Ischemia
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Brain Ischemia
Reperfusion Injury
Myocardial Reperfusion Injury
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Reperfusion
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
Warm Ischemia
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
Cold Ischemia
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Ischemic Preconditioning
Gerbillinae
Spinal Cord Ischemia
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
Disease Models, Animal
Myocardium
Rats, Sprague-Dawley
Ischemic Preconditioning, Myocardial
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Rats, Wistar
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Infarction, Middle Cerebral Artery
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Myocardial Reperfusion
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Hindlimb
Myocardial Infarction
Coronary Disease
Hemodynamics
Cardiotonic Agents
Dogs
Mesenteric Vascular Occlusion
Obstruction of the flow in the SPLANCHNIC CIRCULATION by ATHEROSCLEROSIS; EMBOLISM; THROMBOSIS; STENOSIS; TRAUMA; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as PERIARTERITIS NODOSA and THROMBOANGIITIS OBLITERANS. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)
Arterial Occlusive Diseases
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Electrocardiography
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Lower Extremity
Neurons
Exercise Test
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Myocardial Stunning
Hippocampus
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Hypothermia, Induced
Ischemic Postconditioning
Cell Death
Rabbits
Laser-Doppler Flowmetry
Cerebral Cortex
Phosphocreatine
Adenosine
Angina Pectoris
Prosencephalon
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Neovascularization, Physiologic
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Oxygen
Adenosine Triphosphate
Random Allocation
Collateral Circulation
Lactic Acid
Arrhythmias, Cardiac
Brain Infarction
Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
Hypoxia-Ischemia, Brain
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Peroxidase
Ventricular Function, Left
Limb Salvage
Electrocardiography, Ambulatory
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
Rats, Inbred Strains
Mesenteric Artery, Superior
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
L-Lactate Dehydrogenase
Kidney
Myocytes, Cardiac
In Situ Nick-End Labeling
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Immunohistochemistry
Oxidative Stress
Tourniquets
Cytoprotection
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Recovery of Function
Enzyme Inhibitors
Tomography, Emission-Computed, Single-Photon
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Hypoxia, Brain
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Analysis of Variance
Models, Animal
Colitis, Ischemic
Acidosis
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Organ Preservation
Blotting, Western
Oxygen Consumption
Blood Flow Velocity
Protective Agents
Heart Ventricles
Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Cardioplegic Solutions
Coronary Angiography
Glucose
Cells, Cultured
Prospective Studies
Middle Cerebral Artery
Dose-Response Relationship, Drug
Heart Arrest, Induced
Energy Metabolism
Cats
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Ventricular Pressure
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
Blood-Brain Barrier
Superoxide Dismutase
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Antioxidants
Caspase 3
Ventricular Fibrillation
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Free Radical Scavengers
Myocardial Perfusion Imaging
Popliteal Artery
Hydrogen-Ion Concentration
Acute Kidney Injury
Peripheral Vascular Diseases
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Muscle, Skeletal
Intestines
Endothelium, Vascular
Embolectomy
Nitric Oxide Synthase
Cell Survival
Follow-Up Studies
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Evoked Potentials, Somatosensory
Dizocilpine Maleate
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
Risk Factors
Liver
Echocardiography, Stress
Guanidines
Acetanilides
Magnetic Resonance Imaging
Organ Preservation Solutions
Free Radicals
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Angioplasty, Balloon
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Purinergic P1 Receptor Antagonists
Iliac Artery
Isoflurane
Intraoperative Complications
Cerebrovascular Disorders
Cardiovascular Agents
Allopurinol
Severity of Illness Index
Intermittent Claudication
Postoperative Complications
Extracellular Space
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Microdialysis
Glutamic Acid
Thallium Radioisotopes
Infarction
Capillary Permeability
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Splanchnic Circulation
Neutrophil Infiltration
Tomography, X-Ray Computed
Electroencephalography
Potassium Channels
Swine, Miniature
Dipyridamole
Antipyrine
Expression of thrombospondin-1 in ischemia-induced retinal neovascularization. (1/5696)
Thrombospondin-1 is an extracellular matrix protein that inhibits endothelial cell proliferation, migration, and angiogenesis. This study was performed to investigate the role of thrombospondin-1 in ischemic retinal neovascularization. In a murine model of retinal neovascularization, thrombospondin-1 mRNA was increased from postnatal day 13 (P13), with a threefold peak response observed on P15, corresponding to the time of development of retinal neovascularization. Prominent expression of thrombospondin-1 was observed in neovascular cells, specifically, cells adjacent to the area of nonperfusion. It has been suggested that vascular endothelial growth factor (VEGF) plays a major role in ischemia-induced retinal neovascularization of this model, so we studied the effects of VEGF on thrombospondin-1 expression. In bovine retinal microcapillary endothelial cells, VEGF induced a biphasic response of thrombospondin-1 expression; VEGF decreased thrombospondin-1 mRNA 0.41-fold after 4 hours, whereas it increased, with a threefold peak response, after 24 hours. VEGF-induced endothelial cell proliferation was completely inhibited by exogenous thrombospondin-1 and increased by 37.5% with anti-thrombospondin-1 antibody. The present findings suggest that, in the ischemic retina, retinal neovascular cells increase thrombospondin-1 expression, and VEGF may stimulate endogenous thrombospondin-1 induction, which inhibits endothelial cell growth. VEGF-mediated thrombospondin-1 induction in ischemia-induced angiogenesis may be a negative feedback mechanism. (+info)Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. (2/5696)
Diabetes is a major risk factor for coronary and peripheral artery diseases. Although diabetic patients often present with advanced forms of these diseases, it is not known whether the compensatory mechanisms to vascular ischemia are affected in this condition. Accordingly, we sought to determine whether diabetes could: 1) impair the development of new collateral vessel formation in response to tissue ischemia and 2) inhibit cytokine-induced therapeutic neovascularization. Hindlimb ischemia was created by femoral artery ligation in nonobese diabetic mice (NOD mice, n = 20) and in control C57 mice (n = 20). Hindlimb perfusion was evaluated by serial laser Doppler studies after the surgery. In NOD mice, measurement of the Doppler flow ratio between the ischemic and the normal limb indicated that restoration of perfusion in the ischemic hindlimb was significantly impaired. At day 14 after surgery, Doppler flow ratio in the NOD mice was 0.49+/-0.04 versus 0.73+/-0.06 for the C57 mice (P< or =0.005). This impairment in blood flow recovery persisted throughout the duration of the study with Doppler flow ratio values at day 35 of 0.50+/-0.05 versus 0.90+/-0.07 in the NOD and C57 mice, respectively (P< or =0.001). CD31 immunostaining confirmed the laser Doppler data by showing a significant reduction in capillary density in the NOD mice at 35 days after surgery (302+/-4 capillaries/mm2 versus 782+/-78 in C57 mice (P< or =0.005). The reduction in neovascularization in the NOD mice was the result of a lower level of vascular endothelial growth factor (VEGF) in the ischemic tissues, as assessed by Northern blot, Western blot and immunohistochemistry. The central role of VEGF was confirmed by showing that normal levels of neovascularization (compared with C57) could be achieved in NOD mice that had been supplemented for this growth factor via intramuscular injection of an adenoviral vector encoding for VEGF. We conclude that 1) diabetes impairs endogenous neovascularization of ischemic tissues; 2) the impairment in new blood vessel formation results from reduced expression of VEGF; and 3) cytokine supplementation achieved by intramuscular adeno-VEGF gene transfer restores neovascularization in a mouse model of diabetes. (+info)Modulation of the thermoregulatory sweating response to mild hyperthermia during activation of the muscle metaboreflex in humans. (3/5696)
1. To investigate the effect of the muscle metaboreflex on the thermoregulatory sweating response in humans, eight healthy male subjects performed sustained isometric handgrip exercise in an environmental chamber (35 C and 50 % relative humidity) at 30 or 45 % maximal voluntary contraction (MVC), at the end of which the blood circulation to the forearm was occluded for 120 s. The environmental conditions were such as to produce sweating by increase in skin temperature without a marked change in oesophageal temperature. 2. During circulatory occlusion after handgrip exercise at 30 % MVC for 120 s or at 45 % MVC for 60 s, the sweating rate (SR) on the chest and forearm (hairy regions), and the mean arterial blood pressure were significantly above baseline values (P < 0.05). There were no changes from baseline values in the oesophageal temperature, mean skin temperature, or SR on the palm (hairless regions). 3. During the occlusion after handgrip exercise at 30 % MVC for 60 s and during the occlusion alone, none of the measured parameters differed from baseline values. 4. It is concluded that, under mildly hyperthermic conditions, the thermoregulatory sweating response on the hairy regions is modulated by afferent signals from muscle metaboreceptors. (+info)Hypothermic neuroprotection of peripheral nerve of rats from ischaemia-reperfusion injury. (4/5696)
Although there is much information on experimental ischaemic neuropathy, there are only scant data on neuroprotection. We evaluated the effectiveness of hypothermia in protecting peripheral nerve from ischaemia-reperfusion injury using the model of experimental nerve ischaemia. Forty-eight male Sprague-Dawley rats were divided into six groups. We used a ligation-reperfusion model of nerve ischaemia where each of the supplying arteries to the sciatic-tibial nerves of the right hind limb was ligated and the ligatures were released after a predetermined period of ischaemia. The right hind limbs of one group (24 rats) were made ischaemic for 5 h and those of the other group (24 rats) for 3 h. Each group was further divided into three and the limbs were maintained at 37 degrees C (36 degrees C for 5 h of ischaemia) in one, 32 degrees C in the second and 28 degrees C in the third of these groups for the final 2 h of the ischaemic period and an additional 2 h of the reperfusion period. A behavioural score was recorded and nerve electrophysiology of motor and sensory nerves was undertaken 1 week after surgical procedures. At that time, entire sciatic-tibial nerves were harvested and fixed in situ. Four portions of each nerve were examined: proximal sciatic nerve, distal sciatic nerve, mid-tibial nerve and distal tibial nerve. To determine the degree of fibre degeneration, each section was studied by light microscopy, and we estimated an oedema index and a fibre degeneration index. The groups treated at 36-37 degrees C underwent marked fibre degeneration, associated with a reduction in action potential and impairment in behavioural score. The groups treated at 28 degrees C (for both 3 and 5 h) showed significantly less (P < 0.01; ANOVA, Bonferoni post hoc test) reperfusion injury for all indices (behavioural score, electrophysiology and neuropathology), and the groups treated at 32 degrees C had scores intermediate between the groups treated at 36-37 degrees C and 28 degrees C. Our results showed that cooling the limbs dramatically protects the peripheral nerve from ischaemia-reperfusion injury. (+info)Age-related outcome for peripheral thrombolysis. (5/5696)
OBJECTIVES: To investigate the age-related outcome of peripheral thrombolysis and determine for which patient group this treatment is worthwhile. DESIGN AND METHODS: A combined retrospective and prospective analysis of consecutive patients undergoing thrombolysis for acute lower-limb ischaemia was made with respect to age-related outcome and other risk factors. RESULTS: One hundred and two patients underwent thrombolysis for acute limb ischaemia. In the under 60 age group there was a 40% amputation rate. Seventy-three per cent of this group smoked. In the over 80 age group, the amputation rate was 15% and only 8% were smokers. CONCLUSION: Advancing age is not an adverse risk factor for thrombolysis which appears to be safe and effective in this patient group. There is a high incidence of smoking in the younger age group (< 60 years), in whom failed thrombolysis frequently leads to amputation. (+info)Accumulation of N-acyl-ethanolamine phospholipids in rat brains during post-decapitative ischemia: a 31p NMR study. (6/5696)
Phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy has been used to study accumulation of N-acyl-ethanolamine phospholipids in rat brains during post-decapitative ischemia. Lipids were extracted from rat brain homogenates and the extracts were thoroughly washed with aq. potassium ethylenediaminetetraacetic acid (EDTA). The lower organic phases were isolated and evaporated to dryness under a stream of nitrogen and the lipids were redissolved in CDCl3-CH3OH-H2O 100.0:29.9:5.2 (v/v/v) for NMR analysis. Increasing the period of post-decapitative ischemia resulted in an accumulation of two signals in the NMR spectra at 0.18 and 0.22 ppm (relative to the chemical shift of 1,2-diacyl-sn-glycero-3-phosphocholine (PCDIACYL) at -0.84 ppm). These signals were identified as originating from 1,2-diacyl-sn-glycero-3-phospho-(N-acyl)-ethanolamine (NAPEDIACYL) and 1-(1'-alkenyl)-2-acyl-sn -glycero-3-phospho-(N-acyl)-ethanolamine (NAPEPLAS), respectively, by spiking with authentic materials. Additionally, the identification was verified by thin-layer chromatography, which also showed the accumulation of N-acyl-ethanolamine phospholipids. The use of K-EDTA instead of the commonly used Cs-EDTA in the preparation of the NMR samples allowed the separation of the chemical shifts of N-acyl-ethanolamine phospholipids from those of the ethanolamine phospholipids. Moreover, the chemical shift of cardiolipin was moved from 0.15 ppm observed with Cs-EDTA to about 0.31 ppm with K-EDTA. The present study demonstrates that it is possible to detect and quantify post-decapitative accumulation of NAPE subclasses (NAPEDIACYL and NAPEPLAS) in rat brains by the use of 31P NMR spectroscopy. (+info)Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans. (7/5696)
Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of approximately 1 l/min, heart rate increased from 66 +/- 4 to 86 +/- 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 +/- 3 to 110 +/- 8 beats/min. In contrast, blood pressure increased only in C (from 88 +/- 3 to 99 +/- 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI. (+info)CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia. (8/5696)
BACKGROUND AND PURPOSE: Both Doppler sonography (DS) and spiral CT angiography (CTA) are noninvasive vascular assessment tools with a high potential for application in acute cerebral ischemia. The usefulness of CTA for vascular diagnosis in acute basilar artery (BA) ischemia has not yet been studied. METHODS: We prospectively studied 19 patients (mean+/-SD age, 58+/-11 years) with clinically suspected acute BA occlusion by DS and CTA. Prior extracranial and transcranial DS was performed in all but 1 patient, with DS 4 hours after CTA. In 6 of 19 patients, we performed digital subtraction angiography. RESULTS: CTA was diagnostic in all but 1 patient. CTA revealed complete BA occlusion in 9 patients and incomplete BA occlusion with some residual flow in 2 patients. A patent BA was shown in 7 patients. Because of severe BA calcification, CTA results were inconclusive in 1 patient. DS was diagnostic in only 7 of 19 patients, indicating certain BA occlusion in 3 patients and BA patency in 4 patients. In an additional 9 patients, the results of DS were inconclusive. DS was false-negative in 2 patients with distal BA occlusion shown by CTA and digital subtraction angiography. In 1 patient with DS performed after CTA, recanalization was demonstrated. In addition to the diagnosis or exclusion of BA occlusion, CTA provided information on the exact site and length of BA occlusion and collateral pathways. In our series, CTA results prompted indication for intra-arterial thrombolysis in 5 patients. CONCLUSIONS: CTA was superior to DS in the assessment of BA patency in patients with the syndrome of acute BA ischemia in terms of feasibility and conclusiveness, particularly in cases with distal BA occlusion. Our study confirmed the usefulness of combined extracranial and transcranial DS in the diagnosis and exclusion of proximal BA occlusion. (+info)
Critical Limb Ischemia Market Analysis, Leading Companies, Emerging Drugs and Epidemiology Forecast - Sikkim Journal
Critical Limb Ischemia Market Analysis, Leading Companies, Emerging Drugs and Epidemiology Forecast - Maharashtra Herald
Surgery 101: 292. Acute Limb Ischemia
Endovascular-First Treatment Is Associated With Improved Amputation-Free Survival in Patients With Critical Limb Ischemia<...
Combination Adult Stem Cell Therapy Improves Severe Limb Ischemia | DAIC
Symposium to Explore the Impact of Vascular Dissections on Critical Limb Ischemia Patients at AMP 2018A Case-Based Look at...
Chronic Limb Ischaemia - Clinical Features - Management - TeachMeSurgeryTeachMeSurgery
Acute limb ischaemia - Wikipedia
Chronic lower limb ischemia and advanced renal failure. Do we possess sufficient therapeutic knowledge? - International...
Veterans study suggests surgery is still dominant revascularisation approach for critical limb ischaemia - BIBA Medtech Insights
Abstract 15690: Longitudinal in vivo Assessment of Bone Marrow Mononuclear Cell Therapy for Ischemia-Mediated...
Blood perfusion disorders of the upper extremities (upper extremity ischemia)
Critical Limb Ischemia Sample Report covering Drugs, Companies, Market & Epidemiology analysis for Critical Limb Ischemia in...
Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a...
Comparison of venous and HePTFE tibial and peroneal bypasses in critical limb ischemia patients unsuitable for endovascular...
Major amputation over utilised globally for critical limb ischaemia | Interventional News
Japan - Peripheral Artery Disease and Critical Limb Ischemia Prevalence and Incidence 2017 - The Sage Group
Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI) - Full Text View - ClinicalTrials.gov
Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb Ischemia - Full...
Impairment in Postischemic Neovascularization in Mice Lacking the CXC Chemokine Receptor 3 | Circulation Research
BAD transmission and SAD distribution: A new scenario for critical limb ischemia<...
About Critical Limb Ischemia Treatment | RAYUS Radiology
Contemporary Management of Critical Limb Ischemia the BEST Is Yet to Come<...
Critical Limb Ischemia - Genesis Health Services
Apical ischemia stress test - Answers on HealthTap
Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia |...
A basic study on molecular hydrogen (H 2 ) inhalation in acute cerebral ischemia patients for safety check with physiological...
Development of a microgel-based cell delivery platform for critical limb ischemia
Routine Angiography for Critical Limb Ischemia | Vascular Disease Management
Therapeutic vascular growth in myocardial and peripheral ischemia
Transcapillary forces and the development of oedema in the lower limb of patients with chronic critical limb ischaemia (CLI).
DSpace at KOASAS: PEGylated substance P augments therapeutic angiogenesis in diabetic critical limb ischemia
Clinical outcomes after isolated infrapopliteal revascularization in hemodialysis patients with critical limb ischemia:...
Outcomes of upper extremity interventions for chronic critical ischemia<...
Critical Limb Ischemia (CLI): UC Davis Vascular Center
Assessment of Blood-Borne Autologous Angiogenic Cell Precursors Therapy in Patients With Critical Limb Ischemia | VCH Research...
Abstract 25: Critical Limb Ischemia Progression is Associated with an Inflammatory Profile | Arteriosclerosis, Thrombosis, and...
Meaning of catabolic markers in acute limb ischemia | Kazimierczak | Chirurgia Polska (Polish Surgery)
Lecture Slides; Surgery; Chronic lower limb ischemia
Phase 2 study of JVS-100 for the treatment of critical limb ischemia (CLI) - MPR
Critical Limb Ischemia (CLI) | Minimally Invasive Vascular
Best Endovascular Versus Best Surgical Therapy in Patients With Critical Limb Ischemia | Columbia University Department of...
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI) | Yale Center for Clinical...
Critical Limb Ischemia 2.0: Evolving Strategies To Boost Patient Outcomes | AMP Central
Anatomical Evaluation of Great Saphenous Vein as Material for Conduit in Bypass Surgery for Critical Limb Ischemia
Critical Limb Ischemia Course 2018 - Vascular Society
Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive...
Ergotamine-induced upper extremity ischemia: A case report<...
Global Critical Limb Ischemia Treatment Market Worth USD 5,390 Million By 2025: Zion Market Research - ZMR News Magazine
FEMOROPOPLITEAL BYPASS FOR CHRONIC LOWER LIMB ISCHEMIA: REVIEW OF 48 CASES.
Mesenteric Ischemia | Principles of Critical Care, 4e | AccessSurgery | McGraw-Hill Medical
Moderate intake of red wine improves ischemia-induced neovascularization in diabetic mice-Roles of endothelial progenitor cells...
Mechanisms Underlying the Impairment of Ischemia-Induced Neovascularization in Matrix Metalloproteinase 2-Deficient Mice |...
A novel role for milrinone in neonatal acute limb ischaemia: successful conservative treatment of thrombotic arterial occlusion...
Asian Science Citation Index - Articles written by Y Kawashima
Procedural and clinical outcomes with catheter-based plaque excision in critical limb ischemia<...
Abstract 13185: Monocyte Specific Hydrogen Sulfide Regulates Arteriogenesis in Murine Hind Limb Ischemia | Circulation
Chronic Intestinal Ischaemia | definition of Chronic Intestinal Ischaemia by Medical dictionary
Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia :: Science Publishing Group
Estrogen deficiency attenuates neovascularization in a murine model of hindlimb ischemia<...
The Outcome of Percutaneous Transluminal Angioplasty in Patients with Critical Limb Ischemia and how Diabetes May Influence...
Always Contact a Vascular Interventional Specialist Before Amputating a Patient with Critical Limb Ischemia
Brain ischemia - Wikipedia
Trial of MarrowStim PAD Kit for the Treatment of Critical Limb Ischemia (CLI) in Subjects with Severe Peripheral Arterial...
Inserm - Observations on the perfusion recovery of regenerative angiogenesis in an ischemic limb model under hyperoxia
Acute lower limb ischemia in an ICU admitted patient diagnosed with covid 19: a case report - Authorea
Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery | World Journal of Emergency Surgery | Full Text
Advantages of myocardial revascularization after admission for critical limb ischemia in diabetic patients with coronary artery...
Contemporary (2009-2014) clinical outcomes after femoropopliteal bypass surgery for chronic limb threatening ischemia are...
SS1. Safety and Efficiacy of Rapid Autologous Bone Marrow Aspirate Concentrate for the Treatment of Critical Limb Ischemia in...
Spinal Cord Stimulation in the Treatment of Non-Reconstructable Stable Critical Leg Ischaemia: Results of the European...
YEUNGNAM UNIVERSITY: Cardiac risk factors of revascularization in chronic atherosclerotic lower extremity ischemia
Measurement of critical lower limb tissue hypoxia by coupling chemical and optical techniques. - Semantic Scholar
Fluoroscopy-guided simultaneous distal perfusion as a preventive strategy of limb ischemia in patients undergoing...
Human neural stem cells could meet the clinical problem of critical limb ischemia | Stem Cell News Digest
Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of...
First Czech Republic Diabetic Patient with Critical Limb Ischaemia Treated with Novel Regenerative Therapy by Associate...
Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1...
Constructing cost measures for critical limb ischemia<...
WCHQ - Ischemic Vascular Disease: Daily Aspirin or Other Antiplatelet Therapy Unless Contraindicated-Trend
WCHQ - Ischemic Vascular Disease: Daily Aspirin or Other Antiplatelet Therapy Unless Contraindicated-Trend
AHA Scientific Statement on Critical Limb Ischemia
Superior Mesenteric Arterial Embolism Associated with an Acute Limb Ischemia: A Case Report and Literature Review
Mesenteric ischemia in hemodialysis patients | NefrologÃa
JCI -
Reversal of postischemic acute renal failure with a selective endothelinA receptor antagonist in the rat.
Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice<...
Hypertensive kidney disease
Glomerular ischemia[edit]. High blood pressure in the long term can damage the endothelium, commonly known as the blood vessel ... with one theory identifying glomerular ischemia as the main contributor to HN and the other identifying glomerular hypertension ...
Hypoxia (medical)
Ischemia[edit]. Main article: Ischemia. Ischemia, meaning insufficient blood flow to a tissue, can also result in hypoxia. This ...
Thrombosis
Limb ischemia[edit]. An arterial thrombus or embolus can also form in the limbs, which can lead to acute limb ischemia.[6] ... in a feline model of intestinal ischemia, four hours of ischemia resulted in less injury than three hours of ischemia followed ... Targeting ischemia/reperfusion injury[edit]. Main article: Reperfusion injury. With reperfusion comes ischemia/reperfusion (IR ... Ischaemia/infarction: if an arterial thrombus cannot be lysed by the body and it does not embolise, and if the thrombus is ...
Electrocardiography
Ischemia and infarction[edit]. Main article: Electrocardiography in myocardial infarction. Ischemia or non-ST elevation ... It is usually isoelectric, but may be depressed or elevated with myocardial infarction or ischemia. ST depression can also be ... Inverted T waves can be a sign of myocardial ischemia, left ventricular hypertrophy, high intracranial pressure, or metabolic ...
Thrombosis
Limb ischemia[edit]. An arterial thrombus or embolus can also form in the limbs, which can lead to acute limb ischemia.[6] ... Ischaemia/infarction: if an arterial thrombus cannot be lysed by the body and it does not embolise, and if the thrombus is ... Creager, Mark A.; Kaufman, John A.; Conte, Michael S. (7 June 2012). "Acute Limb Ischemia". New England Journal of Medicine. ... This can be due to ischemia, thrombus, embolus (a lodged particle) or hemorrhage (a bleed). In thrombotic stroke, a thrombus ( ...
Prostaglandin E1
Critical limb ischemia[edit]. Prostanoids, including alprostadil, do not reduce the risk of limb amputation but may offer a ... "Prostanoids for critical limb ischaemia". Cochrane Database Syst Rev. 1: CD006544. doi:10.1002/14651858.CD006544.pub3. PMC ... slight improvement in rest-pain and leg ulcer healing in persons with critical limb ischemia.[11] ...
Heart failure with preserved ejection fraction
Ischemia[edit]. Ischemia, or inadequate oxygenation of the myocardium, is observed in a high proportion of HFpEF patients. This ... Ischemia may manifest in distinct ways, either as a result of increasing tissue oxygen demand, or diminished ability of the ... Ischemia can result in impaired relaxation of the heart; when myocytes fail to relax appropriately, myosin cross bridges remain ... development of ischemia, and atrial fibrillation. More specific to HFpEF include avoidance of preload reduction. As patients ...
Anasarca
Ischemia. *Brain ischemia. *Ischaemic heart disease. *large intestine: Ischemic colitis. *small intestine: Mesenteric ischemia ...
Pulmonary edema
Ischemia. *Brain ischemia. *Ischaemic heart disease. *large intestine: Ischemic colitis. *small intestine: Mesenteric ischemia ...
Cerebral edema
It can occur in Reye's syndrome, severe hypothermia, early ischemia, encephalopathy, early stroke or hypoxia, cardiac arrest, ... This type of edema may result from trauma, tumors, focal inflammation, late stages of cerebral ischemia and hypertensive ...
Myocardial scarring
"ISCHEMIA". Merriam-Webster. Retrieved 2020-03-23. Liang, Cuiping (2019). "Influence of the Distribution of Fibrosis within an ... Katz, Monica Y. (2014). "Three-Dimensional Myocardial Scarring along Myofibers after Coronary Ischemia-Reperfusion Revealed by ... Radauceanu, Anca (2007). "Residual Stress Ischemia Is Associated with Blood Markers of Myocardial Structural Remodeling". ...
Heme
Liepzig: Ischemia Verlagsgesellschaft.. *^ Puustinen A, Wikström M. (1991). "The heme groups of cytochrome o from Escherichia ...
Small intestine
Mesenteric ischemia. *Embolus or thrombus of the superior mesenteric artery or the superior mesenteric vein ...
Vascular surgery
Ischemia-repurfusion injuries of the appendicular musculoskeletal system. References[edit]. *^ Hooi JD; Kester AD; Stoffers HE ... Mesenteric ischemia. Surgical revascularization. Peripheral arterial occlusive disease. Angioplasty with/out Stenting Vascular ...
Meldonium
Myocardial ischemia. Mayo Clinic (25 July 2015). Retrieved on 28 May 2016. Zvejniece, L; Svalbe, B; Makrecka, M; Liepinsh, E; ... These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, ... "Meldonium cannot improve athletic performance, but it can stop tissue damage in the case of ischemia", the lack of blood flow ... It is primarily distributed in Eastern European countries as an anti-ischemia medication. Since 1 January 2016, it has been on ...
2021 in Panama
25 February - Frank Holness, 82, basketball player; cerebral ischemia. 2 March - Telma Barria Pinzón, diplomat (consul of ...
Traumatic brain injury
As a result, cerebral perfusion pressure (the pressure of blood flow in the brain) is reduced; ischemia results. When the ... Other factors in secondary injury are changes in the blood flow to the brain; ischemia (insufficient blood flow); cerebral ... Microdialysis allows ongoing sampling of extracellular fluid for analysis of metabolites that might indicate ischemia or brain ... and also ischemia-induced brain injury. In particular, it has been demonstrated through multiple studies to significantly ...
Near-death studies
... retinal ischemia; and processes linked to rapid eye-movement (REM) sleep or phenomena generated on the border between sleep and ...
Freezing tolerance
Ischemia tolerance:: in order for cells and organs to survive without circulation of the blood, good antioxidant defenses and ...
Cortical blindness
The most common cause of cortical blindness is ischemia (oxygen deprivation) to the occipital lobes caused by blockage to one ...
Thrombolysis
"Acute Limb Ischemia". The Lecturio Medical Concept Library. Retrieved 11 August 2021.. ... Angiograph before and after thrombolytic therapy in a case of acute limb ischemia. ...
Ulegyria
Cerebral ischemia occurs when the brain is not receiving adequate oxygen to continue normal functions. When this occurs, the ... Ischemia causes anoxic cell depolarizations and it is this increase in membrane potential at the presynaptic cell that triggers ... Ulegyria develops as a result of a brain injury called cerebral ischemia surrounding the time of an infant's birth. Oftentimes ... The cause of perinatal brain injuries includes: 1. cerebral ischemia 2. cerebral hemorrhage 3. ascending intrauterine ...
Ulrich Sigwart
Silent Myocardial Ischemia. Berlin: SpringerVerlag; 1984; 29-36 The SoS Investigators: Coronary artery bypass surgery versus ... he created the basis for the automated analysis of hemodynamic data and studied the repercussions of myocardial ischemia and ...
Circulating endothelial cell
This causes ischemia; the progressive death of cardiac muscle due to lack of oxygen. If the heart muscles have prolonged ... ischemia this may lead to the detachment of endocardial endothelial cells which can also create CEC. Studies have reported that ...
Adenosine receptor
cardioprotective in cardiac ischemia. *inhibition of neutrophil degranulation. *2-(1-Hexynyl)-N-methyladenosine ...
Christian J. Lambertsen
March 1961). "Cerebral ischemia and infarction". Am Pract Dig Treat. 12: 147-54. PMID 13777430.. CS1 maint: Uses authors ...
Nicolas Bazan
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim Biophys Acta 218:1-10, 1970 Bazan ... Implications in cerebral ischemia. Prog in Brain Res 96:247-257, 1993 Giusto NM, Bazan NG: Phosphatidic acid of retinal ... J Lipid Res 24:628-638, 1983 Aveldano MI, Bazan NG: Differential lipid deacylation during brain ischemia in a homeotherm and a ... Also, his laboratory found that the diacylglycerol accumulated in the brain during ischemia is derived from inositol lipids and ...
Pharmaceutical industry
Murphy BP, Stanton T, Dunn FG (May 2009). "Hypertension and myocardial ischemia". The Medical Clinics of North America. 93 (3 ...
Migrainous infarction
Cerebral ischaemia refers to a severely reduced flow of blood in the brain due to narrowing or blocking of arteries or blood ... Olesen, J.; Friberg, L.; Olsen, T. S.; Andersen, A. R.; Lassen, N. A.; Hansen, P. E.; Karle, A. (1993-02-01). "Ischaemia- ... Contrary to the suggestion that MA initiates ischaemic infarction, one theory suggests that ischaemia may in fact cause MA. ... PF4 promotes blood coagulation which can cause ischaemia, therefore, aspirin's ability to reduce PF4 concentration in people ...
Myocardial ischemia - Symptoms and causes - Mayo Clinic
Myocardial ischemia reduces blood flow to the heart and may cause chest pain - but not always. Learn all the signs and symptoms ... Causes of myocardial ischemia. Causes of myocardial ischemia. Myocardial ischemia occurs when blood flow to the heart muscle ( ... Myocardial ischemia, also called cardiac ischemia, reduces the heart muscles ability to pump blood. A sudden, severe blockage ... Coronary artery spasm is an uncommon cause of myocardial ischemia.. Chest pain associated with myocardial ischemia can be ...
Mesenteric ischemia - Wikipedia
non-occlusive ischemia: 73% mortality.. In the case of prompt diagnosis and therapy, acute mesenteric ischemia can be ... Mesenteric ischemia "should be suspected when individuals, especially those at high risk for acute mesenteric ischemia, develop ... As the cause of the ischemia can be due to embolic or thrombotic occlusion of the mesenteric vessels or nonocclusive ischemia, ... This article is about ischemia of the small bowel. For ischemia of the large bowel, see ischemic colitis. ...
Myocardial Ischemia
[A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).]
Ischemia | SpringerLink
E.J. Chung, M.I. Roh, O.W. Kwon, H.J. Koh, Effects of macular ischemia on the outcome of intravitreal bevacizumab therapy for ... N.N. Osborne, R.J. Casson, J.P.M. Wood, G. Childlow, M. Graham, J. Melena, Retinal ischemia: mechanisms of damage and potential ... "Ischemia" implies a tissue damage derived from perfusion insufficiency, not just an inadequate blood supply. Mild thickening ... G.D. Sturrock, H.R. Mueller, Chronic ocular ischaemia. Br. J. Ophthalmol. 68(10), 716-723 (1984)Google Scholar ...
Category:Ischemia - Wikimedia Commons
Media in category "Ischemia". The following 9 files are in this category, out of 9 total. ... ischemia restriction in blood supply to tissues, causing a shortage of oxygen and glucose ... MR-Angiography-of-Collateral-Arteries-in-a-Hind-Limb-Ischemia-Model-Comparison-between-Blood-Pool-pone.0016159.s003.ogv 9.9 s, ... MR-Angiography-of-Collateral-Arteries-in-a-Hind-Limb-Ischemia-Model-Comparison-between-Blood-Pool-pone.0016159.s004.ogv 14 s, ...
Necroptosis in Cerebral Ischemia | SpringerLink
Szydlowska K, Tymianski M (2010) Calcium, ischemia and excitotoxicity. Cell Calcium 47:122-129CrossRefPubMedGoogle Scholar ... Flynn RW, Macwalter RS, Doney AS (2008) The cost of cerebral ischaemia. Neuropharmacology 55:250-256CrossRefPubMedGoogle ... Qu Y, Shi J, Tang Y, Zhao F, Li S, Meng J, Tang J, Lin X, Peng X, Mu D (2016) MLKL inhibition attenuates hypoxia-ischemia ... Necroptosis Brain ischemia Receptor interacting protein kinase 1/3 Mixed lineage kinase domain-like (MLKL) Necrosome ...
Hepatic ischemia: MedlinePlus Medical Encyclopedia
Hepatic ischemia is a condition in which the liver does not get enough blood or oxygen. This causes injury to liver cells. ... Hepatic ischemia is a condition in which the liver does not get enough blood or oxygen. This causes injury to liver cells. ... Blood tests to check liver function (AST and ALT). These readings can be very high with ischemia. ... People generally recover if the illness causing hepatic ischemia can be treated. Death from liver failure due to hepatic ...
Acute limb ischaemia - Wikipedia
Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia ... Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. Acute limb ischaemia is caused by ... The New Latin term ischaemia as written, is a British version of the word ischemia, and stems from the Greek terms ischein to ... In the worst cases acute limb ischaemia progresses to critical limb ischaemia, and results in death or limb loss. Early ...
The Pharmacological Causes of Colon Ischemia
Which classes of medications are most commonly associated with drug-induced colon ischemia, and what are their respective ... Pharmacologic Agents Strongly Associated With Colon Ischaemia. *Pharmacologic Agents Moderately Associated With Colon Ischaemia ... Pharmacologic Agents Strongly Associated With Colon Ischaemia. *Pharmacologic Agents Moderately Associated With Colon Ischaemia ... Background: Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the ...
Mesenteric artery ischemia: MedlinePlus Medical Encyclopedia
Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply ... Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply ... People with acute mesenteric ischemia often do poorly because parts of the intestine may die before surgery can be done. This ... Symptoms of sudden (acute) mesenteric artery ischemia due to a traveling blood clot include:. *Sudden severe abdominal pain or ...
Mesenteric ischemia - Everything2.com
Mesenteric ischemia is a condition which refers to a low blood-flow state of one or more of the three arteries supplying the ... There are two forms of mesenteric ischemia: acute and chronic. Acute mesenteric ischemia generally causes sudden and severe ... Mesenteric ischemia is a condition which refers to a low blood-flow state of one or more of the three arteries supplying the ... Acute mesenteric ischemia, like strokes and heart attacks, is caused when one of the arteries is blocked by an embolism (blood ...
Acute mesenteric ischemia | CMAJ
... and nonocclusive ischemia.1 Nonocclusive ischemia occurs with splanchnic vasoconstriction, which can be caused by hypovolemia, ... Missed mesenteric ischemia is considered to have a mortality rate of 100%.2 The overall operative mortality rate is roughly 50% ... Acute mesenteric ischemia is caused by arterial insufficiency or venous obstruction. *The diagnosis is made most reliably with ... Acute mesenteric ischemia is caused by arterial insufficiency or venous obstruction. About half of all cases of acute ...
What Is Ischemia? What Causes Myocardial Ischemia?
Ischemia is a serious problem where some part of your body, like your heart or brain, isnt getting enough blood. Learn what ... Some people have silent ischemia in the heart or brain. This is when you have ischemia, but no pain or any other signs or ... Mayo Clinic: "Myocardial Ischemia," "Peripheral Artery Disease (PAD)," "Intestinal Ischemia," "Stroke," "Stress Management." ... You may hear it called ischemic heart disease, myocardial ischemia, or cardiac ischemia. ...
ISCHEMIA Trial: Was It Worth the Wait?
Ischemia-Reperfusion Injury and Anesthesia
... Guest Editors: Ahmet Eroglu, Engin Erturk, Can Ince, and Martin Westphal *Ischemia- ... Ischemia-Reperfusion Injury and Volatile Anesthetics, Engin Erturk Review Article (7 pages), Article ID 526301, Volume 2014 ( ... The Effect of Intravenous Anesthetics on Ischemia-Reperfusion Injury, Ahmet Eroglu Review Article (7 pages), Article ID 821513 ... The Effects of Spinal, Inhalation, and Total Intravenous Anesthetic Techniques on Ischemia-Reperfusion Injury in Arthroscopic ...
Treating Cerebral Ischemia
For treating cerebral ischemia/reperfusion, mesenchymal stem cell transplantation is a novel means and can promote angiogenesis ... Research Explores Use of Salvianolate for Treatment of Cerebral Ischemia-Reperfusion Injuries. Previous research has shown that ... Tau Protein Phosphorylation in Rats Subjected to Cerebral Ischemia-reperfusion Injury Hyperphosphorylation of the microtu-bule- ... For treating cerebral ischemia/reperfusion, mesenchymal stem cell transplantation is a novel means and can promote angiogenesis ...
Hand ischemia after radial artery cannulation. - PubMed - NCBI
Mean (+/- SD) duration of radial artery ischemia was 3 +/- 2 days. Injuries were associated with advanced (grade IIb) ischemia ... Hand ischemia after radial artery cannulation.. Valentine RJ1, Modrall JG, Clagett GP. ... Hand ischemia is a rare but potentially devastating complication of radial artery cannulation for arterial monitoring. The ... These data show that hand ischemia after radial artery cannulation is associated with high risk of tissue loss or amputation. ...
Experimental antileukocyte interventions in cerebral ischemia. - PubMed - NCBI
Experimental antileukocyte interventions in cerebral ischemia.. Härtl R1, Schürer L, Schmid-Schönbein GW, del Zoppo GJ. ... The role of WBCs has been investigated in a great variety of global and focal cerebral ischemia models with and without ... could also act as mediators of secondary brain damage in the setting of focal and global cerebral ischemia with and without ... and the power of evidence they provide for identification of WBCs as important factors in cerebral ischemia. ...
ECG tutorial: Myocardial ischemia and infarction
In order to recognize abnormalities that suggest ischemia or infarction, it is imp ... is an important test used in the clinical evaluation of patients with suspected or known myocardial ischemia or myocardial ... ECG tutorial: Myocardial ischemia and infarction. Author. Jordan M Prutkin, MD, MHS, FHRS. Jordan M Prutkin, MD, MHS, FHRS ... Electrocardiogram in the diagnosis of myocardial ischemia and infarction. *Pathogenesis and diagnosis of Q waves on the ...
What Is Inferior Ischemia? | Reference.com
Inferior ischemia is a condition that affects the inferior myocardial wall, which is caused by the occlusion of the coronary ... Also called myocardial ischemia or cardiac ischemia, inferior ischemia can lead to serious unusual heart rhythms in patients, ... Inferior ischemia is a condition that affects the inferior myocardial wall, which is caused by the occlusion of the coronary ...
Intestinal ischemia Risk factors - Mayo Clinic
Colon ischemia (ischemic colitis). This most common type of intestinal ischemia occurs when blood flow to the colon is slowed. ... Acute mesenteric ischemia. This type of intestinal ischemia usually affects the small intestine. It has an abrupt onset and may ... Chronic mesenteric ischemia. Chronic mesenteric ischemia, also known as intestinal angina, results from the buildup of fatty ... You may hear this type of acute mesenteric ischemia referred to as nonocclusive ischemia, which means that its not due to a ...
Patent US7181268 - Ischemia detection - Google Patents
The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and ... both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in ... pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia ... Techniques for detection and treatment of myocardial ischemia are described that monitor ...
Plus it
Plus it
Mesenteric Ischemia
... , Acute Mesenteric Ischemia, Mesenteric Infarction, Colonic Ischemia, Intestinal Ischemia, Colonic ... Vasculitis, Ischemic Colitis, Visceral Artery Ischemia, Acute Intestinal Vascular Insufficiency, Acute Ischemic Enteritis. ... Mesenteric Ischemia. search Mesenteric Ischemia, Acute Mesenteric Ischemia, Mesenteric Infarction, Colonic Ischemia, Intestinal ... Sepsis and Ischemia related labs. *Lactic Acid (marker of bower ischemia or infarction). *Normal Lactic Acid dose not exclude ...
Nuvelo: Phase II anticoagulant shown to reduce ischemia - MarketWatch
Nonocclusive Mesenteric Ischemia Associated with Ogilvie Syndrome
... Takashi Sakamoto,1,2 Toshiyuki Suganuma,2 Shinichiro Okada,2 ... J. L. Bobadilla, "Mesenteric ischemia," Surgical Clinics of North America, vol. 93, no. 4, pp. 925-940, 2013. View at Publisher ... J. S. Michael, "Acute mesenteric ischemia," Surgical Clinics of North America, vol. 94, no. 1, pp. 165-181, 2014. View at ... L. J. Brandt and S. J. Boley, "AGA technical review on intestinal ischemia," Gastroenterology, vol. 118, no. 5, pp. 954-968, ...
ischemia - Symptoms, Treatments and Resources for ischemia
Treatments and Tools for ischemia. Find ischemia information, treatments for ischemia and ischemia symptoms. ... ischemia - MedHelps ischemia Center for Information, Symptoms, Resources, ... Hi; I am post Hemi-RVO,& have developed a small area of Peripheral Ischemia. I was given ... ... My ECG revealed lateral ischemia. I dont have health insurance anymore and therefore have... ...
PRESSURE MEASUREMENT-BASED ISCHEMIA DETECTION - PACESETTER, INC.
For example, ischemia may be indicated based on an increase in an intraventricular electromechanical delay where mechanica ... In some aspects ischemia is indicated based on cardiac pressure measurements. ... During ischemia there may be a rise in mean left atrial pressure as well as a high occurrence of ischemia-induced mitral valve ... Ischemia may be indicated based on a change in a time interval associated with a systolic interval of a ventricle. Ischemia ...
What is chronic brain ischemia? | Reference.com
Cerebral or brain ischemia occurs when there is not enough blood flow to the brain. This reduction in blood flow restricts ... Brain ischemia may be categorized as focal ischemia or global ischemia, and the cause for ischemia can range from congenital ... What is microvascular ischemia?. A: Microvascular ischemia is a condition associated with reduced blood flow in some areas of ... Focal ischemia is generally caused by embolism or thrombosis. Global ischemia covers wide portions of the brain and occurs when ...
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Limb ischemia28
- When a limb is ischemic in the non-acute (chronic) setting, the condition is alternatively called peripheral artery disease or critical limb ischemia, rather than ALI. (wikipedia.org)
- In addition to limb ischemia, other organs can become ischemic, causing: Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia there are a series of things that can be done to determine where the occlusion is located, the severity, and what the cause was. (wikipedia.org)
- Doctors call this "critical limb ischemia. (webmd.com)
- Clinical manifestations of acute limb ischemia (which can be summarized as the "six P's") include pain, pallor, pulseless, paresthesia, paralysis, and poikilothermia. (wikipedia.org)
- Lack of blood flow to a limb results in acute limb ischemia. (wikipedia.org)
- In patients with critical limb ischemia (CLI) and foot ulcers wound healing is an important goal which can normally only be achieved after sufficient treatment of the underlying ischemia (revascularization either by an operation, e. g. bypass, or a catheter intervention). (clinicaltrials.gov)
- Endovascular therapy has overtaken surgical revascularization for the treatment of critical limb ischemia -- with implications for outcomes, a study found. (medpagetoday.com)
- While the annual rate of critical limb ischemia admissions remained constant between 2003 and 2011, the proportion getting endovascular treatments during those hospitalizations rose from 5.1% in 2003 to 11.0% in 2011. (medpagetoday.com)
- The data came from 642,433 U.S. admissions in the Nationwide Inpatient Sample with administrative codes indicating critical limb ischemia, projected to represent nearly 3 million admissions for the condition nationally, from 2003 through 2011. (medpagetoday.com)
- In this issue of Circulation , Powell et al 17 report on the safety and bioactivity profile of hepatocyte growth factor (HGF) plasmid injection for critical limb ischemia (CLI). (ahajournals.org)
- Critical limb ischemia (CLI) is a severe blockage in the arteries of the lower extremities, which markedly reduces blood-flow. (ucdavis.edu)
- The most prominent features of critical limb ischemia (CLI) are called ischemic rest pain - severe pain in the legs and feet while a person is not moving, or non-healing sores on the feet or legs. (ucdavis.edu)
- Risk factors for chronic limb ischemia are the same as those for atherosclerosis, hardening and narrowing of the arteries due to the build up of fatty deposits, called plaque. (ucdavis.edu)
- Critical limb ischemia is a serious condition that requires immediate treatment to re-establish blood-flow to the affected area. (ucdavis.edu)
- legs (critical limb ischemia - a form of peripheral artery disease ), and intestines (acute mesenteric ischemia or bowel ischemia). (emedicinehealth.com)
- Vascular Endothelial Growth Factor (VEGF) or placebo in patients with moderate to high-risk Critical Limb Ischemia (a condition in which there is poor blood circulation in the leg). (bioportfolio.com)
- The purpose of this study is to evaluate whether intramuscular injections of VM202 into the calf is safe and effective in the treatment of critical limb ischemia. (bioportfolio.com)
- The purpose of this study is to determine the safety, tolerability and preliminary efficacy of intramuscular injections of VM202 for subjects with critical limb ischemia. (bioportfolio.com)
- This is an Expanded Access program (EAP), sponsored by WideTrial for the treatment of critical limb ischemia (CLI). (bioportfolio.com)
- Endovascular first strategy for critical limb ischemia is widely accepted, because of the increasing patency rates and minimal invasive character, especially in elderly patients. (bioportfolio.com)
- Treatment of Nonreconstructable Critical Limb Ischemia With Ischemic Wounds Utilizing a Noninvasive Intermittent Pneumatic Compression Device Monitored With Fluorescence Angiography. (bioportfolio.com)
- Critical limb ischemia (CLI) is a leading cause of lower extremity amputation. (bioportfolio.com)
- Emergency Department Utilization after Lower Extremity Bypass for Critical Limb Ischemia. (bioportfolio.com)
- Patients with critical limb ischemia (CLI) utilize hospital resources at high rates. (bioportfolio.com)
- Utility of indigo carmine angiography in patients with critical limb ischemia: Prospective multi-center intervention study (DIESEL-study). (bioportfolio.com)
- To assess the efficacy of indigo carmine angiography for wound healing after successful below-the-knee intervention in patients with critical limb ischemia (CLI). (bioportfolio.com)
- Computed tomography angiography evaluation of acute limb ischemia. (bioportfolio.com)
- Acute limb ischemia (ALI), a subclass of critical limb ischemia, is a medical emergency. (bioportfolio.com)
Intestinal20
- Intestinal ischemia (is-KEE-me-uh) describes a variety of conditions that occur when blood flow to your intestines decreases due to a blockage, usually in an artery. (mayoclinic.org)
- Intestinal ischemia can affect your small intestine, your large intestine (colon) or both. (mayoclinic.org)
- Intestinal ischemia is a serious condition that can cause pain and make it difficult for your intestines to work. (mayoclinic.org)
- Treatments are available for intestinal ischemia. (mayoclinic.org)
- Signs and symptoms of intestinal ischemia can develop suddenly (acute) or gradually (chronic). (mayoclinic.org)
- The condition presents differently in different people, so no one set of signs and symptoms indicates intestinal ischemia, but there are some generally recognized patterns. (mayoclinic.org)
- Intestinal ischemia occurs when the blood flow through the major arteries that supply blood to your intestines slows or stops. (mayoclinic.org)
- If untreated, intestinal ischemia can be fatal. (mayoclinic.org)
- This most common type of intestinal ischemia occurs when blood flow to the colon is slowed. (mayoclinic.org)
- This type of intestinal ischemia usually affects the small intestine. (mayoclinic.org)
- This type of sudden ischemia tends to occur in people with chronic intestinal ischemia. (mayoclinic.org)
- Acute intestinal ischaemia. (bmj.com)
- Welch M . Acute intestinal ischaemia. (bmj.com)
- Chronic mesenteric ischemia, also referred to as intestinal ischemia occurs when plaque builds up in the major arteries that supply blood to the small intestine or small bowel. (upmc.com)
- Surgery isn't always necessary if intestinal ischemia progresses slowly. (healthline.com)
- Carnosol pretreatment attenuates liver injury induced by intestinal ischemia reperfusion. (greenmedinfo.com)
- Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion. (greenmedinfo.com)
- Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice. (greenmedinfo.com)
- Ginsenoside Rg1 could exert its therapeutic effects on intestinal intestinal ischemia/reperfusion injury. (greenmedinfo.com)
- Nigella Sativa treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury. (greenmedinfo.com)
Silent ischemia8
- Some people who have myocardial ischemia don't have any signs or symptoms (silent ischemia). (mayoclinic.org)
- Some people have silent ischemia in the heart or brain . (webmd.com)
- What is the definition of silent ischemia? (webmd.com)
- Silent ischemia is a condition in which an inadequate supply of oxygen-rich blood to the heart does not cause symptoms such as chest pain. (webmd.com)
- This is called silent ischemia. (clevelandclinic.org)
- Ischemia in the heart and brain often causes no symptoms, and is sometimes referred to as "silent ischemia," and the first sign may be an unexpected heart attack or stroke . (emedicinehealth.com)
- RESULTS -A total of 113 patients (22%) had silent ischemia, including 83 with regional myocardial perfusion abnormalities and 30 with normal perfusion but other abnormalities (i.e., adenosine-induced ST-segment depression, ventricular dilation, or rest ventricular dysfunction). (diabetesjournals.org)
- Selecting only patients who met American Diabetes Association guidelines would have failed to identify 41% of patients with silent ischemia. (diabetesjournals.org)
Cardiac ischemia12
- Myocardial ischemia, also called cardiac ischemia, reduces the heart muscle's ability to pump blood. (mayoclinic.org)
- You may hear it called ischemic heart disease , myocardial ischemia, or cardiac ischemia. (webmd.com)
- Also called myocardial ischemia or cardiac ischemia, inferior ischemia can lead to serious unusual heart rhythms in patients, as stated by the Mayo Clinic. (reference.com)
- To determine whether episodes of hypoglycemia were more likely to be associated with cardiac ischemia than normoglycemia or hyperglycemia, we carried out a study in 21 patients with coronary artery disease (CAD) and type 2 diabetes treated with insulin who had good glycemic control. (diabetesjournals.org)
- Patients also recorded symptoms of cardiac ischemia (chest pain) and symptoms of hypoglycemia. (diabetesjournals.org)
- CONCLUSIONS -Hypoglycemia is more likely to be associated with cardiac ischemia and symptoms than normoglycemia and hyperglycemia, and it is particularly common in patients who experience considerable swings in blood glucose. (diabetesjournals.org)
- Although the literature is replete with anecdotal cases of hypoglycemia-triggered cardiac events, it has previously been difficult to document an association between hypoglycemia and cardiac ischemia in humans ( 7 , 8 ). (diabetesjournals.org)
- With the availability of a continuous glucose sensor, combined with continuous ECG monitoring, new technologies make it possible to examine relationships between hypoglycemia and cardiac ischemia ( 12 , 13 ). (diabetesjournals.org)
- Cardiac ischemia may be asymptomatic or may cause chest pain, known as angina pectoris. (wikipedia.org)
- Coronary ischemia, myocardial ischemia, or cardiac ischemia, is a medical term for a reduced blood flow in the coronary circulation through the coronary arteries. (wikipedia.org)
- Cardiac ischemia also called (ischemic heart disease and myocardial ischemia) is decreased blood flow and oxygen to the heart muscle. (emedicinehealth.com)
- Current therapies of cardiac ischemia, myocardial infarction (MI) and heart failure, aiming to preserve and improve ventricular function and clinical outcomes, include pharmacological interventions, surgical procedures, or mechanical left ventricular assist devices. (frontiersin.org)
Severe16
- The clot might block an artery and lead to sudden, severe myocardial ischemia, resulting in a heart attack. (mayoclinic.org)
- Acute mesenteric ischemia generally causes sudden and severe abdominal pain , often associated with vomiting and diarrhea . (everything2.com)
- In the light of currently available data, it seems likely that WBCs contribute to secondary brain damage in the scenario of experimental transient focal cerebral ischemia, if the insult is not too severe. (nih.gov)
- Global ischemia is often the result of cardiac arrest, and if left untreated for too long, may result in severe brain damage, explains the Columbia University Medical Center. (reference.com)
- In severe cases, brain ischemia may result in irreversible brain damage, stroke or cardiac arrest. (reference.com)
- Acute ischemia has severe symptoms. (healthline.com)
- Severe head trauma can also result in ischemia by rupturing or crushing vessels to prevent blood from reaching some areas of the brain. (wisegeek.com)
- Before, during, and after this period of severe ischemia, studies of the perfor- mance of the myocardium at risk can be carried out. (springer.com)
- Other projects study the interventions that may protect cardiac muscle and vascular endothelium from severe damage in ischemia / reperfusion and may thus improve the chances for recovery upon successful intervention. (uni-giessen.de)
- Here, we report that transient cerebral ischemia caused severe protein aggregation in hippocampal CA1 neurons. (jneurosci.org)
- In the double-blind, placebo-controlled, dose-escalating, multicenter HGF-STAT Trial, 104 patients with rest pain or tissue loss due to severe lower-extremity ischemia were assigned to receive injections of placebo or 1 of 3 dosing regimens of HGF plasmid into the ischemic leg muscle. (ahajournals.org)
- The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
- Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
- citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
- Ischemia in the small intestine interferes with digestion and can cause severe abdominal pain. (hopkinsmedicine.org)
- The aim of the study is in a phase I safety study to evaluate the clinical effect of autologous mesenchymal stem cell therapy in patients with severe chronic myocardial ischemia.10 patients with reversible ischemia on a SPECT will be treated with direct intramyocardial injections of autologous isolated and expanded mesenchymal stem cells.Clinical and objective evaluations will be performed at baseline and during 24 months follow-up. (clinicaltrials.gov)
Occurs17
- Myocardial ischemia occurs when blood flow to the heart muscle (myocardium) is obstructed by a partial or complete blockage of a coronary artery by a buildup of plaques (atherosclerosis). (mayoclinic.org)
- Myocardial ischemia occurs when blood flow to your heart is reduced, preventing the heart muscle from receiving enough oxygen. (mayoclinic.org)
- Myocardial ischemia occurs when the blood flow through one or more of your coronary arteries is decreased. (mayoclinic.org)
- Mesenteric ischemia is a medical condition in which injury to the small intestine occurs due to not enough blood supply. (wikipedia.org)
- Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. (wikipedia.org)
- Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply the small and large intestines. (medlineplus.gov)
- Mortality rates climb significantly if peritonitis occurs due to ischemia. (everything2.com)
- 1 Nonocclusive ischemia occurs with splanchnic vasoconstriction, which can be caused by hypovolemia, hypotension, decreased cardiac output and exogenous vasopressors. (cmaj.ca)
- Cerebral or brain ischemia occurs when there is not enough blood flow to the brain. (reference.com)
- Focal ischemia is isolated to a particular region of the brain and occurs when a brain vessel is blocked by the formation of a blood clot. (reference.com)
- Global ischemia covers wide portions of the brain and occurs when blood flow to the brain is severely reduced or stopped. (reference.com)
- The goal of chronic mesenteric ischemia treatment is to restore blood flow to your intestines before damage occurs. (upmc.com)
- Coronary artery disease (CAD) occurs when fatty substances, known as plaques, adhere to the walls of coronary arteries supplying the heart, narrowing them and constricting blood flow, a process known as atherosclerosis, the most common cause of coronary ischemia. (wikipedia.org)
- Mesenteric ischemia occurs when any of the mesenteric arteries, which supply blood to the intestines, are constricted. (hopkinsmedicine.org)
- CONCLUSIONS -Silent myocardial ischemia occurs in greater than one in five asymptomatic patients with type 2 diabetes. (diabetesjournals.org)
- When doctors at the hospital performed a 12-channel ECG, it revealed "no evidence for ischemia," which occurs when blood flow to the heart is reduced, preventing the heart muscle from receiving enough oxygen. (macrumors.com)
- There is ample evidence to suggest that apoptosis, in addition to coagulation necrosis, contributes to the neuronal cell death that occurs after brain ischemia 6 . (nature.com)
Atherosclerosis9
- Atherosclerosis is the most common cause of myocardial ischemia. (mayoclinic.org)
- One of the main causes of ischemia is atherosclerosis . (webmd.com)
- Atherosclerosis (hardening of the arteries) causes chronic mesenteric ischemia. (upmc.com)
- Atherosclerosis is usually the cause of chronic ischemia. (healthline.com)
- The relationship of exercise ECG myocardial ischemia to the presence of carotid atherosclerosis and to carotid and left ventricular structure and function was examined in a population of 204 asymptomatic subjects free of clinical evidence of cardiovascular disease. (ahajournals.org)
- Although the subjects in our study were on average 15 to 20 years younger than the subjects examined by Nagai et al, 1 the findings from the 2 studies are remarkably similar with respect to the associations between ECG evidence of ischemia and carotid atherosclerosis, thus extending these observations to nearly the entire adult life span. (ahajournals.org)
- 4 Together with the increased cardiac morbidity and mortality associated with abnormal HR-adjusted ST-segment depression indexes, 5 these findings suggest that asymptomatic individuals with carotid thickening due to atherosclerosis or hypertrophy and exercise-induced ischemia may be at a substantially increased risk of future coronary events. (ahajournals.org)
- Despite progressive insights into the pathologies underlying coronary, cerebral, and peripheral artery atherosclerosis, these conditions continue to cause critical tissue ischemia and disability on an epidemic scale. (ahajournals.org)
- A primary cause of ischemia is atherosclerosis ( hardening of the arteries ). (emedicinehealth.com)
Ischemic colitis2
- For ischemia of the large bowel, see ischemic colitis . (wikipedia.org)
- Ischemia of the large intestine may result in an inflammatory process known as ischemic colitis. (wikipedia.org)
Stroke10
- What is ischemia stroke? (patientslikeme.com)
- Data from patients with ischemia stroke, who reported starting treatments within the last 5 years. (patientslikeme.com)
- A brief episode of ischemia affecting the brain is called a transient ischemic attack (TIA), often called a mini-stroke. (wikipedia.org)
- Other effects that may result from brain ischemia are stroke, cardiorespiratory arrest, and irreversible brain damage. (wikipedia.org)
- Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
- There are two major mechanisms causing brain damage in stroke patients: Hemorrhage and Ischemia which represents about 70% to 80% of all strokes' cases. (scirp.org)
- Ischemia in brain tissue, for example due to stroke or head injury , causes a process called the ischemic cascade to be unleashed, in which proteolytic enzymes , reactive oxygen species , and other harmful chemicals damage and may ultimately kill brain tissue. (wikidoc.org)
- Innate immune signaling is important in the pathophysiology of ischemia/reperfusion (stroke) induced injury and recovery. (jneurosci.org)
- Innate immune responses are critical in stroke pathophysiology, and microglia are key cellular effectors in the CNS response to ischemia/reperfusion. (jneurosci.org)
- These findings present strong evidence that Fas ligand/receptor pathway promotes cell death following brain ischemia and inhibition of Fas ligand/receptor interaction may provide significant neuroprotection affording a new treatment modality in ischemic stroke injury. (nature.com)
Abdominal pain1
- Signs and symptoms of colon ischemia include rectal bleeding and the sudden onset of mild, crampy abdominal pain. (mayoclinic.org)
Blockage3
- You usually get ischemia because of a build-up or blockage in your arteries. (webmd.com)
- citation needed] Blockage of arteries due to plaque buildup may also result in ischemia. (wikipedia.org)
- Ischemia can also be described as an inadequate flow of blood to a part of the body, caused by constriction or blockage of the blood vessels supplying it. (wikidoc.org)
Mechanisms5
- To review comprehensively the literature regarding the pharmacological aetiologies of colonic ischaemia to enhance the understanding of the various mechanisms of disease, presentations, distribution, and outcomes. (medscape.com)
- Schematic of mechanisms implicated in ischemia-induced neuronal death (in red) and the development of ischemic tolerance (in blue) in the brain. (jci.org)
- We believe this new template may be important because it's showing different mechanisms of action-different ways to interact with neurons, possibly with a good therapeutic effect for such diseases as epilepsy, hypoxia-ischemia and several neurodegenerative disorders," said Alban Pereira, a postdoctoral researcher in Scripps' CMBB. (acronymfinder.com)
- In this study, six ginsenosides, namely ginsenoside Rb1, Rh2, Rg3, Rg5 as diol-type ginseng saponins, and Rg1 and Re as triol-type ginseng saponins, which were reported to be effective for ischemia-reperfusion (I/R) treatment, were chosen to compare their protective effects on cerebral I/R injury, and their mechanisms were studied by in vitro and in vivo experiments. (mdpi.com)
- We have also elucidated several novel ischemia/reperfusion-induced microglial signaling mechanisms. (jneurosci.org)
Revascularization3
- We hypothesize that digital gangrene results from distal embolization from the site of the initial arterial thrombosis, producing ischemia that is not remediated by radial artery revascularization. (nih.gov)
- Note that patients without hemodynamic ischemia by FFR who were followed on optimal medical therapy had a revascularization rate similar to the stented patients in the randomized part of the trial. (medpagetoday.com)
- PARIS -- For patients with proven ischemia, stenting substantially cuts the revascularization rate compared with optimal medical therapy alone, preliminary trial results showed. (medpagetoday.com)
Therapeutic10
- Ischemia Reperfusion Injury - Pipeline Review, H2 2015 Summary Global Markets Direct s, Ischemia Reperfusion Injury - Pipeline Review, H2 2015, provides an overview of the Ischemia Reperfusion Injurys therapeutic pipeline. (mynewsdesk.com)
- This report provides comprehensive information on the therapeutic development for Ischemia Reperfusion Injury, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (mynewsdesk.com)
- It also reviews key players involved in the therapeutic development for Ischemia Reperfusion Injury and special features on late-stage and discontinued projects. (mynewsdesk.com)
- Recent technological advances in neuroimaging offer important insights into acute ischemia, yet numerous questions abound and evidence to support innovative therapeutic interventions is lacking. (lovereading.co.uk)
- Diagnostic strategies may identify larger populations for acute treatment, tailor therapeutic approaches to specific individuals, delineate novel therapeutic targets, and enhance management of each patient at successive stages of ischemia. (lovereading.co.uk)
- All of these topics on diagnostic strategies are considered with respect to the ultimate objective of broadening current therapeutic strategies for ischemia. (lovereading.co.uk)
- Boston, MA -- ( SBWIRE ) -- 08/14/2013 -- Global Markets Direct's, 'Ischemia - Pipeline Review, H2 2013', provides an overview of the indication's therapeutic pipeline. (sbwire.com)
- This report provides information on the therapeutic development for Ischemia, complete with latest updates, and special features on late-stage and discontinued projects. (sbwire.com)
- It also reviews key players involved in the therapeutic development for Ischemia. (sbwire.com)
- A snapshot of the global therapeutic scenario for Ischemia. (sbwire.com)
Method for detecting myocardia1
- An apparatus and method for detecting myocardial ischemia in a subject monitors the systemic vascular resistance of the subject and detects the presence of myocardial ischemia when the systemic vascular resistance increases by at least sixty percent over a base line value. (google.es)
Diagnosis of acute mesenteric ischemia2
- Often, the definitive diagnosis of acute mesenteric ischemia cannot be made clinically because of its nonspecific presentation and variable findings on physical examination. (cmaj.ca)
- The constellation of these findings on CT imaging yields high sensitivity and specificity for the diagnosis of acute mesenteric ischemia. (appliedradiology.com)
Arteries11
- Myocardial ischemia can develop slowly as arteries become blocked over time. (mayoclinic.org)
- A Doppler evaluation is used to show the extent and severity of the ischaemia by showing flow in smaller arteries. (wikipedia.org)
- Mesenteric ischemia is a condition which refers to a low blood-flow state of one or more of the three arteries supplying the digestive tract . (everything2.com)
- Acute mesenteric ischemia, like strokes and heart attacks , is caused when one of the arteries is blocked by an embolism (blood clot), or thromboses . (everything2.com)
- Chronic mesenteric ischemia is a condition in which plaque builds up in the major arteries - including the celiac and superior mesenteric arteries - that supply blood to the small intestine or small bowel. (upmc.com)
- High cholesterol contributes to the ischemia because it causes plaque to line your arteries. (healthline.com)
- Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
- Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
- Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts.Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
- citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
- Occlusion of coronary arteries induces ischemia followed by rapid upregulation of pro-inflammatory cytokines, increased oxidative stress and MMP2 activity, leading to an enhanced apoptosis of cardiac myocytes. (frontiersin.org)
Neuronal4
- Dr. Wei Lu and his team from the Second Xiangya Hospital, Central South University, China found that administration of salvianolate during reperfusion after ischemia appears to attenuate brain tissue damage and inhibit neuronal apoptosis by increasing heat shock protein 22 and phosphorylated protein kinase B expression. (eurekalert.org)
- This study, which has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), suggest that ginsenoside Rb1 is a promising candidate for clinical use in the prevention of neuronal degeneration following cerebral ischemia. (news-medical.net)
- Neuroglobin (Ngb), a protein related to myoglobin and hemoglobin but expressed predominantly in the brain, is induced by neuronal hypoxia and cerebral ischemia and protects against hypoxic or ischemic neuronal injury. (pnas.org)
- A single intranasal administration of 2 mg/kg FBP resulted in significantly reduced neuronal cell death by inhibiting Fas-mediated apoptosis leading to decreased infarct volumes, reduced neurologic deficit scores and recovery from cerebral ischemia. (nature.com)
Bowel ischemia4
- In contrast, patients with an acute thromboembolism are more likely to develop bowel ischemia, since they have not developed collaterals. (appliedradiology.com)
- Because of venous congestion, bowel ischemia is more likely to demonstrate bowel-wall thickening, mucosal hyper-enhancement, and mesenteric edema, which can be either hypo- or hyperdense depending on whether edema or hemorrhage is prevalent. (appliedradiology.com)
- 8 Conversely, bowel ischemia resulting from arterial thromboembolism is actually associated with bowel-wall thinning and no mucosal enhancement in the early stages. (appliedradiology.com)
- 12,13 Ultimately, as bowel ischemia progresses to infarction, the conventional signs of reactive edema become progressively more apparent regardless of whether venous or arterial occlusion is the culprit (Figure 5). (appliedradiology.com)
Reperfusion-induced4
- Punicalagin pre-treatment could protect against ischemia/reperfusion induced oxidative stress and myocardial injury via activation of AMPK. (greenmedinfo.com)
- Recent work has identified Toll-like receptors (TLRs) and type I interferon (IFN) signaling in both ischemia/reperfusion-induced brain injury and ischemic preconditioning-mediated neuroprotection. (jneurosci.org)
- We confirmed both in vitro H/H-N/N- and in vivo ischemia/reperfusion-induced microglial ISG responses by quantitative real-time PCR and demonstrated that both were dependent on IFNAR1. (jneurosci.org)
- Taken together, these data suggest novel ischemia/reperfusion-induced pathways for both TLR4-dependent and -independent, IFNAR1-dependent, type 1 IFN signaling in microglia. (jneurosci.org)
Detection7
- Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. (google.com.au)
- The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection. (google.com.au)
- Ischemia detection also may involve obtaining timing information relating to a mechanical contraction of at least one ventricle to identify an intraventricular dyssynchrony. (freepatentsonline.com)
- Due in part to the National Heart Lung and Blood Institute's emphasis on promoting research on rapid detection of the symptoms of acute myocardial ischemia, various types of biosensor designs, including ion-selective optical fibers, wave-guides, nanoparticle fluorescence sensors and ion-selective electrodes, have been used to detect potassium and hydrogen in the blood stream. (medgadget.com)
- RESEARCH DESIGN AND METHODS -In the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study, 1,123 patients with type 2 diabetes, aged 50-75 years, with no known or suspected coronary artery disease, were randomly assigned to either stress testing and 5-year clinical follow-up or to follow-up only. (diabetesjournals.org)
- The Detection of Ischemia in Asymptomatic Diabetics (DIAD) study was designed to determine the prevalence and severity of inducible myocardial ischemia in asymptomatic patients with type 2 diabetes, using adenosine-stress single-photon emission-computed tomography (SPECT) myocardial perfusion imaging as well as clinical and laboratory predictors of abnormal test results. (diabetesjournals.org)
- In July 2004, the Food and Drug Administration (FDA) approved the CardioMag Imaging MCG as a safe device for the non-invasive detection of ischemia. (wikidoc.org)
Focal6
- Recently, increasing interest has been directed toward the question of whether WBCs, particularly polymorphonuclear leukocytes, could also act as mediators of secondary brain damage in the setting of focal and global cerebral ischemia with and without reperfusion. (nih.gov)
- The role of WBCs has been investigated in a great variety of global and focal cerebral ischemia models with and without reperfusion, leading to sometimes contradictory results. (nih.gov)
- Brain ischemia may be categorized as focal ischemia or global ischemia, and the cause for ischemia can range from congenital heart defects to sickle cell anemia. (reference.com)
- Focal ischemia is generally caused by embolism or thrombosis. (reference.com)
- In studies on rats subjected to focal cerebral ischemia induced by middle cerebral artery (MCA) occlusion ( 16 ), intraventricular administration of a Ngb antisense oligonucleotide increased infarct volume and associated neurological deficits, whereas a Ngb-expressing adeno-associated vector, delivered intracerebrally, reduced infarct size and neurological impairment. (pnas.org)
- Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery of FBP after middle cerebral artery occlusion (MCAO) surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. (nature.com)
Gangrene4
- In some cases, gangrene can occur within six hours of ischaemia. (wikipedia.org)
- 2 The overall operative mortality rate is roughly 50% 2 and varies depending on such factors as the extent of gangrene, length of resection and reversibility of the ischemia. (cmaj.ca)
- Regardless of patency, all patients who survived arterial repairs had continuing ischemia that resulted in digital gangrene or amputation. (nih.gov)
- Without immediate intervention, ischemia may progress quickly to tissue necrosis and gangrene within a few hours. (wikipedia.org)
Embolism2
- Acute limb ischaemia is caused by embolism or thrombosis, or rarely by dissection or trauma. (wikipedia.org)
- About half of all cases of acute mesenteric ischemia are caused by arterial embolism originating from a cardiac source. (cmaj.ca)
Vascular8
- At UPMC, experts from the Division of Vascular Surgery handle the treatment of chronic mesenteric ischemia. (upmc.com)
- UPMC's Vascular Surgery Division has access to the latest minimally invasive treatments for chronic mesenteric ischemia. (upmc.com)
- A leader in the treatment of chronic mesenteric ischemia, UPMC is actively engaged in research in an effort to improve outcomes for our complex vascular patients. (upmc.com)
- Chronic ischemia of the brain may result in a form of dementia called vascular dementia. (wikipedia.org)
- Ischemia is a vascular disease involving an interruption in the arterial blood supply to a tissue, organ, or extremity that, if untreated, can lead to tissue death. (wikipedia.org)
- detecting the presence of myocardial ischemia in a subject when the monitored systemic vascular resistance of the subject increases by at least 60%, thereby indicating the presence of myocardial ischemia. (google.es)
- Why choose Johns Hopkins Heart and Vascular Institute for treatment of mesenteric ischemia? (hopkinsmedicine.org)
- Our vascular surgeons are at the forefront of minimally invasive treatments for mesenteric ischemia. (hopkinsmedicine.org)
Inadequate6
- Ischemia" implies a tissue damage derived from perfusion insufficiency, not just an inadequate blood supply. (springer.com)
- Ischemia is inadequate blood flow. (marketwatch.com)
- Even brief interruptions can cause brain ischemia, and potentially result in a situation called an ischemic cascade , where brain cells with inadequate blood supply start dying and releasing toxins that damage neighboring cells, causing them to rupture and release toxins of their own, creating a ripple effect across the brain. (wisegeek.com)
- Ischemia comprises not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. (wikipedia.org)
- Reduced blood flow to the heart associated with coronary ischemia can result in inadequate oxygen supply to the heart muscle. (wikipedia.org)
- Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
Oxygen12
- Hepatic ischemia is a condition in which the liver does not get enough blood or oxygen. (medlineplus.gov)
- During the initial ischemia phase, as well as during reperfusion, metabolic therapy can be very useful as, for example, glucose-insulin-potassium solutions (G-I-K). These could act as scavengers of the free radicals derived from oxygen and avoid or reduce the myocardial damage due to reperfused myocytes. (nih.gov)
- Brain ischemia is an interruption of the supply of blood to the brain, disrupting the flow of oxygen and nutrients needed to keep brain cells functioning. (wisegeek.com)
- Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). (wikipedia.org)
- The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
- When oxygen supply to the heart is unable to keep up with oxygen demand from the muscle, the result is the characteristic symptoms of coronary ischemia, the most common of which is chest pain. (wikipedia.org)
- Myocardial ischemia means your heart muscle is not getting enough blood (which contains oxygen and nutrients) to work as it should. (clevelandclinic.org)
- Ischemia is most likely to happen when your heart needs more oxygen and nutrients than it is getting. (clevelandclinic.org)
- The storage of organs in preservation solutions is followed by the ischemia of the organ, resulting in a shortage of oxygen and nutrients, which damage the tissues. (mdpi.com)
- Hepatic ischemia is a condition in which the liver does not get enough blood or oxygen, causing injury to liver cells. (floridahealthfinder.gov)
- Myocardial ischemia can be defined as a decreased supply of blood to the heart, and more precisely as an imbalance between the myocardial oxygen supply and demand. (google.es)
- Rather than in hypoxia , a more general term denoting a shortage of oxygen (usually a result of lack of oxygen in the air being breathed), ischemia is an absolute or relative shortage of the blood supply to an organ. (wikidoc.org)
Renal3
- Here, we show that acute exposure to bright blue spectrum light reduces organ injury by comparison with bright red spectrum or ambient white fluorescent light in two murine models of sterile insult: warm liver ischemia/reperfusion (I/R) and unilateral renal I/R. Exposure to bright blue light before I/R reduced hepatocellular injury and necrosis and reduced acute kidney injury and necrosis. (pnas.org)
- The kidneys are also quickly damaged by loss of blood flow (renal ischemia). (wikipedia.org)
- Is the Subject Area "Renal ischemia" applicable to this article? (plos.org)
Blood vessels4
- Most commonly, brain ischemia involves not the carotid artery , but one of the smaller blood vessels in the brain. (wisegeek.com)
- Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue. (wikipedia.org)
- Ischemia is a condition in which the blood vessels become blocked, and blood flow is stopped or reduced. (emedicinehealth.com)
- In medicine , ischemia ( Greek ισχαιμία , isch- is restriction , hema or haema is blood ) is a restriction in blood supply , generally due to factors in the blood vessels , with resultant damage or dysfunction of tissue. (wikidoc.org)
Cause brain ischemia3
- A number of things can cause brain ischemia, including strokes, trauma to the brain, and blood vessel abnormalities. (wisegeek.com)
- citation needed] A heart attack can also cause brain ischemia due to the correlation that exists between heart attack and low blood pressure. (wikipedia.org)
- citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
Brain ischemia include2
- Common symptoms of brain ischemia include weakness in the body, coordination problems, blindness, unconsciousness and speech impairments. (reference.com)
- Treatments for brain ischemia include alteplase to minimize the effects of ischemic strokes and anticonvulsants for the prevention of seizures, states the Columbia University Medical Center. (reference.com)
Transient brain ischemia2
- Hyperphosphorylation of the microtu-bule-associated protein tau induced by transient brain ischemia, shows a study. (medindia.net)
- We conclude that proteins are severely aggregated in hippocampal neurons vulnerable to transient brain ischemia. (jneurosci.org)
Causes Myocardial Ischemia1
- What Causes Myocardial Ischemia? (webmd.com)
Patients17
- Acute limb ischaemia can occur in patients through all age groups. (wikipedia.org)
- Patients that smoke and have diabetes mellitus are at a higher risk of developing acute limb ischaemia. (wikipedia.org)
- Injuries were associated with advanced (grade IIb) ischemia that affected the entire hand in four patients and first three digits in the other four patients. (nih.gov)
- The electrocardiogram (ECG) is an important test used in the clinical evaluation of patients with suspected or known myocardial ischemia or myocardial infarction (MI). (uptodate.com)
- It is likely that in previous trials dealing with patients with non-acute coronary artery disease, a sizable proportion of patients without ischemia has been included," perhaps diluting the effect of reversing ischemia with PCI, he noted. (medpagetoday.com)
- The 55% reduction in 7-year mortality when asymptomatic men with an abnormal ST/HR index were exposed to a rigorous risk factor reduction program 5 suggests that asymptomatic patients with both exercise-induced ischemia and increased carotid intimal-medial thickening may derive even greater prognostic benefit from aggressive risk factor modification. (ahajournals.org)
- Despite modern therapy, up to 8 million Americans with peripheral arterial disease are devastated by immobility, intractable ischemia, ulceration, impaired wound healing, or amputation, 1 and the lack of additional treatment options leaves many patients with little hope for relief. (ahajournals.org)
- The second protocol aims to prove that exercise Tcpo2 is efficient to estimate the benefit of proximal revascularisation on proximal and distal ischemia in patients suffering stage two lower extremity arterial disease. (clinicaltrials.gov)
- The last protocol is a transversal study of patients with aorto-bi-femoral bypasses aiming to analyse the presence of proximal and distal symptoms and ischemia. (clinicaltrials.gov)
- The hypothesis for protocols 3 and 4 relates on the hypothesis that a significant number of patients benefiting aorto-bi-femoral bypass suffer isolated proximal pain/ischemia after surgery. (clinicaltrials.gov)
- This is a multicenter randomized controlled trial with a target randomization of ~1000 patients with advanced CKD and at least moderate ischemia on stress testing. (clinicaltrials.gov)
- BOLD imaging may offer a way to see ischemia in these patients, he said. (diagnosticimaging.com)
- Waiting For ISCHEMIA: Why Won't Cardiologists Enroll Patients? (cardiobrief.org)
- OBJECTIVE -To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines. (diabetesjournals.org)
- The prevalence of ischemia in 522 patients randomized to stress testing was assessed by adenosine technetium-99m sestamibi single-photon emission-computed tomography myocardial perfusion imaging. (diabetesjournals.org)
- Myocardial ischemia in patients with diabetes is often asymptomatic and frequently in an advanced stage when it becomes clinically manifest ( 2 , 3 ). (diabetesjournals.org)
- Biphasic CT has become the gold standard in evaluating patients with suspected mesenteric ischemia. (appliedradiology.com)
Arterial9
- 1 The others are the result of arterial thrombosis (usually atherosclerotic in origin), venous thrombosis (typically from clotting disorders) and nonocclusive ischemia. (cmaj.ca)
- Hand ischemia is a rare but potentially devastating complication of radial artery cannulation for arterial monitoring. (nih.gov)
- Paralysis is a very late sign of acute arterial ischemia and signals the death of nerves supplying the extremity. (wikipedia.org)
- Venous problems like venous outflow obstruction and low-flow states can cause acute arterial ischemia. (wikipedia.org)
- An aneurysm is one of the most frequent causes of acute arterial ischemia. (wikipedia.org)
- Oxygenated blood or other medium is then perfused through the conduit in a controlled manner, preferably at a controlled pressure below the arterial pressure, to maintain oxygenation and relieve ischemia in tissue distal to the occlusion. (google.es)
- Ultrasound enhanced thrombolysis in acute arterial ischemia. (biomedsearch.com)
- The etiology of acute mesenteric ischemia can be divided into four categories: arterial embolization, arterial thrombosis, mesenteric venous thrombosis, and non-occlusive, low-flow state. (appliedradiology.com)
- Non-occlusive mesenteric ischemia does not demonstrate arterial filling defects or venous outflow occlusion and, therefore, has no typical imaging findings. (appliedradiology.com)
Myocardial Ischaemia1
- The report concludes that the Apple watch may be used to reliably detect myocardial ischaemia. (macrumors.com)
Diseases2
- Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
- Ischemia is a feature of heart diseases , transient ischemic attacks , cerebrovascular accidents , ruptured arteriovenous malformations , and peripheral artery occlusive disease . (wikidoc.org)
Left ventricular2
- Stepwise logistic regression analyses that included standard cardiac risk factors revealed that only carotid cross-sectional area index, systolic blood pressure, and/or left ventricular mass index predicted the presence of exercise-induced myocardial ischemia. (ahajournals.org)
- Longitudinal left ventricular contraction in pigs that received levosimendan before ischemia (0.75 ± 0.12 mm) was significantly higher than those received levosimendan during ischemia (0.53 ± 0.11 mm, p = 0.003) or Control pigs (0.54 ± 0.11 mm, p = 0.01). (frontiersin.org)
Treat chronic mesenteric2
- surgical treatment is usually required to effectively treat chronic mesenteric ischemia as well. (everything2.com)
- Surgery can treat chronic mesenteric artery ischemia, if needed. (healthline.com)
Prognosis1
- The prognosis of acute mesenteric ischemia of any type is grave. (go.jp)
Clinical4
- There are 7 teaching cases in this section on ischaemia imaging using Myocardial Contrast Echocardiography: One normal and one abnormal example to begin, then there are five real clinical patient studies with accompanying explanation(s). (escardio.org)
- Small phase I-II randomized and non-randomized clinical trials have shown promising results concerning the potential applications of ultrasound-enhanced thrombolysis in the setting of acute cerebral ischemia. (biomedsearch.com)
- The main goal of this article is to update etiology, epidemiology, diagnosis, treatment and outcome of the various causes of mesenteric ischemia in order to elucidate its labyrinthine clinical riddle, by reviewing the current English medical literature. (go.jp)
- Even if diagnostic modalities have improved since the first successful attempts to confront effectively this clinical entity, mesenteric ischemia still remains a lethal diagnostic enigma for the medical community. (go.jp)
Intestines4
- Tissue death from lack of blood flow (infarction) in the intestines is the most serious complication of mesenteric artery ischemia. (medlineplus.gov)
- Mesenteric artery ischemia is a condition that restricts blood flow to your intestines. (healthline.com)
- Usually, in the case of an acute ischemia attack, surgery removes blot clots, scar tissue, and parts of the intestines that have already died. (healthline.com)
- Mesenteric ischemia is decreased blood flow to the intestines. (emedicinehealth.com)
Coronary artery3
- Coronary artery disease (CAD) is the most common cause of coronary ischemia. (wikipedia.org)
- Coronary ischemia and coronary artery disease are contributors to the development of heart failure over time. (wikipedia.org)
- Coronary ischemia resulting from coronary artery disease also increases the risk of developing heart failure. (wikipedia.org)