Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A type of CARTILAGE whose matrix contains large bundles of COLLAGEN TYPE I. Fibrocartilage is typically found in the INTERVERTEBRAL DISK; PUBIC SYMPHYSIS; TIBIAL MENISCI; and articular disks in synovial JOINTS. (From Ross et. al., Histology, 3rd ed., p132,136)
The spinal or vertebral column.
The dissolving of the nucleus pulposus, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
Excision, in part or whole, of an INTERVERTEBRAL DISC. The most common indication is disk displacement or herniation. In addition to standard surgical removal, it can be performed by percutaneous diskectomy (DISKECTOMY, PERCUTANEOUS) or by laparoscopic diskectomy, the former being the more common.
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
Region of the back including the LUMBAR VERTEBRAE, SACRUM, and nearby structures.
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.
A group of twelve VERTEBRAE connected to the ribs that support the upper trunk region.
A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
X-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.
Glycoproteins which have a very high polysaccharide content.
Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.
The 3(S)-endo isomer of atropine.
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
Percutaneous excision of a herniated or displaced INTERVERTEBRAL DISC by posterolateral approach, always remaining outside the spinal canal. Percutaneous nucleotomy was first described by Hijikata in Japan in 1975. In 1985 Onik introduced automated percutaneous nucleotomy which consists in percutaneous aspiration of the nucleus pulposus. It is carried out under local anesthesia, thus reducing the surgical insult and requiring brief hospitalization, often performed on an outpatient basis. It appears to be a well-tolerated alternative to surgical diskectomy and chymopapain nucleolysis.
Forward displacement of a superior vertebral body over the vertebral body below.
Narrowing of the spinal canal.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)
A dead body, usually a human body.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
The replacement of intervertebral discs in the spinal column with artificial devices. The procedure is done in the lumbar or cervical spine to relieve severe pain resulting from INTERVERTEBRAL DISC DEGENERATION.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.
The cavity within the SPINAL COLUMN through which the SPINAL CORD passes.
Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Polymorphic cells that form cartilage.
A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)
A small leucine-rich proteoglycan found in a variety of tissues including CAPILLARY ENDOTHELIUM; SKELETAL MUSCLE; CARTILAGE; BONE; and TENDONS. The protein contains two glycosaminoglycan chains and is similar in structure to DECORIN.
A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.
An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
A computer based method of simulating or analyzing the behavior of structures or components.
Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.
An anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain.
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.
The anterior concavity in the curvature of the lumbar and cervical spine as viewed from the side. The term usually refers to abnormally increased curvature (hollow back, saddle back, swayback). It does not include lordosis as normal mating posture in certain animals ( = POSTURE + SEX BEHAVIOR, ANIMAL).
Internal devices used in osteosynthesis to hold the position of the fracture in proper alignment. By applying the principles of biomedical engineering, the surgeon uses metal plates, nails, rods, etc., for the correction of skeletal defects.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
The joint that occurs between facets of the interior and superior articular processes of adjacent VERTEBRAE.
The physiological renewal, repair, or replacement of tissue.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A type II keratin found associated with KERATIN-18 in simple, or predominately single layered, internal epithelia.
Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Space between the dura mater and the walls of the vertebral canal.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Deficient development or degeneration of a portion of the VERTEBRA, usually in the pars interarticularis (the bone bridge between the superior and inferior facet joints of the LUMBAR VERTEBRAE) leading to SPONDYLOLISTHESIS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.
Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film).
Surgical insertion of a prosthesis.
The pull on a limb or a part thereof. Skin traction (indirect traction) is applied by using a bandage to pull on the skin and fascia where light traction is required. Skeletal traction (direct traction), however, uses pins or wires inserted through bone and is attached to weights, pulleys, and ropes. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed)
A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; COSTAL CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A plate of fibrous tissue that divides the temporomandibular joint into an upper and lower cavity. The disc is attached to the articular capsule and moves forward with the condyle in free opening and protrusion. (Boucher's Clinical Dental Terminology, 4th ed, p92)
A growth differentiation factor that plays a role in early CHONDROGENESIS and joint formation.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

A comparative chemical and histochemical study of the chondrodystrophoid and nonchondrodystrophoid canine intervertebral disc. (1/1257)

The chemical composition of the intervertebral disc of 9-month-old chondrodystrophoid and nonchondrodystrophoid dogs was studied for collagen, noncollagenous protein and glycosaminoglycan. Content of these substances differed significantly between breeds. The differences were most marked in the nucleus pulposus; the noncollagenous protein content of the nonchondrodystrophoid breed was higher than in that of the chondrodystrophoid dogs. The total nitrogen value of the nonchondrodystrophoid nuclei pulposi was less than that of the corresponding chondrodystrophoid discs mainly because of the high collagen content of the latter discs. Histochemically, it was found that the nuclei pulposi of the nonchondrodystrophoid breed contains larger amounts of glycosaminoglycan than in the discs of the chondrodystrophoid breeds.  (+info)

Extradural inflammation associated with annular tears: demonstration with gadolinium-enhanced lumbar spine MRI. (2/1257)

Annular tears are manifest on MRI as the high-intensity zone (HIZ) or as annular enhancement. Patients with annular tears may experience low back pain with radiation into the lower limb in the absence of nerve root compression. Inflammation of nerve roots from leak of degenerative nuclear material through full-thickness annular tears is a proposed mechanism for such leg pain. The aim of this study is to illustrate the appearance of extradural enhancement adjacent to annular tears in patients being investigated for low back pain with radiation into the lower limb(s). Sagittal T1- and T2-weighted spin echo and axial T1-weighted spin echo sequences were obtained in eight patients being investigated for low back and leg pain. In all patients, the T1-weighted sequences were repeated following intravenous gadopentetate dimeglumine (Gd-DTPA). Annular tears were identified at 12 sites in eight patients. Extradural inflammation appeared as a region of intermediate signal intensity replacing the fat between the posterior disc margin and the theca, which enhanced following Gd-DTPA. The inflammatory change was always associated with an annular tear, and in four cases directly involved the nerve root. Enhancement of the nerve root was seen in two cases. The findings may be relevant in the diagnosis of chemical radiculopathy secondary to inflammation at the site of an annular leak from a degenerating disc.  (+info)

A clinico-pathological study of cervical myelopathy in rheumatoid arthritis: post-mortem analysis of two cases. (3/1257)

Two patients who developed cervical myelopathy secondary to rheumatoid arthritis were analyzed post mortem. One patient had anterior atlanto-axial subluxation (AAS) combined with subaxial subluxation (SS), and the other had vertical subluxation (VS) combined with SS. In the patient with AAS, the posterior aspect of the spinal cord demonstrated severe constriction at the C2 segment, which arose from dynamic osseous compression by the C1 posterior arch. A histological cross-section of the spinal cord at the segment was characterized by distinct necrosis in the posterior white columns and the gray matter. In the patient with VS, the upper cervical cord and medulla oblongata showed angulation over the invaginated odontoid process, whereas no significant pathological changes were observed. At the level of SS, the spinal cord was pinched and compressed between the upper corner of the vertebral body and the lower edge of the lamina. Histologically, demyelination and gliosis were observed in the posterior and lateral white columns.  (+info)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (4/1257)

The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up.  (+info)

Cervical spondylotic myelopathy in elderly people: a high incidence of conduction block at C3-4 or C4-5. (5/1257)

OBJECTIVES: To precisely localise the site of conduction block in elderly patients with cervical spondylotic myelopathy in the presence of multilevel compression shown by MRI. METHODS: A total of 44 patients aged 65 and older underwent serial intervertebral recording of spinal somatosensory evoked potentials (SSEPs) from either the intervertebral disc or the ligamentum flavum after epidural stimulation. The site of conduction block identified by abrupt reduction in size of the negative peak was designated as the 0 level with the other levels numbered in order of distance assigning a minus sign caudally. RESULTS: A single site of focal conduction block was disclosed in 42 patients, 23 (55%) at C3-4, 17 (40%) at C4-5, and two (5%) at C5-6. At these levels (0), the amplitude of the negative component was reduced (p<0.0001) to 29% and the area to 22%, with a concomitant increase (p<0.0001) of the initial positive component to 150% in amplitude and 293% in area as compared to the-2 level which was taken as the baseline (100%). CONCLUSIONS: A high incidence (95%) of focal conduction block at C3-4 or C4-5 with normal conduction at C5-6 and C6-7 characterises cervical spondylotic myelopathy in elderly people. Incremental SSEP studies documenting the site of conduction block will help exclude clinically silent cord compression, directing the surgical intervention to the appropriate level of concern.  (+info)

Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases. (6/1257)

The MR imaging findings of fungal spinal osteomyelitis in three recipients of organ transplants showed hypointensity of the vertebral bodies on T1-weighted sequences in all cases. Signal changes and enhancement extended into the posterior elements in two cases. Multiple-level disease was present in two cases (with a total of five intervertebral disks involved in three cases). All cases lacked hyperintensity within the disks on T2-weighted images. In addition, the intranuclear cleft was preserved in four of five affected disks at initial MR imaging. MR features in Candida and Aspergillus spondylitis that are distinct from pyogenic osteomyelitis include absence of disk hyperintensity and preservation of the intranuclear cleft on T2-weighted images. Prompt recognition of these findings may avoid delay in establishing a diagnosis and instituting treatment of opportunistic osteomyelitis in the immunocompromised patient.  (+info)

Lumbar intradiscal pressure after posterolateral fusion and pedicle screw fixation. (7/1257)

In vitro biomechanical testing was performed in single-functional spinal units of fresh calf lumbar spines, using pressure needle transducers to investigate the effect of posterolateral fusion (PLF) and pedicle screw constructs (PS) on intradiscal pressure (IDP), in order to elucidate the mechanical factors concerned with residual low back pain after PLF. IDP of 6 calf lumbar spines consisting of L4 and L5 vertebrae and an intervening disc was measured under axial compression, flexion-extension and lateral bending in the intact spine, PS, PLF and the destabilized spine. Relative to the intact spines, the destabilized spines showed increased IDP in all of lordings and moments. IDP under PS and PLF were significantly decreased in axial compression, extension and lateral bending loads (p<0.05). In flexion, IDP under PS and PLF increased linearly proportional to the magnitude of flexion moment and reached as high as IDP of the intact spines. These results demonstrated that despite an increase in the stiffness of motion segments after PLF and PS, significant high disc pressure is still generated in flexion. Flexibility of PS and PLF may cause increased axial load sharing of the disc in flexion and increased IDP. This high IDP may explain patients' persisting pain following PS and PLF.  (+info)

Relationship of pain drawings to invasive tests assessing intervertebral disc pathology. (8/1257)

It has been found that the pain patterns in pain drawings are related to the presence of herniated disc identified by myelography. The purpose of this study was to determine whether the pattern of pain in the drawings or the type of pain indicated (aching, burning, numbness, pins and needles, stabbing) was related to the presence of symptomatic disc pathology identified by CT/discography. In a subgroup of patients who underwent myelography, the relationship of the drawings to myelographic findings was also investigated. Pain drawings were completed by 187 patients with low back and/or radicular pain who were undergoing CT/discography. The drawings were scored in two ways, first by the system described by Ransford and secondly by visual inspection. They were classified as being indicative, or not, of disc pathology. The CT/discograms were classified as disrupted, or not, and the pain responses were recorded upon injection of each disc, based on the similarity of the pain provoked to clinical symptoms. Among the 133 patients with discogenic pain confirmed by discography, 110 (82.7%) had pain drawings that were classified as indicative. Among the 45 patients without discogenic pain, 29 (64.4%) had pain drawings classified as non-indicative. Patients with discogenic pain used more symbols indicating burning pain and aching pain than did non-discogenic pain patients. Our results confirmed those reported earlier by Uden, who found a relationship between the pattern of pain in the drawings and myelographic findings. Pain drawings may be helpful in the diagnosis of symptomatic disc pathology.  (+info)

Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a continuous measure has made it difficult to sensitively examine degenerative disc disease. This study sought to examine the relationship between disc degeneration and intervertebral disc height. 72 community-based individuals not selected for low back pain had MRI from which the presence of lumbosacral disc degeneration was identified using the Pfirrmann grading system, and intervertebral disc height was measured. At each lumbosacral level, with higher grade of disc degeneration, intervertebral disc height was reduced (all p ≤ 0.003). Results remained unchanged when grade 5 disc degeneration, which necessitated a collapsed disc space, was excluded from analyses (all p ≤ 0.03). To quantify these
TY - JOUR. T1 - The interaction between co-cultured human nucleus pulposus cells and mesenchymal stem cells in a bioactive scaffold. AU - Wu, Chang Chin. AU - Yang, Shu Hua. AU - Huang, Teng Le. AU - Liu, Chia Ching. AU - Lu, Dai Hua. AU - Yang, Kai Chiang. AU - Lin, Feng Huei. PY - 2012/6. Y1 - 2012/6. N2 - Mesenchymal stem cells (MSCs) can differentiate into nucleus pulposus (NP) cells upon being co-cultured with NP cells. Important growth factors and morphogens secreted by MSCs during the differentiation process also enhance the biological properties of NP cells. In this study, the interactions between human NP cells and MSCs co-cultured in different cell-ratio (100% NP, 75% NP with 25% MSCs, 50% NP with 50% MSCs, 25% NP with 75% MSCs, and 100% MSCs) in a three-dimensional gelatin/chondroitin-6-sulfate/hyaluronan tri-copolymer scaffold were examined. Results showed that the cell proliferation was increased when NP and MSCs were co-cultured. Real-time PCR and immunohistochemical staining ...
The aim of this study was to determine if treatment with reversine, a purine analog, promoted generation of skeletal progenitor cells from lineage-committed annulus fibrosus cells. Reversine modulated cell growth, morphology, and the actin cytoskeleton of annulus fibrosus cells. Microarray profiling coupled with Ingenuity Pathway Analysis revealed that reversine treatment resulted in a significant expression change in many genes including those required for cell-cell interaction, cell movement, cell growth, and development. Further analysis revealed that there was involvement of gene networks concerned with cellular assembly and organization, DNA replication and repair, tissue morphology, and cell-to-cell signaling. The gene expression profile was dependent on reversine concentration. In osteogenic media, cells pretreated with 300nM reversine exhibited an increased induction in alkaline phosphatase activity and enhanced expression of alkaline phosphatase, bone sialoprotein, osteocalcin, and ...
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification.. Main Body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue ...
Human Nucleus Pulposus Cell MicroRNA https://www.sciencepro.com.br/produtos/sc-4807 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
TY - JOUR. T1 - Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. AU - Kim, Hyang. AU - Lee, Jeong Uk. AU - Moon, Seong Hwan. AU - Kim, Hyung Chan. AU - Kwon, Un Hae. AU - Seol, Nam Hun. AU - Kim, Ho Joong. AU - Park, Jin Oh. AU - Chun, Heoung Jae. AU - Kwon, Il Keun. AU - Lee, Hwan Mo. PY - 2009/8. Y1 - 2009/8. N2 - Study Design.: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucleus pulposus (NP), transitional zone (TZ), and anulus fibrosus (AF) of the human intervertebral disc (IVD). Objective.: To demonstrate the differential effect of BMP-2 on DNA synthesis, proteoglycan synthesis, and osteocalcin mRNA expression in human IVD cells from the NP, TZ, and AF, respectively. Summary of Background Data.: BMP-2 has been proven to be effective in stimulating proteoglycan synthesis in articular chondrocytes and IVD cells from the NP. Nevertheless, the effect of BMP-2 on cells from different regions of the IVD has not yet been ...
The intervertebral disc (IVD) is one of the bodys most important load-bearing structures with the major mechanical force experienced in the nucleus pulposus (NP) being hydrostatic pressure (HP). Physiological levels of HP have an anabolic effect on IVD matrix metabolism in cells derived from non-degenerate animal and herniated IVD while excessive HP has a catabolic effect. However, no studies have investigated the response of non-degenerate and degenerate human disc cells derived from non-herniated discs to HP. Here we investigate the effect of physiological HP on such cells using a novel loading rig. Human IVD cells (both NP and AF) cultured in alginate were subjected to dynamic HP (0.8-1.7 MPa 0.5 Hz) for 2 h. Cell viability was assessed, RNA extracted and qRT-PCR for 18 s, c-fos, Sox-9, collagen type II, aggrecan and MMP-3 performed. Cell viability was unaffected by the loading regime. In non-degenerate NP cells, HP increased c-fos, aggrecan, Sox-9 and collagen type II (significantly so in ...
STUDY DESIGN: Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6, prostaglandin E2, and matrix metalloproteinases. The effects of endogenously produced nitric oxide on the synthesis of other mediators also were studied.. OBJECTIVES: To test the hypothesis that the cells of the intervertebral disc are metabolically active and are capable of responding to biochemical stimuli such as interleukin-1 beta in a manner that could engender degenerative changes. As part of this study, the authors also investigated some of the possible autocrine regulatory mechanisms that may operate during the biochemical responses of disc cells.. SUMMARY OF BACKGROUND DATA: The authors previously showed, for the first time, that herniated cervical and lumbar disc specimens spontaneously produce increased amounts of nitric oxide, interleukin-6, prostaglandin E2, and certain matrix metalloproteinases. These ...
The present disclosure is directed to methods for relieving pain associated with an intervertebral disc having a disc nucleus pulposus and an outer annulus fibrosus surrounding the nucleus pulposus. The method includes the steps of providing an elongated thermal or electromagnetic probe member having a flexible guidable region adjacent the distal end thereof; introducing the flexible guidable region of the probe into the annulus fibrosus of the intervertebral disc; and supplying thermal or electromagnetic energy, from an energy source, to heat or induce an electromagnetic field adjacent to the annulus fibrosus sufficient to produce a thermal or electromagnetic effect on the intervertebral disc. The flexible guidable region of the probe may be introduced at a location which is in relative close proximity to the region of intervertebral disc to be thermally or electromagnetically treated.
Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease process are still not well understood. In this study, we sought to determine whether MMP-2 is associated with degenerative changes in the AF and to identify the manner by which AF cells use MMP-2. Two established animal models of disc degeneration, static compression and transannular needle puncture of rodent caudal discs, were examined for MMP-2 immunopositivity. With lentiviral transduction of an shRNA expression cassette, we screened and identified an effective shRNA sequence for generating stable RNA interference to silence MMP-2 expression in primary rat AF cells. Gelatin films were used to compare gelatinase activity and spatial patterns of degradation between transduced cells, and both
TY - JOUR. T1 - Tissue engineering of the intervertebral disc with cultured nucleus pulposus cells using atelocollagen scaffold and growth factors. AU - Lee, Kwang Il. AU - Moon, Seong Hwan. AU - Kim, Hyang. AU - Kwon, Un Hye. AU - Kim, Ho Joong. AU - Park, Si Nae. AU - Suh, Hwal. AU - Lee, Hwan Mo. AU - Kim, Hak Sun. AU - Chun, Heoung Jae. AU - Kwon, Il Keun. AU - Jang, Ju Woong. PY - 2012/3/15. Y1 - 2012/3/15. N2 - Study Design.: In vitro experiment using rabbit nucleus pulposus (NP) cells seeded in atelocollagen scaffolds under the stimulation of growth factors. Objective.: To demonstrate the effect of anabolic growth factors in rabbit NP cells cultured in atelocollagen type I and type II. Summary of Background Data.: Atelocollagen provides intervertebral disc (IVD) cells for a biocompatible environment to produce extracellular matrix. IVD cells with exogenous transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2) also render an increase in matrix synthesis. ...
To read the full abstract subscribe to the JCM online archive.. Clinical effects of acupuncture following surgery in patients with prolapse of lumbar intervertebral disc, by Zhao Bin‑xiu et al. Prolapse of the lumbar intervertebral discs is clinically common. The ... SKU: a1145. ...
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks. Viability of native NP cells and delivered MSCs was maintained. Furthermore hMSCs delivered via the L-pNIPAM-co-DMAc hydrogel differentiated and produced NP matrix components: aggrecan, collagen type II and chondroitin sulphate, with integration of the hydrogel with native NP tissue. In addition L-pNIPAM-co-DMAc hydrogel injected into ...
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration. Here we identify populations of progenitor cells that are Tie2 positive (Tie2+) and disialoganglioside 2 positive (GD2+), in the nucleus pulposus from mice and humans. These cells form spheroid colonies that express type II collagen and aggrecan. They are clonally multipotent and differentiated into mesenchymal lineages and induced reorganization of nucleus pulposus tissue when transplanted into non-obese diabetic/severe combined immunodeficient mice. The frequency of Tie2+ cells in tissues from patients decreases markedly with age and degeneration of the intervertebral disc, suggesting exhaustion of their capacity for regeneration. However, progenitor cells (Tie2+GD2+) can be induced from their precursor cells (Tie2+GD2-) under simple culture conditions. Moreover, angiopoietin-1, a ligand of Tie2, is
TY - JOUR. T1 - ATP promotes extracellular matrix biosynthesis of intervertebral disc cells. AU - Gonzales, Silvia. AU - Wang, Chong. AU - Levene, Howard. AU - Cheung, Herman S.. AU - Huang, Chun Yuh Charles. N1 - Publisher Copyright: © 2014, Springer-Verlag Berlin Heidelberg.. PY - 2015/2. Y1 - 2015/2. N2 - We have recently found a high accumulation of extracellular adenosine triphosphate (ATP) in the center of healthy porcine intervertebral discs (IVD). Since ATP is a powerful extracellular signaling molecule, extracellular ATP accumulation might regulate biological activities in the IVD. The objective of this study was therefore to investigate the effects of extracellular ATP on the extracellular matrix (ECM) biosynthesis of porcine IVD cells isolated from two distinct anatomical regions: the annulus fibrosus (AF) and nucleus pulposus (NP). ATP treatment significantly promotes ECM deposition and corresponding gene expression (aggrecan and type II collagen) by both cell types in ...
The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. The methods comprise introducing an amount of the polyelectrolyte materials into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material.
Although histopathological grading systems for disc degeneration are frequently used in research, they are not yet integrated into daily care routine pathology of surgical samples. Therefore, data on histopathological changes in surgically excised disc material and their correlation to clinical parameters such as age, gender or body mass index (BMI) is limited to date. The current study was designed to correlate major physico-clinical parameters from a population of orthopaedic spine center patients (gender, age and BMI) with a quantitative histologic degeneration score (HDS). Excised lumbar disc material from 854 patients (529 men/325 women/mean age 56 (15-96) yrs.) was graded based on a previously validated histologic degeneration score (HDS) in a cohort of surgical disc samples that had been obtained for the treatment of either disc herniation or discogenic back pain. Cases with obvious inflammation, tumor formation or congenital disc pathology were excluded. The degree of histological changes was
K.Kato, S.Kitagava. Sapporo Higashi Tokushukai Hospital. Introduction. Surgical interventions on spine concerning hernias of intervertebral disks are one of the most spread interventions in neurosurgery. NLS may become one of the leading methods in diagnostics of intervertebral hernias and evaluation of their treatment effectiveness by surgical methods. Failure rate after herniated disks surgeries with progression of «failed» intervention syndrome is registered not less than in 10-40% cases. Some researchers believe that absence of effect in case of spinal surgery is registered not less than in 25% of cases. NLS-method allows obtaining reliable and visual images of vertebral bodies, spinal canal, intervertebral discs, ligamentous apparatus and soft tissues; it also reveals all changes in surgery area and shows reasons that caused unsuccessful treatment of disc herniation.. The purpose of given study was clarifying lumbar spine condition after operative treatment of intervertebral hernias ...
METHODS: The gene expression profiles data were obtained using the same microarray platform for two groups of patients suffering from degenerative disc diseases: GSE41883 (Human annulus disc cells exposed to TNF-a; 4 samples) and GSE27494 (Human annulus disc cells exposed to IL-1β; 4 samples). The genes that were differentially expressed in these two datasets compared to control disc cells (without cytokine exposure; 4 samples each) were identified using the R language, and were pooled using the Excel software program to select the common differentially expressed genes in the two datasets. The initial functional clustering, signaling pathways and protein-protein interaction relationship analyses were conducted using the DAVID and STRING software programs ...
Objective: This study was designed to assess the prognoses of different lumbar intervertebral disc pathologies on foot drop. Patients and Methods: We retrospectively eval..
Background: Dysregulation of microRNAs (miRNAs) has been reported to be associated with Intervertebral Disc Degeneration (IDD), and accumulating evide..
TY - JOUR. T1 - Multiphasic finite element analysis of physical signals and solute transport in the human intervertebral disc. AU - Yao, Hai. AU - Gu, Wei Yong. PY - 2004/1/1. Y1 - 2004/1/1. UR - http://www.scopus.com/inward/record.url?scp=20444477875&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=20444477875&partnerID=8YFLogxK. U2 - 10.1115/imece2004-59837. DO - 10.1115/imece2004-59837. M3 - Conference article. AN - SCOPUS:20444477875. SP - 393. EP - 394. JO - Advances in Bioengineering, BED. JF - Advances in Bioengineering, BED. SN - 0360-9960. M1 - IMECE2004-59837. T2 - 2004 ASME International Mechanical Engineering Congress and Exposition, IMECE. Y2 - 13 November 2004 through 19 November 2004. ER - ...
Researchers looked specifically at the intervertebral disc, which contains three integrated structures: the inner gelatinous nucleus pulposus (NP), the outer lamellar annulus fibrosus (AF) and the cartilaginous endplates (EP) that connect the invertebral discs to the vertebral bodies. A healthy intervertebral disc is considered immune privileged, and the disc-in particular the AF-acts as a physical and biochemical barrier to inflammation and immune cell infiltration. However, during aging, degeneration and/or injury, mast cells can enter the intervertebral disc. Although scientists have documented the presence of mast cells in painful discs, the role of mast cells in low back pain and intervertebral disc degeneration is still not well understood.. Recent research published online on Oct. 2 in Scientific Reports revealed that mast cells can infiltrate intervertebral disc cells and play a key role in their degeneration.1 The investigators designed their study to better understand the presence and ...
Methods of securing an implant within an intervertebral disc are provided. In some embodiments, systems for minimally invasive disc augmentation include an anulus augmentation component and a nucleus augmentation component. Both are suited for minimally invasive deployment. The nucleus augmentation component restores disc height and/or replaces missing nucleus pulposus. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed. Methods of closing a defect in an anulus fibrosus of an intervertebral disc using a barrier are also provided.
This 3D medical animation depicts the anatomy of the cervical spine and a typical intervertebral disc from C3 through C7. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disc and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
Question - MRI shows intervertebral disc space. How much does this affect lower back pain? . Ask a Doctor about when and why MRI is advised, Ask an Orthopaedic Surgeon
Assessment of the Possibilities of B-Mode Ultrasonography in the Diagnosis of Cervical Intervertebral Discs Hernia in Adolescents
TY - JOUR. T1 - Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load. T2 - A caprine in vitro study. AU - Emanuel, Kaj S.. AU - van der Veen, Albert J.. AU - Rustenburg, Christine M.E.. AU - Smit, Theodoor H.. AU - Kingma, Idsart. PY - 2018/3/21. Y1 - 2018/3/21. N2 - The mechanical behaviour of the intervertebral disc highly depends on the content and transport of interstitial fluid. It is unknown, however, to what extent the time-dependent behaviour can be attributed to osmosis. Here we investigate the effect of both mechanical and osmotic loading on water content, nucleus pressure and disc height. Eight goat intervertebral discs, immersed in physiological saline, were subjected to a compressive force with a pressure needle inserted in the nucleus. The loading protocol was: 10N (6h); 150N (42h); 10N (24h). Half-way the 150N-phase (24h), we eliminated the osmotic gradient by adding 26% poly-ethylene glycol to the surrounding ...
Instrument and method for removing material from an intervertebral disc. The instrument includes outer and inner tubular members. The outer tubular member defines a passage and a cutting window. The inner tubular member is coaxially disposed within the passage, and defines a central lumen and a cutting tip. The cutting tip forms an open mouth having a plurality of teeth. Upon assembly, the cutting tip is exposed within the cutting window combining to define a shaving head. A powered handpiece is coupled to the inner tubular member, and the shaving head is inserted into an intervertebral disc and positioned such that the cutting tip contacts targeted material (e.g., nucleus, annulus and/or end plate). The handpiece is activated to rotate the cutting tip relative to the cutting window. Contacted material is sheared between an edge of the cutting window and the teeth of the cutting tip.
Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.
Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.
1. Dagenais S, Caro J, Haldeman S. A systematic review of low back pain cost of illness studies in the United States and internationally. The spine journal: official journal of the North American Spine Society. 2008;8:8-20 2. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine. 2000;25:487-92 3. Adams MA, Freeman BJ, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine. 2000;25:1625-36 4. Hee HT, Zhang J, Wong HK. An in vitro study of dynamic cyclic compressive stress on human inner annulus fibrosus and nucleus pulposus cells. Spine J. 2010;10:795-801 5. Fernando HN, Czamanski J, Yuan TY, Gu W, Salahadin A, Huang CY. Mechanical loading affects the energy metabolism of intervertebral disc cells. Journal of orthopaedic research: official publication of the Orthopaedic Research Society. 2011;29:1634-41 6. Wang DL, Jiang SD, Dai LY. Biologic response of the ...
Attention!!! Dear Sir or Madam! I would like to inform you of unbelievable efficacy and simplicity of protuberance or herniated pultaceous intervertebral discs repair, which can be monitored by means of magnetic resonance imaging (more). It is important to know that each nerve cell in the nervous system of animal organisms (possibly including plants) has its structural and functional memory, functional in terms of neurophysiology, needed for immanent regulation of bio cybernetic functions, among others to maintain the shape of pultaceous intervertebral discs.. Attention! If objective diagnosis reveals proturbernce or herniated pultaceous intervertebral discs even with compression on the dural sac with pain stenosis. in such case it is advisable to hold skewers between your fingers (choose the sharpest ones), and perpendicularly to the skin perform auto stimulation, triggering stimulus by means of special spatulas which are 7 centimetres wide, beginning with the adams bone, then moving down to ...
The intervertebral disc is one of the most common sources of low back pain. Intervertebral discs are structures in between the lumbar vertebrae that act as shock absorbers for the spine. They help aid trunk motion, transmit loads from one vertebral body to the next, and help protect various structures in the low back such as the lumbar vertebrae and nerve roots. The intervertebral disc is made up of two parts, the annulus fibrosus and the nucleus pulposus. The nucleus pulposus contains a gel made primarily of water and proteoglycans and acts to resist axial compression and distribute compressive forces. The annulus fibrosus is made primarily of collagen fibers and encloses the nucleus pulposus; which helps withstand tension within the disc. There are several theories as to the source of pain generation in a disc injury involving an intervertebral disc that is either degenerative or herniated. Mechanical compression and an inflammatory response is one hypothesis to explain pain from a disc ...
This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
Magnetic Resonance Imaging Follow-up Study on Two Cases of Lumbar intervertebral Disc Sequestration Patients Treated with Oriental Medicine Treatment;kpubs;kpubs.org
Acupuncture for the syndrome of prolapsed lumbar Intervertebral disc --Case studies and clinical experiences By Dr. Yin Hongchun Tel: Main point of diagnosis (1)
The book the lumbar intervertebral disc has not reserved. capable referral can sign from the late. If same, completely the & in its reflective excess.
1970 Dec 12;87(24):737-41. 34. Chang Y, Dennis R, Platt SR, Penderis J. Magnetic resonance imaging of traumatic intervertebral disc extrusion in dogs. Vet Rec. 2007 Jun 9;160(23):795-9. 35. Hansen HJ. A pathologic-anatomical interpretation of disc degeneration in dogs. Acta Orthop Scand. 1951;20(4):280-93. 36. Olsson SE, Hansen HJ. Cervical disc protrusions in the dog. J Am Vet Med Assoc. 1952 Nov;121(908):361-70. 37. Olsson SE. On disc protrusion in dog (enchondrosis intervertebralis); study with special reference to roentgen diagnosis and to the value of disc fenestration. 1) [20]. Contrary to the well-innervated human IVDs [28], the innervation of the canine IVD tissue itself is sparse: nerve endings have only been found in the outer lamellae of the AF and not in the NP, the transitional zone, or the inner AF [29-31]. However, soft tissue structures surrounding the canine IVDs, such as the dorsal longitudinal ligament, are profusely innervated [29, 30]. 06 Gross pathology a N/A a N/A ...
Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleus pulposus cells. The local administration of platelet-rich plasma might stimulate intervertebral disc repair. In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues ...
Background Low back pain (LBP) may be the leading global reason behind disability and it is connected with intervertebral disc degeneration (DD) in a few individuals. and examined by multiplex cytokine assay. Interleukin-8 (IL-8) manifestation was verified by ELISA in CSF and in intervertebral discs. The SPARC-null mouse style of intensifying, age-dependent DD and persistent LBP was useful for pre-clinical validation. Man SPARC-null and control mice received systemic Reparixin, a CXCR1/2 (receptors for IL-8 and murine analogues) inhibitor, for 8?weeks. Behavioral signals of axial radiating and discomfort pain were assessed. Pursuing completion of the study, discs were excised and cultured, and conditioned media was evaluated with a protein array. Findings IL-8 was elevated in CSF of chronic LBP patients with DD compared to pain-free subjects with or without DD. Chronic inhibition with reparixin alleviated AZD-5991 S-enantiomer low back pain behaviors and attenuated disc inflammation in ...
Looking for information on Cervical Artificial Disc Replacement in Aztec? We have compiled a list of businesses and services around Aztec that should help you with your search. We hope this page helps you find information on Cervical Artificial Disc Replacement in Aztec.
Looking for information on Cervical Artificial Disc Replacement in Rio Rancho? We have compiled a list of businesses and services around Rio Rancho that should help you with your search. We hope this page helps you find information on Cervical Artificial Disc Replacement in Rio Rancho.
STUDY DESIGN: The progression of intervertebral disc degeneration (IDD) follows anterolateral stab of adult rabbit lumbar discs by 16-gauge hypodermic needle to a limited (5-mm) depth was studied for up to 24 weeks using magnetic resonance imaging (MRI).OBJECTIVES: To develop a slowly progressive, reproducible rabbit model of IDD suitable for studying pathogenesis and pathopysiology of intervertebral disc degeneration. Moreover, to improve the MRI methods and achieve improved MRIs a custom quad coil tuned and matched for 3.0T was developed. Higher SNR achievable with this coil allowed the acquisition of higher resolution images.METHODS: Part1 - The L2-L3, L3-L4, and L4-L5 lumbar intervertebral discs of 18 skeletally mature female New Zealand White (NZW) rabbits were stabbed by 16-gauge hypodermic needle to a depth of 5-mm in the left anterolateral annulus fibrosis (AF). Serial MRI scans of the stabbed discs and intact L1-2 and L5-6 control discs were performed at 3, 6, 12, and 24 weeks post ...
OBJECTIVE: To study the pathogenesis of the pain of discography and the discogenic low back pain.. METHODS: 19 specimens of lumbar intervertebral discs from 17 patients with discogenic low back pain during posterior lumbar interbody fusion, and 12 physiologically aging discs and 10 normal control discs were collected to investigate the morphologic features and innervation containing neuropeptides substance P (SP), neural filament (NF), and vasoactive-intestinal peptide (VIP).. RESULTS: The distinct morphologic characteristic of the disc from the patient with discogenic low back pain was the formation of the strip zone of vascularized granulation tissue from the nucleus pulposus to the outer part of the annulus fibrosus in which there was one or several fissures. The structure of annulus fibrosus beyond the strip zone of granulation tissue was basically normal. The structures of the aging discs and the control discs showed the age-related changes. The innervation of SP, NF and VIP immunoreactive ...
Fingerprint Dive into the research topics of Potential association of metabolic and musculoskeletal disorders with lumbar intervertebral disc degeneration: Cross-sectional study using medical checkup data. Together they form a unique fingerprint. ...
BACKGROUND CONTEXT Osteoporosis adversely affects disc degeneration cascades, and prophylactic alendronate (ALN) helps delay intervertebral disc degeneration (IDD) in ovariectomized (OVX) rats. However, there remains no information regarding whether ALN affects IDD with bone loss. PURPOSE This study aimed to observe the effects of ALN on degenerative discs with bone loss induced by OVX in rats. STUDY DESIGN This study used controlled in vivo experiments in rodents. METHODS Thirty female Sprague-Dawley rats were randomly assigned to undergo sham surgery (n=10) or OVX surgery (n=20); 3 months later, the OVX animals were injected with either ALN (OVX+ALN, 15 µg/kg/2w, n=10) or normal saline (OVX+vehicle treatment [V], n=10). At 3 months after the ALN intervention, van Gieson staining and immunohistochemistry were used to investigate histologic and metabolic changes in the discs. Bone mineral density (BMD), micro-computed tomography, and biomechanical tests were conducted to determine the biological
Low back pain (LBP) can significantly reduce the quality of life of patients, and has a considerable economic and social impact worldwide. It is commonly associated with disc degeneration, even though many people with degenerate discs are asymptomatic. Degenerate disc disease (DDD), is thus a common term for intervertebral disc (IVD) degeneration associated with LBP. Degeneration is thought to lead to LBP because of nerve ingrowth into the degenerate disc, inflammation, or because degradation of extracellular matrix (ECM) alters spinal biomechanics inappropriately. Thus, while the objectives of some interventions for LBP are to control pain intensity, other interventions aim to deal with the consequences of disc degeneration through stabilizing the disc surgically, by inserting artificial discs or by repairing the disc biologically and preventing progressive IVD degeneration. Despite tremendous research efforts, treatment of LBP through the use of regenerative interventions aiming to repair the IVD is
In this study, we showed that people with an Sp1 polymorphism of the COLIA1 gene had an increased risk of intervertebral disc degeneration. In addition, we examined the association between COLIA1 Sp1 polymorphism and osteoporosis. Although, our results indicate that male carriers of the T allele had higher levels of serum OC, the COLIA1 Sp1 polymorphism did not seem to be related to any other indicator of male osteoporosis. In women, none of the outcome measures of osteoporosis was found to be associated with this studied polymorphism.. Although several recent studies have focused on the association of the COLIA1 Sp1 polymorphism with osteoporosis, until now not much attention has been given to the relation of this genotype with disc degeneration. As far as we know this is the first study to have demonstrated an association between the COLIA1 Sp1 polymorphism and an increased risk of disc degeneration. Although the number of respondents with disc degeneration in this sample is relatively small, ...
Objective: to evaluate plasma vitamin D and cross-linked C-telopeptides of type I (CTx-I) and type II (CTx-II) collagen concentrations in males with lumbar intervertebral disc degeneration (IVD) compared to healthy controls. Improved knowledge might suggest to optimize the vitamin D status of IVD patients and contribute to clarify mechanisms of cartilage degradation. Methods: 79 Italian males with lumbar IVD assessed by Magnetic Resonance Imaging (MRI) and 79 age, sex and BMI-matched healthy controls were enrolled. Plasma 25hydroxyvitamin D (25(OH)D), CTx-I and CTx-II were measured by immunoassays. Circannual seasonality, correlation between biomarkers concentrations and clinical variables were assessed. Results: overall subjects 25(OH)D and CTx-II showed month rhythmicity with acrophase in August/September and October/November, and nadir in February/March and April/May, respectively. An inverse correlation between 25(OH)D and CTx-I, and a direct correlation between CTx-II and CTx-I were ...
Currently, herniated nucleus pulposus (HNP) with radiculopathy and other preconditions are regarded as relative or absolute contraindications for lumbar total disc replacement (TDR). In Switzerland it is left to the surgeons discretion when to operate. The present study is based on the dataset of SWISSspine, a governmentally mandated health technology assessment registry. We hypothesized that preoperative nucleus pulposus status and presence or absence of radiculopathy has an influence on clinical outcomes in patients treated with mono-segmental lumbar TDR. Between March 2005 and April 2009, 416 patients underwent mono-segmental lumbar TDR, which was documented in a prospective observational multicenter mode. The data collection consisted of perioperative and follow-up data (physician based) and clinical outcomes (NASS, EQ-5D). Patients were divided into four groups according to their preoperative status: 1) group degenerative disc disease (DDD): 160 patients without HNP and no radiculopathy, classic
Currently, herniated nucleus pulposus (HNP) with radiculopathy and other preconditions are regarded as relative or absolute contraindications for lumbar total disc replacement (TDR). In Switzerland it is left to the surgeons discretion when to operate. The present study is based on the dataset of SWISSspine, a governmentally mandated health technology assessment registry. We hypothesized that preoperative nucleus pulposus status and presence or absence of radiculopathy has an influence on clinical outcomes in patients treated with mono-segmental lumbar TDR. Between March 2005 and April 2009, 416 patients underwent mono-segmental lumbar TDR, which was documented in a prospective observational multicenter mode. The data collection consisted of perioperative and follow-up data (physician based) and clinical outcomes (NASS, EQ-5D). Patients were divided into four groups according to their preoperative status: 1) group degenerative disc disease (DDD): 160 patients without HNP and no radiculopathy, classic
Introduction: MiR-202-3p is involved in the pathogenesis of intervertebral disc degeneration (IDD) via regulating MMP-1 expression in neuronal precursor cells (NPCs). As an activator of miR-202-3p and KDM6A expression, metformin (MET) may regulate the expression of SOX9 via regulating the...
Intervertebral disc herniation (IVDH) involves displacement of the intervertebral disc secondary to disc degeneration and is extremely common in dachshunds. Clinical signs include pain with or without paresis or paralysis. Mortality rate is high and some cases are left with permanent disability even after treatment. Aims of this study were twofold: Firstly, to investigate whether neutering, i.e. gonadectomy, is associated with increased risk of IVDH in dachshunds, and secondly to investigate whether age of neutering alters risk of IVDH in this breed. Information was obtained for 1964 dachshunds from the owner survey,
Dr Uday Doctor in Pearland, Beaumont and Houston, TX offers lumbar facetectomy or foraminotomy. He treats obstructed neuroforamen, bone spurs and herniated intervertebral disc.
A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.
With degenerative disc disease, the main problem lies within one or more of the intervertebral discs. There is a disc between each of the vertebra in your spine. The intervertebral discs are designed to absorb pressure and keep the spine flexible by acting as cushions during body movement. The discs are similar to shock absorbers. Without the cushion effect of the discs, the vertebrae in your spine would not be able to absorb stresses, or provide the movement needed to bend and twist. Bones cannot sustain high stress repeatedly without being damaged. Much of the mechanical stress of everyday movements is transferred to the discs.. A healthy intervertebral disc has a great deal of water in the nucleus pulposus - the center portion of the disc. The water content gives the nucleus a spongy quality and allows it to absorb spinal stress. Excessive pressure or injuries to the disc can cause the injury to the annulus - the outer ring of tough ligament material that holds the vertebrae together. ...
This study examined the ability of the extreme lateral interbody fusion (XLIF) procedure to restore coronal and sagittal alignments for patients with adult spinal deformity (ASD) using computed tomography multiplanar reconstruction (CT-MPR). Thirty-eight patients with ASD undergoing correction and fixation with XLIF at 114 levels were studied. The coronal segmental Cobb angle, coronal regional Cobb angle (L1-5), sagittal segmental Cobb angle, sagittal regional Cobb angle (L1-5), intervertebral disc height and, vertebral body rotation (VBR) were measured before and after of XLIF surgery using CT-MPR. The mean sagittal segmental Cobb angle, the coronal segmental Cobb angle and VBR were corrected from 5.0° to 9.0°, from 6.3° to 4.3° and from 12.2° to 10.8°, respectively. The mean of the intervertebral disc heights increased significantly from 6.0 mm to 10.4 mm postoperatively. Although increases in coronal segmental Cobb, sagittal segmental Cobb, and intervertebral disc height at each level were
Lumbar total disc replacement surgery in Korea can be a cost saving option for people who are not able to pay for it in their own country. Medical Tourism Co is offering pre-screened quality healthcare facilities for artificial disc replacement surgery in Korea.. Please submit quote request form on right for price estimate.. ...
Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation.
Objective: To determine efficacy of radionucleoplasty infiltration in intervertebral disc herniation Background of Background Data: Radionucleoplasty is a new, minimally invasive procedure for the treatment of disc prolapse. The aim of the present study was to determine associations between the morphology of the basic disease, patient-specific factors and the outcome of the treatment.Disc prolapse is one of the important causes of low back pain radiating to limbs. Apart from conservative therapy all other forms of treatment aim at decompressing the nerve roots. These can be done by taking the disc out by surgery or by decompressing the foramen and disc by different interventions. The various treatment options have confused clinicians due to significant failure rate associated with different kinds of surgeries as well as with different interventions. Injecting a thermal wand fordisc prolapsehas developed as an alternative to chemonucleolysis and disc surgery owing to its high success rates, less ...
Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleuspulposus cells. The local administration of platelet-rich plasma might stimulate intervertebral disc repair. In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (Akeda et al Spine 2006 ...
Replacement of Spinal Disc surgery is also popularly known as intervertebral disc athroplasty or total disc replacement. This process involves the spine getting replace with artificial made like metal or plastic ones both in the upper or lower spine. This surgery is done to treat chronic and severe cervical and lumbar pain which results from DDD or Degenerative Disc Disorder.. This procedure is a new one for several types of lumbar pain. Just recently this process is approved by FDA in the United States and research is ongoing worldwide especially in Europe. This might become a standard cure for some lower back pains.. Artificial disc replacement surgery is done to remove and lessen pain while promoting flexibility in the spine. Those who are qualified to have spinal disc replacement surgery are the following;. ...
Science & Technology, Life Sciences & Biomedicine, Biochemical Research Methods, Biochemistry & Molecular Biology, Mesenchymal stem cell (MSC), Regenerative medicine, Tissue engineering, Low back pain (LBP), Intervertebral disc (IVD), IVD degeneration, Biological therapy, Cellular therapy, Articular cartilage, Osteoarthritis (OA), Umbilical cord, Whartons Jelly stem cell (WJSC), Adipose-derived stem cell (AD-MSC), HUMAN UMBILICAL-CORD, LOW-BACK-PAIN, NECROSIS-FACTOR-ALPHA, PLATELET-RICH PLASMA, PULPOSUS-LIKE CELLS, IN-VITRO, NUCLEUS PULPOSUS, PROGENITOR CELLS, STROMAL CELLS, LUMBAR DISC ...
Degeneration of the intervertebral discs is a normal part of aging. However, in some patients, disc degeneration occurs early or more severely than is normal. In some cases, the degeneration of the intervertebral discs can lead to severe, chronic pain.. Degenerative disc disease can manifest as various symptoms. It is a common misconception that only the elderly are affected by DDD. However, this is not the case; DDD can affect younger individuals as a result of injury or other variables. In many patients suffering from degenerative disc disease, the pain is reported as a pins and needles type of sensation. The pain can be exacerbated by daily activities such as sitting down, bending, or reaching. Any dull, aching pain that is localized in the lower back requires the attention of a physician at the soonest available time. In the event that an appointment isnt immediately available, DDD patients often experience relief when they lay down in the prone or supine positions. This position ...
TY - JOUR. T1 - Effect of intradiscal electrothermal treatment with a short heating catheter and fibrin on discogenic low back pain. AU - Derby, Richard. AU - Kim, Byung Jo. PY - 2005/7. Y1 - 2005/7. UR - http://www.scopus.com/inward/record.url?scp=20544467947&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=20544467947&partnerID=8YFLogxK. U2 - 10.1097/01.phm.0000167619.84014.fb. DO - 10.1097/01.phm.0000167619.84014.fb. M3 - Article. C2 - 15973093. AN - SCOPUS:20544467947. VL - 84. SP - 560. EP - 561. JO - American Journal of Physical Medicine and Rehabilitation. JF - American Journal of Physical Medicine and Rehabilitation. SN - 0894-9115. IS - 7. ER - ...
Degenerative disc disease (DDD) describes the natural breakdown of anintervertebral disc of the spine. Despite its name, DDD is not considered a disease, nor is it progressively degenerative. On the contrary, disc degeneration is often the effect of natural daily stresses and minor injuries that cau
An intervertebral disk prosthesis system, which is used for forming an artificial intervertebral disk and comprises a first and a second prosthesis component wherein each of the two prosthesis components comprises a first and a second vertebral body contacting element for placement on neighboring vertebral bodies bounding an intervertebral disk space of a spinal column and a joint element that is mounted between and is moveable relative to at least one of the first and second vertebral body contacting elements, attains a substantially natural range of motion independent of the positioning of the two prosthesis components relative to each other and to the neighboring vertebral bodies. Each prosthesis component has a ball joint formed between the first and second vertebral body contacting elements.
Surgical options to reduce the pain of DDD include:. Discectomy: the surgical removal of herniated disc material that presses on a nerve root or the spinal cord. The procedure involves removing the central portion of an intervertebral disc, the nucleus pulposus, which causes pain by stressing the spinal cord or radiating nerves.. Laminectomy: surgery that creates space by removing the lamina - the back part of the vertebra that covers your spinal canal. Also known as decompression surgery, laminectomy enlarges your spinal canal to relieve pressure on the spinal cord or nerves.. Spinal fusion: a neurosurgical or orthopedic surgical technique that joins two or more vertebrae. This procedure can be performed at any level in the spine (cervical, thoracic, or lumbar) and prevents any movement between the fused vertebrae.. Lumbar Total Disc Replacement: With artificial disc replacement, pain relief is brought about by removal of the painful disc and motion is maintained with the use of a prosthetic ...
Discogenic low back pain remains a difficult lumbar syndrome to treat. Recently developed electro-thermal technology permits precise tissue temperature control, steerability, and controlled lesion production in collagenous tissue. This novel treatment permits targeted shrinkage of annular and nuclear disc collagen (collagen shrinkage has been reported in the literature) and may preserve disc function without tissue necrosis or the need for fusion. It may also be useful in the ablation of pain sensing nociceptors.. ...
Looking for online definition of passive physiologic intervertebral movements in the Medical Dictionary? passive physiologic intervertebral movements explanation free. What is passive physiologic intervertebral movements? Meaning of passive physiologic intervertebral movements medical term. What does passive physiologic intervertebral movements mean?
There are 3 main types of disc injuries. The first disc injury consists of annular fiber tears which do not extend to the outer aspects of the disc. Thus, the inner nuclear material is prevented from completely escaping the disc. The second type of disc injury, commonly referred to as a disc herniation, consists of annular tears which run from the innermost aspects of the annulus (where the nucleus is) to the outermost aspects of the annulus. In this type of injury, the pressurized nuclear material can squeeze through the tears in the annulus and escape to the outside of the disc. When this occurs, the nuclear material may come in contact with nearby spinal nerves and even the spinal cord. In the third type of disc injury, referred to as a disc bulge, the inner nucleus loses hydration; common in those with prolonged spinal stress and the elderly. This results in bulging of the disc much like a tire bulges when it contains inadequate amounts of air. Similar to the previous injury, the nearby ...
While a single-level fusion is in and of itself a major surgery, a multi-level fusion has significantly more potential risks and complications associated with it and should be considered only in rare instances.. While it is a major surgery, fusion surgery can be an effective option for patients to enhance their activity level and overall quality of life. This potential positive outcome is particularly true now that less invasive surgical techniques are available to decrease post-operative discomfort, preserve more of the normal anatomy of the low back, and result in higher rates of fusion than previous techniques.. Lumbar Artificial Disc Replacement Surgery. A newer surgery to treat pain and disability from lumbar degenerative disc disease is artificial disc replacement. The theory is that replacing the disc, instead of fusing the disc space together, maintains more of the normal motion in the lumbar spine, thereby reducing the chance that adjacent levels of the spine will break down due to ...
Degenerative disc disease causes low back pain in two different ways. First, the nerve roots can be pinched as a direct result of degenerative disc disease. A nerve root exits the spinal canal through a small hole called the foramen. The height of the foramen is determined, to a great degree, by the height of the disc. When discs degenerate, they lose height. As a result, when discs degenerate, the foramen loses height. If the space for the nerve root in the foramen gets tight enough the nerve root and become pinched and painful. When this occurs you feel leg pain more than back pain.. Degenerative disc disease can also cause back pain itself. The reason is a little bit complicated. The disc is composed of two parts: a very tough outer part, and an inner gel. Because the inner part of the disc is made out of a gel, it does not have its own blood supply. (Fun fact, the disc is the largest structure in the human body that does not have its own blood supply.) The way your body knows what is part of ...
Is degenerative disc disease work related, even if it results in low back surgery and permanent work restrictions? This second part blog continues the discussion of work-related degenerative disc disease. Yes, if a traumatic work accident caused the degeneration to accelerate beyond normal progression or if the degeneration itself was contributed to by your job duties over time. Your workers compensation attorney must have a sincere understanding of the medicine involving low back degenerative disc disease which can lead to low back disability, permanent work restrictions, and loss of earning capacity.. The nucleus may push through the torn annulus and into the spinal canal. This is called a herniated or ruptured disc. The disc material that squeezes out can press against the spinal nerves. The disc also emits enzymes and chemicals that produce inflammation. The combination of pressure on the nerves and inflammation caused by the chemicals released from the disc cause pain.. As the degeneration ...
Degenerative disc disease is one of the most common causes of low back pain, yet can also be one of the most misunderstood and difficult to diagnose. It is the single most common diagnosis related to serious back pain and neck pain, and tends to occur more frequently with age. As a person ages, the discs can become brittle, susceptible to hemiation, and all together less durable. The main causes of degenerative disc disease are age, family history, lifestyle and age. It is most often reported in patients over 35. Lifestyle is particularly important, individuals who frequently lift heavy items may expose their spine to trauma. Repetitive shock can also promote the development of degenerative discs over time. Degenerative disc disease can be a confusing diagnosis for many patients, and mainly due to the terms Degenerative and Disease, as it is not strictly degenerative or progressive, and it is not really a disease, but rather a condition that produces pain caused by the damaged disc. ...
Interventional Spine announced FDA clearance of its Lateral Opticage Expandable Intervertebral Body Fusion Device. This device joins the Interventional Spine family of Opticage Expandable Interbody Fusion Devices previously cleared for TLIF earlier this year, and used with the Companys PerX360 System.. The Opticage Expandable Intervertebral Body Fusion Device is a lumbar intervertebral body fusion device and is indicated for use with autogenous bone graft in patients with degenerative disc disease (DDD) at one or two contiguous levels from L2-S1. The Opticage Expandable Interbody Fusion Device can be implanted via posterior, transforaminal or lateral approach.. Mr. Walter A. Cuevas, Chief Executive Officer of Interventional Spine said: With this milestone, Interventional Spine continues to lead the spine market in providing the most innovative solutions for surgeons, which in the end, benefit patients. This new indication for the Opticage Expandable Interbody Fusion Devices broadens the ...
Back pain is a common complaint and the origin of this frequently attributed to degenerative disc disease. In the most severe cases, the integrity of the disc and surrounding tissue is lost to such an extent that surgical intervention is necessary. Fusion procedures are commonly used to treat severely degenerated discs. Yet this is known to alter the biomechanics of the operated level, and may create a progression of degenerative decline. Total disc replacement has emerged as a viable treatment but the complexity of the spine is reflected in the clinical results, which trail far behind the success of hip and knee arthroplasty. This may be due to a failure of total disc replacement procedures to restore the natural biomechanics of the spine. The present study has led to the development of a dynamic pre-clinical testing protocol to quantitatively assess the efficacy of disc replacement devices. A six-axis spine simulator was designed and built, and the stiffness matrix testing of porcine lumbar ...
Discectomy refers to the removal of total or a part of an intervertebral disc. Anterior cervical discectomy is a surgical procedure offered at Illinois Spine Institute in Crystal Lake, IL.
The research literature concerning disc degeneration is particularly diverse, and there are no accepted definitions to guide biomedical research, or medicolegal practice.
Deflection images of living outer Annulus cells from Bovine Intervertebral discs, day 6 (after seeding), imaged in culture medium containing 10% fetal bovine serum (FBS) using Contact Mode. Left image was acquired before a series of force curves were taken on the area of the cell that is circled in red. Right image was acquired 45 minutes later. Displayed force curve was acquired on the cell marked with an X. It can be clearly seen that the cells have moved, undergone cytoskeletal reorganization and, where the force curves were taken, were damaged by the AFM tip, 54µm.. Data Courtesy of Y. Dror and J. Klein, Oxford University and Weizmann Institute, NanoInteract consortium.. ...
Our neurosurgical team adopts the finest of spinal surgical practices for patient comfort. There are many artificial disc methods typically classified into two general types: total disc replacement and disc nucleus replacement. In a total disc replacement, all or most of the disc tissue is removed and a replacement device is implanted into the space between the vertebrae. With a disc nucleus replacement, only the center of the disc is removed and replaced with an implant. The outer part of the disc is not removed. By removing disc tissue and eliminating movement, the pain will be significantly reduced.. Complexities of artificial disc replacement ...
Purpose Abnormal stress in the lumbar vertebra, also known as bony stress, can be a precursor to degenerative changes which may manifest as low back pain (LBP). However, the prevalence of bony stress...
Twelve dogs were divided into two equal groups and given lumbar intradiscal injections of 10, 50, or 100 U/ml of chondroitinase ABC reconstituted in sodium acetate buffer. Radiographs of the lumbar spine were made before and after surgery in both groups. Additional films were made at 5 days after su …
Lumbar disc disease (LDD) is among the most common ailments in Western societies.1 In the military, LDD often results in significant impairments and contributes greatly to health care costs and disability.2 Military training often results in exacerbation or presentation of LDD related symptoms. LDD appears to be a multifactorial disorder in which genetics play an important role, as it is evident from several recent studies.3. Collagen is the most abundant structural component of the extracellular matrix. Changes in collagen cross linking have been identified in degenerative disc disease, and LDD was recently associated with a polymorphism of the collagen type IX (COL9A3) gene.3 Type I collagen is the major protein in skin, ligaments, and bone; both COL1A1 and COL1A2 are present in the main components of the intervertebral disc, the annulus fibrosus (primarily) and the nucleus pulposus (secondarily).4. A G→T polymorphism within the COL1A1 regulatory region that affects the recognition site for ...
Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Hypoxia and low pH stressed disc conditioned medium promotes hypersensitivity of peripheral sensory neurons. ORS PSRS 5th Symposium, Skytop PA (US), Nov 3-7, 2019 (poster). Stefanoska D, Ma J, Grad S, Alini M, Peroglio M. Effects of glucose concentration and pH on dorsal root ganglion neurite outgrowth. Pain in EU XI EFIC, Valencia (Spain), Sep 4-7, 2019 (e-poster). Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Effect of pH and oxygen tension on dorsal root ganglion calcium response to bradykinin and neurite sprouting. Pain in EU XI EFIC, Valencia (Spain), Sept 4-7, 2019 (poster). Ma J, Stefanoska D, Hildebrand M, Zeiter S, Alini M, Peroglio M. Validation of cell line models to study intervertebral disc neo-innervation associated with discogenic pain. Swiss 3R Day, Bern (CH), Sept 2, 2019 (poster).. Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Low pH culture of dorsal root ganglion cells as an in vitro model to study pathological changes ...
What is an intradiscal PRP injection and how can it help?. Injection of platelet rich plasma (PRP) is still considered an experimental treatment, although evidence for its effects are mounting. PRP can induce inflammation and healing in the tissue in which it is injected, and has beneficial effects in treating other painful conditions. Recent studies have shown there to be evidence that PRP may be beneficial in patients with degenerative disc disease. With the assumption that inflammation and degeneration are the cause of disc related pain, we inject a small amount of PRP into the nucleus pulposus of the intervertebral disc.. Approximately 40% of low back pain is thought to come from the intervertebral disc disease. As we age, or through trauma and accidents, the discs become damaged. As they become damaged, and through tears in their outer layers, they lose their functional integrity and hydration, leading to the in growth of pain sensing nerves. This is often referred to as discogenic ...
Degenerative disc disease info, Degenerative disc disease or DDD is a spinal condition caused by the breakdown of your intervertebral discs. Symptoms, causes, diagnosis, treatment options.
and cauda equina symptoms is disc height loss. As the disc wears there is loss of disc height and an increased likelihood of the ��� Learn more about the various symptoms and treatment options for Lumbar Degenerative Disc Disease from our spine specialists in NJ and NY. Discs act as natural shock absorbers in the spine, so when they are damaged, it can cause pain. Nonsurgical Treatment for Degenerative Disc Disease. MD. Thanks for the A2A. The discs also may bulge into the spinal canal. These issues can be debilitating and affect people throughout their lives. ... inducing a significant post-operative loss of disc height. Author information: ( Question: Im overweight, and Ive had severe back pain caused by a herniated disc. A disc injury is among the most common types of back ailments. 1. Hypothesis evaluation. Greater volumes of disc removal were associated with accelerated disc height loss. I have had two herniations that required laminectomies and one herniation that did not. 1 thank. ...
In our study, the aims were to describe the changes in the appearance of the lumbar spine on MRI in elite fast bowlers during a follow-up period of one year, and to determine whether these could be used to predict the presence of a stress fracture of the posterior elements. We recruited 28 elite fast bowlers with a mean age of 19 years (16 to 24) who were training and playing competitively at the start of the study. They underwent baseline MRI (season 1) and further scanning (season 2) after one year to assess the appearance of the lumbar intervertebral discs and posterior bony elements. The incidence of low back pain and the amount of playing and training time lost were also recorded. In total, 15 of the 28 participants (53.6%) showed signs of acute bone stress on either the season 1 or season 2 MR scans and there was a strong correlation between these findings and the later development of a stress fracture (p | 0.001). The prevalence of intervertebral disc degeneration was relatively low. There was no
Intervertebral disc syndrome[edit]. Also commonly called spinal disc herniation, this is where the intervertebral disc bulges ... "Intervertebral Disk Disease (Herniations of the Disk)". VeterinaryPartner.com. Retrieved 2009-11-21.. ... as well as a specific range of heart conditions and spinal disc herniation. ...
... more commonly called a slipped disc, is the result of a tear in the outer ring (anulus fibrosus) of the intervertebral disc, ... There are no intervertebral discs. Somites form in the early embryo and some of these develop into sclerotomes. The sclerotomes ... Feeding of the intervertebral discs through the reflex (hyaline ligament) plate that separates the cancellous bone of the ... The upper and lower surfaces of the centrum are flattened and rough in order to give attachment to the intervertebral discs. ...
"Intervertebral Disc Disease". Genetic Welfare Problems of Companion Animals. ufaw.org.uk: Universities Federation for Animal ... Jensen, V. F.; Ersbøll, A. K. (2000). "Mechanical Factors affecting the Occurrence of Intervertebral Disc Calcification in the ... The breed is prone to spinal problems, especially intervertebral disk disease (IVDD), due in part to an extremely long spinal ... "Reoperative Neurosurgery in Dogs With Thoracolumbar Disc Disease". Veterinary Surgery. 28 (6): 421-428. doi:10.1111/j.1532-950X ...
... and widens at the intervertebral disc space. It weakly prevents hyperflexion of the vertebral column and limits spinal disc ... Anterior longitudinal ligament Intervertebral disc Moore, K.; Dalley, A.; Agur, A. (2018). Clinically Oriented Anatomy (8th ed ... herniation, although it is much narrower than the anterior longitudinal ligament, such that spinal disc herniations usually ...
Braund KG, Ghosh P, Taylor TK, Larsen LH (September 1975). "Morphological studies of the canine intervertebral disc. The ... The vertebral bodies are short and flattened with relatively large intervertebral disk height, and there is congenitally ...
2008). "Aquaporin expression in the human intervertebral disc". J. Mol. Histol. 39 (3): 303-9. doi:10.1007/s10735-008-9166-1. ...
Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 24:707-16 Rhodes NP, Bellón JM, Buján MJ, ...
Cushing may have had a ruptured intervertebral disc. He had suffered enough shocks to dislocate half a dozen vertebrae, and ...
... is an intervertebral disc disorder. The facet joints or zygapophyseal joints are synovial cartilage ...
Intervertebral disc Minimal invasive spine surgery Osteoporosis Dalton, BE; AC Kohm; LE Miller; JE Block; RD Poser (19 November ...
Intervertebral disc Sciatica Spinal disc herniation Govind J (2004). "Lumbar radicular pain". Aust Fam Physician. 33 (6): 409- ... and foot as often secondary to nerve root irritation from a spinal disc herniation or from osteophytes in the lumbar region of ...
Commonly, osteophytes and portions of intervertebral disc are removed. Fusion surgery: Performed when there is evidence of ... Thus the chondrocytes which maintain the disc become deprived of nutrition and die. Secondary osteophytes may cause stenosis ... being placed on the vertebrae and the discs between them. The abnormal stress causes the body to form new bone in order to ...
documented limbus vertebrae, intervertebral disc bulges, and disc degeneration. Three of the five practitioners also reported ...
"Mechanobiology of the intervertebral disc and relevance to disc degeneration". J Bone Joint Surg Am. 88 (2): 52-57. doi:10.2106 ... Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading, ... "Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen". Arthritis ... "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". ...
Most amphiarthrosis joints are cartilaginous joints (e.g., intervertebral discs). synovial joint (also known as a diarthrosis ... two or more articulation surfaces and an articular disc or meniscus (e.g. knee joint) The joints may be classified anatomically ...
Interbody Fusion is a graft where the entire intervertebral disc between vertebrae is removed and a bone graft is placed in the ... Chapter 39: Lower Back Pain and Disorders of Intervertebral Discs. In: Canale, S. T. and J. H. Beaty. Campbell's Operative ... The most common cause of pressure on the spinal cord/nerves is degenerative disc disease. Other common causes include disc ... Conditions where spinal fusion may be considered include the following: Degenerative disc disease Spinal disc herniation ...
p112.(PDF) Virgin, W. J. (1951-11-01). "Experimental investigations into the physical properties of the intervertebral disc". ...
Sun Z, Zhang M, Zhao XH, Liu ZH, Gao Y, Samartzis D, Wang HQ, Luo ZJ (2013). "Immune cascades in human intervertebral disc: the ...
The notochord will form the nucleus pulposus of intervertebral discs. There is some discussion as to whether these cells ...
Mercer S, Bogduk N. The Ligaments and Annulus Fibrosus of Human Adult Cervical Intervertebral Discs. Spine 1999 Apr 1; 24(7): ... 7. Panjabi M, et al., Injury Mechanisms of the Cervical Intervertebral Disc During Stimulated Whiplash. Spine. 29, No 11, 2004 ...
Their intervertebral disc material can calcify and become more brittle. In such cases, the disc may rupture, with disc material ... If no signs of pain can be elicited, surgery should be performed within 24 hours of the incident, to remove the disc material ... This is a microscopic piece of disc material that breaks off and becomes lodged in a spinal artery. Nerves served by the artery ...
In 90% of sciatica cases, this can occur as a result of a spinal disc bulge or herniation. Intervertebral spinal discs consist ... A relationship has been proposed with a latent Cutibacterium acnes infection in the intervertebral discs, but the role it plays ... Discography involves the insertion of a needle into a disc to determine the pressure of disc space. Radiocontrast is then ... If sciatica is caused by a herniated disc, the disc's partial or complete removal, known as a discectomy, has tentative ...
Kuo, PP; Loh, ZC (1987). "Treatment of lumbar intervertebral disc protrusions by manipulation". Clin Orthop Relat Res. 215: 47- ... Mensor, M. C (1955). "Non-operative treatment, including manipulation, for lumbar intervertebral disc syndrome". The Journal of ... Mensor, MC (1965). "Non-operative treatment, including manipulation, for lumbar intervertebral-disc syndrome". J Bone Joint ... 47-A: 1073-4. Mensor, MC (Oct 1955). "Non-operative treatment, including manipulation, for lumbar intervertebral disc syndrome ...
In vertebrates the notochord develops into the vertebral column, becoming vertebrae and the intervertebral discs the center of ... A postembryonic vestige of the notochord is found in the nucleus pulposus of the intervertebral discs. Isolated notochordal ... Urban, J. P. G. (2000). "The Nucleus of the Intervertebral Disc from Development to Degeneration". Integrative and Comparative ... Krämer, Jürgen (2009). Intervertebral Disk Diseases: Causes, Diagnosis, Treatment, and Prophylaxis. Thieme. pp. 15-17. ISBN 978 ...
Kraemer J (March 1995). "Natural course and prognosis of intervertebral disc diseases. International Society for the Study of ...
Mixter, WJ; Barr, JS (1934). "Rupture of the Intervertebral Disc with Involvement of the Spinal Canal". N Engl J Med. 211 (5): ... namely lumbar discs. Medical focus on herniated discs was further forwarded by the invention of the MRI in 1977. Over-diagnosis ... work of Mixter and Barr shifted all emphasis in research and treatment from the sacroiliac to the herniated intervertebral disc ... and attention on herniated discs has led to the SI joint becoming an underappreciated pain generator in an estimated 15% to 25 ...
... provides intervertebral disc and cartilage with the ability to resist compressive loads. The localized high ... Sivan SS, Wachtel E, Roughley P (2014). "Structure, function, aging and turnover of aggrecan in the intervertebral disc". ... "The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage". Eur Cell Mater ... This causes discs to get stiffer and less resilient with age. Aggrecan also plays an important role in the organization of the ...
"Hierarchical structure and mechanical properties of collagen in the intervertebral disc". Annals of Biomedical Engineering. 19 ...
Some uses under investigation include a scaffold for intervertebral disc regeneration. Unlike other scaffold materials, the ...
... and intervertebral discs. Brucellosis in the intervertebral disc is one possible cause of discospondylitis. Symptoms of ... Infection of the eye can cause uveitis, and infection of the intervertebral disc can cause pain or weakness. Blood testing of ...
tendon, ligament, skin, cornea, cartilage, bone, blood vessels, gut, and intervertebral disc. ...
Intervertebral disc. *Sciatica. *Spinal disc herniation. ReferencesEdit. *^ Govind J (2004). "Lumbar radicular pain". Aust Fam ... and foot as often secondary to nerve root irritation from a spinal disc herniation or from osteophytes in the lumbar region of ...
The smaller middle part of the ligament connects to the intervertebral disc. This plane joint is known as the articulation of ... at the intervertebral disc. Another ligament, the radiate ligament joins the head of the rib to the both the body of the upper ...
... the others are separated by intervertebral discs) and the four coccygeal bones which form the tailbone. The upper three regions ...
Intervertebral discs *Discectomy. *Annuloplasty. *Arthroplasty. Upper extremity. *Shoulder surgery *Shoulder replacement. * ...
Furthermore, the Z-disc seemed to have evolved differently even within bilaterians and there is a great deal diversity of ... The only epaxial muscles in humans are the erector spinae and small intervertebral muscles, and are innervated by the dorsal ... Through this divergence of the Z-disc, Steimetz et al. argue that there are only four common protein components that were ... Cardiac muscle fibers are interconnected by intercalated discs,[12] giving that tissue the appearance of a syncytium. ...
Gliding motions occur between flat surfaces, such as in the intervertebral discs or between the carpal and metacarpal bones of ...
Intervertebral discs *Discectomy. *Annuloplasty. *Arthroplasty. Upper extremity. *Shoulder surgery *Shoulder replacement. * ...
The lumbosacral joint, between the sacrum and the last lumbar vertebra, has, like all vertebal joints, an intervertebral disc, ...
The aortic arch ends and the descending aorta begins at the level of the intervertebral disc between the fourth and fifth ...
Low back intervertebral disc surgery. *Incise finger tendon sheath. *Repair of ankle fracture (fibula) ...
... metal discs (electrodes) attached to the scalp. Routinely, EEG is used in clinical circumstances to determine changes in brain ...
Axial images through the spine will only show one vertebral body at a time and cannot reliably show the intervertebral discs. ...
It may be secondary to intervertebral disk herniation (most commonly at C7 and then the C6 level), degenerative disc disease, ... Heckmann JG, Lang CJ, Zöbelein I, Laumer R, Druschky A, Neundörfer B (October 1999). "Herniated cervical intervertebral discs ... Saal JA, Saal JS (April 1989). "Nonoperative treatment of herniated lumbar intervertebral disc with radiculopathy. An outcome ... showing a stenosis of the left intervertebral foramen of cervical spinal nerve 4, corresponding with the affected dermatome. ...
intervertebral disc (anulus fibrosus. *nucleus pulposus). Synovial joint. Atlanto-axial. *Medial: Cruciate ligament of atlas ( ...
... intervertebral disc surgery, rotator cuff surgery, and musculoskeletal disorders, among others.[50] Other areas of orthopedic ...
Vertebrae and intervertebral discs: see Template:Bone, cartilage, and joint procedures. Medical imaging. *Computed tomography ... Instead, a mobile disc could be implanted into the disc space to maintain mobility. This is commonly used in cervical disc ... Disc herniations of spinal vertebral discs are removed with special rongeurs. This procedure is known as a discectomy. ... Generally once a disc is removed it is replaced by an implant which will create a bony fusion between vertebral bodies above ...
Intervertebral disc disorder. *Schmorl's nodes. *Degenerative disc disease. *Spinal disc herniation. *Facet joint arthrosis ... As bones start to become weaker and the ligaments and discs located in the spine become worn as a result of age-related changes ... As the person aged, there would be increased wear and tear, early onset arthritis, disc degeneration, muscular stiffness, and ... Calcium deposits in the cartilage endplate and sometimes in the disc itself[13] ...
Results may indicate lesion to the spinal cord nerve root, or intervertebral disc herniation pressing on the spinal nerve roots ...
"Immune cascades in human intervertebral disc: the pros and cons". International Journal of Clinical and Experimental Medicine] ...
Vertebrae and intervertebral discs: see Template:Bone, cartilage, and joint procedures. Medical imaging. *Computed tomography ...
Intervertebral discs *Discectomy. *Annuloplasty. *Arthroplasty. *Back examination *Straight leg raise. *Waddell's signs ...
... and from the neighboring intervertebral discs. The lumbar plexus lies between the two layers.[1] ... Tightness of the psoas can result in spasms or lower back pain by compressing the lumbar discs.[9] A hypertonic and inflamed ... Transverse processes of T12-L4 and the lateral aspects of the discs between them. ...
Urban, J. P. G. (2000). "The Nucleus of the Intervertebral Disc from Development to Degeneration". Integrative and Comparative ... A postembryonic vestige of the notochord is found in the nucleus pulposus of the intervertebral discs. Isolated notochordal ... while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc.[1] The notochord plays a key role in ...
Intervertebral discs *Discectomy. *Annuloplasty. *Arthroplasty. Upper extremity. *Shoulder surgery *Shoulder replacement. * ...
... the bronchial tubes and the intervertebral discs. It is not as hard and rigid as bone but is stiffer and less flexible than ...
... which in turn improves intervertebral disc and bone strength.[82]. Hormone replacement therapy in the form of estrogen and ...
An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc ... infection of the intervertebral disc).[medical citation needed] The intervertebral disc functions to separate the vertebrae ... The fibrous intervertebral disc contains the nucleus pulposus and this helps to distribute pressure evenly across the disc. ... Stuttgart: Thieme Intervertebral Discs Spinal Disc Summary Cross section image: pembody/body12a-Plastination Laboratory at the ...
... of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently ... Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) ... any part of the spine can have disc degeneration. Depending on the location of the affected disc or discs, intervertebral disc ... medlineplus.gov/genetics/condition/intervertebral-disc-disease/ Intervertebral disc disease. ...
The term intervertebral disc annuloplasty indicates any procedure aimed at repairing the annulus of a bulging intervertebral ... The heat is intended to seal any ruptures in the disc wall and may also burn nerve endings, which can make the area less ... Disc biacuplasty Intradiscal Electrothermal Annuloplasty from The American Academy of Orthopaedic Surgeons v t e. ... is a recently developed minimally invasive form of annuloplasty consisting of the insertion in the affected disc of a hollow ...
An artificial disc having a pair of opposing baseplates, for seating against opposing vertebral bone surfaces, separated by a ... Intervertebral disc prosthesis with contact blocks. US6582466. Dec 9, 1999. Jun 24, 2003. Stryker Spine. Intervertebral disc ... Intervertebral implant. US5314477. Mar 4, 1991. May 24, 1994. J.B.S. Limited Company. Prosthesis for intervertebral discs and ... Artificial Spinal Disc. US20090048674 *. Aug 13, 2008. Feb 19, 2009. Spinecore, Inc.. Artificial intervertebral disc having an ...
An intervertebral disc, which separates joining vertebrae, is fastened to the roughened upper and lower surfaces of the drum- ... The intervertebral discs cushion and soften the forces created by walking and jumping, which might otherwise fracture the ... Each intervertebral disk is composed of a band of fibrous fibrocartilage (anulus fibrosus) that surrounds a gelatinous core, ... On the surfaces of the vertebral pedicles are notches that align to create openings, called intervertebral foramina. These ...
The disc, in its preferred embodiment, is comprised of disc-shaped plates 11(a&b) joined by springs alon ... This invention comprises of a synthetic intervertebral disc for implantation in the human body. ... this invention relates to a synthetic intervertebral disc that is implantable to replace a damaged intervertebral disc. ... 1. A synthetic intervertebral disc that is implantable between two vertebrae, the disc comprising: (a) a substantially rigid ...
Helpful if you want to understand whats causing your disc-related back pain. ... A spine surgeon explains what the intervertebral disc is in this short segment. ... What Can Happen to an Intervertebral Disc? (And Lead to Pain for You). The intervertebral disc can be a source of back pain or ... What Is an Intervertebral Disc?. In your spine, you have bones called the vertebrae, and in between those, you have discs that ...
A spinal implant for replacing the natural nucleus of the disc made from a polymer such as hydrogel having a radiopaque ... Because the intervertebral disc is avascular, most nutrients that the disc needs for metabolism are transported to the disc by ... An intervertebral disc prosthetic consisting of a pair of rigid plugs to replace the degenerated disc is referred by Kuntz, U.S ... Radiopaque Prosthetic Intervertebral Disc Nucleus. US20070276491 *. May 24, 2006. Nov 29, 2007. Disc Dynamics, Inc.. Mold ...
A prosthetic disc for insertion between adjacent vertebrae includes a core having upper and lower curved surfaces, upper and ... Intervertebral prosthetic disc. US20050192670 *. 11 Feb 2005. 1 Sep 2005. Spinecore, Inc.. Artificial intervertebral disc ... Intervertebral prosthetic disc. US8845729. 25 Nov 2009. 30 Sep 2014. Simplify Medical, Inc.. Prosthetic disc for intervertebral ... Intervertebral prosthetic disc. US9439775. 22 May 2014. 13 Sep 2016. Simplify Medical Pty Ltd. Artificial intervertebral disc ...
Simulation of the intervertebral disc (IVD) degeneration in animal models is of great interest towards exploration and ... "Healing of a painful intervertebral disc should not be confused with reversing disc degeneration: implications for physical ... Intervertebral disc Degeneration Biphasic theory Biomechanics This is a preview of subscription content, log in to check access ... Simulation of the intervertebral disc (IVD) degeneration in animal models is of great interest towards exploration and ...
The invention relates to a postero-lateral intervertebral disc prosthesis characterised in that: the insert (,b,1,/b,) has a ... scannographic signs of disc degeneration with a disc cavity, and signs in nuclear magnetic resonance of disc degeneration with ... 1. Postero-lateral intervertebral disc prosthesis comprising an element (3) mounted with an orientation and self-centering ... among which one can note lumbago or sprain with disc tearing, disc hernia and disc insufficiency. ...
The disc member defines a longitudinal axis and a lateral axis transverse to the longitudinal axis. The disc member includes an ... to the longitudinal axis whereby upon insertion of the disc member within the intervertebral space forces exerted on the disc ... for insertion within an intervertebral space between adjacent vertebrae to replace at least a portion of an intervertebral disc ... The disc member may include an interior cavity disposed within the exterior wall portion with the first and second slits ...
The present invention relates to an intervertebral disk prosthesis comprising at least three parts including a first plate, ... 7.挋煩杁利覀氿1皈椓间盖偋佌3牴彼圧亏4每丫凼彛裃置皈尻寸稌導亏每丫凼彛裃置皈尻寸3仑耔胾夛圧芯孑(3)和三枃(2)乌间具有徳導皈间際》 7. The intervertebral disc prosthesis as claimed in claim ... 5.挋煩杁利覀氿1皈椓间盖偋佌3牴彼圧亏4芯孑(3)
The intervertebral prosthetic disc can include a first component that can have a first compliant layer that can be configured ... Further, the intervertebral prosthetic disc can include a second component that is configured to engage the second vertebra. ... An intervertebral prosthetic disc is disclosed and can be installed within an intervertebral space between a first vertebra and ... The intervertebral discs function as shock absorbers and as joints. Further, the intervertebral discs can absorb the ...
Intervertebral Discs. Intervertebral Discs. - See: - Diskitis. - Herniated Disc in the Adult: (discussion and evaluation). - ... the L4-L5 disc is the largest and therefore the most avascular intervertebral disc;. - normal curvature of lumbar column is due ... Disc pressure measurements.. 1991 Volvo Award in basic sciences. Collagen types around the cells of the intervertebral disc and ... lumbar disc herniation: (discussion and evaluation). - diskectomy:. Proteoglycans of human infant intervertebral disc. Electron ...
An externally guidable intervertebral disc apparatus also is disclosed. ... An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant ... An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a ... Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and ...
... from degenerative disc disease to bulging and herniated discs. ... get treatment for issues that affect the intervertebral discs, ... Intervertebral disc issues. Intervertebral discs can be affected by a number of issues, but biggest one is probably the natural ... A bulging disc occurs when the disc weakens or degenerates and protrudes into the spinal canal. A herniated disc is when the ... An intervertebral disc is a layer of cartilaginous material that acts as a shock absorber between each vertebra. Along with the ...
Intervertebral Disc Disease - Cody Hiles by cody hiles , This newsletter was created with Smore, an online tool for creating ... Any disorder with the intervertebral disc. This is usually caused by the degenerative process with aging or taking a forceful ... herniated disc A disc slips out of the space and may end up pinching a nerve ... herniated disc A disc slips out of the space and may end up pinching a nerve ...
... prolapsed disc, slipped disc, herniated disc, disc protrusion, disc extrusion, intervertebral disc displacement, disc disease ... Figure 3b: Vertebral disc extrusion. In these cases, the outer layer of the disc ruptures and the disc contents are extruded ... Intervertebral Disc Disease (IVDD). Related terms: Ruptured disc, ... The absence of radiological disc calcifications does not exclude degenerative changes in the disc nor does it exclude disc ...
Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus ... The methods comprise introducing an amount of the polyelectrolyte materials into the intervertebral disc space without removing ... The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using ... wherein the intervertebral disc is experiencing progressive disc collapse, and bulking up the intervertebral disc decreases the ...
Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and ... in depicting intervertebral disc alterations was tested on the magnetic resonance images of 300 lumbar intervertebral discs in ... Magnetic resonance classification of lumbar intervertebral disc degeneration Spine (Phila Pa 1976). 2001 Sep 1;26(17):1873-8. ... Conclusion: Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system ...
Among the growth factors involved in disc homeostasis, the rs4871857 SNP of GDF5 was associated with IVDD. VEGF SNPs -2578C/A ... Results: SNPs in the genes coding for structural proteins linked with IVDD or disc bulging include the Sp1 polymorphism of ... SNPs in the genes coding for structural proteins linked with IVDD or disc bulging include the Sp1 polymorphism of COL1A1, Trp3 ... Intervertebral disc degeneration (IVDD) is considered a multifactorial disease. The last two decades of research strongly ...
Age-related changes in fibromodulin and lumican in human intervertebral discs.. Sztrolovics R1, Alini M, Mort JS, Roughley PJ. ... Lumbar intervertebral discs were obtained from individuals of different ages, and extracts of anulus fibrosus and nucleus ... To investigate the changes in structure and abundance of fibromodulin and lumican in human intervertebral discs during aging ... Growth, aging, and degeneration of the intervertebral disc are associated with changes in the abundance and structure of ...
... Umile Giuseppe Longo,1,2 Nicola ... "Mesenchymal Stem Cell for Prevention and Management of Intervertebral Disc Degeneration," Stem Cells International, vol. 2012, ...
... David Oehme,1,2 Tony Goldschlager,1,2 Jeffrey ... Access to the ovine lumbar intervertebral discs has traditionally been via an anterior or anterolateral approach, which ... excellent visualisation of intervertebral discs, and minimal abdominal retraction and is well tolerated by animals with minimal ...
... intervertebral discs are made up of fibrocartilage tissue, which has two layers. While the inner portion resembles jelly, the ... NYLMC explains that intervertebral discs lose water over time, which causes them to compact. This is why people become slightly ... If a discs outer layer breaks down and lets the soft inner core emerge, it results in a herniated or "slipped" disc and extra ... According to the New York University Langone Medical Center, intervertebral discs are made up of "fibrocartilage tissue," which ...
... and a nonlinear constitutive parameter for the annulus fibrosis were obtained by matching experimental results for the discs ... rate-independent behavior of human intervertebral discs is studied with a finite element model which incorporates a nonlinear ... The nonlinear, rate-independent behavior of human intervertebral discs is studied with a finite element model which ... It is shown that there are marked differences in the compressive behavior of lumbar and thoracic discs. In addition, two types ...
Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans.. Zhang YG1, Guo X, Xu P, ... We used the rabbit intervertebral disc as a model, creating three groups: an uninjected control group, a group injected with ... supporting its potential use as a treatment of intervertebral disc degeneration. ... allogeneic bone mesenchymal stem cells can survive and increase the amount of proteoglycans in intervertebral discs. ...
In addition, the role of collagen IX in intervertebral disc disease is supported by the finding of intervertebral disc ... The following radiological findings were considered as indications of intervertebral disc disease: (i) disc extrusion; (ii) any ... Intervertebral disc disease is among the most common musculoskeletal disorders. It is a major cause of work disability and an ... An Allele of COL9A2 Associated with Intervertebral Disc Disease Message Subject. (Your Name) has forwarded a page to you from ...
Background Intervertebral disc degeneration is a common condition with few inexpensive and effective modes of treatment, but ... Intervertebral Disc Nucleus Pulposus Disc Herniation Disc Degeneration Annulus Fibrosus These keywords were added by machine ... The ontogenetic development of nerve terminations in the intervertebral discs of man: histology of intervertebral discs, 11th ... Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells. 2006;24:707-716.PubMedGoogle Scholar ...
  • Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. (medlineplus.gov)
  • The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine. (medlineplus.gov)
  • As a disc degenerates, small bony outgrowths (bone spurs) may form at the edges of the affected vertebrae. (medlineplus.gov)
  • Over time, a degenerating disc may break down completely and leave no space between vertebrae, which can result in impaired movement, pain, and nerve damage. (medlineplus.gov)
  • Variants in genes that play roles in the development and maintenance of the intervertebral discs and vertebrae have also been found to be associated with intervertebral disc disease. (medlineplus.gov)
  • An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. (wikipedia.org)
  • Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold the vertebrae together, and to function as a shock absorber for the spine. (wikipedia.org)
  • The nucleus of the disc acts as a shock absorber, absorbing the impact of the body's activities and keeping the two vertebrae separated. (wikipedia.org)
  • There is one disc between each pair of vertebrae, except for the first cervical segment, the atlas. (wikipedia.org)
  • The intervertebral disc space is typically defined on an X-ray photograph as the space between adjacent vertebrae. (wikipedia.org)
  • medical citation needed] The intervertebral disc functions to separate the vertebrae from each other and provides the surface for the shock-absorbing gel of the nucleus pulposus. (wikipedia.org)
  • An intervertebral disc, which separates joining vertebrae, is fastened to the roughened upper and lower surfaces of the drum-shaped bodies of the vertebrae. (innerbody.com)
  • The intervertebral discs cushion and soften the forces created by walking and jumping, which might otherwise fracture the vertebrae or jar the brain. (innerbody.com)
  • The spring system distributes forces acting on the disc between the springs and allows normal movement of the vertebrae during flexion and extension of the spine in any direction. (freepatentsonline.com)
  • In your spine, you have bones called the vertebrae, and in between those, you have discs that help cushion your movements. (spineuniverse.com)
  • When a disc thins, it causes the vertebrae above and below it to become closer together. (spineuniverse.com)
  • A prosthetic disc for insertion between adjacent vertebrae includes a core having upper and lower curved surfaces, upper and lower plates, and peripheral restraining structure on at least one of the upper plate, the lower plate and the core. (google.co.uk)
  • 12 . A prosthetic disc as in claim 1 , wherein the outer surfaces of the upper and lower plates have at least one surface feature for promoting attachment of the outer surfaces to the vertebrae. (google.co.uk)
  • An intervertebral prosthesis dimensioned for insertion within an intervertebral space between adjacent vertebrae to replace at least a portion of an intervertebral disc removed therefrom, includes a disc member having sufficient rigidity to support the adjacent vertebrae in spaced relation. (google.com.au)
  • 11. The interval prothesis according to claim 1 wherein the disc member includes first and second support surfaces disposed at respective longitudinal ends of the disc member and being dimensioned to supportingly engage vertebral portions of respective vertebrae. (google.com.au)
  • The annulus fibrosus surrounds the nucleus pulposus and is made of strong, fibrous cartilage that gives the disc structure and enables even weight distribution of neighboring vertebrae. (laserspineinstitute.com)
  • Damaged intervertebral discs can also increase the likelihood of developing spinal arthritis and bone spurs due to the extra pressure it puts on the vertebrae. (laserspineinstitute.com)
  • IVDD is a disease that affects the disc-shaped cushions of tissue between the bones on the back (vertebrae). (aspcapetinsurance.com)
  • Intervertebral disc disease (IVDD) is a condition where the discs between the vertebrae of the spinal cord degenerate, causing pain and neurological problems. (bowwowinsurance.com.au)
  • Intervertebral disc (IVD) degeneration is an age-related condition that occurs as a result of one or more of the discs between the vertebrae of the spinal column deteriorates or breaks down, leading to pain. (portlandpress.com)
  • The rubbery discs between the vertebrae normally allow for flexing and bending of the back, like shock absorbers. (portlandpress.com)
  • IVDs, also known as intervertebral fibrocartilage or spinal discs, provide the much-needed padding between the vertebrae of the spine. (portlandpress.com)
  • In the kyphosis group, the upper thoracic vertebrae (T1 - T6) showed significantly higher intervertebral pressure than the normal group. (scirp.org)
  • Spinal discs are located between the vertebrae (blocks of bone) of the spine (expect the upper 2). (healthtap.com)
  • The spine plays a foundational role in mammalian motility with associated spinal muscles attached to the vertebrae, by way of origins and insertions, and crossing intervertebral discs (IVDs) (see Figure 1 , for example). (jcircadianrhythms.com)
  • Intervertebral discs are fibrocartilaginous cushions between the vertebrae (except the first two cervical vertebrae) that allow movement, are supportive and act as shock absorbers. (fitzpatrickreferrals.co.uk)
  • Intervertebral disc Fibrocartilaginous cushions between the vertebrae that allow movement in the spinal column, are supportive and act as shock absorbers." class="glossaryLink ">Intervertebral disc degeneration results in diminished shock-absorbing capacity, and can ultimately lead to disc herniation and spinal cord compression. (fitzpatrickreferrals.co.uk)
  • They consist of three major components: the inner, nucleus pulposus (NP), the outer, annulus (AF) and the cartilaginous endplates that anchor the discs to adjacent vertebrae. (physio-pedia.com)
  • Intervertebral discs sit in between the vertebrae and act as shock absorbers for the spine. (marinahospital.com)
  • The associated variants can lead to disc degeneration and herniation. (medlineplus.gov)
  • A spinal disc herniation, commonly referred to as a slipped disc, can happen when unbalanced mechanical pressures substantially deform the anulus fibrosus, allowing part of the nucleus to obtrude. (wikipedia.org)
  • Another kind of herniation, of the nucleus pulposus, can also happen as a result of the formation of Schmorl's nodes on the intervertebral disc. (wikipedia.org)
  • This is referred to as vertical disc herniation. (wikipedia.org)
  • Articles were excluded if they investigated lower back pain or just disc herniation without an analysis of disc degeneration. (frontiersin.org)
  • It is usually related to either disc protrusion or herniation, which will cause both chemical and mechanical irritation of the nerve root. (sciencemag.org)
  • This is supported by findings of a considerable genetic predisposition to early-onset sciatica and lumbar disc herniation in certain families ( 4 ). (sciencemag.org)
  • CT and MRI scans in thoracic intradural disc herniation. (currentprotocols.com)
  • A slipped disc' is an abnormal protrusion (herniation) of the central portion through a damaged region or tear of the fibrocartilage. (sciencephoto.com)
  • The most common sites of disc herniation are the cervical (neck) and thoracolumbar (upper back) regions. (bowwowinsurance.com.au)
  • Degeneration results in the ossification or hardening and herniation of the disc. (beaglesunlimited.com)
  • To clarify how nerve root impairment affects the histochemical properties of the lumbar multifidus muscle in patients with lumbar intervertebral disk herniation. (unboundmedicine.com)
  • AU - Yoshihara,K, AU - Shirai,Y, AU - Nakayama,Y, AU - Uesaka,S, PY - 2001/3/14/pubmed PY - 2001/5/25/medline PY - 2001/3/14/entrez SP - 622 EP - 6 JF - Spine JO - Spine VL - 26 IS - 6 N2 - STUDY DESIGN: The histochemical changes in the multifidus muscle in 29 patients with L4-L5 lumbar intervertebral disc herniation were studied. (unboundmedicine.com)
  • Epstein J. A. The syndrome of herniation of the lower thoracic intervertebral discs with nerve root and spinal cord compression. (thejns.org)
  • Regarding resorption of herniated intervertebral discs, recent studies of magnetic resonance images and histologic investigations of surgically resected specimens in lumber disc herniation patients have been reported. (ovid.com)
  • Intervertebral disc disease Age-related, degenerative condition of intervertebral discs resulting in deminished shock-absorbing capacity leading to disc herniation and spinal cord compression." class="glossaryLink ">Intervertebral disc disease (IVDD) is the most common spinal disease in dogs and is also seen occasionally in cats. (fitzpatrickreferrals.co.uk)
  • Disc degeneration results in diminished shock-absorbing capacity, and can ultimately lead to disc herniation and spinal cord compression. (fitzpatrickreferrals.co.uk)
  • The types of disc herniation are often described as Hansen type I (nucleus pulposus degeneration and extrusion), and Hansen type II (annulus fibrosis degeneration and protrusion). (fitzpatrickreferrals.co.uk)
  • Hansen type-I intervertebral disc disease 'Extrusion' or 'herniation' of the inner contents of the intervertebral disc." class="glossaryLink ">Hansen type-I intervertebral disc disease is most easily described as an 'extrusion' or 'herniation' of the inner contents of the intervertebral disc. (fitzpatrickreferrals.co.uk)
  • To assess the correlation between lumbar disc degeneration (LDD), multifidus muscle atrophy (LMA), and facet joints degeneration in patients with L4-L5 lumbar disc herniation (LDH). (pubmedcentralcanada.ca)
  • Lumbar disc herniation (LDH) is one of the most frequent causes of low back pain and sciatic pain in adults. (pubmedcentralcanada.ca)
  • However, there have only been a few reports on magnetic resonance imaging (MRI) analysis of the paraspinal muscles [ 11 ], facet joints, and lumbar disc degeneration (LDD) in LDH patients, let alone the correlation study of lumbar degenerative changes between herniated and adjacent segments in patients with L4-L5 disc herniation. (pubmedcentralcanada.ca)
  • The occurrence of lumbar disc herniation is closely related to the mechanical state, and it is necessary to study the internal mechanical behavior of the intervertebral disc under different loading conditions. (alliedacademies.org)
  • Lumbar disc herniation is the extrusion of the nucleus pulposus out of the rupture of the annulus fibrosus, and the bulging tissue squeezes the spinal nerves continuously, leading to low back pain [ 1 , 2 ]. (alliedacademies.org)
  • Goldschlager, Tony 2018-03-01 00:00:00 Background ContextNeural compression associated with lumbar disc herniation is usually managed surgically by microdiscectomy. (deepdyve.com)
  • region of the spine are most often affected in intervertebral disc disease, any part of the spine can have disc degeneration. (medlineplus.gov)
  • There are 23 discs in the human spine: 6 in the neck (cervical) region, 12 in the middle back (thoracic) region, and 5 in the lower back (lumbar) region Discs are named by the vertebral body above and below. (wikipedia.org)
  • In this short video, you can hear a spine surgeon's explanation of the intervertebral disc. (spineuniverse.com)
  • The discs are also the shock absorbers of your spine. (spineuniverse.com)
  • This is usually caused by the degenerative process with aging or taking a forceful impact to the spine which causes the disc to either rupture or slightly slip out of place. (smore.com)
  • To understand intervertebral disc disease some knowledge of the anatomy of the spine (the backbone) of dogs is needed. (ufaw.org.uk)
  • We present a new minimally invasive operative technique for a far-lateral approach to the ovine lumbar spine that allows for smaller incisions, excellent visualisation of intervertebral discs, and minimal abdominal retraction and is well tolerated by animals with minimal morbidity. (hindawi.com)
  • He had a herniated disc in his spine which left his back legs paralyzed. (gofundme.com)
  • Your pup will need to be put under anesthesia for the process, which requires a special dye to be injected into the spine so the disc and spinal cord appear on the X-rays. (aspcapetinsurance.com)
  • Neck and back pain caused by intervertebral disc (IVD) degeneration is a frequent cause of referral to spine surgeons. (medworm.com)
  • IVDD is caused by the degeneration of one or more intervertebral discs that function as cushions between the vertebral bones of the spine. (beaglesunlimited.com)
  • Until now, the question whether spine trauma in the specific case is associated with damage of the intervertebral disc that ultimately leads to organ degeneration, remains controversial. (wheelessonline.com)
  • It becomes even more difficult to evaluate the effects of traumatic events to the spine (and discs) without a bony fracture, instantly visible damage of the disc organ or idiopathic disc degeneration that was already present. (wheelessonline.com)
  • In spine trauma, any direction of force induction into the intervertebral disc such as compression, distraction and rotation/translation can lead to a disc injury or disc failure depending on the involved energy. (wheelessonline.com)
  • In a specific clinical case, it is often difficult to fully assess disc damage as information on the direction of involved forces and the amount of induced energy are incomplete (Fig. 7-2 A-C). Furthermore, biomechanics differ significantly in the specific regions of the spine and the different imaging modalities, biomechanical testing measures and histological as well as immunological methods are evolving. (wheelessonline.com)
  • This is new knowledge showing that the intervertebral discs can be positively affected by physical activity," says Helena Brisby, an associate professor at the Department of Orthopaedics at Sahlgrenska Academy and spine surgeon at Sahlgrenska University Hospital. (medicalxpress.com)
  • Pain in the lumbar spine is common and may be due to disc degeneration, which means that the disc cells no longer have normal functions. (medicalxpress.com)
  • Degenerative changes in the intervertebral discs of the spine, although common due to natural aging, can present as severe pain and biomechanical dysfunction which requires surgical intervention. (imechanica.org)
  • He had showed failure in natural history and conservative management relief in both symptomatic and functional improvement, due to injury to the intervertebral joints of his lower lumbar spine. (chiro.org)
  • Purpose: We examined the postoperative changes of the cervical spine after treatment of cervical nerve root compression with anterior cervical discectomy and fusion with a new titanium intervertebral disc. (osti.gov)
  • Dr. Wilke's team had implanted an electrical measuring probe into an intervertebral disc of the lumbar spine of a member of this group (also an orthopaedist) in order to be able to precisely measure the pressures in the intervertebral disc in various postures and movement sequences. (biosaffair.de)
  • It was found that the pressure in the disc does not depend on the angle of flexion, i.e. not on how the spine is aligned, whether it is straight or curved. (biosaffair.de)
  • Using this novel model with separated thoracic spine and modified muscle path reflecting actual physiological curvature, disc pressure closer to the realistic condition was obtained. (scirp.org)
  • Intervertebral disc pressure in the upper thoracic spine in the kyphosis group was significantly increased compared with that in the normal group. (scirp.org)
  • Moreover, intervertebral disc pressures in the upper thoracic spine correlated negatively with LL. (scirp.org)
  • In order for a disc to affect the spinal cord, we are talking about a problem in the lower thoracic spine, or a rather unusual high lumbar disc fragment, perhaps. (healthtap.com)
  • This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. (doereport.com)
  • Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. (doereport.com)
  • The intervertebral disc (IVD) is important in the normal functioning of the spine. (physio-pedia.com)
  • A gel-like structure that sits at the center of the intervertebral disc and accounts for much of the strength and flexibility of the spine. (physio-pedia.com)
  • Disc disorders" is a broad term used in the ICD-10-CM Tabular List to describe many problems associated with the spine. (icd10monitor.com)
  • The disc disorder codes are separated into two categories: M50 for the cervical spine and M51 for the thoracic and lumbar spine. (icd10monitor.com)
  • Intervertebral disc excision is commonly performed to treat herniated or ruptured discs in the lumbar section of the spine. (marinahospital.com)
  • Plain radiographs (from the cervical spine, thoracic spine to the lumbar spine) were examined for the presence of disc space narrowing and/or osteophytosis using the Kellgrenâ Lawrence (KL) grading system. (garvan.org.au)
  • The intervertebral disc is a complex structure that transmits and distributes large loads on the spine while providing flexibility [ 22 ]. (alliedacademies.org)
  • There is very limited research published in the literature that applies content-based image retrieval (CBIR) techniques to retrieval of digitized spine X-ray images using a combination of inter-vertebral disc space and shape profiles. (nih.gov)
  • Experimental results show that the proposed algorithm is a promising approach for disc space-based spine X-ray image retrieval. (nih.gov)
  • Chang Y, Antani S , Lee DJ, Gledhill K, Long LR , Christensen P. CBIR of Spine X-ray Images on Inter-vertebral Disc Space and Shape Profiles Proc IEEE CBMS. (nih.gov)
  • It has previously been reported that NP cells, which share the common features of chondrocytes, play critical roles in maintaining integrity of intervertebral discs (IVDs) ( 7 , 8 ). (spandidos-publications.com)
  • We investigated the expression of SDF-1 and CXCR4 in intervertebral discs (IVDs). (medsci.org)
  • SDF-1 and CXCR4 were both expressed in IVDs, and the levels of SDF-1 and CXCR4 were both significantly higher in the degeneration group than in the normal group of human (or rat) discs. (medsci.org)
  • Lumbar intervertebral discs (IVDs) are prone to degeneration upon skeletal maturity. (inserm.fr)
  • Although NP migration has been shown to behave predictably in asymptomatic discs, a variable pattern of migration occurs in people with symptomatic and/or degenerative IVDs [18] . (physio-pedia.com)
  • The mechanical behaviour and cellular metabolism of intervertebral discs (IVDs) and articular cartilage are strongly influenced by their proteoglycan content and associated osmotic properties. (ecmjournal.org)
  • STUDY DESIGN: In vitro study to develop an intervertebral disc degeneration organ culture model, using coccygeal bovine intervertebral discs (IVDs) and injection of proteolytic enzymes MMP-3, ADAMTS-4, and HTRA1. (uzh.ch)
  • Tissue-engineered intervertebral discs (IVDs) utilizing decellularized extracellular matrix (ECM) could be an option for the reconstruction of impaired IVDs due to degeneration or injury. (figshare.com)
  • Research of Intervertebral Disc Degeneration has been linked to Abnormal Degeneration, Pain, Intervertebral Disk Displacement, Back Pain, Low Back Pain. (novusbio.com)
  • Symptoms of Intervertebral disc displacement lumbar w/o myelopathy? (healthtap.com)
  • Have displacement of lumber intervertebral disc w/o myelopathy follow up treatment fluoroscopy procedure snr consider myelogram can I work again hurts? (healthtap.com)
  • M50.2- and M51.2- are the subcategories for "other disc displacement," and this phrase has led to some confusion. (icd10monitor.com)
  • Displacement" is a very general term that does not distinguish between disc bulges or prolapses. (icd10monitor.com)
  • Cervical Intervertebral Disc Displacement in Multiple Sclerosis Patients: A Possible Trigger? (thisisms.com)
  • We used the terms "cervical intervertebral disc displacement", "multiple sclerosis", "neuroinflammation", "pathogenesis" and its combinations. (thisisms.com)
  • It is observed in the context of cervical intervertebral disc displacement (CIDD). (thisisms.com)
  • In this study, the unconfined experiments were conducted by applying an optimized Digital Image Correlation (DIC) technique, and the internal displacement was analysed for the intervertebral disc under axial compression with flexion position. (alliedacademies.org)
  • Our objective was to measure the displacement of the posterior annulus in the intervertebral disc under axial compression with flexion position. (alliedacademies.org)
  • Depending on the location of the affected disc or discs, intervertebral disc disease can cause periodic or chronic pain in the back or neck. (medlineplus.gov)
  • Intervertebral disc disease is estimated to affect about 5 percent of the population in developed countries each year. (medlineplus.gov)
  • Intervertebral disc disease results from a combination of genetic and environmental factors. (medlineplus.gov)
  • Researchers have identified variations in several genes that may influence the risk of developing intervertebral disc disease. (medlineplus.gov)
  • Specific variations in several collagen genes seem to affect the risk of developing intervertebral disc disease by impairing the ability of collagens to interact with each other, decreasing the stability of the disc and leading to its degeneration. (medlineplus.gov)
  • Normal variations in genes related to the body's immune function are also associated with an increased risk of developing intervertebral disc disease. (medlineplus.gov)
  • Researchers are working to identify and confirm other genetic changes associated with an increased risk of intervertebral disc disease. (medlineplus.gov)
  • Nongenetic factors that contribute to the risk of intervertebral disc disease are also being studied. (medlineplus.gov)
  • Intervertebral disc disease can run in families, but the inheritance pattern is usually unknown. (medlineplus.gov)
  • People with a first-degree relative (such as a parent or sibling) with intervertebral disc disease have an increased risk of developing the disorder themselves. (medlineplus.gov)
  • Individuals may inherit a gene variation that increases the risk of intervertebral disc disease, but do not inherit the condition itself. (medlineplus.gov)
  • Not all people with intervertebral disc disease have an identified gene variation that increases the risk, and not all people with such a gene variation will develop the disorder. (medlineplus.gov)
  • This degeneration can be called degenerative disc disease . (spineuniverse.com)
  • As we age, the discs dry out and lose elasticity, potentially leading to a condition called degenerative disc disease. (laserspineinstitute.com)
  • Although degenerative disc disease can occur before age 20, it tends to peak in the fourth and fifth decades of life and declines after that. (smore.com)
  • Severe: intervertebral disc disease occurs frequently in the Dachshund breeds and causes pain which can be severe and prolonged. (ufaw.org.uk)
  • Intervertebral disc degeneration (IVDD) is considered a multifactorial disease that is influenced by both environmental and genetic factors. (frontiersin.org)
  • An electronic literature search was performed using the National Library of Medicine for publications using the keywords genetics of IVDD, lumbar disc degeneration, degenerative disc disease, polymorphisms, SNPs, and disc disease. (frontiersin.org)
  • Intervertebral disc disease is characterized by chondromucinous degeneration of the nucleus pulposus. (nih.gov)
  • Intervertebral disc disease is typically an age-related change in rodents and may be accompanied by variable changes related to bony remodeling, alterations to the cartilaginous endplates, or joint disease (spondylosis, arthrosis), depending on severity and chronicity. (nih.gov)
  • Intervertebral disc disease is one of the most common musculoskeletal disorders. (sciencemag.org)
  • The COL9A2 gene, which codes for one of the polypeptide chains of collagen IX that is expressed in the intervertebral disc, was screened for sequence variations in individuals with intervertebral disc disease. (sciencemag.org)
  • Intervertebral disc disease is among the most common musculoskeletal disorders. (sciencemag.org)
  • A recent twin study suggests that genetic factors may be involved in the pathogenesis of intervertebral disc disease and sciatica ( 3 ). (sciencemag.org)
  • Therefore, intervertebral disc disease appears to be similar to other common complex diseases with multiple genetic forms and a high phenocopy rate, such as breast cancer and Alzheimer's disease. (sciencemag.org)
  • In the veterinary world, the technical term is Intervertebral Disc Disease or IVDD. (aspcapetinsurance.com)
  • Magnetic resonance imaging of intervertebral disk disease. (currentprotocols.com)
  • In dogs, there are two primary disorders that can affect the intervertebral discs, namely, a herniated disc or intervertebral disc disease. (bowwowinsurance.com.au)
  • However, many disc problems suffered by dogs are not caused by an acute traumatic injury, but instead by a degenerative disc disorder known as intervertebral disc disease (IVDD). (bowwowinsurance.com.au)
  • There are two primary forms of Intervertebral Disc Disease that occur in dogs, known as Hansen Type I and Type II. (bowwowinsurance.com.au)
  • Type II IVDD is a rare form of the disease which is linked to the fibrous degeneration of the intervertebral disc and usually affects older large breed dogs. (beaglesunlimited.com)
  • Fingeroth, James is the author of 'Advances in Intervertebral Disc Disease in Dogs and Cats', published 2015 under ISBN 9780470959596 and ISBN 0470959592. (valorebooks.com)
  • Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. (frontiersin.org)
  • Surgical treatments for symptomatic degenerative disc disease (DDD) refractory to conservative measures include spinal fusion, discectomy, and total disc replacement, with spinal fusion being the current standard of care. (frontiersin.org)
  • It needs to be mentioned here that despite its name, degenerative disc disease is not a disease, but a natural occurrence that happens with aging though this debated. (portlandpress.com)
  • reported that the FlexiCore disc compares favorably to fusion to treat lumbar degenerative disc disease that is unresponsive to conservative treatment. (ecri.org)
  • The purpose of this study is to compare the safety and preliminary efficacy of intradiscal injections of two doses of IDCT (Discogenic Cells + Sodium Hyaluronate vehicle) and two controls (saline, Sodium Hyaluronate vehicle) in subjects with chronic low back pain due to Degenerative Disc Disease (DDD) at one lumbar level from L3 to S1. (clinicaltrials.gov)
  • Five disc specimens of 3 cadavers (3 from lumbar L4-5 disc and 2 from thoracic T9-10 disc) with no mentioned disc disease are obtained for control group. (omicsonline.org)
  • Toward the design of novel anti-aging strategies to overcome degenerative disc disease (DDD), we investigated age-correlated phenotypic alterations that occur on primary hIVD cells. (ovid.com)
  • Got cut off, but a strain is a muscular injury, disc space narrowing is a manifestation of degenerative disc disease (analagous to arthritic change), and spondylolysis is a congenital or acquired defect in the lamina, part of the posterior aspect of the vertebra, which can potentially cause pain, instability, and accelerated degenerative arthritis . (healthtap.com)
  • The most common spinal surgery performed in the dog is for intervertebral disc disease. (fitzpatrickreferrals.co.uk)
  • What causes intervertebral disc disease and are there certain breeds at risk? (fitzpatrickreferrals.co.uk)
  • Intervertebral disc disease (IVDD) is an age-related, degenerative condition. (fitzpatrickreferrals.co.uk)
  • Dogs with Hansen type-I disc disease is most common in small breed dogs aged 2 years old and above), although larger breeds can be affected. (fitzpatrickreferrals.co.uk)
  • The incidence of degenerative disc disease caused by intervertebral disc injury is increasing annually, seriously affecting the quality of life of patients and increasing the disease burden on society. (springer.com)
  • The most common cause of paralysis in dogs is intervertebral disk disease . (dfwvetsurgeons.com)
  • An association between multifidus muscle degeneration and chronic low back pain, degenerative disc disease, radiculopathy, and scoliosis has been proposed [ 7 - 9 ]. (pubmedcentralcanada.ca)
  • Mesoblast's double-blind, placebo-controlled Phase 2 clinical trial is being conducted at 15 sites across the United States, and will randomize a total of 100 patients with intervertebral disc disease to receive a non-surgical, percutaneous injection into the intervertebral disc of either low or high dose MPCs with hyaluronic acid carrier, hyaluronic acid carrier alone or saline alone. (technologynetworks.com)
  • Painful intervertebral disc disease is characterised not only by an imbalance between anabolic (i.e., matrix synthesis) and catabolic (i.e., matrix degradation) processes, but also by inflammatory mechanisms. (uzh.ch)
  • NF-kB and MAPK have been identified as the master regulators of inflammation and catabolism in several musculoskeletal disorders (e.g., osteoarthritis), and recently growing evidence supports the importance of these signalling pathways in painful disc disease. (uzh.ch)
  • With continuing research exploiting in vitro and in vivo model systems to elucidate the roles of these pathways in disc degeneration, it may be possible in the near future to specifically target these major inflammatory / catabolic signalling pathways to treat painful degenerative disc disease. (uzh.ch)
  • In this perspective, we aim to summarise the current state of knowledge concerning the inflammatory and catabolic molecular pathways of intervertebral disc disease (IDD), with a detailed description of NF-kB and MAP kinase-mediated signal transduction in disc cells. (uzh.ch)
  • 2. The intervertebral spacer device of claim 1 , wherein the ball's curvate recess has boundaries that define limits of rotation of the ball within the curvate socket in that the ball's rotation within the curvate socket is limited by interference between the convex structure's protrusion and the boundaries. (google.com)
  • Evaluation of end results in treatment of ruptured lumbar intervertebral discs with protrusion of nucleus pulposus. (thejns.org)
  • 250 - 256 1967 Barr JC Kubik CS Molloy MK et al: Evaluation of end results in treatment of ruptured lumbar intervertebral discs with protrusion of nucleus pulposus. (thejns.org)
  • Arseni C. and Nash F. Thoracic intervertebral disc protrusion: A clinical study. (thejns.org)
  • Thoracic intervertebral disc protrusion: A clinical study. (thejns.org)
  • Biochemical and structural changes of disc, narrowing of intervertebral disc space, acute or chronic disc protrusion related to disc degeneration with/without neural symptoms are well documented. (omicsonline.org)
  • An intervertebral prosthetic disc is disclosed and can be installed within an intervertebral space between a first vertebra and a second vertebra. (google.es)
  • The intervertebral prosthetic disc can include a first component that can have a first compliant layer that can be configured to engage the first vertebra. (google.es)
  • Further, the intervertebral prosthetic disc can include a second component that is configured to engage the second vertebra. (google.es)
  • An intervertebral disc is a layer of cartilaginous material that acts as a shock absorber between each vertebra. (laserspineinstitute.com)
  • The disc acts like a cushion between the stacked vertebral bodies and resists compression but allows movements of each vertebra. (sciencephoto.com)
  • The intervertebral discs are circular pads of cushioning fibrocartilage situated between each vertebra of the spinal column. (bowwowinsurance.com.au)
  • If these discs are adjacent to formerly fractured vertebra and the other discs are healthy, a traumatic aetiology may be assumed. (wheelessonline.com)
  • This mechanism slows the rate applied loads are transmitted to the adjacent vertebra, giving the disc its shock absorbing abilities [14] . (physio-pedia.com)
  • We present a novel technique to retrieve vertebra pairs that exhibit a specified disc space narrowing (DSN) and inter-vertebral disc shape profile. (nih.gov)
  • Intervertebral discs contain an abundant extracellular matrix of proteoglycans and collagens ( 5 ). (sciencemag.org)
  • Intervertebral disc (IVD) degeneration is a complicated physiological change involving cellular senescence, inflammation and the degradation of the extracellular matrix. (spandidos-publications.com)
  • We notice that focal eosinophilic change or even necrosis of extracellular matrix is probable an important pathologic picture of degenerative disc and clonal proliferation of chondrocytes is present in all 3 groups of degenerative intervertebral discs. (omicsonline.org)
  • The mechanisms of intervertebral disc degeneration include changes in extracellular matrix (ECM) deposition and tissue fibrosis. (springer.com)
  • The scientific publication, entitled "Immunoselected STRO-3+mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs", can be viewed at http://thejns.org/doi/full/10.3171/2012.1.SPINE11852 . (technologynetworks.com)
  • Following approval by our human subjects institutional review board, we employed microarray analyses to evaluate in vivo expression of MMP28 and the MMP28 precursor in human disc tissue, and utilized immunohistochemistry to determine cellular and extracellular matrix localization of MMP28 in 35 human disc tissue specimens. (eurekamag.com)
  • The present work documents the expression and presence of MMP28 in cells and extracellular matrix (ECM) of the human intervertebral disc. (eurekamag.com)
  • Often this process is happening along with disc deterioration from normal dog life described above, which puts these canines at a much greater risk for IVDD. (aspcapetinsurance.com)
  • With IVDD, the discs can bulge out (protrude) or herniate (burst) into the spinal cord space, causing compression of the spinal cord and nerves at the site. (bowwowinsurance.com.au)
  • Hansen Type I IVDD is an acute, progressive chondroid (cartilage) degeneration of the disc. (bowwowinsurance.com.au)
  • Hansen Type II IVDD involves a slower, more gradual degeneration that leads to chronic bulging of inner disc material into the spinal canal, with subsequent pressure on and compression of the spinal cord. (bowwowinsurance.com.au)
  • It is shown that there are marked differences in the compressive behavior of lumbar and thoracic discs. (cdc.gov)
  • Abbott K. H. and Retter R. H. Protrusions of thoracic intervertebral disks. (thejns.org)
  • Protrusions of thoracic intervertebral disks. (thejns.org)
  • Chesterman P. J. Spastic paraplegia caused by sequestrated thoracic intervertebral disc. (thejns.org)
  • Intervertebral disc pressures in the thoracic and lumbar spines of subjects were analyzed by inverse dynamics analysis using a novel three-dimensional musculoskeletal model, and were compared between the groups. (scirp.org)
  • Intervertebral disc pressure in the thoracic and lumbar spines of patients with spinal deformities was evaluated using a novel thoracolumbar three-dimensional musculoskeletal model. (scirp.org)
  • Is it common for a 29 yr old to have thoracic spondylosis without myelopathy and degeneration of lumbosacral intervertebral disc issues? (healthtap.com)
  • Refer to Lumbar discogenic pain and Thoracic disc syndrome . (physio-pedia.com)
  • Cervical and thoracic herniated discs can also be treated using this technique. (marinahospital.com)
  • Using the technique hydrogels were successfully implanted into a bovine intervertebral disc model. (epfl.ch)
  • Intervertebral discs consist of an outer fibrous ring, the anulus fibrosus disci intervertebralis, which surrounds an inner gel-like center, the nucleus pulposus. (wikipedia.org)
  • The fibrous intervertebral disc contains the nucleus pulposus and this helps to distribute pressure evenly across the disc. (wikipedia.org)
  • Each intervertebral disk is composed of a band of fibrous fibrocartilage (anulus fibrosus) that surrounds a gelatinous core, called the nucleus pulposus. (innerbody.com)
  • The disc is composed of an outer ring of fibrous connective tissue (annulus) and a gelatinous core (nucleus pulposus) composed of collagen and elastin fibers embedded in a chondromucinous matrix with a high water and proteoglycan content. (nih.gov)
  • Most of the intervertebral discs were replaced by fibrous tissues in the lipopolysaccharide group. (ovid.com)
  • Lipopolysaccharide accelerated the replacement of grafted intervertebral disc by fibrous tissue, which suggests the resorption of the disc in the epidural space of the rabbit, whereas high-dose steroid suppressed the replacement. (ovid.com)
  • It is composed of annulus fibrous (AF) and nucleus pulposus (NP) tissue, and nutrients diffuse to the intervertebral disc through the cartilage endplates (CEP). (springer.com)
  • According to the New York University Langone Medical Center, intervertebral discs are made up of "fibrocartilage tissue," which has two layers. (reference.com)
  • Fibrocartilage rings (blue) form the outer margins of the disc, called the nucleus fibrosus. (sciencephoto.com)
  • The chondrocytic proliferation in the disc fibrocartilage might be similar to the chondrocytic proliferation within the articular cartilage of grade 3-4/6 knee osteoarthritis. (omicsonline.org)
  • Intervertebral disc is belonged to the kind of fibrocartilage, and composed of nucleus pulposus, i.e., a gelatin-like center, and annulus fibrosus, a thick capsule of air-bag-like structure. (omicsonline.org)
  • The end plate, a dense fibrocartilage interface, functions as a buffer between vertebral body and intervertebral disc, and may influence the nutrition support from verbebral capillaries [ 1 ]. (omicsonline.org)
  • Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions? (springer.com)
  • Kepler CK, Ponnappan RK, Tannoury CA, Risbud MV and Anderson DG: The molecular basis of intervertebral disc degeneration. (spandidos-publications.com)
  • Submit your Twitter account related to Intervertebral Disc Degeneration to be featured! (novusbio.com)
  • COLIA1 Sp1 polymorphism may be a genetic risk factor related to intervertebral disc degeneration in older people. (bmj.com)
  • The aim of this study was to determine the developmental origins of nucleus pulposus cells within the intervertebral disc using a novel notochord-specific Cre mouse. (biomedsearch.com)
  • It was determined that the pressure in the intervertebral disc is lowest in the supine position at 1 bar, whereas in the lateral position the pressure is slightly higher at 1.1 bar. (biosaffair.de)
  • It is also interesting that the pressure in the intervertebral disc rises during the night from 1 bar at the beginning of the resting phase up to 2.4 bar towards tomorrow, when the intervertebral disc accumulates with fluid again. (biosaffair.de)
  • Hence, it is important to understand the mechanical behavior of the intervertebral disc as a part of the entire spinal column in order to understand the etiology of spinal deformity. (scirp.org)
  • These both involve degeneration of intervertebral discs, but the mechanisms of degeneration and the predisposed breeds are different. (bowwowinsurance.com.au)
  • The possible causes of kyphosis are degeneration of intervertebral discs, development of vertebral fractures, and decrease in trunk muscle strength [9]. (scirp.org)
  • An artificial disc having a pair of opposing baseplates, for seating against opposing vertebral bone surfaces, separated by a ball and socket joint that includes a ball compression locked to a post extending from one of the baseplates. (google.com)
  • reported five-year results of an RCT that are consistent with the two-year results of noninferiority of Charité artificial discs compared to fusion. (ecri.org)
  • For those with progressive, severe and debilitating pain due to degenerating intervertebral discs, the only current option is major back surgery involving spinal fusion, artificial disc replacement, or other surgical procedures. (technologynetworks.com)
  • Le Maitre CL, Freemont AJ and Hoyland JA: Accelerated cellular senescence in degenerate intervertebral discs: A possible role in the pathogenesis of intervertebral disc degeneration. (spandidos-publications.com)
  • Herniated discs often cause nerve pain called sciatica that travels along the sciatic nerve, which runs from the lower back down the length of each leg. (medlineplus.gov)
  • The heat is intended to seal any ruptures in the disc wall and may also burn nerve endings, which can make the area less sensitive to pain. (wikipedia.org)
  • If a disc's outer layer breaks down and lets the soft inner core emerge, it results in a herniated or "slipped" disc and extra pressure is put on the spinal cord or spinal nerve roots. (reference.com)
  • Abe Y, Akeda K, An HS, Aoki Y, Pichika R, Muehleman C, Kimura T, Masuda K. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. (springer.com)
  • The bulging disc pressing against the spinal cord disrupts nerve signals to the limbs and bladder. (aspcapetinsurance.com)
  • Slipped Disk or Prolapsed Intervertebral Disc causes intense pain in back, legs & sciatic nerve. (hpathy.com)
  • Eventually, the outer disc layer ruptures acutely, allowing the calcified inner layer to press against the spinal cord, causing pressure, inflammation and nerve damage. (bowwowinsurance.com.au)
  • It has been demonstrated that disc degeneration impacts the adjacent nervous system structures, such as the nerve roots or the dorsal root ganglion (DRG). (aofoundation.org)
  • Objectives The aim of this study was to investigate whether whole-body vibration (WBV) is associated with prolapsed lumbar intervertebral disc (PID) and nerve root entrapment among patients with low-back pain (LBP) undergoing magnetic resonance imaging (MRI). (sjweh.fi)
  • It just means a piece of disc has ruptured through the back wall of the disc into the nerve canal and then migrated away to the extent it is no longer in contact with the disc. (healthtap.com)
  • A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve. (doereport.com)
  • During the procedure, a surgeon will remove the portion of the intervertebral disc that protrudes from the wall of the disc, along with any fragments that impinge on the spinal cord or nerve root. (marinahospital.com)
  • If a herniated disc causes nerve impingement leading to myelopathy symptoms, such as severe muscle weakness and/or bowel and urinary incontinence, then disk removal may be recommended. (marinahospital.com)
  • The nerve roots are also carefully retracted when the herniated disc is removed, using small grasping tools. (marinahospital.com)
  • The compression by the protruding disc on the dorsal and/or the ventral nerve roots causes low back pain, leg pain (sciatica), muscle spasm, and restriction of trunk movement [ 1 ]. (pubmedcentralcanada.ca)
  • One effect of aging and disc degeneration is that the nucleus pulposus begins to dehydrate and the concentration of proteoglycans in the matrix decreases, thus limiting the ability of the disc to absorb shock. (wikipedia.org)
  • This "gel" is made of water and proteoglycans, and it is the part of the disc that most absorbs and cushions your movements. (spineuniverse.com)
  • An analysis of proteoglycans of the intervertebral disc using immunoblotting of tissue extracts. (nih.gov)
  • Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. (nih.gov)
  • We sought to determine whether transplanted allogeneic bone mesenchymal stem cells can survive and increase the amount of proteoglycans in intervertebral discs. (nih.gov)
  • Most of these studies focused mainly on vertebral body stress rather than intervertebral disc pressure. (scirp.org)
  • The vertebral endplate is a plate of cartilage that acts as a barrier between the disc and the vertebral body. (physio-pedia.com)
  • CONCLUSIONS: We found that ICAM1 and other genes may play a role in the development of disc degeneration induced by inflammatory reactions using a bioinformatics analysis of the gene expression profiles of degenerative intervertebral disc cells stimulated with inflammatory factors, suggesting that bioinformatics methods can be used to identify potential target for intervertebral disc degeneration. (minervamedica.it)
  • 3- 6 The inverse relationship between osteoporosis and intervertebral disc degeneration may give insight into the pathogenesis of both disorders. (bmj.com)
  • Conclusions: The titanium intervertebral disc provides initial distraction of the fusioned segments with partial recurrence of kyphosis during the subsequent course. (osti.gov)
  • The intervertebral disc prosthesis according to claim 1, characterized in that: an angle formed between the plane of the upper and lower plates, such that the core (3) forms an acute angle along a front-to-rear direction (F). (google.com.au)
  • according to claim 2 intervertebral disc prosthesis, comprising: identical plates (1,2) with different thicknesses of the core ⑶ assembly. (google.com.au)
  • The intervertebral disc prosthesis according to claim 1, characterized in that: at least the upper plate (1) a portion of the lower surface (10) is concave, and the core (3) on the surface (31) up. (google.com.au)
  • The intervertebral disc prosthesis as claimed in claim 1, characterized in that: the size of each male means is slightly smaller than the size of each female means so as to be able to the core (3) and between the lower plate having a slight (2) clearance. (google.com.au)
  • any one of claims 1-7, intervertebral disc prosthesis, comprising: a lower plate O) devices are two male snap pin (20), the two snap pin bent toward the inside of the prosthesis and mutual Located opposite sides 01,22 of the prosthesis) and the core (3) of the female means is two recessed areas (30). (google.com.au)
  • The intervertebral disc prosthesis according to claim 8, characterized in that: the at least one snap pin 00) is provided with a bore (200) of the lug alternative, into the borehole using O00) of a pin 04) fixed to a tongue In the lug. (google.com.au)
  • A according to any one of claims 1-7 intervertebral disc prosthesis, comprising: a lower plate O) male means are located opposite each other on either side of the prosthesis 01,22) near the two walls, the core (3 ) The device is a concave recessed area. (google.com.au)
  • There is extrusion/prolapse of the intervertebral disc dorsally, causing compression of the spinal cord. (nih.gov)
  • There is dorsal extrusion of the intervertebral disc, with compression of the overlying spinal cord. (nih.gov)
  • In this section of vertebral column, there is degeneration of the nucleus pulposus and extrusion/prolapse of disc material. (nih.gov)
  • The methods comprise introducing an amount of the polyelectrolyte materials into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material. (google.co.uk)
  • These methods, although used by other researchers to measure surface strains on isolated discs, have not been applied to images of the disc's interior which is markedly inhomogeneous. (imechanica.org)
  • Once the methods have been developed they will be applied to 3D image data from human intervertebral discs acquired in vivo to begin to explore the normal variation in the patterns of strain distributions in discs as the subjects change posture and support load. (imechanica.org)
  • The end point of this project will be a suite of experimental and analytical methods validated for measurement of 3D strains in intervertebral discs in vivo, and publishable preliminary data on strain patterns in human subjects. (imechanica.org)
  • Intervertebral disc excision is performed when conservative treatment methods are unsuccessful in relieving back pain that persists for more than six weeks. (marinahospital.com)
  • Various analyses of the spinal column and intervertebral discs of astronauts clearly show that changes in intervertebral discs depend on their stress. (hslu.ch)
  • Changes in intervertebral disc (IVD) biochemistry, morphology and mechanics have been characterized only incompletely in the rat hindlimb unloading (HU) model. (suny.edu)
  • It is thought that discogenic pain from internal disc disruption accounts for the largest proportion of chronic low-back pain. (smore.com)
  • Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study. (nih.gov)
  • This article describes and discusses the case of an adolescent male with lumbar intervertebral disc injury characterized by chronic low back pain (LBP) and antalgia. (chiro.org)
  • There is a wide range of symptoms of intervertebral disc disorder in domestic dogs, varying from signs of mild neck or back pain to partial or complete paralysis. (bowwowinsurance.com.au)
  • An HS, Takegami K, Kamada H, Nguyen CM, Thonar EJ, Singh K, Andersson GB, Masuda K. Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. (springer.com)
  • The peer-reviewed publication showed that a single non-surgical injection of Mesoblast's allogeneic MPCs into damaged intervertebral discs resulted in significant regeneration of disc anatomy, increase in proteoglycan content, and increase in disc height, for at least six months. (technologynetworks.com)
  • During development and at birth, vertebral discs have some vascular supply to the cartilage endplates and the anulus fibrosus. (wikipedia.org)
  • 15 . The intervertebral prosthetic disc of claim 14 , wherein the biological factor is a bone morphogenetic protein (BMP), a cartilage-derived morphogenetic protein (CDMP), a platelet derived growth factor (PDGF), an insulin-like growth factor (IGF), a LIM mineralization protein, a fibroblast growth factor (FGF), an osteoblast growth factor, stem cells, or a combination thereof. (google.es)
  • But the genetic trait that makes them ground-hugging canines also affects cartilage growth (the main component of intervertebral discs) throughout their bodies. (aspcapetinsurance.com)
  • Plates of cartilage that bind the disc to their respective vertebral bodies. (physio-pedia.com)
  • To develop a classification system for lumbar disc degeneration based on routine magnetic resonance imaging, to investigate the applicability of a simple algorithm, and to assess the reliability of this classification system. (nih.gov)
  • A grading system for lumbar disc degeneration was developed on the basis of the literature. (nih.gov)
  • This retrospective study includes 53 patients who underwent reoperation after failure of lumbar disc surgery to relieve pain. (nih.gov)
  • Katz JN: Lumbar disc disorders and low-back pain: Socioeconomic factors and consequences. (spandidos-publications.com)
  • In the past decade, some scholars tested the stress and the strain in the intervertebral disc under load and analySed the interrelationship between the lumbar disc structure and its mechanical properties [ 14 - 18 ]. (alliedacademies.org)
  • Lumbar disc volume, anterior and posterior disc height, disc signal intensity, intervertebral length, and lordosis were measured on sagittal plane magnetic resonance images. (galileo-training.com)
  • Aoki Y, Takahashi Y, Ohtori S, Moriya H, Takahashi K. Distribution and immunocytochemical characterization of dorsal root ganglion neurons innervating the lumbar intervertebral disc in rats: a review. (springer.com)
  • The trial aims to extend Mesoblast's preclinical results, and show that a single MPC injection can reduce low back pain and improve function over six months, improve disc anatomy, and eliminate the need for a surgical procedure. (technologynetworks.com)
  • A healthy disc requires maintenance of a homeostatic environment, and when disrupted, a catabolic cascade of events occurs on a molecular level resulting in upregulation of proinflammatory cytokines, increased degradative enzymes, and a loss of matrix proteins. (springer.com)
  • In conclusion, miR‑148a inhibits pro‑inflammatory cytokines released by intervertebral disc cells via regulation of the p38/mitogen‑activated protein kinase pathway. (spandidos-publications.com)
  • To calculate intervertebral disc pressure in elderly women with kyphosis using a novel and precise thoracolumbar three-dimensional musculoskeletal model. (scirp.org)
  • The disc has 2 main parts: the annulus fibrosus and the nucleus pulposus . (spineuniverse.com)
  • The annulus fibrosus is the tougher outer layer of the disc. (spineuniverse.com)
  • An intervertbral disc can also herniate: the nucleus pulposus can start to push through the annulus fibrosus, causing a bulging disc. (spineuniverse.com)
  • If the nucleus pulposus pushes entirely though the annulus fibrosus, that is a herniated disc. (spineuniverse.com)
  • The outer layer, the annulus fibrosus, consists mainly of collagen I, and the interior structure of the disc, the nucleus pulposus, is about 50% proteoglycan, mainly aggrecan, and 20% collagen II. (sciencemag.org)
  • Each disc has a strong outer layer, called the annulus fibrosus, and a soft, jelly-like filling. (bowwowinsurance.com.au)
  • Clonal proliferation of chondrocytes over the areas other than endplate and outer rim of annulus fibrosus is a consistent phenomenon in all three groups of degenerative discs, and displaying lesser degree of chondrocytic proliferation among the HIVD cases without significant difference. (omicsonline.org)
  • The disc is innervated in the outer few millimetres of the annulus fibrosus [5] . (physio-pedia.com)
  • Hematoxylin and eosin staining and Masson staining revealed annulus fibrosus rupture, disordered arrangement, decreased nucleus pulposus tissue, and decreased collagen fiber in the rat intervertebral disc tissue. (springer.com)
  • The Intervertebral Disc (IVD) consists of the liquid Nucleus Pulposus (NP) surrounded by layers of the Annulus Fibrosus (AF) [ 12 , 13 ]. (alliedacademies.org)
  • The harvested disc material, which contains the nucleus pulposus and the anulus fibrosus were placed into the posterior epidural space at L4 of the same rabbit. (ovid.com)
  • The intervertebral disc functions to transmit mechanical loads arising from body weight and movement. (nih.gov)
  • In order to understand and describe the non-linear mechanical reactions of the intervertebral disc an axisymmetric finite element model has been built. (actapress.com)
  • This extreme low values of fluid compressibility amplify the disc height increase due to torsion The height increase due to torsion is important in everyday life disc mechanics because it may be related to the 'mechanical pumping' by the millions of small rotations experienced in life, that is likely to be vital for nutrition of the disc. (actapress.com)
  • Mechanical testing rigs will be used to apply known boundary conditions to homogenous phantom and real discs and image analysis will be used to determine the pattern of strain distribution in the discs. (imechanica.org)
  • The method is applied to the quantification of fluid redistribution in an intervertebral disc that deforms under mechanical load. (eur.nl)
  • The clinical importance of this application emerges from the increased susceptibility of the intervertebral disc to damage after a period of mechanical loading. (eur.nl)
  • Any disorder with the intervertebral disc. (smore.com)
  • What is intervertebral disc disorder with myelopathy lumbar region? (healthtap.com)
  • Is it possible to have cervical radiculopathy and intervertebral disc disorder with myelopathy cervical region? (healthtap.com)
  • Can cervical radiculopathy and intervertebral disc disorder with myelopathy, cervical region cause bladder problems? (healthtap.com)
  • Based on the information provided -- intervertebral disc disorder with myelopathy in the cervical region can cause bladder dysfunction as the spinal cord is compressed by the disc. (healthtap.com)
  • 2 . A prosthetic disc as in claim 1 , wherein at least one of the curved surfaces is spherical. (google.co.uk)
  • 3 . A prosthetic disc as in claim 2 , wherein both curved surfaces are spherical. (google.co.uk)
  • 4 . A prosthetic disc as in claim 1 , wherein movement of the core within the peripheral restraining structure is unconstrained. (google.co.uk)
  • 5 . A prosthetic disc as in claim 1 , wherein the peripheral restraining structure defines a stop structure to limit relative inclination of the plates during sliding movement of the plates over the core. (google.co.uk)
  • 6 . A prosthetic disc as in claim 1 , wherein the peripheral restraining structure will engage one side of the core to lift an opposite side of the core during sliding movement of the plates over the core. (google.co.uk)
  • 8 . A prosthetic disc as in claim 7 , wherein the ring structure comprises a flange which defines an overhang, and wherein at least part of the annular structure on the core extends into the overhang to provide an interference fit of the core with the flange. (google.co.uk)
  • 9 . A prosthetic disc as in claim 8 , wherein the annular structure comprises a rim which extends continuously around a lateral circumference of the core, the rim having a greater width at at least some locations than a width of an inner edge of the flange to provide said interference fit. (google.co.uk)
  • 11 . A prosthetic disc as in claim 10 , wherein the lip extends into the groove to form an interference fit between the ring structure and the core. (google.co.uk)
  • 13 . A prosthetic disc as in claim 12 , wherein the at least one surface feature comprises a plurality of serrations disposed along the outer surfaces. (google.co.uk)
  • 14 . A prosthetic disc as in claim 13 , wherein the at least one surface feature further comprises a surface coating. (google.co.uk)
  • 15 . A prosthetic disc as in claim 14 , wherein the surface coating comprises plasma sprayed titanium. (google.co.uk)
  • 2 . The intervertebral prosthetic disc of claim 1 , wherein the first compliant layer is at least partially convex. (google.es)
  • 3 . The intervertebral prosthetic disc of claim 1 , wherein the first compliant layer has a substantially uniform thickness. (google.es)
  • 5 . The intervertebral prosthetic disc of claim 1 , wherein the first compliant layer comprises an extended use biocompatible material. (google.es)
  • 6 . The intervertebral prosthetic disc of claim 5 , wherein the extended use biocompatible material is a synthetic polymer, a natural polymer, a bioactive ceramic, compression molded carbon nanofibers, or a combination thereof. (google.es)
  • 7 . The intervertebral prosthetic disc of claim 6 , wherein the synthetic polymer is a polyurethane material, a polyolefin material, a polyether material, a polyester material, a polycarbonate material, a silicone material, a hydrogel material, or a combination thereof. (google.es)
  • 8 . The intervertebral prosthetic disc of claim 7 , wherein the polyolefin material is polypropylene, polyethylene, halogenated polyolefin, flouropolyolefin, or a combination thereof. (google.es)
  • 9 . The intervertebral prosthetic disc of claim 7 , wherein the polyether material is polyetherketone (PEK), polyetheretherketone (PEEK), polyetherketoneketone (PEKK), polyaryletherketone (PAEK), or a combination thereof. (google.es)
  • 10 . The intervertebral prosthetic disc of claim 7 , wherein the polyester material is polylactide. (google.es)
  • 11 . The intervertebral prosthetic disc of claim 7 , wherein the polycarbonate material is tyrosine polycarbonate. (google.es)
  • 13 . The intervertebral prosthetic disc of claim 6 , wherein the bioactive ceramic is hydroxyapatite (HA), hydroxyapatite tricalcium phosphate (HATCP), calcium phosphate, calcium sulfate, or a combination thereof. (google.es)
  • 14 . The intervertebral prosthetic disc of claim 1 , wherein the superior compliant layer, the inferior compliant layer, or a combination thereof includes a biological factor to promote bone growth. (google.es)
  • 16 . The intervertebral prosthetic disc of claim 15 , wherein the stem cells include bone marrow derived stem cells, lipo derived stem cells, or a combination thereof. (google.es)
  • We used the rabbit intervertebral disc as a model, creating three groups: an uninjected control group, a group injected with saline, and a group injected with 1 x 10(5) of bone mesenchymal stem cells containing trace marker gene LacZ from young rabbits. (nih.gov)
  • Our data suggest transplanted allogenic bone mesenchymal stem cells can survive and increase proteoglycan amount, supporting its potential use as a treatment of intervertebral disc degeneration. (nih.gov)
  • Akmal M, Kesani A, Anand B, Singh A, Wiseman M, Goodship A. Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration. (springer.com)
  • The centre of the disc is formed of cells and a gel-like matrix, called the nucleus pulposus. (sciencephoto.com)
  • Physical exercise has a positive effect on the formation of cells in the intervertebral discs. (medicalxpress.com)
  • The study from the Sahlgrenska Academy shows that physical activity has a positive effect on cells in the intervertebral discs. (medicalxpress.com)
  • It was subsequently studied how many new cells in the intervertebral discs were formed in rats that had run on a treadmill for about one hour a day compared with animals that had only moved around freely in a cage. (medicalxpress.com)
  • Based on the results of the study, the research team led by Helena Brisby and Björn Rydevik intends to go on to study whether the cells in degenerated discs respond as positively to exercise as they have now shown to do in normal discs. (medicalxpress.com)
  • Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. (biomedsearch.com)
  • To trace the fate of notochordal cells within the intervertebral disc, we derived a notochord-specific Cre mouse line by targeting the homeobox gene Noto. (biomedsearch.com)
  • These studies establish conclusively that notochordal cells act as embryonic precursors to all cells found within the nucleus pulposus of the mature intervertebral disc. (biomedsearch.com)
  • This suggests that notochordal cells might serve as tissue-specific progenitor cells within the disc and establishes the Noto-cre mouse as a unique tool to interrogate the contribution of notochordal cells to both intervertebral disc development and disc degeneration. (biomedsearch.com)
  • NEW YORK and MELBOURNE, Australia, April 22, 2013 (GLOBE NEWSWIRE) -- Regenerative medicine company Mesoblast Limited (ASX:MSB) (USOTC:MBLTY) today announced that all 100 patients in its Phase 2 clinical trial of its proprietary Mesenchymal Precursor Cells (MPCs) for intervertebral disc repair had completed six months of follow-up, the endpoint at which data will be evaluated for progression to Phase 3. (globenewswire.com)
  • Gruber HE, Ingram JA, Norton HJ and Hanley EN Jr: Senescence in cells of the aging and degenerating intervertebral disc: Immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. (spandidos-publications.com)
  • Human intervertebral disc (hIVD) cells were isolated from 41 surgically excised samples and assessed for their phenotypic alterations with age. (ovid.com)
  • Furthermore, a positive correlation was observed between the SDF-1 IOD value and the percentage of CXCR4-positive disc cells in the nucleus pulposus and cartilaginous endplate. (medsci.org)
  • However, little is known about the origin of newly formed vessels and inflammatory cells detected in herniated disc specimens from patients. (ovid.com)
  • In particular, cells from degenerate discs exhibited increased SA-β-gal activity, elevated expression of the cell cycle inhibitor p16 INK4a , telomere erosion, and a decrease in replicative potential. (springermedizin.de)
  • Mesoblast Limited has announced that its Phase 2 clinical trial investigating the use of allogeneic, or off-the-shelf, Mesenchymal Precursor Cells (MPCs) for non-surgical restoration of degenerated intervertebral discs and treatment of low back pain has enrolled 50% of the total study patients. (technologynetworks.com)
  • Aged and degenerated intervertebral discs are characterised by a significant increase in the number of senescent cells, which may be associated with the deterioration of this tissue due to their catabolic phenotype. (ecmjournal.org)
  • There was a significant difference in cellular MMP28 distribution in the disc (P = 0.008): the outer annulus showed the largest percentage of cells positive for MMP28 immunolocalization, followed by the inner annulus and then the nucleus. (eurekamag.com)
  • Herniated discs showed a significantly greater proportion of MMP28-positive cells compared with nonherniated discs (P = 0.034). (eurekamag.com)
  • The purpose of the study was to identify the key genes that were differentially expressed in these disc cells compared to cells without inflammatory cytokine treatment, using bioinformatics analyses, and to explore the related signaling pathways and interaction networks, providing clues to the molecular mechanisms of disc degeneration for future experimental studies. (minervamedica.it)
  • Mesenchymal progenitor cells primed with pentosan polysulfate promote lumbar intervertebral disc. (deepdyve.com)
  • In healthy patients, this corresponds to the size of the intervertebral disc. (wikipedia.org)
  • The reliability of the algorithm in depicting intervertebral disc alterations was tested on the magnetic resonance images of 300 lumbar intervertebral discs in 60 patients (33 men and 27 women) with a mean age of 40 years (range, 10-83 years). (nih.gov)
  • Patients who had past or pending compensation claims, who had sensory loss involving more than one dermatome, or who failed to have myelographic dural sac indentations resembling those caused by a herniated disc did poorly with reoperation. (nih.gov)
  • A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians because it may help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies. (springer.com)
  • More research is needed regarding long-term implications of such disc injuries in young people, and how to best conservatively manage these patients. (chiro.org)
  • Measurements of the intervertebral disc space were made by magnetic resonance imaging and plain film examinations over a period of 2 years in 26 patients who had undergone chemonucleolysis. (osti.gov)
  • misc{etde_6737010, title = {Changes seen on magnetic resonance imaging in the intervertebral disc space after chemonucleosis: a hypothesis concerning regeneration of the disc after chemonucleosis} author = {Kato, F, Mimatsu, K, Kawakami, N, and Miura, T} abstractNote = {Measurements of the intervertebral disc space were made by magnetic resonance imaging and plain film examinations over a period of 2 years in 26 patients who had undergone chemonucleolysis. (osti.gov)
  • Patients were randomized to receive direct intra-disc injection of saline (n= 20), hyaluronic acid (HA, n=20), 6 million MPCs in hyaluronic acid carrier (6M, n=30) or 18 million MPCs in hyaluronic acid carrier (18M, n=30). (globenewswire.com)
  • Clinical effects of acupuncture following surgery in patients with prolapse of lumbar intervertebral disc, by Zhao Bin‑xiu et al. (jcm.co.uk)
  • Patients undergoing intervertebral disc excision will be allowed to return to home on the same day or the day following their procedure. (marinahospital.com)
  • Mesoblast is developing a non-surgical adult stem cell treatment for these patients using a simple intervertebral disc injection of allogeneic MPCs that takes less than 15 minutes in an outpatient setting. (technologynetworks.com)
  • Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation. (nih.gov)
  • 4. The method of claim 1 or 3 wherein removing the material comprises removing disc tissue. (google.es)
  • Growth, aging, and degeneration of the intervertebral disc are associated with changes in the abundance and structure of fibromodulin and lumican, which presumably influence the functional properties of the tissue. (nih.gov)
  • What kind of tissue makes up the intervertebral discs? (reference.com)
  • An alternate protocol is presented for gradient recalled echo acquisitions that may be used in the sagittal and/or transverse planes to clearly distinguish between discs and soft tissue and to clarify the spinal neural foramen in the cervical region. (currentprotocols.com)
  • The disc is found between two vertebral bodies their bone tissue margins stained pink. (sciencephoto.com)
  • The intervertebral disc can be affected primarily by damaging or loss of organ tissue or, secondarily, through metabolic, immunological or biomechanical changes, such as segmental instability with subsequent damage the disc organ. (wheelessonline.com)
  • We suspect that the disc degenerated markedly after chemonucleolysis and changed into a type of scar tissue, maturation of which could stabilize the affected segment. (osti.gov)
  • Autologous intervertebral disc material grafted into the epidural space was penetrated by newly formed vessels produced from the epidural fat tissue and resolved as the result of inflammatory reaction. (ovid.com)
  • Pathological changes in rat intervertebral disc tissue were observed by hematoxylin and eosin staining and Masson staining. (springer.com)
  • Rat intervertebral disc tissue showed decreased GAG, CS-KS, and (HA) contents, increased type I collagen levels, and decreased type II collagen levels in degenerated intervertebral discs. (springer.com)
  • These results demonstrate that intervertebral disc degeneration is associated with tissue fibrosis. (springer.com)
  • Degeneration of intervertebral disc tissue may occur after injury, causing neurological disorders including low back pain. (springer.com)
  • The intervertebral disc is a cartilaginous joint between adjacent vertebral bodies and a complex structural tissue with multiple components. (springer.com)
  • On the other hand, carboxymethyl-lysine has been found to be accumulated with ageing in the proteins of the disc, evidencing the existence of oxidative stress in this tissue. (ecmjournal.org)
  • Gene expression levels in human disc tissue were detectable for both MMP28 and the MMP28 precursor. (eurekamag.com)
  • Our data, which show the presence of MMP28 in human disc tissue, suggest that MMP28 may have a potentially important role in ECM modulation in the healthy and degenerating disc. (eurekamag.com)
  • Disc height was decreased after injection with HTRA1 and was significantly correlated with changes in GAG/DNA of the NP tissue. (uzh.ch)
  • The nucleus pulposus of the disc functions to distribute hydraulic pressure in all directions within each intervertebral disc under compressive loads. (wikipedia.org)
  • The disc is subjected to various loads, including compressive, tensile and shear stresses [10] [11] . (physio-pedia.com)
  • These results imply that suppressing pro-inflammatory events in the disc by either augmenting anti-inflammatory events or suppressing production of pro-inflammatory molecules or both may form a logical step in the prevention and management of IVD degeneration. (portlandpress.com)
  • It has been shown that inflammatory factors may play an important role in the mechanism of resorption of the herniated intervertebral disc. (ovid.com)
  • Ma J, Stefanoska D, Hildebrand M, Zeiter S, Alini M, Peroglio M. Validation of cell line models to study intervertebral disc neo-innervation associated with discogenic pain. (aofoundation.org)
  • A discussion of discogenic LBP pertaining to adolescent disc injury is included. (chiro.org)