Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Radioisotopes: Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Zinc Radioisotopes: Unstable isotopes of zinc that decay or disintegrate emitting radiation. Zn atoms with atomic weights 60-63, 65, 69, 71, and 72 are radioactive zinc isotopes.Iodine Compounds: Inorganic compounds that contain iodine as an integral part of the molecule.Radioisotope Dilution Technique: Method for assessing flow through a system by injection of a known quantity of radionuclide into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)Strontium Radioisotopes: Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.Krypton Radioisotopes: Unstable isotopes of krypton that decay or disintegrate emitting radiation. Kr atoms with atomic weights 74-77, 79, 81, 85, and 87-94 are radioactive krypton isotopes.Goiter, Endemic: A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.Indium Radioisotopes: Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.Goiter: Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).Sodium Radioisotopes: Unstable isotopes of sodium that decay or disintegrate emitting radiation. Na atoms with atomic weights 20-22 and 24-26 are radioactive sodium isotopes.Radionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Radioactivity: The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Barium Radioisotopes: Unstable isotopes of barium that decay or disintegrate emitting radiation. Ba atoms with atomic weights 126-129, 131, 133, and 139-143 are radioactive barium isotopes.Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.Tin Radioisotopes: Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.Carbon Radioisotopes: Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.Iron Radioisotopes: Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.Copper Radioisotopes: Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.Potassium Iodide: An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)Beta Particles: High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.Sodium Chloride, Dietary: Sodium chloride used in foods.Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.Mercury Radioisotopes: Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.Technetium Tc 99m Sulfur Colloid: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.Cesium Isotopes: Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.Isotope Labeling: Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.Povidone-Iodine: An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.Cerium Radioisotopes: Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.Cobalt Isotopes: Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.Deficiency Diseases: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)Hafnium: Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)Gold Radioisotopes: Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.Radioimmunotherapy: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).Lead Radioisotopes: Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.Diagnostic Techniques, Radioisotope: Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.Astatine: Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.Zinc Isotopes: Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.Sulfur Radioisotopes: Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.Cadmium Radioisotopes: Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Iodides: Inorganic binary compounds of iodine or the I- ion.Iodophors: Complexes of iodine and non-ionic SURFACE-ACTIVE AGENTS acting as carrier and solubilizing agent for the iodine in water. Iodophors usually enhance bactericidal activity of iodine, reduce vapor pressure and odor, minimize staining, and allow wide dilution with water. (From Merck Index, 11th ed)Soil Pollutants, Radioactive: Pollutants, present in soil, which exhibit radioactivity.Lutetium: Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.Rhenium: Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)Thyrotropin: A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.Bromine Radioisotopes: Unstable isotopes of bromine that decay or disintegrate emitting radiation. Br atoms with atomic weights 74-78, 80, and 82-90 are radioactive bromine isotopes.Samarium: Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.Scintillation Counting: Detection and counting of scintillations produced in a fluorescent material by ionizing radiation.Subdural Effusion: Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.Calcium Isotopes: Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.Radioactive Waste: Liquid, solid, or gaseous waste resulting from mining of radioactive ore, production of reactor fuel materials, reactor operation, processing of irradiated reactor fuels, and related operations, and from use of radioactive materials in research, industry, and medicine. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Congenital Hypothyroidism: A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA.Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.Ruthenium Radioisotopes: Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.Thyroid Function Tests: Blood tests used to evaluate the functioning of the thyroid gland.Iodized Oil: A preparation of oil that contains covalently bound IODINE. It is commonly used as a RADIOCONTRAST AGENT and as a suspension medium for CHEMOTHERAPEUTIC AGENTS.Radiometric Dating: Techniques used to determine the age of materials, based on the content and half-lives of the RADIOACTIVE ISOTOPES they contain.ThyroglobulinIodine Isotopes: Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.Selenium Radioisotopes: Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.Alpha Particles: Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.Methods: A series of steps taken in order to conduct research.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Heterocyclic Compounds, 1-Ring: A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.Sodium Pertechnetate Tc 99m: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.Tungsten: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.Thyroid Diseases: Pathological processes involving the THYROID GLAND.Isotopes: Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)Radioisotope Teletherapy: A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.Whole-Body Counting: Measurement of radioactivity in the entire human body.Spectrometry, Gamma: Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)IodoproteinsNuclear Medicine: A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Thyroid Hormones: Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).TritiumHyperthyroidism: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.Nostoc commune: A form species of spore-producing CYANOBACTERIA, in the family Nostocaceae, order Nostocales. It is an important source of fixed NITROGEN in nutrient-depleted soils. When wet, it appears as a jelly-like mass.Iodide Peroxidase: A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.Cesium Radioisotopes: Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes.Potassium Radioisotopes: Unstable isotopes of potassium that decay or disintegrate emitting radiation. K atoms with atomic weights 37, 38, 40, and 42-45 are radioactive potassium isotopes.Iodohippuric Acid: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.Perchlorates: Compounds that contain the Cl(=O)(=O)(=O)O- structure. Included under this heading is perchloric acid and the salts and ester forms of perchlorate.Carbon Isotopes: Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Diiodotyrosine: A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Sodium Iodide: A compound forming white, odorless deliquescent crystals and used as iodine supplement, expectorant or in its radioactive (I-131) form as an diagnostic aid, particularly for thyroid function tests.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Anti-Infective Agents, Local: Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Nutritional Status: State of the body in relation to the consumption and utilization of nutrients.Iodates: Inorganic salts of iodic acid (HIO3).Monoiodotyrosine: A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.Republic of BelarusThyroiditis, Autoimmune: Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis.Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.Sentinel Lymph Node Biopsy: A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Autoradiography: The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)Bismuth: A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.Avidin: A specific protein in egg albumin that interacts with BIOTIN to render it unavailable to mammals, thereby producing biotin deficiency.Time Factors: Elements of limited time intervals, contributing to particular results or situations.

99mTc-labeled vasoactive intestinal peptide receptor agonist: functional studies. (1/6522)

Vasoactive intestinal peptide (VIP) is a naturally occurring 28-amino acid peptide with a wide range of biological activities. Recent reports suggest that VIP receptors are expressed on a variety of malignant tumor cells and that the receptor density is higher than for somatostatin. Our aims were to label VIP with 99mTc--a generator-produced, inexpensive radionuclide that possesses ideal characteristics for scintigraphic imaging--and to evaluate 99mTc-VIP for bioactivity and its ability to detect experimental tumors. METHODS: VIP28 was modified at the carboxy terminus by the addition of four amino acids that provided an N4 configuration for a strong chelation of 99mTc. To eliminate steric hindrance, 4-aminobutyric acid (Aba) was used as a spacer. VIP28 was labeled with 1251, which served as a control. Biological activity of the modified VIP28 agonist (TP3654) was examined in vitro using a cell-binding assay and an opossum internal anal sphincter (IAS) smooth muscle relaxivity assay. Tissue distribution studies were performed at 4 and 24 h after injection, and receptor-blocking assays were also performed in nude mice bearing human colorectal cancer LS174T. Blood clearance was examined in normal Sprague-Dawley rats. RESULTS: The yield of 99mTc-TP3654 was quantitative, and the yields of 125I-VIP and 1251-TP3654 were >90%. All in vitro data strongly suggested that the biological activity of 99mTc-TP3654 agonist was equivalent to that of VIP28. As the time after injection increased, radioactivity in all tissues decreased, except in the receptor-enriched tumor (P = 0.84) and in the lungs (P = 0.78). The tumor uptake (0.23 percentage injected dose per gram of tissue [%ID/g]) was several-fold higher than 125I-VIP (0.06 %ID/g) at 24 h after injection in the similar system. In mice treated with unlabeled VIP or TP3654, the uptake of 99mTc-TP3654 decreased in all VIP receptor-rich tissues except the kidneys. The blood clearance was biphasic; the alpha half-time was 5 min and the beta half-time was approximately 120 min. CONCLUSION: VIP28 was modified and successfully labeled with 99mTc. The results of all in vitro examinations indicated that the biological activity of TP3654 was equivalent to that of native VIP28 and tumor binding was receptor specific.  (+info)

Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. (2/6522)

Previous studies have shown that autoimmune thyroiditis can be induced in normal laboratory rats after thymectomy and split dose gamma-irradiation. Development of disease can be prevented by reconstitution of PVG rats shortly after their final irradiation with either peripheral CD4(+)CD45RC- T cells or CD4(+)CD8(-) thymocytes from syngeneic donors. Although the activity of both populations is known to depend on the activities of endogenously produced interleukin 4 and transforming growth factor beta, implying a common mechanism, the issue of antigen specificity of the cells involved has not yet been addressed. In this study, we show that the regulatory T cells that prevent autoimmune thyroiditis are generated in vivo only when the relevant autoantigen is also present. Peripheral CD4(+) T cells, from rats whose thyroids were ablated in utero by treatment with 131I, were unable to prevent disease development upon adoptive transfer into thymectomized and irradiated recipients. This regulatory deficit is specific for thyroid autoimmunity, since CD4(+) T cells from 131I-treated PVG.RT1(u) rats were as effective as those from normal donors at preventing diabetes in thymectomized and irradiated PVG.RT1(u) rats. Significantly, in contrast to the peripheral CD4(+) T cells, CD4(+)CD8(-) thymocytes from 131I-treated PVG donors were still able to prevent thyroiditis upon adoptive transfer. Taken together, these data indicate that it is the peripheral autoantigen itself that stimulates the generation of the appropriate regulatory cells from thymic emigrant precursors.  (+info)

Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin. (3/6522)

1. Proliferative effects of CCK peptides have been examined in rat anterior pituitary GH3 cells, which express CCK2 receptors. 2. CCK-8s, gastrin(1-17) and its glycine-extended precursor G(1-17)-Gly, previously reported to cause proliferation via putative novel sites on AR4-2J and Swiss 3T3 cells, elicited significant dose dependent increases of similar magnitude in [3H]thymidine incorporation over 3 days in serum-free medium of 39 +/- 10% (P < 0.01, n = 20), 37 +/- 8% (P < 0.01, n = 27) and 41 +/- 6% (P < 0.01, n = 36) respectively. 3. CCK-8s and gastrin potentially stimulated mitogenesis (EC50 values 0.12 nM and 3.0 nM respectively), whilst G-Gly displayed similar efficacy but markedly lower potency. L-365,260 consistently blocked each peptide. The CCK2 receptor affinity of G-Gly in GH3 cells was 1.09 microM (1.01;1.17, n = 6) and 5.53 microM (3.71;5.99, n = 4) in guinea-pig cortex. 4. 1 microM G-Gly weakly stimulated Ca2+ increase, eliciting a 104 +/- 21% increase over basal Ca2+ levels, and was blocked by 1 microM L-365,260 whilst CCK-8s (100 nM) produced a much larger Ca2+ response (331 +/- 14%). 5. Insulin dose dependently enhanced proliferative effects of CCK-8s with a maximal leftwards shift of the CCK-8s curve at 100 ng ml(-1) (17 nM) (EC50 decreased 500 fold, from 0.1 nM to 0.2 pM; P < 0.0001). 10 microg ml(-1) insulin was supramaximal reducing the EC50 to 5 pM (P = 0.027) whilst 1 ng ml(-1) insulin was ineffective. Insulin weakly displaced [125I]BHCCK binding to GH3 CCK2 receptors (IC50 3.6 microM). 6. Results are consistent with mediation of G-Gly effects via CCK2 receptors in GH3 cells and reinforce the role of CCK2 receptors in control of cell growth. Effects of insulin in enhancing CCK proliferative potency may suggest that CCK2 and insulin receptors converge on common intracellular targets and indicates that mitogenic stimuli are influenced by the combination of extracellular factors present.  (+info)

Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs. (4/6522)

Conjugation of drugs with antibodies to surface endothelial antigens is a potential strategy for drug delivery to endothelium. We studied antibodies to platelet-endothelial adhesion molecule 1 (PECAM-1, a stably expressed endothelial antigen) as carriers for vascular immunotargeting. Although 125I-labeled anti-PECAM bound to endothelial cells in culture, the antibody was poorly internalized by the cells and accumulated poorly after intravenous administration in mice and rats. However, conjugation of biotinylated anti-PECAM (b-anti-PECAM) with streptavidin (SA) markedly stimulated uptake and internalization of anti-PECAM by endothelial cells and by cells expressing PECAM. In addition, conjugation with streptavidin markedly stimulated uptake of 125I-labeled b-anti-PECAM in perfused rat lungs and in the lungs of intact animals after either intravenous or intraarterial injection. The antioxidant enzyme catalase conjugated with b-anti-PECAM/SA bound to endothelial cells in culture, entered the cells, escaped intracellular degradation, and protected the cells against H2O2-induced injury. Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury. Thus, modification of a poor carrier antibody with biotin and SA provides an approach for facilitation of antibody-mediated drug targeting. Anti-PECAM/SA is a promising candidate for vascular immunotargeting of bioactive drugs.  (+info)

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. (5/6522)

Steroid hormones may enter cells by diffusion through the plasma membrane. However, we demonstrate here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. We show that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation of 1,25-(OH)2 vitamin D3, a regulator of the calcium metabolism. Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.  (+info)

Conformational changes in the A3 domain of von Willebrand factor modulate the interaction of the A1 domain with platelet glycoprotein Ib. (6/6522)

Bitiscetin has recently been shown to induce von Willebrand factor (vWF)-dependent aggregation of fixed platelets (Hamako J, et al, Biochem Biophys Res Commun 226:273, 1996). We have purified bitiscetin from Bitis arietans venom and investigated the mechanism whereby it promotes a form of vWF that is reactive with platelets. In the presence of bitiscetin, vWF binds to platelets in a dose-dependent and saturable manner. The binding of vWF to platelets involves glycoprotein (GP) Ib because it was totally blocked by monoclonal antibody (MoAb) 6D1 directed towards the vWF-binding site of GPIb. The binding also involves the GPIb-binding site of vWF located on the A1 domain because it was inhibited by MoAb to vWF whose epitopes are within this domain and that block binding of vWF to platelets induced by ristocetin or botrocetin. However, in contrast to ristocetin or botrocetin, the binding site of bitiscetin does not reside within the A1 domain but within the A3 domain of vWF. Thus, among a series of vWF fragments, 125I-bitiscetin only binds to those that overlap the A3 domain, ie, SpIII (amino acid [aa] 1-1365), SpI (aa 911-1365), and rvWF-A3 domain (aa 920-1111). It does not bind to SpII corresponding to the C-terminal part of vWF subunit (aa 1366-2050) nor to the 39/34/kD dispase species (aa 480-718) or T116 (aa 449-728) overlapping the A1 domain. In addition, bitiscetin that does not bind to DeltaA3-rvWF (deleted between aa 910-1113) has no binding site ouside the A3 domain. The localization of the binding site of bitiscetin within the A3 domain was further supported by showing that MoAb to vWF, which are specific for this domain and block the interaction between vWF and collagen, are potent inhibitors of the binding of bitiscetin to vWF and consequently of the bitiscetin-induced binding of vWF to platelets. Thus, our data support the hypothesis that an interaction between the A1 and A3 domains exists that may play a role in the function of vWF by regulating the ability of the A1 domain to bind to platelet GPIb.  (+info)

Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat. (7/6522)

The objective of this study was to determine the relative roles of arachnoid villi and cervical lymphatics in the clearance of a cerebrospinal fluid (CSF) tracer in rats. 125I-labeled human serum albumin (125I-HSA; 100 micrograms) was injected into one lateral ventricle, and an Evans blue dye-rat protein complex was injected intravenously. Arterial blood was sampled for 3 h. Immediately after this, multiple cervical vessels were ligated in the same animals, and plasma recoveries were monitored for a further 3 h after the intracerebroventricular injection of 100 micrograms 131I-HSA. Tracer recovery in plasma at 3 h averaged (%injected dose) 0.697 +/- 0.042 before lymphatic ligation and dropped significantly to 0.357 +/- 0. 060 after ligation. Estimates of the rate constant associated with the transport of the CSF tracer to plasma were also significantly lower after obstruction of cervical lymphatics (from 0.584 +/- 0. 072/h to 0.217 +/- 0.056/h). No significant changes were observed in sham-operated animals. Assuming that the movement of the CSF tracer to plasma in lymph-ligated animals was a result of arachnoid villi clearance, we conclude that arachnoid villi and extracranial lymphatic pathways contributed equally to the clearance of the CSF tracer from the cranial vault.  (+info)

Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG). (8/6522)

meta-iodobenzylguanidine (MIBG) radiolabelled with iodine-131 is used for diagnosis and treatment of neuroadrenergic neoplasms such as phaeochromocytoma and neuroblastoma. In addition, non-radiolabelled MIBG, administered i.v., is used in several clinical studies. These include palliation of the carcinoid syndrome, in which MIBG proved to be effective in 60% of the patients. Oral MIBG administration might be convenient to maintain palliation and possibly improve the percentage of responders. We have, therefore, investigated the feasibility of oral administration of MIBG in an animal model. Orally administered MIBG demonstrated a bioavailability of 59%, with a maximal tolerated dose of 60 mg kg(-1). The first and only toxicity encountered was a decrease in renal function, measured by a reduced clearance of [51Cr]EDTA and accompanied by histological tubular damage. Repeated MIBG administration of 40 mg kg(-1) for 5 sequential days or of 20 mg kg(-1) for two courses of 5 sequential days with a 2-day interval did not affect renal clearance and was not accompanied by histological abnormalities in kidney, stomach, intestines, liver, heart, lungs, thymus, salivary glands and testes. Because of a sufficient bioavailability in absence of gastrointestinal toxicity, MIBG is considered suitable for further clinical investigation of repeated oral administration in patients.  (+info)

*Iobenguane

The radioisotope of iodine used for the label can be iodine-123 (for imaging purposes only) or iodine-131 (which must be used ... Iodine-131 iobenguane used for therapeutic purposes requires a different pre-medication duration, beginning 24-48 hours prior ... Product labeling for diagnostic iodine-131 iobenguane recommends potassium iodide administration one day before injection and ... Commercially available iobenguane is labeled with iodine-123, and product labeling recommends administration of potassium ...

*Tositumomab

Combined with radioisotope iodine 131 it was called Iodine I 131 Tositumomab. Unlabelled tositumomab together with iodine- ... Tositumomab and iodine I 131 tositumomab (Bexaar). AJNR Am J Neuroradiol. 2011 Apr;32(4):637-8. PMID 21436340. Free full text ...

*Iodine-131

... other less-damaging radioisotopes of iodine such as iodine-123 (see isotopes of iodine) are preferred in situations when only ... Iodine-131 (131I) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the ... Iodine Isotopes of iodine Iodine in biology Iodide Potassium iodide "UW-L Brachy Course". wikifoundry. April 2008. Retrieved ... where the low-energy gamma radiation without a beta component makes iodine-125 useful. The other radioisotopes of iodine are ...

*Isotopes of iodine

Radioisotopes of iodine are called radioactive iodine or radioiodine. Dozens exist, but about a half dozen are the most notable ... Iodine fission-produced isotopes not discussed above (iodine-128, iodine-130, iodine-132, and iodine-133) have a half lives of ... Iodine isotopes data from The Berkeley Laboratory Isotopes Project's Iodine-128, Iodine-130, Iodine-132 data from 'Wolframalpha ... Of the many isotopes of iodine, only two are typically used in a medical setting: iodine-123 and iodine-131. Since 131I has ...

*3F8

For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131. Monoclonal antibody therapy ... 1991). "Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine ...

*Philadelphia Water Department

"Radioisotope Brief Iodine-131" (PDF). CDC. August 18, 2005. Retrieved April 24, 2012. Jack E. Whitten, Steven R. Courtemanche, ... Iodine-131 is used to diagnose and treat thyroid cancer, is produced via nuclear fission, is a byproduct of nuclear power and ... Iodine-131 also is a byproduct of nuclear power plants. But officials have ruled out the Limerick nuclear power plant, located ... Iodine-131 is also used in annual tests for leaks in injection wells containing waste. Originally the elevated levels were ...

*List of MeSH codes (D01)

... gold radioisotopes MeSH D01.496.381.550.400 --- gold colloid, radioactive MeSH D01.496.448.496 --- iodine radioisotopes MeSH ... indium radioisotopes MeSH D01.496.749.474 --- iodine radioisotopes MeSH D01.496.749.474.665 --- serum albumin, radio-iodinated ... calcium radioisotopes MeSH D01.496.123.328 --- carbon radioisotopes MeSH D01.496.156.300 --- cerium radioisotopes MeSH D01.496. ... calcium radioisotopes MeSH D01.496.749.154 --- carbon radioisotopes MeSH D01.496.749.185 --- cerium radioisotopes MeSH D01.496. ...

*Peregrine Pharmaceuticals

... conjugated to the radioisotope iodine-131. As of 2016 Peregrine was developing it for Glioblastoma multiforme; it has been ... 2 fully human monoclonal antibody fragment joined to the PET imaging radio-isotope iodine-124 being developed to obtain medical ...

*Chernobyl necklace

Because of this function, radioisotopes of iodine are concentrated in the thyroid gland along with nonradioactive iodine. In ... Iodine is required by higher animals to synthesize thyroid hormones, which contain the element. ... the case of a nuclear accident, the radioactive iodine-131 (I-131), which has a high fission product yield, is released into ...

*DASB

With single-photon emission computed tomography (SPECT) using the radioisotope iodine-123 there are further radioligands ...

*List of civilian radiation accidents

A gaseous leak of a radioisotope of iodine, 131I, was detected at a large medical radioisotope laboratory, Institut national ... A radioisotope thermoelectric generator (RTG) located on the Arctic shore was discovered in a highly degraded state. The ... Two radioisotope thermoelectric generators were dropped 50 meters onto the tundra at Zemlya Bunge island during an airlift when ... IAEA NEWS database: Iodine-131 release in the environment Archived June 4, 2011, at the Wayback Machine. Domino, Donna (2008-11 ...

*Marshall Brucer

Brucer told a conference that the use of radio-isotopes of iodine, gold and phosphorus was becoming increasingly commonplace. ... He said that shipments of radioactive drugs from Oak Ridge numbered 50,000 units of radio-iodine, 50,000 units of radio-gold ... They were given atomic "cocktails" to drink and injections of radio-isotopes, and became temporarily radioactive. While not ... and was acting as an editor of the International Journal of Applied Radiation and Radioisotopes. In 1967, Brucer was appointed ...

*History of radiation therapy

... though technically all radioisotopes of iodine are radioiodines; see isotopes of iodine). Pusey 1900, p. 302 Kassabian 1907, p ... and some types of thyroid cancer that absorb iodine. Treatment involves the important iodine isotope iodine-131 (131I), often ... Inhalation of iodine alone had been an experimental treatment for tuberculosis in France between 1830 and 1870. Widespread ... "Iodine treatment apparatus for tuberculosis, France,1830-1870". "Pioneer in X-Ray Therapy". Science. New Series. 125 (3236): 18 ...

*Iodine-125

As with other radioisotopes of iodine, iodine-125 uptake in the body (mostly to the thyroid) can be blocked with prompt ... Iodine-125 (125I) is a radioisotope of iodine which has uses in biological assays, nuclear medicine imaging and in radiation ... It is the second longest-lived radioisotope of iodine, after iodine-129. Its half-life is 59.49 days and it decays by electron ... or that absorb an iodine-containing radiopharmaceutical, the beta-emitter iodine-131 is the preferred isotope; iodine-125 is ...

*Radioactive nanoparticle

Technetium-99m, indium-111, and iodine-131 are common radioisotopes used for these purposes, with many others used as well. ... Radioisotopes - Applications in Bio-Medical Science. InTech. doi:10.5772/20719. ISBN 978-953-307-748-2. Retrieved 2017-07-11. ... as a platform for combining multiple copies of targeting vectors and effectors in order to selectively deliver radioisotopes to ...

*131 (number)

131 Vala is an inner Main belt asteroid Iodine-131, or radioiodine, is a radioisotope of iodine for medical and pharmaceutical ...

*Radioactive iodine uptake test

The patient swallows a radioisotope of iodine in the form of capsule or fluid, and the absorption (uptake) of this radiotracer ... The radioactive iodine uptake test, or RAIU test, is a type of scan used in the diagnosis of thyroid problems, particularly ... "Iodine-131 Radiotherapy for Benign Thyroid Disease". Nuclear Medicine Therapy. CRC Press: 172. ISBN 978-0-8247-2876-2. M. Sara ... It is entirely different from radioactive iodine therapy (RAI therapy), which uses much higher doses to destroy cancerous cells ...

*Index of radiation articles

... iodine-131 (radioisotope) radionuclide radioisotope thermoelectric generator (RTG) radioisotope heater units radioisotope ... radioisotope thermal generator (radiotoxic: see) ionizing radiation radium Radium, Colorado radium chloride Radium Girls Radium ...

*Iodine-129

... (129I) is a long-lived radioisotope of iodine which occurs naturally, but also is of special interest in the ... an investigation of historical iodine monitoring data Studies with natural and anthropogenic iodine isotopes: iodine ... Isotopes of iodine Iodine in biology Plus radium (element 88). While actually a sub-actinide, it immediately precedes actinium ... iodine in cooled spent nuclear fuel consists of about 5⁄6 129I and 1⁄6 the only stable iodine isotope, 127I. Because 129I is ...

*William Freer Bale

The distribution in rabbit tissues of intravenously injected iodine as shown by the radioisotope I-130, J. Pharmacol. Exp. Ther ... Med., 7(7), 491-500 (1966). R. J. McCardle, P. V. Harper, I. L. Spar, W. F. Bale, G. Andros, F. Jiminez, Studies with iodine- ... UR-637 UR Rep, 86(), 1-22 (1964). R. W. Helmkamp, M. A. Contreras, W. F. Bale, THE DETERMINATION OF TOTAL IODINE IN I-131- ... Chem., 242(10), 2343-55 (1967). R. W. Helmkamp, M. A. Contreras, W. F. Bale, I-131-labeling of proteins by the iodine ...

*Three Mile Island accident health effects

... or on radioisotopes other than iodine, krypton, and xenon. "What Happened and What Didn't in the TMI-2 Accident". American ...

*Committed dose equivalent

... injection of medical radioisotopes such as technetium-99m Some artificial radioisotopes such as iodine-131 are chemically ... or the detonation of a nuclear explosive which would release radioactive iodine. Other radioisotopes have an affinity for ... may be used to protect the thyroid from ingested radioactive iodine in the event of an accident or attack at a nuclear power ...

*Committed dose

... oxide through the skin injection of medical radioisotopes such as technetium-99m Some artificial radioisotopes such as iodine- ... or the detonation of a nuclear explosive which would release radioactive iodine. Other radioisotopes have an affinity for ... For example, iodine-131 is notable in that high doses of the isotope are sometimes less dangerous than low doses, since they ... A person who is being treated for cancer by means of an unsealed source radiotherapy method where a radioisotope is used as a ...

*Radioactive tracer

Radioisotopes of hydrogen, carbon, phosphorus, sulphur, and iodine have been used extensively to trace the path of biochemical ... 99mTc is a very versatile radioisotope, and is the most commonly used radioisotope tracer in medicine. It is easy to produce in ... According to the NRC, some of the most commonly used tracers include antimony-124, bromine-82, iodine-125, iodine-131, iridium- ... The commonly used radioisotopes have short half lives and so do not occur in nature. They are produced by nuclear reactions. ...

*Environmental radioactivity

... which suggests that seaweed is an iodine hyperaccumulator. Synthetic radioisotopes also can be detected in silt. Busby[citation ... Some of these radioisotopes are tritium, carbon-14 and phosphorus-32. Here is a list of radioisotopes formed by the action of ... This radioisotope can be released from the nuclear fuel cycle; this is the radioisotope responsible for the majority of the ... In addition some natural radioisotopes are present. A recent paper reports the levels of long-lived radioisotopes in the ...

*Noble gas compound

... clathrates of radioisotopes may provide suitable formulations for experiments requiring sources of particular types of ... similar to that seen with the neighbouring element iodine, running into the thousands and involving bonds between xenon and ...
Get exceptional Radioactive iodine therapy for feline hyperthyroidism services from highly experienced & loving pet care professionals in Fairfax, VA. Visit VCA SouthPaws Veterinary Specialists & Emergency Center today.
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... that it has virtually replaced thyroid surgery. To the nearest full day, determine how long it will take for 400 millicuries of I-131, which has a half-life of 8 days, to decay to 3.125 millicuries ...
... thyroid carcinoma (DTC) to ablate remnant thyroid cells after surgery. and 4.62?GBq. Our results revealed a significant correlation between the blood soaked up dose and blood sample activity and between the blood soaked up dose and whole body counts 24 to 48?hours after the Mupirocin IC50 administration of radioiodine. Intro Many people suffer from thyroid cancer yearly and differentiated thyroid carcinoma (DTC) is the most common type.1 Radioiodine therapy is known as an effective treatment of DTC to ablate remnant thyroid cells after surgery and to treat iodine-avid metastases.2 The different aspects of radioiodine therapy including methods, benefits, and risks can be found in the Western Association of Nuclear Medicine (EANM) recommendations and textbooks.2 Body organ absorbed estimation and dosages of rays risk is a significant problem in nuclear medication. As external rays dosimetry,3 inner rays dosimetry ...
Patients must have histologically confirmed thyroid carcinoma with the PAX8-PPARgamma translocation (translocation testing will be performed on archived tissue during the screening period).. Refractory to radioactive iodine (RAI) as defined by: the tumor does not concentrate RAI; or the patient has had RAI within the last 16 months and has had progression despite that RAI; or the last RAI treatment was ,16 months ago and the patient progressed after at least two RAI treatments; or the patient has received RAI treatments with a cumulative RAI dose of ≥22.2 GBq (600 mCi). Not a candidate for surgery or RAI therapy with curative intent.. Lesions that would be treated by external beam radiation therapy (EBRT) based on standard of care can be so treated, but then cannot be used as target lesions.. ...
Patients must have histologically confirmed thyroid carcinoma with the PAX8-PPARgamma translocation (translocation testing will be performed on archived tissue during the screening period).. Refractory to radioactive iodine (RAI) as defined by: the tumor does not concentrate RAI; or the patient has had RAI within the last 16 months and has had progression despite that RAI; or the last RAI treatment was ,16 months ago and the patient progressed after at least two RAI treatments; or the patient has received RAI treatments with a cumulative RAI dose of ≥22.2 GBq (600 mCi). Not a candidate for surgery or RAI therapy with curative intent.. Lesions that would be treated by external beam radiation therapy (EBRT) based on standard of care can be so treated, but then cannot be used as target lesions.. ...
Recombinant Mouse BAFF (carrier-free) - BAFF is a TNF cytokine member (a type II membrane protein) that acts in both a membrane-bound form and soluble cytokine form.
Recombinant Human IL-10 (mammalian expressed, carrier-free) - IL-10 was first described as a cytokine that is produced by T helper 2 (Th2) cell clones.
Just read in Laphams Quarterly, Miscellany, Winter 2017 edition: The Wests first flushable indoor toilet was designed in 1596 by John Harington, the saucy godson of Queen Elizabeth. He published his findings as The Metamorphosis of Ajax, the title a...
We have shown previously that 131I-labeled antibodies against the Thy-1.1 differentiation antigen can cure AKR/Cum (Thy-1.2+) mice bearing AKR/J (Thy-1.1+) SL2 T-cell lymphoma. In the present study we have extended these studies to the therapy of SL2 lymphoma in AKR/J mice, where 131I-anti-labeled Thy-1.1 antibodies react with both tumor and normal T-lymphocytes.. A single 25-µg bolus of 131I-labeled anti-Thy-1.1 antibody was rapidly cleared from serum by binding to spleen cells (t½ , 3 h) and only low concentrations (,2% injected dose/g) were present in tumor 24 h after infusion. Doses of 0.5-5.0 mg antibody saturated cells in the spleen but only slightly increased the proportion of antibody in tumor. In contrast, pretreatment of mice with 1.0 mg of unlabeled anti-Thy-1.1 antibody 24 h prior to 131I-labeled antibody resulted in a tumor concentration of 9.7% injected dose/g 24 h after infusion of the radiolabeled antibody. With this latter regimen, biodistribution approximated that seen in ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 (131 I) therapy, and to elucidate the probable effects of131 I therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age- and sex-matched healthy subjects were included in this study ...
I have had radioactive iodine treatment for thyoid cancer and since the treatment I have been experiencing eye flashing things seem to look like they are breathing when I look at them and I have be...
Ok... So now that we are all caught up... Lets talk about a few things so that I can clarify for a few people. 1 - I am not, nor will I be that I or my doctor forsee, be going through any kind of chemotherapy. I will be getting radioactive iodine treatment. This is not typical…
SpikenardGreenMedInfo contains 4 articles on Radioiodine 131 indicating it may contribute to Radiation-Induced Illness: Radioiodine (Iodine-131), Thyroid Cancer, and Radiation Induced Illness
Hormonal Disorders: Children contains 3 articles on - GreenMedInfo contains 4 articles on Radioiodine 131 indicating it may contribute to Radiation-Induced Illness: Radioiodine (Iodine-131), Thyroid Cancer, and Radiation Induced Illness
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Radioactive Iodine Therapy, also known as radioiodine therapy (RAI) is often used to treat hyperthyroid patients. This procedure stops the thyroid gland from producing thyroid hormones.
Stage III/IV NSCLC patients with recurrence and metastasis are often inoperable. Palliative radiotherapy and chemotherapy are recommended for these patients, but the efficacy of EBRT and chemotherapy is very limited and the survival time is often short (e.g., 6-9 months). In the present study, EBRT was combined with iodine-125 seed implantations for treating locally recurrent NSCLC with concurrent metastasis (patient Nos. 6, 13, 15, 17 and 18). The iodine-125 seed implantations were delivered, at enough radiation doses, to tumors that were difficult to reach by EBRT. We found that repeated iodine-125 seed implantations were beneficial for patients with multiple recurrences, leading to longer median survival time and progression-free survival time, and higher overall 1-year and 2-year survival rates.. For tumors ,5 cm, it is difficult to deliver a large enough dose with EBRT in order to avoid damaging adjacent normal tissues such as the lung, spinal cord, and heart [12]. It has been reported that ...
... Patient Information Introduction We hope that this leaflet will answer some of the questions you may have about radioiodine treatment. Before you have treatment with radioiodine, there are some preparations and precautions which we would like to explain to you. What is thyrotoxicosis? Thyrotoxicosis arises when the body produces too much thyroxine (T4) and triiodothyronine (T3), the thyroid hormones. These thyroid hormones are produced by the thyroid gland, which is situated in front of the windpipe in the neck. When healthy, the thyroid gland is small and cannot be easily felt. When overactive it is often enlarged and is called a goitre. Sometimes the goitre is generally enlarged and this is caused by auto antibodies (Graves Disease) and may get better over time. Another cause of enlargement is the presence of one or more swellings called adenomas. This type of goitre does not improve with time and so without treatment will always be overactive. The ...
The cyclotron is the only practical source of many carrier-free radioisotopes. The preparation and radiochemical isolation of a number of these activities, produced in the 60-inch cyclotron of Crocker Laboratory, will be presented in this paper and in subsequent papers of this series. In most cases the carrier-free radioisotopes were prepared for use in biological systems and the final preparations were in the form of isotonic saline solutions at a range of pH from 5 to 8. The present paper reports the radiochemical isolation of carrier-free Sn{sup 113} and In{sup 114} produced by bombarding cadmium with 38 Mev alpha-particles. At this energy, Sn{sup 113} and In{sup 114} are produced in a thick target by the nuclear reactions; Cd{sup 110}({alpha},n)Sn{sup 113}, Cd{sup 111}({alpha},2n)Sn{sup 113}, Cd{sup 112}({alpha},3n)Sn{sup 113}, Cd{sup 111}({alpha},p)In{sup 114}, Cd{sup 112}({alpha},pn) In{sup 114}. The shorter-lived tin and indium activities together with the possible radioisotopes of silver
Purpose: To determine whether the selective BRAF inhibitor, dabrafenib, can stimulate radioiodine uptake in BRAF V600E mutated unresectable or metastatic iodine-refractory papillary thyroid cancer (PTC). Patients and Methods: Ten patients with BRAF V600E-mutant iodine-refractory PTC were enrolled. Absence of radioiodine uptake on iodine-131 whole body scan obtained within 14 months of study entry was required. Each patient received dabrafenib (150 mg twice daily) for 25 days prior to thyrotropin alfa-stimulated iodine-131 whole body scan (4 mCi/148 MBq). Patients whose scan showed new sites of radioiodine uptake remained on dabrafenib for 17 more days, then were treated with 150 mCi (5.5 GBq) iodine-131. The primary end point of the study was the percentage of patients with new radioiodine uptake after treatment with dabrafenib. Results: Six of ten patients (60%) demonstrated new radioiodine uptake on whole body scan after treatment with dabrafenib. All six were treated with 5.5 GBq iodine-131. ...
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver radioactive tumor-killing substances to them without harming normal cel
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. This may
David asks…Does anyone know Hypheractive thyroid? whats the medication?Helen answers:Hyperthyroidism occurs when the thyroid gland makes too much thyroid
Ruth asks…Does anyone know a good, natural supplement for hyperthyroidism? I dont want to take prescription medication?Helen answers:I agree with your
Purpose: It is often assumed that animal biodistributions of novel proteins are not dependent upon the radiolabel used in their determination. In units of percent injected dose per gram of tissue (%ID/g), organ uptake results (u) may be obtained using either iodine or metal as radioactive labels. Iodination is preferred as it is a one-step process whereas metal labeling requires two chemical procedures and therefore more protein material. It is important to test whether the radioactive tag leads to variation in the uptake value. Methods: Uptakes of 3antibodies to Carcinoembryonic Antigen (CEA) were evaluated in a nude mouse model bearing 150 to 300 mg LS174T human colon cancer xenografts. Antibodies included diabody (56 kDa), minibody (80kDa) and intact M5A (150 kDa) anti-CEA cognates. Both radioiodine and indium-111 labels were used with uptakes evaluated at 7 time(t) points out to 96 h. Ratios (R) of u(iodine-label)/u(indium-label) were determined for liver, spleen, kidneys, lung and tumor. ...
A study was carried out to determine the suitability of utilizing a 4 to 5 hr interval from administration of Iodine-123 to imaging and uptake measurement as a replacement for the 24-hr standard originally established with Iodine-131. In 55 patients who underwent scintigraphy at 4 and 24 hr, there was no discrepancy between paired images. In 55 patients who had uptake measured at 4 and 24 hr and in 191 patients who had uptake measured at 5 and 24 hr, the early measurements proved equal or better discriminants of euthyroid from hyperthyroid patients. In our institutions, these findings and the logistical advantages of completing the exam in 4-5 hr led us to abandon the 24-hr study in the majority of patients. ...
Relative to the incident cases of differentiated thyroid cancer, the use of imaging after primary treatment has grown dramatically from 1998 to 2011. This substantial increase in imaging after primary treatment is associated with more diagnoses of recurrence, but no significant improvement in disease specific survival, except with use of radioiodine scans. This finding suggests that imaging after primary treatment could lead to detection of more recurrence and subsequent treatment of recurrence, but in many cases without a beneficial effect on disease specific survival.. In our study, use of neck ultrasound was associated with a significant increase in the likelihood of recurrence treatment with surgery and with radioactive iodine treatment. However, neck ultrasound was not associated with improved disease specific survival. It is well known that most thyroid cancer recurrence is regional (that is, appearing in metastases to cervical lymph nodes).17 18 Neck ultrasound is the optimal imaging ...
If you receive a thyroid cancer diagnosis, youll most likely hear that your treatment options involve chemotherapy, radiation and possibly surgery - the familiar "cut, burn and poison." As you know if you read this newsletter, I strongly prefer natural and alternative methods of treating cancer. Particularly for slow-growing and most-likely-harmless papillary thyroid cancer, I would try alternatives first.. The treatment a conventional doctor recommends will depend on the type and stage of your thyroid cancer.. Doctors may opt to remove all of the gland or just a portion with surgery. If you have the entire gland removed, you have less chance of any recurring cancers.. But in either case-youll have to take hormone medications for life to supply the missing hormone your thyroid would normally produce.. If doctors recommend radioactive iodine treatments, you may experience nausea, pain and an altered sense of taste or smell.. If youre wondering about natural treatments to help with thyroid ...
At first glance, the concept of using radionuclide-labeled monoclonal antibodies to target radioactivity to tumor sites for the detection and possible treatment of malignancies appears quite appealing in terms of its rationale and simplicity. However, as is apparent in Dr. Divgis comprehensive review of the many clinical studies that have been performed to test this concept, there are a number of complexities that require further study and resolution so that this approach can be optimally and more widely applied in clinical medicine. Although Dr. Divgi touches on many of these issues, some points are worthy of emphasis and further discussion. 1
Unless specified otherwise, MP Biomedicals products are for laboratory research use only, not for human or clinical use. For more information, please contact our customer service department ...
Lenvima, a kinase inhibitor, blocks certain proteins that help cancer cells grow and divide Read More.... This past week the U.S. Food and Drug Administration (FDA) approved Eisais Lenvima (lenvatinib), an oral multiple receptor tyrosine kinase (RTK) inhibitor for the treatment of progressive, differentiated thyroid cancer (DTC) in patients whose disease progressed despite receiving radioactive iodine therapy. DTC is a cancerous growth of the thyroid gland in the neck that helps to regulate the bodys metabolism. Study results showed Lenvima-treated participants lived a median of 18.3 months without their disease progressing (progression-free survival), compared to a median of 3.6 months for participants who received a placebo. Lenvima was approved under the FDAs priority review program.. ...
Effect of 1.11/1.85 versus 3.7 GBq iodine-131 under rhTSH stimulation on thyroid remnant ablation rate according to diagnostic scans. CI, confidence interval; r
Can you live without a thyroid? Understanding your options after radioactive iodine therapy or thyroidectomy can help you make the best treatment decision.
Principal Investigator:ENDO Keigo, Project Period (FY):1995 - 1996, Research Category:Grant-in-Aid for Scientific Research (B), Section:一般, Research Field:Radiation science
Just wondering if anyone might be able to recommend some books, publications, etc., on how to deal with cancer on an emotional level. I went for my yearly gynological exam Aug 1 to discover I had a lump on my neck - how I missed it Ill never know and I could kick myself for it. Had a sonogram done and then called our family surgeon - this dr. took care of my mom when she had her masectomy in 1987. He did a needle biopsy and when he called the next day I knew it wasnt good. He said he wanted to do a complete thyroidectomy - not necessarily cancer, but just to be sure (I should have known he was just saying that so I wouldnt freak out). The next week I had surgery to remove it - and it was cancer - papillary and it had not spread. Not sure what stage - suppose I should ask that. Waited about a month for my blood levels to regulate and then had 2 radioactive iodine treatments - of which the hardest part was being away from my kids. From what that showed, nothing had spread. Got my meds pretty ...
Efficacy of Fixed High Dose Radioiodine Therapy for Hyperthyroidism - a 14 year Experience: A focus on Influence of Pre-treatment Factors on Outcomes. Khalid, Y.; Barton, D. M.; Baskar, V.; Kumar, H; Jones, P.; West, T. E. T.; Buch, H. N. // British Journal of Medical Practitioners;2011, Vol. 4 Issue 3, p7 Background: Radioiodine therapy (RAI) is commonly used as a definitive treatment for hyperthyroidism. However there is no agreement on the regime or the dose of RAI used and success rate is quite variable. In addition, the literature on the factors governing the success of the initial dose is... ...
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Percentage of initial radioiodine retained in dental amalgam samples after multiple normal saline (NS) washes, with non-zero asymptotes indicating residual iodi
Feline Hyperthyroid Treatment Center, Shoreline, Tacoma Washington. www.felinehtc.com. Offering the safest, most reliable treatment for Feline Hyperthyroidism . Radioiodine therapy is the safest and most effective therapy available for cats.
Feline Hyperthyroid Treatment Center, Shoreline, Tacoma Washington. www.felinehtc.com. Offering the safest, most reliable treatment for Feline Hyperthyroidism . Radioiodine therapy is the safest and most effective therapy available for cats.
Unfortunately, doctors do not know what the best treatment is for each individual patient. There is no correct answer. Options include surgery, radiation therapy (external beam therapy, seed implantation), and active surveillance (referred to previously as watchful waiting). All of these treatments are complex and require many considerations including side effects from the treatment (impotence, incontinence), success rates, and ultimately patients wishes. It is strongly recommended that patients get a second opinion and have a competent and skilled medical advisor other than the treating physician to help them make the best decision ...
A patient is given a 5 mCi dose of 131I. Estimate the activity of her thyroid after 4 days. (Assume that all remaining 131I has been absorbed by her thyroid. Radioactive half-life of 131I is 8 days and it has a biological half-life of 138 days. ...
With the development of ZYTO biocommunication, it is easy to identify your body’s biological preference for things relating to your health
Many people with Graves Disease have received the radioactive iodine uptake test. This test involves the person swallowing a small dosage of radioactive iodine. The thyroid gland in turn will absorb the radioactive iodine, and this is then evaluated after six hours, and then once again after 24 hours.. Many endocrinologists use the radioactive iodine uptake test to come up with their diagnosis of Graves Disease. However, its important to understand that this test does not conclude that someone has this autoimmune hyperthyroid condition. If the results of the uptake test are high then this shows that the thyroid gland is secreting an excessive amount of thyroid hormone, and in many instances the person with a high uptake test will have Graves Disease. This test can also determine the presence of hot and cold nodules, which can give the doctor an idea as to whether they are benign or malignant.. But while the radioactive iodine uptake test can be helpful, the only surefire method to confirm ...
Many people with Graves Disease have received the radioactive iodine uptake test. This test involves the person swallowing a small dosage of radioactive iodine. The thyroid gland in turn will absorb the radioactive iodine, and this is then evaluated after six hours, and then once again after 24 hours.. Many endocrinologists use the radioactive iodine uptake test to come up with their diagnosis of Graves Disease. However, its important to understand that this test does not conclude that someone has this autoimmune hyperthyroid condition. If the results of the uptake test are high then this shows that the thyroid gland is secreting an excessive amount of thyroid hormone, and in many instances the person with a high uptake test will have Graves Disease. This test can also determine the presence of hot and cold nodules, which can give the doctor an idea as to whether they are benign or malignant.. But while the radioactive iodine uptake test can be helpful, the only surefire method to confirm ...
I just had my thyroid surgery. When can I have my radioactive iodine treatment?. In order for the radioactive iodine treatment to be effective and destroy any remaining thyroid tissue, the levels of TSH, secreted by the pituitary gland must rise to elevated levels. TSH, also known as thyroid stimulating hormone, stimulates the thyroid cells to take up the radioactive iodine. For the levels of TSH to rise, the levels of thyroid hormone must have dropped to very low levels. As thyroid hormone has a long half life, it takes many weeks for levels to drop and TSH levels to rise. Accordingly, the earliest time interval that radioactive iodine can be effectively administered is 4 weeks after surgery (complete removal of the thyroid) if the patients has stopped taking all thyroid hormone supplements. To avoid prolonged hypothyroidism, some patients will use Thyrogen. Others will take Cytomel (T3), which must be stopped ~ 14 days prior to the radioactive iodine treatment. Hence, although many patients ...
In a comprehensive review and meta-analysis of the currently available literature covering 16,502 patients with thyroid cancers, the relative risk for the development of leukemia was increased 2.5-fold in patients treated with radioiodine.22 In line with this, thyroid cancer was also identified as the second most common primary neoplasm arising in patients who developed tAML following treatment for solid cancers.7 Still, data on patients with therapy-related myeloid neoplasms following radioiodine treatment have been scarce so far, comprising case reports on a total of only 33 patients.. Our analysis shows that the great majority of patients developing therapy-related myeloid neoplasms following radioiodine treatment already present with AML or high-risk MDS as reflected by blast count, karyotype, IPSS or rapid disease progression. These patients do, therefore, share major biological characteristics with patients with tMDS/tAML following chemotherapy, radiation or radiochemotherapy, as indicated ...
mild illness prefer to be treated with medication.Also with this method begins when a problem occurs in teenagers and children.In other cases it is better to carry out the treatment of hyperthyroidism with radioactive iodine.The preparation has the form of capsules or an aqueous solution.. By the way, in Europe, doctors generally have more confidence in it various antithyroid drugs than treatment with radioactive iodine.But in the US, preference is given exactly as the radioiodine therapy more effective.Of course, after that you need to undergo a program of rehabilitation, but then the medication also requires further recovery.. first input of radioisotopes of iodine carried out in 1941 in the United States.And since 1960 the method was used in medicine already widely.Over the past period we were convinced of its usefulness, reliability and security.Yes, and the treatment of radioactive iodine price became more affordable.In some clinics in America and Europe in small doses of iodine treatment ...
In heart failure secondary to chronic mechanical overload, cardiac sympathetic neurons demonstrate depressed catecholamine synthetic and transport function. To assess the potential of sympathetic neuronal imaging for detection of depressed transport function, serial scintigrams were acquired after the intravenous administration of metaiodobenzylguanidine [131I] to 13 normal dogs, 3 autotransplanted (denervated) dogs, 5 dogs with left ventricular failure, and 5 dogs with compensated left ventricular hypertrophy due to a surgical arteriovenous shunt. Nine dogs were killed at 14 hours postinjection for determination of metaiodobenzylguanidine [131I] and endogenous norepinephrine content in left atrium, left ventricle, liver, and spleen. By 4 hours postinjection, autotransplanted dogs had a 39% reduction in mean left ventricular tracer accumulation, reflecting an absent intraneuronal tracer pool. Failure dogs demonstrated an accelerated early mean left ventricular tracer efflux rate (26.0%/hour ...
ANN ARBOR, Mich. - Where thyroid cancer patients go for care plays a large role in whether they receive radioactive iodine treatment, a new study from the University of Michigan Comprehensive Cancer Center finds.. While the size and severity of the tumor also played a role in treatment, researchers found unexplained hospital factors had a significant impact on radioactive iodine use.. "What hospital you go to makes a difference in use of radioactive iodine. It doesnt just matter what the tumor looks like, but where you go for care," says lead study author Megan Haymart, M.D., assistant professor of internal medicine at the U-M Medical School.. Results of the study appear in the Aug. 17 issue of the Journal of the American Medical Association.. Thyroid cancer is currently one of the 10 most common cancers in the United States and is expected to become even more common in the next decade as more small, early stage cancers are uncovered.. Radioactive iodine following surgery to remove the thyroid ...
If detected in timely manner, hyperthyroidism may be kept under control with medication. The purpose of the medication is to reduce the production of thyroid hormones. Methimazole drugs are typically prescribed to cats with hyperthyroidism. Methimazole can be administered twice per day. In rare cases, there may be side effects such as lack of appetite, vomiting, sleepiness, scratching or bleeding. If you notice any of these side effects talk to your vet, as the drug might have to be discontinued. However, the medication cannot fully treat the condition; surgery or radioiodine therapy is necessary. Surgery, also known as thyroidectomy will treat the condition; thyroid tissues are removed and the hormonal balance is re-established. In some cases, both thyroid glands will be removed entirely to prevent the hyperfunction. The cat must get calcium supplements post surgery. Radioiodine therapy is also successful in treating the condition. The radioactive iodine therapy consists of radiations that will ...
Radioiodine has been used in nuclear medicine for the treatment of thyroid diseases such as Thyroid Cancer and Thyrotoxicosis for many years. The treatment renders the patient radioactive. To minimize the dose to the patients relatives and the general public, restric-tions are imposed on the behaviour of the patient. This project presents the person dose equivalents actually received by family members of radioiodine patients following such restrictions. The family members wore hospital ID-bands on left and right wrists for up to four weeks. Each ID-band contained two LiF: Mg, Ti Thermo Luminescence Dosimeters (TLD) calibrated to measure air kerma. The TLDs were analysed and a total person dose equivalent received by the relative was calculated from the measured air kerma values. The results were compared to the dose constraints imposed by The Swedish Radiation Protection Authority (SSI FS 2000:3) in order to confirm that the new set of restrictions used at Karolinska University Hospital ...
Ten years have now elapsed since the first patient with carcinoma of the thyroid was treated with radioactive iodine.1 More than 250 thyroid carcinoma patients have been treated since then with radioactive iodine, I131.2 Review of the literature and our experience in treating 24 such patients have indicated certain criteria to be of definite value in the selection of patients for I131 therapy. Lack of regard for these criteria has, in our hands, led to wasteful use of I131 and rise of false hopes in the thyroid cancer patient. It is the purpose of this discussion, therefore, to review these ...
20 ng/ml) serum Tg levels and negative Anti TgAb. In 75 patients (8.4% of patients or 63% of the Tg+ve subgroup), elevated Tg levels correlated well with positive 131I imaging. In 13 patients with positive correlation Tg/131I WBS, WBS revealed pulmonary (12 pts) or bone (1 pt) metastases, with no uptake in the cervical region. Moreover, 45 patients (5% of all patients or 37.5% of the Tg+ve group) presented discordant elevated Tg levels and negative Anti TgAb but negative WBS imaging. Using the same immune-radiometric method, with optimal sensitivity for Tg and without reported Hook effect for Anti TgAb, we found in 9% of patients the presence of strong positive Anti Tg, interfering with the Tg assay and underestimating serum Tg levels. From 890 patients sera, in 79 % Anti TgAb were < 35 mUI/ml (negative value), 8 % were equivocal (35-65%) and 12 % were strongly positive ( >65 mUI/ml). Conclusions: Detectable or elevated Tg concentrations most often correlate with 131I uptake, allowing ...
Almost one third of all new thyroid cancers diagnosed are in young adults ages 20 to 40 and thyroid carcinomas represent approximately 6-12% of all malignancies diagnosed in this age group. Thyroid carcinomas are 5 times more common in females than males among 20 to 40 year olds, accounting for 4% of all cancers in women. Thyroid cancer is also one of the most common malignancies to occur during pregnancy and therefore it is imperative to assess the treatment and management of such cases individually with possible delay in surgery and radioactive iodine therapy. Overall survival rates are exceptional with 5-year survival rates for individuals diagnosed before the age of 40 above 99%. Future research will hopefully shed light to understanding the long-term and potentially adverse effects of different thyroid treatment therapies as well as their effects on reproduction, which may impact the survivorship of this community.. Source: Ying A, Huh W, Bottomley S, et al. Thyroid Cancer in Young Adults. ...
Institute of Nuclear Medicine, Lorma Medical Center now offers other necessary laboratory tests and treatments, like RIA, thyroid uptake, and radioactive iodine therapy, in addition to body scans.. * FT3, FT4. RIA stands for Radioimmunoassay. This is a laboratory test used to measure the concentration of biological substances such as enzymes, hormones, steroids, and vitamins in blood, urine, saliva, or other body fluids. RIA is an important research tool and has been used in hospitals to help diagnose diabetes, thyroid disorders, hypertension, reproductive problems, and other disorders.. Other Procedures. ...
Treatments for thyroid cancer include surgery, radioactive iodine therapy and hormonal therapy. Learn about treatment plans and options for thyroid cancer.
Radioactive iodine- Radioiodine is now more widely used in the UK, as has previously happened elsewhere, although it is contraindicated in pregnancy and while breast-feeding. Iodine-131 in an empirical dose (usually 200-500 MBq), accumulates in the thyroid and destroys the gland by local radiation - though it takes several months to be fully effective. Strict radiation safety rules apply in the UK and may be inconvenient or disconcerting for some patients. Patients must be rendered euthyroid before treatment though they have to stop antithyroid drugs at least 4 days before radioiodine, and not recommence until 3 days after radioiodine (many patients who are well controlled before radioactive iodine do not need to restart at all). Risk of carcinogenesis has been long debated, but it is now clear that overall cancer incidence and mortality are not increased after radioactive iodine (and indeed are significantly reduced in some studies) but the risk of thyroid cancer is significantly increased ...
Radiation therapy is commonly used to treat thyroid cancer. Learn about radioactive iodine therapy, or RAI, and external beam radiation.
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
In the past decade there is a growing "Go Green" movement and of course we are all about going "green" but during and after thyroid cancer surgery and treatment might not be the time. If you live alone, paper plates and plastic cups, bowls and utensils are essential. You wont be in the mood to do the dishes and looking at dirty dishes will only make you moody! ...
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I have to say, I think the program you have me on is working great. I am feeling better than I can remember in many, many years. Some of it is hard to put into words, it is just an overall feeling of better health. I really appreciate your help.". "It was out of pure desperation I ended up in Dr. Wetzel office. I had been going through two years of serious medical issues. Diagnosed with papillary thyroid cancer, had two major surgeries, two radioactive iodine treatments, up and down on medications and I felt absolutely horrible. My doctors were great at what they did but rarely took a whole body approach. My TSH was normal but I felt very hypothyroid. Achy, fatigued, muscle spasms, depressed, sad, lethargic, couldnt concentrate, weight gain, etc. I was miserable!". "Dr. Wetzel was so sweet. She listened, she looked me in eye, and she genuinely cared about my situation. She didnt ignore one symptom, not one. After a few test and assessments, she started me on a regimen and within 3 weeks I ...
I have to say, I think the program you have me on is working great. I am feeling better than I can remember in many, many years. Some of it is hard to put into words, it is just an overall feeling of better health. I really appreciate your help.". "It was out of pure desperation I ended up in Dr. Wetzel office. I had been going through two years of serious medical issues. Diagnosed with papillary thyroid cancer, had two major surgeries, two radioactive iodine treatments, up and down on medications and I felt absolutely horrible. My doctors were great at what they did but rarely took a whole body approach. My TSH was normal but I felt very hypothyroid. Achy, fatigued, muscle spasms, depressed, sad, lethargic, couldnt concentrate, weight gain, etc. I was miserable!". "Dr. Wetzel was so sweet. She listened, she looked me in eye, and she genuinely cared about my situation. She didnt ignore one symptom, not one. After a few test and assessments, she started me on a regimen and within 3 weeks I ...
Materials and methods of making low-sintering-temperature glass waste forms that sequester radioactive iodine in a strong and durable structure. First, the iodine is captured by an adsorbant, which forms an iodine-loaded material, e.g., AgI, AgI-zeolite, AgI-mordenite, Ag-silica aerogel, ZnI.sub.2, CuI, or Bi.sub.5O.sub.7I. Next, particles of the iodine-loaded material are mixed with powdered frits of low-sintering-temperature glasses (comprising various oxides of Si, B, Bi, Pb, and Zn), and then sintered at a relatively low temperature, ranging from 425.degree. C. to 550.degree. C. The sintering converts the mixed powders into a solid block of a glassy waste form, having low iodine leaching rates. The vitrified glassy waste form can contain as much as 60 wt % AgI. A preferred glass, having a sintering temperature of 500.degree. C. (below the silver iodide sublimation temperature of 500.degree. C.) was identified that contains oxides of boron, bismuth,
Healthcare experts say that radioactive iodine can be safely administered after a thyroidectomy because only leftover thyroid cells will absorb the isotope.
According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) is impaired in many lung diseases and low lung uptake of 123I-MIBG suggests endothelial dysfunction of the pulmonary artery. 123I-MIBG scintigraphy in patients with pulmonary hypertension (PH) has not yet been clinically evaluated. We hypothesized that the lung uptake of 123I-MIBG is reduced in patients with PH and differs among PH subtypes. The purpose of the present study was to analyze the lung uptake of 123I-MIBG in patients with PH and compare it with the data obtained by echocardiography or right heart catheterization ...
I did not have a high Tg post-surgery. But I thought that it can take a couple of months for the Tg to get out of your body. Because it circulates in the blood, the time frame will vary from person to person. You are not even 2 months post TT so I would expect that your Tg will be lower. Although the Tg level of 221 is still high. The most important Tg level will be after your RAI treatment (and RAI can take awhile to work, even up to 1-year until you see the true Tg level). The RAI absorbs thyroid cells only and tg is only made from thyroid cells or thyroid cancer. So there is a very good possibility that your have additional lymph nodes that could be thyroid cancer or other tumors. Also, it sounds like you have only had the tracer dose of RAI.....the full dose (178 mci) may show additional areas. Sometimes the tracer is not enough and additional sites will show up only after you have had the full RAI dose. I have recurrent thyroid cancer (follicular variant of papillary). My Tg went up to 150 ...
Radioiodinated bleomycin is a useful imaging agent for body tissues. Its production by iodination of bleomycin with radioactive iodide ions in the presence of an oxidizing agent is described.
Bei der Brachytherapie werden spezielle Hülsen, Schläuche, Stifte (Seeds) oder Nadeln z. B. direkt in die Prostata oder Gebärmutter implantiert. Die Implantate geben radioaktive Strahlen ab.
Kinuya S, Yoneyama T, Michigishi T.Airway complication occurring during radioiodine treatment for Graves disease. Annals of Nuclear Medicine 21: 367-369, No. 6, Aug 2007 - JapanGoogle Scholar ...
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The only disappointing news I received (besides the fact that I continue to have thyroid cancer, will have a thyroidectomy, and be on a thyroid replacement hormone for the rest of my life) is that during RAI treatment I cannot be around baby, or anyone, for two weeks. Two weeks of partial confinement- no hugs from family, no comforting my crying baby, no snuggles from Josh. It is going to be lonesome and sad. But it is only going to be for two weeks, and Im telling myself I can do anything for two weeks ...
... ,125 iodine seed implantation is an effective technique for the treatment of malignant tumors, which belongs to a kind of brachytherapy. The
Researchers at the National Institutes of Health (NIH), Bethesda, MD, have taken the first steps to determine if a protein, called Programmed Death Ligand 1 (PD-L1), can help to predict which thyroid cancer patients will most likely have a recurrence of the disease. Study findings were presented at the 2013 Clinical Congress of the American College of Surgeons.
Home testing and Human carcinogen - Iodine-131, diagnostic tests, self assessment, and other tools and products in relation to Human carcinogen - Iodine-131.
Anti-Myogenin antibody [F5D] (ab1835) has been cited in 29 publications. References for Human, Mouse, Rat, Cow, Cat in ICC, ICC/IF, IF, IHC, IHC-Fr, IHC-P, WB
Liver Failure: Drug Induced contains 2 articles on - GreenMedInfo contains 4 articles on Radioiodine 131 indicating it may contribute to Radiation-Induced Illness: Radioiodine (Iodine-131), Thyroid Cancer, and Radiation Induced Illness
iodine-131 definition: (medication) The radioactive isotope of iodine, 13153I, having a half-life of 8 times; made use of as a medical tracer; heavy radioactive isotope of iodine with a half-life of 8…
The abbreviation ul (for uniformly labeled) may be used without expansion in parentheses: [14C]glucose (ul) Similarly, terms such as carrier-free, no carrier added, and carrier added may be used. In general medical publications, these terms should be explained at first mention, since not all readers will be familiar with them. |
The abbreviation ul (for uniformly labeled) may be used without expansion in parentheses: [14C]glucose (ul) Similarly, terms such as carrier-free, no carrier added, and carrier added may be used. In general medical publications, these terms should be explained at first mention, since not all readers will be familiar with them. |
Lab Findings: TSH 0.05, T4: 12.5 . A thyroid scan and uptake scan were (Image 1): 2 hr uptake: 20% (Normal = 5-15%), 24 hr uptake: 40% (Normal = 15-35%) . The patient was then treated with 10 mCi I-131. The patient returned 4 months later with significant improvement of symptoms, TSH 2.5, T4 11, Thyroid uptake and scan (image 2): 2 hr uptake: 8%, 24 hr uptake: 20%.. What is the most likely diagnosis for the finding in Image 1?. ...
August 29th 2008 - This is one of the biggest atomic scandals in Europe EVER! ONE WEEK after radioactive Iodine 131 was released into the environment from the Belgian factory in Fleurus [map] officals informed the people living in the City Fleurus about the accident. Source This is the website of the scandal factory which…
BLU products are packaged in a lead-free container ("pig"). NEG products are packaged in a lead-lined container (plastic pig containing a layer of lead).. ...
Aakland Iodine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Aakland Iodine is available on the Drugs.com website.
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i-131 treatment - MedHelps i-131 treatment Center for Information, Symptoms, Resources, Treatments and Tools for i-131 treatment. Find i-131 treatment information, treatments for i-131 treatment and i-131 treatment symptoms.
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Looking for online definition of radioactive iodine uptake in the Medical Dictionary? radioactive iodine uptake explanation free. What is radioactive iodine uptake? Meaning of radioactive iodine uptake medical term. What does radioactive iodine uptake mean?
Objective: To assess predictors of well-differentiated thyroid cancer (WDTC) persistence/recurrence. Design: This was a retrospective chart review of thyroid carcinoma patients seen 1979-2007 in a Boston, Massachusetts-area multispecialty group. Of 1,025 patients, 431 met eligibility criteria. Cox proportional hazards models were used to assess predictors (gender, age, ethnicity, tumor size, surgical histology) of WDTC persistence/recurrence (elevated thyroglobulin levels with negative thyroglobulin-antibodies; or positive imaging). Local extension of disease and lymph node involvement could not be assessed. Results: Mean age at initial surgery (n = 431, 74% women, 79% Caucasian) was 45.8 \(\pm\) 13.5(SD) years. Mean tumor (papillary, 91%; follicular, 5%; Hurthle cell, 2%; \(\ge\)1 type, 2%) size was 2.5 \(\pm\) 1.6(SD) cm. Most tumors were unifocal (57%) and \(\ge\)1 cm (89%). Over 2,600 person-years of follow-up, persistence/recurrence occurred in 52 patients (12%) 4.3 years (median; range ...
Genes encoding for intracellular enzymes or transmembrane proteins are suitable as reporters, but may differ in terms of applicability for cardiac imaging. The aim of this study was to compare the hum
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy with the highest mortality although with appropriate treatment has a good long-term prognosis and cure rate. Over the last 30 years there is a worldwide trend showing an increasing incidence of thyroid cancer. In DTC patients, total thyroidectomy has been for many decades routinely followed by the administration of radioiodine (131I) activity to destroy remnant thyroid tissue. Several reasons are in favour to routine ablation of postoperative thyroid remnants. The combination of both surgery and radioiodine has proven as a safe and effective treatment, resulting in improved life expectation and reduced recurrence rate for DTC patients. Recently, however, 131I ablation is not uniformly recommended for cancers smaller than 10 mm, and its use is debated for papillary tumours with diameter between 10 and 20 mm. Indeed, the decision about subsequent 131I thyroid remnant ablation is recommended as individualized and ...
Page contains details about 125I-labeled antibody against intercellular adhesion molecule-1-coated green fluorescent polystyrene nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Six patients experienced voice change immediately after RFA. Voice change was recovered in 5 patients. One patient without recovery was treated with vocal cord medialization. All 6 patients with voice change had tumors in the level VI. There were no other significant complications, and most of the patients tolerated the RFA procedure well. Although some patients reported a burning sensation, pain, or both, the symptoms were relieved by reducing the RF power or stopping the ablation for several seconds.. In conclusion, RFA can be effective in treating loco-regional, recurrent, and well-differentiated thyroid carcinoma in patients at high surgical risk.. ...
TY - JOUR. T1 - Recombinant human thyrotropin before 131I therapy in patients with nodular goitre. T2 - A meta-analysis of randomized controlled trials. AU - Lee, Yen Ying. AU - Tam, Ka-Wai. AU - Lin, You Meei. AU - Leu, Wuan Jin. AU - Chang, Jui Chia. AU - Hsiao, Chi Lien. AU - Hsu, Meng Ting. AU - Hsieh, An-Tsz. PY - 2015/11/1. Y1 - 2015/11/1. N2 - Background Recombinant human thyrotropin (rhTSH) can be used to enhance radioiodine therapy for shrinking multinodular goitre. The aim of this meta-analysis was to compare the effectiveness of rhTSH pretreatment and radioiodine therapy with that of radioiodine alone for treating benign nodular goitre. Methods The PubMed, EMBASE, Cochrane Library, Scopus and ClinicalTrials.gov databases were searched to identify studies published before September 2014. A meta-analysis was performed to calculate the pooled effect size using random-effects models. The primary outcome was the reduction in thyroid volume. Secondary outcomes included thyroid function, ...
The primary goals of treatment for hyperthyroidism are to eliminate excess thyroid hormone and minimize the long-term consequences.9 Treatments include radio-active iodine, antithyroid medications (propylthiouracil [PTU], methimazole [MMI]), and surgery.2,8-10 Beta-blockers are sometimes added to provide symptomatic relief.9,13,15. Radioactive Iodine Therapy (RIT): The usual dose for RIT ranges from 5 to 15 mCi of 131I. In general, higher dosages are required for patients who have large goiters or low radioiodine uptake, or who have been pretreated with antithyroid drugs.15,16. Because the thyroid needs iodine to produce hormones, the radioiodine goes into the thyroid cells and, over time, overactive thyroid cells are destroyed. The thyroid gland shrinks, and in several weeks to months, hyperthyroid symptoms gradually diminish.16 RIT may increase the risk of new or worsened symptoms of Graves ophthalmopathy. This adverse effect is usually mild and temporary, but the therapy may not be utilized ...
Introduction: We report an unusual case of adenocarcinoma of lung metachronous with stage IVA papillary thyroid carcinoma. The two tumors are morphologically similar; and the later presence of lung mass could clinically masquerade as metastatic thyroid carcinoma. We discuss the challenges in clinical, imaging and pathologic diagnosis. Case Report: A 64-year-old non-smoking female had a thyroidectomy and neck lymph node dissection for a stage IVA tumor with pathologic findings of one 2 mm microcarcinoma of left thyroid and six positive cervical lymph nodes. The post-surgical I131 whole body scan was negative and thyroglobulin is suppressed and stable (<1 ng/ml). One year later, she developed a ground glass and part-solid mass in the superior segment of left lower lobe of lung. The mass slowly grew increasing in size from 2.4 cm to 3.3 cm over 3 years. Biopsy of the lung lesion reveals morphologic features of nuclear inclusions and papillae similar to the previously diagnosed thyroid carcinoma. However,
TY - JOUR. T1 - Congenital hypothyroidism due to a new deletion in the sodium/iodide symporter protein. AU - Tonacchera, Massimo. AU - Agretti, Patrizia. AU - De Marco, Giuseppina. AU - Elisei, Rossella. AU - Perri, Anna. AU - Ambrogini, Elena. AU - De Servi, Melissa. AU - Ceccarelli, Claudia. AU - Viacava, Paolo. AU - Refetoff, Samuel. AU - Panunzi, Claudio. AU - Bitti, M. L M. AU - Vitti, Paolo. AU - Chiovato, Luca. AU - Pinchera, Aldo. PY - 2003/10/1. Y1 - 2003/10/1. N2 - OBJECTIVE: Iodide transport defect (ITD) is a rare disorder characterised by an inability of the thyroid to maintain an iodide gradient across the basolateral membrane of thyroid follicular cells, that often results in congenital hypothyroidism. When present the defect is also found in the salivary glands and gastric mucosa and it has been shown to arise from abnormalities of the sodium/iodide symporter (NIS). PATIENT: We describe a woman with hypothyroidism identified at the 3rd month of life. The diagnosis of ITD was ...

Radioactive Waste Management/Spent Nuclear Fuel - Wikibooks, open books for an open worldRadioactive Waste Management/Spent Nuclear Fuel - Wikibooks, open books for an open world

But a considerable number are medium to long-lived radioisotopes such as 90Sr, 137Cs, 99Tc and 129I. Research has been ... Some of the radioactive elements in spent fuel have short half-lives (for example, iodine-131 has an 8-day half-life) and ... Iodine,I, Xenon,Xe, Caesium,Cs, Barium,Ba, Lanthanum,La, Cerium,Ce, Nd). Many of the fission products are either non- ...
more infohttps://en.wikibooks.org/wiki/Radioactive_Waste_Management/Spent_Nuclear_Fuel

Iodine Radioisotopes - MeSH - NCBIIodine Radioisotopes - MeSH - NCBI

Radioisotopes, Iodine. All MeSH CategoriesChemicals and Drugs CategoryInorganic ChemicalsElementsHalogensIodineIodine Isotopes ... Iodine Radioisotopes. All MeSH CategoriesChemicals and Drugs CategoryInorganic ChemicalsIsotopesIodine IsotopesIodine ... All MeSH CategoriesChemicals and Drugs CategoryInorganic ChemicalsIsotopesRadioisotopesIodine Radioisotopes ... Iodine Radioisotopes. Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights ...
more infohttps://www.ncbi.nlm.nih.gov/mesh?Db=mesh&Cmd=DetailsSearch&Term=%22Iodine+Radioisotopes%22%5BMeSH+Terms%5D

The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine | Springer for Research & DevelopmentThe Radiopharmaceutical Chemistry of the Radioisotopes of Iodine | Springer for Research & Development

Radioisotopes of iodine have been incorporated into a wide variety of radiopharmaceuticals ranging from small, low molecular ... Radioisotopes of iodine have been incorporated into a wide variety of radiopharmaceuticals ranging from small, low molecular ... Because of the routine availability of radioisotopes of iodine with different nuclear decay properties, radioiodination is an ... Vaidyanathan G., Zalutsky M.R. (2019) The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine. In: Lewis J., Windhorst ...
more infohttps://rd.springer.com/chapter/10.1007%2F978-3-319-98947-1_22

Dating of Long-lived Iodine Radioisotope (129I) in Pore Waters from Shallow Gas Hydrate Deposits in the Okhotsk Sea and Japan...Dating of Long-lived Iodine Radioisotope (129I) in Pore Waters from Shallow Gas Hydrate Deposits in the Okhotsk Sea and Japan...

Dating of Long-lived Iodine Radioisotope (129I) in Pore Waters from Shallow Gas Hydrate Deposits in the Okhotsk Sea and Japan ...
more infohttps://gbank.gsj.jp/geolis/geolis_link/201740501/en

Iodine-Rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor in Vivo.  - PubMed - NCBIIodine-Rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor in Vivo. - PubMed - NCBI

Iodine-Rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor in Vivo.. Cao J, Wei Y, ... Here, we report that iodine-rich polymersomes (I-PS) enable versatile single-photon emission computed tomography (SPECT)/ ... I-PS emerges as a robust and versatile platform for dual-modal imaging and targeted radioisotope therapy. ... computed tomography (CT) dual-modal imaging and potent radioisotope therapy for breast cancer in vivo. Interestingly, I-PS ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/31062589

p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.

Iodine Radioisotopes. Kinetics. Platelet Aggregation / drug effects. Radioligand Assay. Receptors, Adrenergic, alpha / ... 0/Adrenergic alpha-Agonists; 0/Iodine Radioisotopes; 0/Receptors, Adrenergic, alpha; 108294-53-7/4-iodoclonidine; 146-48-5/ ...
more infohttp://www.biomedsearch.com/nih/p-125Iiodoclonidine-partial-agonist-at/1974694.html

Nuke Pro: Lies Of Nuclear -- Nuke Propaganda Debunked, There IS NOT Any Significant Natural Radio-Isotopes Like Iodine 131 and...Nuke Pro: Lies Of Nuclear -- Nuke Propaganda Debunked, There IS NOT Any Significant Natural Radio-Isotopes Like Iodine 131 and...

Lies Of Nuclear -- Nuke Propaganda Debunked, There IS NOT Any Significant Natural Radio-Isotopes Like Iodine 131 and Cesium 137 ... In July and August of 2015, Japan measured significant amount of Iodine 131 in sewage.. Since Iodine 131 has a fast half life ... So measuring Iodine 131 now, indicates that there is on-going fission at Fukushima. Note this is also before Sendai was ... Compare that to 49 Bq/kG of Iodine 131 measured in Japan. That is. 25,711,281,588 Times larger than "Natural". ...
more infohttp://www.nukepro.net/2015/08/lies-of-nuclear-nuke-propaganda.html

ASTM International - Standard References for ASTM D4785 - 08(2013)e1ASTM International - Standard References for ASTM D4785 - 08(2013)e1

ASTM D4785 - 08(2013)e1 Standard Test Method for Low-Level Analysis of Iodine Radioisotopes in Water. Citing ASTM Standards ...
more infohttps://www.astm.org/DATABASE.CART/STD_REFERENCE/D4785.htm

IB Chemistry/Atomic Theory - Wikibooks, open books for an open worldIB Chemistry/Atomic Theory - Wikibooks, open books for an open world

Larger doses of iodine radioisotopes can be used as therapy for thyroid cancer. ... so isotopes of iodine can be used to study thyroid disorders. Iodine-131 or iodine-125 are given to patients in very low doses ... The uses of radioisotopes[edit]. 14C in radiocarbon dating[edit]. Living things constantly accumulate carbon-14 but the isotope ... 4.2.6 The uses of radioisotopes *4.2.6.1 14C in radiocarbon dating ...
more infohttps://en.wikibooks.org/wiki/IB_Chemistry/Atomic_Theory

Effect of 1.11/1.85 versus 3.7 GBq iodine-131 under rhT | Open-iEffect of 1.11/1.85 versus 3.7 GBq iodine-131 under rhT | Open-i

Effect of 1.11/1.85 versus 3.7 GBq iodine-131 under rhTSH stimulation on thyroid remnant ablation rate according to ... Figure 2: Effect of 1.11/1.85 versus 3.7 GBq iodine-131 under rhTSH stimulation on thyroid remnant ablation rate according to ... Figure 2: Effect of 1.11/1.85 versus 3.7 GBq iodine-131 under rhTSH stimulation on thyroid remnant ablation rate according to ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3815118_mnm-34-1150-g003&req=4

TechConnect World 2019 Program - Wednesday June 19TechConnect World 2019 Program - Wednesday June 19

Microdosimetric calculations for Iodine radioisotopes using Geant4-DNA. B. Seniwal, T.C.F. Fonseca, Federal University of Minas ...
more infohttps://www.techconnectworld.com/World2019/wednesday.html

Immunoscintigraphy in medullary thyroid cancer using an 123I- or 111In-labelled monoclonal anti-CEA antibody fragment  -...Immunoscintigraphy in medullary thyroid cancer using an 123I- or 111In-labelled monoclonal anti-CEA antibody fragment -...

Iodine Radioisotopes/diagnostic use. MESH. Radioisotopes/diagnostic use. MESH. Thyroid Neoplasms/radionuclide imaging. MESH. ...
more infohttps://epub.uni-regensburg.de/21117/

adenocarcinoma in situ of lung diagnosis 2005:2010[pubdate] *count=100 - BioMedLib™ search engineadenocarcinoma in situ of lung diagnosis 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Iodine Radioisotopes / therapeutic use. Predictive Value of Tests. Thyroidectomy. *MedlinePlus Health Information. consumer ... Chemical-registry-number] 0 / Radioisotopes; 0 / Receptors, Somatostatin; 0 / somatostatin receptor 2; 2PK59M9GFF / vapreotide ...
more infohttp://www.bmlsearch.com/?kwr=adenocarcinoma+in+situ+of+lung+diagnosis+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Thyroid NoduleThyroid Nodule

Iodine Radioisotopes. 68. + +. 6. Iodine. 58. + +. 7. Sodium Pertechnetate Tc 99m. 48. + +. ...
more infohttps://lookfordiagnosis.com/results.php?symptoms=Thyroid+Nodule&lang=1&parent=%2F&mode=F&therapy_ap=1

Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean DeliveryChlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery

... chlorhexidine gluconate antiseptic vaginal preparation is superior to povidone-iodine vaginal preparati... ... Iodine Radioisotopes. Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights ... Iodine Isotopes. Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 ... Povidone-iodine. An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane ...
more infohttps://www.bioportfolio.com/resources/trial/179952/Chlorhexidine-Gluconate-Versus-Povidone-Iodine-as-Vaginal-Preparation-Antiseptics-Prior-to-Cesarean.html

Bronze Essay: Yourself as a writer essay paper writing online!Bronze Essay: Yourself as a writer essay paper writing online!

Then, in the title: Colonic neoplasms diagnosis, iodine radioisotopes diagnostic use iodine radioisotopes. See the following ...
more infohttp://owjn.org/20853-yourself-as-a-writer-essay/

copper-free-click-chemistry | China-Mainland | Sigma-Aldrichcopper-free-click-chemistry | China-Mainland | Sigma-Aldrich

Iodine radioisotope labeling of cyclooctyne-containing molecules by copper-free click reaction has been reported. ... This method is useful for both in vitro and in vivo labeling of DBCO group containing molecules with iodine radioisotopes.18 ...
more infohttps://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/chemistry/copper-free-click-chemistry.html

Copper-Free Click Chemistry | Sigma-AldrichCopper-Free Click Chemistry | Sigma-Aldrich

Iodine radioisotope labeling of cyclooctyne-containing molecules by copper-free click reaction has been reported. ... This method is useful for both in vitro and in vivo labeling of DBCO group containing molecules with iodine radioisotopes.14 ...
more infohttps://www.sigmaaldrich.com/technical-documents/articles/chemistry/copper-free-click-chemistry.html

Department of Radiology - Research Output
     - Penn StateDepartment of Radiology - Research Output - Penn State

Selective history of radioactive iodine in medicine: Inexactitudes no longer. Tulchinsky, M., Apr 1 2019, In : European Journal ... Re: Low-Dose Radioactive Iodine Ablation Is Sufficient in Patients with Small Papillary Thyroid Cancer Having Minor ... Well-founded recommendations for radioactive iodine treatment of differentiated thyroid cancer require balanced study of ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/department-of-radiology-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fletter

A radio-high-performance liquid chromatography dual-flow cell gamma-detection system for on-line radiochemical purity and...A radio-high-performance liquid chromatography dual-flow cell gamma-detection system for on-line radiochemical purity and...

Iodine Radioisotopes; Isotope Labeling; Limit of Detection; Radiopharmaceuticals; Technetium; Trimethyltin Compounds Main ...
more infohttps://www.forskningsdatabasen.dk/en/catalog/260792030

The thyroid gland is a major source of circulating T3 in the rat by Jean-Pierre Chanoine, Lewis E. Braverman et al."The thyroid gland is a major source of circulating T3 in the rat" by Jean-Pierre Chanoine, Lewis E. Braverman et al.

Animals; Iodide Peroxidase; Iodine; Iodine Radioisotopes; Kidney; Liver; Male; Rats; Selenium; Thyroid Gland; Thyroidectomy; ...
more infohttps://escholarship.umassmed.edu/oapubs/1003/

Find Publications
             - Oregon Health & Science UniversityFind Publications - Oregon Health & Science University

Hylen, J. C., Kloster, F. E., Herr, R. H., Hull, P. Q., Ames, A. W., Starr, A. & Griswold, H. E., Jul 1968, In : Circulation. 38, 1, p. 90-102 13 p.. Research output: Contribution to journal › Article ...
more infohttps://ohsu.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&page=1692

Coupling tandem affinity purification and quantitative tyrosine iodina by Corey Lewis Smith and Craig L. Peterson"Coupling tandem affinity purification and quantitative tyrosine iodina" by Corey Lewis Smith and Craig L. Peterson

Iodine Radioisotopes; Kinetics; Polymerase Chain Reaction; Radioisotope Dilution Technique; Tyrosine; Yeasts ...
more infohttps://escholarship.umassmed.edu/gsbs_sp/1129/
  • 【Abstract】: Objective To investigate the clinical effect of transarterial chemoembolization (TACE) combined with endovascular implantation of iodine-125 seeds in the treatment of primary liver cancer complicated by portal vein tumor thrombus (PVTT) and its influence on liver function. (lcgdbzz.org)
  • Conclusion TACE combined with endovascular implantation of iodine-125 seeds in the portal vein has a better clinical effect than TACE alone in the treatment of primary liver cancer complicated by PVTT, but more attention should be paid to liver impairment during treatment. (lcgdbzz.org)
  • The isotope I-131 is still occasionally used for purely diagnostic (i.e., imaging) work, due to its low expense compared to other iodine radioisotopes. (wikipedia.org)
  • By contrast, other iodine radioisotopes are usually created by far more expensive techniques, starting with reactor radiation of expensive capsules of pressurized xenon gas. (wikipedia.org)
  • Because of the routine availability of radioisotopes of iodine with different nuclear decay properties, radioiodination is an attractive strategy because the same chemistry can be utilized for both radionuclide imaging and targeted radiotherapy. (springer.com)
  • The low-cost availability of I-131, in turn, is due to the relative ease of creating I-131 by neutron bombardment of natural tellurium in a nuclear reactor, then separating I-131 out by various simple methods (i.e., heating to drive off the volatile iodine). (wikipedia.org)
  • He saw that if you take the atomic mass of chlorine, 2 add it to the atomic mass of iodine , divide by two, you get something that is really close to the atomic mass of bromine. (youdao.com)
  • Due to its mode of beta decay, iodine-131 is notable for causing mutation and death in cells that it penetrates, and other cells up to several millimeters away. (wikipedia.org)
  • Unlabelled tositumomab together with iodine-labelled tositumomab was called Bexxar and a personalized regimen using Bexxar was approved for the treatment of relapsed or chemotherapy/rituxan-refractory Non-Hodgkin lymphoma in 2003. (wikipedia.org)
  • Thus, iodine-131 is increasingly less employed in small doses in medical use (especially in children), but increasingly is used only in large and maximal treatment doses, as a way of killing targeted tissues. (wikipedia.org)
  • Since Iodine 131 has a fast half life of 8 days, it goes away pretty quick. (nukepro.net)