Receptors, Adrenergic, beta
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
Receptors, Adrenergic, beta-2
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.
Receptors, Adrenergic, beta-1
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Cyclic AMP-Dependent Protein Kinases
8-Bromo Cyclic Adenosine Monophosphate
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
GTP-Binding Protein alpha Subunits, Gs
Dose-Response Relationship, Drug
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
Receptors, Adrenergic, beta-3
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Calcium Channels, L-Type
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Rats, Inbred Strains
Proline-Rich Protein Domains
Protein domains that are enriched in PROLINE. The cyclical nature of proline causes the peptide bonds it forms to have a limited degree of conformational mobility. Therefore the presence of multiple prolines in close proximity to each other can convey a distinct conformational arrangement to a peptide chain.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Adrenergic beta-2 Receptor Antagonists
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
Adrenergic beta-1 Receptor Antagonists
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
GTP-Binding Protein alpha Subunits, Gi-Go
LIPOLYSIS of stored LIPIDS in the ADIPOSE TISSUE to release FREE FATTY ACIDS. Mobilization of stored lipids is under the regulation of lipolytic signals (CATECHOLAMINES) or anti-lipolytic signals (INSULIN) via their actions on the hormone-sensitive LIPASE. This concept does not include lipid transport.
One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)
Cyclic Nucleotide Phosphodiesterases, Type 3
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Receptor, Muscarinic M2
Salivary Proteins and Peptides
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Heart Conduction System
A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Virulence Factors, Bordetella
A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.
Automatic activity in depolarized guinea pig ventricular myocardium. Characteristics and mechanisms. (1/5295)Membrane potential was changed uniformly in segments, 0.7-1.0 mm long, of guinea pig papillary muscles excised from the right ventricle by using extracellular polarizing current pulses applied across two electrically insulated cf preparations superfused with Tyrode's solution at maximum diastolic membrane potentials ranging from-35.2+/-7.5 (threshold) to +4.0+/-9.2 mV. The average maximum dV/dt of RAD ranged from 17.1 to 18.0 V/sec within a membrane potential range of -40 to +20 mV. Raising extracellular Ca2+ concentration [Ca2+]0 from 1.8 to 6.8 mM, or application of isoproterenol (10(-6)g/ml) enhanced the rate of RAD, but lowering [Ca2+]0 to 0.4 mM or exposure to MnCl2 (6 mM) abolished RAD. RAD were enhanced by lowering extracellular K+ concentration [K+]0 from 5.4 to 1.5 mM. RAD were suppressed in 40% of fibers by raising [K+]0 to 15.4 mM, and in all fibers by raising [K+]0 to 40.4 mM. This suppression was due to increased [K+]0 and not to K-induced depolarization because it persisted when membrane potential was held by means of a conditioning hyperpolarizing puled gradually after maximum repolarization. These observations suggest that the development of RAD in depolarized myocardium is associated with a time-dependent decrease in outward current (probably K current) and with increase in the background inward current, presumably flowing through the slow cha-nel carrying Ca or Na ions, or both. (+info)
Evaluation of the force-frequency relationship as a descriptor of the inotropic state of canine left ventricular myocardium. (2/5295)The short-term force-frequency characteristics of canine left ventricular myocardium were examined in both isolated and intact preparations by briefly pertubing the frequency of contraction with early extrasystoles. The maximum rate of rise of isometric tension (Fmas) of the isolated trabeculae carneae was potentiated by the introduction of extrasystoles. The ratio of Fmas of potentiated to control beats (force-frequency ratio) was not altered significantly by a change in muscle length. However, exposure of the trabeculae to isoproterenol (10(-7)M) significantly changed the force-frequency ratio obtained in response to a constant frequency perturbation. Similar experiments were performed on chronically instrumented conscious dogs. Left ventricular minor axis diameter was measured with implanted pulse-transit ultrasonic dimension transducers, and intracavitary pressure was measured with a high fidelity micromanometer. Atrial pacing was performed so that the end-diastolic diameters of the beats preceding and following the extrasystole could be made identical. Large increases in the maximum rate of rise of pressure (Pmas) were seen in the contraction after the extrasystole. The ratio of Pmax of the potentiated beat to that of the control beat was not changed by a 9% increase in the end-diastolic diameter, produced by saline infusion. Conversely, isoproterenol significantly altered this relationship in the same manner as in the isolated muscle. Thus, either in vitro or in situ, left ventricular myocardium exhibits large functional changes in response to brief perturbations in rate. The isoproterenol and length data indicate that the force-frequency ratio reflects frequency-dependent changes in the inotropic state, independent of changes in length. (+info)
AV reentrant and idiopathic ventricular double tachycardias: complicated interactions between two tachycardias. (3/5295)An electrophysiological study was performed in a 61 year old man with Wolff- Parkinson-White (WPW) syndrome. At baseline, neither ventricular nor supraventricular tachycardias could be induced. During isoprenaline infusion, ventricular tachycardia originating from the right ventricular outflow tract (RVOT) with a cycle length of 280 ms was induced and subsequently atrioventricular reentrant tachycardia (AVRT) with a cycle length of 300 ms using an accessory pathway in the left free wall appeared. During these tachycardias, AVRT was entrained by ventricular tachycardia. The earliest ventricular activation site during the ventricular tachycardia was determined to be the RVOT site and a radiofrequency current at 30 W successfully ablated the ventricular tachycardia at this site. The left free wall accessory pathway was also successfully ablated during right ventricular pacing. The coexistence of WPW syndrome and cathecolamine sensitive ventricular tachycardia originating from the RVOT has rarely been reported. Furthermore, the tachycardias were triggered by previous tachycardias. (+info)
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. (4/5295)The ability of the M2 muscarinic receptor to mediate an inhibition of the relaxant effects of forskolin and isoproterenol was investigated in guinea pig ileum and trachea. In some experiments, trachea was first treated with 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) mustard to inactivate M3 receptors. The contractile response to oxotremorine-M was measured subsequently in the presence of both histamine (10 microM) and isoproterenol (10 nM). Under these conditions, [[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5, 11-dihydro-6H-pyrido[2,3b]-[1,4]benzodiazepine-6-one (AF-DX 116) antagonized the contractile response to oxotremorine-M in a manner consistent with an M3 mechanism. However, when the same experiment was repeated using forskolin (4 microM) instead of isoproterenol, the response to oxotremorine-M exhibited greater potency and was antagonized by AF-DX 116 in a manner consistent with an M2 mechanism. We also measured the effects of pertussis toxin treatment on the ability of isoproterenol to inhibit the contraction elicited by a single concentration of either histamine (0.3 microM) or oxotremorine-M (40 nM) in both the ileum and trachea. Pertussis toxin treatment had no significant effect on the potency of isoproterenol for inhibiting histamine-induced contractions in the ileum and trachea. In contrast, pertussis toxin treatment enhanced the relaxant potency of isoproterenol against oxotremorine-M-induced contractions in the ileum but not in the trachea. Also, pertussis toxin treatment enhanced the relaxant potency of forskolin against oxotremorine-M-induced contractions in the ileum and trachea. We investigated the relaxant potency of isoproterenol when very low, equi-effective (i.e., 20-34% of maximal response) concentrations of either histamine or oxotremorine-M were used to elicit contraction. Under these conditions, isoproterenol exhibited greater relaxant potency against histamine in the ileum but exhibited similar relaxant potencies against histamine and oxotremorine-M in the trachea. Following 4-DAMP mustard treatment, a low concentration of oxotremorine-M (10 nM) had no contractile effect in either the ileum or trachea. Nevertheless, in 4-DAMP mustard-treated tissue, oxotremorine-M (10 nM) reduced the relaxant potency of isoproterenol against histamine-induced contractions in the ileum, but not in the trachea. We conclude that in the trachea the M2 receptor mediates an inhibition of the relaxant effects of forskolin, but not isoproterenol, and the decreased relaxant potency of isoproterenol against contractions elicited by a muscarinic agonist relative to histamine is not due to activation of M2 receptors but rather to the greater contractile stimulus mediated by the M3 receptor compared with the H1 histamine receptor. (+info)
Kinetic analysis of drug-receptor interactions of long-acting beta2 sympathomimetics in isolated receptor membranes: evidence against prolonged effects of salmeterol and formoterol on receptor-coupled adenylyl cyclase. (5/5295)The long-acting beta2 sympathomimetics salmeterol and formoterol have been presumed to exert their prolonged action either by binding to an accessory binding site ("exo-site") near the beta2 adrenoceptor or by their high affinity for beta2 adrenoceptors and correspondingly slow dissociation. Whereas most studies with salmeterol had been done in intact tissues, which have slow diffusion and compartmentation of drugs in lipophilic phases, that restrict drug access to the receptor biophase, we used purified receptor membranes from rat lung and disaggregated calf tracheal myocytes as model systems. Binding experiments were designed to measure the slow dissociation of agonists by means of delayed association of (-)-[125I]iodopindolol. Rat lung membranes were pretreated with high concentrations of agonists (salmeterol, formoterol, isoprenaline) before dissociation was induced by 50-fold dilution. Half-times of association of (-)-[125I]iodopindolol remained unchanged compared with untreated controls, indicating that dissociation of agonists occurred in less than 2 min. Adenylyl cyclase experiments were designed to determine the on and off kinetics of agonists to beta2 adrenoceptors by measuring the rate of receptor-induced cyclic AMP (cAMP) formation. Experiments were performed in tracheal membranes characterized by high Vmax values of cAMP formation. Adenylyl cyclase activation occurred simultaneously with the addition of the agonist, continued linearly with time for 60 min, and ceased immediately after the antagonist was added. Similarly, when receptor membranes were preincubated in a small volume with high salmeterol concentrations, there was a linear increase in cAMP formation, which was immediately interrupted by a 100-fold dilution of the reaction mixture. This militates against the exo-site hypothesis. On the other hand, dissociation by dilution was much less when membranes were preincubated with a large volume of salmeterol at the same concentration, indicating that physicochemical effects, and not exo-site binding, underlie its prolonged mode of action. (+info)
Angiotensin receptor subtype 1 mediates angiotensin II enhancement of isoproterenol-induced cyclic AMP production in preglomerular microvascular smooth muscle cells. (6/5295)In a previous study, we found that angiotensin (Ang) II enhances beta-adrenoceptor-induced cAMP production in cultured preglomerular microvascular smooth muscle cells (PMVSMCs) obtained from spontaneously hypertensive rats. The purpose of the present investigation was to identify the Ang receptor subtypes that mediate this effect. In our first study, we compared the ability of Ang II, Ang III, Ang (3-8), and Ang (1-7) to increase cAMP production in isoproterenol (1 microM)-treated PMVSMCs. Each peptide was tested at 0.1, 1, 10, 100, and 1000 nM. Both Ang II and Ang III increased intracellular (EC50s, 1 and 11 nM, respectively) and extracellular (EC50s, 2 and 14 nM, respectively) cAMP levels in a concentration-dependent fashion. In contrast, Ang (3-8) and Ang (1-7) did not enhance either intracellular or extracellular cAMP levels at any concentration tested. In our second study, we examined the ability of L 158809 [a selective Ang receptor subtype 1 (AT1) receptor antagonist] to inhibit Ang II (100 nM) and Ang III (100 nM) enhancement of isoproterenol (1 microM)-induced cAMP production in PMVSMCs. L 158809 (10 nM) abolished or nearly abolished (p <.001) Ang II and Ang III enhancement of isoproterenol-induced intracellular and extracellular cAMP levels. In contrast, PD 123319 (300 nM; a selective AT2 receptor antagonist) did not significantly alter Ang II enhancement of isoproterenol-induced intracellular or extracellular cAMP levels. We conclude that AT1 receptors, but not AT2, Ang (3-8), nor Ang (1-7) receptors mediate Ang II and Ang III enhancement of beta-adrenoceptor-induced cAMP production in cultured PMVSMCs. (+info)
Evidence for beta3-adrenoceptor subtypes in relaxation of the human urinary bladder detrusor: analysis by molecular biological and pharmacological methods. (7/5295)The purpose of the present study was to confirm the presence of beta3-adrenoceptor subtype in the relaxation of human urinary bladder detrusor tissue by reverse transcription-polymerase chain reaction (PCR); direct sequencing of the PCR product, in situ hybridization; and isometric contraction. Using reverse transcription-PCR, the mRNAs of three receptor subtypes (beta1, beta2, and beta3) were expressed in the human urinary bladder detrusor tissue. Direct sequencing of the PCR product of the above beta3-adrenoceptor revealed no mutation in the amplified regions. In situ hybridization with digoxygenin-labeled oligonucleotide probe revealed the presence of the mRNA of beta3-adrenoceptor subtype in the smooth muscle of the urinary bladder. The relaxant effects of isoproterenol (a nonselective beta-adrenoceptor agonist); ZD7114, BRL37344, and CGP12177A (putative selective beta3-adrenoceptor agonists); and SR59230A (a putative selective beta3-adrenoceptor antagonist) were tested using an isometric contraction technique. Isoproterenol in either the presence or absence of both atenolol (a beta1-adrenoceptor-selective antagonist) and butoxamine (a beta2-adrenoceptor-selective antagonist) revealed a relaxant effect on the carbachol-induced contraction of the human urinary bladder detrusor. Both BRL37344 and CGP12177A also revealed relaxant effects on the human urinary bladder detrusor, but ZD7114 did not elicit any relaxation. These results suggest that beta3-adrenoceptor may have some role in urine storage in the human urinary bladder. (+info)
A possible mode of cardiovascular actions of dopamine in dogs. (8/5295)A possible mode of cardiovascular actions of dopamine was studied using ephedrine. In the dog pretreated with repeated administrations of ephedrine (total dose, 40 or 80 mg/kg, i.v.) or with combined administrations of ephedrine (total dose, 90 mg/kg, s.c. and i.v.) and reserpine (2 mg/kg, s.c., 24 hr previously), pressor responses to dopamine were eliminated and reversed to depressor responses whereas depressor responses to dopamine were potentiated. Positive chronotropic effects of dopamine were almost eliminated. Pressor and positive chronotropic effects of tyramine were almost abolished. Sympathomimetic effect of noradrenaline and adrenaline were potentiated while those of isoprenaline were inhibited. In the heart-lung preparation of ephedrine-treated dogs (total dose, 40 mg/kg, i.v.), cardiac stimulating effects of dopamine and tyramine were strongly depressed, and those of noradrenaline, adrenaline and isoprenaline were reduced to some extent. In the open-chest dogs, after pretreatment of cocaine (4 mg/kg, i.v.), pressor, positive inotropic and chronotropic effects of noradrenaline were potentiated, whilst those of tyramine were inhibited. Those of dopamine were not visibly altered, but depressor, negative chronotropic and inotropic effects of dopamine appeared at small doses. In the ephedrine-pretreated dogs, these sympathomimetic effects of dopamine and tyramine after cocaine were strongly depressed and those of noradrenaline were inhibited to a certain degree. The results obtained with ephedrine suggest that dopamine differs from other catecholamines and tyramine in the mode of cardiovascular actions. (+info)
Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. -...
Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. Isoproterenol (5 mg.kg(-1).day(-1)) was infused for 7 days in male Wistar rats (n = 22). In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, respectively, following isoproterenol infusion. Cardiac function at the base of the left ventricle was normal, but apical ejection fraction decreased from 90% to 31% and apical free wall thickening decreased by 94%, accompanied by increased fibrosis and inflammation. Myocardial palmitate oxidation rates were 25% lower, and citrate synthase and medium chain acyl-coenzyme A dehydrogenase activities were reduced by 25% and 29%, respectively, following isoproterenol infusion. Fatty acid transporter protein levels were 11
Import Data And Price Of L Isoproterenol | www.eximpulse.com
Import Data And Price Of L Isoproterenol , www.eximpulse.com Eximpulse Services will provide you the latest and relevant market intelligence reports of L Isoproterenol Import Data. You can find live data of maximum number of ports of India which is based on updated shipment data of Indian Customs. Only previous two days data will be seen on website. You can use this L Isoproterenol import data for multiple kinds of analysis; lets say Import price, Quantity, market scenarios, Price trends, Duty optimization and many more. You can go through some of the sample shipment records for L Isoproterenol import data mentioned above. Here on Eximpulse Services you will get all kind of free sample as well as detailed reports of Export/ Import data as per your requirement. To get in touch for any kind of enquiry related to free sample or detailed report contact on +91-120-408-4957, +91-120-408-4958,+91-120-428-4019.. Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of ...
Acute and chronic intrarenal alpha- and beta- adrenergic receptor stimulation of renin release in the conscious dog. |...
The effect of continuous intrarenal infusion of norepinephrine, isoproterenol, and methoxamine on renin release was studied in the uninephrectomized conscious dog. Chronic intrarenal infusion of norepinephrine produced a biphasic curve of plasma renin activity (PRA) and a sustained 25 mm Hg increase in mean arterial pressure (MAP). The initial increase in PRA peaked at 3 hours, after which PRA returned to control levels. Alpha- or beta-adrenergic antagonists did not attenuate the initial rise in PRA. The PRA increased again after 48 hours of chronic intrarenal norepinephrine infusion and remained elevated thereafter. The second rise in PRA was increased by 30% with alpha-adrenergic blockade. Chronic intrarenal isoproterenol administration produced a similar increase in PRA, which peaked at 3-5 hours and then returned to control levels. In contrast to norepinephrine, chronic isoproterenol administration did not result in a second increase in PRA. At the end of the chronic isoproterenol infusion ...
Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates | SRI International
Abstract. To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment. Three serum proteins--serum amyloid A (SAA), α-1-acid glycoprotein (A1AG), and apolipoprotein A-1 (Apo A1)--were consistently identified as changed and remained altered 72 h post dose in all three species post ISO treatment, indicating the potential of including these proteins in preclinical or clinical evaluation of drug-induced cardiac injury. Furthermore, proteomic analysis of heart tissue proteins following ISO treatment demonstrated detrimental effects on calcium signaling and energy generation in cardiac myocytes. It is worth noting that cardiac troponins were not identified in serum but were identified as altered in heart tissue lysate along with other cardiac-specific proteins. This strategy for cardiac biomarker discovery by proteomic screening of heart tissue proteins, ...
Isoproterenol Isoproterenol Systematic (IUPAC) name 4-[1-hydroxy-2-(1-methylethylamino) ethyl] benzene-1,2-diol Identifiers CAS number 7683-59-2 ATC code
CONICET | Buscador de Institutos y Recursos Humanos
OBJECTIVE: Myocardial damage induced by isoproterenol is believed to be secondary to increased oxygen demands on the heart. Our objective was to test an additional primary action of isoproterenol on tissue and mitochondrial oxidative metabolism and to compare these effects with the effects of other adrenergic agents in the presence of adrenergic inhibitors. DESIGN: Prospective, dose-response study. SETTING: Research laboratory at a university hospital. SUBJECTS: Fifty Sprague-Dawley female rats (200 to 350 g), slightly anesthetized with ether and divided into several groups. INTERVENTIONS: In 26 rats, the heart was removed, cut into fine slices (0.5-mm thickness), and placed in an ice-cold buffer. In 22 animals, the hearts were perfused in the Langendorff manner and chopped and processed for mitochondrial studies. MEASUREMENTS AND MAIN RESULTS: We determined the following: a) the direct in vitro effects of isoproterenol and related catecholamines on normal oxygen uptake using myocardial ...
Effect of chrysin on MAPKs protein expressions followin | Open-i
Effect of chrysin on MAPKs protein expressions following isoproterenol-induced myocardial injury. (a) ERK½ and P-ERK½; (b) JNK and P-JNK; (c) p38 and P-p38 an
EFFECTS OF VASOPRESSIN AND ISOPRENALINE INFUSIONS ON THE DISTRIBUTION OF BLOOD FLOW IN THE INTESTINE; CRITERIA FOR THE VALIDITY OF MICROSPHERE STUDIES = EFFETS DES PERFUSIONS DE VASOPRESSINE ET DISOPRENALINE SUR LA REPARTITION DU FLUX SANGUIN DANS LINTESTIN; CRITERE DE VALIDITE POUR LETUDE PAR MICROSPHERESGREENWAY CV ...
Isoproterenol | GreenMedInfo | Toxic Ingredient | Natural Medicine
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BS EN ISO 2580-2:2003
ISO 62:1999, ISO 75-2:1993, ISO 178:1993, ISO 179:1993, ISO 180:1993, ISO 293:1986, ISO 294-1:1996, ISO 306:1994, ISO 527-2:1993, ISO 527-4:1997, ISO 899-1:1993, ISO 1133:1997, ISO 1183:1987, ISO 1656:1996, ISO 2561:1974, ISO 2580-1, ISO 2818:1994, ISO 3167:1993, ISO 4581:1994, ISO 4589:1984, ISO 8256:1990, ISO 10350:1993, ISO 11357-2:1999, IEC 60093:1980, IEC 60112:1979, IEC 60243-1:1998, IEC 60250:1969, IEC 60296:1982, IEC 60695-11-10:1999, EN ISO 62:1999, EN ISO 75-2:1996, EN ISO 293:2003, EN ISO 294-1:1998, EN ISO 306:1996, EN ISO 527-2:1996, EN ISO 527-4:1997, EN ISO 1133:1999, EN ISO 2818:1996, EN ISO 8256:1996 ...
EN482, EN45544-2:1999, EN45544-3:1999, EN50270, EN60073, EN60068-2-6, ISO 3534-1, ISO 6141, ISO 6142, ISO 6143, ISO 6144, ISO 6145-1, ISO 6145-3, ISO 6145-4, ISO 6145-6, ISO 6147, ISO 6879:1995, ISO 7504 ...
ISO 3166-2:BR - Вікіпедія
ISO 3166-2:BR - стандарт ISO, який визначає геокоди для Бразилії. Він є частиною стандарту ISO 3166-2. Перша частина коду - код ISO 3166 для Бразилії (BR), друга частина - двоцифровий код регіону. ...
Iso Sunibutol in Malayalam ഉപയോഗങ്ങൾ, ഡോസേജ്, പാർശ്വഫലങ്ങൾ, പ്രയോജനങ്ങൾ, പ്രതിപ്രവർത്തനങ്ങൾ, മുന്നറിയിപ്പ് - Iso ...
Iso Sunibutol in Malayalam - ന്റെ ഉപയോഗങ്ങൾ, ഡോസേജ്, പാർശ്വഫലങ്ങൾ, പ്രയോജനങ്ങൾ, പ്രതിപ്രവർത്തനങ്ങൾ, മുന്നറിയിപ്പ് എന്നിവ കണ്ടെത്തുക - Iso Sunibutol upayogangal, dossge, parswafalangal, prayojanangal, prathipravarthanangal, munnariyippu
What is ISO 9001 and should i care? SAFER, SMARTER, GREENER - PDF
What is ISO 9001 and should i care? SAFER, SMARTER, GREENER 02 THE ROLE OF STANDARDS What is ISO 9001 and should I care? The Role of Standards The objective of any standard, whether it relates to the manufacture
Possible roles of nitric oxide and vasoactive intestinal polypeptide on relaxation induced by isoprenaline in isolated muscle...
The possible role of nitric oxide (NO) and vasoactive intestinal polypeptide on isoprenaline-induced relaxation of the mouse longitudinal gastric fundal strips precontracted with 5.4 X 10(-7)M carbachol was investigated. Isoprenaline (5 X 10(-7)M, 10(-6)M and 5 X 10(-6)M) produced a concentration-dependent relaxations. N-G-nitro L-arginine (10(-4)M) partly inhibited isoprenaline-induced relaxation. The inhibitory action of N-G-nitro L-arginine was reversed by 4 X 10(-4)M L-arginine but not by 4 X 10(-4)M D-arginine. N-G-nitro L-arginine (10(-4)M) did not affect the relaxation caused by sodium nitroprusside (10(-6)M). Vasoactive intestinal polypeptide antibody 7913 (1:160 dilution) partly inhibited isoprenaline-induced relaxation, This inhibition was greater on the response to the higher isoprenaline concentration (5 X 10(-6)M) than to the lower concentration (10(-6)M). The combination of vasoactive intestinal polypeptide antibody and N-G-nitro L-arginine significantly enhanced the inhibition on ...
Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of...
TY - JOUR. T1 - Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.. AU - Emala, C.. AU - Black, C.. AU - Curry, C.. AU - Levine, M. A.. AU - Hirshman, C. A.. PY - 1993/6. Y1 - 1993/6. N2 - Previous studies in human asthmatics have suggested a defect in the beta-adrenergic pathway leading to cyclic adenosine monophosphate (cAMP) generation. Although these studies have suggested normal or increased numbers of beta-adrenergic receptors, limitations in the quantity of tissue available have not allowed further delineation of the biochemical or molecular mechanisms of human asthma. The basenji-greyhound (BG) dog model of nonspecific airway hyperreactivity displays similarities to human asthma, and altered functional response to beta-adrenergic agonists has been previously shown in airway tissue from this model. We have now correlated this functional impairment in beta-adrenergic response with a ...
Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus<...
TY - JOUR. T1 - Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus. AU - Paietta, Elisabeth M.. AU - Schwarzmeier, J. D.. AU - Simbruner, G.. AU - Latzka, U.. AU - Lubec, G.. PY - 1981. Y1 - 1981. N2 - Using the adenylate cyclase assay after Ross the authors examined hormone sensitivity of isolated glomerular cells. cAMP production was increased 1.3-1.6-fold by stimulation with isoproterenol, 1.5-1.8 times by prostaglandin E 1 and 1.4-1.5 times by histamine. The isoproterenol reaction could be completely inhibited by propranolol, the histamine effect was abolished by the H2-blocking agent cimetidine. As a control the authors applied sodium fluoride, which directly activates the catalytic adenylate cyclase unit, increasing the activity 1.8-2.7 times (depending on the method of homogenization). These findings could reflect some physiological or pathophysiological implications, which are discussed.. AB - Using the adenylate cyclase ...
Comparison of the cardiocirculatory effects of exercise and isoproterenol in children with pulmonary or aortic valve stenosis. ...
Isoproterenol infusion during cardiac catheterization as a simulator of exercise was evaluated with hemodynamic studies in children with pulmonary (15) or aortic (8) valve stenosis. Cardiac function was monitored during rest, mild exercise and isoproterenol infusion. Similar heart rates were maintained in both procedures. Peak pulmonary and aortic valve gradients as well as right and left ventricular dp/dt/p were significantly higher and cardiac index significantly lower with isoproterenol as compared to exercise. Isoproterenol induced a significantly greater decrease in systemic vascular resistance, and systemic blood pressure than did exercise. Left ventricular systolic pressure rose to similar levels and this resulted in substantially higher peak aortic gradients with isoproterenol. A consistent correlation was observed for peak valvular gradients measured during exercise and isoproterenol in both groups of patients. Accordingly, regression equations were obtained allowing reasonably accurate ...
Temporal effects of cytokines on neonatal cardiac myocyte Ca2+ transients and adenylate cyclase activity., Department of...
This study investigates the hypothesis that inflammatory cytokines, interleukin (IL)-1alpha IL-1beta, and tumor necrosis factor (TNF), influence cardiac function by affecting calcium homeostasis and that this effect is mediated by the beta-adrenergic-adenylate cyclase system. After 4 days in culture, neonatal rat ventricular myocytes were treated with cytokines (10 ng/ml) for short (2 h) or longer (18 h) times. Myocyte calcium, contractility, and adenylate cyclase were measured under each condition. Anticipated stepwise increases in adenylate cyclase and intracellular calcium were found in controls (non-cytokine-treated) with 10(-7) M isoproterenol, 10(-7) M isoproterenol + 0.1 mM guanosine triphosphate, and 10(-9) M forskolin. Cells in the presence of cytokine for 2 h show increased basal calcium levels but no changes in adenylate cyclase activities, and isoproterenol fails to elevate adenylate cyclase levels or affect contractile shortening. After long-term treatment with IL-1beta or TNF, but ...
Pfizer Información Médica - República de Guatemala (Republic of Guatemala)
Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine hydrochloride produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.. In patients with depressed cardiac function, both dobutamine hydrochloride and isoproterenol increase the cardiac output to a similar degree. In the case of dobutamine hydrochloride, this increase is usually not accompanied by marked increases in heart rate (although tachycardia is occasionally observed), and the cardiac stroke volume is usually increased. In contrast, isoproterenol increases the cardiac index primarily by increasing the heart rate while stroke volume changes little or ...
Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular...
Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells.
Skin fibroblast beta-adrenergic receptor function in manie-depressive illness<...
TY - JOUR. T1 - Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. AU - Berrettini, Wade H.. AU - Bardakjian, Josiane. AU - Cappellari, Charles B.. AU - Barnett, Arthur L.. AU - Albright, Allen. AU - Nurnberger, John I.. AU - Gershon, Elliot S.. PY - 1987/12. Y1 - 1987/12. N2 - Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.. AB - Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine ...
Isoproterenol and Electrocardiographic Findings | Annals of Internal Medicine | American College of Physicians
To the editor: Drs. Berger and Winsor comment in their recent letter (1) on Shims and Williams paper evaluating the safety of isoproterenol (2). They report their own findings (3, 4) that isoproterenol in similar therapeutic doses resulted in ischemic ECG changes.. Shim and Williams administered overdosages of isoproterenol from pressurized aerosol containers to asthmatic patients without heart disease. Puffs of 100 µg were given in repeated doses of either two puffs every 5 min or five to 10 puffs every 20 min. There were no arrhythmias or changes in ST segments. The authors concluded that the drug is safe ...
Dual hit rat models of diabetic cardiomyopathy and nephropathy: pancreatectomy combined with isoprenaline treatment or...
Background Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. We hypothesized that experimental ...
Demonstration of beta 2 mediated positive chronotropic action of isoproterenol in anesthetized dogs comparison with selective...
Yabana H.; Sugimoto T.; Nagao T., 1990: Demonstration of beta 2 mediated positive chronotropic action of isoproterenol in anesthetized dogs comparison with selective beta 1 agonist t 0509
Studies were directed to measurement of hyperlactic acidemia and hyperglycemia induced by various catecholamines in anesthetized rats and conscious dogs. A family of compounds structurally related to the beta adrenergic blocking agent sotalol (MJ 1999) was investigated for potency with respect to inhibition of the aforementioned metabolic responses. Data were correlated with attenuation of isoproterenol-induced relaxation of isolated guinea-pig tracheal smooth muscle. Increasing the alkyl chain length of the p-alkylsulfonamido moiety on the benzene ring reduced beta adrenergic blocking activity, as did increasing the size of the N-alkyl group on the amino nitrogen up to n-heptyl. Branched N-alkyl groups (e.g., sec.-and tert.-butyl) increased potency. Alpha,. alkyl substitution of the ethanol moiety variably enhanced or lessened beta blocking activity. For the series of compounds, in general, diminution of epinephrine-induced metabolic responses in vivo correlated well with antagonism of ...
The purpose of this study was to investigate the mechanism of histamines H1-receptor-mediated positive inotropic effect, a response which is not associated with an increase in cyclic AMP levels. We found that the concentration-response curve for the positive inotropic effect of histamine on cavian left atrium was similar to that of the alpha-1 agonist phenylephrine, in terms of slope and maximum response. Additionally, both agents slightly prolonged time-to-peak tension and relaxation times. In contrast, the concentration-response relationship for the beta-agonist isoproterenol, whose positive inotropic effect is mediated by an increase in cyclic AMP, had a steeper slope and a much greater maximum. Furthermore, isoproterenol abbreviated time-to-peak tension and relaxation times. As reported previously for alpha-1 agonists, the development of the contractile response to a submaximal histamine concentration (10 microM) coincided with a rapid increase in left atrial tissue levels of inositol ...
Search Results | joe
Postprandial release of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) from L cells results from both nutrient transit in the ileal lumen and neural drive of endocrine cells. The adrenosympathetic system and its effectors have been shown to induce secretion of L cells in vivo or in vitro. Because these transmitters act through three receptors, beta, alpha1, alpha2, coupled to different intracellular pathways, we evaluated the responses of L cells to specific agonists, using the model of isolated vascularly perfused rat ileum. General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin. Blockade of alpha2-receptors with idazoxan (10(-8) M) did not alter epinephrine-induced peptide secretion. The beta-adrenergic agonist isoproterenol (10(-6) M) infused for 30 min ...
December 2017 - When do the MUCOMYST W/ ISOPROTERENOL patents expire, and when will generic MUCOMYST W/ ISOPROTERENOL enter the...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Effects Of β-adrenergic Stimulation On The Ventricular Action Potential: A Simulation Study
Cathecholamines increase heart rate and contraction force. This effect is mainly mediated by their interaction with the β-adrenergic receptor...
AID 218832 - Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of...
BioAssay record AID 218832 submitted by ChEMBL: Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs.
Isoprenaline - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Isoprenaline - Get up-to-date information on Isoprenaline side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Isoprenaline
beta-adrenergic receptor activity QuickView - Correlation Engine
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a…
Sensitivity and Resistance of the Myocardium to the Toxicity of Isoproterenol in Rats | Springer for Research & Development
The toxicity of a chemical is not a colligative property of a substance; it is a function of the susceptibility of the organism upon which the chemical acts. The susceptibility is determined by the...
BS EN 45544-4:2000
EN 482:1994, EN 45544-1, EN 45544-2, EN 45544-3, EN 689:1995, EN 50014, EN 50015, EN 50016, EN 50017, EN 50018, EN 50019, EN 50020, EN 50028, EN 50039, EN 50054, EN 50073, EN 50270, EN 60079-10:1996, IEC 60079-10:1995, ISO 3534-1, ISO 6141:1984, ISO 6142:1981, ISO 6143:1981, ISO 6144:1981, ISO 6145-1:1986, ISO 6145-3:1986, ISO 6145-4:1986, ISO 6145-6:1986, ISO 6147:1979, ISO 6349:1995, ISO 6879:1996, ISO 7504:1984 ...
Regulation of cardiac beta-adrenergic receptors by captopril. Implications for congestive heart failure. | Circulation
The interaction of the renin-angiotensin system and the sympathetic nervous system in patients with congestive heart failure is not well understood. We tested the hypothesis that angiotensin-converting enzyme inhibitors can resensitize the beta-adrenergic receptor system. Guinea pigs were given captopril, isoproterenol, or both for 2 weeks. At death, cardiac sarcolemmal and light vesicle fractions and intact mononuclear leukocytes were prepared. Captopril treatment led to an up-regulation of cardiac beta 1- but not mononuclear leukocyte beta 2-adrenergic receptors and an increase in isoproterenol-stimulated adenylate cyclase activity in the heart. Animals treated with isoproterenol developed cardiac hypertrophy, had increased plasma norepinephrine levels, and had a decreased number and responsiveness of both cardiac and mononuclear leukocyte beta-adrenergic receptors. Concomitant treatment with captopril attenuated alterations of heart weight, plasma norepinephrine levels, and cardiac ...
The effects of the simple bioactive lipid mediator lysophosphatidic acid (LPA) on cAMP accumulation were investigated in cultured human airway smooth muscle cells (ASMC). Pretreatment of cells with LPA induced an increase in subsequent stimulation of cAMP accumulation by forskolin and by isoproterenol. When included during the assay of cAMP accumulation rather than as a pretreatment, LPA inhibited forskolin stimulation but enhanced isoproterenol stimulation. Both effects of LPA on forskolin stimulation were completely blocked by pertussis toxin treatment, whereas the effects on isoproterenol stimulation appeared relatively insensitive to pertussis toxin. The protein kinase C activator phorbol-12-myristate-13-acetate (PMA) sensitized forskolin stimulation to a similar extent as did LPA, and the combination of LPA plus PMA caused markedly more sensitization than either agent alone. In contrast, PMA inhibited isoproterenol stimulation and markedly decreased the sensitization induced by LPA. Serum ...
Frontiers | Toll-Like Receptor 4 Inhibition Improves Oxidative Stress and Mitochondrial Health in Isoproterenol-Induced Cardiac...
Background- Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important regulator of innate immunity, the precise pathway of TLR4 mediated cardiac complications is yet to be established. Therefore, the primary objective of the present study was to find the role of TLR4 in cardiac hypertrophy and the molecular mechanism thereof. Methods- Cardiac hypertrophy was induced with administration of isoproterenol (5mg/kg/day, sc). TLR4 receptor inhibitor RS-LPS (lipopolysaccharide from the photosynthetic bacterium Rhodobacter sphaeroides; 5 microgram/day) and agonist LPS (Lipopolysaccharide from Escherichia coli; 3.12 microgram/day) were administered through osmotic pump along with isoproterenol. Cardiac hypertrophy as well as oxidative stress and mitochondrial
Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol. | Circulation Research
The incorporation of 32Pi into phospholamban, troponin I, phosphatidylinositols, and inositol trisphosphates was studied in Langendorff-perfused guinea pig hearts stimulated with isoproterenol. Hearts were perfused with Krebs-Henseleit buffer containing [32P]Pk and freeze-clamped at different times during the positive inotropic response. Exposure of the hearts to 0.1 microM isoproterenol for up to 1 minute was associated with significant (up to threefold) increases in phospholamban and troponin I phosphorylation, but there was no significant increase in 32P incorporation into phospholipids. However, longer exposure (2 minutes or more) to isoproterenol was associated with increases in the degree of 32P labeling of phosphatidylinositols and phosphatidic acid. Examination of 32P labeling of inositol trisphosphates in the same hearts revealed that the radioactivity associated with these compounds decreased with time. The decreases were significant at times of exposure of 2 minutes or longer to ...
Isoproterenol reversal of antiarrhythmic effects in patients with inducible sustained ventricular tachyarrhythmias | JACC:...
Seventeen patients (16 men and I woman) were challenged with isoproterenol after their initially inducible sustained ventricular tachyarrhythmia (monomorphic tachycardia in 14 patients and fibrillation in 3) was completely suppressed by class I antiarrhythmic drugs. Coronary artery disease was documented in 11 patients, dilated cardiomyopathy in 2 and no structural heart disease in the remaining 4 patients. The initial presentation was aborted sudden cardiac death (five patients), syncope (eight patients) and symptomatic nonsustained ventricular tachycardia (four patients). The antiarrhythmic drug that rendered the initial ventricular tachyarrhythmias noninducible was class IA in 11 cases, class IC in 5 and combined class IA and IB in 1.. The original ventricular tachyarrhythmia became reinducible in 10 patients (group A) and remained noninducible in 7 patients (group B) after isoproterenol infusion at a rate necessary to achieve a 20% increase in heart rate. Despite the results of isoproterenol ...
Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial...
TY - JOUR. T1 - Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats. AU - Sangeetha, T.. AU - Quine, S. Darlin. PY - 2008/7/1. Y1 - 2008/7/1. N2 - The antihyperlipidemic, antilipoperoxidative and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats were reported previously. The present study was undertaken to evaluate the preventive role of SACS on some biochemical parameters, glycoproteins and hematology in experimentally induced myocardial infarction in rats. Myocardial infarction was induced in rats by subcutaneous injection of isoproterenol (ISO) (150 mg kg -1) at an interval of 24 h for 2 days. ISO-treated rats showed a significant increase in the levels of serum iron, uric acid and blood glucose, Na+ and Ca2+ in the heart and a significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K+ and ...
Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart - a...
The chronic administration of the β-adrenoreceptor agonist isoproterenol (IsoP) is used in animals to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines. Time-dependent changes in myocardial blood flow (MBF), morphological and functional parameters were assessed in rats in vivo using multimodal cardiac MRI. Energy metabolism, oxidative stress and the nitric oxide (NO) pathway were evaluated in isolated perfused rat hearts following 7 days of treatment. Male Wistar rats were infused for 7 days with IsoP or vehicle using osmotic pumps. Cine-MRI and arterial spin labeling were used to determine left ventricular morphology, function and MBF at days 1, 2 and 7 after pump implantation. Isolated hearts were then perfused, and high-energy phosphate compounds and intracellular pH were followed using ³¹P MRS with simultaneous measurement of contractile function. Total creatine and malondialdehyde (MDA) contents were measured by high
Alpha-1-adrenergic receptors in heart failure: The adaptive arm of the cardiac response to chronic catecholamine stimulation<...
TY - JOUR. T1 - Alpha-1-adrenergic receptors in heart failure. T2 - The adaptive arm of the cardiac response to chronic catecholamine stimulation. AU - Jensen, Brian C.. AU - OConnell, Timothy D.. AU - Simpson, Paul C.. PY - 2014/4. Y1 - 2014/4. N2 - Alpha-1-adrenergic receptors (ARs) are G protein-coupled receptors activated by catecholamines. The alpha-1A and alpha-1B subtypes are expressed in mouse and human myocardium, whereas the alpha-1D protein is found only in coronary arteries. There are far fewer alpha-1-ARs than beta-ARs in the nonfailing heart, but their abundance is maintained or increased in the setting of heart failure, which is characterized by pronounced chronic elevation of catecholamines and beta-AR dysfunction. Decades of evidence from gain and loss-of-function studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac alpha-1-ARs to include physiological hypertrophy, positive inotropy, ischemic preconditioning, and ...
Catecholamine-induced myocardial potassium uptake mediated by beta 1-adrenoceptors and adenylate cyclase activation in the pig....
The myocardial potassium uptake during intracoronary isoproterenol stimulation was characterized in 12 anesthetized pigs. The beta-receptor subtype specificity and the effect of adenylate cyclase activation were determined. Potassium concentrations were continuously recorded by PVC-valinomycin minielectrodes in the left atrial cavity and in coronary sinus blood diverted through a shunt to the right atrium. The difference in potassium concentration between the left atrial cavity and coronary sinus, and the accumulated myocardial potassium uptake were calculated after computerized data sampling. By intracoronary drug infusion, changes in heart rate and systemic effects were minimized. Isoproterenol (0.6-0.8 microgram/min), a nonspecific beta-agonist, reduced coronary sinus potassium concentration transiently to a nadir of 0.28 (0.15-0.43) mM (median and 95% confidence interval) below control values (n = 12). The potassium uptake, which amounted to 140 (79-202) mumol/100 g tissue, corresponding to ...
Disease modifiers in hypertrophic cardiomyopathy: Interaction between calcium, titin and beta-adrenergic receptor stimulation ...
TY - THES. T1 - Disease modifiers in hypertrophic cardiomyopathy. T2 - Interaction between calcium, titin and beta-adrenergic receptor stimulation. AU - Najafi, A.. PY - 2018. Y1 - 2018. KW - Hypertrophic cardiomyopathy; Heart disease; Heart failure. M3 - PhD Thesis - Research VU, graduation VU. ER - ...
DESENSITIZATION OF TURKEY ERYTHROCYTE ADENYLATE-CYCLASE - BETA-ADRENERGIC-RECEPTOR PHOSPHORYLATION IS CORRELATED WITH...
DESENSITIZATION OF TURKEY ERYTHROCYTE ADENYLATE-CYCLASE - BETA-ADRENERGIC-RECEPTOR PHOSPHORYLATION IS CORRELATED WITH ATTENUATION OF ADENYLATE-CYCLASE ACTIVITY
Isoprenaline - definition of isoprenaline by The Free Dictionary
Define isoprenaline. isoprenaline synonyms, isoprenaline pronunciation, isoprenaline translation, English dictionary definition of isoprenaline. or n drugs a compound that is a derivative of adrenaline and that is used to treat asthma and bronchial conditions. Formula: C11H17NO3
The effect of inosine on the inotropic response of the myocardium to isoproterenol and norepinephrine<...
TY - JOUR. T1 - The effect of inosine on the inotropic response of the myocardium to isoproterenol and norepinephrine. AU - Devous, M. D.. AU - Jones, C. E.. PY - 1978/1/1. Y1 - 1978/1/1. UR - http://www.scopus.com/inward/record.url?scp=0018249718&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018249718&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0018249718. VL - 21. JO - The Physiologist. JF - The Physiologist. SN - 0031-9376. IS - 4. ER - ...
Adrenergic drug synonyms, adrenergic drug antonyms - FreeThesaurus.com
Synonyms for adrenergic drug in Free Thesaurus. Antonyms for adrenergic drug. 1 synonym for adrenergic drug: adrenergic. What are synonyms for adrenergic drug?
Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas - Full Text View -...
Lipomas are benign, non-cancerous fatty tumors that occur under the skin and make a bump that can be easily felt and often seen. The current treatment for lipomas is surgery. Isoproterenol, a medication used for the treatment of asthma and approved for injection under the skin, is known to cause fat cells to give up their fat. The fat cells become resistant to isoproterenol with repeated use. Prednisolone, a synthetic cortisone medication used to treat immune problems like allergy and approved for injection under the skin, keeps the fat cells from becoming resistant to isoproterenol. It is not known, if the fat cells in lipomas act like other fat cells or if the combination of isoproterenol and prednisolone injections would shrink lipomas without surgery. This study is designed to test this possibility.. Subjects will have a screening visit, 2 microdialysis visits a week apart, 20 treatment visits 5 days per week for 4 weeks, and up to 12 follow-up visits a year after treatment visits. During ...
Isoproterenol and propranolol Drug Interactions - Drugs.com
A Moderate Drug Interaction exists between isoproterenol and propranolol. View detailed information regarding this drug interaction.
MEK1 binds βarrestin1 directly, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated...
cAMP is a well studied second messenger that is ubiquitously expressed in mammals. It conducts its function by activating its downstream effectors: protein kinase A (PKA), exchange proteins regulated by cAMP (EPAC) and cyclic nucleotide gated ion-channels. The sole mechanism to inactivate cAMP is through degradation via cyclic-phosphodiesterases (PDEs). The PDEs, especially PDE4s, are involved in many diseases including asthma, chronic obstructive pulmonary disease (COPD) and depression. Therefore, PDEs have been a consistently popular research subject for decades and pharmaceutical companies have devoted considerable effort in developing PDE inhibitors. β-arrestin interacts with PDE4D5 and is a multifunctional protein that plays pivotal roles in signal transduction. It functions as an adaptor protein in the c-Raf/MEK/ERK cascade by interacting with c-Raf and ERK ...
Anti-Obesity Agents - Antiobesity Drugs Summary Report | CureHunter
Anti-Obesity Agents: Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.
Effect of intense exercise training on myocardial basal | Open-i
Effect of intense exercise training on myocardial basal function and responsiveness to isoproterenol stimulation. Isoproterenol was infused to isolated hearts o
Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers (part 9)
During further development the ability of sarcoplasmic reticulum to accumulate Ca2+ increases and there is a progressive maturation of Ca2+ release from the
November, 2016 | HATs Inhibitorhatsinhibitor.com
Representative traces and indicate data showing the response of shortening (expressed as a % of resting cell size) to selective stimulation of b1-AR with one hundred nM isoproterenol (Iso) in the existence of 100 nM ICI 118,551. C, D. Representative traces and suggest information of the response of [Ca2+]i transient amplitude to selective b1-AR stimulation. Knowledge are from 200 myocytes from 7 hearts. E, F, G. Agent traces and suggest information of the reaction of ICa,L to selective stimulation of b1-AR with 10 nM Iso in the presence of ICI 118, 551 (ICI). n = six myocytes from three hearts. P,.05, Students t-take a look at. doi:ten.1371/journal.pone.0106905.g005 In standard, the results of simvastatin on basal and b-AR stimulated grownup myocyte perform are quite comparable to individuals we have noted beforehand when caveolae are disrupted with MBCD, suggesting that simvastatin is operating by way of cholesterol-dependent (caveolar) pathways. Nonetheless, presented the human body of ...
Minijet isoprenaline (discontinued in the UK)
Isoprenaline hydrochloride is a beta-adrenergic agonist which has a powerful stimulant action on the heart, increasing cardiac output and heart rate. It also increases blood flow to the limbs and extremities. Isoprenaline is a sympathomimetic medicine that dilates the small air passages in the lungs and improves the transmission of electrical signals in the heart. This medicine is given intravenously as an emergency treatment for serious heart disorders.
Adrenergic Drugs: Types, Uses, and Effects
Adrenergic drugs stimulate your sympathetic nervous system. Find out how they treat different conditions by targeting different receptors in this system.
Search of: Recruiting, Not yet recruiting, Available Studies | Cystic Fibrosis - List Results - ClinicalTrials.gov
Change in other NPD measures from baseline and Days 4, 7, and 14 to include baseline PD, change in amiloride, low chloride, and low chloride plus isoproterenol ...
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Clonidine (10(-7) M), an alpha2-agonist, induced a moderate and delayed increase of GLP-1 and PYY but abolished the isoproterenol-induced peptide secretion ...
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Read on to learn about their history, what they entail, and their impact on the businesses that employ them.ISO 9001. By far the most popular family is that of ISO 9000. … ISO 14001. ISO 14000 is a family of standards relating to the environment. … ISO 27000. … ISO 22000. … ISO 50001. … ISO/TS 16949. … ISO 13485. … ISO 31000.More items…• ...
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Laboratorul de Evaluarea Biocompatibilitatii (BIOEVAL) - DFVM - IFIN-HH
Laboratorul BIOEVAL desfasoara activitati in domeniul evaluarii sigurantei utilizarii materialelor si dispozitivelor medicale conform seriei de documente ISO 10993
In one study, a patient with bilateral insula and ACC damage was given isoproterenol as a method of exciting the cardiovascular ... Khalsa, S.S.; Rudrauf, D.; Sandesara, C.; Olshansky, B.; Tranel, D. (2009). "Bolus isoproterenol infusions provide a reliable ... This can be done pharmacologically using adrenaline-like drugs, such as isoproterenol, which mimics activation of the ... "Isoproterenol-induced panic attacks". Biological Psychiatry. 24 (8): 891-902. doi:10.1016/0006-3223(88)90224-7. PMID 3069135. ...
Isoproterenol, Isoproterenol, Isoproterenol, Isoproterenol hydrochloride, Isoproterenol sulfate, Isuprel, Isuprel, Neo-Epinine ... Isoprenaline, or isoproterenol (Brand name: Isoprenaline Macure), is a medication used for the treatment of bradycardia (slow ... Isoproterenol has been reported to cause insulin resistance leading to diabetic ketoacidosis. The adverse effects of ... "Label: Isoproterenol hydrochloride injection, solution". NIH DailyMed. September 10, 2013. Retrieved 21 June 2017. Mozayani, ...
It is methylenedioxyphenyl-isoproterenol. The Para-Methoxyamphetamine (PMA) analog is twice the potency as the tenamfetamine ...
It was initially made from isoproterenol. Dobutamine is used to treat acute but potentially reversible heart failure, such as ...
Other examples include phenylephrine, isoproterenol, and dobutamine. Stimulation of the D1 receptor by dopaminergic agonists ...
United States Adopted Name
isoproterenol moracizine. moricizine orciprenaline. metaproterenol paracetamol. acetaminophen pethidine. meperidine rifampicin ...
Sep 1984). "Bitolterol compared to isoproterenol in advanced chronic obstructive pulmonary disease". Chest. 86 (3): 404-8. doi: ... a comparison with isoproterenol hydrochloride aerosol". Ann Allergy. 56 (6): 494-9. PMID 3717716. Nathan RA, Bernstein IL, ... "Comparison of the bronchodilator effects of nebulized bitolterol mesylate and isoproterenol hydrochloride in steroid-dependent ...
Second-degree atrioventricular block
... intravenous atropine or isoproterenol may transiently improve conduction. Type 2 Second-degree AV block, also known as Mobitz ...
... effects of pharmacological challenge with isoproterenol". Psychiatry Research. 33 (1): 1-10. doi:10.1016/0165-1781(90)90143-S. ...
History of catecholamine research
C. E. Powell; I. H. Slater (1958). "Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol". Journal ... "Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol". Journal of Pharmacology and Experimental ...
Epinephrine (adrenalin) was the first of these, and next came isoprenaline (isoproterenol). Isoetharine was the third drug in ...
Johnson DA, Sreebny LM (February 1973). "Effect of isoproterenol on synthesis and secretion in the rat parotid gland". ...
Table of neurotransmitter actions in the ANS
Mauduit, P; Herman, G; Rossignol, B (1984). "Protein secretion induced by isoproterenol or pentoxifylline in lacrimal gland: ...
The ethanol extract was reported to protect rats from isoproterenol-induced myocardial injury. Momordica charantia or bitter ... "Cardioprotective Effect Of Momordica Cymbalaria Fenzl In Rats With Isoproterenol-Induced Myocardial Injury". Journal of ...
MacIcková, T; Navarová, J; Urbancíkova, M; Horáková, K (1999). "Comparison of isoproterenol-induced changes in lysosomal enzyme ...
بازدارنده آنزیم - ویکیپدیا، دانشنامهٔ آزاد
Isoproterenol) • ایزوکسوپرین • Labetalol • Levonordefrin • Levosalbutamol • مابوترول • متوکسی فنامین • متیلدوپا • N- ...
Microphthalmia-associated transcription factor
Activation of the LysRS-Ap4A-MITF signalling pathway by isoproterenol has been confirmed in cardiomyocytes. A heart specific ...
... isoproterenol, cocaine, and ionizing radiation. NF-κB suppression of tumor necrosis factor cytotoxicity (apoptosis) is due to ... AP-1 and NF-κB DNA binding activities in isoproterenol-induced cardiac remodeling". Journal of Molecular and Cellular ...
"Alteration of Ventricular Fibrillation by Propranolol and Isoproterenol Detected by Epicardial Mapping with 506 Electrodes". ...
Izoprenalin - Википедија, слободна енциклопедија
Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry. 4: 217-241. doi:10.1016/S1574-1400(08)00012-1 ...
Gaseous signaling molecules
Endogenous sulfur dioxide also diminishes myocardial damage, caused by isoproterenol adrenergic hyperstimulation, and ... "Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant ...
"Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and ...
S2CID 17923073.[dead link] Olesen, J; Hougård, K; Hertz, M (1978). "Isoproterenol and propranolol: ability to cross the blood- ...
"Coconut haustorium maintains cardiac integrity and alleviates oxidative stress in rats subjected to isoproterenol-induced ...
... intrinsic activity compared to the gold standard isoprenaline/isoproterenol). Its half maximal effective concentration (EC50) ...
"Cardioprotective effect of 'Khamira Abresham Hakim Arshad Wala' a unani formulation in isoproterenol-induced myocardial ...
These cells are also sensitive to lipogenic and lipolytic hormones, as well as drugs, including epinephrine, isoproterenol, and ...
"INaCa and ICl(Ca) contribute to isoproterenol-induced delayed after depolarizations in midmyocardial cells". Am J Physiol 1998; ...
N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol". The ...
... isoproterenol, and epinephrine in patients with asthma". The American Review of Respiratory Disease. 143 (2): 444-6. doi: ...
... isoproterenol, ISOPROTERENOL, Isoproteronol, Isoproterenol (product), Isoproterenol (substance). ... isoproterenol preparations (medication), isoproterenol preparations, Isoproterenol [Chemical/Ingredient], ... isoprenalina (producto), isoprenalina, isoproterenol, isoproterenol (producto), isoproteronol, isoprenalina (sustancia), ... Ontology: Isoproterenol. (C0022245) Definition (NCI) A synthetic catechol compound and potent beta adrenergic agonist with ...
Isoproterenol: Indications, Side Effects, Warnings - Drugs.com
Easy-to-read patient leaflet for Isoproterenol. Includes indications, proper use, special instructions, precautions, and ... What do I need to tell my doctor BEFORE I take Isoproterenol?. *If you have an allergy to isoproterenol or any other part of ... How do I store and/or throw out Isoproterenol?. *If you need to store isoproterenol at home, talk with your doctor, nurse, or ... How is this medicine (Isoproterenol) best taken?. Use isoproterenol as ordered by your doctor. Read all information given to ...
Isoproterenol and propranolol Drug Interactions - Drugs.com
Isoproterenol | GreenMedInfo | Toxic Ingredient | Natural Medicine
Astaxanthin prevented oxidative stress in the hearts and kidneys of Isoproterenol-administered aged rats.May 09, 2017. ... M. vulgare extract has strong protective effects against isoproterenol-induced myocardial infarction.Dec 31, 2013. ... Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats.Dec 06, 2017. ...
Drug: Isoproterenol | GreenMedInfo | Keyword | Natural Medicine
7 Abstracts with Drug: Isoproterenol Research. Filter by Study Type. Animal Study. ... Melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through ... Lavender essential oil protected the myocardium against isoproterenol induced myocardial infarction.Dec 31, 2014. ...
JCI - Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
JCI - Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation | SpringerLink
Isoproterenol is a nonselective beta-adrenergic agonist. The acute model mimics stress-induced cardiomyopathy. The chronic ... Isoproterenol is used widely for inducing heart failure in mice. ... Isoproterenol is used widely for inducing heart failure in mice ... Heart failure Isoproterenol Mouse model Cardiac remodeling Mouse strains Echocardiography This is a preview of subscription ... Zhuo XZ, Wu Y, Ni YJ, Liu JH, Gong M, Wang XH, Wei F, Wang TZ, Yuan Z, Ma AQ, Song P (2013) Isoproterenol instigates ...
Sensitivity and Resistance of the Myocardium to the Toxicity of Isoproterenol in Rats | SpringerLink
Alteration in sensitivity to isoproterenol and acetylcholine in the rat heart after repeated administration of isoproterenol. ... Abri, O. & Hecht, A. The influence of long-term application of isoproterenol. Experimental Pathology 20, 146-152 (1981).PubMed ... Balazs, T., Sahasrabudhe, M.R. & Grice, H.C. The influence of excess body fat on the cardiotoxicity of isoproterenol in rats. ... Rona, G., Kahn, D.S. & Chappel, C.I. Studies on infarct-like myocardial necrosis produced by isoproterenol: A review. Reviews ...
Nexus Pharmaceuticals Receives FDA Approval for Isoproterenol Hydrochloride Injection USP
Nexus Pharmaceuticals Isoproterenol Hydrochloride Injection is available as a single dose vial containing 0.2 mg per 1mL or 1 ... Nexus Pharmaceuticals Receives FDA Approval for Isoproterenol Hydrochloride Injection USP. Thursday, August 3, 2017 Drug News ... Isoproterenol Hydrochloride Injection USP is indicated for mild or transient episodes of heart block that do not require ... from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Isoproterenol ...
Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates | SRI International
Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates. December, 2014 ... HomeOur WorkPublicationsQuantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates ... Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates. Journal of Proteome ... analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol ...
Isoproterenol HCl injection Patient Assistance Program
Tell your doctor if you have: heart disease, high blood pressure, an overactive thyroid gland, epilepsy, diabetes. Tell your doctor if you ever had a bad reaction to bitolterol, ephedrine, epinephrine, metaproterenol, phenylephrine, phenylpropanolamine, pseudoephedrine, or terbutaline. Many nonprescription products contain these drugs (e.g., diet pills and medication for colds and asthma), so check the labels carefully. Do not take any of these medications without consulting your doctor (even if you never had a problem taking them before). Do not allow anyone else to take this medication. Before you use this drug, tell your doctor if you are pregnant or breast-feeding. This drug should not be used unless clearly needed if you are pregnant. ...
ISOPROTERENOL FOR SHOCK | Annals of Internal Medicine | American College of Physicians
To the Editor: I read with considerable interest the editorial "Isoproterenol for the Treatment of Shock" (Ann. Intern. Med. 70 ... FEINSILVER O. ISOPROTERENOL FOR SHOCK. Ann Intern Med. 1969;71:867. doi: 10.7326/0003-4819-71-4-867_1 ... Another consideration that might interfere with the usefulness of isoproterenol is the shunting through the lung produced by ... 638, 1969). It is clear that the author feels that isoproterenol is indicated when the balance that exists between the ...
Nitroprusside, Isoproterenol Prescribing Drops With Price Rise --Doctors Lounge
Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the ... The researchers found that the absolute number of patients treated with nitroprusside or isoproterenol decreased by 53 and 35 ... Nitroprusside, Isoproterenol Prescribing Drops With Price Rise. Last Updated: August 10, 2017. ... 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use ...
Isoproterenol Coupon and Discount
Our Isoproterenol coupons and discounts will save you up to 81% off your prescription. Get free Isoproterenol coupons on ... Drug Name: Isoproterenol. Generic name: Isoproterenol hydrochloride. The active ingredients of Isoproterenol are:. ... Isoproterenol Dosage. Isoproterenol dosage is completely dependent on the individual who takes it as it can be used for a ... Isoproterenol Side Effects. Isoproterenol, like any other drug, comes with its collection of side effects that vary with each ...
Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract
... Md. Ibrahim Khalil ... Isoproterenol [1-(3, 4-dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride (ISO)] is a synthetic catecholamine and β- ... V. S. Panda and S. R. Naik, "Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis ... We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial ...
Isoproterenol hydrochloride United States Pharmacopeia (USP) Reference Standard | (+/-)-Isoproterenol hydrochloride | Sigma...
Isoproterenol hydrochloride, 1-(3′,4′-Dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride, N-Isopropyl-DL-noradrenaline ... Isoproterenol hydrochloride United States Pharmacopeia (USP) Reference Standard; CAS Number: 51-30-9; Synonym: Isoprenaline ... Isoproterenol hydrochloride United States Pharmacopeia (USP) Reference Standard Synonym: (±)-Isoproterenol hydrochloride, 1-(3 ... HPLC Analysis of Isoproterenol Enantiomers on Astec® CHIROBIOTIC® T From our library of Articles, Sigma-Aldrich presents HPLC ...
Concealment of manifest, and exposure of concealed, ventricular parasystole produced by isoproterenol.
Intravenous isoproterenol (2 to 4 micrograms/min) was administered to 11 nonmedicated patients with ventricular parasystole. At ... Few studies have dealt with the effects of isoproterenol on ventricular parasystole. ... Few studies have dealt with the effects of isoproterenol on ventricular parasystole. Intravenous isoproterenol (2 to 4 ... Isoproterenol / adverse effects, pharmacology*. Male. Middle Aged. Myocardial Contraction / drug effects*. Sinoatrial Node / ...
Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats.
Normal rats as well as Isoproterenol induced myocardial infarcted rats were also used, which served as controls. Isoproterenol ... Home » Topics » Compliance » Research » Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats. ... Summary of "Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats.". Kombucha (Bio-tea) is a ... Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats.. 08:00 EDT 1st July 2015 , BioPortfolio ...
Abstract P205: Angiotensin II Metabolic Pathways In Isoproterenol-Induced Heart Failure: Myocytes vs Non-myocytes | Hypertension
Abstract P205: Angiotensin II Metabolic Pathways In Isoproterenol-Induced Heart Failure: Myocytes vs Non-myocytes. Sarfaraz ... Abstract P205: Angiotensin II Metabolic Pathways In Isoproterenol-Induced Heart Failure: Myocytes vs Non-myocytes ... Abstract P205: Angiotensin II Metabolic Pathways In Isoproterenol-Induced Heart Failure: Myocytes vs Non-myocytes ... Abstract P205: Angiotensin II Metabolic Pathways In Isoproterenol-Induced Heart Failure: Myocytes vs Non-myocytes ...
Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol | Cancer Research
Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol. Takehito Sasaki and Masahiko ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ... Potentiating Effect of β-Aminopropionitrile on the DNA Synthesis Induced by Isoproterenol ...
Amphastar announces FDA approval of generic isoproterenol hydrochloride injection
Isoproterenol | Profiles RNS
"Isoproterenol" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Regulation of fat specific protein 27 by isoproterenol and TNF-a to control lipolysis in murine adipocytes. J Lipid Res. 2011 ... This graph shows the total number of publications written about "Isoproterenol" by people in this website by year, and whether ... Below are the most recent publications written about "Isoproterenol" by people in Profiles. ...
Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose | Science
Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose ... Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose ... Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose ... Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose ...
Effect of isoproterenol on induction of ventricular tachyarrhythmias in the normal and infarcted canine heart.
The influence of isoproterenol on induction of ventricular arrhythmias was evaluated in 10 normal dogs and 17 dogs with ... 17 msec during isoproterenol, P = 0.3; extrastimuli 3.8 +/- 0.6 before versus 3.8 +/- 0.4 during isoproterenol infusion, P = ... The influence of isoproterenol on induction of ventricular arrhythmias was evaluated in 10 normal dogs and 17 dogs with ... Isoproterenol / pharmacology*, therapeutic use. Myocardial Infarction / drug therapy*. Tachycardia / chemically induced. ...
Molecules | Free Full-Text | Cardioprotective Effects of Puerarin-V on Isoproterenol-Induced Myocardial Infarction Mice Is...
In this research, we aim to evaluate the cardioprotective effects of puerarin-V on the isoproterenol (ISO)-induced MI mice and ... Li X, Yuan T, Chen D, Chen Y, Sun S, Wang D, Fang L, Lu Y, Du G. Cardioprotective Effects of Puerarin-V on Isoproterenol- ... In this research, we aim to evaluate the cardioprotective effects of puerarin-V on the isoproterenol (ISO)-induced MI mice and ... Cardioprotective Effects of Puerarin-V on Isoproterenol-Induced Myocardial Infarction Mice Is Associated with Regulation of ...
Comparison of the cardiocirculatory effects of exercise and isoproterenol in children with pulmonary or aortic valve stenosis. ...
Isoproterenol infusion during cardiac catheterization as a simulator of exercise was evaluated with hemodynamic studies in ... Isoproterenol induced a significantly greater decrease in systemic vascular resistance, and systemic blood pressure than did ... A consistent correlation was observed for peak valvular gradients measured during exercise and isoproterenol in both groups of ... Comparison of the cardiocirculatory effects of exercise and isoproterenol in children with pulmonary or aortic valve stenosis. ...
Comparison of the Effects of Ouabain and Isoproterenol on Ischemic Myocardium of Conscious Dogs
Isoproterenol in the presence of coronary artery occlusion increased heart rate 33 ± 4 beats/min and dP/dt 630 ± 90 mm Hg/sec ... In contrast to isoproterenol, ouabain increased flow 46 ± 9.2%, P < 0.01, systolic segment shortening 0.35 ± 0.10 mm, P < 0.01 ... SUMMARY The effects of ouabain, 20 μg/kg, and isoproterenol, 0.03 μg/kg/min, were compared in conscious dogs with acute ... In the ischemic zone, isoproterenol reduced flow by 31 + 9.1%, P < 0.01, and increased paradoxical bulging by 0.20 ± 0.07 mm, P ...
Comparative Hemodynamic Effects of Isoproterenol, Dopamine, and Dobutamine in the Newborn Dog
Isoproterenol caused a significantly greater increment of heart rate than either of the other agents to achieve a similar ... To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused ... Dopamine and dobutamine may have potential advantages over isoproterenol in augmenting cardiovascular function in young animals ... Systemic arterial mean blood pressure was increased by dopamine and dobutamine, but decreased by isoproterenol. ...
Biological sciences Cardiomyopathy Causes of Physiological aspects Heart diseases Isoproterenol Complications and side effects ... B-type natriuretic peptide and adiponectin releases in rat model of myocardial damage induced by isoproterenol administration.( ... MLA style: "B-type natriuretic peptide and adiponectin releases in rat model of myocardial damage induced by isoproterenol ... APA style: B-type natriuretic peptide and adiponectin releases in rat model of myocardial damage induced by isoproterenol ...
IsoprenalineIsuprelAgonistRatsMyocardiumSympathomimeticInfusionAdrenergicHydrochloride InjectionStimulationAbstractCalled Isoproterenol hydrochlorideDopamineExertsEffectsIngredientAmount of isoproterenolPresence of isoproterenolInjection of isoproterenolAdministration of isoproterenol2017DobutamineReceptorsSignificantlyOxidativeAdenosineSubstanceNecrosisInhibitsParotid glandInhalation SolutionCardiotoxicity2019DosesTachycardiaHeartInsulinInhibitionDrugsIncreasesEpinephrineEffectHumansEchocardiographyPropranololEnantiomersAlterations
- Isoproterenol hydrochloride or isoprenaline (Medihaler-Iso®) is a sympathomimetic beta adrenergic receptor agonist medication. (chemeurope.com)
- Isoprenaline, or isoproterenol (Brand name: Isoprenaline Macure), is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. (medschat.com)
- What is isoprenaline (isoproterenol) used for? (hellodoktor.com)
- How should I take isoprenaline (isoproterenol)? (hellodoktor.com)
- How do I store isoprenaline (isoproterenol)? (hellodoktor.com)
- What should I know before using isoprenaline (isoproterenol)? (hellodoktor.com)
- If you become pregnant while taking isoproterenol, discuss with your doctor the benefits and risks of using isoprenaline during pregnancy. (hellodoktor.com)
- Global Isoprenaline (Isoproterenol) Scope and Market Size Isoprenaline (Isoproterenol) market is segmented by company, region (country), by Type, and by Application. (marketstudyreport.com)
- Players, stakeholders, and other participants in the global Isoprenaline (Isoproterenol) market will be able to gain the upper hand as they use the report as a powerful resource. (marketstudyreport.com)
- Global Isoprenaline (Isoproterenol) Market Size Growth Rate by Type (US$ Million):2016 VS 2021 VS 2027 Table 2. (marketstudyreport.com)
- Global Isoprenaline (Isoproterenol) Market Share by Regions (2016-2021) Table 9. (marketstudyreport.com)
- Global Isoprenaline (Isoproterenol) Forecasted Market Size by Regions (2022-2027) & (US$ Million) Table 10. (marketstudyreport.com)
- Global Isoprenaline (Isoproterenol) Market Share by Regions (2022-2027) Table 11. (marketstudyreport.com)
- Isoprenaline (Isoproterenol) Market Trends Table 12. (marketstudyreport.com)
- Isoprenaline (Isoproterenol) Market Drivers Table 13. (marketstudyreport.com)
- Isoprenaline (Isoproterenol) Market Challenges Table 14. (marketstudyreport.com)
- Isoprenaline (Isoproterenol) Market Restraints Table 15. (marketstudyreport.com)
- Global Isoprenaline (Isoproterenol) Revenue by Players (2016-2021) & (US$ Million) Table 16. (marketstudyreport.com)
- Global Isoprenaline (Isoproterenol) Market Share by Players (2016-2021) Table 17. (marketstudyreport.com)
- Global Top Isoprenaline (Isoproterenol) Players by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Isoprenaline (Isoproterenol) as of 2020) Table 18. (marketstudyreport.com)
- Ranking of Global Top Isoprenaline (Isoproterenol) Companies by Revenue (US$ Million) in 2020 Table 19. (marketstudyreport.com)
- Global 5 Largest Players Market Share by Isoprenaline (Isoproterenol) Revenue (CR5 and HHI) & (2016-2021) Table 20. (marketstudyreport.com)
- Key Players Isoprenaline (Isoproterenol) Product Solution and Service Table 22. (marketstudyreport.com)
- Date of Enter into Isoprenaline (Isoproterenol) Market Table 23. (marketstudyreport.com)
- The global Isoprenaline (Isoproterenol) Market research report, published by Value Market Research, is designed to offer various market framework such as market size, portion, trends, growth path, value and factors that impact the current market dynamics over the forecast period 2020-2027. (articles87.com)
- Additionally, these tools also give an inclusive assessment of each segment in the global market of isoprenaline (isoproterenol). (articles87.com)
- The growth and trends of Isoprenaline (Isoproterenol) Industry provide a holistic approach to this study. (articles87.com)
- This section of the isoprenaline (isoproterenol) market report provides detailed data on the segments by analyzing them at country and regional level, thereby assisting the strategist in identifying the target demographics for the respective product or services with the upcoming opportunities. (articles87.com)
- This section covers the regional outlook, which accentuates current and future demand for the Isoprenaline (Isoproterenol) market across North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. (articles87.com)
- The acquisition cost of isoproterenol ( Isuprel®) has dramatically increased from approximately $60 per vial in 2012 to over $2,150 per vial today, a nearly 4000% increase. (blogspot.com)
- Isoproterenol is a nonselective beta-adrenergic agonist. (springer.com)
- Isoproterenol [1-(3, 4-dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride (ISO)] is a synthetic catecholamine and β -adrenergic agonist that is an important regulator of myocardial contractility and metabolism, thus serving as the key element of a standard model for the study of potentially beneficial effects of numerous drugs on cardiac function [ 7 ]. (hindawi.com)
- The perforated patch clamp method was used to study the effect of the agonist of beta-adrenoreceptors isoproterenol on L-type Ca 2+ current in cardiocytes of rats and ground squirrels in two states: active and hibernating. (portlandpress.com)
- Isoproterenol is a β 1 - and β 2 -adrenoceptor agonist which was commonly used to treat asthma before the more widespread use of salbutamol , which has more selective effects on the airways. (chemeurope.com)
- Nonetheless, acute treatment with the anticholinergic agent atropine and/or the adrenergic agonist isoproterenol may be warranted. (medscape.com)
- Isoproterenol is the classical beta-receptor agonist. (washington.edu)
- Intravenous infusion of the beta-adrenergic agonist isoproterenol produced a fall in the serum concentration of parathyroid hormone. (meta.org)
- The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). (pharmacycode.com)
- The calorigenic response of dystrophic hamsters (showing minimal impairment of locomotion or muscle destruction) to the β adrenergic agonist, isoproterenol, was significantly lower than that of normal hamsters at the higher concentrations (near 10 μg/Kg.min) of the infused catecholamine. (elsevier.com)
- Intra-vBNST injection of isoproterenol, a β-adrenoceptor agonist, dose-dependently produced CPA even in the absence of noxious stimulation. (jneurosci.org)
- Isoproterenol, a β-adrenergic agonist, has been shown to induce salivary gland hyperplasia. (uthscsa.edu)
- Astaxanthin prevented oxidative stress in the hearts and kidneys of Isoproterenol-administered aged rats. (greenmedinfo.com)
- Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats. (greenmedinfo.com)
- Curcumin attenuates isoproterenol induced myocardial necrosis in rats. (greenmedinfo.com)
- Balazs, T., Arena, E. & Barron, G.N. Protection against the cardiotoxic effect of isoproterenol HCl by restricted food intake in rats. (springer.com)
- Balazs, T., Sahasrabudhe, M.R. & Grice, H.C. The influence of excess body fat on the cardiotoxicity of isoproterenol in rats. (springer.com)
- We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. (hindawi.com)
- Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats. (bioportfolio.com)
- The present investigation was carried out to understand the preventive effect of Kombucha on heart weight, blood glucose, total protein, lipid profile and cardiac markers in rats with myocardial damage induced using Isoproterenol. (bioportfolio.com)
- As Bio-tea is produced by fermenting tea, the parameters were compared in rats pre-treated with normal black tea and Bio-tea for 30 days followed by subcutaneous injection of Isoproterenol (85 mg/kg body weight). (bioportfolio.com)
- Normal rats as well as Isoproterenol induced myocardial infarcted rats were also used, which served as controls. (bioportfolio.com)
- Isoproterenol induced myocardial infarcted control rats showed a significant increase in heart weight, blood glucose and cardiac markers and a decrease in plasma protein. (bioportfolio.com)
- Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats. (bioportfolio.com)
- Antioxidation Role of Different Lateral Stellate Ganglion Block in Isoproterenol-Induced Acute Myocardial Ischemia in Rats. (bioportfolio.com)
- The present study was designed to evaluate the protective effect of Glycyrrhizic acid (GA) on isoproterenol (ISO)-induced myocardial cardiotoxicity both in rats. (bioportfolio.com)
- To shed light into the paracrine mechanisms that contribute to the expression and function of the cardiac angiotensins, we investigated the comparative activity of chymase, ACE, and ACE2 in freshly isolated myocytes and non-cardiac myocytes (NCM) from the left ventricle of rats in which heart failure (HF) was induced by two injections of isoproterenol (Iso) (170 mg/kg body weight, s.c.) spaced 24 h apart. (ahajournals.org)
- Continuous intravenous infusion of ribose (200 milligrams per kilogram per hour) for 24 hours induced a marked stimulation of cardiac adenine nucleotide biosynthesis in unanesthetized and unrestrained rats that had been treated with isoproterenol subcutaneously (25 milligrams per kilogram). (sciencemag.org)
- It is shown that isoproterenol exerts a dual effect on Ca 2+ currents of rats and ground squirrels in the active state: at V h = −50 mV, the current increases, whereas at V h = −30 mV, it decreases. (portlandpress.com)
- Isoproterenol- and epinephrine-induced changes in blood glucose and tissue glycogen levels in normal and diabetic rats: the influence of alteration in endogenous insulin levels and state of nourishment. (aspetjournals.org)
- HBDH)], of insulin, and of glucose were compared in stroke-prone (SHR-DP) and control (WKY) rats 4 h after injection of isoproterenol (30 mg/kg s.c. (eurekamag.com)
- Marked differences in plasma parameters and in responsiveness to isoproterenol evidently exist between SHR-SP and WKY rats, thus providing a useful model for studying agents that might be used to prevent cardiac pathology. (eurekamag.com)
- The increase in cardiac output with isoproterenol (ISO) treatment was smaller in tail-suspended rats compared with controls. (spandidos-publications.com)
- Reduced response to isoproterenol (ISO) in the shortening amplitude and relaxation rate of cardiomyocytes has been demonstrated in 4-week tail-suspended rats ( 11 ) and is suggested to be modulated by reduced cAMP ( 12 ). (spandidos-publications.com)
- The Action of Apelin-12 and Its Analog on Hemodynamics and Cardiac Contractile Function of Rats With Isoproterenol-Induced Myocardial Lesion]. (nextbio.com)
- Heart microsomal protein from control or isoproterenol treated rats was incubated with 50 μM arachidonic acid, and arachidonic acid metabolites were determined by liquid chromatography-electron spray ionization-mass spectrometry. (aspetjournals.org)
- CYP1A1, CYP2E1, and CYP4A3 gene expression was induced in the kidney, and CYP4A3 was induced in the liver of isoproterenol-treated rats. (aspetjournals.org)
- To evaluate its therapeutic potential against cardiac fibrosis, male Wistar rats were injected with isoproterenol (5 mg/ kg) for 8-12 weeks and the aqueous TA extract was administered orally. (imedpub.com)
- Cardiotoxicity of intravenous isoproterenol in rats. (bvsalud.org)
- Background: This study determined the effect of Biochanin A (BCA) on isoproterenol (ISO) induced Myocardial Infarction (MI) in male Wistar rats. (cardiovascularhematologicalagentsinmedicinalchemistry.com)
- IMSEAR at SEARO: Changes in glycoproteins in isoproterenol-induced myocardial infarction in rats. (who.int)
- Isoproterenol is a sympathomimetic agent that has been used for treatment of cardiac and respiratory diseases such as atrio-ventricular block, cardiac arrest and asthma in human and animals . (bvsalud.org)
- Programmed stimulation (using up to 6 extrastimuli) was performed before and then during infusion of isoproterenol (2 micrograms/minute followed by 4 micrograms/minute). (biomedsearch.com)
- extrastimuli 3.8 +/- 0.6 before versus 3.8 +/- 0.4 during isoproterenol infusion, P = 0.3). (biomedsearch.com)
- We conclude that infusion of isoproterenol increases the incidence of inducible ventricular tachycardia in the infarcted heart, but does not facilitate the induction of ventricular fibrillation in infarcted or normal hearts, despite the use of an aggressive protocol for programmed stimulation. (biomedsearch.com)
- Isoproterenol infusion during cardiac catheterization as a simulator of exercise was evaluated with hemodynamic studies in children with pulmonary (15) or aortic (8) valve stenosis. (ahajournals.org)
- Cardiac function was monitored during rest, mild exercise and isoproterenol infusion. (ahajournals.org)
- Echocardiograms were recorded before and immediately after intravenous infusion of isoproterenol (0.02 μ g/kg body weight per min) for 5 min in 18 patients with typical hypertrophic cardiomyopathy (i.e., hypertrophied, hyperdynamic and nondilated) to determine the difference in fractional shortening. (onlinejacc.org)
- The present study confirmed that impaired responses to isoproterenol infusion are related to future deterioration of left ventricular performance in patients with typical hypertrophic cardiomyopathy. (onlinejacc.org)
- Oral glucose loads produced a pronounced fall in serum phosphate concentration, comparable to the fall after isoproterenol infusion, but no significant changes in serum parathyroid hormone. (meta.org)
- Local propranolol blocking of the beta-adrenergic receptors of the sinoatrial node during intravenous infusion of isoproterenol. (meta.org)
- Baseline characteristics and responses to overdrive ventricular pacing and intravenous atropine followed by an incremental isoproterenol infusion were determined. (ahajournals.org)
- In addition, isoproterenol acts on beta-2 adrenergic receptors in bronchiolar and vascular smooth muscle, thereby causing smooth muscle relaxation. (fpnotebook.com)
- Preliminary results have shown that drug-stimulated ERK phosphorylation through the β-2 adrenergic receptor for isoproterenol and several β-blockersis at least partially dependent on Src, activation of EGFR, and receptor internalization. (butler.edu)
- Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. (enaminestore.com)
- It is concluded that the fall in serum parathyroid hormone after isoproterenol is due to a beta-adrenergic effect. (meta.org)
- Isoproterenol stimulates Beta adrenergic receptors in secretory units of salivary glands and causes increasing of salivation and histomorphological changes in short and long terms, respectively. (bvsalud.org)
- from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Isoproterenol Hydrochloride Injection. (medindia.net)
- Amphastar announced FDA approval of isoproterenol hydrochloride injection, USP 0.2 mg/mL, 1mL and 0.2 mg/mL, 5-mL single-dose vial, for multiple uses including mild or transient episodes of heart block that do not require electric shock or pacemaker therapy. (aphanet.org)
- Isoproterenol is, therefore, a safe and useful adjunct to programmed stimulation in this setting. (biomedsearch.com)
- Examination of the phosphoinositide-specific phospholipase C activity in the perfused hearts revealed that isoproterenol stimulation was associated with a decrease in the membrane-associated enzymatic activity at physiological calcium concentrations. (ahajournals.org)
- Effects of sodium nitroprusside, isosorbide dinitrate, isoproterenol, phentolamine and prazosin on hepatic venous responses to sympathetic nerve stimulation in the cat. (aspetjournals.org)
- Isoproterenol increased hepatic venous tone perhaps by stimulation of angiotensin formation and the responses to stimulation of the hepatic nerves were reduced because of this increased basal tone. (aspetjournals.org)
- The activation of both cAMP accumulation and ERK phosphorylation due to stimulation of different β-2 ligands, including isoproterenol and various β-blockers, were measured using a radioactive binding assay and Western blotting technique, respectively. (butler.edu)
- Isoproterenol (ISO) 100nM was added into both kinds of K+ solution to apply the effect of β1-AR stimulation. (brad.ac.uk)
Called Isoproterenol hydrochloride1
- The generic version is called Isoproterenol hydrochloride. (rebates.com)
- To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused into anesthetized open chest puppies and cardiac output was measured, as were systemic arterial blood pressure, heart rate, and renal artery blood flow. (ovid.com)
- Systemic arterial mean blood pressure was increased by dopamine and dobutamine, but decreased by isoproterenol. (ovid.com)
- Dopamine produced a significant increase of renal artery blood flow while renal artery blood flow was unchanged by dobutamine and decreased by isoproterenol. (ovid.com)
- Dopamine and dobutamine may have potential advantages over isoproterenol in augmenting cardiovascular function in young animals. (ovid.com)
- We infused isoproterenol (0.1 μg/kg body weight per min) and dopamine (10 μg/kg per min) and measured myocardial and total body V̇ o 2 and regional blood flows in chronically instrumented 7-week old lambs with and without a left to right shunt. (onlinejacc.org)
- We conclude that the catecholamines isoproterenol and dopamine do not lead to a mismatch between myocardial oxygen supply and demand, nor do they change blood flow distribution unfavorably in 7-week old lambs with a left to right shunt. (onlinejacc.org)
- We demonstrated that isoproterenol is superior to dopamine, because it shifts the balance between oxygen supply and consumption toward supply so that systemic oxygen extraction reserve increases. (onlinejacc.org)
- In a previous study we demonstrated that in lambs with an aortopulmonary left to right shunt, isoproterenol increased systemic blood flow more than dopamine did, because isoproterenol increased heart rate  . (onlinejacc.org)
- To determine whether stellate ganglion block (SGB) treatment exerts protective effects against isoproterenol (ISO)-induced acute myocardial ischemia (AMI) due to its antioxidant effects, we aimed to e. (bioportfolio.com)
- What are some other side effects of Isoproterenol? (drugs.com)
- M. vulgare extract has strong protective effects against isoproterenol-induced myocardial infarction. (greenmedinfo.com)
- Klingman GI, McKay G, Ward A, Morse L (1973) Chronic isoproterenol treatment of mice: effects on catecholamines and rectal temperature. (springer.com)
- It is clear that the author feels that isoproterenol is indicated when the balance that exists between the beneficial effects of the drug on the circulation and delivery of oxygen exceeds the harmful effects. (annals.org)
- Isoproterenol, like any other drug, comes with its collection of side effects that vary with each who uses it. (rebates.com)
- Few studies have dealt with the effects of isoproterenol on ventricular parasystole. (biomedsearch.com)
- In this research, we aim to evaluate the cardioprotective effects of puerarin-V on the isoproterenol (ISO)-induced MI mice and elucidate the underlying mechanisms. (mdpi.com)
- Comparison of the cardiocirculatory effects of exercise and isoproterenol in children with pulmonary or aortic valve stenosis. (ahajournals.org)
- SUMMARY The effects of ouabain, 20 μg/kg, and isoproterenol, 0.03 μg/kg/min, were compared in conscious dogs with acute myocardial ischemia. (ovid.com)
- In conclusion, equi-inotropic doses of ouabain and isoproterenol induced opposite effects on the mechanical function, ECGs and blood flow of severely ischemic tissue. (ovid.com)
- The effects of isoproterenol on 32P incorporation into phospholipids and proteins were observed in the presence of prazosin, and they were completely abolished by the beta-receptor blocker propranolol. (ahajournals.org)
- These effects of acetylcholine on epicardium are attended by an accentuation of the spike and dome morphology of the action potential, are readily reversed with atropine, fail to appear when epicardium is pretreated with the transient outward current blocker 4-aminopyridine, are accentuated in the presence of isoproterenol (10(-7) to 5 x 10(-6) M), and persist in the presence of propranolol. (ahajournals.org)
- equimolar concentrations of acetylcholine completely antagonize the effects of isoproterenol in endocardium and epicardium. (ahajournals.org)
- Isoproterenol has positive inotropic and chronotropic effects on the heart. (chemeurope.com)
- The adverse effects of isoproterenol are also related to the drug's cardiovascular effects. (chemeurope.com)
- When given systemically, isoproterenol stimulates beta receptors in the heart, which produces positive inotropic and chronotropic effects. (medscape.com)
- What are the side effects of isoproterenol that I need to call my doctor about immediately? (medicine.com)
- The effects of isoproterenol (Iso) on neuronal excitability and synaptic transmission were investigated in slices of rat amygdala using intracellular recording technique. (ncku.edu.tw)
Amount of isoproterenol2
- Note that the amount of isoproterenol depends on the amount of times you plan on taking each day. (rebates.com)
- It contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of acetylcysteine (C 5 H 9 NO 3 S), and not less than 90.0 percent and not more than 115.0 percent of the labeled amount of isoproterenol hydrochloride (C 11 H 17 NO 3 ·HCl). (drugfuture.com)
Presence of isoproterenol1
- Add 100 µL of Ferro-Citrate Solution and 1.0 mL of Buffer Solution, and mix: the presence of isoproterenol hydrochloride is confirmed by the development of a purple color. (drugfuture.com)
Injection of isoproterenol1
- 0.08 g/l) after injection of isoproterenol. (eurekamag.com)
Administration of isoproterenol2
- THURSDAY, Aug. 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
- We also demonstrated that dobutamine evoked a similar hemodynamic response to that of isoproterenol, although less marked. (onlinejacc.org)
- Isoproterenol binds and stimulates beta-receptors of the heart, smooth and skeletal muscle, vasculature, and alimentary tract. (medscape.com)
- The increased pulse pressure that is apparent in this response is a reflection of the activation is isoproterenol of the beta-1 receptors in the heart muscle. (washington.edu)
- That differences between dystrophic and normal hamsters did not occur over the entire concentration range suggests that the altered responsiveness of the myopathic animals cannot be attributed solely to a decreased concentration of active catecholamine at the receptor site, a decreased number of functional receptors and/or a decreased affinity of the receptor for isoproterenol. (elsevier.com)
- The diminution of adenine nucleotides characteristic for the action of high doses of isoproterenol was entirely prevented, and the incidence of the isoproterenol-induced myocardial cell damage was significantly reduced when ribose was administered. (sciencemag.org)
- Isoproterenol did not significantly facilitate induction of ventricular fibrillation in either normal dogs or those studied after production of myocardial infarction. (biomedsearch.com)
- Peak pulmonary and aortic valve gradients as well as right and left ventricular dp/dt/p were significantly higher and cardiac index significantly lower with isoproterenol as compared to exercise. (ahajournals.org)
- Isoproterenol induced a significantly greater decrease in systemic vascular resistance, and systemic blood pressure than did exercise. (ahajournals.org)
- Isoproterenol caused a significantly greater increment of heart rate than either of the other agents to achieve a similar change of cardiac output. (ovid.com)
- The tissue levels of the inositol 1,4,5-trisphosphate isoform were also measured in hearts perfused with isoproterenol for 3 minutes, and they were found to be significantly lower compared with values obtained in control hearts. (ahajournals.org)
- Our results show that isoproterenol treatment significantly increased the heart/body weight ratio and the hypertrophic markers. (aspetjournals.org)
- Isoproterenol increased the transcript level of pro-fibrotic genes like Col1α, Col3α, Tgf-β1, and CTGF and TA extract significantly attenuated it. (imedpub.com)
- We performed microarray analyses on RNA from mice with isoproterenol-induced cardiac hypertrophy and mice with exercise-induced physiological hypertrophy and identified 865 and 2,534 genes that were significantly altered in pathological and physiological cardiac hypertrophy models, respectively. (biomedcentral.com)
- El-Demerdash E, Awad AS, Taha RM, El-Hady AM, Sayed-Ahmed MM (2005) Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat. (springer.com)
- PURPOSE: The authors studied the involvement of cAMP-dependent second messenger systems in the inhibition of rod outer segment (ROS) phagocytosis by isoproterenol (ISO) and forskolin (FSK) using two membrane-permeant analogs of cyclic adenosine monophosphate (cAMP), the Rp and Sp diastereoisomers of cyclic adenosine 3',5' monophosphothioate (cAMPS). (arvojournals.org)
- It is proposed that aminophylline and isoproterenol may increase cyclic adenosine monophosphate (AMP) and prevent platelet aggregation along the endothelial surfaces of the microcirculation, and may thereby help to maintain improved perfusion of the injured spinal cord. (elsevier.com)
- This isoproterenol-induced CPA was reversed by the coinjection of Rp-cyclic adenosine monophosphorothioate (Rp-cAMPS), a selective PKA inhibitor. (jneurosci.org)
- The filarial parasites Litomosoides carinii and Dipetalonema viteae both show transcuticular uptake of adenosine 3', 5'-cyclic monophosphate but isoproterenol is taken up by D. viteae only. (nebraska.edu)
- Below you will find a list of Isoproterenol drug and substance interactions. (rebates.com)
- Rona, G., Kahn, D.S. & Chappel, C.I. Studies on infarct-like myocardial necrosis produced by isoproterenol: A review. (springer.com)
- Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. (arvojournals.org)
- Osmium impregnation was used to show possible differences of reduction capacity of perinuclear space, rough endoplasmic reticulum and the Golgi apparatus of unstimulated mouse parotid gland and in the gland after repeated pharmacological doses of isoproterenol. (meta.org)
- The balanced regulation of up- and down-expression of genes related to cell proliferation/survival may provide a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement without tumor transformation. (uthscsa.edu)
- Acetylcysteine and Isoproterenol Hydrochloride Inhalation Solution is a sterile solution of Acetylcysteine and Isoproterenol Hydrochloride in water. (drugfuture.com)
- Color and clarity Using the Inhalation Solution as the Test solution , proceed as directed for Color and clarity under Isoproterenol Inhalation Solution . (drugfuture.com)
- Procedure Place a volume of Inhalation Solution, equivalent to about 0.26 mg of isoproterenol hydrochloride, in a test tube with 3 mL of 0.1 M mercuric chloride, and mix. (drugfuture.com)
- Assay preparation Transfer an accurately measured volume of Inhalation Solution, equivalent to about 1.5 mg of isoproterenol hydrochloride, and 10 mL of Internal standard solution to a 25-mL volumetric flask, add dilute glacial acetic acid (1 in 100) to volume, and mix. (drugfuture.com)
- 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728060/all/Isoproterenol. (unboundmedicine.com)
- Young mice chronically treated with β-aminopropionitrile (BAPN) were subsequently given injections of graded doses of isoproterenol, and the response of various tissues to IPR in synthesizing DNA was analyzed. (aacrjournals.org)
- In 4 patients, parasystolic activity ceased to be manifest when the concomitantly enhanced (by isoproterenol) sinus cycle lengths became shorter than 430 ms. This phenomenon reflected a tachycardia-dependent parasystolic concealment, presumably as a result of interference in the parasystolic-ventricular junction. (biomedsearch.com)
- Isoproterenol facilitated induction of sustained monomorphic ventricular tachycardia (cycle length 163 +/- 26 msec) in 5 of the 10 animals with no inducible baseline arrhythmia (P less than 0.05). (biomedsearch.com)
- Isoproterenol can produce an elevated heart rate (tachycardia), which predisposes patients to cardiac dysrhythmias. (chemeurope.com)
- Melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities. (greenmedinfo.com)
- Isoproterenol is used widely for inducing heart failure in mice. (springer.com)
- To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment. (sri.com)
- Isoproterenol is usually used to treat symptoms of emphysema, heart attack and bronchitis. (rebates.com)
- Effect of isoproterenol on induction of ventricular tachyarrhythmias in the normal and infarcted canine heart. (biomedsearch.com)
- Isoproterenol in the presence of coronary artery occlusion increased heart rate 33 ± 4 beats/min and dP/dt 630 ± 90 mm Hg/sec and decreased mean arterial pressure by 6.3 ± 1.6 mm Hg. (ovid.com)
- Heart weights and histology were studied 24 h after isoproterenol injection. (eurekamag.com)
- Cardiac edema induced by isoproterenol, determined as changes in heart weight and by histology, did not differ between SHR-SP and WKY. (eurekamag.com)
- Isoproterenol increased myocardial V̇ o 2 , parallel to the increase in heart rate. (onlinejacc.org)
- Increased DNA binding activities of redox sensitive transcription factors NF-κB, and AP-1 in isoproterenol treated heart was partially reversed by the TA extract. (imedpub.com)
- Because of the time base of the display, the increased heart rate also caused by isoproterenol is not apparent. (washington.edu)
- We also produced a pairwise similarity matrix to illustrate relatedness of animal models with human heart disease and identified ischemia as the human condition that most resembles isoproterenol treatment. (biomedcentral.com)
- Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle. (semanticscholar.org)
- To study the precise mechanisms regulating NKCC activity, rat soleus and plantaris muscles were stimulated ex vivo by insulin or isoproterenol (ISO). (semanticscholar.org)
- Isoproterenol has been reported to cause insulin resistance leading to diabetic ketoacidosis. (wikipedia.org)
- Isoproterenol plus FSK showed an additive effect on the inhibition of phagocytosis, suggesting that they act at two independent sites. (arvojournals.org)
- This is not a list of all drugs or health problems that interact with isoproterenol. (drugs.com)
- You must check to make sure that it is safe for you to take isoproterenol with all of your drugs and health problems. (drugs.com)
- Note that this list does not include a variety of over the counter drugs and vitamins that could also counteract and alter Isoproterenol. (rebates.com)
- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
- Umesh N. Khot, M.D., from the Cleveland Clinic, and colleagues examined the impact of price increases on physician prescribing for nitroprusside or isoproterenol using data from 47 hospitals in the Vizient (formerly University HealthSystem Consortium) database. (doctorslounge.com)
- Exposure of the hearts to 0.1 microM isoproterenol for up to 1 minute was associated with significant (up to threefold) increases in phospholamban and troponin I phosphorylation, but there was no significant increase in 32P incorporation into phospholipids. (ahajournals.org)
- However, longer exposure (2 minutes or more) to isoproterenol was associated with increases in the degree of 32P labeling of phosphatidylinositols and phosphatidic acid. (ahajournals.org)
- In hibernating ground squirrels, the dual effect of isoproterenol is not observed: isoproterenol increases Ca 2+ current at any V h values. (portlandpress.com)
- Isoproterenol produced increases in GOT, LDH and .alpha. (eurekamag.com)
- In the rat, isoproterenol (ISO) produces significant hyperglycemia only in the fasted state whereas epinephrine (EPI) produces hyperglycemia in both the fed and the fasted states. (aspetjournals.org)
- Balazs, T., Ohtake, S. & Noble, J.F. The development of resistance to the ischemic cardiopathic effect of isoproterenol. (springer.com)
- Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. (tu-dortmund.de)
- Therefore, we investigated the effect of isoproterenol-induced cardiac hypertrophy on the expression of several P450 genes and their associated P450-derived metabolites of arachidonic acid. (aspetjournals.org)
- However, treatment of cells with KCN prior to homogenization preserved the isoproterenol effect through the fractionation procedure. (elsevier.com)
- It is unknown, if isoproterenol acts directly on the parathyroid hormone secreting cell, or the fall in serum parathyroid hormone is secondary to the effect of isoproterenol on other endocrine glands or the cardiovascular system. (meta.org)
- Studies on birth defects with isoproterenol have not been done in humans. (mayoclinic.org)
- We sought to assess whether isoproterenol stress echocardiography could detect in advance in which patients hypertrophic cardiomyopathy would progress to a phase resembling dilated cardiomyopathy. (onlinejacc.org)
- Ask your doctor before using propranolol together with isoproterenol. (drugs.com)
- Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. (wikem.org)
- In the present study we intended to ascertain whether BNP and adiponectin blood level could be indicators of myocardial injury and functional alterations associated with isoproterenol administration. (thefreelibrary.com)