Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
Substances that are recognized by the immune system and induce an immune reaction.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Antibodies produced by a single clone of cells.
The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.
Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Mechanical devices that simulate the temporomandibular joints and jaws to which maxillary and mandibular casts are attached. The entire assembly attempts to reproduce the movements of the mandible and the various tooth-to-tooth relationships that accompany those movements.
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.
Transverse sectioning and repositioning of the maxilla. There are three types: Le Fort I osteotomy for maxillary advancement or the treatment of maxillary fractures; Le Fort II osteotomy for the treatment of maxillary fractures; Le Fort III osteotomy for the treatment of maxillary fractures with fracture of one or more facial bones. Le Fort III is often used also to correct craniofacial dysostosis and related facial abnormalities. (From Dorland, 28th ed, p1203 & p662)
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
The behavior of performing an act persistently and repetitively without it leading to reward or pleasure. The act is usually a small, circumscribed behavior, almost ritualistic, yet not pathologically disturbing. Examples of compulsive behavior include twirling of hair, checking something constantly, not wanting pennies in change, straightening tilted pictures, etc.
Disorder characterized by an emotionally constricted manner that is unduly conventional, serious, formal, and stingy, by preoccupation with trivial details, rules, order, organization, schedules, and lists, by stubborn insistence on having things one's own way without regard for the effects on others, by poor interpersonal relationships, and by indecisiveness due to fear of making mistakes.
A method for extinguishing anxiety by a saturation exposure to the feared stimulus situation or its substitute.
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
Persistent, unwanted idea or impulse which is considered normal when it does not markedly interfere with mental processes or emotional adjustment.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The transference of either one or both of the lungs from one human or animal to another.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The wounding of the body or body parts by branding, cutting, piercing (BODY PIERCING), or TATTOOING as a cultural practice or expression of creativity or identity.
A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)
A publication issued at stated, more or less regular, intervals.
An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM.
The profession of writing. Also the identity of the writer as the creator of a literary production.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.
Compounds that contain the Cl(=O)(=O)(=O)O- structure. Included under this heading is perchloric acid and the salts and ester forms of perchlorate.
ACETIC ACID or acetic acid esters substituted with one or more CHLORINE atoms.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A series of steps taken in order to conduct research.

Alternative pathways of T lymphocyte activation. (1/1635)

Data presented in this paper suggest that there may be two alternative pathways which T lymphocytes can use in generating a cytotoxic response to alloantigens in vitro. First, there is the pathway taken when stimulator and responder cells differ by an entire H-2 complex where Ly1+2- helper T lymphocytes respond to I region encoded lymphocyte defined differences and provide help to the Ly1-2+ cytotoxic T lymphocytes responsive primarily to K/D region encoded cytotoxicity defined determinants. Second, there is the pathway taken when stimulator and responder cells differ by only K or D region differences without an I region encoded difference; under these conditions, an Ly1+2+ cell, which does not appear to play a significant role in the development of a cytotoxic response to an entire H-2 difference, appears to play a pivotal role.  (+info)

Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines. (2/1635)

A number of antibodies generated during human respiratory syncytial virus (RSV) infection have been cloned by the phage library approach. Antibodies reactive with an immunodominant epitope on the F glycoprotein of this virus have a high affinity for affinity-purified F antigen. These antibodies, however, have a much lower affinity for mature F glycoprotein on the surface of infected cells and are nonneutralizing. In contrast, a potent neutralizing antibody has a high affinity for mature F protein but a much lower affinity for purified F protein or F protein in viral lysates. The data indicate that at least two F protein immunogens are produced during natural RSV infection: immature F, found in viral lysates, and mature F, found on infected cells or virions. Binding studies with polyclonal human immunoglobulin G suggest that the antibody responses to the two immunogens are of similar magnitudes. Competitive binding studies suggest that overlap between the responses is relatively limited. A mature envelope with an antigenic configuration different from that of the immature envelope has an evolutionary advantage in that the infecting virus is less subject to neutralization by the humoral response to the immature envelope that inevitably arises following lysis of infected cells. Subunit vaccines may be at a disadvantage because they most often resemble immature envelope molecules and ignore this aspect of viral evasion.  (+info)

Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis. (3/1635)

The interaction of the T-cell receptor with the major histocomatibility complex (MHC)-peptide complex is central to T-cell activation. Variation in the nature of the peptide bound within the groove of the MHC molecule may result in an altered T-cell response. Because some naturally processed peptides bound within the groove of the class II MHC molecule are derived from the MHC molecules themselves, we studied the inhibitory effects of synthetic class II MHC peptides on alloimmune responses in vitro. Three peptides derived from a highly conserved region of the class II MHC alpha chains inhibited the rat mixed lymphocyte response (MLR) in a dose-dependent manner, with the human HLA-DQA1 peptide also inhibiting the human and mouse MLR. No effect was seen on mitogen-induced T-cell proliferation. HLA-DQA1 inhibited cytolytic T lymphocyte (CTL) generation in a dose-response fashion, with no reduction in preformed CTL killing, suggesting that the inhibitory effect is targeted at CD4(+) T-cell function. Cell-cycle analysis by flow cytometry showed that restimulation of primed T cells in the presence of HLA-DQA1 resulted in increased apoptosis, whereas unstimulated cells were not affected. These data demonstrate that synthetic peptides derived from highly conserved regions of the class II MHC alpha chain can alter CD4(+) T-lymphocyte alloimmune responses in vitro, and this effect is mediated by the induction of apoptosis in activated T cells.  (+info)

Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A. (4/1635)

Two unrelated patients with the same Arg2150His mutation in the factor VIII (FVIII) C1 domain, a residual FVIII activity of 0.09 IU/mL, and inhibitor titres of 300 and 6 Bethesda Units, respectively, were studied. Further analysis of patient LE, with the highest inhibitor titer, showed that (1) plasma or polyclonal IgG antibodies prepared from LE plasma inhibited the activity of allogeneic (wild-type) but not of self FVIII; (2) the presence of von Willebrand factor (vWF) increased by over 10-fold the inhibitory activity on wild-type FVIII; (3) the kinetics of FVIII inhibition followed a type II pattern, but in contrast to previously described type II inhibitors, LE IgG was potentiated by the presence of vWF instead of being in competition with it; (4) polyclonal LE IgG recognized the FVIII light chain in enzyme-linked immunosorbent assay and the recombinant A3-C1 domains in an immunoprecipitation assay, indicating that at least part of LE antibodies reacted with the FVIII domain encompassing the mutation site; and (5) LE IgG inhibited FVIII activity by decreasing the rate of FVIIIa release from vWF, but LE IgG recognized an epitope distinct from ESH8, a murine monoclonal antibody exhibiting the same property. We conclude that the present inhibitors are unique in that they clearly distinguish wild-type from self, mutated FVIII. The inhibition of wild-type FVIII by LE antibody is enhanced by vWF and is associated with an antibody-dependent reduced rate of FVIIIa release from vWF.  (+info)

Isolation and characterization of monoclonal antibodies directed against murine FRP-1/CD98/4F2 heavy chain: murine FRP-1 is an alloantigen and amino acid change at 129 (P<-->R) is related to the alloantigenicity. (5/1635)

Nineteen mAb directed against murine fusion regulatory protein-1 (mFRP-1)/4F2/CD98 were isolated and their biological properties were analysed. Intriguingly, mFRP-1 was found to be an alloantigen, namely, FRP-1.1 (DBA/2 and CBA mice type) and FRP-1.2 (BALB/c, C57BL/6 and C3H/He mice type). The nucleotide sequences of FRP-1.1 and FRP-1.2 were determined, demonstrating that amino acid change at 129 (P<-->R) is related to the alloantigenicity. mFRP-1 is expressed on thymocytes, on spleen cells, on peripheral lymphocytes and on blood monocytes, suggesting that the physiological role in vivo of murine FRP-1 is different from that of human FRP-1. The biological activities of antimFRP-1 mAbs showed by the present study are: (i) enhancement of Newcastle disease virus-induced cell fusion; (ii) suppression of HIVgp160-mediated cell fusion; and (iii) induction of aggregation and multinucleated giant cells of monocytes/macrophages.  (+info)

Administration of G-CSF to normal individuals diminishes L-selectin+ T cells in the peripheral blood that respond better to alloantigen stimulation than L-selectin- T cells. (6/1635)

To determine whether administration of G-CSF induces phenotypic or functional changes in T cells, we examined peripheral blood T cells from normal individuals receiving G-CSF for activation antigen and adhesion molecule expression before and after G-CSF administration. G-CSF (10 microg/kg/day) was administered subcutaneously to 14 normal individuals for 3-5 days and their PBMC were serially analyzed with monoclonal Ab (mAb) directed to HLA-DR, CD45RO, CD45RA, CD25, CD122, CD95, CD11a, CD49d, CD44 and CD62L (L-selectin) coupled with anti-CD3 mAb. Among T cells positive for these antigens, only the proportion of T cells expressing L-selectin significantly decreased from 68% to 37% after 3-day G-CSF administration. When peripheral blood CD3+ T cells obtained before and after G-CSF administration were sorted into two populations depending on the expression of L-selectin and tested for their proliferative response to allogeneic B cells, the reactivity of L-selectin- cells to alloantigen stimulation was consistently lower than that of L-selectin+ cells regardless of the exposure to G-CSF. The decrease in the relative number of L-selectin+ cells induced by G-CSF administration may contribute to the unexpectedly low incidence of severe acute GVHD after allogeneic PBSC transplantation.  (+info)

Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. (7/1635)

Brief treatment with alphaCD154 Ab has been shown to prevent acute graft versus host disease (aGvHD). We extend these data to show that in the absence of CD154 function, donor T cells are unable to expand or generate high level anti-host CTL activity. Using transgenic (Tg) alloreactive CD8+ T cells adoptively transferred into allogeneic recipients, we show that short-term expansion of the CD8+ Tg T cells occurred in the absence of Th cells, and this short-term expansion could be facilitated with an agonistic alphaCD40. While CD40 agonism could enhance short-term expansion, sustained expansion of CD8+ Tg T cells required bona fide CD154-expressing CD4+ alloreactive Th cells. While CD154 was necessary for CD8+ Tg T cell sustained expansion, IL-2 was also implicated as essential. These observations suggest alphaCD154 therapy in GvHD is effective because the treatment causes an abortive CD8 alloresponse leading to the exhaustion or deletion of alloreactive CD8+ clones preventing the development of disease.  (+info)

T cell immunity induced by allogeneic microglia in relation to neuronal retina transplantation. (8/1635)

Microglia share a lineage relationship with bone marrow-derived monocytes/macrophages and dendritic cells, and their inclusion in retinal and brain transplants may function as "passenger leukocytes. " In other solid allografts, passenger leukocytes are the primary sources of immunogenicity, triggering alloimmune rejection. We have conducted a series of in vitro and in vivo studies examining the capacity of microglia cultured from forebrain to activate alloreactive T cells and to induce and elicit alloimmunity. Cultured microglia expressed class II MHC molecules and costimulatory molecules (B7-1, B7-2, and CD40), and they secreted IL-12. Cultured microglia injected s.c. into naive recipients induced allospecific delayed hypersensitivity and elicited delayed hypersensitivity directed at alloantigens. Cultured microglia differed from conventional APCs by secreting significant amounts of mature TGF-beta2, but smaller amounts of IL-12. Moreover, while both cultured microglia and conventional APC stimulated T cell proliferation in vitro, microglia directed the responding T cells toward the Th2 pathway in which IL-4, but not IL-2 and IFN-gamma, was secreted. The abilities of microglia to secrete TGF-beta2, to stimulate alloreactive Th2 cells, and to induce anterior chamber associated immune deviation when injected into the eye of naive allogeneic mice suggest that they are not typical passenger leukocytes. The unique functional properties of cultured microglia may account for the capacity of neonatal retinal tissue transplanted into the eye to alter the systemic alloimmune response in a manner that delays, but does not prevent, graft rejection.  (+info)

Autori: Sitaru AG, Timmermann W, Ulrichs K, Otto C.. Editorial: Hum Immunol, 2004.. Rezumat:. The indirect alloimmune response seems to be restricted to a few dominant major histocompatibility complex (MHC)-derived peptides responsible for T-cell activation in allograft rejection. The molecular mechanisms of indirect T-cell activation have been studied using peptide analogues derived from the dominant allopeptide in vitro, whereas the in vivo effects of peptide analogues have not been well characterized yet. In the present study, we generated allochimeric peptide analogues by replacing the three allogeneic amino acids 5L, 9L, and 10T in the sequence of the dominant MHC class I allopeptide P1. These allochimeric peptide analogues were used to define the allogeneic amino acids critical for the MHC binding and TCR recognition. We found that position 5 (5L) of the dominant allopeptide acts as an MHC-binding residue, while the other two allogeneic positions, 9 and 10, are important for the T-cell ...
TY - JOUR. T1 - Analysis of neonatally induced tolerance of H-2 alloantigens - II. Failure to detect alloantigen-specific T-lymphocyte precursors and suppressors. AU - Gruchalla, Rebecca S.. AU - Streilein, J. Wayne. PY - 1982/3. Y1 - 1982/3. N2 - There is a considerable amount of evidence, confirmed and extended by our studies, in favor of clonal deletion of alloantigen-reactive cells in neonatally induced transplantation tolerance. We have demonstrated in adult mice bearing long-standing skin allografts that lymphocytes specifically reactive with the tolerated H-2 alloantigens are undetectable by mixed lymphocyte and graftversus-host reactions, and in cell-mediated lympholysis. In addition, lymphoid cells capable of suppressing the reactivity of syngeneic normal lymphocytes in these assays similarly escape detection. Moreover, putative precursors of T cells specific for the tolerated antigens cannot be activated polyclonally with concanavalin A (Con A), nor can they be identified among ...
Previous studies on human Th subset development were restricted to the analysis of naive T cells activated with anti-CD3 mAb in the absence of physiologic APC. In this study, we have analyzed the role of cytokines and physiologic APC on T cell maturation in an Ag-specific system, in which naive neonatal CD4 T cells were primed with allogeneic dendritic cells (DC). We found that the cytokine profile of primed cells was dependent upon 1) the ratio between T cells and allogeneic DC and 2) the endogenous production of IL-4 and IL-12. Neutralization of IL-4 during primary MLR increased IFN-gamma production at priming and shifted the phenotype of primed cells from Th0 to Th1. These effects were IL-12 dependent, in that they were suppressed by anti-IL-12 Abs. The production of IL-12 in primary MLR was further evidenced by the presence of IL-12 p40 in the culture supernatant fluids. IL-12 production was suppressed by exogenous IL-4 and increased by anti-IL-4 blocking mAbs, indicating that endogenous ...
The plasticity of CD4+ T cell is found to be higher than previously thought and might be modified by the cross-talking among different signal pathways. On the other hand, the role of CD40-activated B cells in the differentiation of CD4+ T cell is still on debate and their underlying mechanism for inducing Tregs remains unknown. In this study, using coculture of human naïve CD4+CD25- T cells with allogeneic CD40-activated B cells without any exogenous cytokines, we have demonstrated that CD40-activated B cells could induce alloantigen-specific CD4hiCD25hi Tregs and Th1 cells from their naïve precursors under weak and optimal activation respectively. Interestingly, the induced CD4hiCD25hi Tregs had Th1 properties with high level of T-bet expression, and some of them produced IFN-gamma. Both IFN-gamma+ and IFN-gamma-CD4hiCD25hi Tregs had a similar alloantigen-specific suppressive capacity. Importantly, we further found that the endogenously produced IFN-gamma and intrinsic T-bet expression were ...
Hereditary Factors:, Organs:, Serology: Antigen, Bioassays, Techniques:, Congenic Resistant Lines: C3H.SW, B10.D2/O, Genes: H-2 - Histocompatibility-2, Strains: A(CAL-A) (A/J), AKR, AL(AL/N), BALB/C, BDP, CBA, CE, C3H, C3H/HE, C57BL, C57BL/6, C57BL/10, C57BR, C57L, C58, DBA/1 (12), DBA/2 (212), DD, L (P), LP, MA (MARSH), PL (PLA, PLB), RF (W), RIII (R3A), SJL, SM, ST/B (STB), STR (STR/1), SWR, 101, 129, BRSUNT, Unknown:. ...
The A2 allele of the platelet specific alloantigen system is encoded by rs5918(C), and it has been implicated as increasing the risk of myocardial infarction, heart disease, and resistance to blood-thinning benefits of aspirin. On its own, the A2 allele is implicated especially in early onset heart disease [PMID 8598867]; in combination with the 4G allele of the PAI1 gene, rs1799889, the increased risk of myocardial infarction in a Finnish study population was 4 fold higher (odds ratio = 4.5, p=0.001), particularly in males (odds ratio = 6.4, p=0.0005) [PMID 9700201]. Olympic skater Sergei Grinkov, who had this risk factor, died of a heart attack at age 28. [1] A2 allele carriers also appear to be relatively resistant to the anti-thrombotic (i.e. anti-clotting) actions normally associated with aspirin use.[PMID 11723016] A protective effect of rs5918 has also been observed for the development of Non-Hodgkin Lymphoma, both for the SNP (which is also known as L59P) and for its gene, ITGB3. The ...
I am looking at antibodies to neutrophil antigens. HNA-3a is one of these antigenic epitopes. I was wondering if anyone has been able to determine the actual identity of this protein. For example HNA-1 is found on CD16. HNA-2 is found on CD177. Literature searches only say that HNA-3a is found on an undetermined 50-70 kD protein. I am just curious if anybody knows the true identity of this 50-70 kD protein or a reference that may help. Thanks, for any help you can give. Jeff ...
The proliferative responsiveness of granulocyte colony-stimulating factor (G-CSF)-mobilized blood was studied in uni-directional mixed leukocyte cultures. Unfractionated mononuclear cells from mobilized blood obtained by leukapheresis at day 4 after initiation of G-CSF (G-PBMC) were hyporesponsive (31.5% +/- 9.2% response, P = .003) compared to mononuclear cells obtained from the peripheral blood before administration of G-CSF (preG-PBMC). There was great variability among donors when purified preG- and G-CD4 cells were compared. In eight of 10 donors, G-CD4 cells were equally responsive or moderately hyporesponsive; in two of 10 donors, G-CD4 cells were more strikingly hyporesponsive. CD14 cells derived from leukapheresis products (G-CD14 cells) suppressed alloantigen-induced proliferation by 48.6% +/- 7.5% when added to preG-PBMC or preG-CD4 cells at responder-CD14 ratios of 2:1 (P , .001). Suppression was evident (14.4% +/- 5.0%) even at responder-CD14 ratios of 8:1 and was largely ...
Alloimmunity (sometimes called isoimmunity) is an immune response to nonself antigens from members of the same species, which are called alloantigens or isoantigens. Two major types of alloantigens are blood group antigens and histocompatibility antigens. In alloimmunity, the body creates antibodies against the alloantigens, attacking transfused blood, allotransplanted tissue, and even the fetus in some cases. Alloimmune (isoimmune) response results in graft rejection, which is manifested as deterioration or complete loss of graft function. In contrast, autoimmunity is an immune response to the selfs own antigens. (The allo- prefix means other, whereas the auto- prefix means self.) Alloimmunization (isoimmunization) is the process of becoming alloimmune, that is, developing the relevant antibodies for the first time. Alloimmunity is caused by the difference between products of highly polymorphic genes, primarily genes of the major histocompatibility complex, of the donor and graft ...
The interaction of T helper (Th) cells with syngeneic and allogeneic cytotoxic T lymphocyte precursors (CTL.P) has been investigated. Unprimed and mixed lymphocyte culture-primed peripheral T cells were used as a source of Th. Thymocytes, which depend upon exogenous Th cells for activation, were used as a source of cytotoxic precursors. Data is presented that demonstrates that at least two pathways of T-T interaction can lead to the activation of cytotoxic lymphocytes. The first is an allogeneic effect, in which Th cells recognize and respond to alloantigens expressed on CTL.P. The second is the interaction of Th cells with syngeneic CTL.P, in which both cell types are thought to respond to alloantigens on stimulator cells. The latter interaction can be shown to be restricted by H-2-linked determinants when primed Th cells are used and allogeneic effects against thymocytes are minimized. Restricted interactions between unprimed Th cells and thymocyte CTL.P have never been observed. Mechanisms ...
Chronic allograft rejection is in part mediated by host T cells that recognize allogeneic antigens on transplanted tissue. One factor that determines the outcome of a T cell response is clonal size, while another is the effector quality. Studies of alloimmune predictors of transplant graft survival have most commonly focused on only one measure of the alloimmune response. Because differing qualities and frequencies of the allospecific T cell response may provide distinctly different information we analyzed the relationship between frequency of soluble antigen and allo-antigen specific memory IFN-g secreting CD4 and CD8 T cells, their ability to secrete IL-2, and their proliferative capacity, while accounting for cognate and bystander proliferation. The results show proliferative responses primarily reflect on IL-2 production by antigen-specific T cells, and that proliferating cells in such assays entail a considerable fraction of bystander cells. On the other hand, proliferation (and IL-2 production)
Personal Profile. Quan Liu, M.D., Ph.D., is an associate professor in the School of Medicine at SUSTech as well as a junior attending surgeon. Dr. Liu achieved his Medical Degree from Harbin Medical University (HMU) in 2002. He received his surgical training at the Second Affiliated Hospital of HMU from late 2002 through 2008 and specialized in cardiothoracic surgery. Dr. Liu moved forward for his Ph.D. degree and spent over 8 years (from 2009 to 2017) at the University of Pittsburgh. He studied transplantation immunobiology, inflammation regulation, and immunobiology of IL-33 and regulatory T cells (Treg) in the Thomas E. Starzl Transplantation Institute at the University of Pittsburgh with Drs. Heth Turnquist and Adrian Morelli.. Research. 1. Alloantigen presentation. 2. Immunobiology of IL-33, Treg and ILC2 in settings of transplantation, inflammation regulation and tumor. 3. Immunotherapy. Teaching. Undergraduate: Biochemistry, Physiology and Pathophysiology. Graduate: Immunology. Academic ...
Billington, W D.; Jenkinson, E J.; Searle, R F.; and Sellens, M H., Alloantigen expression during early embryogenesis and placental ontogeny in the mouse. Immunoperoxidase and mixed hemadsorption studies. (1977). Subject Strain Bibliography 1977. 3444 ...
Fingerprint Dive into the research topics of Maternal reactivity to fetal alloantigens is related to newborn immune responses and subsequent allergic disease. Together they form a unique fingerprint. ...
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The molecular basis of the HNA-3a/b (5b/a) leukocyte antigen system has not yet been defined despite evidence that HNA-3a… Expand ...
A soluble allogeneic effect factor (AEF) was produced by using H-2 congenic mouse strains and a serum.free cell culture medium. An AEF derived from untreated activated responder cells and irradiated stimulator cells provided helper cell function in a primary and secondary antibody response for both T-cell-depleted responder B cells and stimulator B cells. This interaction may be determined by genes situated in the I-A and I-B regions: additional K-region control was not excluded. Ia antigens, but neither H-2 nor Ig determinants are molecular constituents of AEF. The active components of this AEF consist, in part, of Ia antigens derived from both the activated responder cell population and irradiated stimulator cell population. An AEF derived from Ia negative responder cells and irradiated T-cell- depleted stimulator cells helps a secondary antibody response of T-cell- depleted stimulator B cells but not responder B cells. This genetically restricted AEF contains Ia antigens determined by the ...
The purpose of this investigation was to determine the quantitative relationship between corneal alloantigens and host immunity. In addition, the effect of the site of introduction of the corneal antigens on the host response was determined. Two alloantigenic strains of rats were reciprocally grafted at three different locations in the body with carefully quantitated amounts of corneal tissue: (1) orthotopically in the cornea of the eye; (2) subcutaneously; and (3) intraperitoneally. Corneal tissue placed orthotopically into vascularized graft beds did not elicit a systemic immune response. Subcutaneous grafts elicited a weak systemic alloantigenic response, whereas corneal tissue placed in the peritoneal cavity consistently induced a vigorous cellular and humoral alloantigenic response. Eight or more full thickness corneal allografts grafted subcutaneously were required to elicit a systemic response. On the other hand, as few as four corneal allografts placed intraperitoneally invariably ...
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Abstract. The term allorecognition refers to the series of mechanisms used by an individuals immune system to distinguish its own cells and tissues from those of another individual belonging to the same species. During evolution, different cells and molecules of both innate and adaptive immune systems have been selected to recognize and respond to antigens expressed by allogeneic cells, but not autologous cells (alloantigens). This research topic focuses on allorecognition by lymphocytes of the adaptive immune system and its involvement in rejection or tolerance of allogeneic transplants. T and B cells recognizing alloantigens via specific receptors become activated and undergo proliferation and differentiation into different types of effector and memory cells. Allorecognition by lymphocytes occurs regularly during pregnancy upon trafficking of both maternal and fetal cells. In this setting, allorecognition triggers an alloresponse that is protective towards the fetus thus preventing abortion. ...
AbstractAlloreactive T lymphocytes are the primary mediators of allograft rejection. The size and diversity of the HLA-alloreactive T cell repertoire has thus far precluded the ability to follow these T cells and thereby to understand their fate in human transplant recipients. This review summarizes
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Allogeneic bone marrow (BM) engraftment for chimerism and transplantation tolerance may be promoted by combinations of costimulation blocking biologics and small molecular weight inhibitors. We showed previously in a mouse model that anti-CD40Ligand (anti-CD40L, CD154) combined with anti-LFA-1 or everolimus (40-O-(2-hydroxyethyl)-rapamycin) resulted in stable chimerism in almost all BM recipients, whereas anti-LFA-1 plus everolimus conferred approximately 50% chimerism stability. Here, we investigated whether this lower incidence could be increased with deoxyspergualin (DSG) in place of or in addition to everolimus. However, DSG and everolimus were similarly synergistic with costimulation blockade for stable hematopoietic chimerism. This correlated with allospecific T cell depletion and inhibition of acute but not chronic skin allograft rejection. Different treatments were also compared for their inhibition of alloreactive T cell proliferation in vivo. While anti-CD40L did not impair T cell ...
Allograft rejection is the consequence of the recipients alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response ...
Graft-versus-host disease (GVHD) remains the major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). It involves complex interactions of immune cells, induction of host-reactive donor effector T cells, and donor T cell-mediated injury to normal tissues. Epigenetic changes have been implicated in T cell-mediated GVHD.. Ezh2 is a histone methyltransferase specifically catalyzing the trimethylation of histone 3 at lysine 27. Genetic ablation of Ezh2 in T cells has been shown to reduce alloreactive T cell responses and the subsequent development of GVHD.. Researchers from Dr. ZHANG Yanyuns lab at Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences revealed for the first time that Ezh2 promotes the alloreactive T cell-mediated GVHD in a H3K27me3-independent mechanism.. Inhibiting Hsp90 by its specific inhibitor AUY922 destabilized Ezh2 protein and reduced alloreactive T cell-mediated GVHD, but preserved T cell ability ...
Mesenchymal stem cells (MSCs) suppress alloantigen-induced T-cell functions in vitro and infusion of third-party MSCs seems to be a promising therapy for graft-versus-host disease (GVHD).
NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia: A new human antigen is reported which is present only on blood neut
TY - JOUR. T1 - Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis. AU - Stastny, P.. PY - 1978/4/20. Y1 - 1978/4/20. N2 - Previous testing of patients with rheumatoid arthritis showed that one HLA-D type, Dw4, occurred more frequently than in normal controls. B-cell alloantigens closely related to HLA-D can now be identified by a simple serologic procedure. Using this test, I studied 80 white patients with erosive, rheumatoid-factor-positive rheumatoid arthritis. The B-cell alloantigen HLA-DRw4 occurred in 70 per cent of 54 patients, as compared to 28 per cent of the 68 normal controls (P,10-5). Both groups were also tested for the HLA-A, B and C antigens and for HLA-D. HLA-Dw4 occurred in 54 per cent of the patients and 16 per cent of the controls (P,10-5). Small differences observed in several of the HLA-A and B antigens were not statistically significant. The results indicate that rheumatoid arthritis in whites is associated with genes of the HLA-D region and that ...
Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize
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The Granulocyte Antigen Working Party of the ISBT has formulated rules for well-defined human neutrophil antigens (HNAs), as presented in the following tabulation, although at this writing they have not met with universal acceptance., See also , Immunology, Immunoglobulins, for Fc receptor terminology and , Immunology, Lymphocytes, for CD terminology. |
The Granulocyte Antigen Working Party of the ISBT has formulated rules for well-defined human neutrophil antigens (HNAs), as presented in the following tabulation, although at this writing they have not met with universal acceptance., See also , Immunology, Immunoglobulins, for Fc receptor terminology and , Immunology, Lymphocytes, for CD terminology. |
The 5th edition of Standards for Molecular Testing for Red Cell, Platelet and Neutrophil Antigens is available until September 30, 2020 for a two week trial. The 3rd edition of Standards for a Patient Blood Management Program and 9th edition of Standards for Perioperative Autologous Blood Collection and Administration are available until December 31, 2020 for a two week free trial. Two week free trials are available from the date a set of Standards is available in the Standards Portal until their respective effective date ...
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It may be time to reconsider an AIDS vaccine which is more human than viral, triggering the immune system in a way that no other vaccine does.. 12 Comments. ...
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H-2Kk, 0.5 mg. The 36-7-5 antibody reacts with the H-2Kk MHC class I alloantigen expressed on nucleated cells from mice of the H-2Kk haplotype.
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TY - JOUR. T1 - Alloreactive T cells from individual soft agar colonies specific for guinea pig Ia antigens. I. Production and initial characterization. AU - Malek, T. R.. AU - Clark, R. B.. AU - Shevach, E. M.. PY - 1981/1/1. Y1 - 1981/1/1. N2 - Allo-reactive T cells reactive with Ia antigens from strain 2 and 13 guinea pigs were cloned by plating T cells from primary mixed leukocyte cultures in soft agar and expanding the resulting colonies in liquid culture. Optimal expansion of the cultures from an individual colony was achieved by repeated stimulation with allogeneic cells in conditioned media. Mapping studies using stimulator cells from inbred and outbred guinea pigs and blocking studies with alloantisera and xenogeneic monoclonal antibodies to guinea pig Ia antigens indicated that these T cell colonies were specifically stimulated to proliferate by Ia molecules. In addition, these xenogeneic monoclonal anti-Ia antibodies had selective and differential inhibitory effects on the ...
Allograft rejection is the consequence of the recipients alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response ...
Definition of polycythemia rubra vera. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Posttransplantation cyclophosphamide (PTCy) recently has had a marked impact on human allogeneic hematopoietic cell transplantation (HCT). Yet our understanding of how PTCy prevents graft-versus-host disease (GVHD) largely has been extrapolated from MHC-matched murine skin-allografting models that were highly contextual in their efficacy. Herein, we developed a T cell-replete, MHC-haploidentical, murine HCT model (B6C3F1→B6D2F1) to test the putative underlying mechanisms: alloreactive T cell elimination, alloreactive T cell intrathymic clonal deletion, and suppressor T cell induction. In this model and as confirmed in four others, PTCy did not eliminate alloreactive T cells identified using either specific Vβs or the 2C or 4C T cell receptors. Furthermore, the thymus was not necessary for PTCys efficacy. Rather, PTCy induced alloreactive T cell functional impairment, which was supported by highly active suppressive mechanisms established within one day after PTCy that were sufficient to ...
The ability of various B10 congenic resistant strains to respond to the alloantigen H-2.2 was tested. High and low antibody-producing strains were distinguished by their anti-H-2.2 hemagglutinating respones. However, these strains do not differ in their ability to respond to these antigenic differences in the mixed lymphocyte culture. The humoral response to the H-2.2 alloantigen was shown to be controlled by two interacting genes localized within the H-2 complex. Thus, F1 hybrids prepared between parental low responder strains could yield high level immune responses. In addition, strains bearing recombinant H-2 haplotypes were used to map the two distinct genes controlling the immune response. The alleles at each locus were shown to be highly polymorphic as evidenced by the asymmetric complementation patterns observed. The restricted interactions of specific alleles was termed coupled complementation. The significance of the results in the terms of mechanisms of Ir gene control are discussed. ...
The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate..
Serum cytokine and chemokine levels were examined in mice following 36 h of sleep deprivation, or after exposure to a known physical stressor (rotational stress). Significant changes in inflammatory cytokines/chemokines (IL-1beta, TNFalpha, IL-1ra, IL-6, and MIP-1beta, MCP-1) were observed following each manipulation, but qualitative and quantitative differences were seen. Interestingly, only physical stress was associated with measured increases in serum corticosterone levels, and with independent evidence (using in vitro immune allostimulation) for a generalized immunosuppression secondary to the experimental manipulation. Our data suggest that altered cytokine production following sleep perturbation occurs by a different mechanism from that (HPA axis) commonly attributed to stress per se.
The monoclonal antibody 1D3 was shown to be non-reactive with NK cells or monocytes but to be specific to polymorphonuclear leucocytes (PMNs). It recognizes an epitope specific to the FcγRIIIB molecule and was characterized as the sole antibody belonging to the CD16b cluster of differentiation. This antibody reacts with PMNs, irrespective of the neutrophil antigen (NA) phenotype, although it shows lower reactivity with NA2-homozygote PMNs as compared to NA1-homozygotes or NA1/NA2 heterozygotes ...
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Full text for this publication is not currently held within this repository. Alternative links are provided below where available. ...
reference: Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens., Kumar P, Vahedi-Faridi A, Saenger W, Merino E, Lopez de Castro JA, Uchanska-Ziegler B, Ziegler A, J Biol Chem. 2009 Jul 18. PMID: 19617632 ...
With the increased emphasis on transparency and cooperation counsel are forced to approach discovery with a defined strategy more than ever before. Third party discovery can and should be equally strategic.
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This statistic represents the compound annual growth rate of the third-party logistics market between 2016 and 2021, with a breakdown by region.
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Reif A., Allen J. (1966). "Mouse Thymic Iso-antigens". Nature. 209 (5022): 521-523. doi:10.1038/209521b0. PMID 5919593. h-index ...
In 1977 the University of Aberdeen published her work, The ABH Isoantigens in Cervical Malignancy. In 1978 she was meant to ... ISBN 978-978-8012-36-8. Uyanwah, Philomena Obiagliuwa (1977). The ABH Isoantigens in Cervical Malignancy. Aberdeen University. ...
Flocks RH, Boatman DL, Hawtrey CE (November 1972). "Tissue specific isoantigens in the dog prostate". Investigative Urology. 10 ...
"Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens". Proceedings of the National Academy of ...
Ly-A and Ly-B: Two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11; 170(19): 175-93. ...
... , formerly called alloantibodies, are antibodies produced by an individual against isoantigens produced by members ...
... which are called alloantigens or isoantigens. Two major types of alloantigens are blood group antigens and histocompatibility ...
Contact-Induced Cytotoxicity by Lymphoid Cells Containing Foreign Isoantigens Message Subject. (Your Name) has forwarded a page ...
"Isoantigens" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Isoantigens" by people in this website by year, and whether " ... Below are the most recent publications written about "Isoantigens" by people in Profiles. ...
ISOANTIGENS, ISOANTIBODIES AND ISOTRANSPLANTS. GORER, P. A. GORER, P. A. Less Plastic and Reconstructive Surgery and the ...
ABH isoantigens in cancer of oral tissues. Tittiranonda, Thanu Tittiranonda, Thanu Less ...
Reif A., Allen J. (1966). "Mouse Thymic Iso-antigens". Nature. 209 (5022): 521-523. doi:10.1038/209521b0. PMID 5919593. h-index ...
Alroy, J. ; Temaura, K. ; Davidsohn, I. ; Weinstein, R. S. / A method for demonstrating blood group isoantigens in permanent ... A method for demonstrating blood group isoantigens in permanent tissue sections. J. Alroy, K. Temaura, I. Davidsohn, R. S. ... Alroy, J., Temaura, K., Davidsohn, I., & Weinstein, R. S. (1978). A method for demonstrating blood group isoantigens in ... A method for demonstrating blood group isoantigens in permanent tissue sections. / Alroy, J.; Temaura, K.; Davidsohn, I.; ...
In 1977 the University of Aberdeen published her work, The ABH Isoantigens in Cervical Malignancy. In 1978 she was meant to ... ISBN 978-978-8012-36-8. Uyanwah, Philomena Obiagliuwa (1977). The ABH Isoantigens in Cervical Malignancy. Aberdeen University. ...
Unscramble letters isoantigens, Point value for isoantigens, Word Decoder for isoantigens, Word generator using the letters ... isoantigens, Word Solver isoantigens, Possible Scrabble words with isoantigens, Anagram of isoantigens ... Definition of "isoantigens" from Dictionary.com Words that start with isoantigens Words that end with isoantigens Words that ... Scrabble point value for isoantigens: 12 points. Isoantigens is a Words with Friends word. Words with Friends point value for ...
Isoantigens / biosynthesis * Isoantigens / metabolism* * Lectins, C-Type / metabolism * Lymphocyte Subsets / immunology * ...
Isoantigens / immunology* * Mice * Mice, Transgenic * Receptors, Antigen, T-Cell / genetics * Receptors, Interleukin-2 / ...
Mouse thymic iso-antigens. Nature 1966;209:521.. OpenUrlPubMed. *↵ Lansdorp PM: CDw90 cluster workshop report, in Schlossman SF ...
Isoantigens / immunology*. Leukocytes, Mononuclear / immunology*. Lupus Erythematosus, Systemic / blood, drug therapy, ... 0/Complement C3; 0/Immunosuppressive Agents; 0/Isoantigens; 315-30-0/Allopurinol; 50-18-0/Cyclophosphamide ...
Isoantigens / blood*, immunology. Mice. Microscopy, Fluorescence / methods. Obsessive-Compulsive Disorder / diagnosis*. ... 0/Antibodies, Monoclonal; 0/B-cell alloantigen D8-17; 0/Biological Markers; 0/Immunoglobulin M; 0/Isoantigens ...
TY - JOUR. T1 - Donor alloreactivity may predict acute graft-versus-host disease in HLA-matched bone marrow transplantation for leukemia in early remission. AU - Johnsen, H E. AU - Beatty, P G. AU - Michelson, E. AU - Hansen, J A. AU - Thomas, E D. PY - 1992/5. Y1 - 1992/5. KW - Acute Disease. KW - Bone Marrow Transplantation. KW - Graft vs Host Disease. KW - HLA Antigens. KW - Histocompatibility. KW - Humans. KW - Leukemia. KW - Lymphocyte Culture Test, Mixed. KW - Retrospective Studies. KW - Risk Factors. M3 - Journal article. C2 - 1386576. VL - 48. SP - 249. EP - 253. JO - European Journal of Haematology. Supplementum. JF - European Journal of Haematology. Supplementum. SN - 0902-4506. IS - 5. ER - ...
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Isoantigens [D23.050.705]. *Blood Group Antigens [D23.050.705.230]. *I Blood-Group System [D23.050.705.230.501] ...
Isoantigens [D23.050.705]. *Histocompatibility Antigens [D23.050.705.552]. *Minor Histocompatibility Antigens [D23.050.705.552. ...
al·lo·sen·si·ti·za·tion/ (al″o-sen″sĭ-tĭ-za´shun) sensitization to alloantigens (isoantigens), as to Rh antigens during ...
Categories: Isoantigens Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 3 ...
Recent developments in vaccination against malaria: The possible role of isoantigens in protective immunity to malaria*  Brown ...
... typical isoantigens are the blood group antigens.. isoantigen. (ī′sō-ăn′tĭ-jən). n.. A protein or other substance, such as ... typical isoantigens are the blood group antigens. ... For specific isoantigens of blood groups, see the Blood Groups ...
ABH cell surface isoantigens in invasive bladder carcinoma associated with schistosomiasis. Article Title:. Journal of urology. ...
"Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens". Proceedings of the National Academy of ...
Prognostic significance of flow-DNA analysis and cell surface isoantigens in carcinoma of bilharzial bladder. Urology. 1992 Mar ...
Prognostic significance of flow-DNA analysis and cell surface isoantigens in carcinoma of bilharzial bladder. Urology. 1992 Mar ...
Coon JS, Weinstein RS (1981) Detection of ABH tissue isoantigens by immunoperoxidase methods in normal and neoplastic ...
Loss of isoantigens A, B, and H in carcinoma of the lung. Am J Pathol 1969;57:307-334. ... Cuadrado E, Rodríguez-Trinidad A, Blasco E, Torrado J, Lopez García JA, Arozena F. Blood group isoantigens ABO (H) in ...
Evaluation using ABH isoantigens as endothelial markers. Lee, A.K., DeLellis, R.A., Wolfe, H.J. Am. J. Surg. Pathol. (1986) [ ...
Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens. Vrba, R., Alpert, E., Isselbacher, K.J ...
  • Typical isoantigens are the BLOOD GROUP ANTIGENS. (viictr.org)
  • al·lo·sen·si·ti·za·tion/ ( al″o-sen″sĭ-tĭ-za´shun ) sensitization to alloantigens (isoantigens), as to Rh antigens during pregnancy. (thefreedictionary.com)
  • With a few exceptions, such as the autoantigens and the isoantigens of the blood groups, antigens produce antibody only in species other than the ones from which they are derived. (thefreedictionary.com)
  • Coon JS, Weinstein RS (1981) Detection of ABH tissue isoantigens by immunoperoxidase methods in normal and neoplastic urothelium. (springer.com)
  • Several techniques have been used to demonstrate ABH isoantigens in tissue sections. (elsevier.com)
  • Expression of A and B tissue isoantigens in benign and malignant lesions of the breast. (dadamo.com)
  • This graph shows the total number of publications written about "Isoantigens" by people in this website by year, and whether "Isoantigens" was a major or minor topic of these publications. (viictr.org)
  • Appearance of cell surface auto and isoantigens during spermatogenesis in the rabbit. (medigraphic.com)
  • For specific isoantigens of blood groups, see the Blood Groups Appendix. (thefreedictionary.com)
  • The presence of sperm-specific surface isoantigens on the egg following fertilization. (semanticscholar.org)
  • In 1977 the University of Aberdeen published her work, The ABH Isoantigens in Cervical Malignancy. (wikipedia.org)