Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Intestines: The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.HomoarginineIsoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Enterocytes: Absorptive cells in the lining of the INTESTINAL MUCOSA. They are differentiated EPITHELIAL CELLS with apical MICROVILLI facing the intestinal lumen. Enterocytes are more abundant in the SMALL INTESTINE than in the LARGE INTESTINE. Their microvilli greatly increase the luminal surface area of the cell by 14- to 40 fold.TetramisoleIntestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Microvilli: Minute projections of cell membranes which greatly increase the surface area of the cell.GPI-Linked Proteins: A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Phosphoprotein Phosphatases: A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.Protein Tyrosine Phosphatases: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.Protein Phosphatase 2: A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Protein Phosphatase 1: A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Phosphoric Monoester Hydrolases: A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate. EC 3.1.3.Glucose-6-Phosphatase: An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9.Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Phosphates: Inorganic salts of phosphoric acid.Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Dual-Specificity Phosphatases: A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.Protein Tyrosine Phosphatase, Non-Receptor Type 11: A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.cdc25 Phosphatases: A subclass of dual specificity phosphatases that play a role in the progression of the CELL CYCLE. They dephosphorylate and activate CYCLIN-DEPENDENT KINASES.Protein Tyrosine Phosphatase, Non-Receptor Type 1: A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.Okadaic Acid: A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Protein Tyrosine Phosphatase, Non-Receptor Type 6: A Src-homology domain-containing protein tyrosine phosphatase found in the CYTOSOL of hematopoietic cells. It plays a role in signal transduction by dephosphorylating signaling proteins that are activated or inactivated by PROTEIN-TYROSINE KINASES.Myosin-Light-Chain Phosphatase: A phosphoprotein phosphatase that is specific for MYOSIN LIGHT CHAINS. It is composed of three subunits, which include a catalytic subunit, a myosin binding subunit, and a third subunit of unknown function.Kinetics: The rate dynamics in chemical or physical systems.Protein Tyrosine Phosphatases, Non-Receptor: A subcategory of protein tyrosine phosphatases that occur in the CYTOPLASM. Many of the proteins in this category play a role in intracellular signal transduction.Phosphorylase Phosphatase: An enzyme that deactivates glycogen phosphorylase a by releasing inorganic phosphate and phosphorylase b, the inactive form. EC 3.1.3.17.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Receptor-Like Protein Tyrosine Phosphatases, Class 2: A subclass of receptor-like protein tryosine phosphatases that contain multiple extracellular immunoglobulin G-like domains and fibronectin type III-like domains. An additional memprin-A5-mu domain is found on some members of this subclass.gamma-Glutamyltransferase: An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.Ethers, Cyclic: Compounds of the general formula R-O-R arranged in a ring or crown formation.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Cell Line: Established cell cultures that have the potential to propagate indefinitely.
Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI ... "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase ... "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells". Am. J ... 2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition". Proc. Natl. Acad. Sci ...
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/ ... 1993). "Chemical nature of intestinal-type alkaline phosphatase in human kidney". Clin. Chem. 38 (12): 2539-42. PMID 1458595. ... Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. ... "Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney". Mornet E (2000). "Hypophosphatasia: the mutations in the tissue- ...
... and alkaline phosphatase with MOS. To protect the villi and intestinal surface, the gut produces protecting mucus. This mucus ... Comparable changes in intestinal structure have also been reported in fish. In rainbow trout, supplementing the diet with 0.2% ... As MOS can bind E. coli (see Effects of MOS on the intestinal microflora), it can modify and help to improve the composition of ... The change from milk to solid feed leads to changes in the intestinal microflora and structure and thus presents a higher risk ...
It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor ... Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA (August 2005). "Differential regulation of intestinal alkaline phosphatase ... with high expression in intestinal crypts and diminishing expression along intestinal villi. This gene is a member of the ... Therefore, along with its known roles in intestinal patterning and differentiation, CDX1 is also shown to be important in ...
Calf intestines supply calf-intestinal alkaline phosphatase (CIP), and are used to make goldbeater's skin. Other uses are: The ... The gastro intestinal tract in the Human Protein Atlas Your Digestive System and How It Works at National Institutes of Health ... Intestinal pseudo-obstruction is a syndrome caused by a malformation of the digestive system, characterized by a severe ... The area of the human, adult small intestinal mucosa is about 30 m2. Its main function is to absorb the products of digestion ( ...
Bates JM, Akerlund J, Mittge E, Guillemin K (2007). "Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents ... It has recently been shown that a specific enzyme in the intestine (alkaline phosphatase) can detoxify LPS by removing the two ... Moreover, endotoxemia of intestinal origin, especially, at the host-pathogen interface, is considered to be an important factor ... Parlesak A, Schäfer C, Schütz T, Bode JC, Bode C (2000). "Increased intestinal permeability to macromolecules and endotoxemia ...
"Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor". ... terminal cell differentiation and proper localization of the different intestinal epithelium cell types). In the intestinal ... This population of intestinal stem cells: are normally slow dividing, are known to be resistant to radiation injury, and are ... Recently a group investigated the role of KLF4 in a particular population of intestinal stem cells, the Bmi1+ stem cells. ...
The intestine is used to make Goldbeater's skin, and is the source of Calf Intestinal Alkaline Phosphatase (CIP). Dairy cows ...
A phosphatase, commonly calf-intestinal alkaline phosphatase (CIAP), is also added to prevent self-ligation of the destination ...
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/ ... that is closely related to both the placental and intestinal forms of alkaline phosphatase. GRCh38: Ensembl release 89: ... Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene. ... Shen LP, Liu H, Kan YW, Kam W (June 1988). "5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene ...
NPP's promiscuity enables the enzyme to share substrates with alkaline phosphatase (AP), another member of the alkaline ... Intestinal NPP3 would be involved in hydrolyzing food-derived nucleotides. The liver releases ATP and ADP into the bile to ... NPP belongs to the alkaline phosphatase (AP) superfamily of enzymes. Humans express seven known NPP isoforms, some of which ... Alkaline phosphatase primarily hydrolyzes phosphate monoester bonds, but interestingly it shows some promiscuity towards ...
... alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase ... Van Belle, H. (1976). "Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans". Clin ... Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and ... spleen) except the intestinal and placental isoform. It is thus used as an inhibitor along with substrate to reduce background ...
... is dephosphorylated to S-benzoylthiamine by ecto-alkaline phosphatases present in the intestinal mucosa, and is ...
... alkaline phosphatase, and bilirubin levels. Folate level is reduced in alcoholic patients due to decreased intestinal ... One possible mechanism for the increased activity of TNF-α is the increased intestinal permeability due to liver disease. This ...
Dephosphorylation is commonly done using calf-intestinal alkaline phosphatase (CIAP) which removes the phosphate group from the ... Shrimp alkaline phosphatase (SAP) or Antarctic phosphatase (AP) are suitable alternative as they can be easily inactivated. ...
Alkaline phosphatase levels are usually elevated in hyperparathyroidism. In primary hyperparathyroidism, levels may remain ... allowing flow of calcium from bone to blood reduced kidney clearance of calcium increased intestinal calcium absorption In ...
The T-cell marker Thy-1 and acetylcholinesterase, as well as both intestinal and placental alkaline phosphatases, are known to ...
Human-intestinal alkaline phosphatase. The human body has multiple types of alkaline phosphatase present, which are determined ... Calf-intestinal alkaline phosphatase (CIP) Placental alkaline phosphatase (PLAP) and its C terminally truncated version that ... Alkaline phosphatase has a Km of 8.4 x 10−4. Alkaline phosphatase in E. coli is uncommonly soluble and active within elevated ... Alkaline phosphatase accounts for 6% of all proteins in depressed cells. Bacterial alkaline phosphatase (BAP) is the most ...
There are at least four distinct but related alkaline phosphatases: intestinal (ALPI), placental (this enzyme), placental-like ... Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans ... for this form of alkaline phosphatase have been well-characterized. Alkaline phosphatase, placental type is a membrane-bound ... "Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme)". "European Group on Tumor Markers. A European Based Expert ...
... (CIAP/CIP) is a type of alkaline phosphatase that catalyzes the removal of phosphate ...
... and alkaline phosphatase (ALP); bilirubin (which causes the jaundice); and protein levels, specifically, total protein and ... Intestinal bacteria convert the bilirubin into urobilinogen. From here urobilinogen can take two pathways. It can either be ... or it can be reabsorbed by the intestinal cells, transported in the blood to the kidneys, and passed out in the urine as the ...
Alican, Fikri; Hardy, James D. (August 1962). "Lymphatic Transport of Bile Pigments and Alkaline Phosphatase in Experimental ... His research focused largely on the lungs and on the liver, though he is also known for his work on intestinal transplantation ... and Alkaline Phosphatase in Lymph, Blood, and Urine After Ligation of the Common Bile Duct". Surgical Forum. 12: 337-339. ISSN ... "Intestinal Transplantation: Laboratory Experience and Report of a Clinical Case". The American Journal of Surgery. 121 (2): 150 ...
A serum alkaline phosphatase less than 1.5 times the upper limit of normal has been associated with better outcomes but its ... The primary physiological function of bile is to assist in the breakdown and absorption of fat in the intestinal tract; a ... serum alkaline phosphatase (ALP) > 1.5x the upper limit of normal for longer than 6 months; cholangiography demonstrating ... Data have provided novel insights suggesting: an important association between the intestinal microbiota and PSC and a process ...
1979) found that there are at least three varieties of akaline phosphatases, kidney, liver, and bone alkaline phosphatases, ... "Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of ... The alkaline phosphatase varieties, therefore, express a unique complement of in the enzymatic processes in post-translational ... Alkaline phosphatase activity correlates with the morphology changes. Initial deacetylation of histone is required for ...
Such transporter molecules include schistosome alkaline phosphatase (SmAP) and cathepsin B, which may be important in nutrient ... 2011). "Intestinal Perforation due to Tapeworm: Taenia Solium". Journal of Clinical and Diagnostic Research. 5: 1101-1103. Hall ... Bhardwaj and Skelly (2011). "Characterization of Schistosome Tegumental Alkaline Phosphatase (SmAP)". PLoS Neglected Tropical ... 2006). "A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite". The Journal of Biological ...
negative regulation of alkaline phosphatase activity. • regulation of I-kappaB kinase/NF-kappaB signaling. • defense response ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... negative regulation of myosin-light-chain-phosphatase activity. • negative regulation of transcription, DNA-templated. • ...
Recombinant Human intestinal alkaline phosphatase protein is a Wheat germ Protein fragment 74 to 162 aa range and validated in ...
... of either bone or liver alkaline phosphatase activity remained when alkaline phosphatase activity was inhibited in a 2-amino-2- ... Intestinal alkaline phosphatase activity was measured using levamisole inhibition, and results were compared with a previously ... Quantitative method for determining serum alkaline phosphatase isoenzyme activity: estimation of intestinal component. ... Quantitative method for determining serum alkaline phosphatase isoenzyme activity: estimation of intestinal component. ...
... is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific isoenzyme of alkaline ... phosphatase (TNSALP). TNSALP is a phosphomonoesterase of 507 residues and is anchored at its carboxyl terminus to the plasma ... Three of these isoforms are tissue specific and are known as germ cell, placental, and intestinal alkaline phosphatase. The ... 1] Patients presenting with abnormal bone features should undergo alkaline phosphatase and vitamin B6 testing to rule out this ...
Suzuki K, Yoshimura Y, Hisada Y, Matsumoto A. Sensitivity of intestinal alkaline phosphatase to L-homoarginine and its ... Similarly, we examined the relationship of homoarginine with alkaline phosphatase, which was previously shown to be inhibited ... and alkaline phosphatase (r=−0.22, P,0.001). Furthermore, homoarginine levels showed significant negative associations with the ... l-Homoarginine: an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases. J Biol Chem. ...
1987) Human placental and intestinal alkaline phosphatase genes map to 2q34eq37. Am J Hum Genet 41: 1025-1034 [Crossref] ... Even level of alkaline phosphatase improved significantly gradually, on discharged the ALP 102 UL .She weaned from ventilator ... Harris H (1990) The human alkaline phosphatases: what we know and what we dont know. Clin Chim Acta 186: 133-150. [Crossref] ... The disease is due to mutations in the alkaline phosphatase liver-type (ALPL) gene, also named the TNSALP gene. ...
Calf-intestinal alkaline phosphatase (CIAP/CIP) is a type of alkaline phosphatase that catalyzes the removal of phosphate ...
ALPI alkaline phosphatase, intestinal [Homo sapiens] ALPI alkaline phosphatase, intestinal [Homo sapiens]. Gene ID:248 ... intestinal-type alkaline phosphatase. Names. Kasahara isozyme. alkaline phosphomonoesterase. glycerophosphatase. intestinal ... Title: The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by ... Expressions of human intestinal alkaline phosphatase and sucrase-isomaltase, which are intestinal differentiation markers, were ...
IPR017849. Alkaline_Pase-like_a/b/a. IPR001952. Alkaline_phosphatase. IPR018299. Alkaline_phosphatase_AS. IPR017850. Alkaline_ ... IPR017849. Alkaline_Pase-like_a/b/a. IPR001952. Alkaline_phosphatase. IPR018299. Alkaline_phosphatase_AS. IPR017850. Alkaline_ ... sp,P51740,PPBI2_RAT Intestinal-type alkaline phosphatase 2 OS=Rattus norvegicus PE=1 SV=1 ... Intestinal-type alkaline phosphatase 2Add BLAST. 512. ,p>This subsection of the ,a href="http://www.uniprot.org/help/ptm_ ...
C. Lee, J. Chun, S. W. Hwang, S. J. Kang, J. P. Im, and J. S. Kim, "The effect of intestinal alkaline phosphatase on intestinal ... J.-P. Lallès, "Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and ... intestinal, placental, and germ cell type of the enzyme [1, 2]. Intestinal alkaline phosphatase (IAP) exhibits its biological ... "Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage," European Journal of ...
Rabbit polyclonal intestinal alkaline phosphatase antibody. Validated in WB, IHC and tested in Human. Cited in 1 publication(s ... Anti-Human intestinal alkaline phosphatase antibody. See all intestinal alkaline phosphatase primary antibodies. ... Anti-Human intestinal alkaline phosphatase antibody Rating: Inconclusive Image: Anti-Human intestinal alkaline phosphatase ... The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone ...
bovine intestinal alkaline phosphatase (bIAP) in reducing the pro-inflammatory post-. surgical responses and thereby preserving ... Home » Topics » Veterinary » Research » Efficacy and Safety of Bovine Intestinal Alkaline Phosphatase (bIAP) During Heart ... More From BioPortfolio on "Efficacy and Safety of Bovine Intestinal Alkaline Phosphatase (bIAP) During Heart Surgery". *Related ... Efficacy and Safety of Bovine Intestinal Alkaline Phosphatase (bIAP) During Heart Surgery. 2014-08-27 03:12:54 , BioPortfolio ...
Rabbit Polyclonal Intestinal Alkaline Phosphatase antibody for IHC (p), ELISA, WB. Order anti-Intestinal Alkaline Phosphatase ... anti-Intestinal Alkaline Phosphatase antibody (Alkaline Phosphatase, Intestinal) Intestinal Alkaline Phosphatase antibody ( ... anti-Alkaline Phosphatase, Intestinal (ALPI) antibody anti-Alkaline Phosphatase, Intestinal (ALPI) antibody Read product ... anti-Alkaline Phosphatase, Intestinal (ALPI) antibody anti-Alkaline Phosphatase, Intestinal (ALPI) antibody Read product ...
Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme that is shown to function as a gut mucosal defense ... The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in mice.. [ ... Human intestinal epithelial cells COLO 205 and peritoneal macrophages from IL-10(-/-) mice were pretreated with IAP and then ... The aims of this study were to evaluate the effect of IAP on intestinal epithelial cells and macrophages, and on chronic ...
Jetzt diesen anti-Intestinal Alkaline Phosphatase Antikörper bestellen. , Produkt ABIN559857 ... Maus Monoklonal Intestinal Alkaline Phosphatase Antikörper AA 74-162, partial für ELISA, WB. Publiziert in 1 Pubmed Referenz. ... anti-Intestinal Alkaline Phosphatase Antikörper (Alkaline Phosphatase, Intestina... Intestinal Alkaline Phosphatase Antikörper ... Weitere Produktkategorien zu Intestinal Alkaline Phosphatase Primärantikörper * 280 anti-Intestinal Alkaline Phosphatase ...
... uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase. ...
SAR analysis of small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay. ...
GoPubMed lists recent and important papers and reviews for ALPI alkaline phosphatase, intestinal(intestinal alkaline ... Phosphatase assays using Calf intestinal alkaline phosphatase and Lambda protein phosphatase followed by nanofluidic proteomic ... Intestinal alkaline phosphatase (IAP) plays an essential role in intestinal homeostasis and health through interactions with ... Important protective roles of intestinal alkaline phosphatase (IAP)--including regulation of intestinal surface pH, absorption ...
Objectives We encountered a case with benign familial hyperphosphatasaemia of intestinal alkaline phosphatase (IAP). To ... Variant in C-terminal region of intestinal alkaline phosphatase associated with benign familial hyperphosphatasaemia ... Variant in C-terminal region of intestinal alkaline phosphatase associated with benign familial hyperphosphatasaemia ...
New Procedure for Purifying and Crystallizing Alkaline Phosphatase from Human Intestinal Mucosa. Sheshadri Narayanan, Harold D. ... New Procedure for Purifying and Crystallizing Alkaline Phosphatase from Human Intestinal Mucosa ... New Procedure for Purifying and Crystallizing Alkaline Phosphatase from Human Intestinal Mucosa ... and crystallizing alkaline phosphatase orthophosphoric monoester phosphohydrolase (EC 3.1.3.1) from human intestinal mucosa. ...
Anti-Calf Intestinal Alkaline Phosphatase Antibody (Serum), Goat Anti-Bovine Polyclonal Antibody validated in IHC-P, IHC-F, E ( ... Intestinal-type alkaline phosphatase, IAP, Intestinal alkaline phosphatase, 3.1.3.1, ALPI. Target/Specificity ABD10274 ... Anti-Calf Intestinal Alkaline Phosphatase Antibody (Serum) Anti-Calf Intestinal Alkaline Phosphatase Antibody (Serum). Goat ... Anti-Calf Intestinal Alkaline Phosphatase Antibody (Serum) is for research use only and not for use in diagnostic or ...
alkaline phosphatase. IALPs. intestinal alkaline phosphatases. IVIVC. in vitro-to-in vivo correlation. RIMS. rat intestinal ... Intestinal alkaline phosphatases (IALPs) are widely expressed in the brush border of epithelial cells of the intestinal mucosa ... 2009) Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol 587:3651-3663. ... Recombinant Intestinal Alkaline Phosphatase Characterization. Murali Subramanian, Sundeep Paruchury, Shashyendra Singh Gautam, ...
... intestinal-type alkaline phosphatase, alkaline phosphatase, alkaline phosphomonoesterase, IAP, Intestinal alkaline phosphatase ... Anti-Alkaline Phosphatase, Intestinal Mouse Monoclonal Antibody (DyLight 488) [clone: AAP1]. Anti-Alkaline Phosphatase, ... Intestinal. This antibody reacts with human. The Alkaline Phosphatase, Intestinal Antibody (AAP1) [DyLight 488] has been ... The Alkaline Phosphatase, Intestinal Antibody (AAP1) [DyLight 488] from Novus Biologicals is a mouse monoclonal antibody to ...
glycerophosphatase, intestinal, intestinal-type alkaline phosphatase, alkaline phosphatase, Kasahara isozyme, EC 3.1.3.1, IAP, ... Anti-Alkaline Phosphatase, Intestinal Mouse Monoclonal Antibody (DyLight 488) [clone: AP1B9]. Anti-Alkaline Phosphatase, ... Intestinal. This antibody reacts with human, bovine. The Alkaline Phosphatase, Intestinal Antibody (AP1B9) [DyLight 488] has ... The Alkaline Phosphatase, Intestinal Antibody (AP1B9) [DyLight 488] from Novus Biologicals is a mouse monoclonal antibody to ...
Cloning and sequencing of human intestinal alkaline phosphatase cDNA. ... CLIA Alpi,IAP-1,IAP-I,Intestinal alkaline phosphatase 1,Intestinal alkaline phosphatase I,Intestinal-type alkaline phosphatase ... ELISA Alpi,IAP-1,IAP-I,Intestinal alkaline phosphatase 1,Intestinal alkaline phosphatase I,Intestinal-type alkaline phosphatase ... Intestinal alkaline phosphatase 1,Intestinal alkaline phosphatase I,Intestinal-type alkaline phosphatase 1,Rat,Rattus ...
Our knowledge of the structure and function of alkaline phosphatases has increased greatly in recent years. The crystal ... Intestinal alkaline phosphatase can transphosphorylate thiamin to thiamin monophosphate during intestinal transport in the rat ... Mammalian intestinal alkaline phosphatase acts as highly active exopolyphosphatase. Biochim Biophys Acta 2001; 1547: 254-61. ... Mammalian alkaline phosphatases are allosteric enzymes. J Biol Chem 1997; 272: 22781-7.CrossRefPubMedGoogle Scholar ...
  • Perinatal HHP: associated with profound inactivity of alkaline phosphatase and markedly impaired mineralization with clinically apparent skeletal deformities and pathognomonic radiographic changes with rapidly progressive clinical course. (oatext.com)
  • Previous work has revealed that the zebrafish intestinal alkaline phosphatase (ALPI) is induced by bacterial lipopolysaccharide (LPS) and functions to detoxify LPS and prevent excessive inflammatory responses to the gut microbiota. (asm.org)
  • Initially recognized by Rathbun in 1948, HPP is a rare inborn error of metabolism caused by mutations in the ALPL gene located on chromosome 1 (1p36.1) and consists of 12 exons distributed over 50 kb, encoding tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). (medscape.com)
  • Fusion of tumorigenic HeLa cells with human skin fibroblasts results in genetically stable hybrids which are nontumorigenic and no longer express the HeLa tumor-associated antigen, intestinal alkaline phosphatase (IAP). (elsevier.com)
  • The assay imprecision (SD) was 0.6 U/l compared with 3.9 U/l using L-phenylalanine for specimens with total alkaline phosphatase activity less than 250 U/l (reference range 30-120 U/l). (bmj.com)
  • The identification of the source of a raised total alkaline phosphatase activity in plasma, by the measurement of individual ALP forms, is of clinical value although many of the methods available for this purpose are complex, imprecise and non-specific. (bl.uk)
  • Due to space constraints this mini-review focuses exclusively on structural and functional features of mammalian alkaline phosphatases as identified by crystallography and probed by site-directed mutagenesis and kinetic analysis. (springer.com)
  • It maintains a healthy gastrointestinal environment through regulating pH, dampening inflammation, regulating the microbiome, and maintaining intestinal barrier integrity. (hackyourgut.com)
  • Important protective roles of intestinal alkaline phosphatase (IAP)--including regulation of intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial lipopolysaccharide, attenuation of intestinal inflammation, and possible modulation of the gut microbiota--have been reviewed recently. (gopubmed.org)
  • As mentioned earlier MOS affects bacterial attachment in the intestinal tract. (wikipedia.org)
  • This leads to intestinal discomfort, incomplete digestion of food, and establishes a favorable environment for foreign bacterial and fungal growth. (nutrametrix.com)
  • Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn-site infection. (harvard.edu)
  • A critical study of the histochemical techniques for acid phosphatase with a description of an azo-dye method. (springer.com)
  • The stability of so-called axonal acid phosphatase as determined by experiments in its stainibility. (springer.com)
  • By using a pair-feeding design, we attributed these effects as direct consequences of heat stress via impaired intestinal barrier function. (pnas.org)
  • Vitamin D is essential for active intestinal calcium absorption and plays a central role in maintaining calcium homeostasis and skeletal integrity. (cdc.gov)
  • This observational should investigate the association of total and skeletal alkaline phosphatase (AP) with mortality of patients undergoing maintenance renal replacement therapy. (bmj.com)
  • Intestinal alkaline phosphatase: a summary of its role in clinical disease. (nih.gov)
  • Only three laboratory markers were consistently abnormal, in evaluating for metastatic carcinoma of breast, prior to clinical detectability of metastases: these were alkaline phosphatase, GT and CEA. (labcorp.com)
  • Synthetic Biologics, Inc. (NYSE American: SYN), a diversified clinical-stage company leveraging the microbiome to develop therapeutics designed to prevent and treat gastrointestinal ('GI') diseases in areas of high unmet need, today announced that it submitted an Investigational New Drug ('IND') application with the U.S. Food and Drug Administration ('FDA') for its SYN-020 Intestinal Alkaline Phosphatase ('IAP') program. (yahoo.com)
  • As reported with the IGG receptor, therefore the intestinal ALP from rats exist in both peptide-anchored and GPI-anchored forms. (nii.ac.jp)
  • Publications] S.Unakami,T.Komoda,Y.Sakagishi: 'Translocation of intestinal alkaline phosphatase in streptozotocininduced diabetic rats. (nii.ac.jp)
  • IAP present in the apical microvilli of the brush border of enterocytes and secreted into both the intestinal lumen and the bloodstream has been considered as gut mucosal defence factor essential for maintaining gut homeostasis [ 3 - 5 ]. (hindawi.com)
  • Probiotic GS4 intervention reduced the intestinal structural deformities as evident from the elevated brush border membrane-associated disaccharidases (sucrase, lactase) and intestinal alkaline phosphatase activities, which were found disrupted by AOM intoxication. (gopubmed.org)
  • Intestinal alkaline phosphatase(IAP) gets secreted at the brush border and travels through the digestive tract, primarily with meals. (hackyourgut.com)
  • There is a change in pH as you move from the lumen(A), through the mucus(B), to the brush border(B/C). The pH in the lumen tends to be more acidic and gets more alkaline as you get closer to the brush border. (hackyourgut.com)