Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.
A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Biased signaling pathways in beta2-adrenergic receptor characterized by 19F-NMR. (1/3)

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Nitric oxide and beta-adrenergic agonist-induced bronchial arterial vasodilation. (2/3)

In anesthetized sheep, we measured bronchial blood flow (Qbr) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts/million) given for 5 min and 5 ml of aerosolized isoetharine (1.49 x 10(-2) M concentration). NO and isoetharine increased Qbr from 26.5 +/- 6.5 to 39.1 (SE) +/- 10.6 and 39.7 +/- 10.7 ml/min, respectively (n = 5). Administration of NO immediately after isoetharine further increased Qbr to 57.3 +/- 15.1 ml/min. NO synthase inhibitor N(omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 30 mg/kg, in 20 ml saline given i.v.) decreased Qbr to 14.6 +/- 2.6 ml/min. NO given three times alternately with isoetharine progressively increased Qbr from 14.6 +/- 2.6 to 74.3 +/- 17.0 ml/min, suggesting that NO and isoetharine potentiate vasodilator effects of each other. In three other sheep, after L-NAME three sequential doses of isoetharine increased Qbr from 10.2 +/- 3.4 to 11.5 +/- 5.7, 11.7 +/- 4.7, and 13.3 +/- 5.7 ml/min, respectively, indicating that effects of isoetharine are predominantly mediated through synthesis of NO. When this was followed by three sequential administrations of NO, Qbr increased by 146, 172, and 185%, respectively. Thus in the bronchial circulation, there seems to be a close interaction between adenosine 3',5'-cyclic monophosphate- and guanosine 3',5'-cyclic monophosphate-mediated vasodilation.  (+info)

Non-cAMP-mediated bronchial arterial vasodilation in response to inhaled beta-agonists. (3/3)

We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resulted in a dose-dependent increase in Qbr. With a total dose of 17.5 mg, Qbr increased from baseline values of 22 +/- 3.4 (SE) to 60 +/- 16 ml/min (P < 0.001), an effect independent of changes in cardiac output and systemic arterial pressure. To further study whether synthesis of endogenous nitric oxide (NO) affects beta-agonist-induced increases in Qbr, we administered isoetharine (20 mg) by inhalation before and after the NO-synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME). Intravenous L-NAME (30 mg/kg) rapidly decreased Qbr by approximately 80% of baseline, whereas L-NAME via inhalation (10 mg/kg) resulted in a delayed and smaller (approximately 22%) decrease. Pretreatment with L-NAME via both routes of administration attenuated bronchial arterial vasodilation after subsequent challenge with isoetharine. We conclude that isoetharine via inhalation increases Qbr in a dose-dependent manner and that beta-agonist-induced relaxation of vascular smooth muscle in the bronchial vasculature is partially mediated via synthesis of NO.  (+info)

Isoetharine is a selective beta-2 adrenergic agonist, which is a type of medication that works by stimulating the beta-2 receptors in the smooth muscle of the airways. This leads to relaxation of the muscles and increased clearance of mucus from the airways, making it easier to breathe.

Isoetharine is used as a bronchodilator to treat conditions such as asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders that cause narrowing of the airways. It is available in the form of an inhalation solution or aerosol for use with a nebulizer.

Like other beta-2 agonists, isoetharine can cause side effects such as tremors, palpitations, and increased heart rate. It should be used with caution in people with heart disease, high blood pressure, diabetes, or hyperthyroidism.

Metaproterenol is a short-acting, selective beta-2 adrenergic receptor agonist. It is primarily used as a bronchodilator to treat and prevent bronchospasms associated with reversible obstructive airway diseases such as asthma, chronic bronchitis, and emphysema. Metaproterenol works by relaxing the smooth muscles in the airways, thereby opening up the air passages and making it easier to breathe. It is available in oral (tablet or liquid) and inhalation (aerosol or solution for nebulization) forms. Common side effects include tremors, nervousness, headache, tachycardia, and palpitations.

Amino alcohols are organic compounds containing both amine and hydroxyl (alcohol) functional groups. They have the general structure R-NH-OH, where R represents a carbon-containing group. Amino alcohols can be primary, secondary, or tertiary, depending on the number of alkyl or aryl groups attached to the nitrogen atom.

These compounds are important in many chemical and biological processes. For example, some amino alcohols serve as intermediates in the synthesis of pharmaceuticals, dyes, and polymers. In biochemistry, certain amino alcohols function as neurotransmitters or components of lipids.

Some common examples of amino alcohols include:

* Ethanolamine (monoethanolamine, MEA): a primary amino alcohol used in the production of detergents, emulsifiers, and pharmaceuticals
* Serinol: a primary amino alcohol that occurs naturally in some foods and is used as a flavoring agent
* Choline: a quaternary ammonium compound with a hydroxyl group, essential for human nutrition and found in various foods such as eggs, liver, and peanuts
* Trimethylamine (TMA): a tertiary amino alcohol that occurs naturally in some marine animals and is responsible for the "fishy" odor of their flesh.

The bronchial arteries are a pair of arteries that originate from the descending thoracic aorta and supply oxygenated blood to the bronchi, bronchioles, and connected tissues within the lungs. They play a crucial role in providing nutrients and maintaining the health of the airways in the respiratory system. The bronchial arteries also help in the defense mechanism of the lungs by delivering immune cells and participating in the process of angiogenesis (the formation of new blood vessels) during lung injury or repair.

Catechols are a type of chemical compound that contain a benzene ring with two hydroxyl groups (-OH) attached to it in the ortho position. The term "catechol" is often used interchangeably with "ortho-dihydroxybenzene." Catechols are important in biology because they are produced through the metabolism of certain amino acids, such as phenylalanine and tyrosine, and are involved in the synthesis of various neurotransmitters and hormones. They also have antioxidant properties and can act as reducing agents. In chemistry, catechols can undergo various reactions, such as oxidation and polymerization, to form other classes of compounds.

Sympathomimetic drugs are substances that mimic or stimulate the actions of the sympathetic nervous system. The sympathetic nervous system is one of the two divisions of the autonomic nervous system, which regulates various automatic physiological functions in the body. The sympathetic nervous system's primary function is to prepare the body for the "fight-or-flight" response, which includes increasing heart rate, blood pressure, respiratory rate, and metabolism while decreasing digestive activity.

Sympathomimetic drugs can exert their effects through various mechanisms, including directly stimulating adrenergic receptors (alpha and beta receptors) or indirectly causing the release of norepinephrine and epinephrine from nerve endings. These drugs are used in various clinical settings to treat conditions such as asthma, nasal congestion, low blood pressure, and attention deficit hyperactivity disorder (ADHD). Examples of sympathomimetic drugs include epinephrine, norepinephrine, dopamine, dobutamine, albuterol, pseudoephedrine, and methylphenidate.

It is important to note that sympathomimetic drugs can also have adverse effects, particularly when used in high doses or in individuals with certain medical conditions. These adverse effects may include anxiety, tremors, palpitations, hypertension, arrhythmias, and seizures. Therefore, these medications should be used under the close supervision of a healthcare provider.

Isoetharine Oral Inhalation: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Isoetharine controls symptoms of asthma and other lung diseases but does not cure them. Do not stop using isoetharine without ... Before using isoetharine,. *tell your doctor and pharmacist if you are allergic to isoetharine or any other drugs. ... Isoetharine comes as an aerosol and a solution to inhale by mouth. It is used as needed to relieve symptoms but usually should ...
isoetharine; Isoetarine; Isoetarin .... Source: ChemIDplus. Deposit Date: 2012-03-21. Available Date: 2012-03-21. Modify Date: ...
Although no published data exist on the use of isoetharine during lactation, data from the related drug, terbutaline, indicate ... Isoetharine is no longer marketed in the US. ... Isoetharine No authors listed. Free Books & Documents Show ... Isoetharine is no longer marketed in the US. Although no published data exist on the use of isoetharine during lactation, data ... Isoetharine No authors listed In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of ...
Treatment of Intraoperative Bronchospasm with Nebulized Isoetharine DAVID H. SPRAGUE, M.D. DAVID H. SPRAGUE, M.D. ... DAVID H. SPRAGUE; Treatment of Intraoperative Bronchospasm with Nebulized Isoetharine. Anesthesiology 1977; 46:222-224 doi: ...
ISOETHARINE HYDROCHLORIDE. ISOETHARINE HYDROCHLORIDE. 0.08%. SOLUTION;INHALATION. Discontinued. None No. No. Approval Date(s) ...
Terbutaline, metaproterenol, isoetharine, epinephrine (adrenaline). Antidepressants. Bupropion, lithium, tricyclic ...
General Acetylcysteine is available in rubber stoppered glass vials containing 4, 10, or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride Inhalation Solution, Sterile Water for Injection, or Sterile Water for Inhalation. The 10% solution may be used undiluted.. Acetylcysteine does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. If only a portion of the solution in a vial is used for inhalation, store the remainder in a refrigerator and use within 96 hours.. Nebulization-face mask, mouth piece, tracheostomy When nebulized into a face mask, mouth piece, or tracheostomy, 1 to 10 mL of the 20% solution or 2 to 20 mL of the 10% solution may be given every 2 to 6 hours; the recommended dose for most patients is 3 to 5 mL of the 20% solution or 6 to 10 mL of the 10% solution 3 to 4 times a day.. Nebulization tent, Croupette In special circumstances it may be necessary to ...
With isoetharine this effect tended to be transient and usually went away within a matter of minutes after the end of the ... Isoetharine is a selective short-acting β2 adrenoreceptor agonist. It can be called the "granddaughter of adrenalin" in the ... Epinephrine (adrenalin) was the first of these, and next came isoprenaline (isoproterenol). Isoetharine was the third drug in ... By the late 1980s, isoetharine was largely replaced by orciprenaline (metaproterenol), which seemed to have slightly less ...
Isoetharine-isoproterenol: a comparison of effects in childhood status asthmaticus. Ann Allergy. 1982 Apr. 48(4):230-2. [QxMD ...
Isoetharine supplied in the Bronkometer unit delivers approximately 340 mcg Isoetharine. The average dose is one to two ... Other beta-adrenergic drugs such as Isoproterenol, Isoetharine, or Albuterol may be used by inhalation. The usual dose to ...
In large amounts, these medicines can be poisonous: Albuterol Bitolterol Ephedrine Epinephrine Isoetharine Isoproterenol ...
... and the agonist isoetharine (Drake et al., 2008; Liu et al., 2012) have different patterns of signaling among G protein and β- ...
Isoetharine Mesylate,N0000004968, irinotecan hydrochloride,N0000004960, Ipratropium Bromide,N0000004959, Ipodate Sodium, ... Isoetharine,N0000006297, cefpodoxime proxetil,N0000006298, amidronate,N0000006299, prednicarbate,N0000006300, Histidine, ...
ISOETHARINE 52904 ISOFLURANE 52905 ISOFLUROPHATE 52908 ISOMETHEPTENE MUCATE 52910 ISOLEUCINE 52915 ISONIAZID 52920 ISOPROPAMIDE ...
Isoetharine Mesylate Narrower Concept UI. M0011761. Registry Number. DV74WJ5PJB. Terms. Isoetharine Mesylate Preferred Term ... Isoetharine Preferred Term Term UI T022628. Date01/01/1999. LexicalTag NON. ThesaurusID ... Isoetharine Preferred Concept UI. M0011760. Registry Number. YV0SN3276Q. Related Numbers. 530-08-5. DV74WJ5PJB. Scope Note. ... Isoetharine Mesylate Pharm Action. Bronchodilator Agents. Adrenergic beta-2 Receptor Agonists. Registry Number. YV0SN3276Q. ...
acetylcysteine solution, USP () medication page for patients to search for scientific information on Pfizer medications. Also, find the prescribing information, announcements, resources, and channels to connect with Pfizer Medical Information.
Isoetharine Current Synonym true false 1236471011 Isoetarine Current Synonym true false 1237036012 Isoetharine Current Synonym ...
Isoetharine Mesylate Narrower Concept UI. M0011761. Registry Number. DV74WJ5PJB. Terms. Isoetharine Mesylate Preferred Term ... Isoetharine Preferred Term Term UI T022628. Date01/01/1999. LexicalTag NON. ThesaurusID ... Isoetharine Preferred Concept UI. M0011760. Registry Number. YV0SN3276Q. Related Numbers. 530-08-5. DV74WJ5PJB. Scope Note. ... Isoetharine Mesylate Pharm Action. Bronchodilator Agents. Adrenergic beta-2 Receptor Agonists. Registry Number. YV0SN3276Q. ...
Treatment of Intraoperative Bronchospasm with Nebulized Isoetharine DAVID H. SPRAGUE, M.D. ...
Isoetharine(Bronchodilator.). *Isoeugenol. *Isofenphos. *Isofezolac(Anti-inflammatory; antipyretic; analgesic.). *Isoflavone. * ...
Isoetharine - Preferred Concept UI. M0011760. Scope note. Adrenergic beta-2 agonist used as bronchodilator for emphysema, ... Isoetharine Mesylate - Narrower Concept UI. M0011761. Preferred term. Isoetharine Mesylate Entry term(s). Mesylate, Isoetharine ...
Isoetharine. (Bronkosol). AS, MDI. +. 6. +. Metaproterenol. (Alupent). AS, MDI, PO. -. 10. +++. Terbutaline. (Brethine). Inj, ...
Acetylcysteine is usually administered as fine nebulae and the nebulizer used should be capable of providing optimal quantities of a suitable range of particle sizes.. Commercially available nebulizers will produce nebulae of acetylcysteine satisfactory for retention in the respiratory tract. Most of the nebulizers tested will supply a high proportion of the drug solution as particles of less than 10 microns in diameter. Mitchell2 has shown that particles less than 10 microns should be retained in the respiratory tract satisfactorily.. Various intermittent positive pressure breathing devices nebulized acetylcysteine with a satisfactory efficiency including: No. 40 De Vilbiss (The De Vilbiss Co., Somerset, Pennsylvania), and the Bennett Twin-Jet Nebulizer (Puritan Bennett Corp., Oak at 13th., Kansas City, Missouri).. The nebulized solution may be inhaled directly from the nebulizer. Nebulizers may also be attached to the plastic face masks or plastic mouthpieces. Suitable nebulizers may also be ...
ANTI-ASTHMATIC AGENTS ISOETHARINE ANTI-ASTHMATIC AGENTS ISOPROTERENOL ANTI-ASTHMATIC AGENTS KHELLIN ANTI-ASTHMATIC AGENTS ... ADRENERGIC BETA-AGONISTS ISOETHARINE ADRENERGIC BETA-AGONISTS ISOPROTERENOL ADRENERGIC BETA-AGONISTS ISOXSUPRINE ADRENERGIC ... RESPIRATORY SYSTEM AGENTS ISOETHARINE RESPIRATORY SYSTEM AGENTS ISOPROTERENOL RESPIRATORY SYSTEM AGENTS KHELLIN RESPIRATORY ... ADRENERGIC AGENTS ISOETHARINE ADRENERGIC AGENTS ISOPROTERENOL ADRENERGIC AGENTS ISOXSUPRINE ADRENERGIC AGENTS LABETALOL ...
Wiki-wiki: a wiki resource centered on human protein-protein interactions

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