A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)
The chemical reactions involved in the production and utilization of various forms of energy in cells.
The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Organic compounds containing the radical -CSNH2.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Potassium channels where the flow of K+ ions into the cell is greater than the outward flow.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
Individual's rights to obtain and use information collected or generated by others.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Surgery performed on the heart.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
General or unspecified injuries to the heart.
The hollow, muscular organ that maintains the circulation of the blood.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
A publication issued at stated, more or less regular, intervals.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Schools which offer training in the area of health.
Terms or expressions which provide the major means of access by subject to the bibliographic unit.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.

Preconditioning in immature rabbit hearts: role of KATP channels. (1/1173)

BACKGROUND: The protective effects of ischemic preconditioning have been shown to occur in adult hearts of all species studied. We determined whether immature hearts normoxic or chronically hypoxic from birth could be preconditioned, the time window or memory of the cardioprotective effect, and the involvement of the KATP channel. METHODS AND RESULTS: Isolated immature rabbit hearts (7 to 10 days old) were subjected to 0, 1, or 3 cycles of preconditioning consisting of 5 minutes of global ischemia plus 10 minutes of reperfusion. This was followed by 30 minutes of global ischemia and 35 minutes of reperfusion. Normoxic hearts (FIO2=0.21) subjected to 1 cycle of preconditioning recovered 70+/-7% of left ventricular developed pressure compared with 43+/-8% recovery in nonpreconditioned controls. Three cycles of preconditioning did not result in additional recovery (63+/-8%). Hearts from rabbits raised from birth in hypoxic conditions (FIO2=0.12) and subjected to 1 and 3 preconditioning cycles did not show increased recovery (68+/-8% and 65+/-5%) compared with nonpreconditioned hypoxic controls (63+/-9%), although the recovery was greater in chronically hypoxic hearts than in age-matched normoxic controls. Increasing the recovery period after the preconditioning stimulus from 10 to 30 minutes resulted in a loss of cardioprotection. Pretreatment of normoxic hearts for 30 minutes with the KATP channel blocker 5-hydroxydecanoate (300 micromol/L) completely abolished preconditioning (70+/-7% to 35+/-9%) but had no effect on nonpreconditioned hearts (40+/-8%). CONCLUSIONS: Immature hearts normoxic from birth can be preconditioned, whereas immature hearts hypoxic from birth cannot. Preconditioning in normoxic immature hearts is associated with activation of the KATP channel.  (+info)

Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. (2/1173)

Previous results from our laboratory have suggested that morphine can attenuate neutrophil activation in patients with acute myocardial infarction. To elucidate if morphine preconditioning (PC) has the same effects via activation of neutrophil endopeptidase 24.11 (NEP), we measured serum levels of intercellular adhesion molecule-1 (ICAM-1), gp100MEL14 and NEP in adult Wistar rats subjected to ten different protocols (n = 10 for each) at baseline, immediately after and 2 h after morphine PC. All groups were subjected to 30 min of occlusion and 2 h of reperfusion. Similarly, morphine-induced PC was elicited by 3-min drug infusions (100 micrograms/kg) interspersed with 5-min drug-free periods before the prolonged 30-min occlusion. Infarct size (IS), as a percentage of the area at risk (AAR), was determined by triphenyltetrazolium staining. Pretreatment with morphine increased NEP activities (9.86 +/- 1.98 vs. 5.12 +/- 1.10 nmol/mg protein in control group; p < 0.001). Naloxone (mu-opioid receptor antagonist) (4.82 +/- 1.02 nmol/mg protein) and phosphoramidon (NEP inhibitor) (4.66 +/- 1.00 nmol/mg protein) inhibited morphine-activated NEP, whereas glibenclamide (ATP-sensitive potassium channel antagonist) and chelerythrine (protein kinase C inhibitor) had no effects. The ICAM-1 and gp100MEL14 of the third sampling were lowest for those with morphine PC (280 +/- 30 ng/ml and 2.2 +/- 0.7 micrograms/ml; p < 0.001), but naloxone (372 +/- 38 ng/ml and 3.8 +/- 0.9 micrograms/ml) and phosphoramidon (382 +/- 40 ng/ml and 4.2 +/- 1.1 micrograms/ml) abolished the above phenomenon. IS/AAR were definitely lowest for those with morphine PC (24 +/- 7%; p < 0.05). Morphine preconditioning increases NEP activities to attenuate shedding of gp100MEL14 and to ICAM-1 and, thus, provides myocardial protection.  (+info)

Attenuation of myocardial injury due to oxygen free radicals (OFR) by pretreatment with OFR or calcitonin gene-related peptide. (3/1173)

AIM: To study the cardioprotective effects of oxygen free radicals (OFR) and calcitonin gene-related peptide (OGRP) pretreatment on myocardial damages due to OFR in isolated perfused rat heart. METHODS: The hearts were perfused in a Langendorff mode. OFR were generated by electrolysis of Krebs-Henseleit (K-H) solution. RESULTS: OFR pretreatment reduced the impairment of cardiac contractile function, the decrease of coronary flow and the increase of creatinine kinase (CK) release due to OFR, and the effect exhibited period dependence and cycle-dependence. 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C, abolished the protection of OFR pretreatment (CK release = 110 +/- 7, 215 +/- 23, 169 +/- 14, 240 +/- 30, and 113 +/- 19 kU.L-1 for control, OFR, OFR pretreatment, OFR pretreatment plus H-7, and H-7, respectively). CGRP pretreatment also protected the myocardium damages elicited by OFR in isolated perfused rat heart. CONCLUSIONS: OFR or CGRP pretreatment protected myocardium against injury elicited by OFR, and the effect of OFR pretreatment was related to the activation of PKC.  (+info)

Cardioprotection by opening of the K(ATP) channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization. (4/1173)

AIMS: To assess the anti-ischaemic and anti-arrhythmic effects and overall safety of nicorandil, an ATP sensitive potassium (K+) channel opener, with 'cardioprotective' effects, in patients with unstable angina. METHODS: In a multicentre, randomized, double-blind, parallel-group, placebo-controlled study, oral nicorandil 20 mg twice daily or a matching placebo was administered for a minimum of 48 h to patients admitted with unstable angina. Treatment was standardized to include, where tolerated, oral aspirin, a beta-blocker and diltiazem. Continuous Holter ECG monitoring was performed for 48 h to assess the frequency and duration of transient myocardial ischaemia and any tachyarrhythmia, as the predefined end-points of the study. A pain chart recorded the incidence and severity of chest pain throughout the study period. Patients with myocardial infarction identified retrospectively from troponin-T analysis were excluded. RESULTS: Two hundred and forty-five patients were recruited into the study. Forty-three patients were excluded with an index diagnosis of myocardial infarction, two were not randomized and 12 had unsatisfactory tape data. In the remaining 188 patients, six out of 89 patients (6.7%) on nicorandil experienced an arrhythmia, compared with 17 out of 99 patients (17.2%) on placebo (P=0.04). Three nicorandil patients experienced three runs of non-sustained ventricular tachycardia compared to 31 runs in 10 patients on placebo (P=0.087 patients; P<0.0001 runs). Three nicorandil patients had four runs of supraventricular tachycardia, compared to 15 runs in nine patients on placebo (P=0.14 patients; P=0.017 runs). Eleven (12.4%) patients on nicorandil had 37 episodes of transient myocardial ischaemia (mostly silent) compared with 74 episodes in 21 (21.2%) patients on placebo (P=0.12 patients; P=0.0028 episodes). In the overall safety analysis, which included all patients who received at least one dose of study medication, there were no significant differences in the rates of myocardial infarction or death between the nicorandil or placebo-treated groups. CONCLUSIONS: Nicorandil, added to aggressive anti-anginal treatment for unstable angina, reduces transient myocardial ischaemia, non-sustained ventricular, and supraventricular arrhythmia compared to placebo. The anti-arrhythmic activity with nicorandil is probably a secondary effect resulting from its anti-ischaemic action and we suggest that this may be related to its effect on the ATP sensitive potassium channel causing pharmacological preconditioning.  (+info)

Mechanisms of isoflurane-induced myocardial preconditioning in rabbits. (5/1173)

BACKGROUND: Isoflurane has cardioprotective effects that mimic the ischemic preconditioning phenomenon. Because adenosine triphosphate-sensitive potassium channels and adenosine receptors are implicated in ischemic preconditioning, the authors wanted to determine whether the preconditioning effect of isoflurane is mediated through these pathways. METHODS: Myocardial infarct size was measured in seven groups of propofol-anesthetized rabbits, each subjected to 30 min of anterolateral coronary occlusion followed by 3 h of reperfusion. Groups differed only in the pretreatments given, and controls received no pretreatment. An ischemia-preconditioned group was pretreated with 5 min of coronary occlusion and 15 min of reperfusion. An isoflurane-preconditioned group was pretreated with 15 min end-tidal isoflurane, 1.1%, and then 15 min of washout. An isoflurane-plus-glyburide group was administered 0.33 mg/kg glyburide intravenously before isoflurane pretreatment. An isoflurane plus 8-(p-sulfophenyl)-theophylline (SPT) group received 7.5 mg/kg SPT intravenously before isoflurane. Additional groups were administered identical doses of glyburide or SPT, but they were not pretreated with isoflurane. Infarct size and area at risk were defined by staining. Data were analyzed by analysis of variance or covariance. RESULTS: Infarct size, expressed as a percentage of the area at risk (IS:AR) was 30.2+/-11% (SD) in controls. Ischemic preconditioning and isoflurane preexposure reduced myocardial infarct size significantly, to 8.3+/-5% and 13.4+/-8.2% (P<0.05), respectively. Both glyburide and SPT pretreatment eliminated the preconditioning-like effect of isoflurane (IS:AR = 30.0+/-9.1% and 29.2+/-12.6%, respectively; P = not significant). Neither glyburide nor SPF alone increased infarct size (IS:AR = 33.9+/-7.6% and 31.8+/-12.7%, respectively; P = not significant). CONCLUSIONS: Glyburide and SPT abolished the preconditioning-like effects of isoflurane but did not increase infarct size when administered in the absence of isoflurane. Isoflurane-induced preconditioning and ischemia-induced preconditioning share similar mechanisms, which include activation of adenosine triphosphate-sensitive potassium channels and adenosine receptors.  (+info)

Effects of K(ATP) channel blockade by glibenclamide on the warm-up phenomenon. (6/1173)

AIMS: The increased tolerance to myocardial ischaemia observed during the second of two sequential exercise tests, i.e. the warm-up phenomenon, has been proposed as a clinical model of ischaemic preconditioning. As ATP-sensitive K+ channels appear to be a mediator of ischaemic preconditioning in both experimental and clinical studies, the aim of this study was to investigate the role of K(ATP) channels in the warm-up phenomenon. METHODS AND RESULTS: Twenty-six patients with coronary artery disease were randomized to receive 10 mg oral glibenclamide, a selective ATP-sensitive K+ channel blocker, or placebo. Sixty minutes after glibenclamide or placebo administration, patients were given an infusion of 10% dextrose (8 ml x min(-1)) to correct glucose plasma levels or, respectively, an infusion of saline at the same infusion rate. Thirty minutes after the beginning of the infusions, both patient groups underwent two consecutive treadmill exercise tests, with a recovery period of 15 min to re-establish baseline conditions. Before exercise tests, blood glucose levels were similar in placebo and glibenclamide groups (96 +/- 10 vs 105 +/- 22 mg x 100 ml(-1), P=ns). After placebo administration, rate-pressure product at 1.5 mm ST-segment depression significantly increased during the second exercise test compared to the first (220 +/- 41 vs 186 +/- 29 beats x min(-1) x mmHg x 10(2), P<0.01), but it did not change after glibenclamide (191 +/- 34 vs 187 +/- 42 beats x min(-1) x mmHg x 10(2), P=ns), with a significant drug-test interaction (P=0.0091, at two-way ANOVA). CONCLUSIONS: Glibenclamide, at a dose previously shown to abolish ischaemic preconditioning during coronary angioplasty, prevents the increase of ischaemic threshold observed during the second of two sequential exercise tests. These findings confirm that ischaemic preconditioning plays a key role in the warm-up phenomenon and that in this setting is, at least partially, mediated by activation of ATP-sensitive K+ channels.  (+info)

Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning. (7/1173)

Although isoform-selective translocation of protein kinase C (PKC) epsilon appears to play an important role in the late phase of ischemic preconditioning (PC), the mechanism(s) responsible for such translocation remains unclear. Furthermore, the signaling pathway that leads to the development of late PC after exogenous administration of NO in the absence of ischemia (NO donor-induced late PC) is unknown. In the present study we tested the hypothesis that NO activates PKC and that this is the mechanism for the development of both ischemia-induced and NO donor-induced late PC. A total of 95 chronically instrumented, conscious rabbits were used. In rabbits subjected to ischemic PC (six 4-minute occlusion/4-minute reperfusion cycles), administration of the NO synthase inhibitor Nomega-nitro-L-arginine (group III), at doses previously shown to block the development of late PC, completely blocked the ischemic PC-induced translocation of PKCepsilon but not of PKCeta, indicating that increased formation of NO is an essential mechanism whereby brief ischemia activates the epsilon isoform of PKC. Conversely, a translocation of PKCepsilon and -eta quantitatively similar to that induced by ischemic PC could be reproduced pharmacologically with the administration of 2 structurally unrelated NO donors, diethylenetriamine/NO (DETA/NO) and S-nitroso-N-acetylpenicillamine (SNAP), at doses previously shown to elicit a late PC effect. The particulate fraction of PKCepsilon increased from 35+/-2% of total in the control group (group I) to 60+/-1% after ischemic PC (group II) (P<0.05), to 54+/-2% after SNAP (group IV) (P<0.05) and to 52+/-2% after DETA/NO (group V) (P<0.05). The particulate fraction of PKCeta rose from 66+/-5% in the control group to 86+/-3% after ischemic PC (P<0.05), to 88+/-2% after SNAP (P<0.05) and to 85+/-1% after DETA/NO (P<0.05). Neither ischemic PC nor NO donors had any appreciable effect on the subcellular distribution of PKCalpha, -beta1, -beta2, -gamma, -delta, - micro, or -iota/lambda; on total PKC activity; or on the subcellular distribution of total PKC activity. Thus, the effects of SNAP and DETA/NO on PKC closely resembled those of ischemic PC. The DETA/NO-induced translocation of PKCepsilon (but not that of PKCeta) was completely prevented by the administration of the PKC inhibitor chelerythrine at a dose of 5 mg/kg (group VI) (particulate fraction of PKCepsilon, 38+/-4% of total, P<0.05 versus group V; particulate fraction of PKCeta, 79+/-2% of total). The same dose of chelerythrine completely prevented the DETA/NO-induced late PC effect against both myocardial stunning (groups VII through X) and myocardial infarction (groups XI through XV), indicating that NO donors induce late PC by activating PKC and that among the 10 isozymes of PKC expressed in the rabbit heart, the epsilon isotype is specifically involved in the development of this form of pharmacological PC. In all groups examined (groups I through VI), the changes in the subcellular distribution of PKCepsilon protein were associated with parallel changes in PKCepsilon isoform-selective activity, whereas total PKC activity was not significantly altered. Taken together, the results provide direct evidence that isoform-selective activation of PKCepsilon is a critical step in the signaling pathway whereby NO initiates the development of a late PC effect both after an ischemic stimulus (endogenous NO) and after treatment with NO-releasing agents (exogenous NO). To our knowledge, this is also the first report that NO can activate PKC in the heart. The finding that NO can promote isoform-specific activation of PKC identifies a new biological function of this radical and a new mechanism in the signaling cascade of ischemic PC and may also have important implications for other pathophysiological conditions in which NO is involved and for nitrate therapy.  (+info)

Is the development of myocardial tolerance to repeated ischemia in humans due to preconditioning or to collateral recruitment? (8/1173)

OBJECTIVES: The purpose of this study in patients with quantitatively determined, poorly developed coronary collaterals was to assess the contribution of ischemic as well as adenosine-induced preconditioning and of collateral recruitment to the development of tolerance against repetitive myocardial ischemia. BACKGROUND: The development of myocardial tolerance to repeated ischemia is nowadays interpreted to be due to biochemical adaptation (i.e., ischemic preconditioning). METHODS: In 30 patients undergoing percutaneous transluminal coronary angioplasty, myocardial adaptation to ischemia was measured using intracoronary (i.c.) electrocardiographic (ECG) ST segment elevation changes obtained from a 0.014-in. (0.036 cm) pressure guidewire positioned distal to the stenosis during three subsequent 2-min balloon occlusions. Simultaneously, an i.c. pressure-derived collateral flow index (CFI, no unit) was determined as the ratio between distal occlusive minus central venous pressure divided by the mean aortic minus central venous pressure. The study patients were divided into two groups according to the pretreatment with i.c. adenosine (2.4 mg/min for 10 min starting 20 min before the first occlusion, n = 15) or with normal saline (control group, n = 15). RESULTS: Collateral flow index at the first occlusion was not different between the groups (0.15 +/- 0.10 in the adenosine group and 0.13 +/- 0.11 in the control group, p = NS), and it increased significantly and similarly to 0.20 +/- 0.14 and to 0.19 +/- 0.10, respectively (p < 0.01) during the third occlusion. The i.c. ECG ST elevation (normalized for the QRS amplitude) was not different between the two groups at the first occlusion (0.25 +/- 0.13 in the adenosine group, 0.25 +/- 0.19 in the control group). It decreased significantly during subsequent coronary occlusions to 0.20 +/- 0.15 and to 0.17 +/- 0.13, respectively. There was a correlation between the change in CFI (first to third occlusion; deltaCFI) and the respective ST elevation shift (deltaST): deltaST = -0.02 to 0.78 x deltaCFI; r = 0.54, p = 0.02. CONCLUSIONS: Even in patients with few coronary collaterals, the myocardial adaptation to repetitive ischemia is closely related to collateral recruitment. Pharmacologic preconditioning using a treatment with i.c. adenosine before angioplasty does not occur. The variable responses of ECG signs of ischemic adaptation to collateral channel opening suggest that ischemic preconditioning is a relevant factor in the development of ischemic tolerance.  (+info)

Results At baseline, patients were older (p,0.001) and percentage of male was higher (p,0.001) in the PC group. The PC group had higher DAS28 (3/CRP) (p,0.001) and poorer physical function (p,0.001), and received lower dosage of methotrexate (p,0.001). Percentage of patients receiving prednisolone (PSL) more than 7.5mg/day (p=0.001) and that of patients who had diabetes mellitus (DM) (p,0.001) were also higher in the PC group. There were 65 SIs (40 for pulmonary, 11 for skin and subcutaneous tissue, 14 other infections) in the PC group, and 89 SIs (42 for pulmonary, 21 for skin and subcutaneous tissue, 26 other infections) in the non-PC group. The crude incidence rate ratios comparing the PC group with the non-PC group were 2.8 (2.1-4.0) for all SIs and 3.7 (2.4-5.8) for pulmonary infections. Multivariate analyses revealed that age by decade (HR [95% CI], 1.8 [1.4-2.3]), presence of DM (1.9 [1.0-3.4]) and use of PSL ≥7.5mg/day (2.1 [1.2-3.7]) were significant risk factors for SIs in the PC ...
Dive into the research topics of Physical activity for coronary heart disease: Cardioprotective mechanisms and effects on prognosis. Together they form a unique fingerprint. ...
A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates cardiac protection pacing sequences including at least one postconditioning sequence to protect the heart from a detected ischemic event and a plurality prophylactic preconditioning sequences to protect the heart from probable future ischemic events.
A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
The present results demonstrate that IPC slightly but significantly attenuates the initial Na+ accumulation during ischemia and completed the [Na+]i recovery after 6 minutes of reperfusion compared with that in non-IPC hearts. In particular, when the recovery process was assessed by the time constant in the regression with %Δ[Na+]i=(100−α)exp(−t/τ)+α,1 time constants (τ) were not significantly different between control (1.09±0.20 minutes) and IPC hearts (1.30±0.17 minutes, P,0.05), but the irreversible accumulation (α) was significantly smaller in IPC hearts (1.03±0.80 versus 37.3±3.88 minutes in control, P,0.05). This indicates that the number of the irreversibly injured myocytes is significantly reduced in IPC hearts.. It was reported that IPC stimulates Na+ accumulation during ischemia.18 Although this was detected by 23Na-MRS, the appropriate methods to improve the resolution between intra- and extracellular Na+ peaks were not applied. In contrast, we carefully measured to ...
Conditioning refers to endogenous mechanisms rendering the myocardium more tolerant against reperfusion injury. Application of brief ischemia-reperfusion cycles prior to the index ischemia has a beneficial effect and limits the infarct size. This is
Read this full essay on Preconditions of Long Distance Trade - History 1 Honors - Assignment. Some of the necessary preconditions for long distance trades to...
Coronary Artery disease is one of the leading causes of death in china, followed by cancer. According to US CDC (Centre for Disease Control), cardiovascular disease is also the leading cause of death of men and women in the United States. Factors including hereditary and family history, nutrition and lifestyle, hypertension, high lipids and cholesterol etc, will increase the risk for cardiovascular diseases. A persons unique genetic makeup will also impact their responses to drugs eg. dosage, side effects etc. Cardiac Protection Genetic Test is conducted a CAP and CLIA accredited genetic laboratory in California US.. ...
22. Resources: Information and OSH Chapter Editor: Jukka Takala Table of Contents Figures and Tables Information: A Precondition for ActionJukka Taka...
Ischemic heart disease (IHD) is currently the leading cause of morbidity and mortality in the developed world, and is set to become the leading cause of death in the world by the year 2020, according to the World Health Organisation. Patients with severe IHD that require coronary artery bypass graft (CABG) surgery, although protected by techniques such as cross-clamp fibrillation and cardioplegia, still sustain significant myocardial injury as evidenced by perioperative troponin T or I or CK-MB release. Novel treatment strategies are required to limit the myocardial injury sustained by patients undergoing CABG surgery in order to improve the clinical outcomes of this patient group.. One such cardioprotective strategy is remote ischemic preconditioning(RIPC) which describes the cardioprotection obtained from inducing ischemia in tissue or an organ remote from the heart. Our laboratory and others have established RIPC using forearm ischemia (induced by an automated cuff applied to the upper arm) ...
Remote ischemic preconditioning (rIPC) induced by cycles of transient limb ischemia and reperfusion is a powerful cardioprotective strategy with additional pleiotropic effects. However, our understanding of its underlying mediators and mechanisms remains incomplete. Researchers at the Hospital for Sick Children
In this study, we demonstrated that PC potentiated activation of survival pathways through PI-3 kinase signaling. Inhibition of PI-3 kinase with LY294002 abolished the protective effect of PC by stimulating apoptosis and DNA fragmentation without affecting LDH release from the myocytes. These data suggest that PI-3 kinase has an important role the in antiapoptotic effects of PC. Hypoxia followed by reoxygenation (H/R) was associated with both apoptotic and necrotic cell death, whereas hypoxia contributed to only a minimal amount of cell death. Therapeutic reperfusion is currently performed without any measure to protect myocardium from apoptosis during the treatment of myocardial infarction.23 Our results indicate that it may be possible to further limit the infarct size by inhibition of apoptosis, and PI-3 kinase might play a key role in this process. PC also stimulates phosphorylation of Akt, a kinase directly downstream of PI-3 kinase. Pretreatment with LY294002 blocks the PC-induced increase ...
Opioids have been previously shown to confer acute and delayed cardioprotection against a prolonged ischemic insult. We have extensively characterized the signal transduction pathway mediating acute cardioprotection and have suggested a role for extracellular signal regulated kinase (ERK) in this ca …
Start to kinetics experiment from the second window and type multi_zgvd to start acquisition. This command will start the acquisition and ask you for a) the number of spectra, b)?? and c)??. Each of your spectra will be recorded in a diffent window using consecutive filenames. Keep in mind that you can accumulate huge amounts of data in this type of experiment ...
The Common Prolog database may be used to record factual information but it is distinct from the object base in that it may contain variables, and anything in it is inaccessible to the forward chaining rule preconditions.. ...
Objectives. Pharmacological treatment of reperfusion injury using insulin and GSK3β inhibition has been shown to be cardioprotective, however, their interaction with the endogenous cardioprotective strategy, ischemic postconditioning, is not known. Design. Langendorff perfused ex vivo rat hearts were subjected to 30 min of regional ischemia and 120 min of reperfusion. For the first 15 min of reperfusion hearts received either vehicle (Ctr), insulin (Ins) or a GSK3β inhibitor (SB415286; SB41), with or without interruption of ischemic postconditioning (IPost; 3 × 30 s of global ischemia). In addition, the combination of insulin and SB41 for 15 min was assessed. Results. Insulin, SB41 or IPost significantly reduced infarct size versus vehicle treated controls (IPost 33.5 ± 3.3%, Ins 33.5 ± 3.4%, SB41 30.5 ± 3.0% vs. Ctr 54.7 ± 6.8%, p , 0.01). Combining insulin and SB415286 did not confer additional cardioprotection compared to the treatments given alone (SB41 + Ins 26.7 ± 3.5%, ns). ...
Introduction: In the current study, protective effect of natural honey applied during ischemia/reperfusion (I/R) was studied on infarct size in ischemic heartheart. Methods: Ischemic hearthearts (n=8 per group) were mounted on a Langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. In control ...
Ischaemic preconditioning is the most powerful endogenous mechanism for limiting myocardial infarct size in the experimental setting. Its clinical application is limited to scenarios in which the index episode of ischaemia and reperfusion can be anticipated such as in the setting of cardiac surgery • Ischaemic postconditioning represents an endogenous cardioprotective strategy which is applied at the onset of myocardial reperfusion, thereby allowing its use as an adjunct to reperfusion in patients presenting with an acute myocardial infarction • Both ischaemic preconditioning and postconditioning recruit a common signal transduction pathway at the time of myocardial reperfusion, which can be targeted by pharmacological agents administered as adjuncts to reperfusion. ...
TY - THES. T1 - Systemic response to local ischaemia: the evolving concept of remote ischaemic preconditioning. AU - Saxena, Pankaj. PY - 2009. Y1 - 2009. N2 - [Truncated abstract] Life on our planet is possible because of oxygen. All mammals, including humans, evolved with an innate mechanism by which organs and cells may protect themselves against lack or excess of oxygen to some extent. This lack and excess of oxygen that occurs during interruption and restoration of blood supply to an organ is referred to as ischaemia-reperfusion (IR). IR is a ubiquitous phenomenon that accounts for a number of pathophysiological conditions. A prolonged period of ischaemia followed by reperfusion causes IR injury and leads to significant damage to the affected organ. The activation of a systemic inflammatory response is associated with the most detrimental effects of IR injury. It has been noticed that brief episodes of intermittent ischaemia applied locally render significant protection against subsequent ...
Previous studies have shown that cyclooxygenase-2 (COX-2) mediates the late phase of ischemic preconditioning (PC) by producing various cardioprotective prostanoids including prostacyclin (PGI2) and prostaglandin (PG) E2 (PGE2). Prostanoids are known to act via activation of specific receptors. However, the specific PG receptors responsible for the salubrious actions of COX-2 in PC and myocardial ischemia/reperfusion injury remain unclear. The PGI2 receptor (IP) mediates the actions of PGI2 and PGE2, the two major COX-2-derived prostanoids with cardioprotective properties. Accordingly, the goal of this study was to determine the role of the IP in late PC. C57BL/6 mice underwent a 30-min coronary occlusion (O) followed by 24 h of reperfusion (R). Administration of the IP receptor selective antagonist, RO 3244794 (group III, 10 mg/kg i.p.), 30 min prior to the 30-min O had no appreciable effect on infarct size compared with untreated and vehicle-treated groups (68.4 ± 1.2 % vs. 63.3 ± 3.1 % and ...
Hypoxic preconditioning was shown to improve the therapeutic efficacy of bone fragments marrow-derived multipotent mesenchymal stromal cells (MSCs) upon transplantation in ischemic tissue. delicate to simulated ischemia when they had been preconditioned for 24 l, while their simple behavior, karyotype and immunophenotype in lifestyle remained unrevised. Right here, post-ischemic cell amount and metabolic activity had been improved and caspase-3/7 activity and lactate dehydrogenase discharge had been decreased as likened to non-preconditioned cells. Phosphorylation of Poor and AKT, mRNA reflection of BCL-XL, VEGF and BAG1, and VEGF proteins release had been higher in preconditioned cells. Preconditioned cable bloodstream MSCs improved HUVEC growth and migration Hypoxically, while nitric Rostafuroxin (PST-2238) manufacture oxide creation continued to be unrevised. We finish that hypoxic preconditioning defends cable bloodstream MSCs by account activation of anti-apoptotic signaling systems and ...
Ischemia associated injury of the myocardium is caused by oxidative damage during reperfusion. Myocardial protection by ischemic preconditioning (IPC) was shown to be mediated by a transient iron-signal that leads to the accumulation of apoferritin and sequestration of reactive iron released during the ischemia. Here we identified the source of this iron signal and evaluated its role in the mechanisms of cardiac protection by hypoxic preconditioning. Rat hearts were retrogradely perfused and the effect of proteasomal and lysosomal protease inhibitors on ferritin levels were measured. The iron-signal was abolished, ferritin levels were not increased and cardiac protection was diminished by inhibition of the proteasome prior to IPC. Similarly, double amounts of ferritin and better recovery after ex vivo ischemia-and-reperfusion (I/R) were found in hearts from in vivo hypoxia pre-conditioned animals. IPC followed by normoxic perfusion for 30 min (delay) prior to I/R caused a reduced ferritin
TY - JOUR. T1 - Cost-effectiveness of strain-targeted cardioprotection for prevention of chemotherapy-induced cardiotoxicity. AU - Nolan, Mark T.. AU - Plana, Juan Carlos. AU - Thavendiranathan, Paaladinesh. AU - Shaw, Leslee. AU - Si, Lei. AU - Marwick, Thomas H.. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Background: Cancer chemotherapy increases the risk of heart failure. This cost-effectiveness model compared strain-guided cardioprotection with other protective strategies using a health care payer perspective and five-year time horizon. Methods: Three cardioprotection strategies were assessed: 1) usual care (EF-guided cardioprotection, EFGCP) with cardioprotection initiated on diagnosis of LVEF-defined cardiotoxicity (EF-CTX), 2) universal cardioprotection (UCP) for all such patients, and 3) strain-guided cardioprotection (SGCP - treatment of patients with subclinical cardiotoxicity [S-CTX]). A Markov model, informed by the published literature on transitional probabilities, costs and ...
The expression of Hes1 is increased following myocardial infarct and other ischemic cardiomyopathies, but the role of Hes1 in cardioprotection provided by ischemic postconditioning (IPost) remains unclear. In this study, we used gain and loss of func
Hyperglycemia-Induced Inhibition of DJ-1 Expression Compromised the Effectiveness of Ischemic Postconditioning Cardioprotection in Rats. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
In an effort to combat the evolving difficulties that encompass the cardiovascular care of patients with cancer and cancer survivors, ACC.15 is debuting a special Cardio-Oncology Intensive Session that recognizes the growth and complexity of a field that spans different cardiology subspecialties, cardiac team members and diverse oncology areas.. The aim of this intensive is to use new methods to discuss highly relevant clinical questions in the cardiovascular care of cancer patients, says Bonnie Ky, MD, intensive co-chair. We have carefully designed this experience to involve many of the worlds leading experts in cardio-oncology and have specifically incorporated key clinical questions facing us today as we care for this growing population.. Among the clinical questions to be addressed and answered will be insights into the identification of patients at high cardiovascular risk, planned cancer treatment and cardioprotective strategies prior, during and after cancer therapy, and cardiotoxic ...
Innate immune signaling is important in the pathophysiology of ischemia/reperfusion (stroke) induced injury and recovery. Several lines of evidence support a central role for microglia in these processes. Recent work has identified Toll-like receptors (TLRs) and type I interferon (IFN) signaling in both ischemia/reperfusion-induced brain injury and ischemic preconditioning-mediated neuroprotection. To determine the effects of ischemia/reperfusion-like conditions on microglia we carried out genomic analyses on wild-type (WT) and TLR4-/- cultured microglia following sequential exposure to hypoxia/hypoglycemia and normoxia/normoglycemia (H/H-N/N). We observed increased expression of type 1 IFN-stimulated genes (ISGs) as the predominant transcriptomal feature of H/H-N/N-exposed WT, but not TLR4-/-, microglia. Microarray analysis on ex vivo sorted microglia from ipsilateral male mouse cortex following a transient in vivo ischemic pulse also demonstrated robust expression of ISGs. Type 1 IFNs, ...
Although extensive attention has been devoted to the window of preconditioning, only few studies investigated the efficacy of preconditioning against ischemia with increasing durations. To date, a ceiling of protection has been demonstrated to occur with early preconditioning but nothing is known about delayed preconditioning. Accordingly, the efficacy of a nitric oxide (NO)-donor-induced delayed preconditioning was tested against ischemic insults of increasing duration. Accordingly, 65 rabbits received a 75-min intravenous infusion of either saline (control group), or an NO-donor (S-nitroso-N-acetylpenicillamine) at 3 μg/kg/min (SNAP-3 group) or 30 μg/kg/min (SNAP-30 group). Twenty-four hours later, rabbits randomly underwent either a 15-, 20-, or a 30-min coronary artery occlusion (CAO). Infarct size was assessed after 72-h reperfusion (triphenyltetrazolium chloride staining, percentage of the area at risk). After 15-min CAO, both SNAP-3 and SNAP-30 reduced infarct size compared with ...
Cardioprotection encompasses several regimens that have shown to preserve function and viability of cardiac muscle cell tissue subjected to ischemic insult or reoxygenation. Cardioprotection includes strategies that are implemented before an ischemic event (preconditioning, PC), during an ischemic event (perconditioning, PerC) and after the event and during reperfusion (postconditioning, PostC). These strategies can be further stratified by performing the intervention locally or remotely, creating classes of conditioning known as remote ischemic PC (RIPC), remote ischemic PostC and remost ischemic PerC. Classical (local) preconditioning has an early phase with an immediate onset lasting 2-3 hours that protects against myocardial infarction. The early phase involves post-translational modification of preexisting proteins, brought about by the activation of G protein-coupled receptors as well as downstream MAPKs and PI3/Akt. These signaling events act on the ROS-generating mitochondria, activate ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Hewlett-Packard will combine its personal-computer and printing units, the latest big move in new Chief Executive Meg Whitmans effort to turn around the company, George Stahl reports on the News Hub.
Volatile anesthetics not only induce anesthesia, but also render organs resistant against ischemic damage. For example, the magnitude of an experimentally induced myocardial infarct size can be reduced by more than 50% by the administration of volatile anesthetics, even if the administration has been discontinued prior to the ischemic injury (anesthetic-induced preconditioning, APC). These protective effects are also effective in other organ systems; e.g. the brain. APC is as effective as ischemic preconditioning and thus represents one of the most potent therapeutic strategies of infarct size reduction. Surgery-related temporary ischemia of the heart or the brain can be prevented using APC in the perioperative period ...
Preconditioning, the phenomenon whereby brief episodes of ischemia or pharmacological agents protect the myocardium against subsequent ischemic injury, consists of an early and a late phase.1 The early phase develops immediately and disappears within 1 to 2 hours of ischemic preconditioning stimulus, whereas the late phase, also known as the second window of protection, becomes manifest after 12 to 24 hours and lasts for 3 to 4 days. An understanding of the signaling mechanisms that trigger and mediate this cardioprotective phenomenon would have vast physiological and pathological implications. Accordingly, many recent studies have focused on the characterization and delineation of the signal transduction pathways (molecules) underlying the development and manifestation of both the early and late phases of preconditioning. The general hypothesis is that the preconditioning stimulus will induce the activation of a cascade of stress-responsive kinases, which in turn transduce the stress signal ...
Vasculitides are a heterogeneous group of autoimmune diseases, all characterized by inflammation of blood vessels (vasculitis) and subsequent ischemia and dama…
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Writer Jenny Cook digs for the truth about what having a precondition like prediabetes or prehypertension really means for your health.
Well, 1st, it depends on what you choose to use as a starting point to measure your natural. (sorry for the delay, by the way). Life is a sophisticated carbon-based nanotechnology and it heavily relies on preconditions. Where did the preconditions for the complex life come from? AstraSequi , on the previous page, used dice in the example ( If you roll a pair of dice, your chance of a double 6 is quite low (1/36). However, if you try… a hundred times times, ...it would be more surprising if you didnt get it at least once. ) What if I give you a pair of dice with no 6 present on them at all, how many tries do you need to roll a double 6? Ive tried to make this point several times… Why do you assume that preconditions just happened? For instance, what known cosmic law states that every universe popping into existence must have so many constants in physics? What known cosmic law requires nuclear resonances in the creation of fundamental blocks of life (Carbon and Oxygen, in our case) to be ...
Well, 1st, it depends on what you choose to use as a starting point to measure your natural. (sorry for the delay, by the way). Life is a sophisticated carbon-based nanotechnology and it heavily relies on preconditions. Where did the preconditions for the complex life come from? AstraSequi , on the previous page, used dice in the example ( If you roll a pair of dice, your chance of a double 6 is quite low (1/36). However, if you try… a hundred times times, ...it would be more surprising if you didnt get it at least once. ) What if I give you a pair of dice with no 6 present on them at all, how many tries do you need to roll a double 6? Ive tried to make this point several times… Why do you assume that preconditions just happened? For instance, what known cosmic law states that every universe popping into existence must have so many constants in physics? What known cosmic law requires nuclear resonances in the creation of fundamental blocks of life (Carbon and Oxygen, in our case) to be ...
The scene with the windows seemed a bit too intense to me. The emotions change so quickly that it is quite difficult to keep up, especially since the feelings are so extreme. My advice would be to draw out those scenes a bit, maybe with the Judge talking or explaining in between instead of after, so the readers have a chance to get invested before moving on to the second window ...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim of the study was to unveil the unknown and possible cardioprotective targets that can be exerted by sitagliptin (Sitg) against ischemia-reperfusion (I/R) injury. Male wistar rats received 2 weeks’ Sitg oral treatment of different doses (25, 50, 100, and 150 mg/kg/day), or saline as a Control. Hearts were then isolated and subjected to two different I/R injury protocols: 10 min perfusion, 45 min regional ischemia, and 120 min reperfusion for infarct size (IS) measurement, or: 10 min perfusion, 45 min regional ischemia and 10 min reperfusion for biochemical analysis: nitric oxide synthases (NOSs) and DPP-4 activity, glucagon-like peptide-1 (GLP-1), Calcium, transient receptor potential vanilloid (TRPV)-1 and calcitonin gene-related peptide (CGRP) levels, transient receptor potential canonical (TRPC)-1 and e-NOS protein expression. NOS inhibitor (l
Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study explores if cardioprotection afforded by short intermittent BNP administration involves PI3K/Akt/p70s6k dependent signaling, and whether this signaling pathway may participate in regulation of BNP mRNA expression at early reperfusion. Isolated Langendorff perfused rat hearts were subjected to 30 min of regional ischemia and 120 min of reperfusion (IR). Applying intermittent 3 × 30 s infusion of BNP peptide in a postconditioning like manner (BNPPost) reduced infarct size by ,50% compared to controls (BNPPost 17 ± 2% vs. control 42 ± 4%, p , 0.001). Co-treatment with inhibitors of the PI3K/Akt/p70s6k pathway (wortmannin, SH-6 and rapamycin) completely abolished the infarct-limiting effect of BNP postconditioning (BNPPost + Wi 36 ± 5%, BNPPost + SH-6 41 ± 4%, BNPPost + Rap ...
Abstract Introduction: This article aims to provide a narrative review of the most recent primary literature on the pathways associated with the neuroprotective effects of remote ischaemic post-conditioning (RIPC) in …. ...
TY - JOUR. T1 - Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. AU - Gumina, Richard J.. AU - Pucar, Darko. AU - Bast, Peter. AU - Hodgson, Denice M.. AU - Kurtz, Christopher E.. AU - Dzeja, Petras P.. AU - Miki, Takashi. AU - Seino, Susumu. AU - Terzic, Andre. PY - 2003/6/1. Y1 - 2003/6/1. N2 - Although ischemic preconditioning induces bioenergetic tolerance and thereby remodels energy metabolism that is crucial for postischemic recovery of the heart, the molecular components associated with preservation of cellular energy production, transfer, and utilization are not fully understood. Here myocardial bioenergetic dynamics were assessed by 18O-assisted 31P-NMR spectroscopy in control or preconditioned hearts from wild-type (WT) or Kir6.2-knockout (Kir6.2-KO) mice that lack metabolism-sensing sarcolemmal ATP-sensitive K+ (KATP) channels. In WT vs. Kir6.2-KO hearts, preconditioning induced a significantly higher total ATP turnover (232 ± 20 vs. ...
Size Reduction Equipment Factory - Select 2018 high quality Size Reduction Equipment Factory products in best price from certified Chinese Particle Size Reduction manufacturers, Eps Size Reduction suppliers, wholesalers and factory on Made-in-China.com
14. A blister passage as claimed in claim 13, wherein the windows are arranged in at least one row of at least first, second and third windows, with the second window between the first and third windows, said row of windows is located between two substantially parallel edge portions of the panel, each two adjacent windows in said row are separated by finger portions projecting from said edge portions respectively of the panel, each finger portion has a proximal end at which it is attached to the respective edge portion and a distal end that is spaced from the proximal end, the distal ends of the finger portions define said opening communicating with said two adjacent windows, the blister sheet has at least first, second and third blisters received by the first, second and third windows respectively and includes at least one duct interconnecting each two adjacent blisters, and said opening between the first and second windows accommodates the duct or ducts that interconnect the first and second ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
Iran says it wont take part in next weeks international peace conference on Syria if preconditions are set for its participation.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Union Process is a trusted provider of particle size reduction equipment and supplies, including grinding balls, Attritors, product and laboratory mills, and bead mills.
Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism.: We used two experimental models to prove that re
A 25 year old woman presents with blurred vision and pain with movements of her left eye for 2 days. Further questioning reveals that she experienced a brief episode of numbness in her left forearm around 6 months ago, which resolved spontaneously. Her medical history is otherwise unremarkable and she is not on any medications ...
Can t believe this subject hasn t been brought up. This stuff is infecting more everyday. I ve read the mortality rate was 2% when we first heard about it. Now I m reading 12-19% depending on where you read about it. I ve also read that it mostly kills the elderly and those with precondition health conditions like diabetes. I ve read that it is affecting those who have type A- blood more than others. They re saying you could be asymptomatic for 21-24 days. Some are prepping for a quarantine.
Our aim is to help create thriving communities with new homes, new jobs and a better environment. And we know that the starting point - indeed the fundamental precondition - must be to unlock the Gateways economic potential.
a/gfx/layers/ipc/CompositorChild.cpp +++ b/gfx/layers/ipc/CompositorChild.cpp @@ -31,16 +31,17 @@ namespace mozilla { namespace layers { /*static*/ CompositorChild* CompositorChild::sCompositor; Atomic,int32_t, CompositableForwarder::sSerialCounter(0); CompositorChild::CompositorChild(ClientLayerManager *aLayerManager) : mLayerManager(aLayerManager) + , mCanSend(true) { } CompositorChild::~CompositorChild() { } void @@ -50,16 +51,17 @@ CompositorChild::Destroy() mLayerManager = nullptr; // start from the end of the array because Destroy() can cause the // LayerTransactionChild to be removed from the array. for (int i = ManagedPLayerTransactionChild().Length() - 1; i ,= 0; --i) { RefPtr,LayerTransactionChild, layers = static_cast,LayerTransactionChild*,(ManagedPLayerTransactionChild()[i]); layers-,Destroy(); } + MOZ_ASSERT(!mCanSend); SendStop(); } bool CompositorChild::LookupCompositorFrameMetrics(const FrameMetrics::ViewID aId, FrameMetrics& aFrame) { SharedFrameMetricsData* data = ...
"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning". ... Cardioprotection includes strategies that are implemented before an ischemic event (preconditioning, PC), during an ischemic ... remote ischemic PostC and remost ischemic PerC. Classical (local) preconditioning has an early phase with an immediate onset ... Murry, CE; Jennings, RB; Reimer, KA (November 1986). "Preconditioning with ischemia: a delay of lethal cell injury in ischemic ...
"Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury ... significant threat to myocardial function that arises with the reintroduction of blood flow to the heart following an ischemic ... The mitochondria has been known to protect the heart from ischemic-reperfusion injury through the opening of the ATP-sensitive ... A major topic of research is the impact of hydrogen sulfide on reducing myocardial ischemia-reperfusion injury. Reperfusion ...
... and in the demonstration of the clinical utility of remote ischemic preconditioning in patients with acute myocardial ... 2015). "Remote Ischemic Conditioning". Journal of the American College of Cardiology. 65 (2): 177-195. doi:10.1016/j.jacc. ... 2011). "CaMKII in myocardial hypertrophy and heart failure". Journal of Molecular and Cellular Cardiology. 51: 468-473. doi: ...
... and block the cardiac dysfunction caused by extensive tissue ischemia in animal models of remote ischemic preconditioning. TP ... In addition, TP receptor antagonists lessen myocardial infarct size in various animal models of this disease ... High levels of isoprostanes form in ischemic or otherwise injured blood vessels and acting through TP, can stimulate arterial ... Aggarwal S, Randhawa PK, Singh N, Jaggi AS (2016). "Preconditioning at a distance: Involvement of endothelial vasoactive ...
Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through ... 1986) Mullane K Acadesine: the prototype adenosine regulating for reducing myocardial ischaemic injury. Cardiovasc Res 27:43-47 ... Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR Translocation of myocardial ... The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 ...
... hibernation and ischemic preconditioning". Tidsskr. Nor. Laegeforen. (in Norwegian). 121 (4): 440-4. PMID 11255859. Vaidya Y ( ... Myocardial stunning or transient post-ischemic myocardial dysfunction is a state of mechanical cardiac dysfunction that can ... Some evidence suggests that brief, repetitive episodes of myocardial ischemia may result in chronic myocardial stunning and ... Clinical situations associated with myocardial stunning include: acute myocardial infarction (AMI) with early reperfusion ...
"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning". Am ... Ischemic preconditioning (IPC) is an experimental technique for producing resistance to the loss of blood supply, and thus ... The control animals had no such period of "ischaemic preconditioning" and had much larger infarct sizes compared with the dogs ... Murry, CE; Jennings, RB; Reimer, KA (November 1986). "Preconditioning with ischemia: a delay of lethal cell injury in ischemic ...
"Remote ischemic preconditioning reduces contrast-induced acute kidney injury in patients with ST-elevation myocardial ... "Remote Ischemic Preconditioning Reduces Myocardial Injury in Patients Undergoing Coronary Stent Implantation". Canadian Journal ... "Remote Ischemic Conditioning Reduces Myocardial Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial ... The phenomenon of ischemic preconditioning (IPC) was discovered in 1986 by C. E. Murry and colleagues, who observed that ...
Fryer, R. M., Eells, J. T., Hsu, A. K., Henry, M. M., & Gross, G. J. (2000). Ischemic preconditioning in rats: role of ... Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. Circ Res 84, 973−979. ... Activation of the KATP channels on cardiac mitochondria is involved in ischemic preconditioning that results in protection for ... 50(3):552-560 Wilde, A. A. M. (1993). Role of ATP-sensitive K+ channel current in ischemic arrhythmias. Cardiovasc Drugs Ther 7 ...
Xu CF, Yu CH, Li YM (December 2009). "Regulation of hepatic microRNA expression in response to ischemic preconditioning ... Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM (February 2009). "MicroRNA-320 expression in myocardial microvascular ...
... on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced ...
... specifically in myocardial mitochondria) to survive ischemic stress conditions. This is done by adapting myocardial cells to ... This has made meldonium a possible pharmacological agent for ischemic preconditioning. The mechanisms underlying the central ... Myocardial ischemia. Mayo Clinic (25 July 2015). Retrieved on 28 May 2016. Zvejniece, L; Svalbe, B; Makrecka, M; Liepinsh, E; ... It is also used in cases of cerebral ischemia, ocular ischemic syndrome and other ocular disease caused by disturbed arterial ...
... such as during ischemic preconditioning of the heart. Although a large burst of ROS is known to lead to cell damage, a moderate ... Using a MnSOD gene silencing approach, reported that prevention of the ExTr-induced increase in myocardial MnSOD resulted in a ... can play a significant triggering role in the signal transduction pathways of ischemic preconditioning leading to reduction of ... also known as ischemic heart disease). Ischemic heart disease, which results from an occlusion of one of the major coronary ...
... such as during ischemic preconditioning of the heart. Although a large burst of ROS is known to lead to cell damage, a moderate ... Braunwald E, Kloner RA (November 1985). "Myocardial reperfusion: a double-edged sword?". The Journal of Clinical Investigation ... can play a significant triggering role in the signal transduction pathways of ischemic preconditioning leading to reduction of ... also known as ischemic heart disease). Ischemic heart disease, which results from an occlusion of one of the major coronary ...
Myocardial stunning is associated with oxidant radical damage and calcium overload. Contractile abnormalities can occur through ... Opening these channels is beneficial for post-ischemic changes in vasodilation. Other BKCa++ channel openers are reported to ... Halestrap, AP; Clarke, SJ; Khaliulin, I (2007). "The role of mitochondria in protection of the heart by preconditioning". ... It is unclear what the specific role of Akt may play in modulating of myocardial function after rottlerin treatment of ...
... before the major ischemic insult. This procedure is known as ischemic preconditioning ("IPC"), and derives its effectiveness, ... Mubagwa K, Flameng W (October 2001). "Adenosine, adenosine receptors and myocardial protection: an updated overview". ... Increased potassium conductance should stabilize membrane potential during ischemic insults, reducing the extent infarct and ...
... such as during ischemic preconditioning of the heart.[14] Although a large burst of ROS is known to lead to cell damage, a ... "Myocardial reperfusion: a double-edged sword?". The Journal of Clinical Investigation. 76 (5): 1713-9. doi:10.1172/JCI112160. ... can play a significant triggering role in the signal transduction pathways of ischemic preconditioning leading to reduction of ... also known as ischemic heart disease). Ischemic heart disease, which results from an occlusion of one of the major coronary ...
"Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass ... Heusch's research focus is on coronary blood flow and the pathophysiology of myocardial ischemia and reperfusion. He first ... In recent years, he analyzed the signal transduction of ischemic conditioning. The translation of preclinical data to clinical ... 1055-1085, doi:10.1152/physrev.1998.78.4.1055, PMID 9790569 Heusch G, Schulz R, Rahimtoola SH (2005), "Myocardial hibernation: ...
Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM, Guo S (Nov 2013). "Myocardial loss of IRS1 and ... and inhibition of p38 MAPK activity is in clinical evaluation as a potential therapy to mitigate acute injury in ischemic heart ... via phosphorylation of αβ-Crystallin or induction of Pim-3 during early response to oxidative stress or anoxic preconditioning ... Mitra A, Ray A, Datta R, Sengupta S, Sarkar S (Sep 2014). "Cardioprotective role of P38 MAPK during myocardial infarction via ...
The rapid return of myocardial blood supply is critical in order to save the ischemic heart, but it also has the potential to ... Sanada S, Komuro I, Kitakaze M (November 2011). "Pathophysiology of myocardial reperfusion injury: preconditioning, ... Myocardial damage with the resumption of blood flow after an ischemic event is termed "reperfusion injury". The mitochondrial ... "Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection". Journal of ...
Kim HW, Haider HK, Jiang S, Ashraf M (November 2009). "Ischemic preconditioning augments survival of stem cells via miR-210 ... Myocardial infarction is cardiac tissue necrosis that results from occlusion of blood supply via coronary arteries, thereby ... MiRNA-210 in particular, has been studied for its effects in rescuing cardiac function after myocardial infarcts via the up- ... Delivery of miRNA-210 to an ischemic heart improves heart function, possibly by promoting the release of angiogenic factors ...
This leads to less blood reaching the ischemic tissue, which in turn produces the characteristic chest pain. Adenosine used as ... Nakav S, Chaimovitz C, Sufaro Y (2008). Bozza P (ed.). "Anti-Inflammatory Preconditioning by Agonists of Adenosine A1 Receptor ... Adenosine is used as an adjunct to thallium (TI 201) or technetium (Tc99m) myocardial perfusion scintigraphy (nuclear stress ... The recommended dose is also reduced by half in patients presenting congestive heart failure, myocardial infarction, shock, ...
Additionally, in patients with ischemic cardiomyopathy, dilated cardiomyopathy and hypertrophic cardiomyopathy, ALC-1 protein ... "A molecular mechanism improving the contractile state in human myocardial hypertrophy". Experimental and Clinical Cardiology. 7 ... "Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1". ... ischemic cardiomyopathy and congenital heart diseases. ALC-1 is a 21.6 kDa protein composed of 197 amino acids. ALC-1 is ...
Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A, Chaitman BR, Leslie S, Stern T; Myocardial ... "all preconditions are fully met assumption", the "quantitative variable limitation" and the "placebo only or conventional ... "Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized ... it was routine for physicians to prescribe hormone replacement therapy for post-menopausal women to prevent myocardial ...
... Weiwei Wang ... Ischemic preconditioning (IPC) strongly protects against myocardial ischemia reperfusion (IR) injury. However, IPC protection ... Ischemic preconditioning (IPC) is one of the most powerful endogenous cardioprotective mechanisms [1], and it has been ... P. Abete, F. Cacciatore, G. Testa et al., "Ischemic preconditioning in the aging heart: from bench to bedside," Ageing Research ...
Experimental: Remote ischemic preconditioning Remote ischemic preconditioning performed with Blood pressure cuff insufflation ... IL-10 Levels and Remote Ischemic Preconditioning in Acute Myocardial Infarction. The safety and scientific validity of this ... Remote ischemic preconditioning has proven beneficial in patients undergoing percutaneous coronary intervention and coronary ... The investigators aim to determine whether remote ischemic preconditioning results in an increase in IL-10 levels in patients ...
Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a ... Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency ... Cardiac remote ischaemic preconditioning reduces periprocedural myocardial infarction for patients undergoing percutaneous ... Other: reported remote ischemic preconditioning (RIPC) Three five-minute cycles of upper limb ischaemia and three five-minute ...
The effect of ischemic preconditioning on nitric oxide synthase activity during myocardial ischemia and reperfusion in ... There were parallel increases in superoxide and NT production by the end of the ischemic period. PC itself enhanced NOS ... occurring during a 25 min occlusion of the left anterior descending coronary artery and following ischemic preconditioning (PC ... Methods: In 12 control and 16 preconditioned dogs, total NOS activity (measured using radioimmunoassay), superoxide (measured ...
The mechanisms involved in this phenomenon, termed ischaemic preconditioning (IPC) are still not clear, although it has … ... cardioprotection in ischaemic preconditioning in a rat model of myocardial infarction Cardiovasc J S Afr. Mar-Apr 2003;14(2):73 ... The mechanisms involved in this phenomenon, termed "ischaemic preconditioning" (IPC) are still not clear, although it has been ... of this study was to probe some of the plausible mechanisms involved in the phenomenon by using an in vivo model of myocardial ...
... improves myocardial protection in coronary artery bypass grafting (CABG) with cold-crystalloid cardioplegia and whether ... whether the late phase of remote ischaemic preconditioning (L-RIPC) ... Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing ... The purpose of this study was to test, whether the late phase of remote ischaemic preconditioning (L-RIPC) improves myocardial ...
Ishaemic preconditioning in coronary artery bypass surgery. The protective effect of ischaemic preconditioning on myocardial ... With recent unstable angina the myocardium has already been preconditioned before the operation. The IP protocol applied did ... CI after the operation was associated with myocardial FR generation during the IP protocol (p = 0.035), and negatively ... not induce additional protection to the myocardium already preconditioned by antecedent unstable angina. However, the waned IP ...
Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. Richard J. Gumina, Darko Pucar ... Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. In: American Journal of ... Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. / Gumina, Richard J.; Pucar, ... Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. American Journal of Physiology ...
... epsilon as an important cellular mediator of myocardial infarct size reduction with ischemic preconditioning (PC). Age-related ... Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phenanthridines; ... Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits ... Przyklenk, Karin; Li, Guohu; Simkhovich, Boris Z.; and Kloner, Robert A., "Mechanisms of myocardial ischemic preconditioning ...
DM stands for diabetes mellitus, IP + ischemic preconditioning present, IP - ischemic preconditioning absent, ET, exercise test ... DM stands for diabetes mellitus, IP + ischemic preconditioning present, IP - ischemic preconditioning absent, ET exercise test ... Ischemic preconditioningMyocardial ischemiaCoronary artery diseaseDiabetes mellitus. Background. According to the World Health ... manifested ischemic preconditioning (p = 0.62). The analysis of patients who demonstrated ischemic preconditioning showed ...
Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance. , Molecular and ... Among these attempts, a more convenient model of ischemic preconditioning, known as remote ischemic preconditioning (RIPC) was ... Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance. Rabia Gill Robin ... Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance. Mol Cell Biochem. 2015 ...
The effect of preconditioning (ischemic and pharmacological), cross-clamp fibrillation and cold cardioplegia on myocardial ... The effect of preconditioning (ischemic and pharmacological), cross-clamp fibrillation and cold cardioplegia on myocardial ... The effect of preconditioning (ischemic and pharmacological), cross-clamp fibrillation and cold cardioplegia on myocardial ... Cold, cardioprotection, ischemia-reperfusion, Myocardium, CABG, Cold, Ischemic, myocardial, Myocardial Necrosis, ...
Adenosine has been proved to be an important mediator of myocardial protection induced by ischemic preconditioning. The ... Myocardial Protection With Adenosine Preconditioning. The safety and scientific validity of this study is the responsibility of ... Our primary results suggested that adenosine preconditioning could decrease the release of myocardial serum markers, such as ... New progresses in myocardial protection in the settings of acute myocardial infarction treatment put forward the its clinical ...
... are major complications of ST-elevation myocardial infarction (STEMI), even in the era of reperfusion therapy. We sought to ... T1 - Role of Ischemic Preconditioning and Inflammatory Response in the Development of Malignant Ventricular Arrhythmias After ... Conclusions: Lack of ischemic preconditioning, enhanced inflammatory response, and subsequent LV dysfunction are related to the ... Conclusions: Lack of ischemic preconditioning, enhanced inflammatory response, and subsequent LV dysfunction are related to the ...
... and ion shifts in isolated ischemic/reperfused rat hearts. Together they form a unique fingerprint. * Myocardial Reperfusion ... T1 - Effects of preconditioning on reperfusion arrhythmias, myocardial functions, formation of free radicals, and ion shifts in ... Effects of preconditioning on reperfusion arrhythmias, myocardial functions, formation of free radicals, and ion shifts in ... Effects of preconditioning on reperfusion arrhythmias, myocardial functions, formation of free radicals, and ion shifts in ...
We propose that the preconditioning signalling pathway involving an amplification loop results in a downregulation of GSK-3β ... Ischemic Preconditioning, Myocardial* * Mice * Mice, Transgenic * Myocardial Infarction / enzymology * Myocardial Infarction / ... Aims: Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade ... GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways Cardiovasc Res. 2011 ...
i ,Results.,/i, In control mice, infarct size (IF) was 51.7 ± 2.0 (% risk region). Preconditioning reduced IF by 50% to 25.8 ± ... i ,Conclusion.,/i, HG abolishes the cardioprotective effect of preconditioning by inhibiting Akt phosphorylation. Normalization ... of blood glucose with insulin suffices to recover the cardioprotective effect of preconditioning. ... blocks ischemic preconditioning (IPC) by inhibiting Akt phosphorylation. Brief HG of approximately 400 mg/dL was induced in ...
... has been noted to produce ischemic preconditioning (IPC)-mediated cardioprotection. Caveolin is a negative regulator of NO, ... Effect of I-R on myocardial infarct size, effect of ischemic preconditioning (IPC) on myocardial infarct size in normal and ... However, ischemic preconditioning failed to decrease the myocardial infarct size in diabetic rat heart. Moreover, IPC induced ... Effect of ischemic preconditioning and pharmacological interventions on myocardial infarct size. Global ischemia for 30 min ...
Ischemic preconditioning (IPC) is a powerful phenomenon that provides potent cardioprotection in mammalian hearts; however, the ... Ischemic Preconditioning, Myocardial / methods*. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Myocardial Infarction / ... 15313385 - Tnf-alpha is required for late ischemic preconditioning but not for remote precondition.... 1628395 - Physiological ... Ischemic preconditioning (IPC) is a powerful phenomenon that provides potent cardioprotection in mammalian hearts; however, the ...
Remote ischemic preconditioning reduces myocardial injury in children undergoing open heart surgery ... Remote ischemic preconditioning reduces myocardial injury in children undergoing open heart surgery ... Remote ischemic preconditioning reduces myocardial injury in children undergoing open heart surgery ... Reilly Group - Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation ...
Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase. In: Molecular Medicine. 2001 ; Vol ... Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase. / Liaudet, Lucas; Yang, Zequan; Al ... Liaudet L, Yang Z, Al-Affar EB, Szabó C. Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) ... Liaudet, L, Yang, Z, Al-Affar, EB & Szabó, C 2001, Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP- ...
... administered just prior to reperfusion reduced but did not eliminate myocardial infarction in rabbits. Combining cangrelor with ... Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart. J ... Ischemic preconditioning targets the reperfusion phase. Basic Res Cardiol. 2007;102:445-52.PubMedCrossRefGoogle Scholar ... Myocardial salvage in acute myocardial infarction-challenges in clinical translation. J Mol Cell Cardiol. 2011;51:451-3.PubMed ...
Remote ischemic preconditioning and endothelial function in patients with acute myocardial infarction and primary PCI. Vladimir ... CONCLUSIONS: Remote ischemic preconditioning can reduce PCI related myocardial injury and protect vascular endothelial function ... Effects of remote ischemic preconditioning on myocardial injury and endothelial function and prognosis after percutaneous ... Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, ...
Objective Precondition is an approach to myocardial protection during ischemia-reper-fusion by inhibiting myocardial cell ... Evaluation of cardioprotective effect of ischemic preconditioning on ischemic myocardium u Evaluation of cardioprotective ... effect of ischemic preconditioning on ischemic myocardium using 99Tcm-Syt I-C2A in the myocardial ischemia-reperfusion rat ... ID/g in the ischemic myocardium,and(0.16±O.02)%ID/g in the nomud myocardiunm.However,in the myocardial ischemia precondition ...
Myocardial ischemic preconditioning and postconditioning can reduce myocardial infarct size, improve myocardial contractility, ... Animals , Humans , Ischemic Postconditioning , Methods , Ischemic Preconditioning, Myocardial , Methods , Myocardial Infarction ... Myocardial Reperfusion Injury / Signal Transduction / Myocardial Ischemia / Ischemic Preconditioning, Myocardial / Receptors, G ... Myocardial Reperfusion Injury / Signal Transduction / Myocardial Ischemia / Ischemic Preconditioning, Myocardial / Receptors, G ...
... administered 50 min after ischemic preconditioning, totally abolished preconditioning-induced reductions in myocardial infarct ... Isoflurane Mimics Ischemic Preconditioning via Activation of KATPChannels : Reduction of Myocardial Infarct Size with An Acute ... Isoflurane Mimics Ischemic Preconditioning via Activation of KATPChannels : Reduction of Myocardial Infarct Size with An Acute ... ischemic preconditioning, 34.6 +/- 2.1; isoflurane, 34.2 +/- 1.4; isoflurane before and during ischemic preconditioning, 32.0 ...
Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning. Circulation ... Improved functional recovery by ischemic preconditioning is not mediated by adenosine in the globally ischemic isolated rat ... Sack S, Mohri M, Arras M, Schwarz ER, Schaper W (1993) Ischemic preconditioning-time course of renewal in the pig. Cardiovasc ... Vahlhaus C, Schulz R, Post H, Onallah R, Heusch G (1996) No prevention of ischemic preconditioning by the protein kinase C ...
Remote ischemic preconditioning in myocardial protection in hemodialysis patients Bacci MR, Vasconcelos LY, Murad N, Chagas AC ...
rIPC [remote IPC (ischaemic preconditioning)] has been shown to invoke potent myocardial protection in animal studies and ... remote ischaemic preconditioning. Abbreviations: AMPK, AMP-activated protein kinase; CFR, coronary flow rate; dP/dtmax, maximum ... ischaemic preconditioning; IR, ischaemia/reperfusion; KHB, Krebs-Henseleit buffer; LV, left ventricular; LVDP, LV developed ... Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of ...
Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion. * ... Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular ...
  • The purpose of this study was to test, whether the late phase of remote ischaemic preconditioning (L-RIPC) improves myocardial protection in coronary artery bypass grafting (CABG) with cold-crystalloid cardioplegia and whether preoperative tramadol modifies myocardial ischaemia-reperfusion injury using the same group of patients in a single-blinded randomized controlled study. (biomedsearch.com)
  • There has been a continued search for better cardioprotective modalities that would reduce myocardial ischemia-reperfusion injury. (docphin.com)
  • Ischemic preconditioning is a powerful endogenous protective mechanism against myocardial ischemia/reperfusion injury, which is induced by brief episodes of ischemia and reperfusion before the prolonged index myocardial ischemia and reperfusion [ 9 ]. (hindawi.com)
  • It is also well known that insulin exerts a salutary preconditioning effect against myocardial ischemia/reperfusion injury [ 13 , 14 ]. (hindawi.com)
  • It is now well known that activation of adenosine A 1 receptors (A 1 R), either by ischemic preconditioning or by specific agonists, triggers the protective effect against myocardial ischemia/reperfusion injury [ 18 - 24 ]. (hindawi.com)
  • In conclusion, IPC protects WT mice against in vivo myocardial ischemia-reperfusion injury regardless of sex and ischemic duration, but the deletion of eNOS abolishes the cardioprotective effect of classical IPC. (biomedsearch.com)
  • Results: Both poly(ADP-ribose) synthetase (PARS) deficiency and ischemic preconditioning (IPC) induced protection from reperfusion injury, attenuated inflammatory mediator production, and reduced neutrophil infiltration when compared to the response in wild-type mice. (utmb.edu)
  • The protection against reperfusion injury by IPC was also associated with partially preserved myocardial NAD + levels, indicating that PARS activation is attenuated by IPC. (utmb.edu)
  • This paper reviewed about ischemic preconditioning and postconditioning protection mechanisms in myocardial ischemia reperfusion injury and clinical research literatures in recent years, to provide a theoretical basis for finding new treatment strategies on the prevention and treatment of ischemic cardiomyopathy . (bvsalud.org)
  • Introduction The Reperfusion Injury Salvage Kinase (RISK) pathway is the term given to prosurvival kinases such as the phosphatidylinositol-3 kinase (PI3K)-Akt cascade, which confer cardioprotection when specifically activated at the onset of myocardial reperfusion following an infarct. (bmj.com)
  • The impact of diabetes on myocardial ischemia-reperfusion injury has been the focus of numerous animal studies. (ahajournals.org)
  • IPC (ischaemic preconditioning) may protect the steatotic liver, which is particularly susceptible to I/R (ischaemia/reperfusion) injury. (portlandpress.com)
  • Protective effect of celastrol on myocardial ischemia-reperfusion injury. (bioportfolio.com)
  • BACKGROUND Diosgenin, a phytosteroid sapogenin, has anti-inflammatory properties shown to reduce myocardial ischemia-reperfusion injury (MIRI). (bioportfolio.com)
  • However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY. (bioportfolio.com)
  • Ischemia reperfusion injury (IR injury) associated with ischemic heart disease contributes significantly to morbidity and mortality. (mdpi.com)
  • Introduction Remote ischaemic preconditioning (RIPC) using brief cycles of upper or lower limb ischaemia and reperfusion has been reported to protect the heart against ischaemia-reperfusion injury (IRI). (bmj.com)
  • Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice. (semanticscholar.org)
  • The protective effect of fasudil pretreatment combined with ischemia postconditioning on myocardial ischemia/reperfusion injury in rats. (semanticscholar.org)
  • However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. (jci.org)
  • A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI. (jci.org)
  • The effects of CHD are usually attributable to the detrimental effects of acute myocardial ischemia-reperfusion injury (IRI). (jci.org)
  • Although the process of myocardial reperfusion continues to improve with more timely and effective reperfusion and with advances in PCI technology and antiplatelet and antithrombotic agents for maintaining the patency of the infarct-related coronary artery, there is still no effective therapy for preventing myocardial reperfusion injury. (jci.org)
  • In this respect, myocardial reperfusion injury remains a neglected therapeutic target for cardioprotection in PPCI patients. (jci.org)
  • The notion of lethal reperfusion injury in the heart implies that injury ensues to viable myocytes at the time of reperfusion, over and above, the cellular damage normally attributed to the initial ischemic event. (omicsonline.org)
  • Various forms of reperfusion injury can include myocardial and vascular stunning, microvascular injury and no-reflow, arrhythmias, etc. (omicsonline.org)
  • articles concerning reperfusion injury (lethal and otherwise), ischemia-reperfusion injury, apoptosis, microvascular injury, ischemic conditioning and different combinations thereof were consulted. (omicsonline.org)
  • Brief episodes of ischemia at a distant organ could reduce the myocardial reperfusion injury. (springer.com)
  • Ischemia/reperfusion injury in male guinea pigs: An efficient model to investigate myocardial damage in cardiovascular complications. (abcam.com)
  • Norepinephrine (NE)-derived free radicals may contribute to myocyte injury after ischemia -reperfusion, so the influence of sympathetic denervation on myocardial ischemia - reperfusion injury was investigated in the present study. (nii.ac.jp)
  • Time to take myocardial reperfusion injury seriously. (duke-nus.edu.sg)
  • Extensive research over the past decade has alluded to the cellular mechanisms underlying this powerful means of reducing myocardial ischemia-reperfusion injury. (ucl.ac.uk)
  • Reduction of myocardial reperfusion injury by high-dose beta-blockade with esmolol. (eurekaselect.com)
  • Myocardial ischemia/reperfusion injury occurs in a wide spectrum of patients, ranging from survivors of out-of-hospital cardiac arrest to AMI victims and patients undergoing cardiac surgery, and represents a major public health burden. (ahajournals.org)
  • The goal of thrombolytic therapy in patients with acute ischemic stroke is early recanalization, but this may result in delayed reperfusion injury. (ajnr.org)
  • 10 Thus, reperfusion hyperemia can save the ischemic tissue by rapid restoration of the cerebral blood flow, but delayed reperfusion injury may occur because of the presence of oxidants or free radical damage. (ajnr.org)
  • With recent unstable angina the myocardium has already been preconditioned before the operation. (uta.fi)
  • The IP protocol applied did not induce additional protection to the myocardium already preconditioned by antecedent unstable angina. (uta.fi)
  • In contrast with WT hearts, preconditioning failed to preserve contractile recovery in Kir6.2-KO hearts, as tight coupling between postischemic performance and high-energy phosphoryl transfer was compromised in the K ATP -channel-deficient myocardium. (elsevier.com)
  • Yellon DM, Alkhulaifi AM, Pugsley WB (1993) Preconditioning the human myocardium. (springer.com)
  • 5,10-14 ] Ischemic preconditioning also is characterized by an acute memory phase, during which time myocardium remains resistant to infarction for up to 2 h after the preconditioning stimulus. (asahq.org)
  • 15 ] Isoflurane, similarly to ischemic preconditioning, has recently been shown to modulate cardioprotective signal transduction in stunned myocardium. (asahq.org)
  • 16-18 ] The present investigation tested the hypothesis that isoflurane directly preconditions myocardium against myocardial infarction via activation of K ATP channels and that this effect is associated with an acute memory phase, thus mimicking ischemic preconditioning. (asahq.org)
  • Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. (bioportfolio.com)
  • Myocardial stunning or transient post-ischemic myocardial dysfunction is a state of mechanical cardiac dysfunction that can occur in a portion of myocardium without necrosis after a brief interruption in perfusion, despite the timely restoration of normal coronary blood flow. (wikipedia.org)
  • Clinical situations associated with myocardial stunning include: acute myocardial infarction (AMI) with early reperfusion unstable angina after percutaneous transluminal coronary angioplasty (PTCA) after cardiac surgery 'neurogenic' stunned myocardium following an acute cerebrovascular event such as a subarachnoid hemorrhage in patients undergoing chronic hemodialysis, chronic myocardial stunning may lead to heart failure Myocardial stunning has been implicated in the development of Takotsubo (Stress) cardiomyopathy. (wikipedia.org)
  • The diagnosis of myocardial stunning must also be differentiated from other conditions such as hibernating myocardium and persistent (silent) subendocardial ischemia, which can also co-exist with superimposed stunning. (wikipedia.org)
  • 1987. α 1 -Adrenoceptor activity regulates release of adenosine from the ischemic myocardium in dogs. (springer.com)
  • However, the kinetics of GLP-1R expression in the infarcted/ischemic myocardium has not yet been explored. (snmjournals.org)
  • The specificity of tracer uptake into ischemic myocardium was supported by decreased tracer uptake after the rats were pretreated with an excess amount of unlabeled exendin-4. (snmjournals.org)
  • Protection of the ischemic myocardium during the reperfusion: between hope and reality. (semanticscholar.org)
  • Ischemic preconditioning reduces infarct size in swine myocardium. (semanticscholar.org)
  • Acute occlusion of the coronary artery in the STEMI patient subjects the myocardium supplied by that vessel to acute myocardial ischemia, thereby demarcating the area at risk (AAR) of potential MI, should the acute coronary occlusion be sustained or permanent. (jci.org)
  • In the heart, IPC is an intrinsic process whereby repeated short episodes of ischaemia protect the myocardium against a subsequent ischaemic insult. (wikipedia.org)
  • Detailed analyses of regional myocardial blood flow, function, metabolism and morphology in ischemic and reperfused myocardium have led to the identifi- cation of important phenomena, i. e. , myocardial hibernation, myocardial stun- ning and ischemic preconditioning. (foyles.co.uk)
  • It has been reported that intramyocardial stem cell transplantation can notably increase the perfusion of blood in ischemic myocardium and improve heart functions [ 1 , 2 ]. (omicsonline.org)
  • Over the past two decades, it has been demonstrated in various animal species that the myocardium possesses innate adaptive mechanisms that may render it more resistant to ischemic injury. (ucl.ac.uk)
  • Ischemic preconditioning, defined as the protection conferred to ischemic myocardium by prior episodes of brief sublethal ischemia, is one of the most potent of such adaptive phenomena. (ucl.ac.uk)
  • Data obtained from adult cohorts have implicated activation/translocation of protein kinase C (PKC)-epsilon as an important cellular mediator of myocardial infarct size reduction with ischemic preconditioning (PC). (umassmed.edu)
  • A substantial effort has been put forth to investigate any promising cardioprotective strategy to effectively reduce myocardial infarct size. (biomedcentral.com)
  • An increasing body of clinical evidence has shown that acute hyperglycemia (or stress hyperglycemia) is independently associated with larger myocardial infarct (MI) size and impaired left ventricular function in both diabetic and nondiabetic patients [ 4 - 6 ]. (hindawi.com)
  • Therefore, we performed extensive experiments in wild-type (WT) and eNOS knockout (eNOS(-/-)) mice to evaluate whether the infarct-limiting effect of IPC depends on eNOS, ischemic periods, and sex. (biomedsearch.com)
  • Protection was evaluated by measuring the myocardial infarct size as a percentage of the area at risk. (biomedsearch.com)
  • Myocardial ischemic preconditioning and postconditioning can reduce myocardial infarct size, improve myocardial contractility, protect coronary endothelial and myocardial cell ultrastructure , as well as reduce the incidence of arrhythmias. (bvsalud.org)
  • RIPost) can reduce myocardial infarct size. (bmj.com)
  • We hypothesised that RIPC and RIPost limit myocardial infarct size through activation of the RISK pathway. (bmj.com)
  • Methods Mini swine (25-30 kg) were subjected to in situ left anterior descending (LAD) coronary artery ischaemia (60 min) followed by myocardial reperfusion (180 min) at the end of which myocardial infarct size was determined using tetrazolium staining. (bmj.com)
  • Conclusion Remote ischaemic preconditioning using lower limb ischaemia reduces myocardial infarct size by activating the PI3K-Akt component of the RISK pathway. (bmj.com)
  • Reperfusion function and myocardial infarct size were used as endpoints. (ovid.com)
  • Preconditioning the eNOS overexpressed hearts resulted in infarct sizes comparable with control non-preconditioned hearts (27.5 ± 2.0% vs. 26.9 ± 1.4% for controls). (ovid.com)
  • In conclusion, the impairment in contractile function despite the reduction in infarct size underscores the increased susceptibility of the hypertrophied, hypertensive heart to ischemic injury. (ahajournals.org)
  • Restoration of blood flow to the ischemic area is the most important component for reduction of infarct size. (mdpi.com)
  • Studies using adrenoceptor blockers have reponed very contradictory results and do not allow us to draw a clear conclusion about the role of adrenoceptors in infarct size limitation by preconditioning. (springer.com)
  • Dipyridamole potentiates the myocardial infarct size-limiting effect of preconditioning. (springer.com)
  • 1994. α 1 -Adrenoceptor activation mediates the infarct size-limiting effect of ischemic preconditioning through augmentation of 5′-nucleotidase activity. (springer.com)
  • The control animals had no such period of "ischaemic preconditioning" and had much larger infarct sizes compared with the dogs that did. (wikipedia.org)
  • Such injury would occur when a patient has an acute myocardial infarct followed by reperfusion by either percutaneous coronary intervention or thrombolysis. (wikipedia.org)
  • Burns RJ, Gibbons RJ, Yi Q, Roberts RS, Miller TD, Schaer GL, Anderson JL, Yusuf S, Investigators CS (2002) The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. (springer.com)
  • Ischemic preconditioning is the most powerful maneuver known so far to delay infarct development. (foyles.co.uk)
  • Yellon, Derek 2018-06-01 00:00:00 Remote ischaemic conditioning (RIC) is a promising method of cardioprotection, with numerous clinical studies having demonstrated its ability to reduce myocardial infarct size and improve prognosis. (deepdyve.com)
  • In particular, experimental studies have demonstrated that it is able to reduce infarct size in an acute ischaemic stroke model. (deepdyve.com)
  • 106]. They demonstrated in a canine model that a in a rat model that remote ischaemic conditioning (RIC) series of brief, alternating episodes of ischaemia and reper- could be applied to a limb during myocardial ischaemia, and fusion, applied to one area of the left ventricle (LV) myocar- reduce infarct size by 50% [77]. (deepdyve.com)
  • 94] achieved a similar infarct- simultaneously with the onset of myocardial reperfusion- limiting effect in rabbits by applying a single 10-min episode a phenomenon named as remote ischaemic postcondition- of ischaemia to a kidney prior to 30-min occlusion of the ing (RIPost) [1]. (deepdyve.com)
  • However, since the demonstrated in a rat model of acute myocardial infarction RIPre stimulus must, by definition, be applied before the that RIPost applied after a 10-min delay following the onset onset of ischaemia, it is clear that the only possible clinical of reperfusion was still able to reduce infarct size similarly niche for the RIPre phenomenon in cardioprotection could to RIPre [5]. (deepdyve.com)
  • Surprisingly, in the absence of IPC, pretreatment with CPX or BG 9928 before occlusion or immediately before reperfusion resulted in significant reductions (∼40-50%) in myocardial infarct size. (aspetjournals.org)
  • The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction. (amedeo.com)
  • Nitric oxide (NO) has been noted to produce ischemic preconditioning (IPC)-mediated cardioprotection. (biomedcentral.com)
  • Obestatin affords cardioprotection to the ischemic/reperfused isolated rat heart and inhibits apopto. (biomedsearch.com)
  • Is it time to translate ischemic preconditioning's mechanism of cardioprotection into clinical practice? (springer.com)
  • Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis. (springer.com)
  • This is called remote ischemic preconditioning (RIPC) cardioprotection. (springer.com)
  • Preinfarction angina, a form of chest pain, is associated with significant cardioprotection in myocardial infarction patients. (springer.com)
  • Keywords Remote ischaemic conditioning · Cardioprotection · Neuroprotection Introduction percutaneous coronary intervention (PCI)-scenarios when the onset and the duration of ischaemia are carefully con- It is almost 25 years since the phenomenon of remote ischae- trolled (Fig. 1). (deepdyve.com)
  • However, determination of AAR by MRI' may not be accurate, since MRI-indices of microvascular damage, i.e., myocardial edema and microvascular obstruction (MVO), may be affected by cardioprotection independently from myocardial necrosis. (uzh.ch)
  • Pre-clinical and clinical cardiac MRI and hybrid PET/MR studies to investigate the pathophysiology of acute IRI and assess cardioprotection in the setting of AMI and post-ischaemic heart failure. (duke-nus.edu.sg)
  • Cardioprotection in the preconditioning era. (ucl.ac.uk)
  • Conclusion: These results confirm earlier studies on esmolol-cardioprotection from myocardial IR-injury and demonstrate that a dose optimized epinephrine-esmolol co-treatment maintains esmolol-cardioprotection with improved hemodynamics compared to esmolol treatment alone. (eurekaselect.com)
  • The Working Group concluded that cardioprotection in the setting of acute myocardial infarction, cardiac surgery, and cardiac arrest is at a crossroads. (ahajournals.org)
  • Second, MG53 is essentially involved in the cardioprotection of cardiac ischemic, preconditioning, and postconditioning by activating the PI3K-Akt-GSK3 β and ERK1/2 survival signaling pathways. (aspetjournals.org)
  • abstract = "Although ischemic preconditioning induces bioenergetic tolerance and thereby remodels energy metabolism that is crucial for postischemic recovery of the heart, the molecular components associated with preservation of cellular energy production, transfer, and utilization are not fully understood. (elsevier.com)
  • 1996, Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits (abstract). (springer.com)
  • The patients were studied twice, with or without ischemic preconditioning (10 minutes of forearm ischemia and reperfusion). (springermedizin.de)
  • Glucagonlike peptide (GLP-1) and its receptor (GLP-1R) exhibit cardioprotective effects after myocardial ischemia and reperfusion (MI/R) in both animal studies and clinical trials. (snmjournals.org)
  • Based on these findings, we hypothesized that esmololepinephrine combination therapy would be superior to a reported cardioprotective esmolol therapy alone in a mouse model of myocardial ischemia and reperfusion (IR) injury. (eurekaselect.com)
  • 13) Other studies have demonstrated that RIPC using brief ischemia and reperfusion of the upper limb could reduce myocardial injury in adult patients undergoing CABG surgery. (thefreedictionary.com)
  • Remote ischemic preconditioning has proven beneficial in patients undergoing percutaneous coronary intervention and coronary artery bypass surgery. (clinicaltrials.gov)
  • Ishaemic preconditioning in coronary artery bypass surgery. (uta.fi)
  • In this situation, even after ischemia has been relieved (by for instance angioplasty or coronary artery bypass surgery) and myocardial blood flow (MBF) returns to normal, myocardial function is still depressed for a variable period of time, usually days to weeks. (wikipedia.org)
  • It was reported remote ischemic preconditioning (RIPC) may play an effective endogenous cardiac protection. (clinicaltrials.gov)
  • We found that L-RIPC can reduce injury beyond the myocardial protection provided by cold-crystalloid cardioplegia, and tramadol worsened myocardial injury after CABG. (biomedsearch.com)
  • Among these attempts, a more convenient model of ischemic preconditioning, known as remote ischemic preconditioning (RIPC) was first introduced in 1993 by Przyklenk and colleagues who reported that brief regional occlusion-reperfusion episodes in one vascular bed of the heart render protection to remote myocardial tissue. (docphin.com)
  • Subsequently, major advances in myocardial RIPC came with the use of skeletal muscle as the ischemic stimulus. (docphin.com)
  • This study assessed the protective effect of remote ischemic preconditioning (RIPC) in patients undergoing successful drug-eluting stent implantation with normal baseline troponin values. (qxmd.com)
  • rIPC [remote IPC (ischaemic preconditioning)] has been shown to invoke potent myocardial protection in animal studies and recent clinical trials. (clinsci.org)
  • We therefore examined the hypothesis that the myocardial protection afforded by rIPC is mediated via the PI3K/Akt/GSK3β (glycogen synthase kinase 3β) signalling pathway, activation of which is associated with nuclear accumulation of β-catenin. (clinsci.org)
  • In conclusion, we show for the first time that the myocardial protection afforded by rIPC is mediated via the PI3K/Akt/GSK3β signalling pathway, activation of which is associated with nuclear accumulation of β-catenin and the up-regulation of its downstream targets E-cadherin and PPARδ involved in cell survival. (clinsci.org)
  • Remote ischemic preconditioning (RIPC) may confer the protection in critical organs. (asahq.org)
  • The purpose of this study is to determine whether Glyceryl Trinitrate (GTN) reduces injury to the heart during heart-lung bypass surgery in combination with the newer technique of remote ischaemic preconditioning (RIPC). (clinicaltrials.gov)
  • Remote ischaemic preconditioning (RIPC) has been shown to reduce perioperative myocardial injury (PMI) in patients having CABG even when cold blood cardioplegia or intermittent cross clamp fibrillation is used as cardioprotective measures. (clinicaltrials.gov)
  • Short-term ischemia leads to vasodilatation and reactive hyperemia resulting in post-ischemic reperfus. (bioportfolio.com)
  • Recently, post-ischemic left ventricular (LV) diastolic stunning is shown to persist for more than 24 hours despite complete systolic functional recovery. (ahajournals.org)
  • Considering that limited data are available for preconditioning effect in human beings, we sought to examine whether preconditioning may protect post-ischemic diastolic stunning during percutaneous coronary intervention (PCI) in patients with coronary artery disease. (ahajournals.org)
  • This suggests that preconditioning protects post-ischemic diastolic stunning after PCI. (ahajournals.org)
  • Increasing experimental and clinical findings indicate that aberrant function of these regulatory mechanisms promotes the evolution of cardiac disorders such as post-ischemic injury, pathological hypertrophy, and heart failure, which may be reversed by the correction of the underlying TH dyshomeostasis. (frontiersin.org)
  • Pathogenesis of post-ischemic cellular injury is discussed along with potential interventions (pharmacologic and non-pharmacologic) currently being used to improve clinical outcomes. (omicsonline.org)
  • Ischemic parameters were compared among patients with and without type 2 diabetes mellitus. (biomedcentral.com)
  • Systemic hypertension and type 2 diabetes mellitus are major risk factors for myocardial infarction. (ahajournals.org)
  • Some of the major challenges are in response to myocardial ischemia and when compounded by complications arising from Type 2 Diabetes Mellitus. (edu.au)
  • Myocardial necrosis occurs frequently in elective percutaneous coronary intervention (PCI) and is associated with subsequent major adverse cardiovascular events (MACEs). (qxmd.com)
  • Effect of remote ischemic preconditioning on serum troponin T level following elective percutaneous coronary intervention. (qxmd.com)
  • Effect of one-cycle remote ischemic preconditioning to reduce myocardial injury during percutaneous coronary intervention. (qxmd.com)
  • Remote ischemic preconditioning improves outcome at 6 years after elective percutaneous coronary intervention: the CRISP stent trial long-term follow-up. (qxmd.com)
  • Late remote ischemic preconditioning provides benefit to patients undergoing elective percutaneous coronary intervention. (qxmd.com)
  • Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results from the ARMYDA-6 MI (Antiplatelet therapy for Reducton of MYocardial Damage during Angioplasty-Myocardial Infarction) randomized study. (springer.com)
  • To explore the effects of remote ischemic preconditioning on myocardial injury and prognosis after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. (qxmd.com)
  • Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: a single center randomized sham controlled trial. (qxmd.com)
  • The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention. (qxmd.com)
  • In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). (jci.org)
  • IRI typically arises in patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), in whom the most effective therapeutic intervention for reducing acute myocardial ischemic injury and limiting the size of myocardial infarction (MI) is timely and effective myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI). (jci.org)
  • Unstable angina pectoris prior to ST elevation myocardial infarction in patients treated with primary percutaneous coronary intervention has no influence on prognosis. (muni.cz)
  • The aim of this study was to compare short and long term outcomes in patients with or without pre-infarction UAP and ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). (muni.cz)
  • In a variable proportion of patients presenting with ST-segment elevation myocardial infarction, ranging from 5% to 50%, primary percutaneous coronary intervention achieves epicardial coronary artery reperfusion but not myocardial reperfusion, a condition known as no-reflow. (onlinejacc.org)
  • Prompt referral for mechanical reperfusion by urgent primary percutaneous coronary intervention (PPCI) represents the pivotal step in the current management of ST-segment elevation myocardial infarction (STEMI) ( 1 ). (onlinejacc.org)
  • Estimate of the number of patients (pts) receiving optimal reperfusion according to Thrombolysis In Myocardial Infarction (TIMI) flow grade, myocardial blush grade (MBG), and ST-segment resolution (STR) of 100 patients without cardiogenic shock treated by primary percutaneous coronary intervention (PPCI). (onlinejacc.org)
  • Prognostic impact of alkaline phosphatase measured at time of presentation in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. (amedeo.com)
  • Adenosine has been proved to be an important mediator of myocardial protection induced by ischemic preconditioning. (clinicaltrials.gov)
  • The hypothesis of this study is that adenosine preconditioning can provide additional myocardial protection in the setting of pediatric open heart surgery with cardioplegia and cardiopulmonary bypass. (clinicaltrials.gov)
  • Our primary results suggested that adenosine preconditioning could decrease the release of myocardial serum markers, such as cTnI. (clinicaltrials.gov)
  • This study will focus on the safety and effectiveness of adenosine in the field of pediatric myocardial protection during surgery repair of congenital heart defects with CPB and cardioplegia. (clinicaltrials.gov)
  • Baxter GF, Marber MS, Patel VC, Yellon DM (1994) Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning. (springer.com)
  • Cave AC, Collis CS, Downey JM, Hearse DJ (1993) Improved functional recovery by ischemic preconditioning is not mediated by adenosine in the globally ischemic isolated rat heart. (springer.com)
  • Iliodromitis EK, Miki T, Downey JM, Kremastinos D Th (1997) PKC is downstream of adenosine receptors in ischemic preconditioning. (springer.com)
  • 1991) Protection against infarction afforded by preconditioning is mediated by Al adenosine receptors in rabbit heart. (springer.com)
  • Contribution of Endogenous Catecholamines to Preconditioning: Is it through Facilitation of Adenosine Production? (springer.com)
  • Our findings using microdialysis suggest that the role of catecholamines in preconditioning is not through modulating production of adenosine, a key trigger of the preconditioning mechanism. (springer.com)
  • The role of adenosine in ischemic preconditioning. (springer.com)
  • 1994. Evidence that the adenosine A 3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart. (springer.com)
  • 1993. Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation. (springer.com)
  • Cardiac adenosine production is linked to myocardial PO 2 . (springer.com)
  • Catecholamines can induce adenosine receptor-mediated protection of the myacardium but do not participate in ischemic preconditioning in the rabbit. (springer.com)
  • Myocardial protective effects of adenosine. (semanticscholar.org)
  • Is thought to be stimulated by local action of adenosine, opiates and bradykinin which are all endogenously released by ischemic cells. (wikipedia.org)
  • Their specific recommendations include the establishment of a preclinical consortium and the performance of 2 clinical studies that are likely to demonstrate effectiveness (phase III clinical trials of adenosine in acute myocardial infarction and cardiac surgery). (ahajournals.org)
  • Nonetheless, it is generally found that the ischemic heart from the mildly diabetic animal resists the accumulation of calcium, a major cause of necrosis. (ahajournals.org)
  • Background) Ischemic preconditioning has been demonstrated in animal models to significantly reduce the extent of myocardial necrosis. (ahajournals.org)
  • However, a series of studies demon- Department of Cardiology, Karolinska University Hospital, strated implication of non-mPTP/necrosis mechanisms in 171 76 Stockholm, Sweden Vol.:(0123456789) 1 3 25 Page 2 of 15 Basic Research in Cardiology (2018) 113:25 Fig. 1 Schematic time lines representing the concepts of remote ischaemic pre-, per-, post- and delayed postcondition- ing, and the clinical scenarios in which they may be relevant. (deepdyve.com)
  • positive control) on myocardial necrosis, edema and MVO in a clinically relevant, closed-chest pig model of AMI. (uzh.ch)
  • IPostC (6 × 30 s ischemia/reperfusion after 90-min occlusion) and RIC (4 × 5 min hind limb ischemia/reperfusion during 90-min LAD occlusion) did not reduce myocardial necrosis as assessed by late gadolinium enhancement 3 days after reperfusion and by ex vivo triphenyltetrazolium chloride staining 3 h after reperfusion, however, the positive control, IPreC (3 × 5 min ischemia/reperfusion before 90-min LAD occlusion) did. (uzh.ch)
  • CONCLUSION: We conclude that IPostC and RIC interventions may protect the coronary microvasculature even without reducing myocardial necrosis. (uzh.ch)
  • Ischemic preconditioning (IPC) strongly protects against myocardial ischemia reperfusion (IR) injury. (hindawi.com)
  • Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial. (biomedsearch.com)
  • The effect of remote ischaemic preconditioning on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery. (qxmd.com)
  • Surprisingly, the protective effect of IPC not only disappeared in PARS -/ mice, but the degree of myocardial injury and inflammatory response was similar to the one seen in wild-type animals. (utmb.edu)
  • Remote ischemic preconditioning can reduce PCI related myocardial injury and protect vascular endothelial function. (qxmd.com)
  • However, as discussed by Feuvray and Lopaschuk 3 and Paulson, 4 there has been considerable debate regarding the sensitivity of the diabetic heart to ischemic injury. (ahajournals.org)
  • 3 On the other hand, the severely diabetic heart is more susceptible to ischemic injury because of enhanced oxidative stress and eicosanoid-mediated injury, the accumulation of undesirable metabolic products, vascular dysfunction, and the impairment in glycolytic ATP generation. (ahajournals.org)
  • A number of pathogenic mechanisms could cause the aggravation of ischemic injury by the superimposition of hypertension on type 2 diabetes. (ahajournals.org)
  • Diosgenin Protects Rats from Myocardial Inflammatory Injury Induced by Ischemia-Reperfusion. (bioportfolio.com)
  • Ischemic or pharmacological preconditioning are powerful interventions to reduce ischemia reperfusion (IR)-injury. (springermedizin.de)
  • IR-injury was induced by unilateral forearm ischemic exercise. (springermedizin.de)
  • The efficacy of ischemic preconditioning to reduce IR-injury, however, was lower in the patients and was even completely abolished during hyperglycemia. (springermedizin.de)
  • The efficacy of ischemic preconditioning to limit IR-injury, however, is reduced by acute hyperglycemia. (springermedizin.de)
  • Experimental cellular and animal models, and also human studies, have demonstrated that protection against IR injury by ischemic preconditioning, and the more clinically applicable remote ischemic preconditioning, is associated with increases in O-GlcNAc levels. (mdpi.com)
  • From the authors: "These data show that while chronic cardiac injury following [myocardial infarction] protected against acute kidney injury via activation of hypoxia-sensing pathways, it worsened chronic kidney injury. (newswise.com)
  • NMN protected the heart from I/R injury when it was applied once 30 minutes before ischemia or 4 times just before and during reperfusion, suggesting that exogenous NMN protects the heart from I/R injury in both ischemic and reperfusion phases. (nih.gov)
  • A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP-II) and comparing to a control. (freepatentsonline.com)
  • An increase of EMAP-II indicates the presence of traumatic brain injury and a decrease of EMAP-II indicates the presence of ischemic brain injury. (freepatentsonline.com)
  • comparing said level to EMAP-II and/or p43 EMAP-II in a control, said control comprising a patient that has no brain injury, wherein if there is an increase in the level relative to the control, there is the presence of traumatic brain injury and if there is a decrease in the level relative to the control, there is ischemic brain injury. (freepatentsonline.com)
  • 2. The method of claim 1, wherein the increase is 1.6 to 1.8 fold relative to the control for traumatic brain injury and the decrease is 2.1 to 2.3 fold relative to the control for ischemic brain injury. (freepatentsonline.com)
  • HDACs have recently been shown to be involved in ischemic injury in the brain 6 , 7 and heart. (asnjournals.org)
  • Our data suggest that ATF3 contributes to the negative regulation of inflammatory cytokine gene expression by recruiting HDAC1 to ATF/NF-κB-binding sites and curtails the production of inflammatory cytokine genes, thereby preventing damaging inflammatory responses after ischemic renal I/R injury. (asnjournals.org)
  • Since the original descriptions of the role of stromal cell-derived factor (SDF)-1 in recruiting bone marrow derived stem cells to the sites of vascular 1 and myocardial injury, 2 there has been increasing evidence of the broader importance of the SDF-1:CXCR4 axis in regulating myocardial repair following ischemic injury. (ahajournals.org)
  • Fig. 6: Lysine acetylation in cardiomyocyte apoptosis, diabetic cardiomyopathy and myocardial IR injury. (nature.com)
  • Zhu, Protective effect of ocotillol on acute myocardial injury induced by lad in rat, J Mol Cell Cardiol. (thefreedictionary.com)
  • Withholding angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) 24 hours before noncardiac surgery has been associated with a 30-day lower risk for all-cause death, stroke, myocardial injury , and intra operative hypotension (18% adjusted relative risk reduction). (thefreedictionary.com)
  • While some authors advocate blood transfusion in severely anemic patients with myocardial injury , (1) red blood cell (RBC) transfusion in cardiac surgery was shown to be associated with increased morbidity and mortality. (thefreedictionary.com)
  • MUNICH -- The worldwide cardiology community's newly revised universal definition of an MI refines the way that cardiologists distinguish between myocardial infarction and myocardial injury , said Joseph S. (thefreedictionary.com)
  • If there is an abnormal rhythm on ECG and suspected myocardial injury , 24-hour monitoring, serial physical examinations, and cardiac enzymes levels follow-up are suggested (11). (thefreedictionary.com)
  • Cisplatin is the backbone of GCT chemotherapy, and is related to myocardial injury , thromboembolism and vasculitis. (thefreedictionary.com)
  • Myocardial injury , major bleeding, and sepsis contributed to nearly three-quarters of all deaths. (thefreedictionary.com)
  • For example, endogenous SO[sub]2 was found to prevent the isopropanol-induced myocardial injury , acting as an antioxidant and a protector against the mitochondrial dysfunction. (thefreedictionary.com)
  • Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function. (amedeo.com)
  • Peri-procedural myocardial injury in PCI? (hospitalhealthcare.com)
  • In non-STEMI ACS there is usually transient vessel occlusion, with lesser myocardial injury. (hospitalhealthcare.com)
  • Complex elective coronary intervention for stable disease, however, is also necessarily associated with some degree of myocardial injury. (hospitalhealthcare.com)
  • The mechanisms of myocardial injury in ACS are related to the underlying pathology, but the PCI itself is more complex due to the presence of thrombus and recent myocardial injury and the PCI procedure itself can also exaggerate injury due to loss of small side branches of distal propagation of plaque material. (hospitalhealthcare.com)
  • Furthermore, Milani and colleagues(9) have demonstrated that any detectable troponin release following PCI is predictive of myocardial injury and the incidence of death. (hospitalhealthcare.com)
  • Measurement of troponin is a very sensitive method to detect myocardial injury. (hospitalhealthcare.com)
  • The situation is made more complicated by the fact, that in high-risk ACS patients, a small amount of myocardial injury related to the PCI may confer longer-term advantages which may not be the case in those at low-risk (for example, stable) patient. (hospitalhealthcare.com)
  • Despite these issues, the new universal definition of myocardial infarction defines PCI-related MI as five-times the upper reference limit, and minimising the extent of injury would seem to be beneficial. (hospitalhealthcare.com)
  • The investigators aim to determine whether remote ischemic preconditioning results in an increase in IL-10 levels in patients following acute myocardial infarction. (clinicaltrials.gov)
  • Patients with acute myocardial infarction (AMI) are in critical condition especially without emergency reperfusion therapy. (clinicaltrials.gov)
  • CI after the operation was associated with myocardial FR generation during the IP protocol (p = 0.035), and negatively associated with age and lactate production during the protocol in IP patients (p = 0.002 and 0.026). (uta.fi)
  • Identify whether diabetes mellitus intervenes on ischemic preconditioning in symptomatic coronary artery disease patients. (biomedcentral.com)
  • Symptomatic multivessel coronary artery disease patients with preserved systolic ventricular function and a positive exercise test underwent two sequential exercise tests to demonstrate ischemic preconditioning. (biomedcentral.com)
  • Among diabetic patients, 62 (72 %) manifested an improvement in ischemic parameters consistent with ischemic preconditioning, whereas among nondiabetic patients, 60 (68 %) manifested ischemic preconditioning ( p = 0.62). (biomedcentral.com)
  • The analysis of patients who demonstrated ischemic preconditioning showed similar improvement in the time to 1.0 mm ST deviation between diabetic and nondiabetic groups (79.4 ± 47.6 vs 65.5 ± 36.4 s, respectively, p = 0.12). (biomedcentral.com)
  • In this study, diabetes mellitus was not associated with impairment in ischemic preconditioning in symptomatic coronary artery disease patients. (biomedcentral.com)
  • Furthermore, diabetic patients experienced an improvement in this significant mechanism of myocardial protection. (biomedcentral.com)
  • Among the cardiovascular diseases, ischemic heart disease is the most frequent [ 5 , 6 ] and is associated with the highest morbidity and mortality in patients with type 2 DM. (biomedcentral.com)
  • However, other studies seem to favor the use of insulin to restore the preconditioning effect in hyperglycemic patients or animals [ 16 , 17 ]. (hindawi.com)
  • Effect of remote ischemic preconditioning in the elderly patients with coronary artery disease with diabetes mellitus undergoing elective drug-eluting stent implantation. (qxmd.com)
  • Remote ischemic preconditioning and endothelial function in patients with acute myocardial infarction and primary PCI. (qxmd.com)
  • Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial. (qxmd.com)
  • A total of 184 patients with unstable angina undergoing elective PCI were randomly assigned to remote ischemic preconditioning group (induced by four times of 5-min inflations of a blood pressure cuff to 200 mmHg around the upper arm, followed by 5-min intervals of reperfusion at 1 h before PCI therapy) or control group (an uninflated cuff around the arm). (qxmd.com)
  • Successful completion of the PCI eventually included 130 cases of patients, including 72 cases in the remote ischemic preconditioning group and 58 cases in the control group. (qxmd.com)
  • Although this elevated mortality rate has been largely attributed to an accelerated rate of atherosclerosis, diabetic patients have a 2-fold higher risk of dying of a myocardial infarction than their nondiabetic counterparts. (ahajournals.org)
  • In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects. (springermedizin.de)
  • Therefore, we aimed to study the protective effect of ischemic preconditioning in patients with T1DM, and to explore the role of plasma insulin and glucose on this effect. (springermedizin.de)
  • Levosimendan is a calcium sensitizer that has been shown to prevent myocardial contractile depression in patients post cardiac surgery. (frontiersin.org)
  • Family physicians need to know the many criteria that identify patients at high and low risk of myocardial infarction and death so that high-risk patients can be appropriately referred for early surgical treatment and low-risk patients can be safely and appropriately treated medically. (aafp.org)
  • Association of renal insufficiency with treatment and outcomes after myocardial infarction in elderly patients. (semanticscholar.org)
  • BACKGROUND Patients with end-stage renal disease are known to have decreased survival after myocardial infarction, but the association of less severe renal dysfunction with survival after myocardial infarction is unknown. (semanticscholar.org)
  • OBJECTIVES To determine how patients with renal insufficiency are treated during hospitalization for myocardial infarction and to determine the association of renal insufficiency with survival after myocardial infarction. (semanticscholar.org)
  • Are cardioprotective drugs underused after a myocardial infarction in patients who suffer from chronic kidney disease? (semanticscholar.org)
  • Less use of standard guideline-based treatment of myocardial infarction in patients with chronic kidney disease: a Danish nation-wide cohort study. (semanticscholar.org)
  • Comparison of the effects of angiotensin converting-enzyme inhibitors and beta blockers on survival in elderly patients with reduced left ventricular function after myocardial infarction. (semanticscholar.org)
  • Renal insufficiency should not preclude the use of ACE inhibitors for patients with myocardial infarction and depressed left ventricular function. (semanticscholar.org)
  • Acute myocardial infarction in patients with end-stage renal disease. (semanticscholar.org)
  • Acute myocardial infarction contributes significantly to mortality in patients with coronary artery disease. (omicsonline.org)
  • A number of patients undergo coronary artery bypass graft (CABG) surgery as treatment for ischaemic heart disease. (clinicaltrials.gov)
  • Patients administered a Remote Ischaemic preconditioning protocol (three-5 min cycles of simultaneous inflation to cuffs placed on upper arm and thigh) prior to surgery and IV normal saline 2-5 mL/h during surgery. (clinicaltrials.gov)
  • Patients administered sham simulated Remote Ischaemic Preconditioning protocol prior to surgery and IV Glyceryl Trinitrate 2-5ml/h during surgery. (clinicaltrials.gov)
  • Its clinical significance has been suggested from retrospective analyses of data from patients suffering a myocardial infarction as well as from controlled PTCA studies. (foyles.co.uk)
  • Yet, in a sizable proportion of patients PPCI achieves epicardial coronary artery reperfusion but not myocardial reperfusion, a condition known as no-reflow ( 2 ). (onlinejacc.org)
  • At that time, they estimated that only "25% or less" of patients treated by thrombolysis had an optimal reperfusion, defined as a rapid, complete, and sustained coronary recanalization with adequate myocardial tissue perfusion. (onlinejacc.org)
  • The sulfonylthiourea HMR 1883 was designed as a cardioselective blocker of myocardial K ATP channels for the prevention of arrhythmic sudden death in patients with ischemic heart disease. (aspetjournals.org)
  • HMR 1883 differs from the prototype glibenclamide by several properties, which could make it appropriate for the prevention of severe ischemic arrhythmias in patients. (aspetjournals.org)
  • This is particularly important in IHD patients undergoing coronary artery bypass graft (CABG) surgery and in IHD patients presenting with an acute myocardial infarction (AMI) in which mortality and morbidity remain significant. (duke-nus.edu.sg)
  • An insight into the mechanisms underlying the cardioprotective properties of ischemic preconditioning has, on the one hand, directed research aimed at identification of novel therapeutic agents for the treatment of ischemic heart disease, and on the other, questioned the use of potentially deleterious agents that may abolish the cardioprotective actions of ischemic preconditioning in patients with angina. (ucl.ac.uk)
  • Current studies are under way to evaluate the potential protection afforded by these "preconditioning" agents in patients with acute coronary syndromes, and some early reports provide some basis for optimism that a beneficial and clinically detectable improvement in myocardial protection may be possible. (ucl.ac.uk)
  • These findings might have implications for current clinical practice in hemodynamically unstable patients suffering from myocardial ischemia. (eurekaselect.com)
  • Randomized control of sympathetic drive with continuous intravenous esmolol in patients with acute st-segment elevation myocardial infarction: The beta-blocker therapy in acute myocardial infarction (BEAT-AMI) Trial. (eurekaselect.com)
  • However, antagonism of A 1 ARs is potentially a concern when using these agents in patients with ischemic heart disease. (aspetjournals.org)
  • Increased Symmetric Dimethylarginine Level Is Associated with Worse Hospital Outcomes through Altered Left Ventricular Ejection Fraction in Patients with Acute Myocardial Infarction. (amedeo.com)
  • Kidney function and specific mortality in 60-80 years old post-myocardial infarction patients: A 10-year follow-up study. (amedeo.com)
  • Prognostic power of global 2D strain according to left ventricular ejection fraction in patients with ST elevation myocardial infarction. (amedeo.com)
  • Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study. (amedeo.com)
  • Factors attributed to the higher in-hospital mortality of ST elevation myocardial infarction patients admitted during off-hour in comparison with those during regular hour. (amedeo.com)
  • However, there has been a gradual shift in the populations being treated by PCI: primary angioplasty is now the recommended emergency treatment for ST-elevation myocardial infarction (STEMI), and early angiography and revascularisation are recommended in patients with other acute coronary syndromes (ACS). (hospitalhealthcare.com)
  • Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance. (docphin.com)
  • New progresses in myocardial protection in the settings of acute myocardial infarction treatment put forward the its clinical use to a broader field. (clinicaltrials.gov)
  • A clinical correlate to preconditioning? (springer.com)
  • Myocardial salvage in acute myocardial infarction-challenges in clinical translation. (springer.com)
  • Clinical practice has confirmed the safety and efficacy of these two methods of myocardial protection . (bvsalud.org)
  • While recurring myocardial infarction and enhanced susceptibility to arrhythmias are potential candidates for the observed clinical results, epidemiologists have concluded that the dominant cause for the elevated mortality rate is the development of congestive heart failure. (ahajournals.org)
  • Treatment considerations for myocardial stunning should be determined based on the clinical judgment of the cardiologist or physician, the degree of LV impairment and symptoms, and the wishes of the person. (wikipedia.org)
  • A successful myocardial protection during open heart surgery has an important clinical significance for overall short- and long-term outcome. (frontiersin.org)
  • PREDICT: A simple risk score for clinical severity and long-term prognosis after hospitalization for acute myocardial infarction or unstable angina: the Minnesota heart survey. (semanticscholar.org)
  • Whether or not preconditioning can be achieved pharmacologically in the clinical setting remains to be established. (foyles.co.uk)
  • In particular, thrombus aspiration before stent implantation prevents distal embolization and has been recently shown to improve myocardial perfusion and clinical outcome as compared with the standard procedure. (onlinejacc.org)
  • BACKGROUND: Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. (uzh.ch)
  • Clinical implications of ischemic pre- and post-conditioning. (duke-nus.edu.sg)
  • This is due in part to underperfusion of the subendocardial layers of the left ventricle when the coronary circulation is restored after an ischemic episode. (ahajournals.org)
  • obJeCtives: To examine whether changes in nitric oxide (NO) bioavailability occurring during a 25 min occlusion of the left anterior descending coronary artery and following ischemic preconditioning (PC) in anesthetized dogs (chloralose and urethane, intravenous) are associated with changes in the activation of NO synthase (NOS) enzymes. (pulsus.com)
  • Myocardial stunning was first described in laboratory canine experiments in the 1970s where LV wall abnormalities were observed following coronary artery occlusion and subsequent reperfusion. (wikipedia.org)
  • Ischemic preconditioning (IPC) through purposeful circulatory occlusion may enhance exercise performance. (humankinetics.com)
  • METHODS AND RESULTS: Acute myocardial infarction was induced by a 90-min balloon occlusion of the left anterior descending coronary artery (LAD) in domestic juvenile female pigs. (uzh.ch)
  • In conclusion, the K ATP channel blocker HMR 1883, which had no effect on hemodynamics and ECG under baseline conditions, reduced the extent of ischemic ECG changes and sudden death due to ventricular fibrillation during coronary occlusion. (aspetjournals.org)
  • However, diabetes mellitus and acute hyperglycemia have been shown to counteract the cardioprotective effects of both ischemic and pharmacological preconditioning in animals and humans [ 7 , 10 - 12 ]. (hindawi.com)
  • Parratt JR (1995) Possibilities for the pharmacological exploitation of ischemic preconditioning. (springer.com)
  • 0.05) suggesting that the mutant female mice were more susceptible to ischemic stress. (ahajournals.org)
  • Conclusions: Lack of ischemic preconditioning, enhanced inflammatory response, and subsequent LV dysfunction are related to the development of VT/VF after STEMI. (elsevier.com)
  • The area of dysfunction should also maintain normal perfusion, detected via Positron Emission Tomography, echocardiography with contrast, and/or thallium scintigraphy in order for a diagnosis of myocardial stunning to be considered. (wikipedia.org)
  • Some evidence supports the use of inotropic drugs in the case of severe myocardial dysfunction. (wikipedia.org)
  • MYOCARDIAL PROTECTION' Refers to strategies and methodologies used either to attenuate or to prevent postischemic myocardial dysfunction that occurs during and after heart surgery. (slideserve.com)
  • Background: Animal studies on cardiac arrest found that a combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction. (eurekaselect.com)
  • Epinephrine increases the severity of postresuscitation myocardial dysfunction. (eurekaselect.com)
  • Preventive strategies to avoid primary graft dysfunction (PGD) have been focused on better donor choice and maintenance, heart preservation methods in long-distance retrievals with prolonged ischemia time, and better myocardial protection during implantation, among others. (intechopen.com)
  • Background: Sustained ventricular tachycardia and ventricular fibrillation (VT/VF) are major complications of ST-elevation myocardial infarction (STEMI), even in the era of reperfusion therapy. (elsevier.com)
  • Myocardial samples for inducible and endothelial nitric oxide synthases (iNOS, eNOS) estimation were drawn twice: before and after cannulation for cardiopulmonary bypass from the auricle of the right atrium. (biomedsearch.com)
  • There is however little data concerning the effects of elevated cardiac endothelial nitric oxide synthase (eNOS) expression on myocardial tolerance to ischaemia. (ovid.com)
  • Cardiac output, coronary flow, peak aortic systolic pressure and total work were determined before hearts were preconditioned by 4 × 5 min cycles of ischaemia/reperfusion, and then subjected to 20 min total global ischaemia, followed by reperfusion. (ovid.com)
  • The effects of preconditioning on development of reperfusion-induced ventricular fibrillation (VF), ventricular tachycardia (VT), free radical formation, and ion shifts, particularly those of Na, K, Ca, and Mg, were studied in isolated rat heart. (elsevier.com)
  • Some evidence suggests that brief, repetitive episodes of myocardial ischemia may result in chronic myocardial stunning and ventricular contractile impairment. (wikipedia.org)
  • A Common Variant in SCN5A and the Risk of Ventricular Fibrillation Caused by First ST-Segment Elevation Myocardial Infarction. (amedeo.com)
  • Correction: Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism. (amedeo.com)
  • Importantly, prolonged myocardial ischemia was associated with increased mortality in eNOS(-/-) mice, and the survival rate was higher in female eNOS(-/-) mice compared with male eNOS(-/-) mice. (biomedsearch.com)
  • Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. (semanticscholar.org)
  • Li Y, Kloner A (1994) Cardioprotective effects of ischemic preconditioning can be recaptured after they are lost. (springer.com)
  • Previous studies suggest that the diabetic heart is more resistant to the cardioprotective effects of myocardial ischaemic preconditioning. (bmj.com)
  • Sevoflurane, Propofol and Carvedilol Block Myocardial Protection by Limb Remote Ischemic Preconditioning. (nih.gov)
  • Ischemic heart disease is the leading cause of death for both men and women worldwide, accruing 7.4 million deaths in 2012. (docphin.com)
  • Diabetes mellitus is a one of the major risk factor for ischemic heart disease. (biomedcentral.com)
  • Ischemic heart disease is one of the most common disorders managed by family physicians. (aafp.org)
  • Moreover, the morbidity and socioeconomic consequences of coronary heart disease will be accentuated in future years by the growing numbers of elderly persons in the U.S. population and the increased frequency of ischemic heart disease in the elderly. (aafp.org)
  • A considerable body of epidemiology associates moderate alcohol consumption with significantly reduced risks of coronary heart disease and, albeit currently a less robust relationship, cerebrovascular (ischemic) stroke. (pubmedcentralcanada.ca)
  • Ischaemic heart disease is a leading cause of mortality in the western world. (clinicaltrials.gov)
  • Ischemic heart disease is also prevailing in the aged people. (springer.com)
  • Ischaemic heart disease (IHD) is the leading cause of death and disability in Singapore and worldwide. (duke-nus.edu.sg)
  • Ischemic heart disease, as the underlying cause of most cases of acute myocardial infarction (AMI), congestive heart failure, arrhythmias, and sudden cardiac death, is the leading cause of morbidity and mortality in all industrialized nations. (ahajournals.org)
  • In the United States, ischemic heart disease causes nearly 20% of all deaths (≈600 000 deaths each year), with many of these deaths occurring before the patient arrives at the hospital. (ahajournals.org)
  • As the population grows older and comorbidities such as obesity and diabetes become more prevalent, the enormous public health burden caused by ischemic heart disease is likely to increase even further. (ahajournals.org)
  • Thus, recent studies [ 13 ] have focused on the understanding of such myocardial responses, aiming at discovering the mechanisms of myocardial protection to achieve less aggression and a better prognosis. (biomedcentral.com)
  • Our results show that preconditioning can modify the ischemia/reperfusion-induced deleterious ion shifts and free radical formation and consequently protect the heart against life-threatening arrhythmias. (elsevier.com)
  • Catecholamine release and arrhythmias in acute myocardial ischemia. (springer.com)
  • Remodeling of cardiac tissue architecture is the common denominator of a variety of cardiovascular pathologies including myocardial infarction, coronary artery disease, hypertension, cardiomyopathy, and arrhythmias ( 1 ). (frontiersin.org)
  • The arrhythmogenic potential is strongly enhanced by the local nature of myocardial ischemia, which translates into spatial heterogeneities in excitability, conduction, and refractoriness favoring reentrant arrhythmias. (aspetjournals.org)
  • 25- Altuğ S, Demiryürek AT, Ak D, Tunçel M, Kanzık İ. (2001) Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts. (gantep.edu.tr)
  • Mechanisms of myocardial ischemic preconditioning are age related: PKC" by Karin Przyklenk, Guohu Li et al. (umassmed.edu)
  • The underlying mechanisms of myocardial stunning have remained the subject of debate for several decades. (wikipedia.org)
  • This study examined the hypothesis that acute hyperglycemia (HG) blocks ischemic preconditioning (IPC) by inhibiting Akt phosphorylation. (hindawi.com)
  • Results from canine experimental trials investigating the oxygen free-radical hypothesis for myocardial stunning have shown a reduction in free radical generation and improvement in myocardial function following anti-oxidant infusion. (wikipedia.org)
  • The success of this procedure, termed 'delayed RIPost', was unexpected, in view of the prevailing hypothesis that * Derek M. Yellon the majority of myocardial reperfusion cell death is due to [email protected] the opening of mitochondrial permeability transition pores The Hatter Cardiovascular Institute, University College (mPTP), thought to occur during the first few minutes of London, 67 Chenies Mews, London WC1E 6HX, UK reperfusion [29, 46]. (deepdyve.com)
  • HG abolishes the cardioprotective effect of preconditioning by inhibiting Akt phosphorylation. (hindawi.com)
  • Normalization of blood glucose with insulin suffices to recover the cardioprotective effect of preconditioning. (hindawi.com)
  • In the setting of hyperglycemia, only a few conflicting results have been reported on the effect of preconditioning-mimetic insulin. (hindawi.com)
  • However, remote ischaemic postconditioning does not appear to require activation of this component of the RISK pathway to confer its cardioprotective effect. (bmj.com)
  • However, whether celastrol can exert protective effect on myocardial ischem. (bioportfolio.com)
  • The effect of remote ischemic preconditioning during coronary artery bypass graft surgery: a randomised controlled trial. (duke-nus.edu.sg)
  • The purpose of this study was to evaluate the neuroprotective effect of agmatine in a transient ischemic cat model by using MR perfusion imaging and histopathologic analyses. (ajnr.org)
  • Animal studies suggest remote ischemic preconditioning increases levels of interleukin 10. (clinicaltrials.gov)
  • Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study: a prospective, randomized control trial. (qxmd.com)
  • Is there protection by remote ischaemic preconditioning? (qxmd.com)
  • Strain data in the at-risk segments were compared with values derived from remote non-ischemic segments in both groups. (ahajournals.org)
  • Delta opioid receptor Remote ischemic conditioning Citations Murry, C. E. (wikipedia.org)
  • Sham Remote ischaemic preconditioning with IV normal saline 2-5ml/hour. (clinicaltrials.gov)
  • Brandenburger T, Grievink H, Heinen N, Barthel F, Huhn R, Stachuletz F, Kohns M, Pannen B, Bauer I (2014) Effects of remote ischemic preconditioning and myocardial ischemia on microRNA-1 expression in the rat heart in vivo. (springer.com)
  • This phenomenon became dium, protected a remote myocardial territory of the same known as remote ischaemic preconditioning (RIPer). (deepdyve.com)
  • Exercise appears to restore preconditioning protection in aged rat hearts, possibly due to an increase in intracellular polyamines and an improvement in mitochondrial function in response to a preconditioning stimulus. (hindawi.com)
  • Therefore, the down-regulation of SUR2-150 served as the "stimulus" in preconditioning signaling for WT male mice. (ahajournals.org)
  • We recently demonstrated that exogenous nitric oxide (NO) acts as a trigger for preconditioning in the isolated rat heart model. (ovid.com)
  • Here myocardial bioenergetic dynamics were assessed by 18 O-assisted 31 P-NMR spectroscopy in control or preconditioned hearts from wild-type (WT) or Kir6.2-knockout (Kir6.2-KO) mice that lack metabolism-sensing sarcolemmal ATP-sensitive K + (K ATP ) channels. (elsevier.com)
  • The major findings were that regardless of sex, WT mice exhibited robust IPC with significantly smaller myocardial infarction, whereas eNOS(-/-) mice did not. (biomedsearch.com)
  • Myocardial NAD + levels were maintained in the PARS-deficient mice during reperfusion, while depleted in the wild-type mice. (utmb.edu)
  • Pre-ischaemic mechanical function (rate pressure product and cardiac output) was similar for wild-type and transgenic mice of both sexes. (ovid.com)
  • In vivo, AMPK activation prevents myocardial hypertrophy and the concomitant rise of O-GlcNAcylation in wild-type but not in AMPKα2-deficient mice. (bireme.br)
  • In this study, we evaluated the ischemic responses in different genders of SUR2 knockout mutant mice, in which a 150-kDa SUR2 long variant (SUR2-150) was disrupted. (ahajournals.org)
  • An experimental ischemia model using intact mice was applied to compare the ischemic "phenotypes" in two genders. (ahajournals.org)
  • Expression of SUR2-150 in WT male mice showed that its level decreased dramatically after IPC compared to non-preconditioned controls while the level of SUR2-150 increased in WT female mice after IPC compared to their controls. (ahajournals.org)
  • The male mutant mice that had no SUR2-150 did not require the preconditioning procedure to reach a protective state. (ahajournals.org)
  • Methods: C57BL/6J mice were subjected to 60 min of myocardial ischemia and 120 min of reperfusion. (eurekaselect.com)
  • In WT vs. Kir6.2-KO hearts, preconditioning induced a significantly higher total ATP turnover (232 ± 20 vs. 155 ± 15 nmol·mg protein -1 ·min -1 ), ATP synthesis rate (58 ± 3 vs. 46 ± 3% 18 O labeling of γ-ATP), and ATP consumption rate (51 ± 4 vs. 31 ± 4% 18 O labeling of P i ) after ischemia-reperfusion. (elsevier.com)
  • In nonpreconditioned ischemic hearts, 30-min ischemia followed by 30-min reperfusion resulted in three and four-fold accumulation of myocardial Na and Ca, respectively, and a decrease of ~50% in both K and Mg. Four cycles of preconditioning significantly protected hearts against ischemia, reperfusion- induced myocardial Na and Ca accumulation, and K and Mg loss. (elsevier.com)
  • In vitro studies demonstrated that CLK cells grown under normoxic conditions did not migrate significantly in response to SDF-1, nor was there significant engraftment of functional effects of these cells following the intravenous administration 1 hour after acute myocardial infarction. (ahajournals.org)
  • Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. (duke-nus.edu.sg)
  • Morphine Does Not Affect Myocardial Salvage in ST-Segment Elevation Myocardial Infarction. (amedeo.com)
  • Higher incidence of hypotension episodes in women during the sub-acute phase of ST elevation myocardial infarction and relationship to covariates. (amedeo.com)
  • Accurate detection of regional myocardial blood flow and contraction function abnormalities must be detected at levels of high sensitivity. (wikipedia.org)
  • 7 They further investigate how cardiac stem cell exposure to hypoxia before their intravenous administration alters cardiac stem cell engraftment and subsequent effects on myocardial repair. (ahajournals.org)
  • A theoretical difference in risk exists because the drugs vary with respect to hypoglycemic risk, sulfonylurea receptor selectivity, and effects on myocardial ischemic preconditioning. (medpagetoday.com)