances were tryptophan, beta-d-glucopyranosyl indole-3-carboxylic acid, 6-hydroxyindole-3-carboxylic acid 6-O-beta-d-glucopyranoside, and the indolic phytoalexin camalexin. The single major accumulating wall component detectable under these conditions was indole-3-carboxylic acid. All of these compounds increased more rapidly, and camalexin as well as indole-3-carboxylic acid reached much higher levels, in the incompatible than in the compatible P. syringae/A. thaliana interaction. The only three prominent phenylpropanoid derivatives present in the soluble extract behaved differently. Two kaempferol glycosides remained largely unaffected, and sinapoyl malate decreased strongly upon bacterial infection with a time course inversely correlated with that of the accumulating tryptophan-related products. The accumulation patterns of both soluble and wall-bound compounds, as well as the disease resistance phenotypes, were essentially the same for infected wild-type and tt4 (no kaempferol glycosides) or fah1 (no sinapoyl malate) mutant plants. Largely different product combinations accumulated in wounded or senescing A. thaliana leaves. It seems unlikely that any one of the infection-induced compounds identified so far has a decisive role in the resistance response to P. syringae.  (+info)

Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. (8/182)

The 190-kDa phosphoglycoprotein multidrug resistance protein 1 (MRP1) (ABCC1) confers resistance to a broad spectrum of anticancer drugs and also actively transports certain xenobiotics with reduced glutathione (GSH) (cotransport) as well as conjugated organic anions such as leukotriene C(4) (LTC(4)). In the present study, we have investigated a series of bioflavonoids for their ability to influence different aspects of MRP1 function. Most flavonoids inhibited MRP1-mediated LTC(4) transport in membrane vesicles and inhibition by several flavonoids was enhanced by GSH. Five of the flavonoids were competitive inhibitors of LTC(4) transport (K(i), 2.4-21 microM) in the following rank order of potency: kaempferol > apigenin (+ GSH) > quercetin > myricetin > naringenin (+ GSH). These flavonoids were less effective inhibitors of 17beta-estradiol 17beta-(D-glucuronide) transport. Moreover, their rank order of inhibitory potency for this substrate differed from that for LTC(4) transport inhibition but correlated with their relative lipophilicity. Several flavonoids, especially naringenin and apigenin, markedly stimulated GSH transport by MRP1, suggesting they may be cotransported with this tripeptide. Quercetin inhibited the ATPase activity of purified reconstituted MRP1 but stimulated vanadate-induced trapping of 8-azido-alpha-[(32)P]ADP by MRP1. In contrast, kaempferol and naringenin stimulated both MRP1 ATPase activity and trapping of ADP. In intact MRP1-overexpressing cells, quercetin reduced vincristine resistance from 8.9- to 2.2-fold, whereas kaempferol and naringenin had no effect. We conclude that dietary flavonoids may modulate the organic anion and GSH transport, ATPase, and/or drug resistance-conferring properties of MRP1. However, the activity profile of the flavonoids tested differed from one another, suggesting that at least some of these compounds may interact with different sites on the MRP1 molecule.  (+info)

Title: A Review on the Dietary Flavonoid Kaempferol. VOLUME: 11 ISSUE: 4. Author(s):J. M. Calderon-Montano, E. Burgos-Moron, C. Perez-Guerrero and M. Lopez-Lazaro. Affiliation:Department of Pharmacology, Faculty of Pharmacy. University of Seville, C/ Profesor García Gonzalez, n° 2, 41012, Sevilla, Spain.. Keywords:Flavonoids, antioxidant, anti-inflammatory, cancer, kaempherol, astragalin, tiliroside, kaempferitrin, robinin, Dietary, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, edible plants, cardiovascular diseases, glycosides. Abstract: Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) ...
Sigma-Aldrich offers abstracts and full-text articles by [Xi-Lan Tang, Jian-Xun Liu, Wei Dong, Peng Li, Lei Li, Jin-Cai Hou, Yong-Qiu Zheng, Cheng-Ren Lin, Jun-Guo Ren].
TY - JOUR. T1 - Hydrophilic astragalin galactoside induces T helper type 1-mediated immune responses via dendritic cells. AU - Jeon, Jae Hyoung. AU - Lee, Byung Cheol. AU - Kim, Doman. AU - Cho, Dae Ho. AU - Kim, Tae Sung. PY - 2018/10/11. Y1 - 2018/10/11. N2 - A flavonoid Astragalin (kaempferol-3-O-β-D-glucopyranoside, Ast) has several biological activities including anti-oxidant, anti-HIV, and anti-allergic effects. Nonetheless, its insolubility in hydrophilic solvents imposes restrictions on its therapeutic applications. In this study, we investigated the effects of water-soluble astragalin-galactoside (kaempferol-3-O-β-D-isomaltotrioside, Ast-Gal) on murine bone marrow-derived dendritic cell (DC) maturation and T helper (Th) cell-mediated immune responses. Ast-Gal significantly increased maturation and activation of DCs through the upregulation of surface markers, such as cluster of differentiation (CD)80, CD86, and Major histocompatibility complex (MHC) II in a dose-dependent manner, ...
A vast variety of naturally occurring substances have been shown to protect against experimental carcinogenesis and an increasing amount of evidence suggests that kaempferol may have cancer chemopreventative properties. However, the precise underlying protective mechanisms are poorly understood. To …
The Global Quercetin-3-Rhamnoside industry 2020 assists the specialists to make choices dependent on the market investigation. The report presents segmentation of the global Quercetin-3-Rhamnoside market by end-users, regional countries, product types and key manufacturers based on differentiable validation and industrial analysis. The researchers have offered projections about the global Quercetin-3-Rhamnoside industry size based on value and volume in this part of the report. According to the Quercetin-3-Rhamnoside market report, the industry will garner modest returns by the end of the forecast duration, while expanding at a substantial growth rate. The generated Quercetin-3-Rhamnoside industry report is resolutely pedestal on primary research, interviews with top administrative, news sources and information insiders. Secondary research methods are implemented for better appreciative and clarity for data analysis ...
The Global Quercetin-3-Rhamnoside Market Market report offers the present status and the improved specialties of the Global Quercetin-3-Rhamnoside Market Market for the period 2020-2027. The report has been scattered with the subject to huge Market analysis with data from industry experts. The Quercetin-3-Rhamnoside Market research report consolidates a broad examination of the Quercetin-3-Rhamnoside Market Market, assembling by different fields, areas, and commanding players. Estimation of different Quercetin-3-Rhamnoside Market Market use and the concerning structure got by the market is besides assessed in the report. Particular parameters essential in incorporate structure in the industry, for instance, client solicitation and supply figures, cost of age, net earnings, and offering an estimation of replicas and affiliations are in like manner included inside the extent of the research report.. Get Free Sample of Research Report 2020 @ ...
In a recent program to investigate the possible use of vegetable handling and commercialization wastes and residues as a source of potentially bioactive extracts, we have studied cauliflower byproducts. A total of twenty-eight compounds were characterized by HPLC-DAD-MS, of these, twenty-two are produced naturally by the plant. The main compounds found were kaempferol 3-diglucoside-7-glucoside and its combinations with different hydroxycinnamic acids. Moreover, some flavonoids with an unusual high grade of glycosylation have been isolated and tentatively identified for the first time. To our knowledge, the characterization of flavonoids with more than four sugars has not been previously reported. The new products isolated were tentatively identified as kaempferol 3-diglucoside-7-diglucoside, kaempferol 3-triglucoside-7-diglucoside, kaempferol 3-feruloyldiglucoside-7-diglucoside, kaempferol 3-sinapoyltriglucoside-7-glucoside, kaempferol 3-disinapoyltriglucoside-7-glucoside, kaempferol ...
Keywords: Kaempferol-7-O-glucoside OR 16290-07-6 OR Populnin OR RZF1QN1Z8R OR kaempferol 7-O-glucoside OR Kaempferol-7-O-beta-D-glucoside OR Kaempferol 7-beta-D-glucopyranoside OR kaempferol 7-O-beta-D-glucopyranoside OR Kaempferol 7-O-beta -D-glucopyranoside ...
Supplementary Materialstjp0590-1389-SD1. elicited propagated reactions that got the purchase Kaempferol features of CICR. The threshold Ca2+? for triggering a reply was 0.5 m or less. As this worth is much less than concentrations prevailing near channels during normal activity, the result supports participation of CICR in the physiological control of contraction in amphibian muscle. As SLICs were applied outside cells, the primary stimulus was Ca2+, rather than the radiation or subproducts of photorelease. Therefore the responses qualify as classic CICR. By contrast, mouse muscle fibres did not respond unless channel-opening drugs were present at purchase Kaempferol substantial concentrations, an observation contrary to the physiological involvement of CICR in mammalian excitationCcontraction coupling. In mouse muscle, the propagating wave had a substantially lower release flux, which together with a much higher threshold justified the absence of response when drugs were not present. The ...
Find quality suppliers and manufacturers of Kaempferol 3-neohesperidosidefor price inquiry.where to buy Kaempferol 3-neohesperidoside.Also offer free database of Kaempferol 3-neohesperidoside including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Kaempferol offers been reported to reduce the risk of ovarian malignancy, but the mechanism is not completely understood. cells, and better characterized kaempferol toward chemoprevention. angiogenesis caused by ovarian malignancy cells, and the pathways involve regulation on HIF1- and ERR- gene expressions (Luo et al., 2009). Anti-angiogenesis is probably the most feasible strategy for current chemoprevention of ovarian cancers, given the fact that these early-stage tiny tumors cannot be successfully diagnosed but their continued development desperately depends on the establishment of a new blood vessel network (Bertl et al., 2006; Carmeliet et al., 2000). Tumor-free adults, on the other hand, have virtually zero need for angiogenesis in normal situations (Fotsis et al., 1993; Glade-Bender et al., 2003). Thus our findings about kaempferols anti-angiogenesis effects (Luo et al., 2009) become more relevant in this context. Nevertheless, the previously investigated pathways for kaempferol are not ...
Global and Chinese Quercetin-3-Rhamnoside Market Competitive Analysis, Trends and Forecast till 2022, with free sample report copy
These findings suggested that kaempferol might be regarded as a bioactive food ingredient to prevent oxidative damage and treat bladder cancer.
Kaempferol reduces inflammatory response. Values are presented as means with their standard deviations (, n = 8); ∗∗P | 0.01, compared with the control g
Our latest product is Flavon Green, which offers the benefits of different vegetables in a complex form. The included vegetables help us maintain a well-balanced diet rich in vitamins, minerals and antioxidants. We all know that regular vegetable consumption has a beneficial effect on our general state of wellbeing - supplying it with special and…
The Flavon max Plus+ is the premium member of our product line. It is an exclusive product created for adults who are at risk because they are subjected to serious strain, and for whom health protection is of high priority because of their lifestyle. Antioxidants and high quality nutrition are very important for the body.…
This MassBank Record with Accession BS003478 contains the MS2 mass spectrum of Kaempferol-3-O-glucoside with the compound class Natural Product. The mass spectrum was acquired on a LC-ESI-QTOF with NEGATIVE ionisation with the collision energy 30 eV at a resolution of null and has the SPLASH splash10-001i-0090100000-7bd32a5c1969c5a248ac.
An additional way to validate compounds is to select frequently occurring ions (likely fragments of several different precursor molecules) and extract them from the MS and also the all-ion fragmentation spectra. A very straight forward example can be illustrated for the previously mentioned quercetin- or kaempferol-containing flavonoids. Based on the fact that quercetin- and kaempferol-based flavonoids are decorated with different numbers and kinds of sugars, it is possible to extract the exact m/z 287.05501 for the kaempferol- and the m/z of 303.04993 for the quercetin-containg peaks from the all-ion fragmentation spectra. This directly leads to the distribution of these flavonoids within the chromatogram. If now the retention time information and the isotope-labelling-derived proper mass-shift data are combined, the separated favonoids can be unambiguous annotated.. ...
1 Four O-acylated flavonol glycosides, new in the plant kingdom, were isolated from the needles of Pseudotsuga menziesii. Their structures were established by 1D and 2D NMR and MS data as: daglesioside I [kaempferol 3-O-[2,5-O-(4,4IV-dihydroxy)-β- truxinoyl]-α-L-arabinofuranoside] (), daglesioside II [kaempferol 3-O-[2,5-O-(4- hydroxy)-β-truxinoyl]-α-L-arabinofuranoside] ( 2 ), daglesioside III [kaempferol 3-O-[2,5- di-O-(E)-p-coumaroyl]-α-L-arabinofuranoside] ( 3 ), and daglesioside IV [kaempferol 3-O-[3,6-di-O-(E)-cinnamoyl]-β-D-glucopyranoside] ( 4 ). In addition, the known fl avonoids (E)-tiliroside, (E)-ditiliroside, astragalin (kaempferol 3-O-β-D-glucopyranoside), isorhamnetin, kaempferol, and quercetin were identifi ed. The cytotoxic activity of... compounds 1 and 3 was evaluated towards the HL-60, HeLa, and MDA-MB468 cell lines. ...
Kaempferol is a natural flavonoid. Previous studies have reported that kaempferol has anti-proliferation activities and induces apoptosis in many cancer cell lines. However, there are no reports on human osteosarcoma. In this study, we investigate the anti-cancer effects and molecular mechanisms of …
The enzyme acts on the hydroxy group in the 4-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as
kaempferol-3-O-(6,4-di-p-coumaroyl)mannopyranoside: isolated from the flower of Castanea mollissima; structure in first source
Fruit of Cucumis sativus, a widely cultivated plant in the gourd family Cucurbitaceae, which includes squash, and in the same genus as the muskmelon. Usually eaten raw in unripe green form, as a vegetable. Majority of people describe the taste as mild, light melon-like and almost watery while a small minority think its repugnant and perfume-like. Can be used in salads, appetizers, sauces, sandwiches, cocktails, cold soups and stir fry. Has many health benefits (due to high content of minerals) and cosmetic properties (due to its cooling and cleansing effect). one medium cucumber contains 1.25 cup of water, 12% daily value of potassium, 14% of vitamin C, 9% of Magnesium, 0.4g of flavonoid Kaempferol ...
Kaempferol, a compound extracted from Ginkgo biloba, inhibits cell proliferation and induces programmed cell death in pancreatic cancer cells, in vitro.
Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol‑7‑O‑α‑L‑rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence spectroscopy and molecular modeling. KR can quench the intrinsic fluorescence of HSA through the formation of a KR‑HSA complex in a static manner. In addition, the binding site is located in subdomain IIA as confirmed by competitive experiments using site‑specific warfarin and ibuprofen, and the driving forces include hydrogen bonds, van der Waals forces and electrostatic interaction derived from a thermodynamic analysis. The formation of KR‑HSA is exothermic and spontaneous. Although there is no hydrophobic interaction around Tyr and Trp residues, the secondary structure of HSA changes through the formation of the KR‑HSA complex. In addition, docking results ...
Apigenin could be used to potentially increase the effects of cisplatin by targeting cancer stem cells subset in prostate cancer.
PlantBioFit 4 oz. Liquid Flavonoid Foliar Concentrate. A natural crop synergist. 4 oz. bottle makes up to 40 gallons of foliar spray.
Flavonoids are found in virtually thousands of different plants and substances. The main purpose of the flavonoids is to protect the body. They do this by acting as antioxidants who protect the healthy cells of the body from the harm that free-radicals cause. Flavonoids have the ability of making the levels of glutathione higher. Glutathione is a very robust antioxidant that protects the cells from being compromised.. Flavonoids are related with Vitamin C and are an invaluable support to the many benefits of Vitamin C. They are like little power-boosters. When the two, Vitamin C and Flavonoids are operating together, the antioxidant qualities and benefits are super-charged.. ...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Flavonoids are a diverse range of polyphenolic compounds that are present in plant-based foods such as fruits, vegetables, coffee, tea, chocolate and wine. In this study, dietary flavonoids were divided into six subclasses, and their effects on the body composition of women were investigated. Read more ...
British researchers believe that certain plant substances can influence the amount of body fat. There is this simple rule: If you consume fewer calories than
In the first research of its kind, dietary flavonols have been linked to a significantly lower risk for Alzheimers. However, some experts are calling for healthy skepticism when interpreting the findings.
Vellosa, Jos Carlos Rebuglio et al. Antioxidant and cytotoxic studies for kaempferol, quercetin and isoquercitrin. Eclet. Qu m., 2011, vol.36, no.2, p.07-20. ISSN 0100- ...
Supplementary MaterialsExpanded Look at Figures PDF emmm0007-1465-sd1. metabolic and hereditary requirements required to be able to create a healthful pregnancy. The recognition from the embryo with the best developmental capability represents a significant problem for fertility treatment centers. Current options for the evaluation of embryo competence are tested inefficient, as well as the inadvertent transfer of nonviable embryos may be the principal reason most IVF remedies (around two-thirds) result in failure. In this scholarly study, we investigate the way the Kaempferol tyrosianse inhibitor software of proteomic measurements could improve achievement rates in medical embryology. We explain an operation which allows the quantification and recognition of proteins of embryonic source, within attomole concentrations in the blastocoel, the enclosed fluid-filled cavity that forms within 5-day-old human being embryos. Through the use of targeted proteomics, we demonstrate the feasibility of ...
Flavonoids are all over the news at the moment, boasting how you can slim down by only eating a few grapes and how
When it comes to CBD Oil, professionals recommend using Full spectrum CBD Oils over CBD Isolate, and part of the reason is that they contain what are known as flavonoids and terpenes. In addition to the CBD cannabinoid, the flavonoids and terpenes have their health benefits. What are flavonoids and Terpenes? Flavonoid
Our primary objective will be to offer you our shoppers a serious and responsible enterprise relationship, supplying personalized attention to all of them for Flavonoids Meaning , flavonoids meaning , flavonoids definition , If you have any requests pls email Us with your comprehensive demands we are going to supply you with the most wholesale Competitive Price with the Super Quality and the Unbeatable First-class Service ! We can supply you with the most competitive prices and high quality because we have been much more Specialist! So remember to do not hesitate to contact us ...
Essential C & Flavonoids by Pure Encapsulations - 180 Capsules-Essential C & Flavonoids by Pure Encapsulations By Pure EncapsulationsVitamin C enh
Increased serum uric acid is known to be a major risk related to the development of several oxidative stress diseases. The aim of this study was to investigate the effect of parsley, quercetin and kaempferol on serum uric acid levels, liver xanthine oxidoreductase activity and two non-invasive biomarkers of oxidative stress (total antioxidant capacity and malondialdehyde concentration) in normal and oxonate-induced hyperuricemic rats. A total of 60 male Wistar rats were randomly divided into ten equal groups; including 5 normal groups (vehicle, parsley, quercetin, kaempferol and allopurinol) and 5 hyperuricemic groups (vehicle, parsley, quercetin, kaempferol and allopurinol). Parsley (5 g/Kg), quercetin (5 mg/Kg), kaempferol (5 mg/Kg) and allopurinol (5 mg/Kg) were administrated to the corresponding groups by oral gavage once a day for 2 weeks. The results showed that parsley and its flavonol did not cause any significant reduction in the serum uric acid levels in normal rats, but significantly reduced
TY - JOUR. T1 - Three new flavonol glycosides from Fissistigma pallens. AU - Nhiem, Nguyen Xuan. AU - Thinh, Ngo Sy. AU - Thu, Nguyen Thi Bich. AU - Anh, Luu The. AU - Ngoc, Tran Minh. AU - Tai, Bui Huu. AU - Yen, Pham Hai. AU - van Kiem, Phan. AU - van Minh, Chau. AU - Park, Seonju. AU - Kim, Seung Hyun. N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.79 and by National Research Foundation of (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea; NAFOSTED [104.01-2015.44]; NRF [2016R1A2B4006742].. PY - 2019. Y1 - 2019. N2 - Three new flavonol glycosides, fissflavosides A-C (1-3), together with six known flavonol glycosides, kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (4), kaempferol 3-O-α-L-rham-nopyranosyl-(1→6)-β-D-galactopyranoside (5), kaempferol ...
Title:Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation. VOLUME: 18 ISSUE: 7. Author(s):Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*. Affiliation:Department of Dermatology, First Affiliated Hospital of Xian Jiaotong University, Xian 710061, Shaanxi, Department of Burns and Plastic Surgery, Shaanxi Nuclear Industry 215 Hospital, Xian yang 712000 Shaanxi, Department of Dermatology, First Affiliated Hospital of Xian Jiaotong University, Xian 710061, Shaanxi, Department of Dermatology, First Affiliated Hospital of Xian Jiaotong University, Xian 710061, Shaanxi, Department of Dermatology, First Affiliated Hospital of Xian Jiaotong University, Xian 710061, Shaanxi, Department of Dermatology, First Affiliated Hospital of Xian Jiaotong University, Xian 710061, Shaanxi, Department of Dematology, Affiliated Hospital of Yanan University, Yanan 716000 Shaanxi, Department of Dermatology, First Affiliated Hospital of Xian Jiaotong ...
Flavonols are a subclass of flavonoids of the group of plant secondary metabolites. In planta, flavonols play various functions such as antioxidant and natural regulator of auxin polar transport. Many lines of evidence have shown that flavonols also contribute to human health in anti-oxidation, anti-inflammation, and even prevention some types of cancer. Several methods have been utilized to measure flavonols such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and diphenylboric acid-2-aminoethyl ester (DPBA) staining. While HPLC or LC-MS can quantitatively determine the level of flavonols, DPBA staining can provide an in-situ view of flavonols accumulation in the plants. In this protocol, a detailed procedure for staining the flavonols in Arabidopsis root tips is described. Five-day-old Arabidopsis seedlings are soaked in a solution containing DPBA and latterly the flavonols (kaempferol and quercetin) can be observed under a confocal microscope.,
VELLOSA, José Carlos Rebuglio et al. Antioxidant and cytotoxic studies for kaempferol, quercetin and isoquercitrin. Eclet. Quím. [online]. 2011, vol.36, n.2, pp.07-20. ISSN 0100-4670. http://dx.doi.org/10.1590/S0100-46702011000200001.. The aim of the present study was to investigate a cytotoxic oxidative cell stress related and the antioxidant profile of kaempferol, quercetin, and isoquercitrin. The flavonol compounds were able to act as scavengers of superoxide anion (but not hydrogen peroxide), hypochlorous acid, chloramine and nitric oxide. Although flavonoids are widely described as antioxidants and this activity is generally related to beneficial effects on human health, here we show important cytotoxic actions of three well known flavonoids. They were able to promote hemolysis which one was exacerbated on the presence of hypochlorous acid but not by AAPH radical. Therefore, despite they expected scavenger action over free radicals an oxidants, these compounds could be very lesive to ...
TY - JOUR. T1 - The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids. AU - Cassidy, Aedin. AU - Minihane, Anne-Marie. N1 - This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/). PY - 2017/1. Y1 - 2017/1. N2 - At a population level there is growing evidence for the beneficial effects of dietary flavonoids on health. However there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide inter-individual variability in flavonoid absorption and metabolism. Flavonoids are extensively metabolized by phase I and II- (which occurs predominantly in the gastrointestinal tract and liver) and colonic microbial- metabolism. A number of factors, including age, gender and genotype may impact on these metabolic processes. In addition food composition and flavonoid source is likely to affect bioavailability and emerging data suggest a critical role for the microbiome. ...
Meals by\items happen in various levels of handling and creation in the home and on business scales. and elevated shelf lifestyle by 3?weeks; substances were discovered in muscadine grapes. The substances identified in seed products included hydrolyzable tannins, flavan\3\ols and condensed tannins, ellagic acidity derivatives, and quercetin rhamnoside. Your skin included hydrolyzable flavonoids and tannins, including anthocyanin 3,5\diglucosides, quercetin, myricetin, and kaempferol glycosides ( Sandhu & Gu,?2010). Its been discovered that the most frequent phenol substances in grape seed products were appeared to be flavan\3\ols; many of them are gallocatechin catechin and gallate. The skins had been flavonols mainly, that is, myricetin and quercetin. Perseverance of anthocyanins in the berry epidermis by super\high\functionality liquid chromatography uncovered twenty derivatives of malvidin, delphinidin, petunidin, cyanidin, and peonidin (Panteli? et?al.,?2016). Fruits FR167344 free base ...
PMID: Molecules. 2016 Dec 7 ;21(12). Epub 2016 Dec 7. PMID: 27941619 Abstract Title: Black Crowberry (Empetrum nigrum L.) Flavonoids and Their Health Promoting Activity. Abstract: Nowadays, much research attention is focused on underutilized berry crops due to the high antioxidant activity of fruits. Black crowberry (L.) represents an important source of flavonols (quercetin, rutin, myricetin, naringenin, naringin, morin, and kaempferol) and anthocyanins. The fruit components could be utilised as natural colourants or as a part of functional foods and, because of the high antioxidant activity, the berries of black crowberry can be used in the treatment of diseases accompanied with inflammation, or as an effective antibacterial and antifungal remedy. Moreover, the reduction of lipid accumulation and total cholesterol as well as an improvement of postprandial hyperglycaemia have been proven. This review summarizes for the first time the main antioxidants (flavonoids) of black crowberry fruits, ...
Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure (1). The basic structure of a flavonoid is shown in figure 1. Flavonoids may be further divided into subclasses (see table 1). Over the past decade, scientists have become increasingly interested in the potential for various dietary flavonoids to explain some of the health benefits associated with fruit and vegetable-rich diets. These potential health benefits are being used to promote the consumption of flavonoid-rich foods, beverages and dietary supplements. This article reviews the scientific evidence for the hypothesis that dietary flavonoids promote health and prevent disease in humans. For more detailed information on the health effects of isoflavones, a subclass of flavonoids with estrogenic activity, see the separate article on Soy Isoflavones. For more information on the health benefits of foods that are rich in flavonoids, see separate articles on Fruits and Vegetables, Legumes and ...
We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction. HepG2 cells, stably integrated with regulatory regions of human CYP1A1, were treated with resveratrol, apigenin, curcumin, kaempferol, green tea extract (GTE), (−)-epigallocatechin gallate (EGCG), quercetin, and naringenin. Of these flavonoids, resveratrol produced the greatest increase in CYP1A1-mediated luciferase activity (10-fold), whereas GTE, apigenin, curcumin, and kaempferol produced 2- to 3-fold increases in activity. Compared with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), omeprazole, or benzanthracene, where increases in luciferase activity ranged from 12- to 35-fold, these flavonoids exhibited weak agonist activity. The remaining compounds, EGCG, quercetin, and naringenin, produced negligible effects. Cotreatment of cells with TCDD and GTE, naringenin, and apigenin resulted ...
A new trinuclear oxo-centered chromium(III) complex with formula [Cr3O(CH3CO2)6(L)(H2O)2] (L = 5-hydroxyflavone, known as primuletin) was synthetized and characterized by ESI mass spectrometry, thermogravimetry, and 1H-NMR, UV-Vis, and FTIR spectroscopies. In agreement with the experimental results, DFT calculations indicated that the flavonoid ligand is coordinated to one of the three Cr(III) centers in an O,O-bidentate mode through the 5-hydroxy/4-keto groups. In a comparative study involving the uncoordinated primuletin and its corresponding complex, systematic reactions with the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that antiradical activity increases upon complexation.
Recently, it was also found that UV light selectively induces several primary metabolic activities that are directly or indirectly required for flavonoid formation. This implies complex regulation in the different branches of the phenylpropanoid biosynthesis pathway during UV-B stress. Elevated UV-B radiation significantly increased the concentrations of UV-B-absorbing flavonoids, such as quercetin-3-arabinoside, quercetin-3-glucose + glucuronide and kaempferol- 3-rhamnoside, and a few phenolic acids in silver birch leaves. In Arabidopsis thaliana, the transparent testa-4 (tt4) mutant, which has reduced flavonoids and normal levels of sinapate esters, is more sensitive to UV-B than the wild type when grown under high UV-B irradiance. The tt5 and tt6 mutants, which have reduced levels of UV-absorptive leaf flavonoids and the monocyclic sinapic acid ester phenolic compounds, are highly sensitive to the damaging effects of UV-B radiation. These demonstrated that both flavonoids and other phenolic ...
Lovely piece of data: Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem. 2001 Jun;49(6):3106-12. PubMed PMID: 11410016. Total flavonoids: onion leaves (1497.5 mg/kg quercetin, 391.0 mg/kg luteolin, and 832.0 mg/kg kaempferol) Semambu leaves (2041.0 mg/kg) bird chili (1663.0 mg/kg) black tea (1491.0 mg/kg)…
What are Flavonoids ? Flavonoids are one of the largest nutrient families known to scientists and include over 6,000 already-identified family members. Some of the best-known flavonoids include quercetin, kaempferol, catechins, and anthocyanidins. This nutrient group is most famous for its antioxidant and anti-inflammatory health benefits, as well as its contribution of vibrant color to […]. Continue Reading... ...
This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring constituents of plants that have been traditionally used as anti-inflammatory and anti-cancer medicines. In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased cancer mortalities rates.Flavonoids, Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation and the development of GI and steroid-responsive cancers. In addition, the promise and pitfalls associated with using flavonoids as chemopreventive agents are discussed.This book is an invaluable reference for basic and clinical scientists who are interested in exploring the link between nutrition and cancer.
ChemFaces is Reference Standard and high-purity Natural Products Manufacturer of Isorhamnetin 7-O-glucoside(CFN91115) CAS no.:6743-96-0
A newly published study, which followed participants for up to 24 years, included 124,000 men and women and began in 1986. In total, over 124,000 people between the ages of 27-65 participated. All study participants self-reported their diet every four (4) years using a food frequency questionnaire. Their flavonoid intake was calculated by how frequently they consumed flavonoid-containing foods. Participants also reported on their lifestyle habits and weight every two (2) years. They were also asked to report any changes in smoking status, physical activity level, hours spent sitting or watching TV, and hours of sleep.. Over each four-year period, men gained 2.2lbs on average and women gained 2.9lbs. Intake of flavonoids was an average of 224 milligrams per day in men and 247 milligrams per day in women. Every additional 10 milligrams of daily intake was associated with 0.16 to 0.23 lbs. less weight gained over four-year periods. A quarter cup of strawberries or cherries contains about 10 mg of ...
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB. - Mechanism of Action & Protocol.
it is not a question of 10 is right and 9 is wrong , rather it is my considered opinion but I was anxious to convey the idea of plunging the pots of slow growing specimens. I like the bit of humour and as is a forum everybody is entitled to their opinion. Where plenty answers are offered I rarely reply but when a difficult one arises and I think I can help then I put in a comment ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Abstract Tiliroside is a glycosidic flavonoid present in many plants species including Helicteres velutina K. Schum (Malvaceae sensu lato), commonly known in Brazil as pitó. This molecule has been shown to have many biological activities, however no study has been carried out to investigate the toxicity of this substance. The present work aimed to evaluate the possible cellular toxicity in silico, in vitro and ex-vivo of the kaempferol-3-O-β-D-(6-E-p-coumaroyl) glucopyranoside (tiliroside), through chemical structure analysis, toxicity assessment and predictive bioactive properties, using human samples for in vitro and ex-vivo tests. The in silico analysis suggests that tiliroside exhibited great absorption index when penetrating biological membranes. In addition, it also displayed considerable potential for cellular protection against free radicals, and anticarcinogenic, antioxidant, antineoplastic, anti-inflammatory, anti-hemorrhagic and antithrombotic activities. The assessment of the ...
Chocolate is known to contain large amounts of saturated fat. However, cacao beans are also rich in natural chemical compounds, called flavanols.
Numerous experimental studies of flavonoids as plant secondary metabolites have revealed their various benefits to human health. These polyphenolic compounds are able to prevent initiation and development of cancer through acting on several molecular targets and influencing different signalling pathways, including those involved in modulation of immune response and inflammatory reactions. This review article gives a survey about flavonoids, their structural and functional diversities and major immunomodulatory activities, but brings forth also the bottlenecks in translating preclinical effects to cancer prevention or therapy in humans. It can be expected that growing interest among general public in the use of flavonoids and food products rich in flavonoids, accompanying with ongoing efforts of scientific community to overcome the current barriers in application of these promising compounds, will further proovide new opportunities for cancer prevention, as well as will expand our current drug ...
Flavonoids are water-soluble polyphenolic molecules that have 15 carbon atoms. They appear as two benzene rings that are connected together ...
The gut microbiota plays a crucial role in the conversion of dietary flavonoids and thereby affects their health-promoting effects in the human host. The ...
The aim of this review is to give a general account on the oxidative microbial degradation of flavonols. Since now 50 years, various research groups have deciphered the way microorganisms aerobically
Kapolres Banjar mengatakan Polres Banjar secara rutin melaksanakan 3T untuk antisipasi penyebaran Covd-19 khususnya di lingkungan Polres Banjar. Tentunya melalui Ur Dokpol (Urusan Kedokteran Kepolisian) Polres Banjar, Kami secara rutin melaksanakan 3T salah satunya dengan Swab test rutin terhadap personel yang bertugas di lapangan, serta treatment terhadap Personel dengan memberikan obat maupun vitamin ucap Kapolres Banjar.Senin (13/07). Dalam situasi pandemi Covid-19 Ur Dokkes Polres Banjar menjadi garda terdepan dalam menghadapi Covid-19.(R.Baskara). ...
Bismillah Ayo pencinta Taman Surga Kembali merapat. Gratis dan terbuka untuk _Mahasiswa Bismillah Hadirilah kajian pembahasan KITAB TAUHID Al-Ushul
... kaempferol; and kaempferol-3-O-β-d-glucoside can be isolated from the methanolic extract of fronds of Phegopteris connectilis. ...
Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans, Eur J Clin Nutr 2004 Jun;58(6):947-54 ... It also contains kaempferol. Jones, Daniel (2011). Roach, Peter; Setter, Jane; Esling, John (eds.). Cambridge English ...
Proanthocyanidins present (cyanidin and delphinidin). Flavonols present (kaempferol and quercetin). The fruits produce 2.5 - 5 ...
It is the rhamnoside of kaempferol. It is found in Nymphaea odorata. Zhang, Z; Elsohly, HN; Li, XC; Khan, SI; Broedel, SE; ...
Flavonols, kaempferol and/or quercetin present. Many of these plants are poisonous. The Mexican prickly poppy is poisonous if ...
Kaempferol 3-O-galactosyltransferase is an enzyme that catalyzes the chemical reaction: UDP-galactose + kaempferol → UDP + ... It is the kaempferol 3-galactoside. It can be found in Camptotheca acuminata, in Euphorbia condylocarpa or in Consolida ... kaempferol 3-O-beta-D-galactoside (trifolin). It can also be found in seedlings of Vigna mungo. Li, S.; Zhang, Z.; Cain, A.; ... with Special Reference to the Formation of Kaempferol 3-O-Galactoside and 3-O-Glucoside". Plant and Cell Physiology. 34 (2): ...
It also contains kaempferol and several derivatives. Baccharane glycosides have been found in Chinese herbal remedies made from ... Hua L, Peng Z, Chia LS, Goh NK, Tan SN (February 2001). "Separation of kaempferols in Impatiens balsamina flowers by capillary ...
Alicia B. Pomilio and Enrique M. Zallocch (1989). "Two New Kaempferol Isorhamninosides from Vigna luteola". Journal of Natural ...
In red grapes, the main flavonol is on average quercetin, followed by myricetin, kaempferol, laricitrin, isorhamnetin, and ... syringetin.[23] In white grapes, the main flavonol is quercetin, followed by kaempferol and isorhamnetin. The delphinidin-like ...
Glycosides of kaempferol. *Afzelin (Kaempferol 3-rhamnoside). *Astragalin (kaempferol 3-O-glucoside) ...
A major phenol was found to be kaempferol 3-O-rutinoside based on chromatographic and mass spectrometry techniques. Gomphrenol ... Other flavonols include quercetin, kaempferol, and isorhamnetin derivatives. The major betacyanins identified in globe amaranth ...
... is a 3-O-glucoside of kaempferol. Phenolic constituents of the fernPhegopteris connectilis. Klaus-Peter Adam, ...
... is the 3,7-dirhamnoside of kaempferol. Hamzah, Ahmad Sazali; Lajis, N. H.; Sargent, M. V. (1994). "Kaempferitrin ...
It is a flavone glycoside based on kaempferol. Robinin and kaempfereol from Vinca erecta V. Akhmedzhanova, 1986 The plant ...
The flower colour derives from the organic compound kaempferol. The tree's bark has limited use in tanning, primarily for ...
Robinin is a kaempferol-3-O-robinoside-7-O-rhamnoside. Reiersen, Bergitte; Kiremire, Bernard T; Byamukama, Robert; Andersen, ...
Flavonoids found in Scorzonera include apigenin, kaempferol, luteolin, and quercetin. Other secondary metabolites reported from ...
Flavonoids such as kaempferol, quercitin and myricetin are often present. Ellagic acid has never been found in any of the ...
V. I. Lutskii, A. S. Gromova and N. A. Tyukavkina (1971). "Aromadendrin, apigenin, and kaempferol from the wood of Pinus ...
The other two were identified as kaempferol derivatives, but could not be more precisely determined due to lack of material; ... "Species-specific kaempferol derivatives in ferns of the Appalachian Asplenium complex". Biochemical Systematics and Ecology. 1 ...
Kaempferol Tanaproget Lim LS, Shen P, Gong YH, Yong EL (2006). "Dimeric progestins from rhizomes of Ligusticum chuanxiong". ...
Plants contain aglycones: apigenin, chrysoeriol, isorhamnetin, kaempferol, luteolin, quercetin and rutin. The fresh plant Viola ...
... kaempferol 3-O-rutinoside-7-O-glucoside, rutin, nicotiflorin, isoquercitrin, quercetin, kaempferol damascenone, choline, ... Other detected compounds include flavonoids derived from myricetin, quercetin, and kaempferol; hexadecanoic acid, linoleic acid ...
Flavonoids (quercetin and kaempferol) and proanthocyanidins (cyanidin and delphinidin) are present. Epicuticular waxes are ...
... and kaempferol. DNA analysis indicated O. ficus-indica was domesticated from Opuntia species native to central Mexico. The ...
... can alternatively be produced directly from kaempferol, which is another flavonol. Antioxidants are molecules present ...
It is the tert-amyl alcohol derivative of kaempferol 7-O-glucoside. It can be found in Phellodendron amurense. 6"'-O-acetyl ...
It is the 8-prenyl derivative of kaempferol 3,7-O-diglucoside. The compound has been isolated from several species of plant ...
Dabeek WM, Marra MV (2019). "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity ...
Other compounds identified in the fruit include the polyphenols, luteolin, and kaempferol. In late 2012, a United States ...
Kaempferol is named for 17th-century German naturalist Engelbert Kaempfer. Kaempferol is a secondary metabolite found in many ... Kaempferol is common in Pteridophyta, Pinophyta and Angiospermae. Within Pteridophyta and Pinophyta, kaempferol has been found ... DuPont MS, Day AJ, Bennett RN, Mellon FA, Kroon PA (June 2004). "Absorption of kaempferol from endive, a source of kaempferol-3 ... Kaempferol is a yellow crystalline solid with a melting point of 276-278 °C (529-532 °F). It is slightly soluble in water and ...
... 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-chromen-4-one kaempferol-3-glucoside
Kaempferol-3-O-rutinoside is a bitter-tasting flavonol glycoside. It can be isolated from the rhizomes of the fern Selliguea ... doi:10.1016/S0031-9422(00)97105-X. INIST:3300075 Kaempferol-3-O-rutinoside at www.phenol-explorer.eu v t e. ...
kaempferol 3-O-β-D-glucoside (CHEBI:30200) is a kaempferol O-glucoside (CHEBI:64634) kaempferol 3-O-β-D-glucoside (CHEBI:30200 ... kaempferol 3-O-β-D-glucoside (CHEBI:30200) has role plant metabolite (CHEBI:76924) kaempferol 3-O-β-D-glucoside (CHEBI:30200) ... A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a β-glycosidic linkage.. ... CHEBI:30200 - kaempferol 3-O-β-D-glucoside. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ...
This topic has 22 study abstracts on Kaempferol indicating that it may have therapeutic value in the treatment of Brain Cancer ... This article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food ... Kaempferol can safely inhibit the metastasis of the 786-O RCC cells into the lungs by about 87.4%.Dec 31, 2016. ... Substances : Kaempferol, Persimmon , Quercetin. Diseases : Endothelial Damage, Hydrogen Peroxide Induced Toxicity, Oxidative ...
Rationale: Kaempferol was nominated on the basis of its potential for carcinogenicity and to represent the flavonoid compounds ... Kaempferol has demonstrated activity in several microbial and mammalian cell genotoxicity tests, but has not been adequately ... Kaempferol occurs in the commercially used wood Afzelia and has been detected in numerous vegetables and fruits. ...
Kaempferol 3-β-D-glucopyranoside, 3,4′,5,7-Tetrahydroxyflavone 3-glucoside, 3-(β-D-Glucopyranosyloxy)-5,7-dihydroxy-2-(4- ... methoxyphenyl)-4H-1-benzopyran-4-one, 3-Glucosylkaempferol, Astragalin, Kaempferol 3-glucoside; Linear Formula: C21H20O11; find ... Kaempferol 3-glucoside analytical standard Synonym: 3,4′,5,7-Tetrahydroxyflavone 3-glucoside, 3-(β-. D. -Glucopyranosyloxy)-5,7 ... 2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 3-Glucosylkaempferol, Astragalin, Kaempferol 3-β-. D. -glucopyranoside, Kaempferol 3 ...
Kaempferol-7-O-glucoside, tms- , C42H76O11Si7 , CID 554000 - structure, chemical names, physical and chemical properties, ...
Kaempferol 7-O-glukozid je organsko jedinjenje, koje sadrži 21 atom ugljenika i ima molekulsku masu od 448,377 Da. ... Dobavljeno iz "https://sh.wikipedia.org/w/index.php?title=Kaempferol_7-O-glukozid&oldid=33638309" ...
Biological Activities of Kaempferol: Effect of Cyclodextrins Complexation on the Properties of Kaempferol. (M.T. Mercader-Ros, ... Topics include the effect of cyclodextrins complexation on the properties of kaempferol; kaempferitrin and kaempferol as ... metal complexes of kaempferol and their speciation in human plasma; the action of kaempferol on oral cavity cancer and airway ... chemoprotective effects of kaempferol in colorectal tumorigenesis; multipotent flavonoid kaempferol as molecular targets and ...
Kaempferol, a yellow-colored powder, is a flavonoid that can be found in various natural resources such as apples, onions, ... Medicinal uses for kaempferol. Kaempferol has been found to have hypoglycemic and antioxidant effects. The phytonutrient was ... Body systems supported by kaempferol. Aside from its cancer-fighting properties, kaempferol acts as an antioxidant and protects ... Kaempferol, a yellow-colored powder, is a flavonoid that can be found in various natural resources such as apples, onions, ...
Kaempferol primary reference standard; CAS Number: 520-18-3; EC Number: 208-287-6; Synonym: 3,4′,5,7-Tetrahydroxyflavone, 3,5,7 ... Kaempferol primary reference standard Synonym: 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-. Trihydroxy-. 2-. (4-. hydroxyphenyl). -. 4 ... The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol. ...
VELLOSA, José Carlos Rebuglio et al. Antioxidant and cytotoxic studies for kaempferol, quercetin and isoquercitrin. Eclet. Quím ... aim of the present study was to investigate a cytotoxic oxidative cell stress related and the antioxidant profile of kaempferol ...
3-neohesperidosidefor price inquiry.where to buy Kaempferol 3-neohesperidoside.Also offer free database of Kaempferol 3- ... Kaempferol 3-neohesperidoside Specification. The Kaempferol 3-neohesperidoside, with the CAS registry number 32602-81-6, is ... Physical properties of Kaempferol 3-neohesperidoside: (1)ACD/LogP: 0.77; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5 ... Find quality suppliers and manufacturers of Kaempferol ...
Quercetin, kaemp-ferol and biapigenin significantly reduced neuronal death caused by 100 μM kainate plus 100 μMN-methyl-D- ... Samhan-Arias AK, FJ Martín-Romero and C Gutiérrez-Merino (2004) Kaempferol blocks oxidative stress in cerebellar granule cells ... Taken together, the results suggest that the neuroprotective action induced by quercetin and kaempferol are mainly mediated by ... Quercetin, kaempferol and biapigenin fromhypericum perforatum are neuroprotective against excitotoxic insults. ...
... cells and its mechanism. ... The quercetin and kaempferol induced G(2)/M arrest and apoptosis of HL-60 cells. The quercetin and kaempferol could down- ... and kaempferol (r = 0.76) respectively, and the cytotoxicity of quercetin was superior to that of kaempferol. ... Substances : Kaempferol : CK(102) : AC(65), Quercetin : CK(846) : AC(392). Diseases : Leukemia: Acute promyelocytic leukemia : ...
Buy Kaempferol - CAS Number 520-18-3 from LGC Standards. Please login or register to view prices, check availability and place ...
DuPont MS, Day AJ, Bennett RN, Mellon FA and Kroon PA: Absorption of kaempferol from endive, a source of kaempferol-3- ... Kuo W, Tsai Y, Wu H, Ho Y, Chen Y, Yao C and Yao C: Radiosensitization of non-small cell lung cancer by kaempferol. Oncol Rep ... Nguyen TT, Tran E, Ong CK, Lee SK, Do PT, Huynh TT, Nguyen TH, Lee JJ, Tan Y, Ong CS, et al: Kaempferol-induced growth ... Treatment with kaempferol inhibited the growth of A-549 cells through activation of apoptotic pathway. However, the same doses ...
Here, we describe kaempferol, a small molecule with anti-biofilm activity that specifically inhibited the formation of S. ... Kaempferol inhibited the primary attachment phase of biofilm formation, as determined by a fibrinogen-binding assay. Moreover, ... Kaempferol inhibited the primary attachment phase of biofilm formation, as determined by a fibrinogen-binding assay. Moreover, ... Based on these results, kaempferol provides a starting point for the development of novel anti-biofilm drugs, which may ...
Kaempferol, a natural flavonoid, has shown promise in the chemoprevention of ovarian cancer. A common concern about using ... On the other hand, PEO-PPO-PEO nanoparticles incorporating kaempferol were more effective inhibitors of cancer cells, but they ... Both PEO-PPO-PEO and PLGA nanoparticle formulations had superior effects compared with kaempferol alone in reducing cancer cell ... PEO-PPO-PEO nanoparticles incorporating kaempferol may be suitable as a cancer-targeting strategy, which could limit the ...
Kaempferol is a natural flavonol, a type of flavonoid that can be found in many fruits and vegetables, including: Brussels ... Li, studies in the Netherlands have shown that women who ate endive (a good source of kaempferol) had a 75% reduction in the ... Kaempferol and an Anti-Ovarian Cancer "Green" Smoothie. posted on January 6, 2012 by Adventuresgfmom ... Kaempferol enhances cisplatins effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. ...
Buy KaempferoL-4-glucoside - CAS Number 52222-74-9 from LGC Standards. Please login or register to view prices, check ...
Kaempferol is a natural flavonol-type flavonoid that has been isolated from plant sources. Kaempferol effectively suppresses ... Moreover, kaempferol encumbered the OVA challenge-inflamed Tyk2-STAT3 activation. Therefore, kaempferol was effective in ... μM kaempferol inhibited the induction of TLR4 triggered by LPS. When BEAS-2B cells were incubated with ≤20 μM kaempferol for 24 ... by kaempferol in LPS-stimulated BEAS-2B cells. BEAS-2B cells were treated with 1-20 μM kaempferol in the absence and presence ...
Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial ... Kapil Suchal, Salma Malik, Nanda Gamad, et al., "Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK ...
Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa ... Kaempferol-7-O-beta-D-glucoside (KG), a flavonoid glycoside, isolated from Smilax china L. rhizome, displayed marked anticancer ... kaempferol-3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1- 2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside ...
Orlistat and kaempferol (14 µM) strongly inhibited CpLIP2 catalytic activity within 1 min of pre-incubation, by 90% and 80%, ... The results suggested that orlistat bound to the catalytic site while kaempferol interacted with W294 on the protein lid. A ... The inhibition effects of orlistat and four flavonols (galangin, kaempferol, quercetin and myricetin) characterized by an ... The relative potency of flavonols as inhibitors was: kaempferol , quercetin , myricetin , galangin. ...
Kaempferol-3-O-rutinoside, which demonstrated a 48.2% inhibitory effect on adipogenesis without cytotoxicity, was isolated from ... PPAR-γ and C/EBPα expression levels were determined using western blot, and our results indicate that kaempferol-3-O-rutinoside ... Keywords: obesity; screening; Solidago virgaurea; kaempferol-3-O-rutinoside obesity; screening; Solidago virgaurea; kaempferol- ... Kaempferol-3-O-rutinoside, which demonstrated a 48.2% inhibitory effect on adipogenesis without cytotoxicity, was isolated from ...
... followed by kaempferol (OATP1A2: 25.2μM, OATP2B1: 15.1μM) and apigenin (OATP1A2: 32.4μM OATP2B1: 20.8μM). Apigenin, kaempferol ... Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 ... kaempferol (IC(50) for OATP1A2: 37.3μM, OATP2B1: 20.7μM) and quercetin (IC(50) for OATP1A2: 13.5μM, OATP2B1: 14.1μM). These ... kaempferol, and quercetin on the transport activity of OATP1A2 and OATP2B1. K(i) values of all three flavonoids determined from ...
kaempferol-3-O-(6,4-di-p-coumaroyl)mannopyranoside: isolated from the flower of Castanea mollissima; structure in first ... kaempferol- 3- O- (6,4- di- p- coumaroyl)mannopyranoside. Subscribe to New Research on kaempferol-3-O-(6,4-di-p- ... castanoside B; kaempferol-3-O-(6,4-di-(E)-p-coumaroyl)-alpha-D-mannopyranoside ...
Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co- ... Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co- ... The total amount of methyl, sulphate and glucuronide conjugates was in the order: galangin , quercetin , kaempferol , myricetin ... of quercetin and kaempferol. The results show that the lipid matrix has the potential to modify both transport and conjugation ...
  • Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. (greenmedinfo.com)
  • The present study aimed to examine the effect of kaempferol on high glucose‑induced human retinal endothelial cells (HRECs) in vitro. (spandidos-publications.com)
  • The aim of the present study was to evaluate the effect of kaempferol on the inflammatory molecules such as E-selectin (E-sel), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesionmolecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1) in high cholesterol induced atherosclerosis rabbit models. (biomedcentral.com)
  • Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated from Opuntia ficus-indica var. (semanticscholar.org)
  • This study aimed to evaluate the protective effect of kaempferol against myocardial ischemia/reperfusion (I/R) injury in rats. (nih.gov)
  • This study will determine whether effect of kaempferol on the mineralization process of osteoblasts is mediated by estrogen receptors (ERs) and not by a Wnt/β-catenin signaling pathway. (biomedcentral.com)
  • Dietary flavonoid kaempferol inhibits glucocorticoid-induced bone loss by promoting osteoblast survival. (greenmedinfo.com)
  • These results indicate that kaempferol inhibits synovial fibroblast proliferation, as well as the production of and MMPs, COX‑2 and PGE2, which is involved in articular inflammation and destruction in rheumatoid arthritis (RA). (unboundmedicine.com)
  • In conclusion, kaempferol inhibits human osteosarcoma cells in vivo and in vitro. (nih.gov)
  • Our objective was to investigate whether kaempferol inhibits Bcrp-mediated quercetin efflux and determine whether it is a substrate for BCRP. (nih.gov)
  • We report for the first time that kaempferol is a Bcrp substrate, and our results indicate that kaempferol inhibits Bcrp-mediated quercetin efflux. (nih.gov)
  • Kaempferol, a compound extracted from Ginkgo biloba, inhibits cell proliferation and induces programmed cell death in pancreatic cancer cells, in vitro. (greenmedinfo.com)
  • Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. (greenmedinfo.com)
  • CONCLUSIONS: Ginkgo biloba extract kaempferol effectively inhibits pancreatic cancer cell proliferation and induces cancer cell apoptosis, which may sensitize pancreatic tumor cells to chemotherapy. (greenmedinfo.com)
  • In the present study for the first time we have reported the anticancer activity of SsnB and have shown that SsnB inhibits the growth of human being neuroblastoma cells of different genetic background by arresting cell cycle progression and by inducing apoptotic cell death through generation of reactive oxygen Kaempferol species. (markterest.com)
  • 2) Studies have also confirmed that kaempferol acts as achemopreventive agent, which means that it inhibits the formation of cancer cells.Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. (sxgreenfine.com)
  • Kaempferol induced G2/M cell cycle arrest and the enhancement of radiation-induced death and clonogenic survival inhibition. (spandidos-publications.com)
  • In conclusion, the findings demonstrated that kaempferol increased tumor cell killing by radiation in vitro and in vivo through inhibition of the AKT/PI3K and ERK pathways and activation of the mitochondria apoptosis pathway. (spandidos-publications.com)
  • Here we developed five different types of nanoparticles incorporating kaempferol and tested their efficacy in the inhibition of viability of cancerous and normal ovarian cells. (dovepress.com)
  • Similar inhibition of Tyk2 activation by kaempferol was observed in OVA-induced mice. (hindawi.com)
  • Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury," Oxidative Medicine and Cellular Longevity , vol. 2016, Article ID 7580731, 10 pages, 2016. (hindawi.com)
  • The inhibition effects of orlistat and four flavonols (galangin, kaempferol, quercetin and myricetin) characterized by an increasing degree of hydroxylation in B-ring, were investigated using ethyl oleate hydrolysis as the model reaction. (mdpi.com)
  • K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0μM) and OATP2B1 (8.7μM) followed by kaempferol (OATP1A2: 25.2μM, OATP2B1: 15.1μM) and apigenin (OATP1A2: 32.4μM OATP2B1: 20.8μM). (nih.gov)
  • The anti-cancer effects of kaempferol in vivo are evaluated in BALB/c(nu/nu) mice inoculated with U-2 OS cells, and the results indicate inhibition of tumor growth. (nih.gov)
  • Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK. (banglajol.info)
  • Combination treatment of low concentrations of kaempferol and 5-fluorouracil showed an additive effect on the inhibition of MIA PaCa-2 cell proliferation. (greenmedinfo.com)
  • Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3β. (nih.gov)
  • These results suggested that kaempferol provides cardioprotection via antioxidant activity and inhibition of GSK-3β activity in rats with I/R. (nih.gov)
  • Such Kaempferol reversible enzyme inhibition a wide spectral range of HGF/c-Met activities resulted in the analysis of both gene appearance and c-Met activity in tumor cells. (capecodmushroom.org)
  • Actually, c-Met is certainly deregulated in lots of types of individual malignancies, kidney, liver organ, Kaempferol reversible enzyme inhibition stomach, brain and breast cancers. (capecodmushroom.org)
  • Renal cell carcinomas (RCC) are split into many major subtypes: the most frequent is certainly very clear cell RCC (ccRCC, Kaempferol reversible enzyme inhibition 75% of situations), papillary RCC (pRCC 15%) and chromophobe RCC (5%) [20]. (capecodmushroom.org)
  • The inhibition mode of quercetin and kaempferol were competitive towards both catecholase and cresolase activities of the enzyme. (biotech-health.com)
  • In general, quercetin and kaempferol can be used as good candidates in melanogenesis inhibition. (biotech-health.com)
  • These data suggested that kaempferol protects sinus node via inhibition of CaMKII oxidization and may be useful for preventing SND in high risk patients . (bvsalud.org)
  • The flavonoids quercetin and kaempferol are major constituents of Ginkgo biloba extract. (nih.gov)
  • This includes the flavonoids quercetin and kaempferol, which are found in relatively large amounts in kale ( 5 ). (healthline.com)
  • On the other hand, PEO-PPO-PEO nanoparticles incorporating kaempferol were more effective inhibitors of cancer cells, but they also significantly reduced the viability of normal cells. (dovepress.com)
  • In addition, pretreating cells with caspase inhibitors, BAPTA or calpeptin before exposure to kaempferol increases cell viabilities. (nih.gov)
  • The intracellular uptake of kaempferol, with and without specific inhibitors, was determined in Bcrp-expressing cells. (nih.gov)
  • In the present study the activity of this enzyme was examined against quersetin and kaempferol as two potentially flavonoid inhibitors. (biotech-health.com)
  • The purpose of this study was to determine the effect of certain commonly consumed lipids, soybean, olive and corn oil, on the transport and conjugation of flavonols (myricetin, quercetin, kaempferol and galangin) using the conjugation-competent co-cultured Caco-2/HT29-MTX intestinal cell monolayer model. (rsc.org)
  • Acts on the endogenous flavonols kaempferol and quercetin, to a lesser extent on myricetin and fisetin, and weakly on galangin and isorhamnetin. (creative-enzymes.com)
  • Quantitative phytochemical characterisation of the chief flavonoid aglycones in the hydrolysed Lysimachia extracts revealed the dominance of kaempferol, quercetin and myricetin in L. vulgaris, L. nummularia, L. punctata, L. christinae, L. ciliata and L. clethroides, respectively. (usda.gov)
  • In an investigation of moringa oleifera leaf extract, which contains quercetin and kaempferol, it was found that the leaf extracts from the plant had strong antiproliferation and potent induction of apoptosis. (naturalpedia.com)
  • The quercetin and kaempferol induced G(2)/M arrest and apoptosis of HL-60 cells. (greenmedinfo.com)
  • Furthermore the apoptosis-inducing effect of quercetin is stronger than that of kaempferol, both of which induce apoptosis of HL-60 cells through depressing cell growth, arresting cell cycle and inhibiting expression of survivin. (greenmedinfo.com)
  • The in vivo data showed that kaempferol increased tumor cell apoptosis and killing of radiation. (spandidos-publications.com)
  • Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independe. (nih.gov)
  • Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. (nih.gov)
  • Previous studies have reported that kaempferol has anti-proliferation activities and induces apoptosis in many cancer cell lines. (nih.gov)
  • Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. (banglajol.info)
  • Li W, Du B, Wang T, Wang S, Zhang J. Kaempferol induces apoptosis in human HCT116 colon cancer cells via the ataxia-telangiectasia mutated-p53 pathway with the involvement of p53 up-regulated modulator of apoptosis. (banglajol.info)
  • Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of Its Induction of Apoptosis on Bladder Cancer. (greenmedinfo.com)
  • In this paper, we evaluated the antioxidant and anticancer activities of kaempferol and its mechanism of induction to apoptosis on bladder cancer cells. (greenmedinfo.com)
  • We found that Kaempferol exhibited strong anti-oxidant activity on erythrocyte and inhibitory effects on the growth of cancerous bladder cells through inducing apoptosis and S phase arrest. (greenmedinfo.com)
  • The objective of this study was to determine the effect and mechanisms of kaempferol on pancreatic cancer cell proliferation and apoptosis. (greenmedinfo.com)
  • J. M. Calderon-Montano, E. Burgos-Moron, C. Perez-Guerrero and M. Lopez-Lazaro, " A Review on the Dietary Flavonoid Kaempferol", Mini-Reviews in Medicinal Chemistry (2011) 11: 298. (eurekaselect.com)
  • Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review. (ac.ir)
  • One of the flavonoids - quercetin - was, as expected, measurably higher in the organically grown bell peppers (by about 10%, just like carotenoids and vitamin C). However, levels of another flavonoid - kaempferol- depended as much on the specific variety of bell pepper as the growing method. (whfoods.org)
  • Kaempferol, a natural flavonoid, has shown promise in the chemoprevention of ovarian cancer. (dovepress.com)
  • Kaempferol is a natural flavonoid. (nih.gov)
  • Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources. (sxgreenfine.com)
  • Our findings demonstrated that kaempferol showed an obvious radical scavenging activity in erythrocytes damaged by oxygen. (greenmedinfo.com)
  • Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. (foodb.ca)
  • Another study found that kaempferol, together with other flavonoids such as apigenin and luteolin, has analgesic and anti-inflammatory effects contained in the Cassia siamea Lam. (naturalpedia.com)
  • Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. (nih.gov)
  • Therefore, HEK293 cell lines stably expressing OATP1A2 and OATP2B1 were used to investigate the influence of the Ginkgo flavonoids apigenin, kaempferol, and quercetin on the transport activity of OATP1A2 and OATP2B1. (nih.gov)
  • Apigenin, kaempferol, and quercetin led to a concentration-dependent decrease of the OATP1A2-mediated fexofenadine transport with IC(50) values of 4.3μM, 12.0μM, and 12.6μM, respectively. (nih.gov)
  • The OATP1A2- and OATP2B1-mediated transport of atorvastatin was also efficiently inhibited by apigenin (IC(50) for OATP1A2: 9.3μM, OATP2B1: 13.9μM), kaempferol (IC(50) for OATP1A2: 37.3μM, OATP2B1: 20.7μM) and quercetin (IC(50) for OATP1A2: 13.5μM, OATP2B1: 14.1μM). (nih.gov)
  • These data indicate that modification of OATP1A2 and OATP2B1 transport activity by apigenin, kaempferol, and quercetin may be a mechanism for food-drug or drug-drug interactions in humans. (nih.gov)
  • Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. (creative-enzymes.com)
  • The inhibitory effects of quercetin and kaempferol on growth of HL-60 cells was assessed by MTT assay. (greenmedinfo.com)
  • The in vitro study elucidated inhibitory effects of kaempferol, a flavonoid found in apples and many berries, on inflammation in human airway epithelial BEAS-2B cells. (hindawi.com)
  • MATERIALS AND METHODS: Pancreatic cancer cell lines MIA PaCa-2 and Panc-1 were treated with kaempferol, and the inhibitory effects of kaempferol on pancreatic cancer cell proliferation were examined by direct cell counting, 3H-thymidine incorporation, and MTS assay. (greenmedinfo.com)
  • Taherkhani N, Gheibi N. Inhibitory Effects of Quercetin and Kaempferol as two Propolis Derived Flavonoids on Tyrosinase Enzyme, Biotech Health Sci. (biotech-health.com)
  • Our data suggest that kaempferol may be a novel therapeutic agent for the treatment of RA. (unboundmedicine.com)
  • The results of this study suggest that kaempferol targets ERRα and suppresses the angiogenesis of HRECs under high glucose conditions. (spandidos-publications.com)
  • The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol. (sigmaaldrich.com)
  • In this study, we investigate the anti-cancer effects and molecular mechanisms of kaempferol in human osteosarcoma cells. (nih.gov)
  • Consistently, oral administration of kaempferol blocked STAT3 transactivation elevated by OVA challenge. (hindawi.com)
  • The aim of the present study was to determine whether kaempferol has a radiosensitization potential for lung cancer in vitro and in vivo. (spandidos-publications.com)
  • The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. (banglajol.info)
  • Although stimulation with kaempferol alone induced ABCA1 expression to high levels, its ability to reduce TNF-α inhibitory response was the weakest amongst the three antioxidants. (alliedacademies.org)
  • I knew that it was because of flavonoid antioxidants but I didn't know that the specific flavonoid is called kaempferol. (infobloom.com)
  • Many powerful antioxidants are found in kale, including quercetin and kaempferol, which have numerous beneficial effects on health. (healthline.com)
  • Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. (dmu.ac.uk)
  • The antioxidants crocin and kaempferol were purified by flash column chromatography, and identified by thin layer chromatography (TLC), HPLC-DAD, infrared (IR), and nuclear magnetic resonance (1H & 13C NMR) spectroscopy. (dmu.ac.uk)
  • Zeka K., Ruparelia K.C., Continenza M.A., Stagos D., Vegliò F., Arroo R.R.J. (2015) Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. (dmu.ac.uk)
  • The in vitro radio-sensitization activity of kaempferol was elucidated in A-549 lung cancer cells by using an MTT (3-(4 5-dimethylthiazol-2-yl)-25-diphenyl-tetrazolium bromide) assay, cell cycle analysis and clonogenic assay. (spandidos-publications.com)
  • Kaempferol inhibited the primary attachment phase of biofilm formation, as determined by a fibrinogen-binding assay. (frontiersin.org)
  • Moreover, a fluorescence resonance energy transfer (FRET) assay and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) analyses revealed that kaempferol reduced the activity of S. aureus sortaseA (SrtA) and the expression of adhesion-related genes. (frontiersin.org)
  • Kaempferol-3- O -rutinoside, which demonstrated a 48.2% inhibitory effect on adipogenesis without cytotoxicity, was isolated from the butanol layer of a water extract of S. virgaurea guided by the anti-adipogenesis assay in 3T3-L1. (mdpi.com)
  • The proliferation of the RASFs stimulated with IL-1β and treated with/without kaempferol was evaluated by CCK-8 assay. (unboundmedicine.com)
  • Western blotting and fluorogenic enzymatic assay show that kaempferol treatment influences the time-dependent expression of proteins involved in the endoplasmic reticulum stress pathway and mitochondrial signaling pathway. (nih.gov)
  • The target of kaempferol was determined using a luciferase reporter assay. (spandidos-publications.com)
  • The luciferase reporter assay demonstrated that kaempferol inhibited ERRα activity in HRECs. (spandidos-publications.com)
  • Kaempferol-3-O-rutinoside analytical standard provided with w/w absolute assay, to be used for quantitative titration. (extrasynthese.com)
  • Five-day-old Arabidopsis seedlings are soaked in a solution containing DPBA and latterly the flavonols (kaempferol and quercetin) can be observed under a confocal microscope. (bio-protocol.org)
  • Here we tested the flavonols kaempferol, kaempferol glycosides, and acylated kaempferol glucoside derivatives with respect to their potency to block the 3a channel. (unifi.it)
  • This could make kaempferol 3-(6''-acetylgalactoside) 7-rhamnoside a potential biomarker for the consumption of these foods. (hmdb.ca)
  • Kaempferol is a biomarker for the consumption of dried and cooked beans. (foodb.ca)
  • Kaempferol 3-o-(2''-rhamnosyl-galactoside) 7-o-rhamnoside can be found in broad bean, which makes kaempferol 3-o-(2''-rhamnosyl-galactoside) 7-o-rhamnoside a potential biomarker for the consumption of this food product. (foodb.ca)
  • Kaempferol has a unique ability to protect osteoblasts (bone building cells) from damage, even in the presence of harmful substances. (saveourbones.com)
  • Effects of Parsley (Petroselinum crispum) and its Flavonol Constituents, Kaempferol and Quercetin, on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Liver Xanthine Oxidoreductase Aactivity in Oxonate-Induced Hyperuricemic Rats', Iranian Journal of Pharmaceutical Research , Volume 10(4), pp. 811-819. (ac.ir)
  • The aim of this study was to investigate the effect of parsley, quercetin and kaempferol on serum uric acid levels, liver xanthine oxidoreductase activity and two non-invasive biomarkers of oxidative stress (total antioxidant capacity and malondialdehyde concentration) in normal and oxonate-induced hyperuricemic rats. (ac.ir)
  • This study aims to investigate whether kaempferol affects systemic inflammation and oxidative stress in the heart, lung, and liver after hemorrhagic shock in mice. (biomedcentral.com)
  • The purpose of this study was to explore the anti-leukemia effect of quercetin and kaempferol and its mechanism. (greenmedinfo.com)
  • Intestinal efflux by Bcrp may represent one possible mechanism for the low bioavailability of kaempferol. (nih.gov)
  • Kaempferol (KPF) is a flavonoid with antiparasitic activity including experimental giardiasis which mechanism of action is unknown. (bvsalud.org)
  • Of all the residues tested, nitrogenous nucleophile, for example, imidazole, was observed to be able to facilitate the electron transfer of kaempferol, and the mechanism was also proposed. (umn.edu)
  • However, the precise mechanism of action of kaempferol on bone homeostasis is not clearly known. (biomedcentral.com)
  • In traditional Chinese language Kaempferol medication (TCM) the tubers of the herb have already been used for the treating several inflammatory illnesses as well as the crude remove prepared type this herb provides anti-spasmodic and anti-tumor properties [4]-[6]. (markterest.com)
  • It's the many common cancers in babies youthful than Kaempferol one and Kaempferol second many common tumor in kids [11] [12]. (markterest.com)
  • Kaempferol is a polyphenol that is a type of flavonoid, known as a flavonol . (infobloom.com)
  • The in vivo study explored the demoting effects of kaempferol on asthmatic inflammation in BALB/c mice sensitized with ovalbumin (OVA). (hindawi.com)
  • In this work, the electron transfer reactivity of kaempferol was studied and the interaction in vivo between kaempferol and protein was simulated. (umn.edu)
  • The current work describes the formulation and evaluation of a phospholipid complex of kaempferol toenhance the latter's aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotectiveactivities, and oral bioavailability. (sjfc.edu)
  • The in vivo antioxidant properties of the kaempferol-phospholipid complex wereevaluated by measuring its impact on carbon tetrachloride (CCl4)-intoxicated rats. (sjfc.edu)
  • The complex also enhanced the in vivo antioxidantpotential by increasing levels of GSH (reduced glutathione), SOD (superoxide dismutase), catalase anddecreasing lipid peroxidation, compared to that of pure kaempferol. (sjfc.edu)
  • Kaempferol 3-(6''-acetylgalactoside) 7-rhamnoside is an extremely weak basic (essentially neutral) compound (based on its pKa). (hmdb.ca)
  • The structure of the compound was found to be that of kaempferol- 3-O- - D 6{P-coumaroyl} glucopyranoside. (eurekaselect.com)
  • Kaempferol 3-o-(2''-rhamnosyl-galactoside) 7-o-rhamnoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). (foodb.ca)
  • Kaempferol is a yellow crystalline solid with a melting point of 276-278 °C (529-532 °F). It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. (wikipedia.org)
  • Kaempferol has been found to have hypoglycemic and antioxidant effects . (naturalpedia.com)
  • A study also found out that upon the investigation of neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, kaempferol prevented the loss of TH-positive neurons induced by MPTP, a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease. (naturalpedia.com)
  • Taken together, the results suggest that the neuroprotective action induced by quercetin and kaempferol are mainly mediated by antioxidant effects, whereas biapigenin mainly affects mitochondrial bioenergetics and calcium uptake. (springer.com)
  • PEO-PPO-PEO nanoparticles incorporating kaempferol may be suitable as a cancer-targeting strategy, which could limit the effects of the nanoparticles on normal cells while retaining their potency against cancer cells. (dovepress.com)
  • Both PEO-PPO-PEO and PLGA nanoparticle formulations had superior effects compared with kaempferol alone in reducing cancer cell viability. (dovepress.com)
  • The aim of the present study was to determine the effects of kaempferol on the interleukin-1β (IL-1β)-induced proliferation of RASFs and the production of MMPs, COX and prostaglandin E2 (PGE2) by RASFs. (unboundmedicine.com)
  • The present study was carried out to investigate protective effects of Kaempferol (KPF) against A-induced toxicity in rats. (antiox.org)
  • Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target. (bvsalud.org)
  • Kaempferol, a flavonol derived from the rhizome of Kaempferia galanga L., is a well-known phytoestrogen possessing osteogenic effects that is also found in a large number of plant foods. (biomedcentral.com)
  • Kaempferol was first evaluated for its estrogenic properties, including its effects on estrogen receptors. (biomedcentral.com)
  • The osteogenic properties of kaempferol were further determined its induction effects on specific osteogenic enzymes and genes as well as the mineralization process in cultured rat osteoblasts. (biomedcentral.com)
  • ER mediation of the kaempferol-induced effects was confirmed by pretreatment of the osteoblasts with an ER antagonist, ICI 182,780, which fully blocked the induction effect. (biomedcentral.com)
  • In this work, the effects of quercetin and kaempferol as propolis-derived compounds on activity of mushroom tyrosinase (MT) were studied. (biotech-health.com)
  • Kaempferol is one of the most important herbal active constituent with antinociceptive effects. (ac.ir)
  • The aim of this study was to evaluate the effects of intracerebroventricular injection of kaempferol and its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) on pain in male rats. (ac.ir)
  • Co-administration of capsaicin and kaempferol (1.5 mg/ rat) had significant analgesic effects compared to the control/DMSO groups although, not a synergist. (ac.ir)
  • Moreover, co-administration of capsazepine and kaempferol (1.5 mg/ rat) mostly decreased antinociceptive effects of kaempferol. (ac.ir)
  • The kaempferol probably has both acute and inflammatory antinociceptive effects and exert this activity at least in part by activating TRPV1 receptors. (ac.ir)
  • This study investigated the molecular mechanisms underlying the cardioprotective effects of kaempferol in sinus node dysfunction (SND) heart . (bvsalud.org)
  • 2. Kaempferol-3-O-β-d-galactoside has antioxidant activity. (chemfaces.com)
  • Petals of C. sativus L. have commercial potential as a source for kaempferol and crocetin glycosides, natural compounds with antioxidant activity that are considered to be the active ingredients in saffron-based herbal medicine. (dmu.ac.uk)
  • The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. (eurekaselect.com)
  • The results showed that the quercetin and kaempferol had a significant anti-leukemia effect in vitro. (greenmedinfo.com)
  • It is concluded that the quercetin and kaempferol have significant anti-leukemia effect in vitro. (greenmedinfo.com)
  • The aqueous solubility and the in vitro dissolution rate were enhanced comparedto that of pure kaempferol. (sjfc.edu)
  • Kaempferol-7-O-beta-D-glucoside (KG), a flavonoid glycoside, isolated from Smilax china L. rhizome, displayed marked anticancer activity on a panel of established cancer cells, of which, HeLa human cervix carcinoma cells were the most sensitive. (nih.gov)
  • Kaempferol 3- O- β-D-glucopyranosides that are di-acylated may be further explored for their chemopreventive and anticancer properties due to their significant antioxidant and cytotoxic properties. (springer.com)
  • Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer. (banglajol.info)
  • If you are looking for low price and high quality GMP, KOSHER and ISO certified benefits kaempferol for anticancer, or you want to buy 100% pure natural, hat sale and organic factory supply benefits kaempferol for anticancer from a famous China factory, please feel free to contact us. (sxgreenfine.com)
  • PPAR-γ and C/EBPα expression levels were determined using western blot, and our results indicate that kaempferol-3- O -rutinoside has a strong anti-adipogenic effect in 3T3-L1 cells through the suppression of increases in PPAR-γ and C/EBPα expression. (mdpi.com)
  • Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. (banglajol.info)
  • Similarly, the treatment with kaempferol significantly inhibited Panc-1 cell proliferation. (greenmedinfo.com)
  • We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents, and that, in particular, kaempferol glycosides are good candidates for 3a channel proteins of coronaviruses. (unifi.it)
  • By contrast, mouse muscle fibres did not respond unless channel-opening drugs were present at purchase Kaempferol substantial concentrations, an observation contrary to the physiological involvement of CICR in mammalian excitationCcontraction coupling. (baxkyardgardener.com)
  • Kaempferol has demonstrated activity in several microbial and mammalian cell genotoxicity tests, but has not been adequately tested for carcinogenicity. (nih.gov)
  • Another study found that Kaempferol-3-O-sophoroside (KPOS) possessed barrier integrity activity, inhibitory activity on cell adhesion, and migration to endothelial cells by blocking the activation of NF-κB expression and production of TNF-α which then endorsed its usefulness as therapy for vascular inflammatory diseases. (naturalpedia.com)
  • In a study, it was found out that flavonols quercetin and kaempferol significantly increased alkaline phosphate (ALP) activity which then can stimulate osteoblastic activity. (naturalpedia.com)
  • Here, we describe kaempferol, a small molecule with anti-biofilm activity that specifically inhibited the formation of S. aureus biofilms. (frontiersin.org)
  • Meanwhile, the minimum inhibitory concentration (MIC) and growth curve results indicated that kaempferol had no antibacterial activity against the tested bacterial strain. (frontiersin.org)
  • Metabolic activity is unstable in primary hepatocyte cultures and is influenced by the matrix composition.The effect of incorporating 20% chondroitin-6-sulphate(Ch6SO4), a glycosaminoglycan, into collagen films and gels(0.3%w/v), and crosslinking the films and gels with 1,6-diaminohexane(DAH)on the glucuronidation of kaempferol by primary rat hepatocytes cultured for 48h and 7 days was investigated. (strath.ac.uk)
  • However, comparing to the model rabbits, levels of TNF-α, IL-1β and MDA decreased significantly and serum SOD activity increased, gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol. (biomedcentral.com)
  • 1. Kaempferol-3-O-β-d-galactoside, isolated from the aerial part of Calluna vulgaris L, has anti-inflammatory and antinociceptive activity. (chemfaces.com)
  • Experimental results revealed that the redox activity of kaempferol was different in aprotic medium DMSO from that in water, and a new redox process was further found. (umn.edu)
  • Kaempferol activated the transcriptional activity of pERE-Luc (3.98 ± 0.31 folds at 50 μM) and induced estrogen receptor α (ERα) phosphorylation in cultured rat osteoblasts, and this ER activation was correlated with induction and associated with osteoblast differentiation biomarkers, including alkaline phosphatase activity and transcription of osteoblastic genes, e.g ., type I collagen, osteonectin, osteocalcin, Runx2 and osterix. (biomedcentral.com)
  • Our results demonstrate that kaempferol significantly reduces cell viabilities of U-2 OS, HOB and 143B cells, especially U-2 OS cells in a dose-dependent manner, but exerts low cytotoxicity on human fetal osteoblast progenitor hFOB cells. (nih.gov)
  • Results indicated that the free radical scavenging capability and cytotoxicity of kaempferol 3- O- β-D-glucopyranoside were enhanced through acylation with selected hydroxycinnamoyl groups, whereas mono-acylation did not improve both activities. (springer.com)
  • Furthermore, kaempferol had significantly less cytotoxicity than 5-fluorouracil in normal human pancreatic ductal epithelial cells (P = 0.029). (greenmedinfo.com)
  • BACKGROUND: Kaempferol is one of the most important constituents in ginkgo flavonoids. (greenmedinfo.com)
  • Kaempferol has been reported to act as an antioxidant and anti-inflammatory agent by inhibiting nitric oxide synthase and COX enzymes. (unboundmedicine.com)
  • Kaempferol is believed to have anti-inflammatory activities. (biomedcentral.com)
  • Kaempferol attenuates the development of diabetic neuropathic pain in mice: Possible anti-inflammatory and anti-oxidant mecha-nisms. (ac.ir)
  • Kaempferol, a yellow-colored powder, is a flavonoid that can be found in various natural resources such as apples , onions , leeks , citrus fruits , grapes , red wines , and ginkgo biloba . (naturalpedia.com)
  • Two coumaroyl flavonol glycosides, isorhamnetin 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside], and kaempferol 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside]-7-O-beta-D-glucopyranoside, were isolated from the n-BuOH extract of Ginkgo biloba leaves. (chemfaces.com)
  • Dietary intake of kaempferol ameliorated hyperglycemia and improved insulin levels in middle-aged obese diabetic mice. (greenmedinfo.com)
  • Mouse macrophage inflammatory protein-2 production and CXCR2 expression were upregulated in OVA-challenged mice, which was attenuated by oral administration of ≥10 mg/kg kaempferol. (hindawi.com)
  • This study further explored the blockade of Tyk-STAT signaling by kaempferol in both LPS-stimulated BEAS-2B cells and OVA-challenged mice. (hindawi.com)
  • These results demonstrate that kaempferol alleviated airway inflammation through modulating Tyk2-STAT1/3 signaling responsive to IL-8 in endotoxin-exposed airway epithelium and in asthmatic mice. (hindawi.com)
  • Mice were fed with a diet supplemented for 14 days and during the behavioral test period with kaempferol or quercitrin (30 mg/kg/day). (semanticscholar.org)
  • Mice in the Kae groups received a kaempferol (10-mg/kg body weight) injection 12 h prior to (Group Kae PT) or 90 min after (Group Kae T) the initiation of hemorrhagic shock. (biomedcentral.com)
  • In Langendorff heart from Ang II infused mice , kaempferol preserved normal impulse formation at right atrium . (bvsalud.org)
  • The final optimized phospholipidcomplex also demonstrated a significant improvement in oral bioavailability demonstrated by improvementsto key pharmacokinetic parameters, compared to that of pure kaempferol. (sjfc.edu)
  • The results of the present study provided solid evidence that kaempferol is a safe and potential radiosensitizer. (spandidos-publications.com)
  • Based on these results, kaempferol provides a starting point for the development of novel anti-biofilm drugs, which may decrease the risk of bacterial drug resistance, to prevent S. aureus biofilm-related infections. (frontiersin.org)
  • The results suggested that orlistat bound to the catalytic site while kaempferol interacted with W294 on the protein lid. (mdpi.com)
  • Our results suggest that two flavonoids (kaempferol and quercitrin) isolated from the Opuntia ficus-indica var. (semanticscholar.org)
  • Our results showed that kaempferol stimulates osteogenic differentiation of cultured osteoblasts by acting through the estrogen receptor signaling. (biomedcentral.com)
  • Pretreatment with kaempferol significantly improved the recovery of LVDP and ±dp/dt max, as well as increased the levels of SOD and P-GSK-3β and GSH/GSSG ratio. (nih.gov)
  • Therefore, kaempferol may be a therapeutic agent targeting asthmatic diseases. (hindawi.com)
  • According to Dr. Li, studies in the Netherlands have shown that women who ate endive (a good source of kaempferol) had a 75% reduction in the risk of ovarian cancer. (adventuresofaglutenfreemom.com)
  • Consumed in broccoli, kaempferol has been linked to a decrease in ovarian cancer in post-menopausal women. (infobloom.com)
  • The effect of quercetin and kaempferol on cell cycle in HL-60 cells was detected by flow cytometry. (greenmedinfo.com)
  • Treatment with kaempferol inhibited the growth of A-549 cells through activation of apoptotic pathway. (spandidos-publications.com)
  • Among the nonionic polymeric nanoparticles, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) nanoparticles incorporating kaempferol led to significant reduction in cell viability of both cancerous and normal cells. (dovepress.com)
  • Poly(DL-lactic acid-co-glycolic acid) (PLGA) nanoparticles incorporating kaempferol resulted in enhanced reduction of cancer cell viability together with no significant reduction in cell viability of normal cells compared with kaempferol alone. (dovepress.com)
  • Therefore, both PEO-PPO-PEO and PLGA nanoparticle formulations were effective in reducing cancer cell viability, while PLGA nanoparticles incorporating kaempferol had selective toxicity against cancer cells and normal cells. (dovepress.com)
  • Compared with the quercetin alone group, the transport ratio decreased 11.6-fold (from 97.5 to 8.37) in the presence of kaempferol in MDCK/Bcrp1 cells, indicating that kaempferol is a Bcrp inhibitor. (nih.gov)
  • Moreover, in MDCK/Bcrp1 cells, the P(app, B-A) of kaempferol was much higher (17.7 ± 3.8 × 10(-6) cm/s) than the P(app, A-B) (0.279 ± 0.037 × 10(-6) cm/s), with a transport ratio of 63.4. (nih.gov)
  • In contrast, the transport ratio of kaempferol was only 0.68 in Bcrp1-negative MDCK/Mock cells. (nih.gov)
  • Cho HJ, Han J, Park Y. Kaempferol induces cell cycle arrest in HT-29 human colon cancer cells. (banglajol.info)
  • Cells were incubated with 100mM kaempferol for 1h at 378C and the glucuronides( K1 and K2)were measured by HPLC. (strath.ac.uk)
  • On the other hand, kaempferol is one of the polyphenolic flavonoids that could inhibit growth of human leukaemic cells [ 15 ], but also claimed to be able to protect some cancer cell lines [ 16 ]. (alliedacademies.org)
  • Kaempferol also appears to make cancer cells more sensitive to anti-cancer agents, including chemotherapy drugs. (infobloom.com)
  • A study carried out by Blanco and colleagues [19] has shown that serum derived Kaempferol from individuals with SLE has the ability to induce the differentiation of monocytes into dendritic cells (DCs). (chenglilab.org)
  • Additionally, kaempferol exhibited a strong inhibitory effect on bladder cancer cells and high safety on normal bladder cells. (greenmedinfo.com)
  • Kaempferol treatment also significantly reduced 3H-thymidine incorporation in both MIA PaCa-2 and Panc-1 cells. (greenmedinfo.com)
  • In both MIA PaCa-2 and Panc-1 cells, apoptotic cell population was increased when treated with kaempferol in a concentration-dependent manner. (greenmedinfo.com)
  • Kaempferol is a strong antioxidant and helps to prevent oxidative damage of our cells, lipids and DNA. (sxgreenfine.com)
  • A new UHPLC-DAD-MS method based on a Core-Shell particles column was developed to realize the rapid separation of saffron stigma metabolites (Crocus sativus L.). A single separation of 35 compounds included cis and trans-crocetin esters (crocins), cis-crocetin, trans-crocetin, kaempferol derivatives, safranal, and picrocrocin from pure saffron stigmas. (usda.gov)
  • Kaempferol derivatives with rhamnose residue also seem to be quite effective. (unifi.it)
  • All oils inhibited the transport and conjugation of galangin, the most hydrophobic flavonol, whereas they increased the sulphation, and to some extent glucuronidation, of quercetin and kaempferol. (rsc.org)
  • The aim of the present study was to investigate a cytotoxic oxidative cell stress related and the antioxidant profile of kaempferol, quercetin, and isoquercitrin. (scielo.br)