Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
Unstable isotopes of zinc that decay or disintegrate emitting radiation. Zn atoms with atomic weights 60-63, 65, 69, 71, and 72 are radioactive zinc isotopes.
Method for assessing flow through a system by injection of a known quantity of radionuclide into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.
Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Unstable isotopes of krypton that decay or disintegrate emitting radiation. Kr atoms with atomic weights 74-77, 79, 81, 85, and 87-94 are radioactive krypton isotopes.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
Unstable isotopes of sodium that decay or disintegrate emitting radiation. Na atoms with atomic weights 20-22 and 24-26 are radioactive sodium isotopes.
The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Unstable isotopes of barium that decay or disintegrate emitting radiation. Ba atoms with atomic weights 126-129, 131, 133, and 139-143 are radioactive barium isotopes.
Stable iron atoms that have the same atomic number as the element iron, but differ in atomic weight. Fe-54, 57, and 58 are stable iron isotopes.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.
Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.
Organic and inorganic compounds that contain iron as an integral part of the molecule.
Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.
High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.
Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.
Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.
Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.
Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)
Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.
Inorganic or organic compounds containing trivalent iron.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.
Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.
Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.
Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.
Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.
Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.
Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.
Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Inorganic or organic compounds that contain divalent iron.
Pollutants, present in soil, which exhibit radioactivity.
Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)
Detection and counting of scintillations produced in a fluorescent material by ionizing radiation.
Unstable isotopes of bromine that decay or disintegrate emitting radiation. Br atoms with atomic weights 74-78, 80, and 82-90 are radioactive bromine isotopes.
Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.
Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.
Liquid, solid, or gaseous waste resulting from mining of radioactive ore, production of reactor fuel materials, reactor operation, processing of irradiated reactor fuels, and related operations, and from use of radioactive materials in research, industry, and medicine. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.
Uptake of substances through the lining of the INTESTINES.
Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.
Techniques used to determine the age of materials, based on the content and half-lives of the RADIOACTIVE ISOTOPES they contain.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.
Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.
Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.
Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.
Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.
A series of steps taken in order to conduct research.
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.
Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.
Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)
Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)
A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.

The effect of chelating agents on iron mobilization in Chang cell cultures. (1/266)

The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3-dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells. They are effective to an approximately equal degree. The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound. How far these phenomena relate to therapeutic potentially remains to be seen.  (+info)

Chemical and immunochemical measurement of total iron-binding capacity compared. (2/266)

Radiometric, colorimetric, and two immunochemical methods for measuring total iron-binding capacity are compared. We evaluated the procedures on the basis of precision, applicability to a pediatric population, and accuracy as assessed by analytical recovery of purified transferrin. The immunoephelometric assay for transferrin provides significant advantages over the other methods examined.  (+info)

Quantitation of Friend spleen focus-forming virus by a nine-day 59Fe assay. (3/266)

A previously described 3-day 59Fe assay for quantitation of Friend spleen focus-forming virus has been modified to produce a 200-fold more sensitive 9-day 59Fe assay. A characterization of this assay is reported here. Male BALB/c mice received intravenous injections of appropriately diluted Friend polycythemia virus (FVP); control mice received virus diluent. All mice were allowed food and water ad libitum for 6 days, and on day 6 after virus injection were fasted by removal of food but not water. On day 3 of the fast (the 9th day after virus injection) each mouse received an intraperitoneal injection of 1 muCi of 59Fe. Six hours later the mice were sacrificed and the splenic radioactivity was determined. The percent splenic incorporation of 59Fe was directly related to the logarithm of spleen focus-forming units (SFFU) of FVP injected in a range of approximately 25 to 1,000 SFFU. Using a standard FVP preparation in a dose range of 25 to 1,000 SFFU, it was possible to determine the SFFU titers of unknown samples by extrapolation of the percent splenic 59Fe incorporation to the logarithm of SFFU. SFFU titers obtained by the 9-day 59Fe assay were similar to those obtained by the enumerative-response assay. Advantages of the 9-day 59Fe assay over the enumerative-response assay include a 50-fold greater virus dose range, an easier and a more objective counting procedure, and a reduced coefficient of variation.  (+info)

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. (4/266)

HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E., Quintana, L., Starnes, S. M., Schatzman, R. C., Brunke, K. J., Drayna, D. T., Risch, N. J., Bacon, B. R., and Wolff, R. R. (1996) Nat. Genet. 13, 399-408). At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N., Irrinki, A., Feder, J. N., and Enns, C. A. (1998) J. Biol. Chem. 273, 22068-22074; Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J. A., Watson, N. , Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc. Natl. Acad. Sci. U S A 95, 1472-1477). HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998). Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling. Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments. HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered. These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake. These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE.  (+info)

Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption. (5/266)

Duodenal enterocytes adjust intestinal iron absorption to the body's state of iron repletion. Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips. Tissue uptake of parenterally applied 59Fe along the duodenal crypt-villus axis was compared to local IRP-1 and IRP-2 activity and to duodenal 59Fe transport capacity 12 h, 48 h, and 72 h after intravenous iron administration to iron-deficient rats. IRP-1 and IRP-2 activity was significantly increased in iron-deficiency. 59Fe administrated from the blood side was almost exclusively taken up by crypt enterocytes. Accordingly, the activity of IRP-1 decreased at this site 12 h after parenteral iron administration, but remained high at the villus tips. After 48 h the bulk of 59Fe containing enterocytes had migrated to the villus tips. Correspondingly, IRP-1 activity was decreased at duodenal villus tips after 48 h. IRP-2 activity also tended to decrease, though the change was statistically not significant. IRP-2 activity remained significantly higher at duodenal villus tips than in crypts, even after 72 h. Intestinal iron absorption capacity decreased with the same delay as IRP-1 activity after intravenous iron administration. In the ileum 59Fe uptake from the blood and IRP activity showed no significant difference between crypt and villus region. Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte. Our results are compatible with a role of IRPs in gearing the expression of intestinal iron transporters in the duodenal brushborder to the body's state of iron repletion.  (+info)

Transferrin stimulates iron absorption, exocytosis, and secretion in cultured intestinal cells. (6/266)

The cellular mechanism by which basolateral transferrin (Tf) produces an increase in apical-to-basolateral Fe flux in Caco-2 cells was analyzed. After a pulse of 59Fe from the apical medium, three types of basolateral 59Fe efflux were found: a 59Fe efflux that was independent of the presence of Tf in the basolateral medium, a 59Fe efflux in which 59Fe left the cell bound to Tf, and a Tf-dependent 59Fe efflux in which 59Fe came off the cell not bound to Tf. Furthermore, addition of Tf to the basolateral medium doubled the exocytosis rate of Tf and increased the secretion of apolipoprotein A, a basolateral secretion marker. Both apotransferrin and Fe-containing Tf produced similar increases in 59Fe efflux, Tf exocytosis, and apolipoprotein A secretion. The Ca2+ channel inhibitor SKF-96365 inhibited both the Tf-mediated increase in transepithelial Fe transport and the secretion of apolipoprotein A. Thus the activation of transepithelial Fe transport by Tf seems to be mediated by Ca2+ entry into the cells.  (+info)

3'-Azido-3'-deoxythymidine reduces the rate of transferrin receptor endocytosis in K562 cells. (7/266)

K562 cells, exposed for at least 24 h to 5 microM 3'-azido-3'-deoxythymidine (AZT), gave rise to an overall increase in the number of cell surface transferrin binding receptors (18-20%). This effect was ascertained either with binding experiments by using 125I-transferrin and with immunoprecipitation by using a specific monoclonal antibody against the transferrin receptor. At higher AZT concentrations (20 and 40 microM), a further increase was found, that is, up to 23% by binding experiments and up to 110% by immunoprecipitation. However, Scatchard analysis of the binding data indicated that although the number of cell surface transferrin receptors increased, the affinity of transferrin for its receptor did not change (Ka=4.0x108 M). Surprisingly, immunoprecipitation of total receptor molecules showed that the synthesis of receptor was not enhanced by the drug treatment. The effect of AZT on transferrin internalization and receptor recycling was also investigated. In this case, data indicated that the increase in the number of receptors at the cell surface was probably due to a slowing down of endocytosis rate rather than to an increased recycling rate of the receptor to cell surface. In fact, the time during which half the saturated amount of transferrin had been endocytosed (t1/2) was 2.15 min for control cells and 3.41, 3.04, and 3.74 min for 5, 20, and 40 microM AZT-treated cells, respectively. Conversely, recycling experiments did not show any significant differences between control and treated cells. A likely mechanism through which AZT could interfere with the transferrin receptor trafficking, together with the relevance of our findings, is extensively discussed.  (+info)

Increased expression of transferrin receptor on membrane of erythroblasts in strenuously exercised rats. (8/266)

This study investigated the effects of strenuous exercise on transferrin (Tf)-receptor (TfR) expression and Tf-bound iron (Tf-Fe) uptake in erythroblasts of rat bone marrow. Female Sprague-Dawley rats were randomly assigned to either an exercise or sedentary group. Animals in the exercise group swam 2 h/day for 3 mo in a glass swimming basin. Both groups received the same amount of handling. At the end of 3 mo, the bone marrow erythroblasts were freshly isolated for Tf-binding assay and determination of Tf-Fe uptake in vitro. Tissue nonheme iron and hematological iron indexes were measured. The number of Tf-binding sites found in erythroblasts was approximately 674,500 +/- 132,766 and 1,270,011 +/- 235,321 molecules/cell in control and exercised rats, respectively (P < 0. 05). Total Fe and Tf uptake by the cells was also significantly increased in the exercised rats after 30 min of incubation. Rates of cellular Fe accumulation were 5.68 and 2.58 fmol. 10(6) cells(-1). min(-1) in the exercised and control rats, respectively (P < 0.05). Tf recycling time and TfR affinity were not different in exercised and control rats. Increased cellular Fe was mainly located in the stromal fraction, suggesting that most of accumulated Fe was transported to the mitochondria for heme synthesis. The findings demonstrated that the increased cellular Fe uptake in exercised rats was a consequence of the increased TfR expression rather than the changes in TfR affinity and Tf recycling time. The increase in TfR expression and cellular Fe accumulation, as well as the decreased serum Fe concentration and nonheme Fe in the liver and the spleen induced by exercise, probably represented the early signs of Fe deficiency.  (+info)

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Thornes Iron Bisgylcinate is NSF Certified for Sport®. It is essential for the formation of red blood cells.* The U.S. Centers for Disease Control has determined that the prevalence of iron deficiency is greatest among toddlers (7% of those ages 1-2 years) and menstruating adolescent and adult females (9-16 % of individuals ages 12-49, whether they are athletes or not. Conventional iron supplementation, including forms such as ferrous sulfate, can cause gastrointestinal side effects - including nausea, vomiting, constipation, diarrhea, and dark-colored stools - because these conventional forms of iron are poorly absorbed. Thornes Iron Bisglycinate provides 25 mg of elemental iron per capsule that has been reacted with glycine for optimal absorption in the gastrointestinal tract, thus helping to decrease the typical gastrointestinal side effects ...
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INDICATIONS Vitamin A (as Vitamin a Palmitate) ............ 10,000.00 IU Vitamin C (as Sodium Ascorbate) .............. 1,500.00 mg Vitamin D3 (as Cholecalciferol) ............... 2,000.00 IU Magnesium (as TRAACS Magnesium Bisglycinate Chelate) ..... 125.00 mg Zinc (as TRAACS Zinc Bisglycinate Chelate) .......... 30.
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The oral application of a newly developed ferrous bisglycinate paste for suckling piglets at a dose of 180 mg/kg body weight led to increased death rates in 10% (n = 10) of Swiss test pig breeding farms (n = 100). Necropsy examination of suckling piglets (n = 12), selected randomly from the test farms with increased death rates, demonstrated severe gastric mucosal ulceration and necrosis. Due to the presence of crystalline iron surface coating within the gastric lesions, the iron was considered as the toxic principle and cause of death. To demonstrate the direct toxicity of ferrous bisglycinate, the paste was administered experimentally to a litter of suckling piglets (n=11). Different time points (24, 48 and 72 h post partum) and doses (180 mg/kg and 360 mg/kg) were investigated. The manufacturers recommended dose of 180 mg/kg corresponded to approximately 36 mg Fe/kg and to 6.4 % of the acute lethal dose(50) of oral iron in rats. In all piglets the lesions were reproduced and most severe at ...
Kirkmans Buffered Magnesium Bisglycinate is a hypoallergenic formulation for individuals with special requirements and sensitivities. Magnesium glycinate is a form of magnesium that is easier to digest and absorb than some other forms of magnesium. This product is also part of the Bio-Max Series‚ which uses forms of nutrients that have clinically proven to be among the best absorbed and most highly bioavailable. These capsules are buffered‚ which means that they are resistant to pH changes‚ making them less reactive and less likely to irritate the digestive tract-while also being easier to absorb. Kirkman uses magnesium glycinate exclusively sourced from Albion Labs‚ Inc. of Clearfield‚ Utah‚ a leader in the manufacture of mineral chelates. The use and effectiveness of magnesium supplementation is well-documented. Magnesium is an essential mineral that is involved in many bodily functions‚ while supporting strong bones and teeth. It is an essential element of cellular metabolism ...
Thornes Magnesium Bisgylcinate is NSF Certified for Sport®. Magnesium is essential for the health of the heart and blood vessels, brain, bones, skeletal muscles, lungs, and pancreas.* As a cofactor for more than 600 enzymes, magnesium supports numerous mechanisms of action; for example, it relieves bronchial spasms, relaxes smooth and skeletal muscle, enhances insulin sensitivity, and is a cofactor in numerous enzymatic reactions necessary for energy production.* Other magnesium mechanisms of action include modulating intracellular electrical activity and improving endothelial-dependent vasodilation, which support heart and lung health.* Thornes Magnesium Bisglycinate is formulated for optimal absorbability.* Its molecular structure also reduces the laxative effect typically seen in magnesium supplements.* Lightly sweetened with Monk Fruit and a hint of citrus. A low level of magnesium is associated with an increased level of C-reactive protein ...
Ferrasorb benefits those with a greater need for iron and those who have difficulty absorbing iron.* It contains active forms of vitamin B6, vitamin B12, folate and well-absorbed iron bisglycinate with vitamin C to enhance iron absorption.* Contains 36 mg of elemental iron per capsule Provides the active forms of folat
Magnesium Bis-Glycinate 200 delivers a significant 200mg dose of elemental magnesium in every capsule. Magnesium bisglycinate is the preferred form of magnesium due to its superior absorption and gentleness on the bowels. Each bottle contains a 240 day supply of 100% pure magnesium bisglycinate, in easy to swallow vegetable capsules. Magnesium has been shown by research to be essential to maintaining the health of bones and teeth as well as the functioning of muscles, including the heart muscle.. ...
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Reduced lglutathione (150 mg). Detoxification support†. 100 vegetarian capsules. magnesium (as traacs® magnesium bisglycinate chelate, magnesium oxide‡). Reduced lglutathione.
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Objective: To compare the effects of oral ferrous bisglycinate 25 mg iron/day vs. ferrous sulfate 50 mg iron/day in the prevention of iron deficiency (ID) and iron deficiency anemia (IDA) in pregnant women. Design: Randomized, double-blind, intention-to-treat study. Setting: Antenatal care clinic. Sample: 80 healthy ethnic Danish pregnant women.. Methods: Women were allocated to ferrous bisglycinate 25 mg elemental iron (Aminojern®) (n=40) or ferrous sulfate 50 mg elemental iron (n=40) from 15 to 19 weeks of gestation to delivery. Hematological status (hemoglobin, red blood cell indices) and iron status (plasma iron, plasma transferrin, plasma transferrin saturation, plasma ferritin) were measured at 15-19 weeks (baseline), 27-28 weeks and 36-37 weeks of gestation. Main outcome measures: Occurrence of ID (ferritin ,15 μg/L) and IDA (ferritin ,12 μg/L and hemoglobin ,110 g/L).. Results: At inclusion, there were no significant differences between the bisglycinate and sulfate group concerning ...
Arguably the most serious problem with most current nutrient risk assessment methodologies is that they are based upon the assessment of entire nutrient groups (e.g. vitamin D, vitamin E, calcium, zinc or iron), as opposed to individual nutrient forms (egg vitamin D3, gamma-tocopherol, calcium hydroxyapatite, zinc sulphate or iron bisglycinate).. Why is this important? Because, in short, the supposed risks from consuming a particular vitamin or a mineral are highly dependent upon the chemical form in which it is presented.. For example, ferrous sulphate, commonly prescribed by medical doctors to treat anaemia, is generally recognized as the most toxic form of iron, and can potentially cause a number of unpleasant side effects, including gastro-intestinal discomfort and nausea. However, iron bisglycinate, the form widely recommended by clinical nutritionists and nutritional therapists is a far gentler form of iron, and does not share the unpleasant the side effects of its relatively more toxic ...
The most favored speculation is that on binding to its receptor, Fe-citrate is dissociated and Fe and citrate are taken up independently by cells [forty,41], with the concomitant reduction of ferric iron in the approach. Our outcomes expose a remarkably very similar sample between Fe and citrate uptake, while a craze for a better rate of citrate uptake about Fe was noticed, supporting the speculation that various mechanisms regulate the uptake of the two components. The current benefits also display that the variances in Fe uptake in each and every experimental problem and the high correlation involving Fe3Cit3 and Fe uptake are not thanks to a preferential uptake of membrane-certain Fe in unique ailments but rather may possibly reflect a higher specificity of a putative receptor for the oligomeric Fe-citrate species. SolithromycinWe anticipate that this locating could be instrumental in the look for for the elusive Fe-citrate transporter because it represents the identification of the ligand to ...
|p|Iron SAP™ supports red blood cell formation, health hemoglobin and plasma ferritin levels, energy, stamina, immunity, and cognitive health.* Iron SAP™ contains the bisglycinate form for maximum absorption and efficacy, and enhanced GI toler
CLINICAL STRENGTH Chelate Mag 2 provides Magnesium, an essential mineral, in the form of an easy-to-absorb Patented Amion Acid Chelate compound of magnesium bisglycinate. Magnesium helps keep blood pressure stable, promotes heart health, regulates nerve and muscle function, and builds bone, DNA, and protein. A lack of magnesium may also contribute to headaches and migraines and sleepless nights.
|p|Dual-Mag Complex™ offers two unique forms of magnesium, buffered bisglycinate and lysinate glycinate chelates, that are broadspectrum in activity, well-tolerated, and highly bioavailable. This provides an efficacious, synergistic blend with numer
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13:19 Eliasvan: tobijk: because when the card is powered off I verified with nvagetbios that my previous write succeeded, but as soon as I modprobe nouveau, and then download the vbios via cat /sys/kernel/debug/dri/0/vbios.rom , vbios.rom to see whether the write is persistent, the write seems to be undone (overwritten by the default value ...
trackbot, comment ACTION-25 n the U.S. the EFOIA Amendments require agencies to make available any records that are requested by anyone and likely to be of interest to three or more citizens. It also requires agencies to take reasonable steps to make information available in whatever form it is requested, e.g., XML. (by Owen ...
Semantic Scholar extracted view of The uptake in vitro of radioactive iron by avian erythrocytes. by Wallace N. Jensen et al.
Looking for online definition of iron-59 in the Medical Dictionary? iron-59 explanation free. What is iron-59? Meaning of iron-59 medical term. What does iron-59 mean?
A delicious lemon-lime flavoured magnesium powder containing vitamins, minerals and amino acids. It provides 320mg of elemental magnesium per serve made up from magnesium citrate and magnesium bisglycinate, two well-absorbed forms of magnesium. Buy Herbs of Gold Muscle Resuscitation Online & Save It contains vitami
Different aspects related to the sol-gel preparation and structural investigation of silico-phosphate glasses (SiO2-P2O5 system) doped with Fe ions are reported. During the preparation process, tetrae
[105 Pages Report] Check for Discount on Global Ferric Citrate Market Professional Survey Report 2016 report by QYResearch Group. This report mainly covers the following Segment regions including (the...
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Objective: To compare the effects of oral ferrous bisglycinate 25 mg iron/day vs. ferrous sulfate 50 mg iron/day in the prevention of iron deficiency (ID) and iron deficiency anemia (IDA) in pregnant women. Design: Randomized, double-blind, intention-to-treat study. Setting: Antenatal care clinic. Sample: 80 healthy ethnic Danish pregnant women.. Methods: Women were allocated to ferrous bisglycinate 25 mg elemental iron (Aminojern®) (n=40) or ferrous sulfate 50 mg elemental iron (n=40) from 15 to 19 weeks of gestation to delivery. Hematological status (hemoglobin, red blood cell indices) and iron status (plasma iron, plasma transferrin, plasma transferrin saturation, plasma ferritin) were measured at 15-19 weeks (baseline), 27-28 weeks and 36-37 weeks of gestation. Main outcome measures: Occurrence of ID (ferritin ,15 μg/L) and IDA (ferritin ,12 μg/L and hemoglobin ,110 g/L).. Results: At inclusion, there were no significant differences between the bisglycinate and sulfate group concerning ...
Micronized Nutrient Capsule: Vitamin A (from beta carotene), Thiamin (Vitamin B1 from organic food blend), Riboflavin (Vitamin B2 from organic food blend), Niacin (Vitamin B3 as niacinamide from organic food blend), Vitamin B6 (Pyridoxine from organic food blend), Folate (Vitamin B9 from organic food blend), Vitamin B12 (Methylcobalamin), Biotin, Pantothenic Acid (Vitamin B5 from organic food blend), Iron (Ferrous Bisglycinate chelate), Magnesium (Magnesium glycinate chelate), Zinc (Zinc Bisglycinate chelate), Selenium (Selenium glycinate chelate), Copper (Copper bisglycinate chelate), Manganese (Magnesium bisglycinate chelate), Chromium (Chromium nicotinate glycinate chelate), Molybdenum (Molybdenum glycinate chelate), Proprietary Master Formula Capsule Blend: Atlantic kelp, Inositol, PABA (Para amino benzoic acid), Boron citrate, Lycopene, Spirulina algae, Barley grass, Citrus bioflavanoids, Orange fruit powder, NingXia wolfberry (Lycium barbarum) powder, Olive (Olea europea) leaf extract, ...
1. Iron absorption from 10 mg Fe (as ferrous sulphate), labelled with 1.3 mg 58Fe, was measured in fasting, non-anaemic adult subjects by the faecal-balance technique. The measurement was performed twice, each subject being given, in random order, either 50 mg Fe or a placebo 18 h before the 58Fe-labelled FeSO4. 2. The 50 mg Fe load significantly reduced Fe absorption the following day (P less than 0.01), from a mean of 35.4 (SEM 4.6)% to 29.0 (SEM 5.1)%. This points to the importance of strict dietary control during Fe-absorption studies to eliminate bias in results. 3. In a separate study, the feasibility of using 58Fe-enrichment of erythrocytes, measured by neutron activation analysis (NAA), 10 d after a meal labelled with 0.69 mg 58Fe as an index of Fe absorption was examined. The levels of 58Fe in the blood were detectable by NAA. Regression analysis showed a significant relation between 58Fe-enrichment of blood and 58Fe absorption, calculated as the difference between intake and faecal ...
With the growing interest of cardiovascular computed tomography around the world, international membership in the Society of Cardiovascular Computed Tomography (SCCT) has been increasing annually. As the number of SCCT members in a particular country or region grow to a certain size, it becomes feasible for those members to be able to establish an International Regional Committee (IRC) of SCCT. The Board of Directors recognizes this and actively encourages the formation of International Regional Committees for the mutual benefit for the local members in those regions and SCCT. IRCs are committees set up to promote cardiovascular CT and the objectives of SCCT in a certain region.. Australia/New Zealand (ANZ) IRC. Brazil IRC. Canada IRC. China IRC. Europe IRC. India IRC. Israel IRC. Japan IRC. Korea IRC. Latin America IRC. Middle East IRC. Taiwan IRC. UK IRC. To learn more about the International Regional Committee Policy, which details the criteria for IRCs, click here.. If you are interested in ...
Background: Food fortification is one approach for addressing anemia, but information on program effectiveness is limited.Objective: We evaluated the impact of Costa Ricas fortification program on anemia in women aged 15-45 y and children aged 1-7 y.Design: Reduced iron, an ineffective fortificant, was replaced by ferrous fumarate in wheat flour in 2002, and ferrous bisglycinate was added to maiz ...
rat HFE protein: an MHC class I-like protein that must bind beta2-microglobulin for proper cell surface expression; GenBank AJ001517
Using a selection system that was enriched for mutants unable to grow on low-iron media, Askwith et al. reported the identification of a mutant, fet3, that was unable to grow on low-iron media (14). This mutant had a normal surface reductase activity but was unable to accumulate 59Fe. A gene that could complement both the low-iron growth defect and the inability to accumulate radioactive iron was identified by complementation of the mutant strain with a genomic library. Genetic studies.... ...
Iron is a mineral Most of the iron in the body is found in the hemoglobin of red blood cells and in the myoglobin of muscle cells Iron is needed for transporting Get Price ...
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Definition of iron-binding capacity in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is iron-binding capacity? Meaning of iron-binding capacity as a finance term. What does iron-binding capacity mean in finance?
TY - JOUR. T1 - Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. AU - Drake, S.F.. AU - Morgan, Evan. AU - Herbison, C.E.. AU - Delima, R.. AU - Graham, R.M.. AU - Chua, A.C.G.. AU - Leedman, Peter. AU - Fleming, R.E.. AU - Bacon, B.R.. AU - Olynyk, J.K.. AU - Trinder, Debbie. PY - 2007. Y1 - 2007. N2 - Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. Am J Physiol Gastrointest Liver Physiol 292: G323-G328, 2007. First published August 24, 2006; doi:10.1152/ajpgi.00278.2006.-Hereditary hemochromatosis type 3 is an iron (Fe)-overload disorder caused by mutations in transferrin receptor 2 (TfR2). TfR2 is expressed highly in the liver and regulates Fe metabolism. The aim of this study was to investigate duodenal Fe absorption and hepatic Fe uptake in a TfR2 (Y245X) mutant mouse model of hereditary hemochromatosis type 3. ...
The molecular mechanisms by which iron is physiologically transported trough the cellular membranes are still only partially understood. Several studies indicate that a reduction step of ferric iron to ferrous is necessary, both in the case of transferrin-mediated and transferrin-independent iron uptake. Recent studies from our laboratory described gamma-glutamyltransferase activity (GGT) as a factor capable to effect iron reduction in the cell microenvironment. GGT is located on the outer aspect of plasma membrane of most cell types, and is often expressed at high levels in malignant tumors and their metastases. The present study was aimed at verifying the possibility that GGT-mediated iron reduction may participate in the process of cellular iron uptake. Four distinct human tumor cell lines, exhibiting different levels of GGT activity, were studied. The uptake of transferrin-bound iron was investigated by using 55Fe-loaded transferrin, as well as by monitoring fluorimetrically the intracellular iron
The anemia of chronic disease traditionally is defined as a hypoproliferative anemia of no apparent cause that occurs in association with an inflammatory, infectious, or neoplastic disorder, and resolves when the underlying disorder is corrected. Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, decreased transferrin saturation, increased serum ferritin, increased reticuloendothelial iron stores, increased erythrocyte-free protoporphyrin, and reduced iron absorption, is a characteristic feature of the anemia of chronic disease and has been thought to be a major factor contributing to the syndrome. 1
1990: Graduate assistant / Prirodno-matemati ki fakultet (Belgrade, Serbia). 1996-2010: Assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia). 2010-2015: Scientific associate / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia). 2015: Scientific associate / Ministarstvo prosvete, nauke i tehnolo kog razvoja (Belgrade, Serbia). 2015: Scientific associate / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia). ...
Magnesium Glycinate is an easy-to-absorb, supplemental form of magnesium, a critical mineral element required as a cofactor in more than 300 enzymes. Magnesium (as Magnesium bisglycinate chelate, magnesium oxide) 100mg
When ferritin is reconstituted from Fe and apoferritin in vitro in the presence of Pi, the product obtained differs both from native ferritin and from ferritin reconstituted in the absence of Pi. When the latter is incubated with Pi the product resembles native ferritin with respect both to the pattern of Pi incorporated per molecule or per Fe atom and to the ease of release of this Pi relative to Fe release. It is concluded that much of the Pi of native ferritin is adsorbed on surfaces of ferritin iron-core crystallites. The results also suggest that Pi is not present at the intracellular site of Fe incorporation into ferritin, but is added after Fe. ...
Low iron is a problem for many - especially women during their childbearing years, and for children. Read how you can maximize your iron absorption to help fight low iron levels!
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If doubts have been expressed as to the fact of iron absorption, there has been still more controversy as to the mode in which it is effected, and this, indeed, may differ according to the preparation...
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Covers iron (Fe) test to check the amount and use of iron in the blood. Explains why test is done and how to prepare. Includes possible results and what they may mean. Looks at what may affect test results.
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Small druglike compound rescues defective iron transport Learn more: http://scim.ag/2q7hizI Read the research($): http://science.sciencemag.org/conten...
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Iron in its various forms, but more particularly in certain solutions, has a direct effect upon the tissues with which it comes in contact and before it enters the circulation. It is more or less str...
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In another study, 17 subjects received iron supplement shots containing radioisotopes of iron. Neither the children nor their ... Radioisotope Studies at the Fernald State School, Massachusetts". Retrieved 2017-06-24. SHARPE LM, PEACOCK WC, COOKE R, HARRIS ... MIT Professor of Nutrition Robert S. Harris led the experiment, which studied the absorption of calcium and iron. The boys were ... The 57 club members ate iron-enriched cereals and calcium-enriched milk for breakfast. In order to track absorption, several ...
... and thus is particularly suitable as an imaging radioisotope. Gadolinium(III), Iron(III), Manganese(II): For MRI imaging ... Iron: iron toxicity, iron poisoning, or iron overload is well known. Iron does test only very weakly positive for the Ames test ... Platinum, Titanium, Vanadium, Iron: cis DDP (cis-diaminedichoroplatinum), titanium, vanadium, and iron have been shown to react ... Examples of specific types of metal anemia include: Iron: common simple anemia (iron deficiency), results in the loss of ...
Brucer invented an "iron maiden" containing radioactive sand which was tested for the treatment of breast cancer. That year he ... Brucer told a conference that the use of radio-isotopes of iodine, gold and phosphorus was becoming increasingly commonplace. ... Iron maiden' tried for breast cancer (1955) - on Newspapers.com". Newspapers.com. Retrieved 2016-11-13. "Atom scientists fight ... They were given atomic "cocktails" to drink and injections of radio-isotopes, and became temporarily radioactive. While not ...
The ore is then added to a leach tank of sulfuric acid and ferrous iron (Fe2+) in a 1.6:1 ratio. The iron reacts with the ... Several radioisotopes have been isolated and described, ranging in atomic weight from 44 u (44Mn) to 69 u (69Mn). The most ... The male magnes attracted iron, and was the iron ore now known as lodestone or magnetite, and which probably gave us the term ... Manganese(III) reacts with iron(II) to induce a strong green color in glass by forming less-colored iron(III) and slightly pink ...
This iron potassium cyanide compound acts as an ion-exchanger. The cyanide is so tightly bonded to the iron that it is safe for ... Just because a radioisotope is released it does not mean it will enter a human and then cause harm. For instance, the migration ... This paper also reports details of the effect of potassium, ammonium and calcium ions on the uptake of the radioisotopes. In ... If the radioisotope is tightly bound to the minerals in the soil, then less radioactivity can be absorbed by crops and grass ...
The mixtures contained radioactive iron and the researchers were determining how fast the radioisotope crossed into the ... The bones were cremated and the ashes analyzed for radioisotopes. This project was kept secret primarily because it would be a ... which keeps the remains of people who died with radioisotopes in their body. Three patients at Billings Hospital at the ... 73 mentally disabled children were fed oatmeal containing radioactive calcium and other radioisotopes, in order to track "how ...
They have also been identified as potential ligands for radioisotope delivery, with selectivity towards hypoxic tissues, ... usually mediated through binding to copper or iron in cells. ...
Ruthenium and osmium have very similar chemistry due to the lanthanide contraction but iron shows some differences from them; ... using the synthetic osmium radioisotopes 172Os and 173Os as a reference. During the experiment, seven hassium atoms were ... The team bombarded a lead (208 82Pb ) target with accelerated iron (58 26Fe ) nuclei. GSI's experiment to create element 108 ... In preparation for the chemical characterization of hassium, research focused on ruthenium and osmium rather than iron because ...
Since newer radioisotopes involve nanoparticles such as 99mTC-labelled iron oxide nanoparticles, they could potentially be ... Unlike PET, the radioisotopes used in SPECT (such as technetium-99m) emit γ-rays directly, instead of from annihilation events ... As the radioisotopes decay, they emit positrons which annihilates with electrons found naturally in the body. This produces 2 γ ... Almost any biological compound can be traced by micro-PET, as long as it can be conjugated to a radioisotope, which makes it ...
No clear geochronological data exist for CIDs, as no radioisotope methods are applicable to directly date CID deposits. ... The source of iron for the CIDs is believed to be a Miocene aged iron-rich soils which developed upon a palaeosurface (since ... Channel iron deposits are formed by accumulation of massive deposits of what is generally referred to as "pisolite iron gravels ... Channel iron deposits (CID) are iron-rich fluvial sedimentary deposits of possible Miocene age occupying meandering ...
Iron may be the most common as it accounts for 90% of all refined metals. Platinum may be the most ubiquitous given it is said ... heavy metals are also employed as spallation targets for the production of neutrons or radioisotopes such as astatine (using ... Heat escaping from the inner solid core is believed to generate motion in the outer core, which is made of liquid iron alloys. ... In golf, tungsten, brass, or copper inserts in fairway clubs and irons lower the centre of gravity of the club making it easier ...
In contrast, iron forms a more porous oxide through which oxygen can migrate, causing continued rusting. Passivation can be ... 19 radioisotopes have been characterized, with the most stable being 50Cr with a half-life of (more than) 1.8×1017 years, and ... Chromium, unlike iron and nickel, does not suffer from hydrogen embrittlement. However, it does suffer from nitrogen ...
The inclusion of iron and chromium rich regions probably originate from a molten nozzle that did not have enough time to be ... An eventually present layer of more dense molten metal, containing fewer radioisotopes (Ru, Tc, Pd, etc., initially composed of ... The zirconium-rich phase was found around the pores and on the grain boundaries and contains some iron and chromium in the form ... and is initially composed primarily of zirconium dioxide and uranium dioxide, possibly with iron oxide and boron oxides), can ...
Unlike the lighter congener iron, ruthenium is paramagnetic at room temperature, as iron also is above its Curie point. The ... Of these radioisotopes, the most stable are 106Ru with a half-life of 373.59 days, 103Ru with a half-life of 39.26 days and ... Like iron but unlike osmium, ruthenium can form aqueous cations in its lower oxidation states of +2 and +3. Ruthenium is the ... Fifteen other radioisotopes have been characterized with atomic weights ranging from 89.93 u (90Ru) to 114.928 u (115Ru). Most ...
... iron radioisotopes MeSH D01.496.749.540 - krypton radioisotopes MeSH D01.496.749.560 - lead radioisotopes MeSH D01.496.749.590 ... iron radioisotopes MeSH D01.496.532.500 - mercury radioisotopes MeSH D01.496.586.520 - nitrogen radioisotopes MeSH D01.496. ... xenon radioisotopes MeSH D01.496.749.960 - yttrium radioisotopes MeSH D01.496.749.980 - zinc radioisotopes MeSH D01.496.807.800 ... xenon radioisotopes MeSH D01.496.943.800 - yttrium radioisotopes MeSH D01.496.966.800 - zinc radioisotopes MeSH D01.524.500.040 ...
However, nickel-56 then decays to cobalt-56 within a few weeks, then this radioisotope finally decays to iron-56 with a half ... followed by iron-58 and iron-56. This is the approximate basic reason why iron and nickel are very common metals in planetary ... Iron nuclei are the most stable nuclei (in particular iron-56), and the best sources of energy are therefore nuclei whose ... and past iron, the second increase outweighs the first. Iron-56 (56Fe) is the most efficiently bound nucleus meaning that it ...
... iron oxides and iron in an electric furnace. The vanadium ends up in pig iron produced from vanadium-bearing magnetite. ... Twenty-four artificial radioisotopes have been characterized, ranging in mass number from 40 to 65. The most stable of these ... If this titanomagnetite is used to produce iron, most of the vanadium goes to the slag, and is extracted from it. Vanadium is ... Vanadium is harder than most metals and steels (see Hardnesses of the elements (data page) and iron). It has good resistance to ...
The prices of iron ore rose sharply from around $10 per metric ton in 2003 to around $170 in April 2009 (transported to China ... TV screens and in radio isotopes. Demand for these metals appeared to be increasing as computers and mobile phones became more ... "Iron Ore - Monthly Price - Commodity Prices - Price Charts, Data, and News - IndexMundi". Retrieved 2 May 2015. "Hot-rolled ... The major metals such as iron, lead and tin are commonplace.[citation needed] Recycling of the aluminum, ferrous metals, copper ...
... iron, and protein amounts to aiding micronutrient deficiency in Third World countries like the Philippines. Dr. Rhodora R. ... a radioisotope laboratory, and screenhouses for testing the modified rice. On December 4, 2006, the Philippine Rice Research ...
Both are characteristic components of meteoric iron, though cobalt is much less abundant in iron meteorites than nickel. As ... Twenty-two radioisotopes have been characterized: the most stable, 60Co, has a half-life of 5.2714 years; 57Co has a half-life ... Except as recently delivered in meteoric iron, pure cobalt in native metal form is unknown on Earth. The element has a medium ... Cobalt-57 (Co-57 or 57Co) is a cobalt radioisotope most often used in medical tests, as a radiolabel for vitamin B12 uptake, ...
Iridium radioisotopes are used in some radioisotope thermoelectric generators. Iridium is found in meteorites with an abundance ... the high density and tendency of iridium to bond with iron caused most iridium to descend below the crust when the planet was ... Although the element is only mildly toxic, it is a hazardous material as a metal and its radioisotopes present a high health ... Caesium is mined mostly from pollucite, while the radioisotopes, especially caesium-137, a fission product, are extracted from ...
Online fuel processing can introduce risks of fuel processing accidents, which can trigger release of radio isotopes. In some ... Alloys based on nickel and iron are prone to embrittlement under high neutron flux. Corrosion risk. Molten salts require ... Structural metal such as chromium, nickel, and iron must be removed for corrosion control. A water content reduction ...
... includes the study of both natural and man-made radioisotopes. All radioisotopes are unstable isotopes of ... iron(III), cobalt(III), manganese(IV) and uranium(VI) as electron acceptors while acetate, glucose, hydrogen, lactate, pyruvate ... Radiochemistry also includes the study of the behaviour of radioisotopes in the environment; for instance, a forest or grass ... for example the action of cosmic rays on the air is responsible for the formation of radioisotopes (such as 14C and 32P), the ...
Iron and its alloys respond best to induction heating, due to their ferromagnetic nature. Eddy currents can, however, be ... Component of Stirling radioisotope generator is heated by induction during testing. Induction heating is the process of heating ... Metals melted include iron and steel, copper, aluminium, and precious metals. Because it is a clean and non-contact process it ... In induction cooking, an induction coil in the cook-top heats the iron base of cookware by magnetic induction. Copper-bottomed ...
Their name comes from their relatively low iron abundance, with respect to the H chondrites, which are about 20-25% iron by ... Many of the L chondrite meteors may have their origin in the Ordovician meteor event, radioisotope dated with uranium-lead at ... Characteristic is the fayalite content (Fa) in olivine of 21 to 25 mol%. About 4-10% iron-nickel is found as a free metal, ... as well as iron-nickel and troilite. Chromite, sodium-rich feldspar and calcium phosphates occur in minor amounts. Petrologic ...
Silicon-32 Phosphorus-32 Sulfur-35 Sulfur-38 Chlorine-34m Chlorine-36 Chlorine-38 Chlorine-39 Argon-39 Argon-42 Calcium-41 Iron ... A trace radioisotope is a radioisotope that occurs naturally in trace amounts (i.e. extremely small). Generally speaking, trace ... Trace radioisotopes are therefore present only because they are continually produced on Earth by natural processes. Natural ... radioisotopes have half-lives that are short in comparison with the age of the Earth, since primordial nuclides tend to occur ...
During a period in which little was known about iron-deficiency anemia, how often it occurred or the principles of iron ... made significant findings in his research at the University of Washington throughout his 60-year tenure using radioisotopes to ... Treatment of Iron Deficiency Anemia in the Adult (1957), The Diagnosing of Iron deficiency Anemia (1964), Pathophysiologic ... the uptake and release of iron in human transferrin, rat transferrin and gene expression, the iron binding sites of human ...
Anaerobic oxidation of iron by the protons of water at high temperature can be schematically represented by the set of ... is also sometimes considered as a light radioisotope of hydrogen, due to the mass difference between the antimuon and the ... Because iron is widely used structural material, its anaerobic corrosion is of technological significance: Fe + 2 H 2O → Fe(OH ... Iron, for instance, would oxidize, and thus decrease the amount of oxygen given off.) The theoretical maximum efficiency ( ...
... radioisotopes are used in some radioisotope thermoelectric generators. Iridium is found in meteorites in much higher ... A reinvestigation of irons with Ge concentrations between 25 and 80 ppm". Geochimica et Cosmochimica Acta. 37 (8): 1957-1983. ... The radioisotope iridium-192 is one of the two most important sources of energy for use in industrial γ-radiography for non- ... At least 37 radioisotopes have also been synthesized, ranging in mass number from 164 to 202. 192Ir, which falls between the ...
Magnetic beads are made of nanometric-sized iron oxide particles encapsulated or glued together with polymers. These magnetic ... radioisotopes (RIA) or fluorescent moieties (fluorescent immunoassays) to detect a specified analyte. MIA involves the specific ...
Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging ... Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging. Table 1. ...
It resembles iron or nickel.. How can it hurt me?. Because it decays by gamma radiation, external exposure to large sources of ...
BETA DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; ... 62 RADIOLOGY AND NUCLEAR MEDICINE; GALLIUM 67; BIOLOGICAL LOCALIZATION; HEPATOMAS; SCINTISCANNING; LIVER; BLOOD SERUM; IRON ... RADIOISOTOPE SCANNING; RADIOISOTOPES; TRANSITION ELEMENT COMPOUNDS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics ... and iron in blood probably affected /sup 67/Ga accumulation in liver cancer.}. journal = {Shindan To Chiryo; (Japan)}. volume ...
Tens of millions of nuclear medicine procedures are performed each year, and demand for radioisotopes is increasing rapidly ... the use of radioisotopes for diagnostics, radiation therapy, radiopharmaceuticals and other beneficial medical uses of nuclear ... Iron-59 (46 d):. Used in studies of iron metabolism in the spleen. ... The global radioisotope market was valued at $9.6 billion in 2016, with medical radioisotopes accounting for about 80% of this ...
... iron, cobalt, nickel, copper, molybdenum; The other transition metals and zinc; The metalloids: arsenic, antimony, selenium, ... tellurium and boron; The new metal contaminants; The radioactive metals; Radioisotopes; The catalytic metals; The electronic ...
The iron for the three complexes was in temperature-independent high spin state by 57Fe Mössbauer spectroscopy and magnetic ... In the local structure around the iron atom, the coordinated pyridine planes were shown to be a parallel type, which is in ... Radioisotopes 2017, in press. [Google Scholar]. *Biradha, K.; Fujita, N. 2D and 1D Coordination Polymers with the Ability for ... Figure 5 shows why: In order for the iron atom to become LS, the ligands must approach the iron. In this conformation, this ...
Pure iron, I mean. Not steel.. Q: Now, people talk about its radioactive properties. How does it compare with other radio- ... Not much different than a chunk of metallic iron, for example.. Q: What color is it?. A: Dark metallic color. Color, as I say, ... not much difference than a metallic iron. ...
metals or metalloids of environmental concern, denser than iron 200 Do radioisotopes bioconcentrate ...
Iron Radioisotopes / pharmacology*. Monocytes / metabolism*, radiation effects*. NF-kappa B / metabolism*, radiation effects*. ... 0/DNA-Binding Proteins; 0/I-kappa B Proteins; 0/Iron Radioisotopes; 0/NF-kappa B; 9007-49-2/DNA ...
Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging ...
... an enzyme regulating the proteins responsible for cellular iron (Fe) equilibrium. This study was performed to investigate ... Iron Radioisotopes / pharmacokinetics Actions. * Search in PubMed * Search in MeSH * Add to Search ... Iron Overload Following Manganese Exposure in Cultured Neuronal, but Not Neuroglial Cells W Zheng et al. Brain Res. 2001 ... Brain iron homeostasis. Moos T. Moos T. Dan Med Bull. 2002 Nov;49(4):279-301. Dan Med Bull. 2002. PMID: 12553165 Review. ...
I. Iron(III) phthalocyanine as a labeling reagent, Bull. Chem. Soc. Jpn. 56:2267 2271, 1983. ... The field of nuclear medicine utilizes radioisotopes, usually gamma-emitting isotopes, for diagnostic purposes. Radioactive ... I. Iron(III) phthalocyanine as a labeling reagent, Bull. Chem. Soc. Jpn. 56:2267-2271, 1983. ... I. Iron(III) Phthalocyanine as a labeling reagent, Chemical Abstracts 99:320, Abstract 172173u, 1983. ...
Radioisotopes of iron and chromium were also valuable in applications in hematology. Red blood cell survival, iron physiology, ... Other reactor-produced radioisotopes continue to play a major role in research, and recent advances in many fields (such as ... A comparison of Tables 3-1 and 3-4 makes it obvious that however ably Nordion is serving the needs of commercial radioisotope ... Two other reactor-produced radioisotopes, samarium-153 and rhenium-186, may also be of use in the treatment of bone cancer and ...
Radioisotope Scan Encyclopedia section of medindia gives general info about Nuclear Medicine ...
Radioisotope. Fe-55. Radionuclide. 55Fe. Shipping Condition. Ambient. Special Ordering Information. This is a radioactive ... Iron-55 Radionuclide Ferric chloride in 0.5M HCl Shipped ambient. Iron chloride in 0.5M Hydrochl>3Ci(111GBq)/g ... Iron-55 Radionuclide, 5mCi (185MBq), Ferric Chloride in 0.5M HCl Part Number : NEZ043005MC ...
In another study, 17 subjects received iron supplement shots containing radioisotopes of iron. Neither the children nor their ... Radioisotope Studies at the Fernald State School, Massachusetts". Retrieved 2017-06-24. SHARPE LM, PEACOCK WC, COOKE R, HARRIS ... MIT Professor of Nutrition Robert S. Harris led the experiment, which studied the absorption of calcium and iron. The boys were ... The 57 club members ate iron-enriched cereals and calcium-enriched milk for breakfast. In order to track absorption, several ...
Fermi and his associates succeeded in producing radioisotopes of sodium, iron, copper, gold, and numerous other elements. As a ... RADIOISOTOPE:. An isotope subject to the decay associated with radioactivity. A radioisotope is thus an unstable isotope. ... A radioisotope does not "rot"; it decays by turning into another isotope of the same element-or even into another element ... Yet radioisotopes in general have so many uses, in comparison to stable isotopes, that they are often referred to simply as " ...
Stable isotopes can be used as alternatives to radioisotopes or fluorescent DNA labels. After the labeled DNA has been banded ... Methods for synthesizing appropriate labels and for detecting isotopes of iron and tin directly on polyacrylamide gels are ... radioisotope, fluorescent, or chemiluminescent labels) target DNA to an array of DNA probes immobilized above the pixels. Such ...
I used the radioisotopes iron-55 and iron-59, manganese-52, and zinc-65 as tracers. At the end of my Ph.D. research I was ... This unit was charged with utilizing radioisotopes for research in plant nutrition; I imagine that I was one of a mere handful ... My major professor was Perry R. Stout, a pioneer in the then novel application of radioisotopes of physiologically important ... My research dealt with the absorption of the micronutrients iron, manganese, zinc, and copper by tomato plants. ...
... and thus is particularly suitable as an imaging radioisotope. Gadolinium(III), Iron(III), Manganese(II): For MRI imaging ... Iron: iron toxicity, iron poisoning, or iron overload is well known. Iron does test only very weakly positive for the Ames test ... Platinum, Titanium, Vanadium, Iron: cis DDP (cis-diaminedichoroplatinum), titanium, vanadium, and iron have been shown to react ... Examples of specific types of metal anemia include: Iron: common simple anemia (iron deficiency), results in the loss of ...
In addition, it has been shown that genetic background may impact iron metabolism. Our objective was to characterize, in mice ... Iron is reported to interact with other metals. ... In: Lewis SM (ed) Radioisotopes in haematology. Sauders, London ... iron parameters were modulated by genetic background with significantly higher values for plasma iron parameters and liver iron ... Iron is reported to interact with other metals. In addition, it has been shown that genetic background may impact iron ...
2: Anemia and Iron *2.1: Elements and the Structure of the Atom (5) ... 2.5: Radioisotopes (5). *2: Chemistry in Medicine: Nuclear Radiation in Medical Imaging ...
Ironing out technetium contamination. Millions of medical imaging procedures each year rely on radioactive technetium. One of ... its radioisotopes decays quickly and is useful as a tracer material in nuclear... ...
We do most of our x-ray fluorescence excitation with radioisotope. sources. The only requirement is that the source have photon ... for excitation are Iron-5b, Cadmium-109 and Samarium-145. Wi th these ...
nuclear reactors, and radioisotope generators. Most radioisotopes used for radiodiagnostics and radiotherapeutics are produced ... produced isotopes (e.g., iron-59, iodine-131, and technetium-99m) that have become invaluable nuclides for nuclear molecular ... In addition to cyclotron-produced radioisotopes, nuclear reactors produce medical radioisotopes by either separation of ... John H. Lawrence, a physician, used his brother Ernests radioisotopes in humans, treating a leukemia patient in 1937. John was ...
  • The Advisory Committee on Human Radiation Experiments, reporting to the United States Department of Energy in 1994, reported on these experiments: In 1946, one study exposed seventeen subjects to radioactive iron. (wikipedia.org)
  • Milk formulas and reference dose were labeled with radioisotopes 59 Fe or 55 Fe, and the absorption of iron measured by erythrocyte incorporation of radioactive Fe. (mdpi.com)
  • The radioisotopes decay according to their nature (there are several mechanisms), and often we see a radioactive product (called a daughter) created by the decay process. (answers.com)
  • A.K.A. Radioisotope) Some isotopes are naturally stable - they will not undergo radioactive decay. (umd.edu)
  • Spontaneous redox continuum reveals sequestered technetium clusters and retarded mineral transformation of iron, Communications Chemistry (2020). (phys.org)
  • My research dealt with the absorption of the micronutrients iron, manganese, zinc, and copper by tomato plants. (gf.org)
  • High-grade transvaal chalcopyrite was neutron-irradiated to produce radioisotopes copper- 64, iron-59, and sulfur-35. (cdc.gov)
  • Though generally composed of manganese (hence the name), they can also be made of iron, nickel, copper, and other metals. (icr.org)
  • Metals melted include iron and steel , copper , aluminium , and precious metals . (wikipedia.org)
  • 1984). High levels of dietary iron, zinc, copper and pectin reduce the utilization of ascorbic acid, either by direct oxidation of vitamin C or by reducing its absorption (Sauberlich, 1990). (dsm.com)
  • For more than 60 years, IRON-A-WAY has been manufacturing built-in ironing centers. (tcs2019.net)
  • Without accurately known decay half-lives, all radioisotope ages cannot be accurately determined or be considered absolute ages. (answersingenesis.org)
  • Dr. Snelling documents the methodology and history of determining present decay constants and half-lives of parent radioisotopes used for dating methods. (answersingenesis.org)
  • u "It will be shown that the observations of near-ground AGR [atmospheric gamma radiation] following lightning are consistent with the production and subsequent decay of a combination of atmospheric radioisotopes [and new chemical elements] with 10-100 minute half-lives produced via nuclear reactions on the more abundant elements in the atmosphere. (creationscience.com)
  • This concept of 'deep time' is firmly based on the uniformitarian view of nature, i.e., that decay rates for radioisotopes have always been as they appear today. (icr.org)
  • 9 It should be noted here that there are ways to accelerate radioisotope decay. (icr.org)
  • That is, the episodes of nuclear decay speedup (for which we found multiple lines of evidence) would collapse the radioisotope timescale from billions of years down to thousands of years, but the order of dates would remain the same. (creation.com)
  • Our previous studies show that manganese (Mn) exposure inhibits aconitase, an enzyme regulating the proteins responsible for cellular iron (Fe) equilibrium. (nih.gov)
  • Examples of specific types of metal anemia include: Iron: common simple anemia (iron deficiency), results in the loss of functional heme proteins (hemoglobin, myoglobin, etc.), which are responsible for oxygen transport or utilization of oxygen. (wikipedia.org)
  • However, the FepA and IroN proteins of S. typhimurium failed to efficiently function in E. coli . (asm.org)
  • Pathogenic and commensal bacteria alike obtain iron from human and animal hosts by competing for the metal with eucaryotic proteins, like transferrin, lactoferrin, and ferritin ( 11 , 25 , 49 , 54 ). (asm.org)
  • Siderophores ( 32 ) liberate iron from the sequestering proteins of eucaryotic hosts or solubilize it from precipitates of ferric oxyhydroxide, rendering the metal available for microbial consumption. (asm.org)
  • On the other hand, superparamagnetic iron oxide nanoparticles (SPIO or IONPs) typically provide a different contrast-enhancing mechanism. (sigmaaldrich.com)
  • They found success using superparamagnetic iron oxide nanoparticles (SPIONs). (nih.gov)
  • In addition, it has been shown that genetic background may impact iron metabolism. (springer.com)
  • Our data: (i) confirms the impact of the genetic background on iron parameters, (ii) shows that genetic background may also play a role in the metabolism of non-iron metals, (iii) identifies links between iron and other metals parameters which may have implications in the understanding and, potentially, the modulation of iron metabolism. (springer.com)
  • Andrews NC (1999) Disorders of iron metabolism. (springer.com)
  • Tracer techniques using isotopes of iron allow investigation of iron metabolism and erythropoietic function. (annals.org)
  • Iron metabolism. (thefreedictionary.com)
  • Most iron reaches the body in food, where it occurs naturally in the form of iron compounds. (thefreedictionary.com)
  • Compounds tagged with Fe-59 and Fe-55 are used to study the absorption of iron. (kentchemistry.com)
  • Among the compounds we tested, only ferric enantioenterobactin, the synthetic, left-handed isomer of natural enterobactin, and ferric TRENCAM, which substitutes a tertiary amine for the macrocyclic lactone ring of ferric enterobactin but maintains an unsubstituted catecholate iron complex, were recognized by FepA ( K d ≈ 20 nM). (asm.org)
  • Radioisotopes of iron and chromium were also valuable in applications in hematology. (nap.edu)
  • The serial sectioning method was applied to simultaneous evaluation of diffusion rates of chromium, manganese and iron in both spinels at 1073 K and 1173 K under the pressure of 105 Pa in SO2 containing 10 Pa O2. (scientific.net)
  • Moreover the dominant mechanism of manganese transport (the highest one) in studied samples is the volume diffusion while chromium and iron are transported mainly through the high diffusivity paths. (scientific.net)
  • Vitamin C enhances absorption of iron, and alkalis hamper absorption. (thefreedictionary.com)
  • The purpose of this study has been to investigate the absorption of iron in various kinds of liver disease and to determine the influence of some of the factors which might affect absorption. (bl.uk)
  • Especial attention has bean paid to the possible role of the pancreas in influencing the absorption of iron in these conditions. (bl.uk)
  • The absorption of iron was studied in a total of 39 patients with liver disease. (bl.uk)
  • The absorption of iron was studied using the radio-isotope balance technique introduced by Dubach, Callender and Moore (1948). (bl.uk)
  • The absorption of iron in these patients was comparable to that seen in normal control subjects, but iron overload usually reduces absorption. (bl.uk)
  • It resembles iron or nickel. (cdc.gov)
  • Why did the researchers not look for shorter-lived radioisotopes such as iron 60 ( 60 Fe), nickel 59 ( 59 Ni), manganese 53 ( 53 Mn), krypton 81 ( 81 Kr), calcium 41 ( 41 Ca), carbon 14 ( 14 C), or even yttrium 88 ( 88 Y), which would have produced significantly younger age estimates? (icr.org)
  • Cobalt is a naturally-occurring element that has properties similar to those of iron and nickel. (cdc.gov)
  • The silica content is important because the composition of the continental crust is predominantly silica, while the early Earth's crust was likely mafic, or composed of predominantly iron and magnesium. (phys.org)
  • Methods for synthesizing appropriate labels and for detecting isotopes of iron and tin directly on polyacrylamide gels are described. (spie.org)
  • The attributes of naturally decaying atoms, known as radioisotopes, give rise to several applications across many aspects of modern day life (see also information paper on The Many Uses of Nuclear Technology ). (world-nuclear.org)
  • Radioiron binds to transferrin, an alpha-1 globulin, which has the capacity of accepting two atoms of iron per molecule of protein. (annals.org)
  • What is the ratio of iron atoms to oxygen atoms in this compound? (bartleby.com)
  • Vitamin B 12 can be tagged with a radioisotope of cobalt to study the absorption of the vitamin from the gastrointestinal tract. (kentchemistry.com)
  • John J. Livingood and I discovered radioisotopes, including iodine-131 and cobalt-60, that are crucial to the diagnosis and treatment of many life-threatening diseases. (lbl.gov)
  • 75 or 88 or 107, speaking as we find 1675 substances( online Clinical and Radiological Aspects of Myopathies: CT Scanning · EMG · Radioisotopes 1982. (ballroomchicago.com)
  • This online Clinical and Radiological Aspects of Myopathies: CT Scanning · EMG · Radioisotopes 1982 is Apocrypha to the video century of the political ice through an textual n. of sites between East and West, South and North. (ballroomchicago.com)
  • Manganese and iron from underwater volcanic eruptions can also contribute to nodule growth, as can the presence of algae and bacteria. (icr.org)
  • During its transport in the plasma, iron is removed from the plasma at an exponential rate into the bone marrow where it is soon utilized in hemoglobin synthesis. (annals.org)
  • Iron is chiefly important to the human body because it is the main constituent of hemoglobin , cytochrome , and other components of respiratory enzyme systems. (thefreedictionary.com)
  • Although babies are born with an extra supply of hemoglobin, by the age of 2 or 3 months they need iron-rich food to supplement milk. (thefreedictionary.com)
  • Transferrin binds to red blood precursors in the bone marrow and delivers iron for incorporation into hemoglobin. (thefreedictionary.com)
  • In addition, we highlight two occurrences among fish living in iron-poor regions that would conceivably be beneficial given iron scarcity: the absence of hemoglobin in Antarctic icefish, and the anadromous life history of salmon. (frontiersin.org)
  • And in fact there is a study that's also looked at hemoglobin regeneration taking anemic patients seeing what their hemoglobin was after a period of time, four week, six weeks whatever and seeing what the hemoglobin response has been, from there we know that each gram of hemoglobin requires a 150 mg of irons. (ihealthtube.com)
  • Come back three months later hemoglobin still low the dose gets bumped up or the doctor say oral iron is useless. (ihealthtube.com)
  • Radioisotope Dating of Meteorites: IV. (answersingenesis.org)
  • This third paper documents the radioisotope dating data for more meteorites, so as to continue the discussion of the significance of these data. (answersingenesis.org)
  • Besides histological types, the size, necrosis, vascularity and treatments of liver cancer, concentrations of transferrin (/sup 67/Ga binding protein) and iron in blood probably affected /sup 67/Ga accumulation in liver cancer. (osti.gov)
  • As previously reported, iron parameters were modulated by genetic background with significantly higher values for plasma iron parameters and liver iron concentration in DBA/2 and Balb/c strains. (springer.com)
  • Coppin H et al (2007) Gene expression profiling of Hfe −/− liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers. (springer.com)
  • From the intestine, iron is transported on transferrin to the liver or the bone marrow. (thefreedictionary.com)
  • Approximately 20 percent to 30 percent of iron is stored in the form of hemosiderin in the spleen, liver, and bone marrow. (thefreedictionary.com)
  • Seventeen patients with cirrhosis of the liver were studied using either labelled ferrous sulphate or labelled haemoglobin iron. (bl.uk)
  • While IONP-based agents are highly biocompatible, and are in fact used for clinically treating iron deficiency, there are increasing concerns about poor clearance and long liver retention time for the large IONPs (i.e., 10-50 nm core) currently used in biomedical imaging applications. (sigmaaldrich.com)
  • 1997). Based on radioisotope measurements of ascorbic acid kinetics, the lungs appear to be a smaller but rapidly mobilized vitamin C pool, while the liver and muscle are larger, more slowly mobilized reserves (Toutain et al. (dsm.com)
  • There is widespread awareness of the use of radiation and radioisotopes in medicine, particularly for diagnosis (identification) and therapy (treatment) of various medical conditions. (world-nuclear.org)
  • 1992). The use of radioisotopes is unique in that it provides a method for measuring biochemical processes in vivo, especially in cases in which the process is easily saturated, since radiation makes it possible to detect and localize quantities as small as only a few thousand radiolabeled molecules. (nap.edu)
  • Metal complexes can be used either for radioisotope imaging (from their emitted radiation) or as contrast agents, for example, in magnetic resonance imaging (MRI). (wikipedia.org)
  • The use of radioisotopes as a basis for radiophysical instrumental methods of analysis can be exemplified by the following: Iron-55 emits a K-capture electron from the nucleus whose radiation can be absorbed by a sulfur atom regardless of its chemical combination. (astm.org)
  • The use of radioisotope exposes patients and healthcare workers to radiation, is heavily controlled by legislation (both on the specific training for operators and subsequent disposal of surgical waste), and provides poor pre-operative imaging. (isrctn.com)
  • Iron is reported to interact with other metals. (springer.com)
  • Our objective was to characterize, in mice of three genetic backgrounds, the links between iron and several non-iron metals. (springer.com)
  • Principal component analysis of the data obtained for non-iron metals indicated that metals parameters stratified the mice according to their genetic background. (springer.com)
  • Moreover, relationships were found between plasma and tissue content of iron and some other metals parameters. (springer.com)
  • Gadolinium(III), Iron(III), Manganese(II): For MRI imaging paramagnetic metals are needed for contrast imaging. (wikipedia.org)
  • The effects of solution variables such as ph, oxygen partial pressure, and ferric iron concentration at different temperatures were measured. (cdc.gov)
  • The radioisotopes produced by the inventive method are especially suitable for producing radioisotope-labelled bioconjugates as well as particles, in particular nanoparticles and microparticles. (freepatentsonline.com)
  • Knowing the rate of energy loss allowed the researchers to calculate how long it would take to get a solid mass the size of today's core from a blob of molten iron. (space.com)
  • All the moon dynamo theories assume that the earth's magnetic field is produced by a dynamo, meaning that motions of the molten iron (too hot to be magnetic) in the earth's outer core would somehow act like an electric generator that produces its own magnetic field. (creation.com)
  • Even if the earth really were to have a working dynamo, the moon's core (probably also molten iron) is ten times smaller and rotates thirty times slower. (creation.com)
  • The iron for the three complexes was in temperature-independent high spin state by 57 Fe Mössbauer spectroscopy and magnetic susceptibility measurement. (mdpi.com)
  • However, when the iron concentration in water samples is extremely low, XAFS measurement and analysis can be difficult due to so much noise in the spectra. (iwaponline.com)
  • These results showed that the chemical form of the iron of the actual water samples taken from the water pipes was able to be detected from the XAFS measurement. (iwaponline.com)
  • A practical procedure is described for the measurement of sulfur in all forms (SO 2 , SO 3 , S 2 O 3 , RSH, R 2 S, RSSR, etc.) by using an uncalibrated source of iron-55, a sample holder, a suitable absorption cell, and an appropriate detecting instrument. (astm.org)
  • I used the radioisotopes iron-55 and iron-59, manganese-52, and zinc-65 as tracers. (gf.org)
  • An P et al (2012) TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia. (springer.com)
  • and iron deficiency anemia , a serious condition characterized by low to absent iron stores, low hematocrit, and other blood abnormalities. (thefreedictionary.com)
  • Ferumoxytol is a SPION recently approved by the U.S. Food and Drug Administration to treat iron-deficiency anemia in chronic kidney disease. (nih.gov)
  • The use of radioisotope with or without blue dye has long become the gold standard for sentinel lymph node localization in the management of breast cancer. (clinicaltrials.gov)
  • The standard Sentinel Lymph Node Biopsy (SLNB) technique (patent blue dye and radioisotope) used in melanoma patients has several drawbacks. (isrctn.com)
  • 30 mL of a solution of iron and ascorbic acid as reference dose and 200 mL of full fat cow's milk fortified with iron as ferrous sulfate. (mdpi.com)
  • The most common radioisotope used in diagnosis is technetium-99 (Tc-99), with some 40 million procedures per year, accounting for about 80% of all nuclear medicine procedures and 85% of diagnostic scans in nuclear medicine worldwide. (world-nuclear.org)
  • But now, researchers at Pacific Northwest National Laboratory (PNNL), Florida International University, and the Illinois Institute of Technology are closer to understanding how high concentrations of technetium-99 can be treated by simple iron , which is inexpensive and readily available. (phys.org)
  • The latter, also known as radioisotopes, play a significant role in modern life. (encyclopedia.com)
  • Iron: iron toxicity, iron poisoning, or iron overload is well known. (wikipedia.org)
  • A great loss of blood, such as may result from bleeding ulcers, hemorrhoids, or injury, is the most common cause of a deficiency of iron. (thefreedictionary.com)
  • Iron deficiency sometimes occurs in pregnancy as a result of increased demands on the mother's blood. (thefreedictionary.com)
  • An acute iron deficiency may warrant parenteral administration of an iron supplement. (thefreedictionary.com)
  • Twenty patients with iron-deficiency anaemia went also given iron absorption tests. (bl.uk)
  • Data from 61 normal control subjects and 46 patients with iron-deficiency anaemia was used in defining a range of absorption in normal and iron-deficient subjects. (bl.uk)
  • Radionuclides (or sometimes, radioisotopes) are unstable atomic nuclei, and they spontaneously "fall apart" by various means because of their unstable nature. (answers.com)
  • But stars can't make nuclei heavier than iron during the course of "regular" stellar nucleosynthesis. (answers.com)
  • Thus a 4 Ga radioisotope age, being close to the 4.5 Ga alleged for the age of the solar system, would have a real date from close to, or in, the Creation Week, about 6,000 years ago. (creation.com)
  • Enterobactin, the native siderophore of Escherichia coli and the most avid microbial iron chelator (K a = 10 52 [ 10 ]) contains three dihydroxybenzoyl serine groups linked in a macrocyclic lactone ring (Fig. 1 ). (asm.org)
  • Unlike the sample they tested, the core isn't just iron - it also contains lighter elements such as carbon , hydrogen , oxygen , silicon and sulfur. (space.com)
  • Iron is an essential element for virtually all organisms, playing a central role in many components of the photosynthetic machinery, respiratory reactions, DNA synthesis, and for the transport and storage of oxygen. (frontiersin.org)
  • Let's begin by talking about what is known about bioavailability of conventional ferrous salts, things like ferrous sulfate, ferrous fumarate, even some of the polysaccharide irons. (ihealthtube.com)
  • MIT Professor of Nutrition Robert S. Harris led the experiment, which studied the absorption of calcium and iron. (wikipedia.org)
  • In this study, we examined various conditions related to XAFS measurements to analyze the chemical form of iron in water taken from water pipes. (iwaponline.com)
  • Differences were observed in the XAFS spectra depending on the chemical form of iron. (iwaponline.com)
  • Many researchers have tried to measure the chemical form of iron in water pipes. (iwaponline.com)
  • Although there is much information on the chemical form of iron present in pipes, X-ray diffraction was the primary method of analysis, in which samples had to be dried in the pretreatment. (iwaponline.com)
  • This occurs as the iron oxidizes or loses electrons in a chemical process called reductive removal. (phys.org)
  • Stable isotopes can be used as alternatives to radioisotopes or fluorescent DNA labels. (spie.org)
  • 26 Iron is considered stable, but higher then 84 Polonium is considered active. (answers.com)
  • However, the availability of iron is not typically considered an important factor in the ecology of marine animals, including fish. (frontiersin.org)
  • The purpose of this study was to measure the bioavailability of two iron fortified milk formulas designed to cover toddlers´ nutritional needs. (mdpi.com)
  • Dr. Bortz: So the bioavailability is a sort of a first question that most people want to know about with any ingredients and iron is no exception. (ihealthtube.com)
  • Several studies have demonstrated you know, in early 2000 era that the bioavailability of chelates, ferrous bisglycinate has been the most studied iron chelate. (ihealthtube.com)
  • But you have something important Scot and that is that most of the bioavailability studies of the salts in most irons have been single dosing studies, which means that bring in subjects, take blood, give them one tablet or whatever dose or a solution that have an amount of iron and then they measure the amount of iron that appears in their blood over the course of the next 24 hours. (ihealthtube.com)
  • Background: Fortification of milk formulas with iron is a strategy widely used, but the absorption of non-heme iron is low. (mdpi.com)
  • Low dissolved iron concentrations are widely recognized to play a role in limiting the growth of marine phytoplankton ( Marchetti and Maldonado, 2016 ), most importantly in the high nitrate low chlorophyll (HNLC) regions that constitute more than one quarter of the open ocean surface ( Sarmiento and Gruber, 2006 ) ( Figure 1 ). (frontiersin.org)
  • All the naturally occurring trans-iron elements through uranium are created by this mighty crushing event, and they're distributed out into the galaxy by the following blast. (answers.com)
  • Over 40 million nuclear medicine procedures are performed each year, and demand for radioisotopes is increasing at up to 5% annually. (world-nuclear.org)
  • In developed countries (a quarter of the world population) about one person in 50 uses diagnostic nuclear medicine each year, and the frequency of therapy with radioisotopes is about one-tenth of this. (world-nuclear.org)
  • During the late 1930's, my co-workers and I discovered a number of radioisotopes that have become the workhorses of nuclear medicine. (lbl.gov)
  • In all, eight radioisotopes used in nuclear medicine were discovered by my co-workers and me. (lbl.gov)
  • Hypersensitivity to iron supplements often occurs in patients with other known allergies. (thefreedictionary.com)
  • Iron granules (left) after one month of contact with technetium. (phys.org)
  • Iron granules at the bottom react in a solution containing technetium at PNNL. (pnnl.gov)
  • In the wild, the low solubility of iron in aqueous, aerobic conditions further complicates its acquisition: the concentration of available Fe 3+ at neutrality is 10 −18 M ( 34 ), whereas bacteria require a minimum of 10 −8 M for growth and 10 −6 M for iron sufficiency ( 24 ). (asm.org)
  • It has a short half-life, emits only gamma ray photons, and does not emit beta or alpha particles (which are more damaging to surrounding cells), and thus is particularly suitable as an imaging radioisotope. (wikipedia.org)
  • In the seven iron-laden patients the mean absorption of labelled haemoglobin was 12 per cent. (bl.uk)
  • Its three identical catechol groups chelate Fe 3+ in a Δ- cis complex, creating a hexadentate iron center with a net charge of −3. (asm.org)
  • The fact that this experiment was conducted in conditions that would spontaneously occur with the introduction of iron, known as zero valent iron, has positive implications for environmental cleanup efforts in the subsurface or nuclear waste treatment systems," said corresponding author Tatiana Levitskaia, a chemist at PNNL. (phys.org)
  • The latest evidence from a number of European trials has proven that a new tracer agent, superparamagnetic iron oxide particles (SPIOs, Sienna+®), is non-inferior to the standard method of lymphatic mapping. (clinicaltrials.gov)
  • The team recently completed experiments in which almost all-99.8%-of the technetium was removed from a liquid solution after one month in contact with iron particles. (phys.org)
  • The experiments refuted the idea that chirality of the iron complex affects its recognition by FepA and demonstrated the necessity of an unsubstituted catecholate coordination center for binding to the outer membrane protein. (asm.org)
  • In diffusion experiments the radioisotopes 54Mn, 51Cr and 59Fe were used. (scientific.net)
  • AC3 plant absorbs a carbon radioisotope (as part of 14CO2). (bartleby.com)
  • Researchers revealed in Communications Chemistry that clusters of technetium partially incorporate into iron minerals, such as magnetite, during simultaneous iron oxidation and mineralization. (phys.org)
  • Researchers also found that the presence of technetium slows the oxidation of the metallic iron and its ultimate transformation from ferrihydrite to magnetite. (phys.org)
  • Researchers revealed in the Nature Research journal Communications Chemistry that clusters of technetium partially incorporate into iron minerals, such as magnetite, during simultaneous iron oxidation and mineralization. (pnnl.gov)
  • Now, researchers have squeezed a miniscule piece of iron between two diamonds and blasted it with lasers to arrive at a new estimate of 1 billion to 1.3 billion years old - a date range that coincides with a measurable strengthening of the Earth's magnetic field that happened around the same time. (space.com)
  • Researchers currently track whether cells reach their destinations using radioisotopes or by implanting a "reporter" gene. (nih.gov)
  • The increasing use of radioisotopes in clinical medicine offers better means of understanding and quantitating physiological processes. (annals.org)
  • Although these amounts are very small, iron deficiencies may cause serious disorders. (thefreedictionary.com)
  • Jan 2010- 49 Which radioisotope is used to treat thyroid disorders? (kentchemistry.com)