A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
The region of the lower limb between the FOOT and the LEG.
The inferior part of the lower extremity between the KNEE and the ANKLE.
Comparison of the BLOOD PRESSURE between the BRACHIAL ARTERY and the POSTERIOR TIBIAL ARTERY. It is a predictor of PERIPHERAL ARTERIAL DISEASE.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.
The main artery of the thigh, a continuation of the external iliac artery.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Compounds that specifically inhibit PHOSPHODIESTERASE 3.
Narrowing of the spinal canal.
A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
Elements of limited time intervals, contributing to particular results or situations.
Either of two fleshy protuberances at the lower posterior section of the trunk or HIP in humans and primate on which a person or animal sits, consisting of gluteal MUSCLES and fat.
Radiography of blood vessels after injection of a contrast medium.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
The cavity within the SPINAL COLUMN through which the SPINAL CORD passes.
Operative procedures for the treatment of vascular disorders.
The flow of BLOOD through or around an organ or region of the body.
Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A potent vasodilator agent that increases peripheral blood flow.
Compounds that increase urine volume by increasing the amount of osmotically active solute in the urine. Osmotic diuretics also increase the osmolarity of plasma.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Drugs used to cause dilation of the blood vessels.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
The condition of an anatomical structure's being constricted beyond normal dimensions.
The measurement and recording of MOTOR ACTIVITY to assess rest/activity cycles.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.

Superficial femoral eversion endarterectomy combined with a vein segment as a composite artery-vein bypass graft for infrainguinal arterial reconstruction. (1/786)

OBJECTIVE: The purpose of this study was to determine the results of composite artery-vein bypass grafting for infrainguinal arterial reconstruction. METHODS: This study was designed as a retrospective case series in two tertiary referral centers. Forty-eight of 51 patients underwent the procedure of interest for the treatment of ischemic skin lesions (n = 42), rest pain (n = 3), disabling claudication (n = 1), and infected prosthesis (n = 2). The intervention used was infrainguinal composite artery-vein bypass grafting to popliteal (n = 18) and infrapopliteal (n = 30) arteries, with an occluded segment of the superficial femoral artery prepared with eversion endarterectomy and an autogenous vein conduit harvested from greater saphenous veins (n = 43), arm veins (n = 3), and lesser saphenous veins (n = 2). The main outcome measures, primary graft patency rates, foot salvage rates, and patient survival rates, were described by means of the life-table method for a mean follow-up time of 15.5 months. RESULTS: The cumulative loss during the follow-up period was 6% and 24% at 6 and 12 months, respectively. The primary graft patency rates, the foot salvage rates, and the patient survival rates for patients with popliteal grafts were 60.0% +/- 9.07%, 75.7% +/- 9.18%, and 93.5% +/- 6.03%, respectively, at 1 month; 53.7% +/- 11.85%, 68.9% +/- 12.47%, and 85. 0% +/- 9.92% at 1 year; and 46.7% +/- 18.19%, 68.9% +/- 20.54%, and 53.1% +/- 17.15% at 5 years. For infrapopliteal grafts, the corresponding estimates were 72.4% +/- 7.06%, 72.9% +/- 6.99%, and 92.7% +/- 4.79% at 1 month; 55.6% +/- 10.70%, 55.4% +/- 10.07%, and 77.9% +/- 9.02% at 1 year; and 33.6% +/- 22.36%, 55.4% +/- 30.20%, and 20.8% +/- 9.89% at 5 years. CONCLUSION: The composite artery-vein bypass graft is a useful autogenous alternative for infrainguinal arterial reconstruction when a vein of the required quality is not available or when the procedure needs to be confined to the affected limb.  (+info)

Popliteal artery occlusion as a late complication of liquid acrylate embolization for cerebral vascular malformation. (2/786)

Occlusion of arteriovenous malformations of the brain (BAVMs) by means of an endovascular approach with liquid acrylate glue is an established treatment modality. The specific hazards of this procedure are related to the central nervous system. In the case of unexpectedly rapid polymerization of the cyanoacrylate glue and adhesion of the delivering microcatheter to the BAVM, severing the catheter at the site of vascular access is considered an acceptable and safe management. We present a unique complication related to this technique that has not been described yet. Fragmentation and migration of the microcatheter, originally left in place, had caused popliteal artery occlusion, which required saphenous vein interposition, in a 25-year-old man. Suggestions for avoiding this complication are discussed.  (+info)

Peripheral blood flow rates and microvascular responses to orthostatic pressure changes in claudicants before and after revascularisation. (3/786)

OBJECTIVES: To study the effect of arterial reconstruction for occlusive atherosclerotic disease with intermittent claudication on blood flow rate during rest and on microvascular responses to orthostatic pressure changes in the pulp skin of the first toe where arteriovenous anastomoses are numerous. MATERIAL: Eleven patients with Fontaine IIa claudication (ankle blood pressure index > 0.30) before and 7 (range: 2-11) months after intervention. METHODS: Blood flow rate was measured by the heat washout method with the toe at heart level and after passive lowering to 50 cm below this level using a Clark type electrode with thermostatically controlled cap that was fixed to the pulp of the first toe by adhesive tape. RESULTS: At heart level, blood flow rate was lower in claudicants before reconstruction as compared to a group of previously published control subjects (p = 0.0076, Wilcoxon), blood flow rate increased in claudicants from before to after intervention (p = 0.0128), and postoperative blood flow rate was like that of normals (N.S.). Before surgery, blood flow rate in claudicants increased in median with a factor of 1.79 during lowering (p < 0.0051). CONCLUSIONS: The disturbance of the microcirculatory responses to orthostatically induced pressure changes in claudicants reverted towards normal after arterial reconstruction.  (+info)

Spontaneous popliteal artery dissection: a case report and review of the literature. (4/786)

Spontaneous arterial dissection of a peripheral artery involving an extremity is a rare event. We report a case of atraumatic, nonaneurysmal dissection of the popliteal artery that occurred in a 62-year-old man who was admitted with progressive right lower-extremity claudication. Preoperative arteriography was suggestive of arterial dissection, and surgical treatment was undertaken before irreversible ischemia developed. Intraoperatively, a dissection of the popliteal artery was observed, and the patient underwent femoral-popliteal bypass grafting with the ipsilateral, greater saphenous vein and the popliteal artery was ligated distal to the dissection. Spontaneous dissection limited to the popliteal artery has not previously been reported in the literature. Successful management depends on consideration of the diagnosis, particularly when other, more common diseases have been excluded.  (+info)

Leg symptoms, the ankle-brachial index, and walking ability in patients with peripheral arterial disease. (5/786)

OBJECTIVE: To determine how functional status and walking ability are related to both severity of lower extremity peripheral arterial disease (PAD) and PAD-related leg symptoms. DESIGN: Cross-sectional study. SETTING: Academic medical center. PARTICIPANTS: Patients aged 55 years and older diagnosed with PAD in a blood flow laboratory or general medicine practice (n = 147). Randomly selected control patients without PAD were identified in a general medicine practice (n = 67). MEASUREMENTS: Severity of PAD was measured with the ankle-brachial index (ABI). All patients were categorized according to whether they had (1) no exertional leg symptoms; (2) classic intermittent claudication; (3) exertional leg symptoms that also begin at rest (pain at rest), or (4) exertional leg symptoms other than intermittent claudication or pain at rest (atypical exertional leg symptoms). Participants completed the 36-Item Short-Form Health Survey (SF-36) and the Walking Impairment Questionnaire (WIQ). The WIQ quantifies patient-reported walking speed, walking distance, and stair-climbing ability, respectively, on a scale of 0 to 100 (100 = best). MAIN RESULTS: In multivariate analyses patients with atypical exertional leg symptoms, intermittent claudication, and pain at rest, respectively, had progressively poorer scores for walking distance, walking speed, and stair climbing. The ABI was measurably and independently associated with walking distance (regression coefficient = 2.87/0.1 ABI unit, p =.002) and walking speed (regression coefficient = 2.09/0.1 ABI unit, p =.015) scores. Among PAD patients only, pain at rest was associated independently with all WIQ scores and six SF-36 domains, while ABI was an independent predictor of WIQ distance score. CONCLUSIONS: Both PAD-related leg symptoms and ABI predict patient-perceived walking ability in PAD.  (+info)

Quality of life associated with varying degrees of chronic lower limb ischaemia: comparison with a healthy sample. (6/786)

OBJECTIVES: To assess quality of life in patients with varying degrees of ischaemia in comparison with controls, and to determine whether the degree of lower limb ischaemia and sense of coherence were associated with quality of life. MATERIALS AND METHODS: 168 patients, including 93 claudicants and 75 patients with critical ischaemia and 102 controls were studied. Quality of life was assessed using the Nottingham Health Profile in addition to the Sense of Coherence scale. MAIN RESULTS: Patients with lower limb ischaemia scored significantly reduced quality of life in all aspects compared to controls. Pain, physical mobility and emotional reactions were the significant independent factors when using logistic regression analysis. The grade of disease and low sense of coherence were significantly associated with low quality of life. Increasing lower limb ischaemia significantly conferred worse pain, sleeping disturbances and immobility. CONCLUSION: This study showed that the quality of life was impaired among patients with lower limb ischaemia, in all investigated respects. The degree to which quality of life was affected seems to represent an interplay between the grade of ischaemia and the patient's sense of coherence. This suggests the need for a multidimensional assessment prior to intervention.  (+info)

Thermal biofeedback for claudication in diabetes: a literature review and case study. (7/786)

Temperature biofeedback (TBFB) is designed to alter cutaneous temperature in treated extremities by providing information corresponding to minor temperature fluctuations in the context of therapeutic structure and reinforcement. Toe TBFB may improve vascular flow and walking tolerance in patients with peripheral vascular disease. This case study documents improved walking in a diabetes patient with lower extremity complications, and suggests TBFB might increase lower extremity temperature and blood flow volume pulse in uncomplicated diabetes. Ankle-brachial index (ABI) and walking function were assessed in a 60-year-old woman with type 2 diabetes and intermittent claudication, before and after five sessions of TBFB applied to the ventral surface of the great toe. Toe temperature increased during feedback phases but not during baseline phases. Improvements were seen in ankle-brachial index, walking distance, walking speed, and stair climbing. This case indicates the need for extended and controlled study of TBFB for improved vascular and ambulatory function in diabetic claudication.  (+info)

Measuring serum total cholesterol: do vascular surgeons know what they are doing? (8/786)

Raised serum total cholesterol (TC) is an accepted risk factor for both coronary and peripheral vascular disease and three landmark trials have shown the benefit of lowering TC using statins. Vascular surgeons tend to measure TC, but little is known about how they manage hypercholesterolaemia or whether they believe treatment will be of benefit. A questionnaire was sent to listed members of the Vascular Surgical Society of Great Britain and Ireland seeking responses to a range of questions on the measurement and management of raised TC. In all, 374 questionnaires were sent out. The response rate was 67%. Over 90% of respondents said they measured TC and considered a level below 5.5 mmol/l as normal. The cut-off for initiating drug therapy, referral to a dietician or to a lipid specialist varied from 5.5 to 7.5 mmol/l. Most (62%) believed that lowering TC improved coronary mortality, but fewer (26%) that it prevented worsening of claudication. Although most vascular surgeons check for raised TC, the level at which treatment begins and the form it takes varies; in many cases being at odds with recommendations. Few surgeons are convinced of the benefits of lowering TC for claudication and nearly one-fifth do not believe it improves coronary mortality.  (+info)

Intermittent claudication, according to the Fontaine classification, is a classical symptom of stage II peripheral arterial occlusive disease (PAOD) of the lower limbs. It results from the progression of atherosclerosis leading to the narrowing and complete occlusion of arteries. It manifests with pain in the muscles of the lower limbs which forces the patients to interrupt their current activity. Supervised treadmill training is believed to lead to the most favourable outcomes in the form of improved pain-free walking distance and maximum walking distance. The improvement in pain related to intermittent claudication and in functional performance are probably the combined effect of various mechanisms in response to the exercise training. The most important mechanisms include: improved skeletal muscle metabolism, favourable haemorheologic changes, delayed progression of atherosclerosis, peripheral blood flow adaptation, improved economics of walking, and changed perception of pain. The role of ...
Rationale: We recently reported that ramipril more than doubled walking times in peripheral artery disease patients with intermittent claudication. Objective: To conduct exploratory analyses of the effects of ramipril therapy on circulating biomarkers of angiogenesis/arteriogenesis, thrombosis, inflammation and leukocyte adhesion in patients with intermittent claudication. Methods and Results: 165 patients with intermittent claudication (mean (SD), 65.3 (6.7) years), were administered ramipril 10mg/d (n=82) or matching placebo (n=83) for 24 weeks, in a randomized, double-blind study. Plasma biomarkers of angiogenesis/arteriogenesis (vascular endothelial growth factor, VEGF-A; fibroblast growth factor, FGF-2), thrombosis (D-dimer; von Willebrand Factor, vWF; thrombin-antithrombin III, TAT), inflammation (high sensitivity C-reactive protein, hsCRP; osteopontin, OPN), and leukocyte adhesion (soluble vascular cell adhesion molecule-1, sVCAM-1; soluble intracellular adhesion molecule-1, sICAM-1) were ...
Intermittent claudication is pain in the legs due to muscle ischaemia associated with arterial stenosis or occlusion. Angioplasty is a technique that involves dilatation and recanalisation of a stenosed or occluded artery. The objective of this review was to determine the effects of angioplasty of arteries in the leg when compared with non surgical therapy, or no therapy, for people with mild to moderate intermittent claudication. Sources searched include the Cochrane Peripheral Vascular Diseases Groups Specialized Trials Register (August 2006), the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 3, 2006) and reference lists of relevant articles. The review authors also contacted investigators in the field and handsearched relevant conference proceedings (August 2006). Randomised trials of angioplasty for mild or moderate intermittent claudication. The contact author selected suitable trials and this was checked by the other review author. Both review authors assessed trial ...
NM-702 oral tablets are being developed for the treatment of Intermittent Claudication, a primary early stage indication of peripheral arterial disease (PAD). This trial is designed to assess the safety and efficacy of 4 mg and/or 8 mg NM-702 taken twice a day (BID) for 24 weeks to see if it improves peak walking time (PWT) more than placebo for the treatment of Intermittent Claudication ...
Peripheral Angioplasty in Hyderabad. Cost of Peripheral Angioplasty in Hyderabad, View List of Best Reviewed Hospitals & Surgeons & Book Appointment, Patient Reviews, Peripheral Angioplasty Meaning, Risks, Side Effects & FAQ. | Practo
Intermittent claudication is a predictable pattern of lower leg pain caused by inadequate blood flow to exercising muscle.### The pain of intermittent claudication has three characteristics: It is a cramping pain in the calves that is brought on
The Doctors Medical Library. Health and Healing Information. Physician, Health care help, Intermittent claudication is an aching, crampy, tired, and sometimes burning pain in the legs that comes and goes. It typically occurs with walking and goes away with rest and is due to poor circulation of blood in the arteries of the legs. In very severe claudication the pain is also felt ar rest. Intermittent claudication may occur in one or both legs and often continues to worsen over time. However, some people complain only of weakness in the legs when walking or a feeling of tiredness in the buttocks. Impotence is an occasional related complaint in men. The usually intermittent nature of the pain is due to narrowing of the arteries that supply the leg with blood, limiting the supply of oxygen to the leg muscles, a limitation that is felt especially when the oxygen requirement of these muscles rises with exercise. Intermittent claudication can be due to temporary artery narrowing due to vasospasm (spasm of
This article describes the development of the Claudication Symptom Instrument (CSI) and its measurement properties for evaluating the symptom experience of patients diagnosed with intermittent claudication (IC). We conducted semi-structured qualitative interviews with IC patients for item development and cognitive interviews in which patient comprehension of items was tested. We evaluated measurement properties using data collected and analyzed in the context of an observational comparative effectiveness study of IC treatments. Items measuring five symptom important to patients were developed and cognitively tested: Pain, Numbness, Heaviness, Cramping, and Tingling. Item means (higher means worse) ranged from 1.1 (Tingling) to 2.3 (Pain) (range: 0 none to 4 extreme). Rasch analysis yielded support for an overall score (χ
BACKGROUND:. Peripheral arterial disease (PAD) is a major source of morbidity and mortality, particularly in older individuals. Despite its high prevalence, clinicians often fail to diagnose PAD, particularly in patients who do not have classic claudication symptoms. Even in those individuals with documented PAD, cardiac risk factors are not often aggressively treated, and only a minority of patients receive pharmacologic therapy with cilostazol. Although there is a growing body of literature demonstrating the value of exercise rehabilitation in individuals with peripheral vascular disease and claudication, exercise rehabilitation is not often prescribed as supervised exercise rehabilitation for claudication, is not reimbursed by Medicare, and is rarely covered by private insurance. Therefore, few individuals with PAD and intermittent claudication have access to supervised exercise rehabilitation.. The use of surgical intervention and stent placement to improve blood flow in patients who do not ...
Exercise training improves walking tolerance in patients with peripheral arterial disease (PAD).1-8 Typically this includes walking as the principal mode of training.4,5 Patients with PAD who walk with pain have greater improvements in walking distances than those who walk only to the point at which pain begins.6,7 However, forcing patients with PAD to walk with increasing pain is challenging as because of their personality type they tend to experience negative emotions more readily than people without PAD.9 They may therefore not tolerate pain well, which could lead to poor attendance at training sessions. However, no studies have specifically examined the relationship between prescription of exercise likely to cause pain and compliance with exercise programmes. Walker et al. found that a 6-week pain-free upper limb cycle ergometry exercise training programme and lower limb cycling training produced equal improvements in maximal walking distance (MWD) and pain-free walking distance (PFWD).1 ...
TY - JOUR. T1 - Impaired balance and higher prevalence of falls in subjects with intermittent claudication. AU - Gardner, Andrew. AU - Montgomery, P. S.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Background. The purpose of this study was to determine whether peripheral arterial disease (PAD) subjects have impaired balance and a higher prevalence of falls than non-PAD controls and to determine whether balance and falls are related to the severity of PAD and functional status. Methods. A total of 367 PAD subjects (aged 68 ± 1 years; mean ± SEM) and 458 non-PAD controls (aged 67 ± 1 years) were recruited. Unipedal stance time, history of ambulatory stumbling and unsteadiness, and history of falling were recorded. Additionally, subjects were characterized on age, ankle/brachial index (ABI), anthropometry, measured and self-reported ambulatory function, and monitored daily physical activity. Results. Unipedal stance time was 28% shorter (p , .001) in the PAD subjects than in the non-PAD controls (15.9 ± ...
Chien-An Hsieh, Shing-Hsien Chou, I-Chih Chen, Shih-Jung Jang, Hsin-Hua Chou, Yu-Lin Ko, Hsuan-Li Huang Background: The efficacy of drug-coated balloons (DCBs) in critical limb ischemia (CLI) is unclear. To investigate the clinical characteristics and outcomes of DCBs in symptomatic femoropopliteal disease between patients with intermittent claudication (IC) and CLI. Methods: Data were retrospectively collected from three centers in Taiwan on patients who received…
Intermittent claudication is a pain in the calf due to a lack of blood needed to supply those muscles with oxygen during exercise or movement, ultimately resulting in the person to slow or stop movement. It is the most common presenting symptom for people with long-standing lower limb arterial disease resulting from narrowing of the arteries that supply the lower limbs with blood. This narrowing most commonly occurs through the process of atherosclerosis in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol and triglycerides. People with mild lower limb arterial disease are advised to stop smoking, exercise, and take an antiplatelet agent to prevent heart attack or stroke. Medication to improve walking distance is only of limited value.. Omega-3 fatty acids are a type of fatty acid found in fish oils, eggs, fruits and vegetables. They are essential nutrients, as the body cannot make omega-3 fatty acids by itself. It is thought that omega-3 fatty ...
TY - JOUR. T1 - A cilostazol hatásmechanizmusa és szerepe a perifériás veroérbetegség kezelésében. AU - Koltai, Katalin. AU - Biró, Katalin. AU - Kovács, Dávid. AU - Csiszár, Beáta. AU - Tóth, Kálmán. AU - Késmárky, Gábor. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Intermittent claudication is a typical symptom of lower extremity arterial disease. Cilostazol is a reversible, selective phosphodiesterase-3 inhibitor which has antiplatelet, antithrombotic and vasodilator effects. It is indicated to improve maximal and pain-free walking distance in patients with intermittent claudication in the absence of rest pain or peripheral tissue necrosis. It can be beneficial in diabetic patiens with intermittent claudication, as it has been proved to prevent the development of foot ulcers. In combination with acetyl-salicylic acid it may help maintain stent patency after endovascular intervention and stent implantation. Cilostazol is contraindicated in heart failure. With cilostazol, a clinically ...
Exercise can improve symptoms, as can revascularization.[4] Both together may be better than one intervention of its own.[4] Pharmacological options exist, as well. Medicines that control lipid profile, diabetes, and hypertension may increase blood flow to the affected muscles and allow for increased activity levels. Angiotensin converting enzyme inhibitors, adrenergic agents such as alpha-1 blockers and beta-blockers and alpha-2 agonists, antiplatelet agents (aspirin and clopidogrel), naftidrofuryl, pentoxifylline, and cilostazol (selective PDE3 inhibitor) are used for the treatment of intermittent claudication.[5] However, medications will not remove the blockages from the body. Instead, they simply improve blood flow to the affected area.[6] Catheter-based intervention is also an option. Atherectomy, stenting, and angioplasty to remove or push aside the arterial blockages are the most common procedures for catheter-based intervention. These procedures can be performed by interventional ...
Objective: To review the evidence for efficacy of three contemporary treatments for intermittent claudication: pentoxifylline, exercise programs, and smoking cessation.. Data Identification: English-language literature search using MEDLINE, Index Medicus, and bibliographic reviews of major texts and all pertinent articles.. Study Selection: For pentoxifylline, randomized, double-blind controlled trials were selected. For exercise, all controlled trials were selected, because few randomized trials have been done. For smoking cessation, 26 pertinent studies were selected after an exhaustive search.. Data Extraction: Study quality was evaluated; therapeutic efficacy was estimated for pentoxifylline and exercise using meta-analytic techniques. For smoking cessation, all outcomes were determined and described.. Results: For pentoxifylline, insufficiently reported data led to marked disparity in effect sizes, preventing a meaningful pooled estimate of effectiveness. The results for exercise therapy ...
Reversal of Lower Extremity Intermittent Claudication and Rest Pain by Hydration Samuel Fernández et al Annals of Vascular Surgery Article in Press...
Learn more about Intermittent Claudication at Grand Strand Medical Center Related Terms: Peripheral Vascular Disease Uses Principal Proposed Natural Treatments ...
It is a clinical diagnosis given for muscle pain (ache, cramp, numbness or sense of fatigue), in the calf muscle, which occurs during exercise, walking, and is relieved by a short period of rest....
Intermittent claudication is a disorder of an artery that causes muscle pain and is particularly common in the calf muscle group. Read more here.
801. I was told in rapid succession that I was suffering from intermittent claudication (thats blocked arteries in the legs), high blood pressure, Diabetes Type 2. and that I was overweight.. Not a lot of pleasure there! The intermittent claudication made it increasingly difficult to do much, so that in effect I had become a prisoner to my house and garden. Exercise was out of the question, my legs simply couldnt cope, but it was hoped that angioplasty to each leg would cure t…. diabetes,diabetic,blood sugar,type 2 diabetes,diet. I was told in rapid succession that I was suffering from intermittent claudication (thats blocked arteries in the legs), high blood pressure, Diabetes Type 2. and that I was overweight.. Not a lot of pleasure there! The intermittent claudication made it increasingly difficult to do much, so that in effect I had become a prisoner to my house and garden. Exercise was out of the question, my legs simply couldnt cope, but it was hoped that angioplasty to each leg ...
Intermittent claudication is the name given to cramping or aching leg pain that occurs during exercise (such as walking) and is relieved by rest.
Discover 1 possible causes for hair loss, hip pain, intermittent claudication, joint pain including Systemic Lupus Erythematosus (SLE)
Review of the adaptation of skeletal muscle in intermittent claudication. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Intermittent claudication (IC) occurs due to poor blood circulation in the legs. It manifests through aching, burning pain and a sensation of heaviness
Regensteiner JG, Ware JE, McCarthy WJ, Zhang P, Forbes WP, Heckman J, Hiatt WR. Effect of cilostazol on treadmill walking, community-based walking ability, and health-related quality of life in patients with intermittent claudication due to peripheral arterial disease: meta-analysis of six randomized controlled trials. J Am Geriatr Soc. 2002 Dec; 50(12):1939-46 ...
This study tested the psychometric properties of the Walking Impairment Questionnaire (WIQ) in overweight patients with osteoarthritis (OA) of the knee.
1. The activities of phosphofructokinase (PFK), citrate synthetase (CS), lactate dehydrogenase (LDH), 3-hydroxyacyl-CoA dehydrogenase (ACDH) and cytochrome- c oxidase (Cyt-ox) in the calf muscle tissue were compared in subjects with intermittent claudication ( n = 38) and controls ( n = 20). The activities of CS, ACDH and Cyt-ox were increased and the activity of Cyt-ox was positively correlated to the maximal walking distance (MWD) in the patients. 2. Thirty-three patients with intermittent claudication were randomized to three treatment groups: (1) operative surgery, (2) operative surgery supplemented with physical training and (3) physical training alone. Before and after 6-12 months of treatment, symptom-free walking distance (SFWD), MWD, ankle-brachial blood pressure quotient (ankle index), maximal plethysmographic calf blood flow (MPBF) and the activities of PFK, CS, LDH, ACDH and Cyt-ox were measured. 3. SFWD and MWD increased in all three groups. Ankle index and MPBF increased in groups ...
The prevalence of peripheral arterial disease (PAD) is greater than that of HF or stroke (and comparable to the prevalence of MI), affecting approximately 8-12 million Americans. In people with lower-limb PAD, the risk of experiencing a major CV event (ie, MI, stroke, or vascular-related death) is about 5% per year. However, for individuals with critical limb ischemia and the lowest ankle brachial index (ABI), annual mortality soars to approximately 25%. While intermittent claudication is the classic sign of PAD, in fact only 10-15% of people with PAD have the intermittent claudication; about 40% of PAD patients do not complain of leg pain at all, while the remaining 45-50% report a variety of leg symptoms other than classic claudication.. Is the prognosis better in asymptomatic patients? No. As Issam Moussa, MD, explained in a recent review of PAD guidelines presented at AHA 2011, the progression of the underlying PAD is identical whether or not the patient has leg symptoms.. This helps explain ...
Claudication itself is a symptom of a narrowing or blockage of an artery. Pain, a burning feeling, or a tired sensation in the legs and buttocks while walking are symptoms of claudication. In some cases, the sound of blood moving through a blockage (a whooshing sound called a bruit), can be heard through a stethoscope.. The skin of the foot or leg may become shiny, hairless, mottled (blotchy) in appearance, or may ulcerate. The affected leg may become pale when elevated and reddened (rubor) when lowered. Additional symptoms that may be present in persons with claudication include cold feet, impotence in men, and leg pain that occurs at night when in bed. Pain that occurs at rest may be a sign of increasing severity of arterial disease in the leg(s).. The symptoms related to claudication may resemble other medical conditions or problems. Always consult your doctor for a diagnosis.. ...
Claudication itself is a symptom of a narrowing or blockage of an artery. Pain, a burning feeling, or a tired sensation in the legs and buttocks while walking are symptoms of claudication. In some cases, the sound of blood moving through a blockage (a whooshing sound called a bruit), can be heard through a stethoscope.. The skin of the foot or leg may become shiny, hairless, mottled (blotchy) in appearance, or may ulcerate. The affected leg may become pale when elevated and reddened (rubor) when lowered. Additional symptoms that may be present in persons with claudication include cold feet, impotence in men, and leg pain that occurs at night when in bed. Pain that occurs at rest may be a sign of increasing severity of arterial disease in the leg(s).. The symptoms related to claudication may resemble other medical conditions or problems. Always consult your doctor for a diagnosis.. ...
Our results indicate that leg pain is common in PAD patients and can present in atypical ways. In addition, leg pain is not uncommon in patients without definitive PAD, particularly in those with borderline ABI values. These data show that in patients with normal ABIs, pain is still inversely related to the ABI level, at least to an ABI level of 1.40, where arterial stiffness may result in a false-negative ABI.. These data suggest that patients who complain of bilateral leg pain, whether or not it is PAD related, have a very strong tendency to report the same type of pain in both legs. Interestingly, in the 80 patients with unilateral PAD and unilateral pain, the pain was not in the leg with PAD 13.8% of the time. This finding underscores the limitation of claudication questionnaires that do not assess symptoms separately for each leg or limitations in our own understanding of pain-processing pathways.. Taking all patients combined, there was a stepwise decrease in average ABI from no pain, pain ...
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Equally satisfactory rehabilitative outcomes were observed in elderly patients with claudication limited by ODs who completed a well-tolerated, low-impact structured exercise programme.
Claudication is pain and/or cramping in the lower leg due to inadequate blood flow to the muscles. The pain usually causes the person to limp. The word
Peripheral angioplasty is a minimally invasive procedure that is used to remove the blockage or plaque build-up in a vein or artery outside the brain and heart (usually in the legs). It is carried out using an x-ray like machine called an angiogram. A thin tube called a catheter is inserted into the artery or vein and when it reaches the affected area a balloon at the end of the catheter is inflated. This pushes out the plaque build-up and clears the blockage. The balloon is then deflated. Sometimes if the artery or vein is determined to be very weak and if it poses a risk of a collapse, a stent is placed at the site to hold it up and allow regular blood flow.. ...
Peripheral angioplasty Overview, Hardware. Frijo Jose A. Vascular Access. Relatively disease-free, without signi Ca Over a bony structure, if possible Angle of entry- 30⁰-45⁰ If access vessel-small/potentially diseased- micropuncture tech preferred. Vascular Access sites....
Among 442 men and women with PAD, greater 2-year declines in WIQ stair climbing, distance, and speed scores were associated with higher all-cause mortality, after adjusting for baseline ABI, baseline WIQ score, comorbidities, age, and other potential confounders. Participants with ≥20.0 point declines in WIQ stair climbing, WIQ distance, and WIQ speed scores had approximately 2- to 3-fold increases in all-cause mortality compared with those with ≥20.0 point increases in these scores. In addition, participants with a ≥20.0 point decline in WIQ distance score were nearly 4 times more likely to die from CVD compared with those with a ≥20.0 point increase in the WIQ distance score. Because our analyses adjusted for baseline WIQ score, these results demonstrated meaningful associations of change in each WIQ domain score, even after taking into account the baseline WIQ score.. We did not observe a significant association between greater 2-year declines in WIQ stair climbing, distance, and ...
Peripheral vascular disease (PVD) affects 13% of the population aged over 50 in the western world and can be divided into two main groups: organic and functional. Other less common causes to include in the differential diagnosis in younger patients are Buergers disease and anatomical variants such as duplication of the superficial femoral artery and persistent sciatic arteries (PSAs). PVD is a major cause of morbidity and mortality globally. Symptoms vary from cold extremities, intermittent claudication, to acute and critical ischaemia. All of these have a significant financial burden on critical healthcare resources. This case report evaluates the role of ultrasound in the diagnosis of bilateral PSAs. A 16-year-old female was referred by her GP to the vascular clinic presenting with bilateral intermittent claudication. On examination, missing dorsals pedis pulses were noted bilaterally. No previous imaging was available and the patient was referred for a lower limb Doppler ultrasound. Initial ...
Spinal stenosis is a condition causing nerve compression in the spinal canal. It is most commonly caused by degenerative changes (tissue wear and tear). In the case of the lower back, the most typical symptom is pain that radiates from the lower back to the leg, as well as leg numbness and tingling. If the symptoms become worse on walking, the patient may have so-called intermittent claudication. Stopping, sitting down or a hunched position often reduce symptoms. Intermittent claudication may also be due to atherosclerosis (an arterial condition). Spinal stenosis may cause nerve compression symptoms resembling sciatica, but with pain and numbness in a larger area.. If spinal stenosis occurs in the cervical spine (neck), symptoms will include pain that often radiates to the arm, numbness, as well as poorer hand dexterity on one or both sides. Mild symptoms may be treated with NSAID-type painkillers and physiotherapy (link to the page). Further assessments of your back condition are recommended if ...
Neurogenic origin intermittent claudication is typically caused by lumbar spinal canal stenosis. However, there are few reports of intermittent claudication caused by cervical spinal cord compression. We present the case of a 75-year-old woman who presented with intermittent claudication. She had a history of lumbar spinal fusion surgery, but there was no sign of lumbar spinal stenosis. She also reported bilateral thigh pain on cervical extension. Electromyogram (EMG), posture-induced test, myelogram, and post-myelogram dynamic computed tomography (CT) were performed. Myelography and post-myelogram dynamic CT in the cervical extension position showed narrowing of the subarachnoid space; the patient reported pain in the front of the both thigh during the procedure. We performed an electromyogram (EMG), which implied neurogenic changes below the C5 level. Based on these results, we diagnosed cervical spinal cord compression and underwent laminoplasty at C4-6 including dome-like laminectomy, which
TY - JOUR. T1 - Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication. AU - Cooper, Leslie T.. AU - Hiatt, William R.. AU - Creager, Mark A.. AU - Regensteiner, Judith G.. AU - Casscells, Ward. AU - Isner, Jeffrey M.. AU - Cooke, John P.. AU - Hirsch, Alan T.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2001. Y1 - 2001. N2 - Intermittent claudication is the most common symptom of peripheral arterial disease (PAD), in part due to an inadequate rise in limb blood flow with exercise. Claudication causes a severe impairment in functional capacity and quality of life in over 3 million Americans. Basic fibroblast growth factor (bFGF) stimulates angiogenesis in vivo and improves limb blood flow in several animal models of hindlimb ischemia. However, the relative safety and efficacy of angiogenic molecules in the treatment of claudication has not been fully evaluated in prospective, blinded clinical trials. In this study, a ...
Degenerative Lumbar Spinal Stenosis (LSS) is a condition most often observed in people over 60-years-old [1,2]. It is the most common indication for spinal surgery in people older than 65 years [3] and is associated with three main areas of stenosis due to spinal degeneration: Central canal, lateral recess, and intervertebral foramen [4]. The degeneration leads to diminished space around the neural and vascular elements, which can eventually result in symptoms of lower limb Neurogenic Claudication (NC) [4,5]. Neurogenic claudication is a common complaint in people suffering from degenerative LSS that is characterized by lower limb symptoms during standing and walking activities [3]. Common symptoms include unilateral or bilateral leg pain, fatigue, paresthesia, and/or tightness ultimately resulting in impaired ability to stand or walk for prolonged periods of time [5,6]. These symptoms are relieved during sitting and/or in positions of lumbar flexion [4]. These common clinical symptoms are ...
The typical patient with adventitial cystic disease of the popliteal artery is a male in his mid-30s who complains of fairly sudden onset of short-distance calf claudication.11 The duration of symptoms is generally relatively short (weeks to a few months), and except in unusual cases, these symptoms are unilateral.4 Claudication symptoms may completely resolve for a period of time and then recur, or they may pro-gress rapidly. Also, recovery time is often prolonged (20 minutes) compared with that of typical claudicants.20 The differential diagnosis includes popliteal artery entrapment syndrome (discussed later in this chapter), fibromuscular dysplasia, endofibrosis, and premature atherosclerosis. Given the focality of these cysts, the young age of patients, and the otherwise normal status of inflow and outflow vessels, progression to CLI is exceedingly unusual with adventitial cystic disease, although the severity of claudication can progress and become disabling. It appears that the cysts have ...
Trental - Trental is used to improve the symptoms of a certain blood flow problem in the legs/arms (intermittent claudication due to occlusive artery disease).
Trental - Trental is used to improve the symptoms of a certain blood flow problem in the legs/arms (intermittent claudication due to occlusive artery disease).
Evidence-based recommendations on interspinous distraction procedures for lumbar spinal stenosis (LSS) causing neurogenic claudication
Learn more about neurogenic claudication and some of the commonly recommended treatment options with this helpful guide from Laser Spine Institute.
When we tried to ascertain the presence of claudication, the patient reported burning pain in both calves during ongoing and strenuous physical exercise, such as rapid walking for more than 1000 meters, with immediate relief at rest. He first noticed these symptoms when he was about 16 years old, and since then the symptoms have remained constant. He denied the presence of chest pain at rest or on exertion and reported no abdominal symptoms. He started to smoke few cigarettes a day 4 years before presentation. He denied the presence of arterial hypertension, hyperlipidemia, and diabetes. Because of acne-like skin lesion on the neck, a skin biopsy had been performed 14 years earlier. His parents, 4 siblings, wife, and 2 children (2 and 4 years of age) were to his knowledge devoid of any major disease. Physical examination revealed nonpalpable popliteal, posterior tibial, and dorsalis pedis pulses on both sides. Radial and femoral pulses were palpable. No trophic skin changes of the lower limbs ...
TY - JOUR. T1 - A low-cost, wireless near-infrared spectroscopy device detects the presence of lower extremity atherosclerosis as measured by computed tomographic angiography and characterizes walking impairment in peripheral artery disease. AU - Fuglestad, Matthew A.. AU - Hernandez, Hernan. AU - Gao, Yue. AU - Ybay, Henamari. AU - Schieber, Molly N.. AU - Brunette, Katyarina E.. AU - Myers, Sara A.. AU - Casale, George P.. AU - Pipinos, Iraklis I.. PY - 2020/3. Y1 - 2020/3. N2 - Background: Patients with peripheral artery disease (PAD) who experience intermittent claudication report a range of symptoms. Patients with symptoms other than classically described intermittent claudication may be at the highest risk for functional decline and mobility loss. Therefore, technologies allowing for characterization of PAD severity are desirable. Near-infrared spectroscopy (NIRS) allows for measurements of muscle heme oxygen saturation (StO2) during exercise. We hypothesized lower extremities affected by ...
|p||b|OBJECTIVE: |/b|Determining the maximum walking time (MWT) using the treadmill test is the gold standard method for evaluating walking capacity and treatment effect in patients with peripheral arterial disease (PAD). However, self reported functional disability is important when assessing quality of life. Changes in the Walking Estimated Limitation Calculated by History (WELCH) questionnaire scores were compared with the MWT.|/p| |p||b|METHODS: |/b|A cross sectional study was performed in patients with intermittent claudication. The treadmill test (3.2 km/h; 10% gradient) and WELCH questionnaire were administered to all patients for objective evaluation of walking capacity. Given the log normal distribution of these parameters in patients with PAD, a log transformation was applied to the WELCH score (LnW) and maximum walking time (LnT). The responsiveness of the WELCH score was determined using mean changes and correlation coefficients of LnW and LnT changes. The effect of time on the
Claudication consists of symptoms in the legs which are brought on by exertion. With exertion the nerves require more blood and oxygen which they simply cannot get. Some people describe claudication as an aching within the legs, to other people it feels more like numbness. It is sometimes described as though ones legs simply are not doing as they are told and they can become weak and unreliable. For some people, with relatively mild spinal stenosis, claudication will only come on after walking for a long distance or standing for long periods. For other people, it can be very short distances or almost immediately on standing. It is characteristically relieved by resting and so most people will sit down to help their claudication. The main alternative explanation for claudication symptoms in your legs is the lack of blood supply to the muscles themselves in the legs. This can happen if there is a narrowing of the arteries in the legs. If you are investigated for claudication but no spinal ...
In patients with PAD, smoking should be stopped and hypertension, dyslipidemia, and diabetes mellitus treated. Patients with PAD should be treated with atorvastatin 40 mg to 80 mg daily or rosuvastatin 20 to 40 mg daily. ntiplatelet drugs such as aspirin or clopidogrel and angiotensin-converting enzyme inhibitors should be given .Beta blockers should be given if coronary artery disease, especially prior myocardial infarction, s present unless contraindicated. Cilostazol improves exercise time until intermittent claudication. Exercise rehabilitation programs should be used. Indications for lower extremity percutaneous transluminal angioplasty or bypass surgery are 1) incapacitating claudication in patients interfering with work or lifestyle; 2) limb salvage in patientss with limb-threatening ischemia as manifested by rest pain, nonhealing ulcers, and/or infection or gangrene; and 3) vasculogenic impotence. Cite this Article: Aronow WS. Lower Extremity Peripherals Arterial Disease Treatment. SRL ...
Lumbar spinal stenosis can cause classic symptoms of neurogenic claudication but sometimes leg pain, numbness, and weakness are signs of circulatory problems and vascular claudication and are unrelated to narrowing of the spinal canal. Determining the real cause of pain is key to applying proper treatment and achieving pain relief and improved mobility. ...
Eighteen patients with stable intermittent claudication were randomized in a double blind cross-over study comparing the effects of the Ginkgo biloba extract GB-8 at a dose of 120 mg o.d. with placebo. All patients were treated for three months with the active extract and three months with placebo. The effects of treatment on arterial insufficiency were quantified by measurements of systemic and peripheral systolic blood pressures, and pain-free and maximal walking distances on a tread-mill. Questionnaires based on visual analogue scales were used to quantify the severity of leg pain, impairment of concentration, and inability to remember. Short-term memory was objectively assessed. We did not find any significant changes in either peripheral blood pressures, walking distances or the severity of leg pain. Systemic blood pressure was reduced both by placebo and GB-8. The impairment of concentration and the inability to remember were both reduced, when comparing results during active treatment to ...
Vessel imaging in Takayasu arteritis (TAK) is often performed in clinical practice following laboratory test abnormalities or clinical symptoms, such as limb claudication. Conversely, the association between limb claudication and vessel imaging manifestations has not been assessed. This observational, cross-sectional study analyzed 139 adult TAK patients from 2000 to 2018. Their arterial vessel imaging information (especially significant stenosis and occlusion data) was registered and crosschecked with clinical and laboratory data. When vessel imaging was performed, the median age and disease duration of the patients were 38 (27.3-47.0) and 5.0 (1.0-12.0) years, respectively. There was no association between arterial abnormalities and demographic data, constitutional symptoms or laboratory parameters. Limb claudication was reported in 42 patients (30.2%): 17.3% reported it in the upper left limb (ULL), 12.2% reported it in the upper right limb (URL), 12.9% reported it in the lower left limb ...
#DiseaseDetail#Vascular Disease - Overview Peripheral artery disease (also called peripheral arterial disease) is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs. When you develop peripheral artery disease (PAD), your extremities - usually your legs - dont receive enough blood flow to keep up with demand. This causes symptoms, most notably leg pain when walking (claudication). Peripheral artery disease is also likely to be a sign of a more widespread accumulation of fatty deposits in your arteries (atherosclerosis). This condition may be reducing blood flow to your heart and brain, as well as your legs. You often can successfully treat peripheral artery disease by quitting tobacco, exercising and eating a healthy diet. Symptoms While many people with peripheral artery disease have mild or no symptoms, some people have leg pain when walking (claudication). Claudication symptoms include muscle pain or cramping in your legs or arms thats triggered
Disclaimer. The Linus Pauling Institute Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public. The information is made available with the understanding that the author and publisher are not providing medical, psychological, or nutritional counseling services on this site. The information should not be used in place of a consultation with a competent health care or nutrition professional.. The information on dietary factors and supplements, food, and beverages contained on this website does not cover all possible uses, actions, precautions, side effects, and interactions. It is not intended as nutritional or medical advice for individual problems. Liability for individual actions or omissions based upon the contents of this site is expressly disclaimed.. ...
Peripheral artery disease is a narrowing of the arteries in the legs, head, or organs caused by a buildup of plaque. The buildup of plaque reduces blood flow, which can have serious consequences. Some people with peripheral artery disease in their legs have no symptoms. Others have muscle pain or cramping, usually in their lower legs, when they walk or exercise (called intermittent claudication). If the pain is severe, it can be difficult to walk or do other physical activities. This review looks at whether home structured exercise can improve the ability to walk or do other physical activities.. ...
Objectives: Despite available medical therapies, patients with peripheral arterial disease (PAD) remain at high risk for cardiovascular events. n-3 polyunsaturated fatty acids (PUFAs), derived from marine sources, have been shown to improve cardiovascular mortality. The omega-3 index (O3I), a proportion of the n-3 PUFAs eicosapentanoic acid and docosahexanoic acid in the red blood cell membrane, correlates with cardiovascular risk. We sought to determine the clinical factors associated with the O3I in patients with PAD.. Methods: This cross-sectional study included 111 patients, who had an ankle-brachial index of , 0.9 associated with claudication symptoms. We used linear regression to determine the association between demographic and lifestyle factors and the O3I.. Results: The mean age of the cohort was 69 ± 8 years, 37% had diabetes mellitus (Hemoglobin A1c: 7 ± 1%), and 94% had smoked. The mean O3I was 5 ± 2%. Table 1 shows the variables associated with O3I in regression analyses. In a ...
INTRODUCTION Anaemia can compromise muscle and organ function. Related iron and vitamin body stores have seldom been assessed in patients with peripheral arterial disease. REPORT We retrospectively analysed basal prevalence of anaemia, iron, B(12)-vitamin and folic acid deficits in 420 patients with claudication and 204 patients with critical limb ischaemia (CLI). The prevalence of the evaluated parameters was 9.8%, 6.7%, 6.7% and 2.9% among patients with claudication but 49.5%, 31.9%, 15.7% and 6.4% among CLI patients, respectively (p | 0.05 for all). DISCUSSION Anaemia, iron and vitamin deficits are uncommon among patients with ischemic claudication but very prevalent among patients with CLI.
This is a relatively common condition which can result typically in back pain, but mainly leg pains which are brought on and exacerbated by walking a certain distance (claudication distance). The pain is relieved by rest in standing or sitting and the cycle is often repeated following walking similar claudication distance. ...
Peripheral arterial disease has become more and more present in daily practice, mostly due to the increase of cardiovascular risk factors, especially in below the knee (BTK) area in diabetic patients. Critical limb ischemia (CLI) is the most usual clinical presentation with a major amputation rate of 30%, mortality rate of 25%, and chronic pain of 20% at one year. Nowadays, endovascular treatment is usually the first choice, given the high comorbidity of those patients. Angioplasty and stenting in BTK lesions have already proven their efficacy in CLI treatment. However, BTK revascularization remains highly controversial in the treatment of intermittent claudication in TASC 2 recommendations. Restenosis being the major pitfall in BTK procedures, the use of drug-coated devices is one of the actual answers. We performed an extensive review of the literature over the last 15 years on the use of drug-eluting stents (DES) in BTK revascularization. DES has been compared to balloon angioplasty, in the ...
TY - JOUR. T1 - Step-monitored home exercise improves ambulation, vascular function, and inflammation in symptomatic patients with peripheral artery disease. T2 - A randomized controlled trial. AU - Gardner, Andrew W.. AU - Parker, Donald E.. AU - Montgomery, Polly S.. AU - Blevins, Steve M.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Background-This prospective, randomized, controlled clinical trial compared changes in primary outcome measures of claudication onset time (COT) and peak walking time (PWT), and secondary outcomes of submaximal exercise performance, daily ambulatory activity, vascular function, inflammation, and calf muscle hemoglobin oxygen saturation (StO2) in patients with symptomatic peripheral artery disease (PAD) following new exercise training using a step watch (NEXT Step) home-exercise program, a supervised exercise program, and an attention-control group. Methods and Results-One hundred eighty patients were randomized. The NEXT Step program and the supervised exercise program ...
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Cadila Pharmaceuticals Ltd. is an industry leader in synthesizing APIs. We are bulk drug manufacturer of Cilostazol. The CAS number of Cilostazol is 73963-72-1.. Cilostazol is used in the alleviation of the symptoms of intermittent claudication in individuals with peripheral vascular disease. Cilostazol is a phosphodiesterase inhibitor with therapeutic focused on cAMP. It inhibits platelet aggregation and it is a direct arterial vasodilator. Its major effects are dilation of the arteries supplying blood to the legs and decreasing platelet coagulation.. Cadila Pharmaceuticals Ltd. is one of the USFDA approved pharma contract manufacturing companies in India. It is known as one of the top Active Pharmaceutical Ingredients (APIs) manufacturing company based in India. We synthesize APIs of the superb quality in cost-effective manner.. We are major Cilostazol manufacturer and supplier. We supply peripheral vascular disease drug Cilostazol to domestic market and country like Japan.. ...
At a symposium on the diabetic foot, Christopher J. Kwolek (Boston, MA) discussed endovascular treatment of peripheral vascular disease (PVD), suggesting that this may be appropriate for treatment at earlier stages in the spectrum of disease proceeding from claudication to rest pain and from ulcer to gangrene. The term claudication, he noted, derives from the Latin root for limping or lameness and describes a syndrome of weakness or onset of pain after walking is begun. Claudication can be relieved after a period of rest and may occur during the night because gravity may increase perfusion when upright. Patients with PVD have a high 10-year mortality (48% for those with claudication, 80% for those with rest pain, and 95% for those with gangrene). Signs of peripheral ischemia include absent pulses, blanching on elevation, dependent rubor, delayed venous filling, shiny atrophic skin, loss of hair on lower extremities, and, ultimately, atrophy of the subcutaneous tissues and progression to ...
Peripheral artery disease (PAD) is very common, mainly in people over age 50. PAD is caused by narrowed or blocked arteries in the legs or in the bodys main artery (the aorta). This can reduce blood flow to muscles in your calf, thigh, or buttocks. This decreased blood flow may cause the pain that leads to claudication.. The blockage usually happens because of narrowed and hardened arteries (atherosclerosis). This is caused by plaque build-up inside the arteries. Plaque is made up of fat, cholesterol, calcium, and other substances in the blood. This plaque build-up can also affect your heart arteries. It can lead to chest pain or a heart attack.. Blockages in the leg are most common in the thigh and behind the knee. But they can also occur in other parts of the body such as the aorta, groin, or belly. You can have more than 1 blockage.. ...
article{645ecd8f-deca-4f92-8ead-33f2083d54ce, abstract = {Background: In Malmo approximately 250 000 citizens live in 17 administrative areas with substantial socioeconomic differences. At the single centre for arterial reconstruction, Malmo University Hospital, all procedures are registered prospectively. Methods: Between 1987 and 2002, 1832 Malmo citizens underwent reconstruction for peripheral arterial disease, either intermittent claudication (IQ or critical leg ischaemia (CLI). A socioeconomic score based on migration rate, percentage of residents with foreign citizenship/residents with foreign background, social welfare support dependency and unemployment rate has previously been developed and validated for each area. The relationship between socioeconomic score and area-specific standardized morbidity ratios (SMRs) after vascular reconstruction was analysed by population-weighted linear regression. Results: The mean incidence of vascular reconstruction was 76 (range 27-106) per 100000 ...
see Swiss spinal stenosis score Synonyms Zurich Claudication Questionnaire, Brigham Spinal Stenosis Questionnaire, Swiss Spinal Stenosis Scoring, Swiss Spinal Stenosis Score, Swiss Spinal Stenosis Measure.
The Medicines and Healthcare products Regulatory Agency (MHRA) has published Drug Safety Update for April 2013 (PDF).. This issue contains drug safety advice informing clinicians of the potential risk of error with insulin degludec (Tresiba®) due to it being available in two strengths. Clinicians are urged to ensure that the correct insulin product and strength is prescribed and pharmacists should check again when the product is dispensed. It is also advised that patients are trained on how to use the device in particular they should always visually verify the dialled units on the dose counter.. This section also warns of the risk of cardiovascular and bleeding events associated with use of cilostazol (Pletal®). This drug is licensed for use to improve walking distances in patients with intermittent claudication. A recent safety review has concluded that the benefits of treatment are worthwhile in some, but not all patients. It is recommended that cilostazol is now used as second line ...
Atherosclerosis remains the major cause of death and premature disability in developed societies. Moreover, current predictions estimate that by the year 2020 cardiovascular diseases, notably atherosclerosis, will become the leading global cause of total disease burden. Although many generalized or systemic risk factors predispose to its development, atherosclerosis affects various regions of the circulation preferentially and has distinct clinical manifestations that depend on the particular circulatory bed affected. Atherosclerosis of the coronary arteries commonly causes myocardial infarction (MI) (Chap. 295) and angina pectoris (Chap. 293). Atherosclerosis of the arteries supplying the central nervous system frequently provokes strokes and transient cerebral ischemia (Chap. 446). In the peripheral circulation, atherosclerosis causes intermittent claudication and gangrene and can jeopardize limb viability. Involvement of the splanchnic circulation can cause mesenteric ischemia. ...
where to buy trental peripheral vascular disease, intermittent claudication, chronic occlusive arterial disease in internet store without script Alaska ...
OBJECTIVE: To describe mortality and morbidity during a period of 2 years after coronary artery bypass grafting (CABG) in relation to a history of hypertension. PATIENTS: All patients in western Sweden in whom CABG was undertaken between June 1988 and June 1991 and in whom simultaneous valve surgery was not performed were included in the study. DESIGN: A prospective 2-year follow-up study. RESULTS: Patients with a history of hypertension (n = 777) differed from patients without such a history (n = 1348) in that the proportion of women was higher, they were older and more frequently had a history of congestive heart failure, diabetes mellitus, renal dysfunction, cerebro-vascular disease, intermittent claudication and obesity, and the number of smokers and patients with previous CABG was lower. They were also more likely to develop post-operative cerebrovascular complications and signs of myocardia damage. Patients with hypertension tended to have increased mortality during the first 30 days after ...
Buy Trental Online! Generic Trental is used for treating intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) in certain patients. It may also be used for other conditions.
Buy Trental Online! Generic Trental is used for treating intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) in certain patients. It may also be used for other conditions.
Buy Trental Online! Generic Trental is used for treating intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) in certain patients. It may also be used for other conditions.
An Iraqi patient came with intermittent claudication and inability to walk more than 100 meter of stand for 5 min with bilateral drop feet for several months. MRI done (bad quality) showing complete stenosis at L4-5. The patient underwent complete laminectomy L4 with bilateral L5 foraminotomy. Despite the roots were free, but remained stretched over the moderately bulge and mobile disc L4-5. Considering these facts, discectomy L4-5 with bilateral cleaning was done to achieve total decompression of the L5 roots ...
Angiogenesis refers to the generation of new blood vessels from preexisting blood vessels, a process which accompanies a wide variety of pathological states including cancer, wound healing, atherosclerosis and inflammatory disease. Angiogenesis is induced by cytokines and growth factors such as those of the VEGF family, FGF-2, PDGF-B, TGF- b, Ang-1, Ang-2, etc. However, inhibitors such as the thrombospondins are equally important in modulation of this response. Angiogenesis has now become a major field of investigation as many laboratories around the world are attempting to enhance the growth of new blood vessels (as in ischemic heart disease and intermittent claudication) and to prevent vessel growth or even to destroy preexisting vessels that have been induced by cancer.
Guide Wires, Microcatheters Peripheral Angioplasty Balloon s Peripheral Stents Intravascular Lithotripsy (IVL) System M AGICTOUCH AVF - Sirolimus Coated Balloon in Dysfunctional
Treatment options for PAD vary from lifestyle modification for mild claudication to bypass surgery for limb-threatening problems such as gangrene or pain that occurs without any exertion (pain at rest.) The large majority of patients can be treated without invasive therapy-lifestyle modification, lipid (cholesterol) management and exercise. However, there are some patients whose claudication will not improve with even the strictest adherence to these recommendations. Many of these patients are younger and are not willing to resort to a lifestyle limited by their PAD.. Our success with those patients has been remarkable and quite gratifying. While these patients are not in danger of losing their legs, their PAD has adversely affected their lives. They can no longer do the activities-social, physical or personal-that they were able to do just several years ago. The cramping pain in their calves or thighs limits them in their lifestyle. Walking the boardwalk or chasing their young grandchildren is ...
About Spectranetics. The Spectranetics Corporation develops, manufactures, markets and distributes medical devices used in minimally invasive procedures within the cardiovascular system. The Companys products are available in over 65 countries and are used to treat arterial blockages in the heart and legs and in the removal of pacemaker and defibrillator leads.. The Companys Vascular Intervention (VI) products include a range of laser catheters for ablation of blockages in arteries above and below the knee, the AngioSculpt scoring balloon used in both peripheral and coronary procedures, and the Stellarex drug-coated balloon peripheral angioplasty platform, which received European CE mark approval in December 2014. The Company also markets support catheters to facilitate crossing of peripheral and coronary arterial blockages, and retrograde access and guidewire retrieval devices used in the treatment of peripheral arterial blockages, including chronic total occlusions. The Company markets ...
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Is this correct: 36245, 37220, 75716-26? Thank You! REASON FOR EVALUATION: Claudication. HISTORY OF THE PRESENT ILLNESS: This patient is well-known to
In a Cochrane systematic review on the use of pentoxifylline for intermittent claudication in 2015, the following was concluded ... Given all these factors, the role of pentoxifylline in intermittent claudication remains uncertain, although this medication ... or weakness in the arms or legs which occurs due to intermittent claudication, a form of muscle pain resulting from peripheral ... a PDE-3 inhibitor with better evidence for intermittent claudication on the Cochrane review cited above. Drugs.com drugs.com ...
... intermittent claudication after walking a distance of more than 200 meters Stage IIb: intermittent claudication after walking a ... mild claudication Grade I, Category 2: moderate claudication Grade I, Category 3: severe claudication Grade II, Category 4: ... High blood pressure increases the risk of intermittent claudication, the most common symptom of PAD, by 2.5- to 4-fold in men ... Of patients with intermittent claudication, only "7% will undergo lower-extremity bypass surgery, 4% major amputations, and 16 ...
... mainly in symptoms related to intermittent claudication, ulcer healing and others. At least a couple of uses for this agent ... "Nicotinyl Alcohol Tartrate in Intermittent Claudication". British Medical Journal. 18 (2): 207-208. PMID 1974214. Fisher MM, ...
Severe vasoconstriction may cause symptoms of intermittent claudication. Ergotamine interacts with serotonin, adrenergic, and ...
Peripheral vascular examination Intermittent claudication Al-Qaisi, M; Nott, DM; King, DH; Kaddoura, S (2009). "Ankle brachial ...
Cilostazol is used for the treatment of intermittent claudication. This drug has a much weaker positive inotropic effect than ...
Severe vasoconstriction may result in symptoms of intermittent claudication. The mechanism that leads to vasoconstriction ...
Cerebrovascular disease, stroke and transient ischemic attack (TIA). Peripheral arterial disease, intermittent claudication and ...
Also: Raynaud's syndrome, intermittent claudication, epilepsy, depression, Parkinson's disease, glaucoma. Use in pregnancy is ... Noteworthy side effects include dry mouth, headache, fatigue, dizziness, intermittent facial oedema, nausea, sleep disturbances ...
Anagrelide Cilostazol is used in the treatment of intermittent claudication. Pimobendan is FDA approved for veterinary use in ...
Imaging of spinal stenosis: neurogenic intermittent claudication and cervical spondylotic myelopathy. Radiol Clin North Am. ...
"The history of intermittent claudication due to arterial disease" (in French). Elsevier Masson. Media related to Henri Bouley ...
"Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication". JoVE (Journal ...
Djoussé L, Levy D, Murabito JM, Cupples LA, Ellison RC (2000). "Alcohol consumption and risk of intermittent claudication in ... A study found that moderate consumption of alcohol had a protective effect against intermittent claudication. The lowest risk ...
"Ginkgo biloba for intermittent claudication". Cochrane Database of Systematic Reviews (Systematic review). 6 (6): CD006888. doi ...
Rationale and design for PACE: patients with intermittent claudication injected with ALDH bright cells. Am Heart J. 2014 Nov; ... Patients With Intermittent Claudication Injected With ALDH Bright Cells). Circulation. 2017 Apr 11;135(15):1417-1428. doi: ...
... is also licensed for the treatment of intermittent claudication due to peripheral arterial disease. Naftidrofuryl ...
The pathophysiology is similar to that seen in angina pectoris and intermittent claudication. The most common cause of ... Stedman's Medical Dictionary Online defines abdominal angina as "intermittent abdominal pain, frequently occurring at a fixed ...
Fowkes, FG; Gillespie, IN (2000). "Angioplasty (versus non surgical management) for intermittent claudication". The Cochrane ...
In this way, stable angina may be thought of as being similar to intermittent claudication symptoms. Other recognized ...
They have cold legs and feet or have pain in their legs with exercise (intermittent claudication).[citation needed] In cases of ...
"Safety, Efficacy, and Pharmacokinetics (PK) Study of Trans Sodium Crocetinate (TSC) in Patients With Intermittent Claudication ...
... is approved for the treatment of intermittent claudication in the United States and United Kingdom. Cilostazol is ... is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. If no improvement is ... FDA concluded that fully informed patients and physicians should be able to choose to use it to treat intermittent claudication ...
It is more severe than intermittent claudication, which is also a pain in the legs from arterial insufficiency.[citation needed ... Compared to the other manifestation of PAD, intermittent claudication, CLI has a negative prognosis within a year after the ...
2012). "Results for primary bypass versus primary angioplasty/stent for intermittent claudication due to superficial femoral ... 2011). "Trends in the national outcomes and costs for claudication and limb threatening ischemia: angioplasty vs bypass graft ...
... position statement on exercise prescription for patients with peripheral arterial disease and intermittent claudication". ...
... sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and intermittent claudication ...
... thin and pale with little exercise tolerance due to intermittent claudication. A series of X-rays were reviewed which, reported ...
This is useful in conditions such as intermittent claudication, as the cells can maneuver through constricted veins and ...
"intermittent claudication" at Dorland's Medical Dictionary *^ Dr Hicks, Rob. "Intermittent Claudication". BBC Health.. .mw- ... Intermittent claudication (Latin: claudicatio intermittens), also known as vascular claudication, is a symptom that describes ... of the Western population older than 65 years and for intermittent claudication this number is around 5%. Intermittent ... Intermittent claudication is a symptom and is by definition diagnosed by a patient reporting a history of leg pain with walking ...
... intermittent claudication) and problems due to a decreased blood supply to the feet (such as gangrene).[4] Atherosclerosis risk ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ... The symptoms of vertebral artery dissection include head and neck pain and intermittent or permanent stroke symptoms such as ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Severe vasoconstriction may result in symptoms of intermittent claudication.[1]. Contents. General mechanismEdit. The mechanism ...
"Alcohol consumption and risk of intermittent claudication in the Framingham Heart Study". Circulation 102 (25): 3092-7. PMID ... White AM, Bae JG, Truesdale MC, Ahmad S, Wilson WA, Swartzwelder HS (Julai 2002). "Chronic-intermittent ethanol exposure during ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Intermittent claudication. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic. *Cholesterol. *LDL. * ...
Atherosclerosis - Aortic dissection - Raynaud's phenomenon/Raynaud's disease - Buerger's disease - Intermittent claudication - ...
Intermittent claudication. *Spasm of artery. *(I74) Arterial embolism and thrombosis. *(I77) Other disorders of arteries and ...
Atherosclerosis - Aortic dissection - Raynaud's phenomenon/Raynaud's disease - Buerger's disease - Intermittent claudication - ...
Kannel W, McGee D «Update on some epidemiologic features of intermittent claudication: the Framingham Study». Journal of the ... Smith GD, Shipley M, Rose G «Intermittent claudication, heart disease risk factors, and mortality. The Whitehall Study.». ... Fowkes FG, Gillespie IN «Angioplasty (versus non surgical management) for intermittent claudication». Cochrane Database Syst ...
... intermittent claudication of the legs, and symptoms of heart failure. On examination, the signs exhibited may include pallor ( ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ... Intermittent pneumatic compression devices may be used, but it is not clear that they are superior to simple compression ... Nelson EA, Hillman A, Thomas K (2014). "Intermittent pneumatic compression for treating venous leg ulcers". Cochrane Database ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
Peripheral vascular disease, which contributes to intermittent claudication (exertion-related leg and foot pain) as well as ...
Intermittent explosive disorder(英语:Intermittent explosive disorder). *Psychomotor agitation(英语:Psychomotor agitation) ...
Intermittent claudication. *Critical limb ischemia. *Monckeberg's arteriosclerosis. *Arteriolosclerosis *Hyaline. *Hyperplastic ...
In the circulatory system, intermittent claudication (leg pain during walking which resolves at rest) is a prominent feature, ...
Stenosis of renal artery 440.2 Peripheral Arterial Disease 440.21 Peripheral Arterial Disease with Intermittent Claudication ( ... Also Claudication) 440.23 Peripheral Arterial Disease w/ ulceration 441 Aortic aneurysm and dissection 441.0 Aortic Dissection ...
"intermittent claudication" at Dorlands Medical Dictionary *^ Dr Hicks, Rob. "Intermittent Claudication". BBC Health.. .mw- ... Intermittent claudication (Latin: claudicatio intermittens), also known as vascular claudication, is a symptom that describes ... of the Western population older than 65 years and for intermittent claudication this number is around 5%. Intermittent ... Intermittent claudication is a symptom and is by definition diagnosed by a patient reporting a history of leg pain with walking ...
Is this really intermittent claudication?. Ask about key symptoms of peripheral arterial disease, including walking distance ... Intermittent claudication. BMJ 2007; 334 doi: https://doi.org/10.1136/bmj.39036.624306.68 (Published 05 April 2007) Cite this ... Spinal claudication manifests as weakness not pain and starts soon after standing up, with relief on sitting or bending (lumbar ...
The pain is intermittent and goes away when the person rests. ... intermittent claudication (inter-mit-ĕnt) n. see claudication. ... Intermittent Claudication Definition Intermittent claudicationis a pain in the leg that a person experiences when walking or ... Intermittent Claudication. Definition. Intermittent claudicationis a pain in the leg that a person experiences when walking or ... Walking is frequently an important treatment for intermittent claudication. A person experiencing the pain of intermittent ...
Intensive intermittent claudication - Pain in the muscles of the leg that occurs off and on, usually while walking or ... exercising, and results in lameness (claudication). The pain results from a narrowing of the blood vessels feeding the muscle. ... Medical Word - Intensive intermittent claudication. Ans : Pain in the muscles of the leg that occurs off and on, usually while ... Intensive intermittent claudication - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia ...
How well does pentoxifylline treat intermittent claudication?. *Omega-3 fatty acid supplementation for intermittent ... Naftidrofuryl for intermittent claudication. Your browser does not support the audio element. ... de Backer TLM, Vander Stichele R, Lehert P, Van Bortel L. Naftidrofuryl for intermittent claudication. Cochrane Database of ... Lifestyle changes and cardiovascular prevention measures are a primary treatment for intermittent claudication (IC). ...
Anticoagulants for intermittent claudication. Atherosclerosis is a disease of the arteries in which fatty deposits block the ... This can cause intermittent claudication, when cramping pain in the legs is brought on by exercise and relieved by rest. These ... There is no clear evidence to support the use of anticoagulants for intermittent claudication at this stage. More research is ... The benefit of heparin, LMWHs and oral anticoagulants for treatment of intermittent claudication has not been established while ...
Intermittent Claudication. Pathological Conditions, Anatomical. Spinal Diseases. Bone Diseases. Musculoskeletal Diseases. ... System Versus Standalone Decompressive Surgery in Degenerative Lumbar Spinal Stenosis With Neurogenic Intermittent Claudication ... System Versus Standalone Decompressive Surgery in Degenerative Lumbar Spinal Stenosis with Neurogenic Intermittent Claudication ... Mean Percentage Change From Baseline in Physical Function at 1 Year Follow-up Using the Patient Completed Zurich Claudication ...
Intermittent symptoms are ones that come and go at irregular and unpredictable intervals; learn how to get meaningful relief ... Intermittent neurogenic claudication Sections *Neurogenic Claudication *Neurogenic Claudication Overview *What is Neurogenic ... Symptoms of intermittent neurogenic claudication can often be traced to compression of the spinal cord or nerve root(s) in the ... Intermittent neurogenic claudication is a collection of symptoms usually caused by lumbar spinal stenosis - or narrowing of the ...
Tag Archives: intermittent claudication. ASH Research Report: Smoking and Peripheral Arterial Disease. This research report ... Tags: Abdominal aortic aneurysm, Buergers disease, circulatory disease, intermittent claudication, peripheral arterial disease ...
Prostaglandin E1 in Outpatients With Intermittent Claudication. The safety and scientific validity of this study is the ... Intermittent Claudication Fontaine Stage II PAOD. Interventions Drug: Alprostadil (Prostaglandin E1). Drug: Pentoxifylline. ...
... intermittent claudication, joint pain including Systemic Lupus Erythematosus (SLE) ...
... walking or exercising but the pain gradually disappears as soon as you rest you probably suffer from intermittent claudication ... What is Intermittent Claudication?If one, or less commonly, both of your legs are aching while you are ... What is Intermittent Claudication?. If one, or less commonly, both of your legs are aching while you are walking or exercising ... Intermittent Claudication is a clinical sign of peripheral arterial disease. Find out more about the causes, risk factors and ...
Search terms included exercise, intermittent claudication and muscle. Studies about IC which were focused on muscle histology, ... Despite awareness about the impact of intermittent claudication (IC) on mobility, balance and quality of life; the underlying ... Review of the adaptation of skeletal muscle in intermittent claudication () Risha Gohil, Tristan Robert Alexander Lane, Patrick ... Alpert, J.S., Larsen, O.A. and Lassen, N.A. (1969) Exercise and intermittent claudication. Blood flow in the calf muscle during ...
Intermittent Claudication / blood, complications, physiopathology*. Leg / blood supply. Male. Myocardial Infarction / etiology ... This included 18 patients with mild intermittent claudication (MC, pain-free walking distance , or = 200 meters) and 51 ... patients with severe claudication (SC, walking distance ,200 meters). Eleven age- and sex-matched patients without PAD served ... well as a significant inverse correlation between tPA antigen levels and pain-free walking time in patients with claudication ( ...
... describes a set of debilitating symptoms most often associated with lumbar central spinal ... Neurogenic Intermittent Claudication Treatment. Treatment for neurogenic intermittent claudication usually centers on resolving ... Causes of Neurogenic Intermittent Claudication. The most commonly diagnosed cause of neurogenic claudication is certainly ... Neurogenic intermittent claudication describes a set of debilitating symptoms most often associated with lumbar central spinal ...
... included a self-administered version of the London School of Hygiene questionnaire on chest pain and intermittent claudication ... Self-administration of a questionnaire on chest pain and intermittent claudication Br J Prev Soc Med. 1977 Mar;31(1):42-8. doi ... included a self-administered version of the London School of Hygiene questionnaire on chest pain and intermittent claudication ...
Pentoxifylline for Intermittent Claudication. Ernst, E. // Angiology;May1994, Vol. 45 Issue 5, p339 Pentoxifylline was first ... THERAPY IN INTERMITTENT CLAUDICATION. Pomeranze, Julius; Gadek, Rymond J.; Pitman, Ernest R.; Scherl, Siegfried // Angiology; ... Treatment of intermittent claudication. Karthikeyan, G.; Eikelboom, John W. // BMJ: British Medical Journal (Overseas & Retired ... The authors reflect on methods which are used to treat intermittent claudication. They suggest that any methods that are used ...
Intermittent Claudication in a 28-Year-Old Man With Pseudoxanthoma Elasticum. Olga von Beckerath, Jochen Gaa, Christoph Winkler ... Intermittent Claudication in a 28-Year-Old Man With Pseudoxanthoma Elasticum. Olga von Beckerath, Jochen Gaa, Christoph Winkler ... Intermittent Claudication in a 28-Year-Old Man With Pseudoxanthoma Elasticum. Olga von Beckerath, Jochen Gaa, Christoph Winkler ... When we tried to ascertain the presence of claudication, the patient reported burning pain in both calves during ongoing and ...
Intermittent Claudication / blood*. Leukocyte Count. Male. Middle Aged. Neutrophil Activation / physiology*. Neutrophils. ... 9717887 - Prediction of peak oxygen consumption in patients with intermittent claudication.. 10843347 - Determinants of peak v( ... The antioxidant activity of glutathione peroxidase is reduced in patients with claudication and may allow the unopposed action ... In patients with claudication, the level of von Willebrands factor increased to 150 (140-156) units dl-1 60 min after exercise ...
Learn more about Intermittent Claudication at Grand Strand Medical Center Related Terms: Peripheral Vascular Disease Uses ... This condition is called intermittent claudication. The intensity of intermittent claudication is often measured in the ... symptoms of intermittent claudication. 32 Various antioxidants have been suggested for the treatment of intermittent ... A number of natural treatments may be helpful for intermittent claudication, but it isnt clear whether it is safe to combine ...
The pain of intermittent claudication has three characteristics:
  • It is a cramping pain in the calves that is brought ... Intermittent claudication is a predictable pattern of lower leg pain caused by inadequate blood flow to exercising muscle.### ... Risk factors for Intermittent Claudication:. Circulation. Atherosclerosis Hypertension Buergers Disease The initial symptoms ... Claudication: Often Intermittent claudication: Condition caused by interruptions of blood supply to the muscles, characterized ...
For references and more information, see the section on intermittent claudication and PAD in L-carnitine article. ... The activity-induced muscle pain associated with PAD is clinically termed intermittent claudication. Left untreated, PAD can ... See below for specific information about nutrients and dietary factors relevant to intermittent claudication. ... Claudication - pain caused by insufficient blood flow during exercise Periphery - the outer regions of the body; away from the ...
Pentoxifylline and Intermittent Claudication Annals of Internal Medicine; 102 (1): 126-127 ... Conservative Management of Intermittent Claudication. Ann Intern Med. 1990;113:135-146. doi: 10.7326/0003-4819-113-2-135 ... Ramipril improved walking times and QOL in peripheral artery disease and intermittent claudication Annals of Internal Medicine; ... Ramipril improved walking times and QOL in peripheral artery disease and intermittent claudication Annals of Internal Medicine; ...
What are the SVS guidelines for surgical treatment of intermittent claudication (IC) in peripheral arterial occlusive disease ( ... Drug therapy for improving walking distance in intermittent claudication: a systematic review and meta-analysis of robust ... A Review of the Potential Local Mechanisms by Which Exercise Improves Functional Outcomes in Intermittent Claudication. Ann ... Medical management of claudication. J Vasc Surg. 2017 Jul. 66 (1):275-280. [Medline]. ...
Intermittent Claudication is caused by narrowing or blockage in the main artery taking blood to your leg (femoral artery). Read ... Intermittent Claudication is caused by narrowing or blockage in the main artery taking blood to your leg (femoral artery). This ... Very few patients with intermittent claudication will ever be at risk of losing a leg through gangrene. It is the vascular ... Claudication is not usually limb threatening and it is not necessary to treat it if the symptoms are mild. Claudication often ...
Recommendations for medical treatment of intermittent claudication (IC) include the following: Multidisciplinary comprehensive ... Recommendations for medical treatment of intermittent claudication (IC) include the following:. * Multidisciplinary ... What are the SVS guidelines for the medical treatment of intermittent claudication (IC) in peripheral arterial occlusive ... Drug therapy for improving walking distance in intermittent claudication: a systematic review and meta-analysis of robust ...
Intermittent Claudication. Intermittent claudication is a predictable pattern of lower leg pain caused by inadequate blood flow ... Claudication. Often Intermittent claudication: Condition caused by interruptions of blood supply to the muscles, characterized ... The pain of intermittent claudication has three characteristics:. *It is a cramping pain in the calves that is brought on by ... Intermittent claudication is caused by arterial insufficiency (inadequate blood supply), primarily due to atherosclerosis. ...
Insidious onset of intermittent claudication as the primary manifestation of infective endocarditis George Vasquez-Rios,1,2 ... Insidious onset of intermittent claudication as the primary manifestation of infective endocarditis. ...
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  • Most commonly, intermittent (or vascular or arterial) claudication is due to peripheral arterial disease which implies significant atherosclerotic blockages resulting in arterial insufficiency. (wikipedia.org)
  • However, as other conditions such as sciatica can mimic intermittent claudication, testing is often performed to confirm the diagnosis of peripheral artery disease . (wikipedia.org)
  • Magnetic resonance angiography and duplex ultrasonography appear to be slightly more cost-effective in diagnosing peripheral artery disease among people with intermittent claudication than projectional angiography . (wikipedia.org)
  • Intermittent claudication is the main symptom of peripheral arterial disease (PAD), which is also known as peripheral vascular disease, and or occlusive arterial disease. (encyclopedia.com)
  • Intermittent claudication is an early symptom of the condition that affects peripheral arteries, those blood vessels located outside the heart. (encyclopedia.com)
  • Peripheral artery disease "intermittent claudication" at Dorland's Medical Dictionary Dr Hicks, Rob. (wikipedia.org)
  • Intermittent claudication is a symptom of peripheral arterial disease. (biotronik.com)
  • Intermittent Claudication is a clinical sign of peripheral arterial disease. (biotronik.com)
  • What are the SVS guidelines for surgical treatment of intermittent claudication (IC) in peripheral arterial occlusive disease (PAOD)? (medscape.com)
  • The most common symptom of peripheral arterial disease is intermittent claudication (Fontaine stage II), which is characterised by pain in the legs or buttocks that occurs with exercise and is relieved with rest. (nice.org.uk)
  • People with peripheral arterial disease, and specifically with intermittent claudication, are at increased risk of myocardial infarction and stroke. (nice.org.uk)
  • Additionally, people with intermittent claudication are at higher risk from cardiovascular mortality than people with asymptomatic peripheral arterial disease. (nice.org.uk)
  • 4.1.1 The Assessment Group conducted a systematic review of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate within their licensed indications for the treatment of intermittent claudication in people with peripheral arterial disease whose symptoms continue despite conventional management. (nice.org.uk)
  • We recently reported that ramipril more than doubled walking times in peripheral artery disease patients with intermittent claudication. (ahajournals.org)
  • Presence of numerous diet responsive comorbidities and high atherosclerotic burden among adults with intermittent claudication demands attention is given to diet in an effort to delay progression of peripheral artery disease. (biomedcentral.com)
  • Despite evidence to support benefits of dietary modification in risk reduction of peripheral artery disease, adults with intermittent claudication continue to consume poor diets. (biomedcentral.com)
  • Claudication or intermittent claudication and peripheral artery disease should be treated immediately to prevent it to get worse. (epainassist.com)
  • In serious conditions of claudication or intermittent claudication and peripheral artery disease, angioplasty is prescribed by the doctor. (epainassist.com)
  • A healthy lifestyle is an alternate to survive from the claudication or peripheral artery disease. (epainassist.com)
  • Methods: The study comprised 39 patients with peripheral arterial disease limited by intermittent claudication. (elsevier.com)
  • Several medical problems can cause claudication, but the most common is peripheral artery disease (PAD). (healthncare.info)
  • Treatment of claudication and peripheral artery disease can help prevent your disease from getting worse and reduce your symptoms. (healthncare.info)
  • The most common cause of intermittent claudication is peripheral artery disease or PAD. (healthandfitnesstalk.com)
  • Arthritis and spinal stenosis as well as peripheral neuropathy can also cause intermittent claudication. (healthandfitnesstalk.com)
  • The most common cause of intermittent claudication is peripheral arterial disease, which is when plaques of fatty acids, platelets, calcium, and other substances build up in the arteries in your legs (this process is called atherosclerosis), narrowing them, and restricting blood flow. (medicine.com)
  • This study suggests that hydration attained by daily water consumption of more than 2.5 L has a robust impact in reducing the symptoms of disabling claudication and rest pain caused by peripheral vascular disease. (podiatryarena.com)
  • A natural compensation for PAD-related vascular occlusions and resultant claudication is expansion of preexisting arterial pathways, known as collateral arteries, which bypass an occlusion and provide increased blood flow to peripheral tissues, especially during periods of increased metabolic demand. (lermagazine.com)
  • Claudication or intermittent claudication is the pain, fatigue, cramping or tightness you feel in your calf as a result of your peripheral artery disease. (wakemed.org)
  • To assess safety and efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in patients with peripheral artery disease (PAD) and to explore associated claudication physiologic mechanisms. (nih.gov)
  • Using Large Scale Data Analytics to Identify Health Care Trends Overview Intermittent Claudication is the most common symptomatic presentation of peripheral arterial disease in the lower extremities. (bu.edu)
  • Intermittent claudication - a symptom inherent in peripheral arterial disease of lower extremities, such as atherosclerosis. (ucoz.com)
  • Intermittent claudication is one of the earliest signs of peripheral arterial disease. (ucoz.com)
  • As mentioned above, intermittent claudication - a sign of peripheral arterial disease of lower extremities, such as atherosclerosis and occlusive disease. (ucoz.com)
  • Intermittent claudication, according to the Fontaine classification, is a classical symptom of stage II peripheral arterial occlusive disease (PAOD) of the lower limbs. (viamedica.pl)
  • Alternative exercise modes, such as cycling, strength training and upper-arm ergometry compared to supervised walking programmes showed no difference in maximum walking distance or pain-free walking distance for people with intermittent claudication. (wikipedia.org)
  • Oral naftidrofuryl has a statistically significant and clinically meaningful, although moderate, effect of improving walking distance in the six months after initiation of therapy for people with intermittent claudication. (cochrane.org)
  • Most people with intermittent claudication never develop serious problems with their leg. (veins.wales)
  • Many people with intermittent claudication are smokers, and giving up smoking is very important. (veins.wales)
  • Most people with intermittent claudication describe the pain as an aching deep in the muscle that worsens the longer they exercise. (healthandfitnesstalk.com)
  • But because the arteries in people with intermittent claudication are obstructed, not enough blood can reach the muscles. (medicine.com)
  • Double-blind studies involving a total of about 400 individuals have found that it can improve walking distance for people with intermittent claudication. (epnet.com)
  • The authors reflect on methods which are used to treat intermittent claudication. (ebscohost.com)
  • How would you treat intermittent claudication? (healthtap.com)
  • How do physicians treat intermittent claudication of both legs? (healthtap.com)
  • How to treat intermittent claudication of both legs? (healthtap.com)
  • Walking and exercising can help prevent and treat intermittent claudication, as they enhance the circulation of blood. (hypervibe.com)
  • However, the only pharmaceutical agents currently approved by the US Food and Drug Administration to treat intermittent claudication are the phosphodiesterase inhibitors pentoxifylline and cilostazol, 8 and these drugs have been shown to provide only minimal improvement for claudicants in terms of maximal treadmill walking distance. (lermagazine.com)
  • [ clarification needed ] It is distinct from neurogenic claudication , which is associated with lumbar spinal stenosis . (wikipedia.org)
  • The objective of the NICE study is to provide clinical evidence proving that the Aperius™ PercLID™ System is safe and non-inferior to standalone decompressive surgery with regards to clinical outcomes in patients suffering from Degenerative Lumbar Spinal Stenosis with Neurogenic Intermittent Claudication, relieved by flexion. (clinicaltrials.gov)
  • Intermittent neurogenic claudication is a collection of symptoms usually caused by lumbar spinal stenosis - or narrowing of the lower spine. (laserspineinstitute.com)
  • The most commonly diagnosed cause of neurogenic claudication is certainly lumbar spinal stenosis . (cure-back-pain.org)
  • Lumbar spinal stenosis and intermittent neurogenic claudication is a disease that occurs frequently after the age of 55 and becomes complicated after the age of 65 in clinical, radiological and therapeutic aspects. (tjn.org.tr)
  • The usually intermittent nature of the pain is due to narrowing of the arteries that supply the leg with blood, limiting the supply of oxygen to the leg muscles, a limitation that is felt especially when the oxygen requirement of these muscles rises with exercise. (medical-library.net)
  • The objective of this review was to determine the effects of angioplasty of arteries in the leg when compared with non surgical therapy, or no therapy, for people with mild to moderate intermittent claudication. (altmetric.com)
  • Blockage or narrowing in any of the arteries carrying blood to the leg can cause intermittent claudication. (veins.wales)
  • Although it can also affect the arms, intermittent claudication generally affects the arteries in legs, and is a serious but treatable circulation problem. (hypervibe.com)
  • Claudication is caused by clogging arteries. (walkwithoutpain.com.au)
  • The cause of intermittent claudication is a blockage in the arteries that supply blood to your legs and elsewhere. (daynightdrugs.com)
  • Intermittent claudication is poor circulation in leg arteries due to buildup of plaque. (heart.org)
  • In addition, ginkgo may be effective for the treatment of restricted circulation in the legs due to hardening of the arteries known as intermittent claudication . (epnet.com)
  • patients with intermittent claudication due to atherosclerosis are at increased risk of death from cardiovascular disease (e.g. heart attack), because the same disease that affects the legs is often present in the arteries of the heart. (wikipedia.org)
  • Angiotensin converting enzyme inhibitors, adrenergic agents such as alpha-1 blockers and beta-blockers and alpha-2 agonists, antiplatelet agents ( aspirin and clopidogrel ), naftidrofuryl , pentoxifylline , and cilostazol (selective PDE3 inhibitor) are used for the treatment of intermittent claudication. (wikipedia.org)
  • Vasoactive drugs including cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate have marketing authorisations for the symptomatic relief of intermittent claudication and are considered in this appraisal. (nice.org.uk)
  • To estimate the cost effectiveness of cilostazol (Pletal) compared to naftidrofuryl and pentoxifylline (Trental) in the treatment of intermittent claudication in the UK. (unboundmedicine.com)
  • Using decision analytical techniques, a decision model was constructed depicting the management of intermittent claudication with cilostazol, naftidrofuryl and pentoxifylline over 24 weeks in the UK. (unboundmedicine.com)
  • AU - Guest,Julian F, AU - Davie,Alison M, AU - Clegg,John P, PY - 2005/6/23/pubmed PY - 2005/10/4/medline PY - 2005/6/23/entrez SP - 817 EP - 26 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 21 IS - 6 N2 - OBJECTIVE: To estimate the cost effectiveness of cilostazol (Pletal) compared to naftidrofuryl and pentoxifylline (Trental) in the treatment of intermittent claudication in the UK. (unboundmedicine.com)
  • Cilostazol and pentoxifylline are the only two drugs that have been approved for the treatment of patients with intermittent claudication. (portlandpress.com)
  • To assess the potential role of VEGF in the improvement in exercise tolerance, we investigated plasma levels of VEGF in 50 patients with intermittent claudication who were allocated randomly to groups receiving cilostazol ( n = 17), pentoxifylline ( n = 17) or placebo ( n = 16). (portlandpress.com)
  • This paper represents a review, by experts, of current opinion and information on intermittent claudication (IC) and the role that cilostazol plays n its treatment. (elsevier.com)
  • Two drugs are available for the management of intermittent claudication: pentoxifylline (brand name: Trental) and cilostazol (brand name: Pletal). (drugline.org)
  • Patients with severe intermittent claudication or rest pain of the lower extremities who did not improve after control of risk factors, supervised exercises, and cilostazol medication were included in this study. (podiatryarena.com)
  • Cilostazol (trade name: Pletal) is FDA approved for intermittent claudication. (wikipedia.org)
  • Conventional treatment for intermittent claudication consists of measures to combat atherosclerosis, the drug Trental (pentoxifylline), and other medications. (grandstrandmed.com)
  • Intermittent claudication is caused by arterial insufficiency (inadequate blood supply), primarily due to atherosclerosis . (digitalnaturopath.com)
  • Intermittent claudication can be due to temporary artery narrowing due to vasospasm (spasm of the artery), permanent artery narrowing due to atherosclerosis, or complete occlusion (closure) of an artery to the leg. (medical-library.net)
  • Arterial intermittent claudication is caused by a narrowing of the blood vessels in the leg due to atherosclerosis. (physiocheck.co.uk)
  • Claudication is a symptom of PAD, which is caused by atherosclerosis. (healthncare.info)
  • Intermittent claudication may be unilateral (characteristic of atherosclerosis) and bilateral (typical endarteritis). (ucoz.com)
  • The outcomes included in the trials were maximum walking distance (before having to stop because of pain), pain-free walking distance (before developing claudication pain), ankle brachial pressure index, cardiovascular events, mortality, adverse events and health-related quality of life. (nice.org.uk)
  • Stopping smoking and increasing exercise can help reduce symptoms of claudication. (nice.org.uk)
  • L-arginine has also been helpful to a large extent to get relief from the symptoms of claudication. (epainassist.com)
  • What are the symptoms of claudication? (healthsparks.org)
  • This finding implies that many patients with PAD may not have the classic symptoms of claudication. (aafp.org)
  • Pentoxifylline has been shown to improve treadmill walking distances under blinded, controlled conditions in patients with intermittent claudication. (ebscohost.com)
  • The initial claudication distance (ICD) improved 68% over baseline with pentoxifylline and 12% with placebo (p=.012) after twenty-four weeks of treatment. (ebscohost.com)
  • In this controlled trial the subset of patients with severe intermittent claudication benefited from pentoxifylline therapy. (ebscohost.com)
  • Pentoxifylline for Intermittent Claudication. (ebscohost.com)
  • Comparative Evaluation of Pentoxifylline, Buflomedil, and Nifedipine in the Treatment of Intermittent Claudication of the Lower Limbs. (ebscohost.com)
  • To review the evidence for efficacy of three contemporary treatments for intermittent claudication: pentoxifylline, exercise programs, and smoking cessation. (annals.org)
  • Antiplatelet agents, statins, and pentoxifylline (Trental) can be prescribed to patients with claudication to improve walking distance. (umsystem.edu)
  • claudicatio intermittens ), also known as vascular claudication , is a symptom that describes muscle pain on mild exertion (ache, cramp, numbness or sense of fatigue), [1] classically in the calf muscle , which occurs during exercise, such as walking, and is relieved by a short period of rest. (wikipedia.org)
  • Intermittent claudication is a symptom and is by definition diagnosed by a patient reporting a history of leg pain with walking relieved by rest. (wikipedia.org)
  • The most common symptom is muscle pain in the lower limbs on exercise-intermittent claudication. (wikipedia.org)
  • Spinal claudication manifests as weakness not pain and starts soon after standing up, with relief on sitting or bending (lumbar spine flexion). (bmj.com)
  • Intermittent claudicationis a pain in the leg that a person experiences when walking or exercising. (encyclopedia.com)
  • The pain is intermittent and goes away when the person rests. (encyclopedia.com)
  • Claudication comes from the Latin word that means "to limp," and the condition is characterized by intermittent pain in the leg muscles. (encyclopedia.com)
  • The leg pain produced by claudication is usually experienced as cramping in the thighs, calves, hips, and feet. (encyclopedia.com)
  • If the intermittent condition is not treated, the person will find that resting does not relieve pain. (encyclopedia.com)
  • Pain in the muscles of the leg that occurs off and on, usually while walking or exercising, and results in lameness (claudication). (medindia.net)
  • This can cause intermittent claudication , when cramping pain in the legs is brought on by exercise and relieved by rest. (cochrane.org)
  • Intermittent symptoms are ones that come and go at irregular and unpredictable intervals, only adding to the frustration for patients dealing with pain and limited mobility. (laserspineinstitute.com)
  • The symptoms of intermittent neurogenic claudication - pain, cramping, weakness and tingling in the lower back, buttocks and legs - may be worsened when walking or standing and can appear on one or both sides of the body. (laserspineinstitute.com)
  • Conservative treatments such as stretching, physical therapy and pain medication can often provide effective relief from neurogenic claudication for patients to resume normal activity. (laserspineinstitute.com)
  • If you have exhausted conservative treatment options and your neurogenic claudication becomes a constant source of pain, it might be time to consider Laser Spine Institute. (laserspineinstitute.com)
  • If one, or less commonly, both of your legs are aching while you are walking or exercising but the pain gradually disappears as soon as you rest you probably suffer from intermittent claudication. (biotronik.com)
  • Most often, a reduced supply of oxygen-rich blood causes the leg pain and the intermittent claudication. (biotronik.com)
  • There was also a significant increase in tPA antigen level in the patients with SC compared with those with MC and the control subjects, as well as a significant inverse correlation between tPA antigen levels and pain-free walking time in patients with claudication (p = 0.001). (biomedsearch.com)
  • Additionally, most patients have sensations of intermittent tingling and numbness, often leading up to attacks of pain and following flare-ups of acute pain. (cure-back-pain.org)
  • A total of 18 403 men aged between 40 and 64 years took part in a screening examination which included a self-administered version of the London School of Hygiene questionnaire on chest pain and intermittent claudication. (nih.gov)
  • When we tried to ascertain the presence of claudication, the patient reported burning pain in both calves during ongoing and strenuous physical exercise, such as rapid walking for more than 1000 meters, with immediate relief at rest. (ahajournals.org)
  • The intensity of intermittent claudication is often measured in the distance a person can walk without pain. (grandstrandmed.com)
  • Intermittent claudication is a predictable pattern of lower leg pain caused by inadequate blood flow to exercising muscle. (digitalnaturopath.com)
  • Often Intermittent claudication: Condition caused by interruptions of blood supply to the muscles, characterized by limping and pain chiefly in the calf muscles: symptom characterized by pain during walking. (digitalnaturopath.com)
  • The activity-induced muscle pain associated with PAD is clinically termed intermittent claudication. (oregonstate.edu)
  • There may be very short distance claudication, pain at rest, ulceration of the skin in the foot, or even gangrene in the foot or toes. (circulationfoundation.org.uk)
  • The initial symptoms of Buerger's Disease often include claudication (pain induced by insufficient blood flow during exercise) in the feet and/or hands, or pain in these areas at rest. (digitalnaturopath.com)
  • Intermittent claudication is an aching, crampy, tired, and sometimes burning pain in the legs that comes and goes. (medical-library.net)
  • In very severe claudication the pain is also felt ar rest. (medical-library.net)
  • Venous claudication is a limping and/or pain due to inadequate venous drainage, poor return of blood by the veins of the legs. (medical-library.net)
  • 2.3 The pain associated with intermittent claudication occurs because of a lack of oxygen in the leg muscles owing to the impaired blood supply. (nice.org.uk)
  • 2.5 The diagnosis of intermittent claudication includes a clinical history that assesses the presence and character of the pain. (nice.org.uk)
  • As an objective measure, walking on a treadmill, either at a fixed speed and slope, or a fixed speed and increasing slope, determines how far a patient can walk before developing claudication pain and how far a patient can walk with pain before having to stop. (nice.org.uk)
  • Intermittent claudication is calf pain that comes on when you walk. (healthtap.com)
  • Intermittent claudication is pain in the legs due to muscle ischaemia associated with arterial stenosis or occlusion. (altmetric.com)
  • Objectives The IN.PACT Global Study is the largest prospective, multicenter, independently adjudicated trial to evaluate a paclitaxel drug-coated balloon in patients with lifestyle-limiting claudication and/or ischemic rest pain due to atherosclerotic disease of the femoropopliteal artery and includes complex lesions beyond what are typically included in randomized controlled trials. (onlinejacc.org)
  • Femoropopliteal artery disease is a major cause of lifestyle-limiting claudication and ischemic rest pain. (onlinejacc.org)
  • People are not much aware of claudication or intermittent claudication and instead start believing it to pain aroused from aging or other physical activity. (epainassist.com)
  • A proper blend of these therapies is useful in getting some relief from the extreme pain of claudication. (epainassist.com)
  • Intermittent claudication is leg pain brought on by exercise. (chiropractic-help.com)
  • Intermittent claudication is leg pain brought on by exercise, relieved by rest, only to start up again when you begin walking or cycling once more. (chiropractic-help.com)
  • Intermittent Claudication is leg pain that mimics a sciatica but is caused by a blocked groin artery. (chiropractic-help.com)
  • Intermittent claudication is pain in the leg brought on by walking, and is caused by poor blood flow to the muscles. (veins.wales)
  • Calf claudication is the most frequent location of pain, and most commonly results from blockage of the superficial femoral artery in the mid-thigh. (healthncare.info)
  • by Kimberly Allen, RN Intermittent claudication is described as a "tight, aching or squeezing pain in the calf, foot, thigh or buttocks that occurs. (healthandfitnesstalk.com)
  • The reason it's called intermittent is because the pain disappears after resting. (healthandfitnesstalk.com)
  • Claudication is the pain that occurs with exercise. (healthandfitnesstalk.com)
  • So basically intermittent claudication is pain that comes and goes. (healthandfitnesstalk.com)
  • Claudication is pain and/or cramping in the lower leg due to inadequate blood flow to the muscles. (healthsparks.org)
  • Pain and cramping in the legs is the main symptom of claudication. (healthsparks.org)
  • If the blockage or plaque formation is farther up the leg, the pain from claudication may be felt in the thigh. (healthsparks.org)
  • The usually intermittent nature of the pain of claudication is due to a temporary inadequate supply of oxygen to the muscles of the leg. (healthsparks.org)
  • When symptoms do occur, leg cramp pain (intermittent claudication) is the main symptom. (adam.com)
  • Claudication is leg cramp pain that occurs during exercise, especially walking. (adam.com)
  • Intermittent means the pain comes and goes. (adam.com)
  • For people with severe arterial blockage and intermittent claudication, walking for long distances, jogging or running can be a great challenge, as the intensity of the symptoms usually limits the distance one can walk without experiencing severe pain. (hypervibe.com)
  • METHODS: Patients with PAD were classified into one of four groups according to the San Diego Claudication Questionnaire: intermittent claudication (n = 406), atypical exertional leg pain causing patients to stop (n = 125), atypical exertional leg pain in which patients were able to continue walking (n = 81), and leg pain on exertion and rest (n = 103). (podiatryarena.com)
  • Intermittent claudication is a disorder that causes calf pain. (walkwithoutpain.com.au)
  • Claudication pain won t have an impact on the first steps of the day. (walkwithoutpain.com.au)
  • When claudication is severe and persistent, these procedures may be required to ultimately relieve the condition and the pain. (drugline.org)
  • Intermittent claudication is a condition in which a person experiences aching pain in the legs when they walk or exercise, which goes away when you rest. (daynightdrugs.com)
  • Intermittent claudication is the name given to cramping or aching leg pain that occurs during exercise (such as walking) and is relieved by rest. (medicine.com)
  • With time, symptoms of intermittent claudication can worsen, and pain may occur even when not exercising. (medicine.com)
  • Medical treatment of disabling intermittent claudication or critical limb threatening ischemia causing rest pain often fails or has partial response. (podiatryarena.com)
  • In this pilot study thirty-six patients (12 females) affected by disabling intermittent claudication or rest pain of the lower extremities were exposed to a daily 3 L water intake for up to six weeks. (podiatryarena.com)
  • Cutaneous foot temperature, ankle/brachial index, time and distance of claudication and pain intensity were recorded before and at the completion of the hydration period. (podiatryarena.com)
  • Patients with a mean ± SE age of 71 ± 2 years (range 40 - 86), had disabling claudication (less than a 100 meters) for more than five months while 11 % reported pain at rest. (podiatryarena.com)
  • Medical treatment of severe intermittent claudication or critical limb-threatening ischemia causing rest pain frequently achieves only partial relief or is not effective at all. (podiatryarena.com)
  • While many cases may not show any symptoms or only mild signs of the disease, but in other instances, there could be a distinct leg pain while walking referred as intermittent claudication. (ayurvediccure.com)
  • The severity of this intermittent claudication varies from being mild to debilitating pain. (ayurvediccure.com)
  • Read more on Cochrane (Australasian Centre) website Exercise for reducing intermittent claudication symptoms Cochrane Intermittent claudication is a cramping leg pain that [healthdirect.gov.au] On physical examination, trophic changes of the skin and petechiae in the limbs were observed. (symptoma.com)
  • It is postulated that intermittent claudication per se is not an indication for sympathectomy although the operation may have a place in the treatment of early nutritional [um.edu.mt] Chemical lumbar sympathectomy for lower limb rest pain associated with thromboangiitis obliterans. (symptoma.com)
  • That pain is intermittent claudication and it can be discouraging. (wakemed.org)
  • Intermittent claudication - pain or a feeling of weakness and fatigue in the legs, occurring when walking. (ucoz.com)
  • Intermittent claudication manifests the appearance of pain, fatigue and discomfort in the legs when walking. (ucoz.com)
  • Claudication is a medical term usually referring to impairment in walking, or pain, discomfort, numbness, or tiredness in the legs that occurs during walking or standing and is relieved by rest. (wikipedia.org)
  • The perceived level of pain from claudication can be mild to extremely severe. (wikipedia.org)
  • citation needed] Jaw claudication is pain in the jaw or ear while chewing. (wikipedia.org)
  • The patient is a 79 Male with hypertension, non-insulin dependent diabetes, dyslipidemia and coronary artery disease (status post CABG), who presents with lower extremity claudication (Rutherford 4) that has progressed to pain at rest. (ccclivecases.org)
  • She presented to the office with life style limiting claudication that has progressed to pain at rest despite optimal medical and exercise therapy. (ccclivecases.org)
  • The improvement in pain related to intermittent claudication and in functional performance are probably the combined effect of various mechanisms in response to the exercise training. (viamedica.pl)
  • Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities: management of asymptomatic disease and claudication. (medscape.com)
  • Clinical outcomes attributable to managing intermittent claudication were obtained from the published literature and resource utilisation estimates were derived from a panel of vascular surgeons. (unboundmedicine.com)
  • Vascular intervention (surgery or angioplasty) treats the symptom (intermittent claudication), but not the underlying cardiovascular disease. (stir.ac.uk)
  • METHODS: Twenty participants who had received a vascular intervention for intermittent claudication between 6 months and 2 years previously participated in semistructured interviews. (stir.ac.uk)
  • In case of more serious claudication or intermittent claudication, where angioplasty or other medications do not work, doctors go for a vascular surgery. (epainassist.com)
  • More serious cases of claudication and PAD may require surgery like angioplasty or vascular surgery. (healthandfitnesstalk.com)
  • Vascular claudication is one form of intermittent claudication. (daynightdrugs.com)
  • Given that existing therapies for intermittent claudication are not appropriate for all patients, researchers are working to develop new therapies focused on improving patients' ability to compensate for a vascular occlusion by expanding collateral artery pathways. (lermagazine.com)
  • Intermittent vascular (or arterial) claudication (Latin: claudicatio intermittens) most often refers to cramping pains in the buttock or leg muscles, especially the calves. (wikipedia.org)
  • Vascular (or arterial) claudication typically occurs after activity or ambulation for a distance with resultant vascular insufficiency (lack of blood flow) where the muscular demands of oxygen outweighs the supply. (wikipedia.org)
  • The ability to ride a stationary bike for a prolonged period of time differentiates neurogenic claudication from vascular claudication. (wikipedia.org)
  • Blocking agents of the adrenoceptors alpha 1/alpha 2 are typically used to treat the effects of the vasoconstriction associated with vascular claudication. (wikipedia.org)
  • Systemic responses in patients with intermittent claudication after treadmill exercise. (biomedsearch.com)
  • Purpose - This study aimed to investigate the acute effect of intermittent walking exercise (WE) on blood pressure (BP) responses in patients with intermittent claudication (IC). (northumbria.ac.uk)
  • Current Management of Intermittent Claudication: The Role of Pharmacological and Nonpharmacological Symptom-Directed Therapies. (ebscohost.com)
  • A systematic review of randomized trials suggests that exercise improves symptoms of intermittent claudication. (digitalnaturopath.com)
  • Intermittent claudication is caused by poor circulation and is experienced in a person's muscle groups. (encyclopedia.com)
  • Intermittent claudication is most commonly associated with disease in the femoropopliteal segment of the arterial circulation. (nice.org.uk)
  • Intermittent claudication (IC) occurs due to poor blood circulation in the legs. (hypervibe.com)
  • The degree of manifestation of intermittent claudication depend on the degree of impaired circulation in the tissues. (ucoz.com)
  • Patients with PAOD were included in the study (ankle/arm ratio ≤ 0.7 and ≤ 0.5 after exercise) with initial claudication distance (ICD) ≤ 200 m and absolute claudication distance (ACD) ≤ 500 m evaluated on a constant-load treadmill test (3 km/hr, 0% slope). (elsevier.com)
  • Patients were characterized on calf muscle StO 2 before, during, and after a graded treadmill test, as well as on demographic and cardiovascular risk factors, ankle-brachial index (ABI), ischemic window, initial claudication distance (ICD), and absolute claudication distance (ACD). (elsevier.com)
  • A progressive treadmill test at baseline and at 1, 3, and 6 months of follow-up measured initial claudication distance and absolute claudication distance. (podiatryarena.com)
  • Data for 56 patients were used and showed a mean percentage increase in initial claudication distance of 187% after 3 months and 240% after 6 months. (podiatryarena.com)
  • Dahllof, A.G., Holm, J., Kral, J. and Schersten, T. (1975) The relationship between glycogen content of leg muscles and working capacity in patients with intermittent claudication. (scirp.org)
  • Intermittent claudication symptoms are most common in the calf muscles. (adam.com)
  • 3 Of the US PAD population, 10% to 12% eventually experience intermittent claudication as a result of arterial insufficiency or inadequate blood perfusion in the leg muscles. (lermagazine.com)
  • This condition, called intermittent claudication, occurs when your muscles are not receiving all the oxygen they need, and usually occurs during exercise or anytime you walk long distances. (footsmart.com)
  • Claudication results from lack of blood flow to the muscles during activity, such as walking or climbing stairs. (wakemed.org)
  • Intermittent Claudication is caused by narrowing or blockage in the main artery taking blood to your leg (femoral artery). (circulationfoundation.org.uk)
  • Unfortunately, the blockage which causes the claudication will not clear itself, but the situation can improve. (circulationfoundation.org.uk)
  • People age 50 or older are at risk of intermittent claudication. (encyclopedia.com)
  • The benefit of chelation therapy in cases of intermittent claudication is controversial. (digitalnaturopath.com)
  • In cases of intermittent claudication, clinicians should keep in mind that cervical cord compression could be a potential cause. (biomedcentral.com)
  • Supervised exercise therapy for intermittent claudication in a community-based setting is as effective as clinic-based. (ipodiatry.org)
  • Nonsurgical therapy for intermittent claudication involves risk-factor modification, exercise, and pharmacologic therapy. (aafp.org)
  • A 12-month, double-blind, placebo-controlled trial of 485 individuals with intermittent claudication evaluated the potential benefits of a special form of carnitine called propionyl-L-carnitine. (grandstrandmed.com)
  • individuals with intermittent claudication may have diabetes - often undiagnosed. (wikipedia.org)
  • Purpose: This study was conducted to determine the association between the characteristics of calf muscle hemoglobin oxygen saturation (StO 2 ) and exercise performance in patients with intermittent claudication. (elsevier.com)
  • Conclusion: In patients limited by intermittent claudication, shorter ICD and ACD values are associated with reaching a minimum value in calf muscle StO 2 sooner during treadmill exercise and with having a delayed recovery in calf muscle StO 2 after exercise. (elsevier.com)
  • One of the hallmarks of arterial claudication is that it occurs intermittently. (wikipedia.org)
  • If untreated, claudication is no longer intermittent and occurs when a person is resting. (encyclopedia.com)
  • A number of natural treatments may be helpful for intermittent claudication, but it isn't clear whether it is safe to combine them with the medications that may be prescribed at the same time. (grandstrandmed.com)
  • Though there are no proper alternate treatments introduced for the treatment of claudication or intermittent claudication, but certain therapies are helpful in preventing the symptoms. (epainassist.com)
  • Depending on the severity of your claudication your doctor may also recommend a combination of treatments. (healthandfitnesstalk.com)
  • Compared with medical management, each of the three treatments (surgery, endovascular therapy, and exercise therapy) was associated with improved walking distance, claudication symptoms, and quality of life (high-quality evidence). (elsevier.com)
  • Naftidrofuryl (Praxilene®) is a vasodilator that has been used in the treatment of intermittent claudication for >30 years in Europe to improve walking distance and provide symptomatic relief. (ebscohost.com)
  • This was a modelling study on the management of patients with intermittent claudication who are 40 years of age or above and have at least six months history of symptomatic intermittent claudication, secondary to lower extremity arterial occlusive disease. (unboundmedicine.com)
  • Neurogenic intermittent claudication describes a set of debilitating symptoms most often associated with lumbar central spinal canal stenosis. (cure-back-pain.org)
  • Treatment for neurogenic intermittent claudication usually centers on resolving the spinal stenosis thought to be at the heart of the problem. (cure-back-pain.org)
  • There is also venous claudication, resulting from inadequate venous drainage. (drugline.org)
  • Claudication is not usually limb threatening and it is not necessary to treat it if the symptoms are mild. (circulationfoundation.org.uk)
  • Claudication represents the most prevalent limb ischemic symptom, affecting 1-3 million Americans. (nih.gov)
  • However, it had a lower limb ischemia of tissues during walking and the manifestation of symptoms such as intermittent claudication. (ucoz.com)
  • Regional ischemia of the lumbar nerve roots is the underlying mechanism for neurogenic claudication to occur, but this oxygen deprivation does not necessarily have to originate due to structural compression. (cure-back-pain.org)
  • Intermittent claudication most commonly manifests in men older than 50 years. (wikipedia.org)
  • From the pooled data of a blinded, controlled, randomized, multicenter trial, the data from all enrolled patients with severe claudication ( (ebscohost.com)
  • Intermittent claudication is the primary symptom of PAD, the condition causing reduced flow of blood and oxygen to tissues. (encyclopedia.com)
  • Preclinical and clinical evidence suggests targeting Nox-derived reactive oxygen species is a viable strategy for prevention and treatment of intermittent claudication. (lermagazine.com)
  • Endovascular stents for intermittent claudication: Cochrane systematic review is a topic covered in the Cochrane Abstracts . (unboundmedicine.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/431713/all/Endovascular_stents_for_intermittent_claudication:_Cochrane_systematic_review. (unboundmedicine.com)
  • Intermittent claudication may occur in one or both legs and often continues to worsen over time. (medical-library.net)
  • Intermittent means it doesnt occur every time but from time to time. (healthtap.com)
  • Foot claudication may occur from narrowing of an artery in the lower part of the leg (the tibial or peroneal artery). (healthncare.info)
  • Intermittent claudication may occur in both legs, and the symptoms often get worse over time. (heart.org)
  • Randomised trials of angioplasty for mild or moderate intermittent claudication. (altmetric.com)
  • The symptoms of intermittent claudication vary from mild to severe. (daynightdrugs.com)
  • Is restless leg syndrome the same as intermittent claudication of your legs? (healthtap.com)
  • Weakness is also a prominent feature of spinal claudication that is not usually present in intermittent claudication. (wikipedia.org)
  • Furthermore, intermittent claudication is related to a two to three times increased risk of coronary heart disease , stroke, or cardiac failure in men with diabetes, according to the association. (encyclopedia.com)
  • Fibrinogen in relation to personal history of prevalent hypertension, diabetes, stroke, intermittent claudication, coronary heart disease, and family history: the Scottish Heart Health Study. (bmj.com)
  • Cardiovascular risk factors associated with development of PAD and intermittent claudication include aging, hypertension, and diabetes or metabolic syndrome. (lermagazine.com)
  • Only arterial hypertension and intermittent claudication severity emerged as negative predictive factors for the results of training. (elsevier.com)
  • The treatment of intermittent claudication depends on the cause and severity of it. (daynightdrugs.com)
  • Participants completed questionnaires on claudication severity and quality of life at baseline. (nih.gov)
  • The mean percentage of the absolute claudication distance increased 142% after 3 months and 191% after 6 months. (podiatryarena.com)
  • The ankle-brachial index and functional outcomes, defined as speed at the onset of claudication and attainable maximal speed by an incremental treadmill test, were assessed at baseline and discharge. (nih.gov)
  • This study reports the prevalence of intermittent claudication (IC) in ambulatory community-resident adults age 65 years or older, compares cardiovascular risk factors and comorbidity of persons with and without IC, and examines the independent association of IC in predicting all cause and cardiovascular mortality, myocardial infarction, stroke, and disability. (elsevier.com)
  • Claudication predicted higher rates of mortality, myocardial infarction, stroke, and disability independent of associated cardiovascular conditions and risk factors. (elsevier.com)
  • de Backer TLM, Vander Stichele R, Lehert P, Van Bortel L. Naftidrofuryl for intermittent claudication. (cochrane.org)
  • Comparison of Safety and Efficacy of Buflomedil and Naftidrofuryl in the Treatment of Intermittent Claudication. (ebscohost.com)
  • Naftidrofuryl: A Review of its Use in the Treatment of Intermittent Claudication. (ebscohost.com)
  • Spinal stenosis, intermittent claudication. (tjn.org.tr)
  • Under severe intermittent claudication, it becomes extremely hard to walk or perform physical activities. (ayurvediccure.com)
  • Search terms included exercise, intermittent claudication and muscle. (scirp.org)
  • Claudication that appears after a short amount of walking may sometimes be described by US medical professionals by the number of typical city street blocks that the patient can walk before the onset of claudication. (wikipedia.org)