Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A type of CARTILAGE whose matrix contains large bundles of COLLAGEN TYPE I. Fibrocartilage is typically found in the INTERVERTEBRAL DISK; PUBIC SYMPHYSIS; TIBIAL MENISCI; and articular disks in synovial JOINTS. (From Ross et. al., Histology, 3rd ed., p132,136)
The spinal or vertebral column.
The dissolving of the nucleus pulposus, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
Excision, in part or whole, of an INTERVERTEBRAL DISC. The most common indication is disk displacement or herniation. In addition to standard surgical removal, it can be performed by percutaneous diskectomy (DISKECTOMY, PERCUTANEOUS) or by laparoscopic diskectomy, the former being the more common.
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
Region of the back including the LUMBAR VERTEBRAE, SACRUM, and nearby structures.
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.
A group of twelve VERTEBRAE connected to the ribs that support the upper trunk region.
Inflammation of an INTERVERTEBRAL DISC or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
X-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.
Glycoproteins which have a very high polysaccharide content.
Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
Percutaneous excision of a herniated or displaced INTERVERTEBRAL DISC by posterolateral approach, always remaining outside the spinal canal. Percutaneous nucleotomy was first described by Hijikata in Japan in 1975. In 1985 Onik introduced automated percutaneous nucleotomy which consists in percutaneous aspiration of the nucleus pulposus. It is carried out under local anesthesia, thus reducing the surgical insult and requiring brief hospitalization, often performed on an outpatient basis. It appears to be a well-tolerated alternative to surgical diskectomy and chymopapain nucleolysis.
Forward displacement of a superior vertebral body over the vertebral body below.
Narrowing of the spinal canal.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.
A dead body, usually a human body.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
The replacement of intervertebral discs in the spinal column with artificial devices. The procedure is done in the lumbar or cervical spine to relieve severe pain resulting from INTERVERTEBRAL DISC DEGENERATION.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
The cavity within the SPINAL COLUMN through which the SPINAL CORD passes.
Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Polymorphic cells that form cartilage.
A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)
A small leucine-rich proteoglycan found in a variety of tissues including CAPILLARY ENDOTHELIUM; SKELETAL MUSCLE; CARTILAGE; BONE; and TENDONS. The protein contains two glycosaminoglycan chains and is similar in structure to DECORIN.
Injuries involving the vertebral column.
An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
A computer based method of simulating or analyzing the behavior of structures or components.
Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.
An anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain.
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.
The anterior concavity in the curvature of the lumbar and cervical spine as viewed from the side. The term usually refers to abnormally increased curvature (hollow back, saddle back, swayback). It does not include lordosis as normal mating posture in certain animals ( = POSTURE + SEX BEHAVIOR, ANIMAL).
Internal devices used in osteosynthesis to hold the position of the fracture in proper alignment. By applying the principles of biomedical engineering, the surgeon uses metal plates, nails, rods, etc., for the correction of skeletal defects.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
The joint that occurs between facets of the interior and superior articular processes of adjacent VERTEBRAE.
The physiological renewal, repair, or replacement of tissue.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A type II keratin found associated with KERATIN-18 in simple, or predominately single layered, internal epithelia.
Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Space between the dura mater and the walls of the vertebral canal.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Deficient development or degeneration of a portion of the VERTEBRA, usually in the pars interarticularis (the bone bridge between the superior and inferior facet joints of the LUMBAR VERTEBRAE) leading to SPONDYLOLISTHESIS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.
Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film).
Surgical insertion of a prosthesis.
The pull on a limb or a part thereof. Skin traction (indirect traction) is applied by using a bandage to pull on the skin and fascia where light traction is required. Skeletal traction (direct traction), however, uses pins or wires inserted through bone and is attached to weights, pulleys, and ropes. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed)
A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; COSTAL CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A plate of fibrous tissue that divides the temporomandibular joint into an upper and lower cavity. The disc is attached to the articular capsule and moves forward with the condyle in free opening and protrusion. (Boucher's Clinical Dental Terminology, 4th ed, p92)
A growth differentiation factor that plays a role in early CHONDROGENESIS and joint formation.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

A comparative chemical and histochemical study of the chondrodystrophoid and nonchondrodystrophoid canine intervertebral disc. (1/1257)

The chemical composition of the intervertebral disc of 9-month-old chondrodystrophoid and nonchondrodystrophoid dogs was studied for collagen, noncollagenous protein and glycosaminoglycan. Content of these substances differed significantly between breeds. The differences were most marked in the nucleus pulposus; the noncollagenous protein content of the nonchondrodystrophoid breed was higher than in that of the chondrodystrophoid dogs. The total nitrogen value of the nonchondrodystrophoid nuclei pulposi was less than that of the corresponding chondrodystrophoid discs mainly because of the high collagen content of the latter discs. Histochemically, it was found that the nuclei pulposi of the nonchondrodystrophoid breed contains larger amounts of glycosaminoglycan than in the discs of the chondrodystrophoid breeds.  (+info)

Extradural inflammation associated with annular tears: demonstration with gadolinium-enhanced lumbar spine MRI. (2/1257)

Annular tears are manifest on MRI as the high-intensity zone (HIZ) or as annular enhancement. Patients with annular tears may experience low back pain with radiation into the lower limb in the absence of nerve root compression. Inflammation of nerve roots from leak of degenerative nuclear material through full-thickness annular tears is a proposed mechanism for such leg pain. The aim of this study is to illustrate the appearance of extradural enhancement adjacent to annular tears in patients being investigated for low back pain with radiation into the lower limb(s). Sagittal T1- and T2-weighted spin echo and axial T1-weighted spin echo sequences were obtained in eight patients being investigated for low back and leg pain. In all patients, the T1-weighted sequences were repeated following intravenous gadopentetate dimeglumine (Gd-DTPA). Annular tears were identified at 12 sites in eight patients. Extradural inflammation appeared as a region of intermediate signal intensity replacing the fat between the posterior disc margin and the theca, which enhanced following Gd-DTPA. The inflammatory change was always associated with an annular tear, and in four cases directly involved the nerve root. Enhancement of the nerve root was seen in two cases. The findings may be relevant in the diagnosis of chemical radiculopathy secondary to inflammation at the site of an annular leak from a degenerating disc.  (+info)

A clinico-pathological study of cervical myelopathy in rheumatoid arthritis: post-mortem analysis of two cases. (3/1257)

Two patients who developed cervical myelopathy secondary to rheumatoid arthritis were analyzed post mortem. One patient had anterior atlanto-axial subluxation (AAS) combined with subaxial subluxation (SS), and the other had vertical subluxation (VS) combined with SS. In the patient with AAS, the posterior aspect of the spinal cord demonstrated severe constriction at the C2 segment, which arose from dynamic osseous compression by the C1 posterior arch. A histological cross-section of the spinal cord at the segment was characterized by distinct necrosis in the posterior white columns and the gray matter. In the patient with VS, the upper cervical cord and medulla oblongata showed angulation over the invaginated odontoid process, whereas no significant pathological changes were observed. At the level of SS, the spinal cord was pinched and compressed between the upper corner of the vertebral body and the lower edge of the lamina. Histologically, demyelination and gliosis were observed in the posterior and lateral white columns.  (+info)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (4/1257)

The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up.  (+info)

Cervical spondylotic myelopathy in elderly people: a high incidence of conduction block at C3-4 or C4-5. (5/1257)

OBJECTIVES: To precisely localise the site of conduction block in elderly patients with cervical spondylotic myelopathy in the presence of multilevel compression shown by MRI. METHODS: A total of 44 patients aged 65 and older underwent serial intervertebral recording of spinal somatosensory evoked potentials (SSEPs) from either the intervertebral disc or the ligamentum flavum after epidural stimulation. The site of conduction block identified by abrupt reduction in size of the negative peak was designated as the 0 level with the other levels numbered in order of distance assigning a minus sign caudally. RESULTS: A single site of focal conduction block was disclosed in 42 patients, 23 (55%) at C3-4, 17 (40%) at C4-5, and two (5%) at C5-6. At these levels (0), the amplitude of the negative component was reduced (p<0.0001) to 29% and the area to 22%, with a concomitant increase (p<0.0001) of the initial positive component to 150% in amplitude and 293% in area as compared to the-2 level which was taken as the baseline (100%). CONCLUSIONS: A high incidence (95%) of focal conduction block at C3-4 or C4-5 with normal conduction at C5-6 and C6-7 characterises cervical spondylotic myelopathy in elderly people. Incremental SSEP studies documenting the site of conduction block will help exclude clinically silent cord compression, directing the surgical intervention to the appropriate level of concern.  (+info)

Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases. (6/1257)

The MR imaging findings of fungal spinal osteomyelitis in three recipients of organ transplants showed hypointensity of the vertebral bodies on T1-weighted sequences in all cases. Signal changes and enhancement extended into the posterior elements in two cases. Multiple-level disease was present in two cases (with a total of five intervertebral disks involved in three cases). All cases lacked hyperintensity within the disks on T2-weighted images. In addition, the intranuclear cleft was preserved in four of five affected disks at initial MR imaging. MR features in Candida and Aspergillus spondylitis that are distinct from pyogenic osteomyelitis include absence of disk hyperintensity and preservation of the intranuclear cleft on T2-weighted images. Prompt recognition of these findings may avoid delay in establishing a diagnosis and instituting treatment of opportunistic osteomyelitis in the immunocompromised patient.  (+info)

Lumbar intradiscal pressure after posterolateral fusion and pedicle screw fixation. (7/1257)

In vitro biomechanical testing was performed in single-functional spinal units of fresh calf lumbar spines, using pressure needle transducers to investigate the effect of posterolateral fusion (PLF) and pedicle screw constructs (PS) on intradiscal pressure (IDP), in order to elucidate the mechanical factors concerned with residual low back pain after PLF. IDP of 6 calf lumbar spines consisting of L4 and L5 vertebrae and an intervening disc was measured under axial compression, flexion-extension and lateral bending in the intact spine, PS, PLF and the destabilized spine. Relative to the intact spines, the destabilized spines showed increased IDP in all of lordings and moments. IDP under PS and PLF were significantly decreased in axial compression, extension and lateral bending loads (p<0.05). In flexion, IDP under PS and PLF increased linearly proportional to the magnitude of flexion moment and reached as high as IDP of the intact spines. These results demonstrated that despite an increase in the stiffness of motion segments after PLF and PS, significant high disc pressure is still generated in flexion. Flexibility of PS and PLF may cause increased axial load sharing of the disc in flexion and increased IDP. This high IDP may explain patients' persisting pain following PS and PLF.  (+info)

Relationship of pain drawings to invasive tests assessing intervertebral disc pathology. (8/1257)

It has been found that the pain patterns in pain drawings are related to the presence of herniated disc identified by myelography. The purpose of this study was to determine whether the pattern of pain in the drawings or the type of pain indicated (aching, burning, numbness, pins and needles, stabbing) was related to the presence of symptomatic disc pathology identified by CT/discography. In a subgroup of patients who underwent myelography, the relationship of the drawings to myelographic findings was also investigated. Pain drawings were completed by 187 patients with low back and/or radicular pain who were undergoing CT/discography. The drawings were scored in two ways, first by the system described by Ransford and secondly by visual inspection. They were classified as being indicative, or not, of disc pathology. The CT/discograms were classified as disrupted, or not, and the pain responses were recorded upon injection of each disc, based on the similarity of the pain provoked to clinical symptoms. Among the 133 patients with discogenic pain confirmed by discography, 110 (82.7%) had pain drawings that were classified as indicative. Among the 45 patients without discogenic pain, 29 (64.4%) had pain drawings classified as non-indicative. Patients with discogenic pain used more symbols indicating burning pain and aching pain than did non-discogenic pain patients. Our results confirmed those reported earlier by Uden, who found a relationship between the pattern of pain in the drawings and myelographic findings. Pain drawings may be helpful in the diagnosis of symptomatic disc pathology.  (+info)

Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a continuous measure has made it difficult to sensitively examine degenerative disc disease. This study sought to examine the relationship between disc degeneration and intervertebral disc height. 72 community-based individuals not selected for low back pain had MRI from which the presence of lumbosacral disc degeneration was identified using the Pfirrmann grading system, and intervertebral disc height was measured. At each lumbosacral level, with higher grade of disc degeneration, intervertebral disc height was reduced (all p ≤ 0.003). Results remained unchanged when grade 5 disc degeneration, which necessitated a collapsed disc space, was excluded from analyses (all p ≤ 0.03). To quantify these
TY - JOUR. T1 - The interaction between co-cultured human nucleus pulposus cells and mesenchymal stem cells in a bioactive scaffold. AU - Wu, Chang Chin. AU - Yang, Shu Hua. AU - Huang, Teng Le. AU - Liu, Chia Ching. AU - Lu, Dai Hua. AU - Yang, Kai Chiang. AU - Lin, Feng Huei. PY - 2012/6. Y1 - 2012/6. N2 - Mesenchymal stem cells (MSCs) can differentiate into nucleus pulposus (NP) cells upon being co-cultured with NP cells. Important growth factors and morphogens secreted by MSCs during the differentiation process also enhance the biological properties of NP cells. In this study, the interactions between human NP cells and MSCs co-cultured in different cell-ratio (100% NP, 75% NP with 25% MSCs, 50% NP with 50% MSCs, 25% NP with 75% MSCs, and 100% MSCs) in a three-dimensional gelatin/chondroitin-6-sulfate/hyaluronan tri-copolymer scaffold were examined. Results showed that the cell proliferation was increased when NP and MSCs were co-cultured. Real-time PCR and immunohistochemical staining ...
The aim of this study was to determine if treatment with reversine, a purine analog, promoted generation of skeletal progenitor cells from lineage-committed annulus fibrosus cells. Reversine modulated cell growth, morphology, and the actin cytoskeleton of annulus fibrosus cells. Microarray profiling coupled with Ingenuity Pathway Analysis revealed that reversine treatment resulted in a significant expression change in many genes including those required for cell-cell interaction, cell movement, cell growth, and development. Further analysis revealed that there was involvement of gene networks concerned with cellular assembly and organization, DNA replication and repair, tissue morphology, and cell-to-cell signaling. The gene expression profile was dependent on reversine concentration. In osteogenic media, cells pretreated with 300nM reversine exhibited an increased induction in alkaline phosphatase activity and enhanced expression of alkaline phosphatase, bone sialoprotein, osteocalcin, and ...
Also known as: Disc Herniation, Lumbar / Lumbar Disc Herniations / Lumbar Disc Herniation / Prolapsed lumbar intervertebral disc (disorder) / Prolapsed lumbar intervertebral disc / Slipped lumbar disc / Intervertebral disc extrusion / Herniated disk NOS / Herniated disc / Intervertebral disc prolapse (disorder) / Slipped disc / (Intervertebral disc disorders (& [prolapsed] or [slipped]) or (disc lesion: [spine] or [cervical] or [lumbar] or [thoracic]) or (postlaminectomy syndrome) / Intervertebral disc protrusion / Intervertebral disc herniation / Prolapsed disc NOS / Intervertebral disc prolapse NOS (disorder) / (Disc displacement, site unspecified, without myelopathy) or (intervertebral disc prolapse: [NOS] or [without myelopathy]) / Intervertebral disc prolapse / Intervertebral disc bulging / (Intervertebral disc: [disorders] or [displacement] or [slipped]) or (acute back pain) ...
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification.. Main Body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue ...
Human Nucleus Pulposus Cell MicroRNA https://www.sciencepro.com.br/produtos/sc-4807 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
TY - JOUR. T1 - Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. AU - Kim, Hyang. AU - Lee, Jeong Uk. AU - Moon, Seong Hwan. AU - Kim, Hyung Chan. AU - Kwon, Un Hae. AU - Seol, Nam Hun. AU - Kim, Ho Joong. AU - Park, Jin Oh. AU - Chun, Heoung Jae. AU - Kwon, Il Keun. AU - Lee, Hwan Mo. PY - 2009/8. Y1 - 2009/8. N2 - Study Design.: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucleus pulposus (NP), transitional zone (TZ), and anulus fibrosus (AF) of the human intervertebral disc (IVD). Objective.: To demonstrate the differential effect of BMP-2 on DNA synthesis, proteoglycan synthesis, and osteocalcin mRNA expression in human IVD cells from the NP, TZ, and AF, respectively. Summary of Background Data.: BMP-2 has been proven to be effective in stimulating proteoglycan synthesis in articular chondrocytes and IVD cells from the NP. Nevertheless, the effect of BMP-2 on cells from different regions of the IVD has not yet been ...
The intervertebral disc (IVD) is one of the bodys most important load-bearing structures with the major mechanical force experienced in the nucleus pulposus (NP) being hydrostatic pressure (HP). Physiological levels of HP have an anabolic effect on IVD matrix metabolism in cells derived from non-degenerate animal and herniated IVD while excessive HP has a catabolic effect. However, no studies have investigated the response of non-degenerate and degenerate human disc cells derived from non-herniated discs to HP. Here we investigate the effect of physiological HP on such cells using a novel loading rig. Human IVD cells (both NP and AF) cultured in alginate were subjected to dynamic HP (0.8-1.7 MPa 0.5 Hz) for 2 h. Cell viability was assessed, RNA extracted and qRT-PCR for 18 s, c-fos, Sox-9, collagen type II, aggrecan and MMP-3 performed. Cell viability was unaffected by the loading regime. In non-degenerate NP cells, HP increased c-fos, aggrecan, Sox-9 and collagen type II (significantly so in ...
STUDY DESIGN: Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6, prostaglandin E2, and matrix metalloproteinases. The effects of endogenously produced nitric oxide on the synthesis of other mediators also were studied.. OBJECTIVES: To test the hypothesis that the cells of the intervertebral disc are metabolically active and are capable of responding to biochemical stimuli such as interleukin-1 beta in a manner that could engender degenerative changes. As part of this study, the authors also investigated some of the possible autocrine regulatory mechanisms that may operate during the biochemical responses of disc cells.. SUMMARY OF BACKGROUND DATA: The authors previously showed, for the first time, that herniated cervical and lumbar disc specimens spontaneously produce increased amounts of nitric oxide, interleukin-6, prostaglandin E2, and certain matrix metalloproteinases. These ...
The present disclosure is directed to methods for relieving pain associated with an intervertebral disc having a disc nucleus pulposus and an outer annulus fibrosus surrounding the nucleus pulposus. The method includes the steps of providing an elongated thermal or electromagnetic probe member having a flexible guidable region adjacent the distal end thereof; introducing the flexible guidable region of the probe into the annulus fibrosus of the intervertebral disc; and supplying thermal or electromagnetic energy, from an energy source, to heat or induce an electromagnetic field adjacent to the annulus fibrosus sufficient to produce a thermal or electromagnetic effect on the intervertebral disc. The flexible guidable region of the probe may be introduced at a location which is in relative close proximity to the region of intervertebral disc to be thermally or electromagnetically treated.
Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease process are still not well understood. In this study, we sought to determine whether MMP-2 is associated with degenerative changes in the AF and to identify the manner by which AF cells use MMP-2. Two established animal models of disc degeneration, static compression and transannular needle puncture of rodent caudal discs, were examined for MMP-2 immunopositivity. With lentiviral transduction of an shRNA expression cassette, we screened and identified an effective shRNA sequence for generating stable RNA interference to silence MMP-2 expression in primary rat AF cells. Gelatin films were used to compare gelatinase activity and spatial patterns of degradation between transduced cells, and both
TY - JOUR. T1 - Tissue engineering of the intervertebral disc with cultured nucleus pulposus cells using atelocollagen scaffold and growth factors. AU - Lee, Kwang Il. AU - Moon, Seong Hwan. AU - Kim, Hyang. AU - Kwon, Un Hye. AU - Kim, Ho Joong. AU - Park, Si Nae. AU - Suh, Hwal. AU - Lee, Hwan Mo. AU - Kim, Hak Sun. AU - Chun, Heoung Jae. AU - Kwon, Il Keun. AU - Jang, Ju Woong. PY - 2012/3/15. Y1 - 2012/3/15. N2 - Study Design.: In vitro experiment using rabbit nucleus pulposus (NP) cells seeded in atelocollagen scaffolds under the stimulation of growth factors. Objective.: To demonstrate the effect of anabolic growth factors in rabbit NP cells cultured in atelocollagen type I and type II. Summary of Background Data.: Atelocollagen provides intervertebral disc (IVD) cells for a biocompatible environment to produce extracellular matrix. IVD cells with exogenous transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2) also render an increase in matrix synthesis. ...
To read the full abstract subscribe to the JCM online archive.. Clinical effects of acupuncture following surgery in patients with prolapse of lumbar intervertebral disc, by Zhao Bin‑xiu et al. Prolapse of the lumbar intervertebral discs is clinically common. The ... SKU: a1145. ...
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks. Viability of native NP cells and delivered MSCs was maintained. Furthermore hMSCs delivered via the L-pNIPAM-co-DMAc hydrogel differentiated and produced NP matrix components: aggrecan, collagen type II and chondroitin sulphate, with integration of the hydrogel with native NP tissue. In addition L-pNIPAM-co-DMAc hydrogel injected into ...
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration. Here we identify populations of progenitor cells that are Tie2 positive (Tie2+) and disialoganglioside 2 positive (GD2+), in the nucleus pulposus from mice and humans. These cells form spheroid colonies that express type II collagen and aggrecan. They are clonally multipotent and differentiated into mesenchymal lineages and induced reorganization of nucleus pulposus tissue when transplanted into non-obese diabetic/severe combined immunodeficient mice. The frequency of Tie2+ cells in tissues from patients decreases markedly with age and degeneration of the intervertebral disc, suggesting exhaustion of their capacity for regeneration. However, progenitor cells (Tie2+GD2+) can be induced from their precursor cells (Tie2+GD2-) under simple culture conditions. Moreover, angiopoietin-1, a ligand of Tie2, is
TY - JOUR. T1 - ATP promotes extracellular matrix biosynthesis of intervertebral disc cells. AU - Gonzales, Silvia. AU - Wang, Chong. AU - Levene, Howard. AU - Cheung, Herman S.. AU - Huang, Chun Yuh Charles. N1 - Publisher Copyright: © 2014, Springer-Verlag Berlin Heidelberg.. PY - 2015/2. Y1 - 2015/2. N2 - We have recently found a high accumulation of extracellular adenosine triphosphate (ATP) in the center of healthy porcine intervertebral discs (IVD). Since ATP is a powerful extracellular signaling molecule, extracellular ATP accumulation might regulate biological activities in the IVD. The objective of this study was therefore to investigate the effects of extracellular ATP on the extracellular matrix (ECM) biosynthesis of porcine IVD cells isolated from two distinct anatomical regions: the annulus fibrosus (AF) and nucleus pulposus (NP). ATP treatment significantly promotes ECM deposition and corresponding gene expression (aggrecan and type II collagen) by both cell types in ...
The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. The methods comprise introducing an amount of the polyelectrolyte materials into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material.
Although histopathological grading systems for disc degeneration are frequently used in research, they are not yet integrated into daily care routine pathology of surgical samples. Therefore, data on histopathological changes in surgically excised disc material and their correlation to clinical parameters such as age, gender or body mass index (BMI) is limited to date. The current study was designed to correlate major physico-clinical parameters from a population of orthopaedic spine center patients (gender, age and BMI) with a quantitative histologic degeneration score (HDS). Excised lumbar disc material from 854 patients (529 men/325 women/mean age 56 (15-96) yrs.) was graded based on a previously validated histologic degeneration score (HDS) in a cohort of surgical disc samples that had been obtained for the treatment of either disc herniation or discogenic back pain. Cases with obvious inflammation, tumor formation or congenital disc pathology were excluded. The degree of histological changes was
K.Kato, S.Kitagava. Sapporo Higashi Tokushukai Hospital. Introduction. Surgical interventions on spine concerning hernias of intervertebral disks are one of the most spread interventions in neurosurgery. NLS may become one of the leading methods in diagnostics of intervertebral hernias and evaluation of their treatment effectiveness by surgical methods. Failure rate after herniated disks surgeries with progression of «failed» intervention syndrome is registered not less than in 10-40% cases. Some researchers believe that absence of effect in case of spinal surgery is registered not less than in 25% of cases. NLS-method allows obtaining reliable and visual images of vertebral bodies, spinal canal, intervertebral discs, ligamentous apparatus and soft tissues; it also reveals all changes in surgery area and shows reasons that caused unsuccessful treatment of disc herniation.. The purpose of given study was clarifying lumbar spine condition after operative treatment of intervertebral hernias ...
METHODS: The gene expression profiles data were obtained using the same microarray platform for two groups of patients suffering from degenerative disc diseases: GSE41883 (Human annulus disc cells exposed to TNF-a; 4 samples) and GSE27494 (Human annulus disc cells exposed to IL-1β; 4 samples). The genes that were differentially expressed in these two datasets compared to control disc cells (without cytokine exposure; 4 samples each) were identified using the R language, and were pooled using the Excel software program to select the common differentially expressed genes in the two datasets. The initial functional clustering, signaling pathways and protein-protein interaction relationship analyses were conducted using the DAVID and STRING software programs ...
Objective: This study was designed to assess the prognoses of different lumbar intervertebral disc pathologies on foot drop. Patients and Methods: We retrospectively eval..
Background: Dysregulation of microRNAs (miRNAs) has been reported to be associated with Intervertebral Disc Degeneration (IDD), and accumulating evide..
TY - JOUR. T1 - Multiphasic finite element analysis of physical signals and solute transport in the human intervertebral disc. AU - Yao, Hai. AU - Gu, Wei Yong. PY - 2004/1/1. Y1 - 2004/1/1. UR - http://www.scopus.com/inward/record.url?scp=20444477875&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=20444477875&partnerID=8YFLogxK. U2 - 10.1115/imece2004-59837. DO - 10.1115/imece2004-59837. M3 - Conference article. AN - SCOPUS:20444477875. SP - 393. EP - 394. JO - Advances in Bioengineering, BED. JF - Advances in Bioengineering, BED. SN - 0360-9960. M1 - IMECE2004-59837. T2 - 2004 ASME International Mechanical Engineering Congress and Exposition, IMECE. Y2 - 13 November 2004 through 19 November 2004. ER - ...
Researchers looked specifically at the intervertebral disc, which contains three integrated structures: the inner gelatinous nucleus pulposus (NP), the outer lamellar annulus fibrosus (AF) and the cartilaginous endplates (EP) that connect the invertebral discs to the vertebral bodies. A healthy intervertebral disc is considered immune privileged, and the disc-in particular the AF-acts as a physical and biochemical barrier to inflammation and immune cell infiltration. However, during aging, degeneration and/or injury, mast cells can enter the intervertebral disc. Although scientists have documented the presence of mast cells in painful discs, the role of mast cells in low back pain and intervertebral disc degeneration is still not well understood.. Recent research published online on Oct. 2 in Scientific Reports revealed that mast cells can infiltrate intervertebral disc cells and play a key role in their degeneration.1 The investigators designed their study to better understand the presence and ...
Methods of securing an implant within an intervertebral disc are provided. In some embodiments, systems for minimally invasive disc augmentation include an anulus augmentation component and a nucleus augmentation component. Both are suited for minimally invasive deployment. The nucleus augmentation component restores disc height and/or replaces missing nucleus pulposus. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed. Methods of closing a defect in an anulus fibrosus of an intervertebral disc using a barrier are also provided.
This 3D medical animation depicts the anatomy of the cervical spine and a typical intervertebral disc from C3 through C7. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disc and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
Question - MRI shows intervertebral disc space. How much does this affect lower back pain? . Ask a Doctor about when and why MRI is advised, Ask an Orthopaedic Surgeon
Assessment of the Possibilities of B-Mode Ultrasonography in the Diagnosis of Cervical Intervertebral Discs Hernia in Adolescents
TY - JOUR. T1 - Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load. T2 - A caprine in vitro study. AU - Emanuel, Kaj S.. AU - van der Veen, Albert J.. AU - Rustenburg, Christine M.E.. AU - Smit, Theodoor H.. AU - Kingma, Idsart. PY - 2018/3/21. Y1 - 2018/3/21. N2 - The mechanical behaviour of the intervertebral disc highly depends on the content and transport of interstitial fluid. It is unknown, however, to what extent the time-dependent behaviour can be attributed to osmosis. Here we investigate the effect of both mechanical and osmotic loading on water content, nucleus pressure and disc height. Eight goat intervertebral discs, immersed in physiological saline, were subjected to a compressive force with a pressure needle inserted in the nucleus. The loading protocol was: 10N (6h); 150N (42h); 10N (24h). Half-way the 150N-phase (24h), we eliminated the osmotic gradient by adding 26% poly-ethylene glycol to the surrounding ...
Instrument and method for removing material from an intervertebral disc. The instrument includes outer and inner tubular members. The outer tubular member defines a passage and a cutting window. The inner tubular member is coaxially disposed within the passage, and defines a central lumen and a cutting tip. The cutting tip forms an open mouth having a plurality of teeth. Upon assembly, the cutting tip is exposed within the cutting window combining to define a shaving head. A powered handpiece is coupled to the inner tubular member, and the shaving head is inserted into an intervertebral disc and positioned such that the cutting tip contacts targeted material (e.g., nucleus, annulus and/or end plate). The handpiece is activated to rotate the cutting tip relative to the cutting window. Contacted material is sheared between an edge of the cutting window and the teeth of the cutting tip.
Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.
Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.
1. Dagenais S, Caro J, Haldeman S. A systematic review of low back pain cost of illness studies in the United States and internationally. The spine journal: official journal of the North American Spine Society. 2008;8:8-20 2. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine. 2000;25:487-92 3. Adams MA, Freeman BJ, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine. 2000;25:1625-36 4. Hee HT, Zhang J, Wong HK. An in vitro study of dynamic cyclic compressive stress on human inner annulus fibrosus and nucleus pulposus cells. Spine J. 2010;10:795-801 5. Fernando HN, Czamanski J, Yuan TY, Gu W, Salahadin A, Huang CY. Mechanical loading affects the energy metabolism of intervertebral disc cells. Journal of orthopaedic research: official publication of the Orthopaedic Research Society. 2011;29:1634-41 6. Wang DL, Jiang SD, Dai LY. Biologic response of the ...
Attention!!! Dear Sir or Madam! I would like to inform you of unbelievable efficacy and simplicity of protuberance or herniated pultaceous intervertebral discs repair, which can be monitored by means of magnetic resonance imaging (more). It is important to know that each nerve cell in the nervous system of animal organisms (possibly including plants) has its structural and functional memory, functional in terms of neurophysiology, needed for immanent regulation of bio cybernetic functions, among others to maintain the shape of pultaceous intervertebral discs.. Attention! If objective diagnosis reveals proturbernce or herniated pultaceous intervertebral discs even with compression on the dural sac with pain stenosis. in such case it is advisable to hold skewers between your fingers (choose the sharpest ones), and perpendicularly to the skin perform auto stimulation, triggering stimulus by means of special spatulas which are 7 centimetres wide, beginning with the adams bone, then moving down to ...
The intervertebral disc is one of the most common sources of low back pain. Intervertebral discs are structures in between the lumbar vertebrae that act as shock absorbers for the spine. They help aid trunk motion, transmit loads from one vertebral body to the next, and help protect various structures in the low back such as the lumbar vertebrae and nerve roots. The intervertebral disc is made up of two parts, the annulus fibrosus and the nucleus pulposus. The nucleus pulposus contains a gel made primarily of water and proteoglycans and acts to resist axial compression and distribute compressive forces. The annulus fibrosus is made primarily of collagen fibers and encloses the nucleus pulposus; which helps withstand tension within the disc. There are several theories as to the source of pain generation in a disc injury involving an intervertebral disc that is either degenerative or herniated. Mechanical compression and an inflammatory response is one hypothesis to explain pain from a disc ...
This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
Magnetic Resonance Imaging Follow-up Study on Two Cases of Lumbar intervertebral Disc Sequestration Patients Treated with Oriental Medicine Treatment;kpubs;kpubs.org
Acupuncture for the syndrome of prolapsed lumbar Intervertebral disc --Case studies and clinical experiences By Dr. Yin Hongchun Tel: Main point of diagnosis (1)
The book the lumbar intervertebral disc has not reserved. capable referral can sign from the late. If same, completely the & in its reflective excess.
1970 Dec 12;87(24):737-41. 34. Chang Y, Dennis R, Platt SR, Penderis J. Magnetic resonance imaging of traumatic intervertebral disc extrusion in dogs. Vet Rec. 2007 Jun 9;160(23):795-9. 35. Hansen HJ. A pathologic-anatomical interpretation of disc degeneration in dogs. Acta Orthop Scand. 1951;20(4):280-93. 36. Olsson SE, Hansen HJ. Cervical disc protrusions in the dog. J Am Vet Med Assoc. 1952 Nov;121(908):361-70. 37. Olsson SE. On disc protrusion in dog (enchondrosis intervertebralis); study with special reference to roentgen diagnosis and to the value of disc fenestration. 1) [20]. Contrary to the well-innervated human IVDs [28], the innervation of the canine IVD tissue itself is sparse: nerve endings have only been found in the outer lamellae of the AF and not in the NP, the transitional zone, or the inner AF [29-31]. However, soft tissue structures surrounding the canine IVDs, such as the dorsal longitudinal ligament, are profusely innervated [29, 30]. 06 Gross pathology a N/A a N/A ...
Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleus pulposus cells. The local administration of platelet-rich plasma might stimulate intervertebral disc repair. In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues ...
Background Low back pain (LBP) may be the leading global reason behind disability and it is connected with intervertebral disc degeneration (DD) in a few individuals. and examined by multiplex cytokine assay. Interleukin-8 (IL-8) manifestation was verified by ELISA in CSF and in intervertebral discs. The SPARC-null mouse style of intensifying, age-dependent DD and persistent LBP was useful for pre-clinical validation. Man SPARC-null and control mice received systemic Reparixin, a CXCR1/2 (receptors for IL-8 and murine analogues) inhibitor, for 8?weeks. Behavioral signals of axial radiating and discomfort pain were assessed. Pursuing completion of the study, discs were excised and cultured, and conditioned media was evaluated with a protein array. Findings IL-8 was elevated in CSF of chronic LBP patients with DD compared to pain-free subjects with or without DD. Chronic inhibition with reparixin alleviated AZD-5991 S-enantiomer low back pain behaviors and attenuated disc inflammation in ...
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STUDY DESIGN: The progression of intervertebral disc degeneration (IDD) follows anterolateral stab of adult rabbit lumbar discs by 16-gauge hypodermic needle to a limited (5-mm) depth was studied for up to 24 weeks using magnetic resonance imaging (MRI).OBJECTIVES: To develop a slowly progressive, reproducible rabbit model of IDD suitable for studying pathogenesis and pathopysiology of intervertebral disc degeneration. Moreover, to improve the MRI methods and achieve improved MRIs a custom quad coil tuned and matched for 3.0T was developed. Higher SNR achievable with this coil allowed the acquisition of higher resolution images.METHODS: Part1 - The L2-L3, L3-L4, and L4-L5 lumbar intervertebral discs of 18 skeletally mature female New Zealand White (NZW) rabbits were stabbed by 16-gauge hypodermic needle to a depth of 5-mm in the left anterolateral annulus fibrosis (AF). Serial MRI scans of the stabbed discs and intact L1-2 and L5-6 control discs were performed at 3, 6, 12, and 24 weeks post ...
OBJECTIVE: To study the pathogenesis of the pain of discography and the discogenic low back pain.. METHODS: 19 specimens of lumbar intervertebral discs from 17 patients with discogenic low back pain during posterior lumbar interbody fusion, and 12 physiologically aging discs and 10 normal control discs were collected to investigate the morphologic features and innervation containing neuropeptides substance P (SP), neural filament (NF), and vasoactive-intestinal peptide (VIP).. RESULTS: The distinct morphologic characteristic of the disc from the patient with discogenic low back pain was the formation of the strip zone of vascularized granulation tissue from the nucleus pulposus to the outer part of the annulus fibrosus in which there was one or several fissures. The structure of annulus fibrosus beyond the strip zone of granulation tissue was basically normal. The structures of the aging discs and the control discs showed the age-related changes. The innervation of SP, NF and VIP immunoreactive ...
Fingerprint Dive into the research topics of Potential association of metabolic and musculoskeletal disorders with lumbar intervertebral disc degeneration: Cross-sectional study using medical checkup data. Together they form a unique fingerprint. ...
BACKGROUND CONTEXT Osteoporosis adversely affects disc degeneration cascades, and prophylactic alendronate (ALN) helps delay intervertebral disc degeneration (IDD) in ovariectomized (OVX) rats. However, there remains no information regarding whether ALN affects IDD with bone loss. PURPOSE This study aimed to observe the effects of ALN on degenerative discs with bone loss induced by OVX in rats. STUDY DESIGN This study used controlled in vivo experiments in rodents. METHODS Thirty female Sprague-Dawley rats were randomly assigned to undergo sham surgery (n=10) or OVX surgery (n=20); 3 months later, the OVX animals were injected with either ALN (OVX+ALN, 15 µg/kg/2w, n=10) or normal saline (OVX+vehicle treatment [V], n=10). At 3 months after the ALN intervention, van Gieson staining and immunohistochemistry were used to investigate histologic and metabolic changes in the discs. Bone mineral density (BMD), micro-computed tomography, and biomechanical tests were conducted to determine the biological
Low back pain (LBP) can significantly reduce the quality of life of patients, and has a considerable economic and social impact worldwide. It is commonly associated with disc degeneration, even though many people with degenerate discs are asymptomatic. Degenerate disc disease (DDD), is thus a common term for intervertebral disc (IVD) degeneration associated with LBP. Degeneration is thought to lead to LBP because of nerve ingrowth into the degenerate disc, inflammation, or because degradation of extracellular matrix (ECM) alters spinal biomechanics inappropriately. Thus, while the objectives of some interventions for LBP are to control pain intensity, other interventions aim to deal with the consequences of disc degeneration through stabilizing the disc surgically, by inserting artificial discs or by repairing the disc biologically and preventing progressive IVD degeneration. Despite tremendous research efforts, treatment of LBP through the use of regenerative interventions aiming to repair the IVD is
In this study, we showed that people with an Sp1 polymorphism of the COLIA1 gene had an increased risk of intervertebral disc degeneration. In addition, we examined the association between COLIA1 Sp1 polymorphism and osteoporosis. Although, our results indicate that male carriers of the T allele had higher levels of serum OC, the COLIA1 Sp1 polymorphism did not seem to be related to any other indicator of male osteoporosis. In women, none of the outcome measures of osteoporosis was found to be associated with this studied polymorphism.. Although several recent studies have focused on the association of the COLIA1 Sp1 polymorphism with osteoporosis, until now not much attention has been given to the relation of this genotype with disc degeneration. As far as we know this is the first study to have demonstrated an association between the COLIA1 Sp1 polymorphism and an increased risk of disc degeneration. Although the number of respondents with disc degeneration in this sample is relatively small, ...
Objective: to evaluate plasma vitamin D and cross-linked C-telopeptides of type I (CTx-I) and type II (CTx-II) collagen concentrations in males with lumbar intervertebral disc degeneration (IVD) compared to healthy controls. Improved knowledge might suggest to optimize the vitamin D status of IVD patients and contribute to clarify mechanisms of cartilage degradation. Methods: 79 Italian males with lumbar IVD assessed by Magnetic Resonance Imaging (MRI) and 79 age, sex and BMI-matched healthy controls were enrolled. Plasma 25hydroxyvitamin D (25(OH)D), CTx-I and CTx-II were measured by immunoassays. Circannual seasonality, correlation between biomarkers concentrations and clinical variables were assessed. Results: overall subjects 25(OH)D and CTx-II showed month rhythmicity with acrophase in August/September and October/November, and nadir in February/March and April/May, respectively. An inverse correlation between 25(OH)D and CTx-I, and a direct correlation between CTx-II and CTx-I were ...
Currently, herniated nucleus pulposus (HNP) with radiculopathy and other preconditions are regarded as relative or absolute contraindications for lumbar total disc replacement (TDR). In Switzerland it is left to the surgeons discretion when to operate. The present study is based on the dataset of SWISSspine, a governmentally mandated health technology assessment registry. We hypothesized that preoperative nucleus pulposus status and presence or absence of radiculopathy has an influence on clinical outcomes in patients treated with mono-segmental lumbar TDR. Between March 2005 and April 2009, 416 patients underwent mono-segmental lumbar TDR, which was documented in a prospective observational multicenter mode. The data collection consisted of perioperative and follow-up data (physician based) and clinical outcomes (NASS, EQ-5D). Patients were divided into four groups according to their preoperative status: 1) group degenerative disc disease (DDD): 160 patients without HNP and no radiculopathy, classic
Currently, herniated nucleus pulposus (HNP) with radiculopathy and other preconditions are regarded as relative or absolute contraindications for lumbar total disc replacement (TDR). In Switzerland it is left to the surgeons discretion when to operate. The present study is based on the dataset of SWISSspine, a governmentally mandated health technology assessment registry. We hypothesized that preoperative nucleus pulposus status and presence or absence of radiculopathy has an influence on clinical outcomes in patients treated with mono-segmental lumbar TDR. Between March 2005 and April 2009, 416 patients underwent mono-segmental lumbar TDR, which was documented in a prospective observational multicenter mode. The data collection consisted of perioperative and follow-up data (physician based) and clinical outcomes (NASS, EQ-5D). Patients were divided into four groups according to their preoperative status: 1) group degenerative disc disease (DDD): 160 patients without HNP and no radiculopathy, classic
Introduction: MiR-202-3p is involved in the pathogenesis of intervertebral disc degeneration (IDD) via regulating MMP-1 expression in neuronal precursor cells (NPCs). As an activator of miR-202-3p and KDM6A expression, metformin (MET) may regulate the expression of SOX9 via regulating the...
Intervertebral disc herniation (IVDH) involves displacement of the intervertebral disc secondary to disc degeneration and is extremely common in dachshunds. Clinical signs include pain with or without paresis or paralysis. Mortality rate is high and some cases are left with permanent disability even after treatment. Aims of this study were twofold: Firstly, to investigate whether neutering, i.e. gonadectomy, is associated with increased risk of IVDH in dachshunds, and secondly to investigate whether age of neutering alters risk of IVDH in this breed. Information was obtained for 1964 dachshunds from the owner survey,
Dr Uday Doctor in Pearland, Beaumont and Houston, TX offers lumbar facetectomy or foraminotomy. He treats obstructed neuroforamen, bone spurs and herniated intervertebral disc.
A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.
With degenerative disc disease, the main problem lies within one or more of the intervertebral discs. There is a disc between each of the vertebra in your spine. The intervertebral discs are designed to absorb pressure and keep the spine flexible by acting as cushions during body movement. The discs are similar to shock absorbers. Without the cushion effect of the discs, the vertebrae in your spine would not be able to absorb stresses, or provide the movement needed to bend and twist. Bones cannot sustain high stress repeatedly without being damaged. Much of the mechanical stress of everyday movements is transferred to the discs.. A healthy intervertebral disc has a great deal of water in the nucleus pulposus - the center portion of the disc. The water content gives the nucleus a spongy quality and allows it to absorb spinal stress. Excessive pressure or injuries to the disc can cause the injury to the annulus - the outer ring of tough ligament material that holds the vertebrae together. ...
This study examined the ability of the extreme lateral interbody fusion (XLIF) procedure to restore coronal and sagittal alignments for patients with adult spinal deformity (ASD) using computed tomography multiplanar reconstruction (CT-MPR). Thirty-eight patients with ASD undergoing correction and fixation with XLIF at 114 levels were studied. The coronal segmental Cobb angle, coronal regional Cobb angle (L1-5), sagittal segmental Cobb angle, sagittal regional Cobb angle (L1-5), intervertebral disc height and, vertebral body rotation (VBR) were measured before and after of XLIF surgery using CT-MPR. The mean sagittal segmental Cobb angle, the coronal segmental Cobb angle and VBR were corrected from 5.0° to 9.0°, from 6.3° to 4.3° and from 12.2° to 10.8°, respectively. The mean of the intervertebral disc heights increased significantly from 6.0 mm to 10.4 mm postoperatively. Although increases in coronal segmental Cobb, sagittal segmental Cobb, and intervertebral disc height at each level were
Lumbar total disc replacement surgery in Korea can be a cost saving option for people who are not able to pay for it in their own country. Medical Tourism Co is offering pre-screened quality healthcare facilities for artificial disc replacement surgery in Korea.. Please submit quote request form on right for price estimate.. ...
Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation.
Objective: To determine efficacy of radionucleoplasty infiltration in intervertebral disc herniation Background of Background Data: Radionucleoplasty is a new, minimally invasive procedure for the treatment of disc prolapse. The aim of the present study was to determine associations between the morphology of the basic disease, patient-specific factors and the outcome of the treatment.Disc prolapse is one of the important causes of low back pain radiating to limbs. Apart from conservative therapy all other forms of treatment aim at decompressing the nerve roots. These can be done by taking the disc out by surgery or by decompressing the foramen and disc by different interventions. The various treatment options have confused clinicians due to significant failure rate associated with different kinds of surgeries as well as with different interventions. Injecting a thermal wand fordisc prolapsehas developed as an alternative to chemonucleolysis and disc surgery owing to its high success rates, less ...
Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleuspulposus cells. The local administration of platelet-rich plasma might stimulate intervertebral disc repair. In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (Akeda et al Spine 2006 ...
椎間円板の変性は、背痛および世界的な障害の主要な原因に大きく寄与する。椎間板変性の多くの動物モデルが存在する。一貫した椎間板損傷および再現性のある椎間板変性を達成するドリルビットを利用して、椎間板変性のヒツジモデルを実証する。...
Replacement of Spinal Disc surgery is also popularly known as intervertebral disc athroplasty or total disc replacement. This process involves the spine getting replace with artificial made like metal or plastic ones both in the upper or lower spine. This surgery is done to treat chronic and severe cervical and lumbar pain which results from DDD or Degenerative Disc Disorder.. This procedure is a new one for several types of lumbar pain. Just recently this process is approved by FDA in the United States and research is ongoing worldwide especially in Europe. This might become a standard cure for some lower back pains.. Artificial disc replacement surgery is done to remove and lessen pain while promoting flexibility in the spine. Those who are qualified to have spinal disc replacement surgery are the following;. ...
Science & Technology, Life Sciences & Biomedicine, Biochemical Research Methods, Biochemistry & Molecular Biology, Mesenchymal stem cell (MSC), Regenerative medicine, Tissue engineering, Low back pain (LBP), Intervertebral disc (IVD), IVD degeneration, Biological therapy, Cellular therapy, Articular cartilage, Osteoarthritis (OA), Umbilical cord, Whartons Jelly stem cell (WJSC), Adipose-derived stem cell (AD-MSC), HUMAN UMBILICAL-CORD, LOW-BACK-PAIN, NECROSIS-FACTOR-ALPHA, PLATELET-RICH PLASMA, PULPOSUS-LIKE CELLS, IN-VITRO, NUCLEUS PULPOSUS, PROGENITOR CELLS, STROMAL CELLS, LUMBAR DISC ...
Degeneration of the intervertebral discs is a normal part of aging. However, in some patients, disc degeneration occurs early or more severely than is normal. In some cases, the degeneration of the intervertebral discs can lead to severe, chronic pain.. Degenerative disc disease can manifest as various symptoms. It is a common misconception that only the elderly are affected by DDD. However, this is not the case; DDD can affect younger individuals as a result of injury or other variables. In many patients suffering from degenerative disc disease, the pain is reported as a pins and needles type of sensation. The pain can be exacerbated by daily activities such as sitting down, bending, or reaching. Any dull, aching pain that is localized in the lower back requires the attention of a physician at the soonest available time. In the event that an appointment isnt immediately available, DDD patients often experience relief when they lay down in the prone or supine positions. This position ...
TY - JOUR. T1 - Effect of intradiscal electrothermal treatment with a short heating catheter and fibrin on discogenic low back pain. AU - Derby, Richard. AU - Kim, Byung Jo. PY - 2005/7. Y1 - 2005/7. UR - http://www.scopus.com/inward/record.url?scp=20544467947&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=20544467947&partnerID=8YFLogxK. U2 - 10.1097/01.phm.0000167619.84014.fb. DO - 10.1097/01.phm.0000167619.84014.fb. M3 - Article. C2 - 15973093. AN - SCOPUS:20544467947. VL - 84. SP - 560. EP - 561. JO - American Journal of Physical Medicine and Rehabilitation. JF - American Journal of Physical Medicine and Rehabilitation. SN - 0894-9115. IS - 7. ER - ...
Degenerative disc disease (DDD) describes the natural breakdown of anintervertebral disc of the spine. Despite its name, DDD is not considered a disease, nor is it progressively degenerative. On the contrary, disc degeneration is often the effect of natural daily stresses and minor injuries that cau
An intervertebral disk prosthesis system, which is used for forming an artificial intervertebral disk and comprises a first and a second prosthesis component wherein each of the two prosthesis components comprises a first and a second vertebral body contacting element for placement on neighboring vertebral bodies bounding an intervertebral disk space of a spinal column and a joint element that is mounted between and is moveable relative to at least one of the first and second vertebral body contacting elements, attains a substantially natural range of motion independent of the positioning of the two prosthesis components relative to each other and to the neighboring vertebral bodies. Each prosthesis component has a ball joint formed between the first and second vertebral body contacting elements.
Surgical options to reduce the pain of DDD include:. Discectomy: the surgical removal of herniated disc material that presses on a nerve root or the spinal cord. The procedure involves removing the central portion of an intervertebral disc, the nucleus pulposus, which causes pain by stressing the spinal cord or radiating nerves.. Laminectomy: surgery that creates space by removing the lamina - the back part of the vertebra that covers your spinal canal. Also known as decompression surgery, laminectomy enlarges your spinal canal to relieve pressure on the spinal cord or nerves.. Spinal fusion: a neurosurgical or orthopedic surgical technique that joins two or more vertebrae. This procedure can be performed at any level in the spine (cervical, thoracic, or lumbar) and prevents any movement between the fused vertebrae.. Lumbar Total Disc Replacement: With artificial disc replacement, pain relief is brought about by removal of the painful disc and motion is maintained with the use of a prosthetic ...
Discogenic low back pain remains a difficult lumbar syndrome to treat. Recently developed electro-thermal technology permits precise tissue temperature control, steerability, and controlled lesion production in collagenous tissue. This novel treatment permits targeted shrinkage of annular and nuclear disc collagen (collagen shrinkage has been reported in the literature) and may preserve disc function without tissue necrosis or the need for fusion. It may also be useful in the ablation of pain sensing nociceptors.. ...
Looking for online definition of passive physiologic intervertebral movements in the Medical Dictionary? passive physiologic intervertebral movements explanation free. What is passive physiologic intervertebral movements? Meaning of passive physiologic intervertebral movements medical term. What does passive physiologic intervertebral movements mean?
There are 3 main types of disc injuries. The first disc injury consists of annular fiber tears which do not extend to the outer aspects of the disc. Thus, the inner nuclear material is prevented from completely escaping the disc. The second type of disc injury, commonly referred to as a disc herniation, consists of annular tears which run from the innermost aspects of the annulus (where the nucleus is) to the outermost aspects of the annulus. In this type of injury, the pressurized nuclear material can squeeze through the tears in the annulus and escape to the outside of the disc. When this occurs, the nuclear material may come in contact with nearby spinal nerves and even the spinal cord. In the third type of disc injury, referred to as a disc bulge, the inner nucleus loses hydration; common in those with prolonged spinal stress and the elderly. This results in bulging of the disc much like a tire bulges when it contains inadequate amounts of air. Similar to the previous injury, the nearby ...
While a single-level fusion is in and of itself a major surgery, a multi-level fusion has significantly more potential risks and complications associated with it and should be considered only in rare instances.. While it is a major surgery, fusion surgery can be an effective option for patients to enhance their activity level and overall quality of life. This potential positive outcome is particularly true now that less invasive surgical techniques are available to decrease post-operative discomfort, preserve more of the normal anatomy of the low back, and result in higher rates of fusion than previous techniques.. Lumbar Artificial Disc Replacement Surgery. A newer surgery to treat pain and disability from lumbar degenerative disc disease is artificial disc replacement. The theory is that replacing the disc, instead of fusing the disc space together, maintains more of the normal motion in the lumbar spine, thereby reducing the chance that adjacent levels of the spine will break down due to ...
Degenerative disc disease causes low back pain in two different ways. First, the nerve roots can be pinched as a direct result of degenerative disc disease. A nerve root exits the spinal canal through a small hole called the foramen. The height of the foramen is determined, to a great degree, by the height of the disc. When discs degenerate, they lose height. As a result, when discs degenerate, the foramen loses height. If the space for the nerve root in the foramen gets tight enough the nerve root and become pinched and painful. When this occurs you feel leg pain more than back pain.. Degenerative disc disease can also cause back pain itself. The reason is a little bit complicated. The disc is composed of two parts: a very tough outer part, and an inner gel. Because the inner part of the disc is made out of a gel, it does not have its own blood supply. (Fun fact, the disc is the largest structure in the human body that does not have its own blood supply.) The way your body knows what is part of ...
Is degenerative disc disease work related, even if it results in low back surgery and permanent work restrictions? This second part blog continues the discussion of work-related degenerative disc disease. Yes, if a traumatic work accident caused the degeneration to accelerate beyond normal progression or if the degeneration itself was contributed to by your job duties over time. Your workers compensation attorney must have a sincere understanding of the medicine involving low back degenerative disc disease which can lead to low back disability, permanent work restrictions, and loss of earning capacity.. The nucleus may push through the torn annulus and into the spinal canal. This is called a herniated or ruptured disc. The disc material that squeezes out can press against the spinal nerves. The disc also emits enzymes and chemicals that produce inflammation. The combination of pressure on the nerves and inflammation caused by the chemicals released from the disc cause pain.. As the degeneration ...
Degenerative disc disease is one of the most common causes of low back pain, yet can also be one of the most misunderstood and difficult to diagnose. It is the single most common diagnosis related to serious back pain and neck pain, and tends to occur more frequently with age. As a person ages, the discs can become brittle, susceptible to hemiation, and all together less durable. The main causes of degenerative disc disease are age, family history, lifestyle and age. It is most often reported in patients over 35. Lifestyle is particularly important, individuals who frequently lift heavy items may expose their spine to trauma. Repetitive shock can also promote the development of degenerative discs over time. Degenerative disc disease can be a confusing diagnosis for many patients, and mainly due to the terms Degenerative and Disease, as it is not strictly degenerative or progressive, and it is not really a disease, but rather a condition that produces pain caused by the damaged disc. ...
Interventional Spine announced FDA clearance of its Lateral Opticage Expandable Intervertebral Body Fusion Device. This device joins the Interventional Spine family of Opticage Expandable Interbody Fusion Devices previously cleared for TLIF earlier this year, and used with the Companys PerX360 System.. The Opticage Expandable Intervertebral Body Fusion Device is a lumbar intervertebral body fusion device and is indicated for use with autogenous bone graft in patients with degenerative disc disease (DDD) at one or two contiguous levels from L2-S1. The Opticage Expandable Interbody Fusion Device can be implanted via posterior, transforaminal or lateral approach.. Mr. Walter A. Cuevas, Chief Executive Officer of Interventional Spine said: With this milestone, Interventional Spine continues to lead the spine market in providing the most innovative solutions for surgeons, which in the end, benefit patients. This new indication for the Opticage Expandable Interbody Fusion Devices broadens the ...
Back pain is a common complaint and the origin of this frequently attributed to degenerative disc disease. In the most severe cases, the integrity of the disc and surrounding tissue is lost to such an extent that surgical intervention is necessary. Fusion procedures are commonly used to treat severely degenerated discs. Yet this is known to alter the biomechanics of the operated level, and may create a progression of degenerative decline. Total disc replacement has emerged as a viable treatment but the complexity of the spine is reflected in the clinical results, which trail far behind the success of hip and knee arthroplasty. This may be due to a failure of total disc replacement procedures to restore the natural biomechanics of the spine. The present study has led to the development of a dynamic pre-clinical testing protocol to quantitatively assess the efficacy of disc replacement devices. A six-axis spine simulator was designed and built, and the stiffness matrix testing of porcine lumbar ...
Discectomy refers to the removal of total or a part of an intervertebral disc. Anterior cervical discectomy is a surgical procedure offered at Illinois Spine Institute in Crystal Lake, IL.
The research literature concerning disc degeneration is particularly diverse, and there are no accepted definitions to guide biomedical research, or medicolegal practice.
Deflection images of living outer Annulus cells from Bovine Intervertebral discs, day 6 (after seeding), imaged in culture medium containing 10% fetal bovine serum (FBS) using Contact Mode. Left image was acquired before a series of force curves were taken on the area of the cell that is circled in red. Right image was acquired 45 minutes later. Displayed force curve was acquired on the cell marked with an X. It can be clearly seen that the cells have moved, undergone cytoskeletal reorganization and, where the force curves were taken, were damaged by the AFM tip, 54µm.. Data Courtesy of Y. Dror and J. Klein, Oxford University and Weizmann Institute, NanoInteract consortium.. ...
Our neurosurgical team adopts the finest of spinal surgical practices for patient comfort. There are many artificial disc methods typically classified into two general types: total disc replacement and disc nucleus replacement. In a total disc replacement, all or most of the disc tissue is removed and a replacement device is implanted into the space between the vertebrae. With a disc nucleus replacement, only the center of the disc is removed and replaced with an implant. The outer part of the disc is not removed. By removing disc tissue and eliminating movement, the pain will be significantly reduced.. Complexities of artificial disc replacement ...
Purpose Abnormal stress in the lumbar vertebra, also known as bony stress, can be a precursor to degenerative changes which may manifest as low back pain (LBP). However, the prevalence of bony stress...
Twelve dogs were divided into two equal groups and given lumbar intradiscal injections of 10, 50, or 100 U/ml of chondroitinase ABC reconstituted in sodium acetate buffer. Radiographs of the lumbar spine were made before and after surgery in both groups. Additional films were made at 5 days after su …
Lumbar disc disease (LDD) is among the most common ailments in Western societies.1 In the military, LDD often results in significant impairments and contributes greatly to health care costs and disability.2 Military training often results in exacerbation or presentation of LDD related symptoms. LDD appears to be a multifactorial disorder in which genetics play an important role, as it is evident from several recent studies.3. Collagen is the most abundant structural component of the extracellular matrix. Changes in collagen cross linking have been identified in degenerative disc disease, and LDD was recently associated with a polymorphism of the collagen type IX (COL9A3) gene.3 Type I collagen is the major protein in skin, ligaments, and bone; both COL1A1 and COL1A2 are present in the main components of the intervertebral disc, the annulus fibrosus (primarily) and the nucleus pulposus (secondarily).4. A G→T polymorphism within the COL1A1 regulatory region that affects the recognition site for ...
Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Hypoxia and low pH stressed disc conditioned medium promotes hypersensitivity of peripheral sensory neurons. ORS PSRS 5th Symposium, Skytop PA (US), Nov 3-7, 2019 (poster). Stefanoska D, Ma J, Grad S, Alini M, Peroglio M. Effects of glucose concentration and pH on dorsal root ganglion neurite outgrowth. Pain in EU XI EFIC, Valencia (Spain), Sep 4-7, 2019 (e-poster). Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Effect of pH and oxygen tension on dorsal root ganglion calcium response to bradykinin and neurite sprouting. Pain in EU XI EFIC, Valencia (Spain), Sept 4-7, 2019 (poster). Ma J, Stefanoska D, Hildebrand M, Zeiter S, Alini M, Peroglio M. Validation of cell line models to study intervertebral disc neo-innervation associated with discogenic pain. Swiss 3R Day, Bern (CH), Sept 2, 2019 (poster).. Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Low pH culture of dorsal root ganglion cells as an in vitro model to study pathological changes ...
What is an intradiscal PRP injection and how can it help?. Injection of platelet rich plasma (PRP) is still considered an experimental treatment, although evidence for its effects are mounting. PRP can induce inflammation and healing in the tissue in which it is injected, and has beneficial effects in treating other painful conditions. Recent studies have shown there to be evidence that PRP may be beneficial in patients with degenerative disc disease. With the assumption that inflammation and degeneration are the cause of disc related pain, we inject a small amount of PRP into the nucleus pulposus of the intervertebral disc.. Approximately 40% of low back pain is thought to come from the intervertebral disc disease. As we age, or through trauma and accidents, the discs become damaged. As they become damaged, and through tears in their outer layers, they lose their functional integrity and hydration, leading to the in growth of pain sensing nerves. This is often referred to as discogenic ...
Degenerative disc disease info, Degenerative disc disease or DDD is a spinal condition caused by the breakdown of your intervertebral discs. Symptoms, causes, diagnosis, treatment options.
and cauda equina symptoms is disc height loss. As the disc wears there is loss of disc height and an increased likelihood of the ��� Learn more about the various symptoms and treatment options for Lumbar Degenerative Disc Disease from our spine specialists in NJ and NY. Discs act as natural shock absorbers in the spine, so when they are damaged, it can cause pain. Nonsurgical Treatment for Degenerative Disc Disease. MD. Thanks for the A2A. The discs also may bulge into the spinal canal. These issues can be debilitating and affect people throughout their lives. ... inducing a significant post-operative loss of disc height. Author information: ( Question: Im overweight, and Ive had severe back pain caused by a herniated disc. A disc injury is among the most common types of back ailments. 1. Hypothesis evaluation. Greater volumes of disc removal were associated with accelerated disc height loss. I have had two herniations that required laminectomies and one herniation that did not. 1 thank. ...
Stuttgart: Thieme Wikimedia Commons has media related to Intervertebral discs. Intervertebral Discs Spinal Disc Summary Cross ... An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc ... infection of the intervertebral disc).[medical citation needed] The intervertebral disc functions to separate the vertebrae ... The fibrous intervertebral disc contains the nucleus pulposus and this helps to distribute pressure evenly across the disc. ...
The term intervertebral disc annuloplasty indicates any procedure aimed at repairing the annulus of a bulging intervertebral ... The heat is intended to seal any ruptures in the disc wall and may also burn nerve endings, which can make the area less ... Disc biacuplasty Intradiscal Electrothermal Annuloplasty from The American Academy of Orthopaedic Surgeons v t e (Neurosurgery ... is a recently developed minimally invasive form of annuloplasty consisting of the insertion in the affected disc of a hollow ...
It is a surgical procedure in which degenerated intervertebral discs in the spinal column are replaced with artificial disc ... Multiple artificial discs (or disc replacements) have been approved by the FDA for use in the US, although several have been ... The second disc replacement to achieve wide clinical use was the prodisc total disc replacement; it continues to have worldwide ... Disc replacement is also an alternative intervention for symptomatic disc herniation with associated arm and hand, or leg ...
The documented expansion of disc volume after spaceflight, together with the intervertebral disc injuries after reloading in ... but there is currently no evidence that links the origin of intervertebral disc damage with changes to the disc as a result of ... astronauts may be at an increased risk of intervertebral disc injury or damage when the swollen discs are subjected to ... increasing the susceptibility of these discs to damage. The relative risk of spaceflight-induced intervertebral disc injury ...
"Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications". Acta Veterinaria ... Dachshunds with a number of calcified intervertebral discs at a young age have a higher risk of developing disc disease in ... "Intervertebral Disc Disease". Genetic Welfare Problems of Companion Animals. ufaw.org.uk: Universities Federation for Animal ... Jensen, V. F.; Ersbøll, A. K. (2000). "Mechanical Factors affecting the Occurrence of Intervertebral Disc Calcification in the ...
... though the cells of the disc demonstrate histological changes. Intervertebral disc annuloplasty Kapural, Leonardo; Mekhail, N; ... The procedure is designed to reduce chronic back pain caused by the intervertebral discs. The procedure is in the early stages ... "New radiofrequency technique reduces disc pain with quick recovery time". American College of Radiology. Archived from the ... Petersohn, J; Conquergood, LR; Leung, M (2007-03-09). "Acute histologic effects and thermal distribution profile of disc ...
... more commonly called a slipped disc, is the result of a tear in the outer ring (anulus fibrosus) of the intervertebral disc, ... There are no intervertebral discs. Somites form in the early embryo and some of these develop into sclerotomes. The sclerotomes ... Feeding of the intervertebral discs through the reflex (hyaline ligament) plate that separates the cancellous bone of the ... The upper and lower surfaces of the centrum are flattened and rough in order to give attachment to the intervertebral discs. ...
Braund KG, Ghosh P, Taylor TK, Larsen LH (September 1975). "Morphological studies of the canine intervertebral disc. The ... The vertebral bodies are short and flattened with relatively large intervertebral disk height, and there is congenitally ...
2008). "Aquaporin expression in the human intervertebral disc". J. Mol. Histol. 39 (3): 303-9. doi:10.1007/s10735-008-9166-1. ...
Intervertebral disc arthroplasty: also called Artificial Disc Replacement (ADR), or Total Disc Replacement (TDR), is a type of ... Intervertebral disc annuloplasty (IDET): A procedure wherein the disc is heated to 90 °C for 15 minutes in an effort to seal ... Schol, Jordy; Sakai, Daisuke (April 2019). "Cell therapy for intervertebral disc herniation and degenerative disc disease: ... "Menopause is associated with lumbar disc degeneration: a review of 4230 intervertebral discs". Climacteric. 17 (6): 700-704. ...
Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 24:707-16 Rhodes NP, Bellón JM, Buján MJ, ...
Cushing may have had a ruptured intervertebral disc. He had suffered enough shocks to dislocate half a dozen vertebrae, and ...
... is an intervertebral disc disorder. The facet joints or zygapophyseal joints are synovial cartilage ...
It traverses all of the vertebral bodies and intervertebral discs on their ventral side. It may be partially cut to treat ... The anterior longitudinal ligament runs down the vertebral bodies and intervertebral discs of all of the vertebrae on their ... Intervertebral disc Posterior longitudinal ligament Kayalioglu, Gulgun (2009). "3 - The Vertebral Column and Spinal Meninges". ... is thick and slightly more narrow over the vertebral bodies and thinner but slightly wider over the intervertebral discs. This ...
Kraemer J (March 1995). "Natural course and prognosis of intervertebral disc diseases. International Society for the Study of ... blood pressure Lipid disorders Skin problems such as hair loss Mortality in adults Obesity Osteoporosis Scoliosis Spinal disc ...
Intervertebral disc Minimal invasive spine surgery Osteoporosis Dalton, BE; AC Kohm; LE Miller; JE Block; RD Poser (19 November ...
It may be secondary to intervertebral disk herniation (most commonly at C7 and then the C6 level), degenerative disc disease, ... Heckmann JG, Lang CJ, Zöbelein I, Laumer R, Druschky A, Neundörfer B (October 1999). "Herniated cervical intervertebral discs ... Saal JA, Saal JS (April 1989). "Nonoperative treatment of herniated lumbar intervertebral disc with radiculopathy. An outcome ...
Roberts S, Menage J, Sivan S, Urban JP (February 2008). "Bovine explant model of degeneration of the intervertebral disc". BMC ... Papain has also been used to create a degenerated disc disease model to assess various types of injectable therapies. An ... Chan SC, Bürki A, Bonél HM, Benneker LM, Gantenbein-Ritter B (March 2013). "Papain-induced in vitro disc degeneration model for ...
... and calcification of the intervertebral disc; which gives a susceptibility to IVDD (intervertebral disc disease). GRCh38: ... "FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs". Proceedings of the ... has found that FGF4 retrogene on chromosome 12 is also attributed to the short legs and abnormal intervertebral disc that ... on not only chromosome 18 but also 12 leads to shortened limbs and abnormal vertebrae associated with intervertebral disc ...
Commonly, osteophytes and portions of intervertebral disc are removed. Fusion surgery: Performed when there is evidence of ... Cervical discs or osteophytes indenting the cord anteriorly will therefore be removed by anterior cervical discectomy, whereas ... Thus the chondrocytes which maintain the disc become deprived of nutrition and die. Secondary osteophytes may cause stenosis ... being placed on the vertebrae and the discs between them. The abnormal stress causes the body to form new bone in order to ...
documented limbus vertebrae, intervertebral disc bulges, and disc degeneration. Three of the five practitioners also reported ...
Anterior longitudinal ligament Intervertebral disc Cramer, Gregory D. (2014). "5 - The Cervical Region". Clinical anatomy of ... and widens at the intervertebral disc space. It is generally quite wide and thin. This ligament is composed of smooth, shining ... It also limits spinal disc herniation, although it is much narrower than the anterior longitudinal ligament. The posterior ... It also prevents posterior spinal disc herniation, although problems with the ligament can cause it. The posterior longitudinal ...
"Mechanobiology of the intervertebral disc and relevance to disc degeneration". J Bone Joint Surg Am. 88 (2): 52-57. doi:10.2106 ... Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading, ... "Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen". Arthritis ... "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". ...
Most amphiarthrosis joints are cartilaginous joints (e.g., intervertebral discs). synovial joint (also known as a diarthrosis ... two or more articulation surfaces and an articular disc or meniscus (e.g. knee joint) The joints may be classified anatomically ...
Intervertebral disc Sciatica Spinal disc herniation Arachnoiditis Govind J (2004). "Lumbar radicular pain". Aust Fam Physician ... and foot as often secondary to nerve root irritation from a spinal disc herniation or from osteophytes in the lumbar region of ...
... degenerative disc disease). It is also used as a backup procedure for total disc replacement surgery (intervertebral disc ... Interbody Fusion is a graft where the entire intervertebral disc between vertebrae is removed and a bone graft is placed in the ... Chapter 39: Lower Back Pain and Disorders of Intervertebral Discs. In: Canale, S. T. and J. H. Beaty. Campbell's Operative ... The most common cause of pressure on the spinal cord/nerves is degenerative disc disease. Other common causes include disc ...
p112.(PDF) Virgin, W. J. (1951-11-01). "Experimental investigations into the physical properties of the intervertebral disc". ...
Sun Z, Zhang M, Zhao XH, Liu ZH, Gao Y, Samartzis D, Wang HQ, Luo ZJ (2013). "Immune cascades in human intervertebral disc: the ...
The notochord will form the nucleus pulposus of intervertebral discs. There is some discussion as to whether these cells ...
Mercer S, Bogduk N. The Ligaments and Annulus Fibrosus of Human Adult Cervical Intervertebral Discs. Spine 1999 Apr 1; 24(7): ... 7. Panjabi M, et al., Injury Mechanisms of the Cervical Intervertebral Disc During Stimulated Whiplash. Spine. 29, No 11, 2004 ...
Spinal stenosis at the lumbar region are usually due to disc herniation, hypertrophy of the facet joint and ligamentum flavum, ... Spinal nerves, with the exception of C1 and C2, form inside the intervertebral foramen (IVF). These rootlets form the ... The vertebral bones or intervertebral disks can shatter, causing the spinal cord to be punctured by a sharp fragment of bone. ...
... which allow for movement in for example the vertebral column by compression of the intervertebral discs. Additionally, synovial ...
The pelvic brim stretches from the lumbosacral joint (the intervertebral disc between L5 and S1) to the pubic symphysis and is ...
In veterinary medicine, this is a common procedure to "treat centrally located intervertebral disc herniation". Veterinary ... Through this slot, disc material can be taken out easily until the disc ligament is reached. By removing this ligament the ... Then taking out the medial part of the disc, leaving the lateral part intact and cutting away a small part of the adjacent ... By this way a vertical slot including the upper and lower bone plates next to the disc is created. This makes possible to ...
Adams, AM; Hutton, WC (September 1983). "The effect of posture on the fluid content of lumbar intervertebral discs". Spine. 8 ( ... The flattened lumbar spine may cause back fatigue, disc degeneration and back injuries. But it is not only related to posture, ... Additionally, sitting in a forward flexed posture causes the lumbar spine to flatten that leads to an imbalanced disc pressure ...
In Copenhagen disease, there is a narrowing of the anterior wall of the intervertebral disc with adjacent end plate erosions. ... and some prominent features include pinching of the anterior intervertebral disc, with fusion eventually going towards the rest ... This is followed by fusion, however fusion is usually not seen in the posterior disc space except in later stages of the ... MRI is used to visualize the extent of the intervertebral ankylosis. Radiographs collected soon after birth are used for ...
SCI may occur in intervertebral disc disease, and spinal cord vascular disease. Spontaneous bleeding can occur within or ... Lafuente DJ, Andrew J, Joy A (June 1985). "Sacral sparing with cauda equina compression from central lumbar intervertebral disc ... Cauda equina syndrome may also be caused by central disc prolapse or slipped disc, infections such as epidural abscess, spinal ... however other possible causes include spinal stenosis and impingement on the spinal cord by a tumor or intervertebral disc. ...
"intervertebral disk". Retrieved 2016-06-24. "Magnetic Resonance Imaging (MRI)". Retrieved 2016-06-24. "herniated disc". ... The treatment is an advanced protocol for herniated, bulging and degenerative discs, based on the currently known and accepted ... Method is a registered trademark with the US Patent and Trademark Office for the non-surgical medical treatment of spinal discs ... anatomy of the spinal disc. "TESS -- Error". tmsearch.uspto.gov. Retrieved 2016-06-24. " ...
Commonly used medical phrases involving the neck are cervical collar cervical disc (intervertebral disc) cervical lymph nodes ...
Mixter, WJ; Barr, JS (1934). "Rupture of the Intervertebral Disc with Involvement of the Spinal Canal". N Engl J Med. 211 (5): ... namely lumbar discs. Medical focus on herniated discs was further forwarded by the invention of the MRI in 1977. Over-diagnosis ... work of Mixter and Barr shifted all emphasis in research and treatment from the sacroiliac to the herniated intervertebral disc ... and attention on herniated discs has led to the SI joint becoming an underappreciated pain generator in an estimated 15% to 25 ...
In a 1993 study, J.D. Cassidy, DC, and co-workers concluded that the treatment of lumbar intervertebral disk herniation by side ... Infrequent, but potentially serious side effects, include: vertebrobasilar accidents (VBA), strokes, spinal disc herniation, ...
"The operation to remove a sequestrated lumbar intervertebral disc was successful." Although he was expected to return in the ...
Accounting for cartilagenous intervertebral discs, Diprotodon may have been 20% longer than the reconstructed skeletons, ...
In turn, it is understood that movement lubricates and nourishes the spinal joints and intervertebral discs, keeping skeletal ...
... intervertebral disc disease leads to bulging of the disc or herniation of the disc contents, and the spinal cord is compressed ... These conditions may include malformation of the vertebrae, intervertebral disc protrusion, and disease of the interspinal ... It implants an artificial disc (cervical arthroplasty) in place of the affected disc space. Great Dane Doberman St. Bernard ... Video of a dog with wobbler syndrome treated with the artificial disc replacement (All articles with bare URLs for citations, ...
... in the nucleus pulposis of the adjacent intervertebral disc), reduction of disc height with corresponding loss of the disc ... disc narrowing, desiccation and disc bulging. "A retrolisthesis hyperloads at least one disc and puts shearing forces on the ... these patients had either intervertebral disc bulging or protrusion on CT examination ranging from 3-7 mm into the spinal canal ... The soft tissue of the disc is often caused to bulge in retrolistheses. These cannot be determined by plain films, as the x-ray ...
She noted that the bleeding had been found between Rayney's intervertebral discs, which only occurred in cases of traumatic ...
... such as that caused by intervertebral disc extrusion. In advanced stages, this disorder causes flaccid paraplegia (impairment ...
... is a medical operation used to relieve pressure on nerves that are being compressed by the intervertebral foramina ... disc, scar tissue, or excessive ligament development and results in a pinched nerve. The procedure is often performed as a ...
Effect of Conformation on the Risk of Thoracolumbar Intervertebral Disc Extrusion in Domestic Dogs". PLOS ONE. 8 (7): e69650. ...
... such as in the intervertebral discs or between the carpal bones of the wrist, and the metacarpal bones of the hand. Angular ...
... and intervertebral disc problems. Rather than have Dr. Jho remove the afflicted discs and fuse his vertebrae together, Angle ... herniating two discs, and pulling four muscles. Nonetheless, Angle won the trials and then spent the subsequent five months ... opted for a less conventional surgery where Jho removed only the spurs and selected portions of the discs. The alternative ...
... interthalamic adhesion intertrochanteric line interventricular foramen of Monro interventricular septum intervertebral disc ... areola arm arrectores pilorum arteria dorsalis pedis arterial arcades artery articular condyle of mandible articular disc ... omohyoid omohyoid fascia omohyoid muscle ontogeny operculum ophthalmology ophthalmic artery optic canal optic chiasm optic disc ... inion inner table of skull innervate innominate insula integument integumentary system interatrial septum intercalated disc ...
Because the intervertebral discs which space out the spinal column of the tail have been fossilized, researchers have been able ...
The lumbosacral joint, between the sacrum and the last lumbar vertebra, has, like all vertebral joints, an intervertebral disc ...
Thrombospondins, intervertebral disc proteins, regulate interaction with matrix metalloproteinases (MMPs) 2 and 9, which are ... "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation ...
Right crus arises from L1-L3 vertebral bodies and their intervertebral discs. Smaller left crus arises from L1, L2 vertebral ... bodies and their intervertebral discs. Medial arcuate ligament arises from the fascia thickening from body of L2 vertebrae to ...
... of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently ... Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) ... any part of the spine can have disc degeneration. Depending on the location of the affected disc or discs, intervertebral disc ... medlineplus.gov/genetics/condition/intervertebral-disc-disease/ Intervertebral disc disease. ...
Lumbar (Intervertebral) Disc Disorder Management in the ED * Sections Lumbar (Intervertebral) Disc Disorder Management in the ... encoded search term (Lumbar (Intervertebral) Disc Disorder Management in the ED) and Lumbar (Intervertebral) Disc Disorder ... Lumbar (Intervertebral) Disc Disorder Management in the ED Differential Diagnoses. Updated: Aug 13, 2021 ... Disc height discrepancy between supine and standing positions as a screening metric for discogenic back pain in patients with ...
Cartilagenous End Plate of Intervertebral Disc. Cartilagenous End Plate of Intervertebral Disc. - Discussion:. - cartilage end ... intervertebral disc in the adult is avascular;. - cells w/in it are sustained by diffusion of nutrients into disc thru porous ... this lack of interconnection between end plate and the vertebrae may render disc biomechanically weak against horizontal shear ...
Learn about the latest solutions to overcome common challenges of testing intervertebral discs. ... Intervertebral disc replacement is a surgical technique for the treatment of lower back pain related to degenerative disc ... Disc prostheses are designed to be load bearing over the physiological range of disc motion, and to give years of pain-free and ... ASTM F2346 provides a methodology for characterizing the static strength and dynamic fatigue behavior of disc prostheses. The ...
... to compare the facet asymmetry of lumbar disc herniation and the degeneration of cartilage endplate and intervertebral disc of ... Results: There was no significant correlation between L4/5 facet asymmetry and L5/S1 intervertebral disc degeneration score and ... between the facet joint angle of lumbar disc herniation and the degeneration of upper proximal segment intervertebral disc. ... Methods: Fifty patients with L4/5 lumbar disc herniation were enrolled in the study. All patients underwent lumbar MRI ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Distraction results in disc rehydration, stimulated extracellular matrix gene expression, and increased numbers of protein- ... Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein ... Summary of background data: Disc degeneration can result from hyper-physiologic loading. Distracted discs with degeneration ... Distracted discs showed more BMP-2 (19.67 vs. 3.67 in 56 days compression) and collagen 2 (18.67 vs. 11.33 in 56 days ...
Evidence of intervertebral mechanical markers in chronic, non-specific low back pain (CNSLBP) is lacking. This research used ... Uneven intervertebral motion sharing is related to disc degeneration and is greater in patients with chronic, non-specific low ... Uneven intervertebral motion sharing is related to disc degeneration and is greater in patients with chronic, non-specific low ... It is also considered to be related to intervertebral disc degeneration [11]. However, no reliable diagnostic tool that could ...
Effects of Design Factors and Microenvironment on Mesenchymal Stem Cells and Nucleus Pulposus Cells for Intervertebral Disc ...
Systems. Intervertebral disc disease is a degenerative process of the intervertebral disc that causes loss of normal disc ... Intervertebral Disc Disease at a Glance. Loretta J. Bubenik, DVM, MS, Diplomate ACVS. Neurology. ,December 2006,Peer Reviewed ... 9. Intervertebral disc disease. Simpson ST. Vet Clin North Am Small Anim Pract 22:889-897, 1992.. 10. The variation of the ... 5. Intervertebral disc disease. Hoerlein BF. In Oliver JE, Hoerlein BF, Mayhew IG (eds): Veterinary Neurology-Philadelphia: WB ...
While it is well-known that mechanical signals can either promote or disrupt intervertebral disc (IVD) homeostasis, the ... of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc. ... of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc ... of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc ...
Intervertebral disc degeneration (LDD) is reported to account for 50% of LBP in young adults, but the interplay of factors such ... Different types of intervertebral disc network models will be used and combined to successively incorporate cell culture ... 2 PhD positions to advance integrated computational simulations of intervertebral disc degeneration. Posted on December 22, ... Description: The successful candidate will work on the multiscale modelling of the mechanisms of intervertebral disc regulation ...
Intervertebral disc disease is a usual neurological disorder in dogs, which the spinal cord is compressed by intervertebral ... Fibrocartilaginous Embolism Associated with the Extrusion of the Intervertebral Disc in a Dog Authors. * Rafael Oliveira Chaves ... The intervertebral disc extrusion occurs predominantly in dogs with age between three and six years old, in the cervical, ... During the necropsy was observed intervertebral disc extrusion between L1-L2 vertebrae in a dog and between C3-C4 vertebrae in ...
Keywords: SDF-1, CXCR4, intervertebral disc, nucleus pulposus, endplate Citation styles. APA Copy. Zhang, H., Zhang, L., Chen, ... Stromal Cell-derived Factor-1 and its Receptor CXCR4 are Upregulated Expression in Degenerated Intervertebral Discs. Int J Med ... Stromal Cell-derived Factor-1 and its Receptor CXCR4 are Upregulated Expression in Degenerated Intervertebral Discs Hua Zhang1 ... We investigated the expression of SDF-1 and CXCR4 in intervertebral discs (IVDs). ...
The remaining lumbar discs were used as normal controls. Three months after cABC injection, the L3-4 discs of all animals were ... the authors conclude that the injection of MPCs into degenerate intervertebral discs can contribute to the regeneration of a ... to restore the extracellular matrix of degenerate discs in an ovine model. Methods Three adjacent lumbar discs of 24 adult male ... The adjacent L4-5 degenerate discs remained untreated; the L5-6 discs were injected with HA only. The animals were euthanized ...
Purpose: The intervertebral disc is dependent on the extracellular matrix for its function, which is produced and maintained by ... abstract = "Purpose: The intervertebral disc is dependent on the extracellular matrix for its function, which is produced and ... N2 - Purpose: The intervertebral disc is dependent on the extracellular matrix for its function, which is produced and ... AB - Purpose: The intervertebral disc is dependent on the extracellular matrix for its function, which is produced and ...
The purpose of this study was to identify a specific circular RNA and to investigate its regulatory mechanism in intervertebral ... disc degeneration (IDD). CircGLCE was selected after microarray analyses and was further analysed by RT-qPCR and FISH. CircGLCE ... 7. Loreto C, Musumeci G, Castorina A, Loreto C, Martinez G. Degenerative disc disease of herniated intervertebral discs is ... 37. Wang WJ, Yu XH, Wang C, Yang W, He WS, Zhang SJ, Yan YG, Zhang J. MMPs and ADAMTSs in intervertebral disc degeneration. ...
Tan C, Kent GN, Randall AG, Edmondston SJ, Singer K. Collagen and elastin crosslinks in human intervertebral discs and ... Tan, C, Kent, GN, Randall, AG, Edmondston, SJ & Singer, K 2002, Collagen and elastin crosslinks in human intervertebral discs ... Collagen and elastin crosslinks in human intervertebral discs and ligamentum flavum: age, gender and spinal level influences. ... Collagen and elastin crosslinks in human intervertebral discs and ligamentum flavum: age, gender and spinal level influences. ...
Pro-Inflammatory and Neurotrophic Factor Responses of Cells Derived from Degenerative Human Intervertebral Discs to the ... Pro-Inflammatory and Neurotrophic Factor Responses of Cells Derived from Degenerative Human Intervertebral Discs to the ... Cutibacterium acnes; disc cells; co-culture; inflammation; neurotrophic factors; gene expression; intracellular ... acnes in the underlying aetiology of disc degeneration. To investigate this, we examined the upregulation of IL-1 beta, and ...
Modelled according to nature, in SOMSO-PLAST®. After Dr. Lie. Presentation of normal anatomy in conjunction with pathological changes: I. Normal anat…
SUMMARY OF BACKGROUND DATA: The intervertebral disc is the largest avascular tissue in the body. Nutrients necessary for ... In contrast, the concentration of lactate, produced by the cells, was highest in the center and fell towards the disc-blood ... RESULTS: The model predicted that concentrations of oxygen and glucose, which are consumed by cells, fell towards the disc ... Concentration levels decreased with a decrease in fractional exchange area and diffusivity, or with an increase in disc height ...
Since intervertebral disc protrusions occur more commonly in chondrodystrophoid breeds of dog, the effect of collagenase should ... Two of these dogs had six intervertebral discs (T10/11 to L2/3) injected with 500 units of collagnease VIIs delivered ... An investigation into the effectiveness of collagenase for the percutaneous discolysis of thoracolumbar intervertebral discs in ... was based on the amount of nuclear material removed from the disc and the associated modifications to intervertebral disc ...
Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? ... Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? ...
Major non-surgical treatments (Up to 90% of the intervertebral disc problems can be treated without surgery!) ... When the discs cause problems. As a well-informed patient, you not only assist the treatment of your symptoms by your doctor, ... This book helps you to recognize disc problems and to understand the necessary treatment steps and their effectiveness. ...
Herniated or ruptured disc; Degenerative disc disease; Thinning disc; Bulging disc What is intervertebral disc disease? ... In intervertebral disc disease (IVDD) the A prolapsed (herniated) disc occurs when the outer fibres of the intervertebral disc ... The intervertebral discs serve as the spines shock Intervertebral Disc Disease (IVDD) is a common occurrence in ... An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc ...
Injectable disc-derived ecm hydrogel functionalised with chondroitin sulfate for intervertebral disc regeneration. Acta ... A biomimetic artificial disc with improved mechanical properties compared to biological intervertebral discs. Adv Funct Mater. ... Home Nanotechnology Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration ... Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury. Sci Adv. ...
It seems we cant find what youre looking for. Perhaps searching can help.. ...
It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain. ... Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. ...
Intervertebral Disc Disease. *Low Back Pain. *Memory Evaluation. *Migraine. *Multiple Sclerosis (MS) ...
intervertebral disc disease. Describe in detail possible signs and symptoms in a patient that has intervertebral disc disease ... Compared and contrasted the signs and symptoms of intervertebral disc disease and musculoskeletal disorder with reference to ... Discussed the difference in treatment modalities between intervertebral disc disease and musculoskeletal disorder.. Patient 3. ...
  • Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. (medlineplus.gov)
  • region of the spine are most often affected in intervertebral disc disease, any part of the spine can have disc degeneration. (medlineplus.gov)
  • Specific variations in several collagen genes seem to affect the risk of developing intervertebral disc disease by impairing the ability of collagens to interact with each other, decreasing the stability of the disc and leading to its degeneration. (medlineplus.gov)
  • It is thought that these gene variants can lead to an immune response that results in inflammation and water loss (dehydration) of the discs, which causes their degeneration. (medlineplus.gov)
  • The associated variants can lead to disc degeneration and herniation. (medlineplus.gov)
  • The advantage of this technique over traditional spinal fusion is that it preserves or restores motion in the spine, and has the potential to delay the onset of degeneration of healthy discs at adjacent levels in the spine. (instron.com)
  • To analyze the relationship between facet joint asymmetry and adjacent intervertebral disc degeneration in lumbar disc herniation. (scirp.org)
  • All patients underwent lumbar MRI examination, to compare the facet asymmetry of lumbar disc herniation and the degeneration of cartilage endplate and intervertebral disc of adjacent segments, and analyze the relationship between them. (scirp.org)
  • There was a positive correlation between the facet joint angle of lumbar disc herniation and the degeneration of upper proximal segment intervertebral disc. (scirp.org)
  • Lumbar disc herniation is a common clinical disease with intervertebral disc degeneration as the main pathological change. (scirp.org)
  • Facet joint asymmetry and adjacent disc degeneration play an important role in the pathophysiology of intervertebral disc herniation. (scirp.org)
  • The cartilage endplate and intervertebral disc degeneration of L3/4 and L5/ S1 discs were compared. (scirp.org)
  • 2) Pfirmann grading [6] was used as the standard of intervertebral disc degeneration, which was divided into A-E grades. (scirp.org)
  • An animal model of degeneration was used to determine the effects of disc distraction, and was evaluated with magnetic resonance imaging (MRI) as well as gene and protein expression levels. (nih.gov)
  • Disc degeneration can result from hyper-physiologic loading. (nih.gov)
  • Distracted discs with degeneration showed histologic signs of tissue recovery. (nih.gov)
  • Passive recumbent and active standing protocols were used and the relationships of these variables to age and disc degeneration were assessed. (springer.com)
  • Composite disc degeneration (CDD) scores comprising the sum of Kellgren and Lawrence grades from L2-S1 were obtained. (springer.com)
  • The relationship between disc degeneration and MSI was augmented in patients, but not in controls during passive motion and similarly for MSV during active motion, suggesting links between in vivo disc mechanics and pain generation. (springer.com)
  • Disc degeneration is the main cause of the disease, but traumatic disc herniation also occurs. (cliniciansbrief.com)
  • In chondrodystrophic breeds, the disc undergoes degeneration over time (chondroid metaplasia), but many changes are present early in life.2 Such changes are characterized by loss of water and proteoglycans and alterations in glycosaminoglycan content, resulting in a harder, more cartilaginous nucleous pulposus and a weakened annular ligament.10 As degeneration progresses, normal function is lost and sudden extrusion of disc matter can occur (Hansen type I lesions). (cliniciansbrief.com)
  • In nonchondrodystrophic breeds, degeneration usually occurs later in life and involves fibrous metaplasia of the disc instead of the cartilaginous changes noted for chondrodystrophic breeds.2 Nonchondrodystrophic disc disease is usually characterized by disc bulging (Hansen type II lesions) rather than extrusion. (cliniciansbrief.com)
  • Intervertebral disc degeneration (LDD) is reported to account for 50% of LBP in young adults, but the interplay of factors such as genetics, environmental, cellular responses, social and psychological is poorly understood. (esbiomech.org)
  • Chondroid or fibroid degeneration of the intervertebral disc is the most common cause of spinal cord compression in small animals. (ufrgs.br)
  • SDF-1 and CXCR4 were both expressed in IVDs, and the levels of SDF-1 and CXCR4 were both significantly higher in the degeneration group than in the normal group of human (or rat) discs. (medsci.org)
  • Chronic low-back pain of discal origin is linked strongly to disc degeneration. (thejns.org)
  • Three adjacent lumbar discs of 24 adult male sheep were injected intradiscally with chondroitinase-ABC (cABC) to initiate disc degeneration. (thejns.org)
  • Injection of cABC decreased the disc height index (DHI) of target discs by 45%-50%, confirming degeneration. (thejns.org)
  • However, disc degeneration is common and may present early on in life, being associated with major clinical problems such as herniation and back pain. (aston.ac.uk)
  • The purpose of this study was to identify a specific circular RNA and to investigate its regulatory mechanism in intervertebral disc degeneration (IDD). (aging-us.com)
  • The major underlying physiological process involved in lower back pain is intervertebral disc degeneration (IDD), which leads to progressive structural abnormality of the lumbar spine and accelerated ageing of the intervertebral discs [ 3 , 4 ]. (aging-us.com)
  • Previously, we proposed the hypothesis that similarities in the inflammatory response observed in acne vulgaris and degenerative disc disease (DDD), especially the central role of interleukin (IL)-1 beta, may be further evidence of the role of the anaerobic bacterium Cutibacterium (previously Propionibacterium) acnes in the underlying aetiology of disc degeneration. (muni.cz)
  • The intervertebral discs serve as the spine's shock Intervertebral Disc Disease (IVDD) is a common occurrence in chondrodystrophoid dogs like Dachshunds, Beagles, Cocker Spaniels, Pekingese, etc (aka dogs Excessive reactive oxygen species (ROS) generation in degenerative intervertebral disc (IVD) indicates the contribution of oxidative stress to IVD degeneration Oct 21, 2019 Degenerative disc disease is a condition in which the intervertebral discs of the spine become weak and start to deteriorate. (web.app)
  • Sammanfattning : Sciatica due to lumbar disc herniation has for many decades nucleus pulposus (NP) from the intervertebral disc might cause functional and as well as possible accelerated degeneration of adjacent segment discs (ASD) The idea of transforming a spinal disc into connective tissue in order to cure low back pain (clBP), i.e. (web.app)
  • Dou Y, Sun X, Ma X, Zhao X, Yang Q. Intervertebral disk degeneration: the microenvironment and tissue engineering strategies. (channel969.com)
  • Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs. (channel969.com)
  • Transplantation of mesenchymal stem cells embedded in atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration. (channel969.com)
  • Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell. (channel969.com)
  • Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. (channel969.com)
  • ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. (channel969.com)
  • [ 12 ] determined that the etiology of Z-joint degeneration was secondary to intervertebral disc degeneration . (medscape.com)
  • Appointed as Wellcome Trust fellow in Twin Research in 2007, Frances has been researching genomics and 'omics of chronic pain including low back pain, intervertebral disc degeneration and chronic widespread pain, for two decades. (kcl.ac.uk)
  • Frances remains clinically active as a consultant rheumatologist at Guy's and St Thomas' NHS FT. She is involved in the care of patients with arthritis and spine disorders, in particular osteoporosis and intervertebral disc degeneration. (kcl.ac.uk)
  • elbow dysplasia, Legg-Calvé-Perthes disease (degeneration of the femoral head which can cause lameness and joint swelling), intervertebral disc disease (pressure on the spinal cord that can cause paralysis), progressive retinal atrophy (PRA: degeneration of retina which can lead to blindness), epilepsy and blindness. (omlet.us)
  • Intervertebral Disc Aging, Degeneration, and Associated Potential Molecular Mechanisms. (juniperpublishers.com)
  • Disc degeneration involves the loss of water and disc hydration. (drjoannagarvey.com)
  • Chiropractic manages disc problems like disc degeneration with a variety of forms of care. (drjoannagarvey.com)
  • Listen to this PODCAST with Dr. James Cox on The Back Doctors Podcast with Dr. Michael Johnson as he further describes the process of disc degeneration and how Cox® Technic Flexion Distraction helps in its care via manipulation. (drjoannagarvey.com)
  • Disc degeneration is a loss of water. (drjoannagarvey.com)
  • The raised funds will be used to advance GeneQuine's lead candidate GQ-303 for osteoarthritis (OA) to a phase 1 clinical trial, to develop new gene therapies for the treatment of intervertebral disc degeneration, to expand GeneQuine's gene therapy vector platform and to grow the company's operations. (lifesciencenord.de)
  • GeneQuine is also developing HDAd-based gene therapies for treatment of intervertebral disc degeneration. (lifesciencenord.de)
  • Despite the tremendous unmet medical need in the treatment of intervertebral disc degeneration as one of the main causes for chronic low back pain, no disease-modifying medications are currently available. (lifesciencenord.de)
  • We are very excited that we have raised this financing round, and are eager to put these funds to work to bring GQ-303 to the clinic, accelerate the development of gene therapy for intervertebral disc degeneration and build out our HDAd vector platform. (lifesciencenord.de)
  • Human disc degeneration is associated with increased MMP 7 expression. (shu.ac.uk)
  • During intervertebral disc (IVD) degeneration, normal matrix synthesis decreases and degradation of disc matrix increases. (shu.ac.uk)
  • A number of proteases that are increased during disc degeneration are thought to be involved in its pathogenesis. (shu.ac.uk)
  • We investigated the localization of MMP 7 in human, histologically graded, nondegenerate, degenerated and prolapsed discs to ascertain whether MMP 7 is up-regulated during disc degeneration. (shu.ac.uk)
  • A significant increase in the proportion of MMP 7 immunopositive cells was seen in the nucleus pulposus of discs classified as showing intermediate levels of degeneration and a further increase was seen in discs with severe degeneration. (shu.ac.uk)
  • Prolapsed discs showed more MMP 7 immunopositive cells compared to nondegenerated discs, but fewer than those seen in cases of severe degeneration. (shu.ac.uk)
  • Disc degeneration tends to happen faster than most other aging processes, which is why it is often found in young adults. (perfectbalanceclinic.com)
  • X rays can also pinpoint other signs of degeneration including narrowing of disc space and sclerosis. (perfectbalanceclinic.com)
  • Disc degeneration and the abnormal overgrowth of bone spurs are mainly to blame for cervical osteoarthritis. (uppercervicalawareness.com)
  • Similar to cervical osteoarthritis, disc degeneration disease also affects aging people. (uppercervicalawareness.com)
  • Most of the available evidence is related to osteoarthritis, hypertension, and intervertebral disc displacement outcomes. (bvsalud.org)
  • Positive effects (26 reviews) were mainly related to osteoarthritis (4 revisions), obstetric labor (4), intervertebral disc displacement (2) and dyspepsia (2). (bvsalud.org)
  • This article reports a case of disc displacement and closed lock in a patient who reported limited mouth opening and pain as the main symptoms. (bvsalud.org)
  • The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine. (medlineplus.gov)
  • The inclusion criteria were "guidelines for diagnosis and treatment of lumbar disc herniation" formulated by the spine surgery group of orthopedics, Chinese Medical Association in 2020, excluding patients with lower extremity arthritis and lumbar tumor, as well as lumbar scoliosis, lumbar spondylolisthesis, lumbar compression fractures and other spinal deformities. (scirp.org)
  • For the assessment of mechanical destabilisation of the spine caused by injury, the intervertebral neutral zone is thought to be the most sensitive measure [ 6 ]. (springer.com)
  • Intervertebral discs function as shock absorbers and stabilizers of the spine. (cliniciansbrief.com)
  • Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold the vertebrae together, and to function as a shock absorber for the spine. (web.app)
  • Välj mellan 232 premium Spine Disc av högsta kvalitet. (web.app)
  • Academics and clinicians often assume that the anatomy of the cervical intervertebral disc is similar, if not identical, to that of the lumbar spine. (bradychiropracticgroupblog.com)
  • It helps in giving relief in the pain of prolapsed disc by strengthening the muscle that supports your spine. (physiogain.com)
  • IVDD is a degenerative condition of the spine where the discs in your dog's back age faster than they should normally. (dogwheelchairlife.com)
  • That's where you learn that your dog's had an injury to the spine called a ruptured, herniated or slipped disc, due to IVDD. (dogwheelchairlife.com)
  • According to Veterinary Partner™ the most common areas for IVDD disc problems are in the middle of the spine at T11-T12 or at L2 - L3 in the lower back. (dogwheelchairlife.com)
  • And instead of their discs drying out, Type II dogs have discs that soften until they're unable to cushion the spine. (dogwheelchairlife.com)
  • The most common surgical procedure used to manage IV disc herniation is either a ventral cervical slot for C2-T1 disc herniation or hemilaminectomy in the thoracolumbar spine. (dvsc.com)
  • This exhibit illustrates sagittal conditions of the cervical and lumbar spine with multiple intervertebral disc injuries. (anatomicaljustice.com)
  • Disc herniations are depicted from C2-7 in the cervical spine, and T1-3 in the upper thoracic spine. (anatomicaljustice.com)
  • This 3D medical animation depicts the anatomy of the cervical spine and a typical intervertebral disc from C3 through C7. (smartimagebase.com)
  • Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. (smartimagebase.com)
  • His areas of clinical expertise include spine deformities and scoliosis, degenerative spine disorders, spine tumors and disc arthroplasty. (hopkinsmedicine.org)
  • The forces that are normally supported by the disc are transferred to the ligaments and joints around the spine. (centracare.com)
  • Unlike other lumbar spine pathologies such as disc herniation, Z-joint-mediated pain likely will not worsen with an increase in intra-abdominal and thoracic pressure. (medscape.com)
  • The cross section of the lumber spine is assumed to be uniform, and the material properties are different for the vertebral bodies, endplates, and intervertebral discs. (springeropen.com)
  • To derive equations with biomedical approach, they were developed with n segments of the lumbar spine including vertebrae, intervertebral discs, and endplates. (springeropen.com)
  • If the cross section of the lumber spine is assumed to be almost uniform while the material properties are different for the vertebral bodies, endplates, and intervertebral discs, it can be considered as a beam-like structure whose natural frequencies can be evaluated using prescribed methods. (springeropen.com)
  • Intervertebral disc disease (IVDD) affects the discs between the vertebrae in the spine. (updatedideas.com)
  • Chiropractic Spine Sports And Rehabilitation implements spinal manipulation to take care of our spine pain patients experiencing Tonawanda back pain and neck pain and related leg and arm pain and recommends exercise to support the effects of spinal manipulation to take care of the spinal disc. (drjoannagarvey.com)
  • (4) Chiropractic Spine Sports And Rehabilitation utlilizes the gentle distraction treatment called Cox Technic spinal manipulation to make a push-pull-pumping effect on the disc and its endplates to encourage the disc to imbibe fluid into the disc help our Tonawanda spine pain patients. (drjoannagarvey.com)
  • Chiropractic Spine Sports And Rehabilitation guides Tonawanda chiropractic back pain sufferers toward healthier discs with spinal manipulation and exercise to coost water content. (drjoannagarvey.com)
  • There are 33 vertebrae in your spine and 23 intervertebral discs which are located between each of the cervical, thoracic and lumbar vertebrae. (thespinepro.com)
  • These flat, thin discs serve as shock absorbers for your spine. (thespinepro.com)
  • If the herniated disc is located in the upper spine (cervical), you may experience radiating pain in your fingers, arms and shoulders. (thespinepro.com)
  • If the disc herniation is in the lower spine (lumbar) patients may experience tingling pain in their feet, legs, hips and buttocks. (thespinepro.com)
  • A herniated disc can occur in any intervertebral disc on your spine, but most commonly they are found in your lower (lumbar) spine. (thespinepro.com)
  • The symptoms of a herniated disc depend on their location along the spine. (thespinepro.com)
  • If you feel twinges of pain in your neck or between your shoulder blades, tingling sensations or even numbness along your arms to your fingers, you may have herniated disc in your upper spine. (thespinepro.com)
  • Laser disc surgery is a type of procedure that is used to treat problems with the intervertebral discs in the spine. (londonspine.com)
  • These discs are located between the vertebrae and provide cushioning and support for the spine. (londonspine.com)
  • Laser disc surgery may be used to remove or repair damaged discs or to relieve pressure on the nerves in the spine. (londonspine.com)
  • Laser spine surgery is a type of procedure that is used to treat conditions that affect the spine, such as herniated discs, spinal stenosis, and degenerative disc disease. (londonspine.com)
  • Back braces also take support away from the vital areas of your back, such as the spine, intervertebral discs, and vertebrae. (arabianhomecare.com)
  • This procedure involves making an incision on the front side of the neck (anterior cervical spine), followed by the removal of disc material and/or a portion of the bone around the nerve roots and/or spinal cord to relieve the compression and provide them with additional space. (socalbrainandspine.com)
  • Fifty patients with L4/5 lumbar disc herniation were enrolled in the study. (scirp.org)
  • Some patients with lumbar disc herniation may have degenerative changes in adjacent segments. (scirp.org)
  • L4/5 segment is the most common site of lumbar disc herniation. (scirp.org)
  • In this study, MRI was used to observe the imaging features of L4/5 lumbar disc herniation and the adjacent intervertebral discs of L3/4 and L5/S1. (scirp.org)
  • 50 patients with L4/5 disc herniation in the seventh Affiliated Hospital of Sun Yat sen University were selected from May 2018 to September 2020, including 33 males and 17 females. (scirp.org)
  • Intervertebral disc disease is a degenerative process of the intervertebral disc that causes loss of normal disc architecture and function, resulting in disc bulging or herniation into the spinal canal. (cliniciansbrief.com)
  • Nonspecific clinical signs of disc herniation include exercise intolerance, diminished appetite, vocalization, and gait alteration. (cliniciansbrief.com)
  • Background: To investigate the effect of oxygen-ozone (O 2 -O 3 ) injection on thoracolumbar intervertebral disc herniation (IVDH) in dogs. (iiarjournals.org)
  • The object was to determine whether the percutaneous injection of collagenase enzyme could be an alternative to fenestration as a prophylaxis against herniation of a degenerate intervertebral disc. (massey.ac.nz)
  • The investigators concluded that collagenase appeared to be an attractive alternative to fenestration for the prophylaxis of intervertebral disc herniation, on the basis of its completeness of removal of nuclear tissue, and its simplicity, cheapness, non-invasiveness and the lack of medium and short term complications. (massey.ac.nz)
  • It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. (web.app)
  • A type I (Hansen's) intervertebral disk abnormality Intervertebral disk: type 1 herniation is seen in This occurs most frequently in the lower lumbar region. (web.app)
  • As such, herniation of the intervertebral discs is much more common in youth and less common as people age. (bradychiropracticgroupblog.com)
  • An L2-3 sequestered disc herniation means a piece of the internal jelly of the disc (the nucleus) has extruded from the complete through and through tear of the disc wall and is separated from the disc laying as a free fragment in the spinal canal. (neckandback.com)
  • This condition is called a recurrent disc herniation and the odds of it happening are about 10% in the active population. (neckandback.com)
  • Without a doubt, the most common neurosurgical condition presented to veterinarians is IV disc herniation.Herniated discs occur between C2 - C7 and T10 - L5, with C2 - C3 and T12 - T13 being the most common. (dvsc.com)
  • However, IV disc herniation can occur in almost any breed-even in cats. (dvsc.com)
  • Diseases such as fibrocartilaginous emboli (FCE), meningitis, and neoplasia can mimic the symptoms of disc herniation and must be ruled out during the diagnostic work-up. (dvsc.com)
  • Unfortunately, if the time interval between episodes is more than a few months, an acute disc herniation with a very favorable surgical outcome can become a chronic herniation with a more guarded outcome. (dvsc.com)
  • Attempts to remove a chronic disc herniation is more challenging, has a higher potential to worsen neurological symptoms and can result in permanent deficits. (dvsc.com)
  • Diagnostic spinal imaging techniques used to diagnose disc herniation include myelogram, CT scan or MRI. (dvsc.com)
  • However, plain radiographs cannot be relied upon to diagnose an intervertebral disc herniation or to plan surgical intervention. (dvsc.com)
  • Patients suffering from chronic disc herniation can generally be returned to an ambulatory status, but often some degree of incoordination and occasional weakness may be present for the remainder of the pet's life. (dvsc.com)
  • Transforaminal epidural steroid injections prevent the need for surgery in patients with sciatica secondary to lumbar disc herniation: a retrospective case series. (unifesp.br)
  • Epidural steroid injection for lumbar disc herniation in NFL athletes. (unifesp.br)
  • Buttermann GR. Treatment of lumbar disc herniation: epidural steroid injection compared with discectomy. (unifesp.br)
  • The impact of epidural steroid injections on the outcomes of patients treated for lumbar disc herniation. (unifesp.br)
  • Plasma disc decompression compared with fluoroscopy-guided transforaminal epidural steroid injections for symptomatic contained lumbar disc herniation: a prospective, randomized, controlled trial. (unifesp.br)
  • A significant number of individuals suffer from low back pain throughout their lifetime, and the medical costs related to low back pain and disc herniation are gradually increasing in Korea. (bvsalud.org)
  • Korean medicine interventions have been used for the treatment of lumbar intervertebral disc herniation. (bvsalud.org)
  • Therefore, we aimed to update the existing Korean medicine clinical practice guidelines for lumbar intervertebral disc herniation. (bvsalud.org)
  • Subsequently, key questions on the treatment method of Korean medicine used for disc herniation in actual clinical trials were derived, and drafts of recommendations were formed after literature searches using the Grading of Recommendations, Assessment, Development and Evaluation. (bvsalud.org)
  • Fifteen recommendations for seven interventions for lumbar disc herniation were derived, along with the grade of recommendation and the level of evidence. (bvsalud.org)
  • The existing Korean medicine clinical practice guidelines for lumbar intervertebral disc herniation have been updated. (bvsalud.org)
  • Sath S. Does surgical decompression alleviate neglected cauda equina syndromes attributed to lumbar disc herniation and/or degenerative canal stenosis? (legehandboka.no)
  • A minimum of 5-year follow-up after lumbar transforaminal epidural steroid injections in patients with lumbar radicular pain due to intervertebral disc herniation. (legehandboka.no)
  • Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: two year results of a randomised controlled trial. (legehandboka.no)
  • As a disc degenerates, small bony outgrowths (bone spurs) may form at the edges of the affected vertebrae. (medlineplus.gov)
  • Over time, a degenerating disc may break down completely and leave no space between vertebrae, which can result in impaired movement, pain, and nerve damage. (medlineplus.gov)
  • Variants in genes that play roles in the development and maintenance of the intervertebral discs and vertebrae have also been found to be associated with intervertebral disc disease. (medlineplus.gov)
  • During the necropsy was observed intervertebral disc extrusion between L1-L2 vertebrae in a dog and between C3-C4 vertebrae in the other case with cartilaginous fragments in the spinal canal. (ufrgs.br)
  • An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. (web.app)
  • There can be a Aug 14, 2016 Intervertebral Disc Disease (IVDD) is a condition in which the spongy, shock absorbing disc, which resides between every back bone, extrudes Learn about degenerative disc disease, sciatica, and radiculopathy causes, situated between vertebrae, they are sometimes referred to as intervertebral discs. (web.app)
  • Intervertebral disc disease (IVDD) occurs when the cushioning intervertebral discs between the vertebrae of the spinal column become displaced, deteriorate, bulge out, rupture, or burst (herniate) into the spinal cord space. (vethub.info)
  • The vertebrae are connected by discs. (dogwheelchairlife.com)
  • The lumbar model includes a prolapsed inter-vertebral disc between the 3rd and 4th lumbar vertebrae. (southernbiological.com)
  • Disc extrusion (Hansen type I disc prolapse) located between T13 - L1 vertebrae. (vetrainorg.com)
  • Discs are the flat, round cushions between the vertebrae that absorb shock and prevent the vertebrae from grinding against each other. (axespt.com)
  • The discs are fluid-filled sacs that have a cushioning effect on the vertebrae by preventing them from rubbing against each other. (thehiddencures.com)
  • IVDD is a condition where intervertebral discs between a dog's spinal vertebrae bulge or burst. (djangobrand.com)
  • Two adjacent vertebrae are separated from each other by superior endplate, intervertebral disc, and inferior endplate. (springeropen.com)
  • Approaches to treating the condition include treatments that focus on removing the source of pain, for instance, the disc, reducing pain by stopping motion through vertebrae fusion, and more recent attempts to regenerate the disc using growth factors, gene therapy and stem cells (Taher, et al. (perfectbalanceclinic.com)
  • The vertebrae of the backbone are cushioned by intervertebral discs that act as shock absorbers and allow frictionless movement of your back. (socalbrainandspine.com)
  • The centre of the disc was replaced by a variable combination of fibrocartilage and hyaline cartilage, which appeared to develop from the collapsed inner lamellae of the annulus fibrosus. (massey.ac.nz)
  • In this condition, the annulus fibrosus (outer fibers) of the intervertebral disc is injured & the gelatinous material known as nucleus pulposus ruptures out of its enclosed space. (physiogain.com)
  • Degenerative changes occur in the disc and these changes cause softening of the nucleus and its fragmentation, weakening, and disintegration of the posterior part of the annulus fibrosus. (physiogain.com)
  • A cross-section of the intervertebral disc and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve. (smartimagebase.com)
  • Discs have a softer center known as the nucleus pulposus , which allows for mobility and absorption, and an outer ring of tough fibers called the annulus fibrosus that prevent the gel-like center from leaking out. (axespt.com)
  • Mercer S, Bogduk N. The ligaments and annulus fibrosus of human adult cervical intervertebral discs. (medscape.com)
  • Only 13% of the herniated discs studied were traced back to the annulus fibrosus , the outer part of the disc (1). (thespinepro.com)
  • A herniated disc is a condition in which the nucleus pulposus bulges out through the damaged or broken annulus fibrosus. (socalbrainandspine.com)
  • In intervertebral disc disease (IVDD) the A prolapsed (herniated) disc occurs when the outer fibres of the intervertebral disc are injured, and soft material, nucleus pulposus, enclosure ruptures. (web.app)
  • Information: telephone (box Celeb, Provides Social Media TipsBeth Gordon acquired a race-bred whippet after her mixed breed rescue developed IVDD (intervertebral disc disease). (web.app)
  • One of these health concerns is Intervertebral Disc Disease, or IVDD, which is most commonly found in smaller dogs. (vethub.info)
  • IVDD is sometimes referred to as a slipped or herniated disc. (vethub.info)
  • IVDD causes the discs to breakdown prematurely. (dogwheelchairlife.com)
  • Because dachshunds are prone to Intervertebral Disc Disease (IVDD) . (djangobrand.com)
  • Depending on the location of the affected disc or discs, intervertebral disc disease can cause periodic or chronic pain in the back or neck. (medlineplus.gov)
  • Intervertebral disc disease is estimated to affect about 5 percent of the population in developed countries each year. (medlineplus.gov)
  • Intervertebral disc disease results from a combination of genetic and environmental factors. (medlineplus.gov)
  • Researchers have identified variations in several genes that may influence the risk of developing intervertebral disc disease. (medlineplus.gov)
  • Normal variations in genes related to the body's immune function are also associated with an increased risk of developing intervertebral disc disease. (medlineplus.gov)
  • Researchers are working to identify and confirm other genetic changes associated with an increased risk of intervertebral disc disease. (medlineplus.gov)
  • Nongenetic factors that contribute to the risk of intervertebral disc disease are also being studied. (medlineplus.gov)
  • Intervertebral disc disease can run in families, but the inheritance pattern is usually unknown. (medlineplus.gov)
  • People with a first-degree relative (such as a parent or sibling) with intervertebral disc disease have an increased risk of developing the disorder themselves. (medlineplus.gov)
  • Individuals may inherit a gene variation that increases the risk of intervertebral disc disease, but do not inherit the condition itself. (medlineplus.gov)
  • Not all people with intervertebral disc disease have an identified gene variation that increases the risk, and not all people with such a gene variation will develop the disorder. (medlineplus.gov)
  • Farshad-Amacker NA, Farshad M, Winklehner A, Andreisek G. MR imaging of degenerative disc disease. (medscape.com)
  • Intervertebral disc replacement is a surgical technique for the treatment of lower back pain related to degenerative disc disease. (instron.com)
  • 7-9 The relationship between obesity and disc disease has not been proven. (cliniciansbrief.com)
  • Intervertebral disc disease is a usual neurological disorder in dogs, which the spinal cord is compressed by intervertebral disc extrusion or protrusion. (ufrgs.br)
  • Fibrocartilaginous embolic myelopathy isan acute infarction disease of spinal cord caused by fibrocartilaginous emboli histologically identical to the nucleus pulposus of intervertebral discs. (ufrgs.br)
  • The aim of this report is present two cases of fibrocartilaginous embolic myelopathy in dogs with intervertebral disc disease. (ufrgs.br)
  • In both cases, the presumptive diagnosis was intervertebral disc disease and surgical treatment was indicated. (ufrgs.br)
  • The simultaneous occurrence of intervertebral disc disease and the infarction of spinal cord in the proximate region accentuate the hypothesis that the etiology of fibrocartilaginous embolic myelopathy is mechanical into the vessels of the spinal cord. (ufrgs.br)
  • 2012-03-12 · Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. (web.app)
  • Degenerative Disc Disease at L4-L5 and L5-S1 Bulging Disc L4/L5 - Symptoms and Treatment (2020 Complete Foto. (web.app)
  • Arthroplasty versus fusion in singlelevel cervical degenerative disc disease. (web.app)
  • intervertebral disc disease (pressure on spinal cord that can cause paralysis), allergies and some skin problems (particularly if the dog's face wrinkles are not av O Frykman - LeCouteur R. A. Intervertebral Disk Disease. (web.app)
  • Sep 17, 2018 Lumbar (low back) degenerative disc disease (DDD) is a common condition in aging adults. (web.app)
  • In Type I, common in the mid-back Intervertebral disc disease nomenclature has changed over the years, and a familiarity with current definitions is essential if clear communication is to be achieved via radiology reports or referrals, especially as lumbar disc disease is a common problem and a source of a great deal of imaging. (web.app)
  • Bulging disc What is intervertebral disc disease? (web.app)
  • Microendoscopic discectomy (MED) is a minimally invasive spinal procedure being done successfully for prolapsed intervertebral disc disease. (who.int)
  • Describe in detail possible signs and symptoms in a patient that has intervertebral disc disease versus a musculoskeletal disorder. (distinctionessays.com)
  • Compared and contrasted the signs and symptoms of intervertebral disc disease and musculoskeletal disorder with reference to the given case. (distinctionessays.com)
  • Discussed the difference in treatment modalities between intervertebral disc disease and musculoskeletal disorder. (distinctionessays.com)
  • Intervertebral disc disease in dogs is an unfortunately common cause of back pain, hind end weakness and paralysis. (dogwheelchairlife.com)
  • Intervertebral disc disease comes in two distinct forms called, Hansen Type I and Hansen Type II. (dogwheelchairlife.com)
  • Dogs who develop Type II disc disease tend to be older large breed canines like German shepherds. (dogwheelchairlife.com)
  • The petite and lightweight shape of DJANGO's Adventure Dog Harness , in particular, is a favorite amongst customers with dogs recovering from back surgery and/or Intervertebral Disc Disease. (djangobrand.com)
  • Degenerative Disc Disease: Causes, Symptoms and Treatments. (perfectbalanceclinic.com)
  • While there are many possible causes, one of the most common is degenerative disc disease. (perfectbalanceclinic.com)
  • Furthermore, pain from degenerative disc disease is more likely to occur in people aged between 30 and 50 than it is in people aged 60 or older, as by the time people reach 60 the condition tends to have stabilised, a process that can take 20 to 30 years. (perfectbalanceclinic.com)
  • There are several causes of degenerative disc disease. (perfectbalanceclinic.com)
  • There is also a relationship between degenerative disc disease and smoking which is thought to relate to reduced blood flow to the disc. (perfectbalanceclinic.com)
  • Sometimes other conditions can give similar symptoms to degenerative disc disease. (perfectbalanceclinic.com)
  • Self-care is an important factor especially as when properly managed the pain associated with degenerative disc disease generally decreases as we grow older. (perfectbalanceclinic.com)
  • For most people, the best way of managing degenerative disc disease is through exercise and physical therapy. (perfectbalanceclinic.com)
  • Collagen and elastin crosslinks in human intervertebral discs and ligamentum flavum: age, gender and spinal level influences. (edu.au)
  • Since 1934, the terminology pertaining to lumbar spinal disc herniations has been confusing, inconsistent, and contradictory. (bradychiropracticgroupblog.com)
  • Lumbar disc injuries include an L2-3 disc bulge and L3-S1 disc herniations. (anatomicaljustice.com)
  • Schaufele MK, Hatch L, Jones W. Interlaminar versus transforaminal epidural injections for the treatment of symptomatic lumbar intervertebral disc herniations. (unifesp.br)
  • Prevalence of annular tears and disc herniations on MR images of the cervicalspine in symptom free volunteers. (medscape.com)
  • Over 90% of disc herniations are lumbar-based (2). (thespinepro.com)
  • Previous work suggests that cells isolated from the degenerate intervertebral disc have a very limited potential for regeneration, with a number of the cells necrotic and/or senescent. (aston.ac.uk)
  • Thus, this study was designed to assess the viability of cells present in surgical samples of degenerate intervertebral disc tissue.Methods: The technique for live/dead differentiation of cells used in this study utilises the fluorescent probes chloromethyl fluoresce in diacetate (CMFDA) and ethidium homodimer (EH). (aston.ac.uk)
  • Svenska synonymer Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates. (web.app)
  • It is a disc-shaped structure that lies between two adjacent vertebral bodies. (physiogain.com)
  • The intervertebral disc consists of a central nucleus pulposus, a peripheral annulus brosus, and cartilage endplates at the vertebral junctions. (perfectbalanceclinic.com)
  • This is the start of a process that continues with the degenerative destruction of the disc, endplates, and vertebral bodies. (perfectbalanceclinic.com)
  • This investigation compared the effectiveness of chemonucleolysis with 500 units of collagenase, to lateral fenestration of the thoracolumbar intervertebral discs of the non-chondrodystrophoid dog. (massey.ac.nz)
  • Concave type refer to the intervertebral disc tissue between the edge of the endplate and the straight line, flat type refer to the edge of the endplate coincides with the straight line, and irregular type refer to the vegetation outside the line. (scirp.org)
  • Specifically, the work will target the modelling and simulation of bottomup processes of tissue regulation, through which the dynamics of cell activity contributes to disc tissue turnover in specific regions of interest, in response to multifactorial cell stimulations. (esbiomech.org)
  • Eventually, collective cell activity will be linked with heterogeneous cell environments predictable through finite element simulations of disc tissue and organ multiphysics. (esbiomech.org)
  • This study confirms that C. acnes can stimulate the expression of IL-1 beta and other host molecules previously associated with pathological changes in disc tissue, including neo-innervation. (muni.cz)
  • SUMMARY OF BACKGROUND DATA: The intervertebral disc is the largest avascular tissue in the body. (ox.ac.uk)
  • The dissolving of the NUCLEUS PULPOSUS, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. (ouhsc.edu)
  • These mechanical attachments systems can help repair discectomy patients' reherniated intervertebral disc (IVD) post-surgery and promote natural tissue healing. (clemson.edu)
  • As we age, the water content of our tissue decreases, which causes intervertebral discs in our spines to become dehydrated and begin to collapse. (centracare.com)
  • In one study of herniated discs, extruded tissue from the soft center of the disc accounted for 29% of the cases. (thespinepro.com)
  • Evidence of intervertebral mechanical markers in chronic, non-specific low back pain (CNSLBP) is lacking. (springer.com)
  • Intervertebral Disc Chemolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "Intervertebral Disc Chemolysis" by people in this website by year, and whether "Intervertebral Disc Chemolysis" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "Intervertebral Disc Chemolysis" by people in Profiles. (ouhsc.edu)
  • Effects of artificial disc replacement with angles on stress of adjacent intervertebral disc]. (bvsalud.org)
  • To evaluate stress changes of intervertebral space and adjacent intervertebral space after artificial disc replacement with angles. (bvsalud.org)
  • The same loadings were applied on finite element models of normal cervical discs on C4-C6 segments, C4,5 segments with 0 degrees, C4,5 segments with 10 degrees, then stress changes of replaced segments space and adjacent segment space were observed. (bvsalud.org)
  • Artificial discs with 10 degrees have less influences on stress of adjacent intervertebral space and closer to mechanical property after being implanted into intervertebral space. (bvsalud.org)
  • The material that is extruded from the disc can compress neurons adjacent to the disc and cause pain. (thespinepro.com)
  • Severity and type of signs depend on the rate of disc extrusion/protrusion, volume of compressive mass/cord compression, and lesion location. (cliniciansbrief.com)
  • In the protrusion disc , the base of the displaced material is greater than the distance the disc material had moved towards the intervertebral foramen and/or the central neural canal. (bradychiropracticgroupblog.com)
  • Cartilage endplate and intervertebral disc were evaluated as follows. (scirp.org)
  • Running seems to be the most efficient activity for improving cardiovascular, building bone density, strengthening ankle, knee, and hip cartilage, and now strengthening intervertebral discs. (oregonexercisetherapy.com)
  • Science is now showing that not only do bones adapt to load, but so does cartilage and intervertebral discs (related to Davis's Law that explains how tendons, ligaments, and fascia adapt to mechanical stress). (oregonexercisetherapy.com)
  • Cyclical loading is now considered very important in developing, building, and maintaining knee cartilage growth, density, and strength and I believe future studies will show the importance of cyclical loading in developing, building, and maintaining intervertebral disc strength and resiliency. (oregonexercisetherapy.com)
  • Any repetitive movement can produce cyclical loading, but running produces more load than walking or cycling for example, and running has been shown to produce better bone density, cartilage density, and now intervertebral disc density than walking. (oregonexercisetherapy.com)
  • So if you want strong healthy muscles, bones, cartilage, and intervertebral discs do this running warmup and then go for a run. (oregonexercisetherapy.com)
  • Herniated discs often cause nerve pain called sciatica that travels along the sciatic nerve, which runs from the lower back down the length of each leg. (medlineplus.gov)
  • Distracted discs showed more BMP-2 (19.67 vs. 3.67 in 56 days compression) and collagen 2 (18.67 vs. 11.33 in 56 days compression) positive cells per field. (nih.gov)
  • Distraction results in disc rehydration, stimulated extracellular matrix gene expression, and increased numbers of protein-expressing cells. (nih.gov)
  • Furthermore, a positive correlation was observed between the SDF-1 IOD value and the percentage of CXCR4-positive disc cells in the nucleus pulposus and cartilaginous endplate. (medsci.org)
  • In this study the authors examined the capacity of ovine mesenchymal precursor cells (MPCs) to restore the extracellular matrix of degenerate discs in an ovine model. (thejns.org)
  • Three months after cABC injection, the L3-4 discs of all animals were injected with either a high dose (4 × 10 6 cells, in 12 sheep) or low dose (0.5 × 10 6 cells, in 12 sheep) of MPCs suspended in hyaluronic acid (HA). (thejns.org)
  • Purpose: The intervertebral disc is dependent on the extracellular matrix for its function, which is produced and maintained by the resident cells. (aston.ac.uk)
  • Cell viability was analysed by counting at least 200 cells from a minimum of five fields of view.Results: To date 21 surgical disc samples from patients, aged 17-57 years,have been examined. (aston.ac.uk)
  • Cells in these discs commonly occur in clusters (approximately 54% of disc cells are clustered). (aston.ac.uk)
  • Dead cells, when they did occur, were predominantly seen around the periphery of the disc sections which may be derived from trauma during dissection.Conclusions: In contrast to reports in the literature, these results indicate that the viability of cells from the herniated disc may be adequate to consider for utilising in biological therapies. (aston.ac.uk)
  • Interestingly, a greater proportion of clustered cells appear to be viable compared to single cells.Additionally we plan to investigate whether there is any relationship between cell viability and the pathology, duration of symptoms or age of patient, as this may serve as an indicator of the suitability of degenerate discs for cell therapy. (aston.ac.uk)
  • NP cells produce most of the major components of the extracellular matrix, including Collagen II and aggrecan, which are essential for the integrity of disc structure [ 6 , 7 ]. (aging-us.com)
  • To investigate this, we examined the upregulation of IL-1 beta, and other known IL-1 beta-induced inflammatory markers and neurotrophic factors, from nucleus-pulposus-derived disc cells infected in vitro with C. acnes for up to 48 h. (muni.cz)
  • Upon infection, significant upregulation of IL-1 beta, alongside IL-6, IL-8, chemokine (C-C motif) ligand 3 (CCL3), chemokine (C-C motif) ligand 4 (CCL4), nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), was observed with cells isolated from the degenerative discs of eight patients versus non-infected controls. (muni.cz)
  • Nutrients necessary for cellular survival diffuse from the blood supply around the disc margins to the cells. (ox.ac.uk)
  • RESULTS: The model predicted that concentrations of oxygen and glucose, which are consumed by cells, fell towards the disc center. (ox.ac.uk)
  • In contrast, the concentration of lactate, produced by the cells, was highest in the center and fell towards the disc-blood vessel interface. (ox.ac.uk)
  • IVD progenitor cells: a new horizon for understanding disc homeostasis and repair. (channel969.com)
  • Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. (channel969.com)
  • The natural polyphenol epigallocatechin gallate protects intervertebral disc cells from oxidative stress. (channel969.com)
  • The growth of intervertebral disc cells in monolayer culture. (biomedcentral.com)
  • Nondegenerate discs showed few immunopositive cells. (shu.ac.uk)
  • CONCLUSIONS: Finite element methods can be used to predict concentration gradients of solutes throughout the disc in relation to changes in disc and endplate morphology, disc properties, and cellular activities. (ox.ac.uk)
  • The intervertebral disc extrusion occurs predominantly in dogs with age between three and six years old, in the cervical, thoracolumbar (T11-L3) and lumbar regions. (ufrgs.br)
  • A massive dorsal extrusion of nuclear material was observed in one disc at post-mortem in this dog and was believed to be the cause of the paralysis. (massey.ac.nz)
  • In the extrusion disc , the greatest measure of the displaced disc material is greater than the measure of the base of the displaced material. (bradychiropracticgroupblog.com)
  • BACKGROUND: Lumbar disc prolapse is a common problem and the current surgical standard for its treatment is a microsurgical discectomy. (who.int)
  • Complications included dural puncture with K-wire (1), dural tear (2), superficial wound infection (1), discitis (1) and recurrent disc prolapse (2). (who.int)
  • In most of the cases, around 80% to 90% of the cases, prolapsed discs settled by themselves, and their symptoms almost disappear. (physiogain.com)
  • Diagnosing the root cause of your herniated disc requires a full patient history, clearly defined pain symptoms and a series of physical tests that will help your doctor locate the herniated disc. (thespinepro.com)
  • Biological repair of intervertebral disc. (rush.edu)
  • An HS, Thonar EJ, Masuda K. Biological repair of intervertebral disc. (rush.edu)
  • The pressure induced by a herniated disc or bone spur on nerve roots, ligaments or the spinal cord may cause pain in the neck and/or arms, numbness or weakness in the arms, forearms or fingers, and lack of coordination. (socalbrainandspine.com)
  • This causes the disc to bulge or rupture and put too much pressure on the spinal cord. (dogwheelchairlife.com)
  • Most commonly occurs at the posterior-lateral region of the intervertebral disc. (physiogain.com)
  • nucleus pulposus comes out of annulus and lies under the posterior longitudinal ligament, but doesn't lose contact with the parent disc. (physiogain.com)
  • This joint is also sometimes referred to as the apophyseal joint or the posterior intervertebral joint. (medscape.com)
  • In the US, twenty-eight percent of people over forty will experience a disc abnormality. (thespinepro.com)
  • Materials and Methods: Ten herniated discs of five dogs were treated with percutaneous injection of an O 2 -O 3 gas mixture with O 3 concentration of 32 μg/μl intradiscally (1.5-2 μl) under fluoroscopy guidance. (iiarjournals.org)
  • MATERIALS AND METHODS: 107 patients with prolapsed lumbar intervertebral disc who were seen at our institution between November 2002 and January 2006 were included in the study. (who.int)
  • We investigated the expression of SDF-1 and CXCR4 in intervertebral discs (IVDs). (medsci.org)
  • Did you know that your spinal column's spongy intervertebral discs (IVDs) comprise 25% of this segmented structure's entire length? (chiropracticsolutions.org)
  • The number of complaints of low back pain, diagnosis of herniated disc and often referral for unnecessary surgical interventions highlights the need for a better assessment of patients with this type of complaint. (bvsalud.org)
  • Samples of herniated discs were obtained from patients undergoing routine discectomy and processed within 2 hours of excision. (aston.ac.uk)
  • IMSEAR at SEARO: Microendoscopic discectomy for prolapsed lumbar intervertebral disc. (who.int)
  • Ranjan A, Lath R. Microendoscopic discectomy for prolapsed lumbar intervertebral disc. (who.int)
  • CONCLUSIONS: Microendoscopic Discectomy (MED) is a safe and effective procedure for the treatment of prolapsed lumbar intervertebral disc. (who.int)
  • A cervical discectomy or decompressive spinal procedure is an operative procedure that relieves pressure on the spinal nerves and/or spinal cord by partially or completely removing the intervertebral disc that is herniated and/or bony material (bone spur). (socalbrainandspine.com)
  • Harmful effects include increased oxygen consumption and pulmonary ventilation, difficulty in maintaining steady posture, changes in bone structure involving spondylitis deformations, intervertebral osteochondrosis, and calcification of the intervertebral discs and Schmorl's nodes. (cdc.gov)
  • Since intervertebral disc protrusions occur more commonly in chondrodystrophoid breeds of dog, the effect of collagenase should be studied in degenerate disc of these breeds before it can be recommended for clinical use. (massey.ac.nz)
  • The water content of the disc decreases with the result that assures in the nucleus pulposus and sometimes the annulus brosus potentially can occur. (perfectbalanceclinic.com)
  • Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? (ox.ac.uk)
  • Intervertebral disc (IVD) is a leading source of Low back pain (LBP). (cdc.gov)
  • A herniated disc can also cause back pain. (thehiddencures.com)
  • Can exercise benefit the intervertebral disc in non-specific low back pain sufferers? (drjoannagarvey.com)
  • Wong pointed out that non-specific low back pain patients who responded with greater than 30% relief to spinal manipulation therapy compared with non-responders demonstrated a higher apparent diffusion coefficient for diffusion of water into the disc. (drjoannagarvey.com)
  • At the very least, a Tonawanda back pain sufferer may well improve the chances of responding to conservative care by maximizing the water content of disc with exercise and spinal manipulation ! (drjoannagarvey.com)
  • Studies of manual therapy and traction effects on the intervertebral disc in back pain patients documented that there is an effect on the physiology (the structure and function) of the disc mainly via water diffusion and molecular transport . (drjoannagarvey.com)
  • While it is well-known that mechanical signals can either promote or disrupt intervertebral disc (IVD) homeostasis, the molecular mechanisms for transducing mechanical stimuli are not fully understood. (biorxiv.org)
  • Between each bone is the intervertebral disc. (thehiddencures.com)
  • Researchers described how muscles, tendons and bone do respond well, so they looked at the disc to see if it does. (drjoannagarvey.com)
  • The sources of compression such as bone spurs and/or disc material are removed. (socalbrainandspine.com)
  • An intervertebral disc is also composed of an outer annulus which surrounds an inner gel-like center, i.e., the nucleus pulposus. (springeropen.com)
  • When the outer section of the disc is weakened or worn down, it can tear open or herniate which allows the soft center of the disc, the nucleus pulposus, to leak through the rigid outer fibers (annulus fibrosis). (thespinepro.com)
  • Major non-surgical treatments (Up to 90% of the intervertebral disc problems can be treated without surgery! (knieprobleme.at)
  • The "era of the intervertebral disc" began in 1934 when William Jason Mixter and Joseph Seaton Barr read their paper, Rupture of the Intervertebral Disc with Involvement of the Spinal Canal , to the Annual Meeting of the New England Surgical Society (1). (bradychiropracticgroupblog.com)
  • Hemilaminectomy surgical procedure to remove the herniated disc with expected recovery period upto 3 months. (vetrainorg.com)