Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
International organizations which provide health-related or other cooperative services.
Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.
A family of inwardly-rectifying potassium channels that are activated by PERTUSSIS TOXIN sensitive G-PROTEIN-COUPLED RECEPTORS. GIRK potassium channels are primarily activated by the complex of GTP-BINDING PROTEIN BETA SUBUNITS and GTP-BINDING PROTEIN GAMMA SUBUNITS.
CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Progenitor cells from which all blood cells derive.
Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.
In Chinese philosophy and religion, two principles, one negative, dark, and feminine (yin) and one positive, bright, and masculine (yang), from whose interaction all things are produced and all things are dissolved. As a concept the two polar elements referred originally to the shady and sunny sides of a valley or a hill but it developed into the relationship of any contrasting pair: those specified above (female-male, etc.) as well as cold-hot, wet-dry, weak-strong, etc. It is not a distinct system of thought by itself but permeates Chinese life and thought. A balance of yin and yang is essential to health. A deficiency of either principle can manifest as disease. (Encyclopedia Americana)
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Tumors or cancer of the LUNG.
New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
Tumors or cancer of the BRONCHI.
The movement of cells or organisms toward or away from a substance in response to its concentration gradient.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Hormones released from neoplasms or from other cells that are not the usual sources of hormones.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.
Rod-shaped storage granules for VON WILLEBRAND FACTOR specific to endothelial cells.
The minute vessels that collect blood from the capillary plexuses and join together to form veins.
Former state in north central Germany. Formally abolished March 1, 1947. Kingdom established 1701.
A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Organic compounds that contain the -NCO radical.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
The nonstriated involuntary muscle tissue of blood vessels.

Dysregulated production of interleukin-8 in individuals infected with human immunodeficiency virus type 1 and Mycobacterium tuberculosis. (1/5836)

Interleukin-8 (IL-8) production in vivo was monitored in four study groups: normal blood donors, patients with pulmonary tuberculosis (TB), patients with human immunodeficiency virus type 1 (HIV-1) infection, and dually infected (HIV/TB) patients. We show that whereas there was evidence of detectable levels of cell-associated IL-8 (mRNA and protein) in peripheral cells of healthy individuals, this was largely lost in the disease states studied. Coupled with this finding was significantly increased circulating levels of IL-8 in HIV-1-infected individuals with or without concomitant pulmonary TB (P < 0.001). On the other hand, the capacity of peripheral mononuclear cells to produce IL-8 spontaneously ex vivo was enhanced in HIV-1 and TB patients (P < 0.05) and many of the HIV/TB group, but their corresponding capacities to respond to various stimuli, in particular phytohemagglutinin, were significantly diminished compared to those of normal donors (P < 0.05). Circulating levels of IL-8 in a group of HIV/TB patients were significantly positively correlated with the percentage of polymorphonuclear leukocytes (PMN) in the peripheral circulation (r = 0.65; P = 0.01), the proportions of IL-8 receptor A (IL-8RA)-expressing (r = 0.86; P < 0.01) and IL-8RB-expressing (r = 0.77; P < 0.01) PMN, and the capacity of PMN to migrate in response to IL-8 as chemoattractant (r = 0.68; P < 0. 01). IL-8RB fluorescence intensity, however, was negatively correlated with plasma IL-8 levels (r = -0.73; P < 0.01). Our results suggest that altered regulation of IL-8 in HIV-1 may have important implications for antimicrobial defenses and for normal immune processes.  (+info)

Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes. (2/5836)

We have previously shown that different isolates of Chlamydia pneumoniae display heterogeneity in the in vitro stimulation of chemokines and adhesion molecules from infected human endothelial cells. In the present study, we examined the ability of different isolates of C. pneumoniae to promote transendothelial migration of neutrophils and monocytes. Human umbilical vein endothelial cells (HUVEC) were infected with low (<15)-passage C. pneumoniae isolates A-03, PS-32, and BR-393 and high (>40)-passage isolates BAL-16, TW-183, and T-2634, and levels of neutrophil and monocyte transendothelial migration were determined following 24 h of infection. Compared to mock-infected controls, significant increases in neutrophil migration were observed in response to most C. pneumoniae isolates examined (P < 0.001). Levels of monocyte migration were significantly increased in response to TW-183 and T-2634 (P < 0.001). Serial passage (>40 times) of the three low-passage isolates in HEp-2 cell cultures prior to infection of HUVEC generally resulted in the promotion of higher levels of neutrophil and monocyte transendothelial migration. These findings were compatible with differences observed in the extent of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) stimulation between low- and high-passage A-03, PS-32, and BR-393. As opposed to C. pneumoniae, infection with C. trachomatis L2 caused only a slight increase in neutrophil transendothelial migration, which correlated with the lack of measurable IL-8 levels by this species. However, significant levels of monocyte migration were induced in response to C. trachomatis L2 despite a lack of measurable MCP-1 stimulation. C. trachomatis serovars A and E also failed to induce IL-8 and MCP-1 production in HUVEC. Results from this study indicate that the passage history of C. pneumoniae may play a role in the divergence of stimulatory activities observed among isolates in human endothelial cells. In addition, the differences observed between this organism and C. trachomatis suggest that the upregulation of IL-8 and MCP-1 in endothelial cells may be unique to C. pneumoniae.  (+info)

Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. (3/5836)

Endothelial damage is characteristic of infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). Because Stx-mediated endothelial cell damage at the site of infection may lead to the characteristic hemorrhagic colitis of STEC infection, we compared the effects of Stx1 and Stx2 on primary and transformed human intestinal microvascular endothelial cells (HIMEC) to those on macrovascular endothelial cells from human saphenous vein (HSVEC). Adhesion molecule, interleukin-8 (IL-8), and Stx receptor expression, the effects of cytokine activation and Stx toxins on these responses, and Stx1 and Stx2 binding kinetics and bioactivity were measured. Adhesion molecule and IL-8 expression increased in activated HIMEC, but these responses were blunted in the presence of toxin, especially in the presence of Stx1. In contrast to HSVEC, unstimulated HIMEC constitutively expressed Stx receptor at high levels, bound large amounts of toxin, were highly sensitive to toxin, and were not further sensitized by cytokines. Although the binding capacities of HIMEC for Stx1 and Stx2 were comparable, the binding affinity of Stx1 to HIMEC was 50-fold greater than that of Stx2. Nonetheless, Stx2 was more toxic to HIMEC than an equivalent amount of Stx1. The decreased binding affinity and increased toxicity for HIMEC of Stx2 compared to those of Stx1 may be relevant to the preponderance of Stx2-producing STEC involved in the pathogenesis of hemorrhagic colitis and its systemic complications. The differences between primary and transformed HIMEC in these responses were negligible. We conclude that transformed HIMEC lines could represent a simple physiologically relevant model to study the role of Stx in the pathogenesis of hemorrhagic colitis.  (+info)

Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. (4/5836)

In shigellosis, the network of cellular interactions mediated by a balance of pro- and anti-inflammatory cytokines or chemokines is clearly tipped toward acute destructive inflammation of intestinal tissues by the bacterial invader. This work has addressed the role played by interleukin-8 (IL-8) in a rabbit model of intestinal invasion by Shigella flexneri. IL-8, which is largely produced by the epithelial cells themselves, appears to be a major mediator of the recruitment of polymorphonuclear leukocytes (PMNs) to the subepithelial area and transmigration of these cells through the epithelial lining. Neutralization of IL-8 function by monoclonal antibody WS-4 caused a decrease in the amount of PMNs streaming through the lamina propria and the epithelium, thus significantly attenuating the severity of epithelial lesions in areas of bacterial invasion. These findings are in agreement with our previous work (31). In contrast to the PMNs, the bacteria displayed increased transepithelial translocation, as well as overgrowth in the lamina propria and increased passage into the mesenteric blood. By mediating eradication of bacteria at their epithelial entry site, although at the cost of severe epithelial destruction, IL-8 therefore appears to be a key chemokine in the control of bacterial translocation.  (+info)

Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. (5/5836)

BACKGROUND: cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. AIM: To characterise cagA and the cag PAI in Japanese H pylori strains. METHODS: H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from Western countries were also studied. Induction of interleukin-8 secretion from gastric epithelial cells was also investigated. RESULTS: All Japanese strains retained cagA. Fifty nine of 63 (94%) strains had all the cag PAI genes. In the remaining four, cag PAI was partially deleted, lacking cagA transcripts and not producing CagA protein. Details of the PAI of these strains were checked; three lacked cagB to cagQ (cagI) and continuously cagS to cag13 (cagII), and the remaining one lacked cagB to cag8. Western cagA negative strains completely lacked cag PAI including cagA. Nucleotide sequence analysis in one strain in which the cag PAI was partially deleted showed that the partial deletion contained 25 kb of cag PAI and the cagA promoter. Interleukin-8 induction was lower with the cag PAI partial deletion strains than with the intact ones. All Japanese cag PAI deleted strains were derived from patients with non-ulcer dyspepsia, whereas 41 of 59 (70%) CagA-producing strains were from patients with peptic ulcers or gastric cancer (p<0.05). CONCLUSIONS: Most Japanese H pylori strains had the intact cag PAI. However, some lacked most of the cag PAI in spite of the presence of cagA. Thus the presence of the cagA gene is not an invariable marker of cag PAI related virulence in Japanese strains.  (+info)

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. (6/5836)

Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and permeability factor that is potently angiogenic in vivo. We report here studies that suggest that VEGF potentiates angiogenesis in vivo and prolongs the survival of human dermal microvascular endothelial cells (HDMECs) in vitro by inducing expression of the anti-apoptotic protein Bcl-2. Growth-factor-enriched and serum-deficient cultures of HDMECs grown on collagen type I gels with VEGF exhibited a 4-fold and a 1.6-fold reduction, respectively, in the proportion of apoptotic cells. Enhanced HDMEC survival was associated with a dose-dependent increase in Bcl-2 expression and a decrease in the expression of the processed forms of the cysteine protease caspase-3. Cultures of HDMECs transduced with and overexpressing Bcl-2 and deprived of growth factors showed enhanced protection from apoptosis and exhibited a twofold increase in cell number and a fourfold increase in the number of capillary-like sprouts. HDMECs overexpressing Bcl-2 when incorporated into polylactic acid sponges and implanted into SCID mice exhibited a sustained fivefold increase in the number of microvessels and a fourfold decrease in the number of apoptotic cells when examined 7 and 14 days later. These results suggest that the angiogenic activity attributed to VEGF may be due in part to its ability to enhance endothelial cell survival by inducing expression of Bcl-2.  (+info)

Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. (7/5836)

Preliminary studies indicate the involvement of interleukin (IL)-12 in experimental renal pathology. In the present study, we evaluated whether cultured glomerular mesangial cells are able to produce IL-12 and whether IL-12 may regulate some of their functions, including the cytoskeletal reorganization, the change in cell shape, and the production of platelet-activating factor (PAF). The results obtained indicate that pro-inflammatory stimuli, such as tumor necrosis factor-alpha and bacterial polysaccharides, induce the expression of IL-12 mRNA and the synthesis of the protein by cultured mesangial cells. Moreover, cultured mesangial cells were shown to bind IL-12 and to express the human low-affinity IL-12 beta1-chain receptor. When challenged with IL-12, mesangial cells produced PAF in a dose- and time-dependent manner and superoxide anions. No production of tumor necrosis factor-alpha and IL-8 was observed. Moreover, we demonstrate that IL-12 induced a delayed and sustained shape change of mesangial cells that reached its maximum between 90 and 120 minutes of incubation. The changes in cell shape occurred concomitantly with cytoskeletal rearrangements and may be consistent with cell contraction. As IL-12-dependent shape change of mesangial cells was concomitant with the synthesis of PAF, which is known to promote mesangial cell contraction, we investigated the role of PAF using two chemically different PAF receptor antagonists. Both antagonists inhibited almost completely the cell shape change induced by IL-12, whereas they were ineffective on angiotensin-II-induced cell shape change. In conclusion, our results suggest that mesangial cells can either produce IL-12 or be stimulated by this cytokine to synthesize PAF and to undergo shape changes compatible with cell contraction.  (+info)

Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. (8/5836)

BACKGROUND: In neutrophil trafficking, the role of interleukin-8 (IL-8) is location dependent. Tissue IL-8 directs transmigration, whereas intravascular IL-8 frustrates this process. The bystander damage of glomerular endothelium by antineutrophil cytoplasmic autoantibody (ANCA)-activated neutrophils is believed to be an early event in the pathogenesis of ANCA-associated glomerulonephritis. We have studied the role of IL-8 in this process. METHODS: Intraglomerular expression of IL-8 in patients with ANCA-associated glomerulonephritis was studied by in situ hybridization and immunohistochemistry and location of neutrophils by serial section immunohistochemistry. In vitro, we analyzed ANCA-stimulated neutrophil IL-8 production by enzyme-linked immunosorbent assay, and the IL-8 attributable effect of ANCA-stimulated neutrophil supernatant by chemotactic and transendothelial assays. RESULTS: There was intraglomerular expression of IL-8 at segmental, crescentic, and parietal epithelial sites. IL-8 protein expression colocalized to intraglomerular neutrophils; many localized within glomerular capillary loops, suggesting failed trafficking to tissue IL-8. ANCAs differentially stimulated time- and dose-dependent neutrophil IL-8 production, and ANCA-stimulated neutrophil supernatant demonstrated potent IL-8-dependent chemotactic activity and inhibited transendothelial migration of normal human neutrophils toward an IL-8 gradient. CONCLUSION: Despite heavy tissue expression of IL-8 in ANCA-associated GN, the production of IL-8 by ANCA-stimulated neutrophils within the intravascular compartment may frustrate neutrophil transmigration, encourage intravascular stasis, and contribute to bystander damage of glomerular endothelial cells.  (+info)

TY - JOUR. T1 - Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1. AU - Leonard, Edward J.. AU - Yoshimura, Teizo. AU - Tanaka, Shuji. AU - Raffeld, Mark. PY - 1991/5. Y1 - 1991/5. N2 - Neutrophil attractant/activation protein-1 (NAP-1) is a recently described cytokine that attracts neutrophils, but not monocytes or eosinophils. This leukocyte specificity is not absolute, in that NAP-1 attracts basophils and small numbers of lymphocytes. Our purpose was to determine in vivo effects of NAP-1, and to compare them to the reported action of the complement attractant, C5a. Intradermal injection into normal human subjects of 40 μl of NAP-1, over a concentration range of 4 × 10-8 M to 10-6 M, caused no symptoms or signs such as wheal-and-flare, itching, induration, or tenderness. However, biopsies of injection sites showed perivascular neutrophil infiltration as early as 30 min, which increased at 1 and 3 h. The mean number of neutrophils per mm2 of dermis ...
In this study we focused on the cellular infiltration in the bronchial mucosa of patients with post-infective bronchiectasis compared with corresponding bronchial biopsy specimens from normal healthy control subjects. The striking finding was an intense cellular infiltrate (with increased CD45+ cell numbers) with mononuclear cells (CD4+ T lymphocytes and macrophages), a prominent neutrophilia, and increased expression of the potent neutrophil chemoattractant IL-8. In those patients with bronchiectasis treated with inhaled steroids the T cell infiltrate (CD4+ cells) was significantly lower than in untreated patients. These findings support a role for cell mediated immune mechanisms in the pathogenesis of ongoing airways damage in bronchiectasis and its possible modulation by topical corticosteroids.. Previous immunohistological studies of bronchiectasis3 4performed in an experimental rat model of bronchiectasis and on human subjects have identified a relative increase in CD8+ T lymphocytes in ...
Interactions between the enteric pathogen Salmonella typhimurium and the luminal surface of the intestine provoke an acute inflammatory response, mediated in part by epithelial cell secretion of the chemokine IL-8 and other proinflammatory molecules. This study investigated the mechanism by which this pathogen induces IL-8 secretion in physiologically polarized model intestinal epithelia. IL-8 secretion induced by both the prototypical proinflammatory cytokine TNF-α and S. typhimurium was NF-κB dependent. However, NF-κB activation and IL-8 secretion induced by S. typhimurium, but not by TNF-α, was preceded by and required an increase in intracellular [Ca2+]. Additionally, agonists that increased intracellular [Ca2+] by receptor-dependent (carbachol) or independent (thapsigargin, ionomycin) means also induced IL-8 secretion. Furthermore, the ability of S. typhimurium mutants to induce IκB-α degradation, NF-κB translocation, and IL-8 transcription and secretion correlated precisely with ...
IL-8 is a potent neutrophil chemoattractant that has been detected in high concentrations at acutely inflamed sites in vivo. Many cell types, including peripheral blood neutrophils, produce IL-8 that can be released by a variety of pro-inflammatory stimuli. However, the functional importance of neutrophil IL-8 during exudation is not yet known. We now report that neutrophils, harvested from skin lesions on the forearms of normal human volunteers (exudative neutrophils), expressed 100-fold higher levels of cell-associated IL-8 and spontaneously released up to 50-fold more IL-8 than freshly isolated peripheral blood neutrophils from the same donor. Furthermore, cell-associated IL-8 in peripheral blood neutrophils increased 20-fold during incubation at 37 degrees C in vitro and was increased over 200-fold after treatment with the Ca2+ ionophore A23187. More than 35% of the cell-associated IL-8 could be released by stimulation with either Ca2+ ionophore A23187 or phorbol myristate acetate. IL-8 was ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Primary human lung cells or cell lines were cultured on a stretchable silastic membrane forming the bottom of a 12-well plexiglas® box. The box was connected to an adult ventilator and ventilated for up to 36 hours at 20 cycles/min with a pressure-volume regimen resembling that of MV. Several lung cell types were tested in this model. The alveolar macrophage was identified as the main cellular source of key inflammatory mediators, such as tumor necrosis factor, the chemokine interleukin (IL)-8, and matrix metalloproteinase-9, produced during mechanical ventilation. Mechanical ventilation also induced low levels of IL-8 secretion by human alveolar epithelial type II-like cells. Other lung cell types such as endothelial cells, bronchial cells, and fibroblasts failed to produce IL-8 in response to mechanical ventilation (1,2). Conclusions and Relevance for 3R ...
Using thapsigargin (Tg), an agent that mobilizes calcium by directly emptying intracellular stores, we previously showed that intracellular calcium may play an important role in the regulation of intercellular adhesion molecule (ICAM)-1 gene expression induced by cytokines in human airway smooth muscle (ASM) cells. In the present study, we extended this previous observation by comparing the effect of Tg and other calcium-mobilizing G-protein-coupled receptor (GPCR) agonists on the expression of different pro-inflammatory genes in response to tumor necrosis factor (TNF)-alpha in ASM cells. We found that in resting cells, Tg (10-100 nM) or the bradykinin (BK) (1-10 muM) and thrombin (Thr) (1 U/ml) stimulated interleukin (IL)-6 secretion but had no effect on regulated on activation, normal T cells expressed and secreted (RANTES) levels. More importantly, such calcium-mobilizing agents significantly enhanced TNF-alpha-induced IL-6 secretion while RANTES secretion was abrogated. The use of ...
Rat CXCL2/MIP-2 (macrophage inflammatory protein-2) is a 69-amino acid CXC chemokine. MIP-2 is induced during acute inflammation in rat models of disease. It is a potent neutrophil chemotactic factor both |i|in vitro|/i| and|i| in vivo|/i|.
Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, ONeal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. J Clin Invest. 2019 01 02; 129(1):169-181 ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Power C.A., Furness R.B., Brawand C., Wells T.N.C. (1994). Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets.. Gene 151: 333 - 334. PubMed DOI:10.1016/0378-1119(94)90682-3 ...
TY - JOUR. T1 - Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence. AU - Teizo, Yoshimura. AU - Robinson, Elizabeth A.. AU - Appella, Ettore. AU - Matsushima, Kouji. AU - Showalter, Stephen D.. AU - Skeel, Alison. AU - Leonard, Edward J.. PY - 1989/1. Y1 - 1989/1. N2 - Human monocyte-derived neutrophil chemotactic factor (MDNCF) was purified from culture supernatant of lipopolysaccharide-stimulated human peripheral blood mononuclear leukocytes on a column of Sepharose-bound murine monoclonal anti-MDNCF. About 65% of the culture fluid chemotactic activity was bound to the column. The unbound 35% probably represents chemotactic activity of other cytokines in the culture fluid. More than 85% of the bound activity was eluted by pH 2.5 glycine buffer. When this material was applied to an HPLC-CM column, gradient elution produced four well-separated A280 peaks, each of which had chemotactic activity. N-terminal amino ...
Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. It is also known as RANTES (regulated on activation, normal T cell expressed and secreted). CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also an HIV-suppressive factor released from CD8+ T cells[citation needed]. This chemokine has been localized to chromosome 17 in humans. RANTES was first identified in a search for genes expressed late (3-5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is ...
Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells an
Results In C57BL/6 mice, gefitinib decreased Cxcl1 and Cxcl2 expression by gastric epithelial cells, myeloperoxidase-positive inflammatory cells in the mucosa and epithelial DNA damage induced by H. pylori infection. Similar reductions in chemokines, inflammatory cells and DNA damage occurred in infected EgfrΔepi versus Egfrfl/fl control mice. In H. pylori-infected transgenic insulin-gastrin (INS-GAS) mice and gerbils, gefitinib treatment markedly reduced dysplasia and carcinoma. Gefitinib blocked H. pylori-induced activation of mitogen-activated protein kinase 1/3 (MAPK1/3) and activator protein 1 in gastric epithelial cells, resulting in inhibition of chemokine synthesis. MAPK1/3 phosphorylation and JUN activation was reduced in gastric tissues from infected wild-type and INS-GAS mice treated with gefitinib and in primary epithelial cells from EfgrΔepi versus Egfrfl/fl mice. Epithelial EGFR activation persisted in humans and mice after H. pylori eradication, and gefitinib reduced gastric ...
These studies demonstrate that GM-CSF is a neutrophil chemotactic agent. The concentration of GM-CSF needed to achieve maximal chemotaxis is comparable to that of the potent neutrophil chemoattractant IL-8 and less than the other known chemoattractants that we studied. We believe that GM-CSF induction of neutrophil chemotaxis has been previously unrecognized because the stimulatory effect occurs in a narrow range of concentrations (Fig. 3⇑A) and requires an extended incubation interval of at least 30 min. Results reported by Harakawa et al. (44) agreed with our finding that GM-CSF produces an early stimulation of neutrophil chemokinesis, but observations were not reported past 15 min, which may have been insufficient to recognize an effect on chemotaxis. Other earlier studies provided contradictory data on the effect of GM-CSF on neutrophil migration. In a checkerboard assay using polycarbonate filters, Wang et al. (45) demonstrated that GM-CSF induced chemotaxis in neutrophils, while Kharazmi ...
Chemokines are a large group of chemotactic cytokines that play an important pathogenic role in inflammatory diseases and autoimmune disorders by enhancement of leukocyte recruitment and activation at inflammatory sites [3-6]. ENA-78 is a CXC chemokine that attracts neutrophils during inflammation [7].. In this work, serum levels of ENA-78 were significantly higher in autistic children than healthy control children (P , 0.001). In addition, 69.35% of autistic children had increased serum levels of ENA-78. This study was the first to investigate serum levels of ENA-78 in autistic children. ENA-78 is an inflammatory C-X-C chemokine that is encoded by the CXCL5 gene [28]. Its levels are elevated in myriad inflammatory conditions [29-32].. ENA-78 is an α chemokine which is produced concomitantly with IL-8 and melanoma growth stimulating activity [7]. The main stimuli for secretion of chemokines, including ENA-78, are the early signals elicited during innate immune response such as bacterial ...
A potential new strategy to developing new drugs to control inflammation without serious side effects has been found by Georgia State University researchers and international colleagues.. Jian-Dong Li, director of Georgia States Center for Inflammation, Immunity and Infection, and his team discovered that blocking a certain pathway involved in the biological process of inflammation will suppress it.. Inhibiting a molecule called phosphodiesterase 4B, or PDE4B, suppresses inflammation by affecting a key gene called CLYD, a gene that serves as a brake on inflammation.. The research was published in the journal Nature Communications.. Li explained the process of overactive inflammation using a police analogy.. When a pathogen - such as bacteria or viruses -- infects a patient, he said, it triggers an alarm to which the police of immune system respond. In turn, it triggers neutrophil attractant called cytokines to respond, leading to inflammation that serves to help rid the body of the ...
CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.[6] It is also an HIV-suppressive factor released from CD8+ T cells[citation needed]. This chemokine has been localized to chromosome 17 in humans.[5]. RANTES was first identified in a search for genes expressed late (3-5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13).[7][8][9][10] RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive ...
Human IL-16 (hIL-16) is a homotetrameric cytokine with chemotactic properties towards cells expressing the CD4 receptor. This chemotactic cytokine plays an important role in attracting cells of the immune system to the site where CD8+ T-cells were activated for example by a foreign antigen. In addition to the chemotactic activity, hIL-16 also induces expression of IL-2 receptor, increasing the responsiveness to IL-2 and therefore implying a role for specific expansion of the CD4+ T-cell population in an area of induced inflammation. In this report we describe the cloning, sequencing and the expression of feline IL-16 (fIL-16). At the nucleotide level, fIL-16 shows 84.6 and 84.5%, on the amino acid level 93 and 91.5% identity to the human and African green monkey (agm) IL-16, respectively. ...
Methods Quiescent cultured RASMCs were pretreated with E2 or vehicle for 24 hours before tumor necrosis factor (TNF)-α was added. After 6 hours of treatment, total RNA was extracted from cells using TRIzol reagent, and SYBR green real-time RT-PCR was used to detect expression of CINC-2 mRNA. Conditioned media was collected and concentrated to measure CINC-2 protein level by ELISA. To assess neutrophil chemotactic activity of conditioned media, in vitro chemotaxis assays were performed using differentiated HL-60 cells in a 96-well modified Boyden chamber appropriate for the evaluation of leukocyte chemotaxis. The nonselective ER antagonist ICI-182780 was given to cells 2 hours prior to E2 incubation to study the mechanism of E2 effect. ...
Primobolan side effects is a selective agonist of beta2-adrenergic receptors. At therapeutic doses it acts on beta2-adrenergic receptors of smooth muscles of the bronchi, providing pronounced bronchodilator effect, prevents and relieves bronchospasm, increases lung capacity. It prevents the release of histamine, slow reacting substances from mast cells and neutrophil chemotactic factors. It is a small …. Read more ...
Primobolan side effects is a selective agonist of beta2-adrenergic receptors. At therapeutic doses it acts on beta2-adrenergic receptors of smooth muscles of the bronchi, providing pronounced bronchodilator effect, prevents and relieves bronchospasm, increases lung capacity. It prevents the release of histamine, slow reacting substances from mast cells and neutrophil chemotactic factors. It is a small …. Read more ...
Inhibition of LPS induced sputum neutrophil percentage. The reduction in sputum neutrophil percentage caused by active treatments compared to placebo are shown;
CXCL5 protein is expressed in E. coli, processed, refolded and purified to yield the native, secreted form of the mature chemokine. C-X-C motif chemokine 5 (CXCL5) or epithelial-derived neutrophil-activating peptide 78 (ENA-78) is a protein that in humans
HSV-1 infected keratinocytes release IL-1αPrimary human keratinocytes were treated with medium only, 25 μg ml-1 poly(I:C), or HSV-1 as indicated. After one ho
Abstract: : Purpose: Adenovirus infection of the cornea manifests as punctate epithelial keratitis, geographic epithelial erosions, and delayed-onset subepithelial corneal infiltrates. We have previously shown that (1)adenovirus type 19 (Ad19) infection of human corneal fibroblasts (HCF) induces expression of the neutrophil chemokine interleukin-8 (IL-8); (2) Ad19 infection of HCF induces tyrosine phosphorylation of the intracellular signaling protein c-src; and (3) phosphorylation of c-src is necessary for the expression of IL-8 by Ad19-infected HCF. These data suggest that Ad19 induces IL-8 expression in HCF by a signaling cascade involving c-src. In the experiments described herein, we sought to determine whether adenovirus infection of HCF might induce other host responses dependent on c-src associated signaling pathways. Methods: HCF were derived from donor corneas and infected for one hour with Ad19, or mock-infected with virus-free media. Parallel experiments were performed with the ...
Schizophrenia patients typically exhibit cognitive impairments that directly affect their daily functioning, but are not effectively treated by current antipsychotics. Maternal immune activation (MIA) during pregnancy, which can be triggered by a variety of infectious agents, has been associated with the development of schizophrenia in adult offspring. Epidemiological evidence indicates that elevated maternal levels of the chemokine interleukin- 8 (IL-8) during MIA contribute to the neurodevelopmental alterations underlying the disorder. The present experiments used an animal model of neurodevelopmental disorders to study the effects of MIA and chemokine receptor antagonism on the behavior of rat offspring, with behavioral tests chosen to examine cognitive functions that are typically impaired in human schizophrenia patients. The viral mimetic polyinosinic-polycytidylic acid (polyI:C) (4.0 mg/kg, i.v.) was injected into pregnant Long-Evans (LE) dams on gestational day (GD) 15. Dams were also ...
TY - JOUR. T1 - Increased expression of epidermal interleukin-8 receptor in psoriasis. Downregulation by FK-506. AU - Schulz, B. S.. AU - Michel, G.. AU - Wagner, S.. AU - Suss, R.. AU - Angerpoitner, T.. AU - Kemeny, L.. AU - Ruzicka, T.. PY - 1994/12/1. Y1 - 1994/12/1. N2 - IL-8 is a chemotactic cytokine with proinflammatory and growth promoting activities. Recently it has been shown to influence several functions of keratinocytes, including HLA-DR expression, chemotaxis and proliferation by binding to a specific receptor. Since psoriasis vulgaris is characterized by epidermal hyperproliferation and infiltration of inflammatory cells, we investigated the expression of IL-8 and its receptor in normal and psoriatic epidermis using semiquantitative reverse-transcriptase-PCR. In addition the mRNA levels of the protooncogenes c-ras, c-raf, c-myc and HER-2 were also investigated as potential growth promoting stimuli in psoriatic epidermis. IL-8 mRNA was only detected in lesional psoriatic epidermis, ...
Bronchial Epithelial Cell Medium-basal-phenol red free ...
Bronchial Epithelial Cell Medium-basal ...
Dirofilaria immitis neutrophil chemotactic factor: aa sequence given in first source; isolated from the adult worm; GenBank D11438
AIM Behcets disease (BD) is a systemic immunoinflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha, interleukin-1beta (IL-1beta), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. We also determined the end product of lipid peroxidation (malondialdehyde (MDA)) in BD patients as an index for oxidative stress. ...
Chemokine ligand 5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78.
Recombinant Human CXCL5 (ENA-78) (ELISA Std.) - CXCL5 is a member of the CXC family of chemokines, also known as epithelial activated peptide 78 (ENA-78).
Interleukins are naturally occurring proteins that help the bodys immune system. The different types of interleukins all serve to...
It is a formaldehyde-free, next generation smoothing system that uses the latest advances in science, along with only the finest ingredients, to create a product that delivers the results of a traditional keratin smoothing treatment without the harmful chemicals ...
有多种机制认为病毒感染与过敏性炎症相互作用,从而导致下呼吸道功能障碍、喘息和哮喘。首先,潜在的过敏性炎症可以直接增强气道对鼻病毒感染的反应性。此外,病毒感染可损害气道上皮的屏障功能,导致气道壁对气传过敏原的吸收增加和炎症反应增强,而潜在的过敏性炎症也可能导致病毒复制增强。值得注意的是,鼻病毒感染和变应原均可促进气道上皮细胞产生IL-33, IL-33是最近发现的一种先天细胞因子,可促进2型气道炎症和重塑。据报道,这种类固醇耐药途径在难以控制哮喘的儿童中上调。有趣的是,IL-33多聚物与中晚期发作的喘息有关,而中晚期发作的喘息与早期生活中的过敏反应密切相关。 另一种先天上皮细胞因子IL-25也由鼻病毒诱导,在过敏患者鼻病毒感染的情况下,IL-25可能加重过敏性气道炎症 ...
Инфламмасома - важный компонент нативного иммунитета. Она представляет собой макромолекулярный комплекс, включающий сенсорные элементы, адапторные белки и зимоген каспазы-1. Под действием продуктов распада тканей и патогенных микроорганизмов инфламмасома активируется и превращает про-IL-1b и про-IL-18 в активные интерлейкины. Активация инфламмасом отмечена при многих воспалительных заболеваниях и служит мишенью для терапевтических воздействий. В настоящем обзоре обсуждается вклад инфламмасом в патогенез социально-значимых заболеваний ...
货号产品说明规格方法学认证4300604Vialshaker(IKA Vibrax300rpm) 1pceRIAInstruments4300606Vialextraction insertforurinaryhGH1pceRIAInstrumentsKIC1261IL-6 96TIRMARUOKIC1
Description: Description of target: C-X-C motif chemokine 5 is a protein that in humans encoded by the CXCL5 gene. The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-gamma. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on humanchromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodeling. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which ...
The presence of neutrophils in the synovial joint of patients with rheumatoid arthritis (RA) is thought to be due to the activity of chemotactic factors released by activated cells in the joint. We have shown in this report, for the first time, the abundance of one such factor, interleukin 8 (IL 8), in the synovial fluid of patients both with RA and other non-RA joint diseases, and the spontaneous production of IL 8 mRNA by RA synovial cells in culture. There was no correlation between the levels of chemotactic activity and IL 8 protein, suggesting that other factors with similar neutrophil chemotactic activity are also present in the synovial fluid exudate. In support of this concept neither the level of chemotactic activity nor IL 8 protein levels correlated with neutrophil or leukocyte infiltration, indicating that the mechanism of migration into the inflammatory environment of the joint is complex. Such migration is likely to be due to a number of chemotactic signals in addition to IL 8, which may
Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene.
SEA080Hu, ELISA Kit for Interleukin 8 (IL8), Homo sapiens (Human), Sandwich ELISA, CXCL8, AMCF-I, GCP1, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP1, SCYB8, TSG1, B-ENAP, Neutrophil-Activating Protein 1, Granulocyte Chemotactic Protein 1, Designed by Cloud-Clone Corp.
In this series of experiments we have demonstrated that the stimulated release of IL-6 and IL-8 from cultures obtained from controls and smokers without airflow obstruction is amplified by 5% CSE pretreatment, but this was not apparent in the COPD group. Our results also show cellular immunosuppressive effects of 5% CSE in the COPD cultures. These findings suggest that COPD PBECs are more susceptible to the immunosuppressive effects of CSE which may explain, in part, the increased susceptibility of this particular group to respiratory infections.. In our experiments, 5% CSE reduced the expression of TLR-4. Similar findings were recently reported using a human bronchial epithelial cell line, where CSE treatment led to a downregulation of TLR-4 expression, which was associated with a corresponding increase in the release of IL-8. Internalisation of the receptor was proposed as the mechanism, as there was a parallel increase in the expression of TLR-4 in permeabilised cells [4]. However, the ...
An all-on-chip method enables rapid neutrophil chemotaxis assay directly from a few microliters of blood for both cell migration research and clinical sample test.
Gentaur molecular products has all kinds of products like :search , SeraLab \ Human Whole Blood EDTA K2 Male Individual Donor, not Filtered \ BK2IM-114-V for more molecular products just contact us
Gentaur molecular products has all kinds of products like :search , SeraLab \ Human Whole Blood EDTA K2 Individual Donor, not Filtered \ BK2I-123-F for more molecular products just contact us
IL-12/IL-23 p40, Functional Grade, clone: C8.6, eBioscience™ 500μg; Functional Grade IL-12/IL-23 p40, Functional Grade, clone: C8.6, eBioscience™...
IL-12/IL-23 p40, PerCP-Cyanine5.5, clone: C17.8, eBioscience™ 25μg; PerCP-Cyanine5.5 IL-12/IL-23 p40, PerCP-Cyanine5.5, clone: C17.8, eBioscience™...
Interleukin 5), promote adaptive and allergic immune responses (viz., Interleukin 4), promote allergic responses and tissue ... interleukin 5 and annexin A1). DRESS syndrome: Key elements promoting tissue injury in the DRESS syndrome are: Th2 cells and ... Interleukin 22); and a cytokine which promotes the function of neutrophils, other granulocyte types, and monocytes as well as ... Interleukin 8 and Interleukin 17); a promoter of innate immune and autoimmune responses (viz., ...
Waugh DJ, Wilson C (November 2008). "The interleukin-8 pathway in cancer". Clinical Cancer Research. 14 (21): 6735-41. doi: ... They migrate through the blood vessels and then through interstitial tissue, following chemical signals such as Interleukin-8 ( ... Neutrophils have a variety of specific receptors, including ones for complement, cytokines like interleukins and IFN-γ, ... Cell surface receptors allow neutrophils to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon ...
... interleukin-6, interleukin-8, and GM-CSF. These activities are G2A-dependent. It is suggested that 9-HODE acts in human skin to ... interleukin-6 and keratinocyte chemoattractant, in in vivo studies. G2A is also involved in blood-borne lysophosphatidylcholine ... 178 (10): 6540-8. doi:10.4049/jimmunol.178.10.6540. PMID 17475884. Yan JJ, Jung JS, Lee JE, Lee J, Huh SO, Kim HS, Jung KC, Cho ... 8-HETE, 9-HETE, and 11-HETE stimulate Chinese hamster ovary cells made to express G2A; these effects, unlike those of ...
October 1994). "Histamine induces interleukin-8 secretion by endothelial cells". Blood. 84 (7): 2229-2233. doi:10.1182/blood. ... the C314T variant also showed an association with serum Interleukin-8 (IL-8) levels - individuals with the CT or TT genotype ... Although the relationship between histamine and IL-8 has not been fully studied as of 2020[update], it is known that histamine ... had lower levels of IL-8 (1.2 ± 0.7 versus 2.1) and higher levels of histamine (107.0 ± 53.9 versus 85.6 ± 45.7 ng/mL) in ...
Interleukin-8 plays a role in rheumatoid arthritis. Protease secretion: Blastocystis secretes a protease that breaks up ... Blastocystis has been shown to provoke cells from the human colon to produce inflammatory cytokines interleukin-8 and GM-CSF. ... 39 (4): 734-8. doi:10.1128/AEM.39.4.734-738.1980. PMC 291411. PMID 7377773. Li LH; Zhou XN; Du ZW; Wang XZ; Wang LB; Jiang JY; ... 46 (8): 178-9. PMID 8936976. Khalifa AM, El Temsahy MM, Abou El Naga IF (2001). "Effect of ozone on the viability of some ...
... has been shown to interact with: EYA2, GPSM2, Interleukin 8 receptor, alpha, MDFI, RGS5, and RIC8A. GRCh38: Ensembl ... Damaj BB, McColl SR, Mahana W, Crouch MF, Naccache PH (May 1996). "Physical association of Gi2alpha with interleukin-8 ... "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops ... 228 (1): 102-8. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989. Grassie MA, Milligan G (Mar 1995). "Analysis of the ...
Wu D, LaRosa GJ, Simon MI (Jul 1993). "G protein-coupled signal transduction pathways for interleukin-8". Science. 261 (5117): ... 93 (12): 6053-8. Bibcode:1996PNAS...93.6053S. doi:10.1073/pnas.93.12.6053. PMC 39187. PMID 8650218. Zhang J, Pratt RE (Jun 1996 ... 93 (26): 15203-8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. Woulfe DS, Stadel JM (Jun ... doi:10.1016/s0898-6568(02)00012-8. PMID 11955952. De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is ...
"A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor ... Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B ... 2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF- ... Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor ...
"Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor." Science (American Association for the ... 8 (1): e1364. doi:10.1002/wrna.1364. ISSN 1757-7004. PMC 5717752. PMID 27198714. Altfeld, Marcus; Jr, Michael Gale (1 June 2015 ... doi:10.1186/s12896-014-0094-8. ISSN 1472-6750. PMC 4239376. PMID 25394494. "mRNA Isolation with Dynabeads in 15 minutes - US". ...
Additionally, neutrophil apoptosis, immunoglobulin release from B-lymphocytes, and interleukin release (e.g. IL-8 and CCL5) are ... Denning G, Wollenweber L, Railsback M, Cox C, Stoll L, Britigan B (1998). "Pseudomonas pyocyanin increases interleukin-8 ...
... and published scientific articles on the localisation of gene expression for interleukin 1 receptor antagonist, interleukin 1 ... Wong, M.-L.; Bongiorno, P. B.; Rettori, V.; McCann, S. M.; Licinio, J.; Wong, M.-L. (7 January 1997). "Interleukin (IL) 1beta, ... Licinio, J.; Wong, M.-L.; Gold, P. W. (July 1991). "Localization of interleukin-1 receptor antagonist mRNA in rat brain". ... They also showed that interleukin 1 receptor antagonist is an endogenous neuroprotective agent. They have shown that the ...
May 2004). "Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring". The American Journal of ... Interleukin 8). Substantial research suggests that exposure to certain illnesses (e.g., influenza) in the mother of the neonate ... 32 (1): 3-8. doi:10.1093/schbul/sbj028. PMC 2632192. PMID 16306181. Opler, M. G.; Brown, A. S.; Graziano, J.; Desai, M.; Zheng ... 163 (3): 521-8. doi:10.1176/appi.ajp.163.3.521. PMID 16513876. Jones AL, Mowry BJ, Pender MP, Greer JM (February 2005). "Immune ...
... has a potentially similar role as interleukin-8 (IL-8/CXCL8). After binding to its receptor CXCR2, CXCL1 activates ... and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils". ... 19 (8): 2427. doi:10.3390/ijms19082427. PMC 6121631. PMID 30115896. Spaks A (April 2017). "Role of CXC group chemokines in lung ...
"Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation". Biochim. Biophys. Acta. ... 16 (7-8): 247-53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J ... 590 (8): 1270-9. doi:10.1002/1873-3468.12160. PMID 27013054. Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T ...
"Interleukin-8 and polymorphoneutrophil leucocyte activation in hemolytic uremic syndrome of childhood". Kidney International. ... 75 (8): 848-855. doi:10.1038/ki.2008.686. PMC 2813773. PMID 19165178. Fizpatrick, Margaret M.; Walters, Martin D.S.; Trompeter ... doi:10.1007/s00467-014-2805-8. ISSN 1432-198X. PMID 24682468. Levin, Michael (3 February 2014). "Martin Barratt obituary". ...
Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG (Feb 2003). "Hypertonic stress increases T cell interleukin-2 expression ... "Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway". Blood. 107 (7): 2936-42. doi: ... 222 (2): 303-8. doi:10.1006/bbrc.1996.0739. PMID 8670200. "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 ...
Zhang G, Chen R, Rudney JD (2008). "Streptococcus cristatus attenuates Fusobacterium nucleatum-induced interleukin-8 expression ...
2006). "Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo". J. Leukoc. Biol. 79 (3): 539-554. ... 175 (8): 5115-5125. doi:10.4049/jimmunol.175.8.5115. PMID 16210615. Howard, J; et al. (1998). "Molecular mimicry of the ... doi:10.1016/S0076-6879(97)88023-8. ISBN 978-0-12-182189-0. Dustin, M.L.; Chakrabortk, A.K. (2008). "Tug of war at the exit door ... 63 (8): 1969-1974. PMID 12702590. Balkwill, F (2004). "Cancer and the chemokine network". Nature Reviews Cancer. 4 (7): 540-550 ...
March 2010). "Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia". ... Several approaches have been used, including using host biomarkers such as IL-1β and IL-8. Alternatively, molecular detection ... VAP is especially common in people who have acute respiratory distress syndrome (ARDS). Between 8 and 28% of patients receiving ... 8): CD009201. doi:10.1002/14651858.CD009201.pub2. PMC 6517140. PMID 26266942. Bo L, Li J, Tao T, Bai Y, Ye X, Hotchkiss RS, et ...
Increased levels of IL-1RA, Interleukin 6 and Interleukin 8 have been found. Neurogenic inflammation has been proposed as a ... 9 (8): 730-1. doi:10.1038/ PMID 15052273. S2CID 31226142. Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu ... 8 (6): 425-9. doi:10.1007/s11926-006-0036-0. PMID 17092441. S2CID 27103590. Leavitt F, Katz RS, Mills M, Heard AR (April 2002 ... 8 (5): 364-8. doi:10.1007/s11916-996-0009-z. PMID 15361320. S2CID 34122137. Moldofsky H, Scarisbrick P, England R, Smythe H ( ...
"Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8". Nature. 365 (6447): 654-7. ... 27 (4): 1063-8. PMID 10782838. Digiovanni, CW; Patel, A; Calfee, R; Nickisch, F (2007). "Osteonecrosis in the foot" (PDF). The ... 64 (2): 182-8. PMID 9486895. Grigoriadis, E; Fam, AG; Starok, M; Ang, LC (2000). "Skeletal muscle infarction in diabetes ... 8 (11): 1907-1916. doi:10.1517/13543784.8.11.1907. PMID 11139833. Ropper, Allan H.; Adams, Raymond Delacy; Brown, Robert F.; ...
"Interleukin (IL)-8 levels were significantly higher in XL-CGD carriers (mean 1459u/ml) than in healthy controls (mean 72u/ml) ( ... "Interleukin (IL)-8 levels were significantly higher in XL-CGD carriers (mean 1459u/ml) than in healthy controls (mean 72u/ml) ( ... Interleukin 8 (IL-8): Associeret med massiv træthed hos bærere af den X-bunde type.[28] ... p=0.015) and patients with Sjögren's syndrome (mean 203u/ml) (p=0.031) (Figure 1). IL-8 levels were also significantly higher ...
"Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants". Nature Medicine. 20 (10): ...
Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR ... Chang YH, Hsieh SL, Chen MC, Lin WW (2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and ... Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF- ... 16 (1): 214-8. doi:10.1006/geno.1993.1161. PMID 8486360. Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, ...
... arginase 2 and interleukin-8 in human prostate cancer". PLOS ONE. 5 (8): e12107. Bibcode:2010PLoSO...512107G. doi:10.1371/ ... 28 (2-3): 133-8. doi:10.1016/j.placenta.2006.03.015. PMID 16720041. This article incorporates text from the United States ... "IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer". International Journal of ...
Hedvat CV, Yao J, Sokolic RA, Nimer SD (February 2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 ... 30 (8): 1037-42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180. Lu Z, Kim KA, Suico MA, Shuto T, Li JD, Kai H (March 2004 ... 279 (8): 6395-400. doi:10.1074/jbc.M307524200. PMID 14625302. Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, ... 279 (18): 19091-8. doi:10.1074/jbc.M312439200. PMID 14976184. Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P ...
Wang X, Wang Q, Ives KL, Evers BM (September 2006). "Curcumin inhibits neurotensin-mediated interleukin-8 production and ... 290 (4): 1161-8. doi:10.1006/bbrc.2001.6308. PMID 11811984. Carraway R, Leeman SE (1975). "The amino acid sequence of a ... doi:10.1016/S0021-9258(19)41780-8. PMID 1167549. Dobner PR, Barber DL, Villa-Komaroff L, McKiernan C (1987). "Cloning and ...
"Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8". ... 69 (8): 3347-55. doi:10.1158/0008-5472.CAN-08-3821. PMC 2669850. PMID 19351840. Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, ...
... caused the inhibition of recombinant interleukin-8 (IL-8) induced migration of the inflammatory cells. Two other pro- ... 10 (1): 154-8. doi:10.1089/jmf.2006.262. PMID 17472480. Laine L, Takeuchi K, Tarnawski A (2008). "Gastric mucosal defense and ... doi:10.1007/4-431-27174-0_8. ISBN 4-431-22135-2. Kusugami K, Ina K, Hosokawa T, Kobayashi F, Kusajima H, Momo K, Nishio Y (May ... 84 (1): 11-8. doi:10.1254/fpj.84.11. PMID 6489865. Prescribing information of APLACE (Troxipide). 2008. Kyorin Pharmaceutical ...
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.. Science. 2000, ... 人類所擁有的調控序列所在位置,可以利用河豚的基因定位出來。因為河豚與人類擁有相同的基因,同時也擁有和人類相同的調控序列,但是「垃圾」基因比
Instead, plasma cells are identified through flow cytometry by their additional expression of CD138, CD78, the Interleukin-6 ...
Interleukin-10 determines viral clearance or persistence in vivo. Nature Medicine. November 2006, 12 (11): 1301-9. PMC 2535582 ... Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. The Indian Journal of ... August 2011, 13 (8-9): 742-8. PMC 3130845. PMID 21458588. doi:10.1016/j.micinf.2011.03.007.. ... Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2. JCI insight. 2017-08-17, ...
EPO " Interleukin " G-CSF " OM " LIF " IFN " CD " TNF-α " LT " Ligand " TGF " MIF ... C5a " CCL2 " CCL5 " GSM-CSF " LPS " MCP-1 " IL-1 " IL-2 " IL-3 " IL-4 " IL-5 " IL-6 " IL-8 " IL-10 " IL-12 " IL-13 " IL-15 " IL ...
... the Antigen-Presenting Cell causes a response in a TH2 lymphocyte which produce the cytokine interleukin-4 (IL-4). The TH2 ... doi:10.1016/S0022-3476(05)81408-8. PMID 1447635. *^ De Swert LF (1999). "Risk factors for allergy". Eur. J. Pediatr. 158 (2): ... 8] Often, people suffering from temporal lobe epilepsy report symptoms of negative effects such as anxiety and depression that ...
CXCL10, hemokin (C-X-C motiv) ligand 10, ili IP-10[1] je mali citokin iz CXC hemokin familije koji je takođe poznat kao 10 kDa interferon-gama-inducirani protein (γ-IP10 ili IP-10). CXCL10 luči nekoliko ćelijski tipova u responsu na IFN-γ. U te ćelijske tipove spadaju monociti, endotelijalne ćelije i fibroblasti.[2] CXCL10 hemokinu je bilo pripisano nekoliko uloga, kao što su hemoatrakcija monocita/makrofaga, T ćelija, NK ćelija, i dendritskih ćelija, promocija adhezije T ćelija na endotelijalne ćelije, antitumorska aktivnost, i inhibicija formiranja kolonija kičmene moždine i angiogeneze.[3][4] CXCL10 gen je lociran na ljudskom hromozomu 4 u klasteru sa nekoliko drugih CXC hemokina.[5] Ovaj hemokin dejstvuje putem vezivanja na CXCR3 hemokin receptore na ćelijskoj površini.[6]. Tri-dimenzionalna kristalna struktura ovog hemokina je bila utvrđena u 3 različite grupe uslova u rezoluciji do 1.92 A.[7] PDB pristupni kodovi za CXCL10 strukture su: 1lv9, 1o7y, 1o7z i 1o80.[8] ...
positive regulation of interleukin-4 production. • oocyte development. • positive regulation of type IV hypersensitivity. • ... 74 (4): 760-8. doi:10.1095/biolreprod.105.047522. PMID 16407501.. *. Chamberlin ME, Dean J (1990). "Human homolog of the mouse ... 28 (3): 381-8. doi:10.2164/jandrol.106.001289. PMID 17192598.. *. Qi H, Williams Z, Wassarman PM (2002). "Secretion and ... 87 (16): 6014-8. Bibcode:1990PNAS...87.6014C. doi:10.1073/pnas.87.16.6014. PMC 54462. PMID 2385582.. ...
Stimulation of interleukin-2 production by substance p". Journal of Neuroimmunology. 37 (1-2): 65-74. doi:10.1016/0165-5728(92) ... doi:10.1016/S0079-6123(06)61007-8. PMID 17618972.. *^ De Felipe C, Herrero JF, O'Brien JA, Palmer JA, Doyle CA, Smith AJ, Laird ... 4 (1): 42-8. PMID 9326744.. *^ Geracioti TD, Carpenter LL, Owens MJ, Baker DG, Ekhator NN, Horn PS, Strawn JR, Sanacora G, ... The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).[8] It belongs to the tachykinin receptor ...
The release of proinflammatory cytokines such as interleukin-1 by activated leukocytes triggered by lipopolysaccharides, ... Maier SF, Wiertelak EP, Martin D, Watkins LR (October 1993). "Interleukin-1 mediates the behavioral hyperalgesia produced by ... 33 (8): 1952-65. doi:10.1038/sj.npp.1301590. PMID 17957217.. *^ Koppert W, Wehrfritz A, Körber N, et al. (March 2004). "The ... 8 (1): 51-7. doi:10.2165/00126839-200708010-00005. PMID 17249849.. *^ Vorobeychik Y, Chen L, Bush MC, Mao J (September 2008). " ...
Interleukins/T-cell growth factors (see here instead). *Leukemia inhibitory factor (LIF) ... doi:10.1016/s1470-2045(14)71173-8. PMID 25589191.. *^ Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Jangchul P, Kondo C, et al ... It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ...
Za B-ćelijski aktivirajući faktor je bilo pokazano da interaguje sa TNFRSF13B,[7][8] TNFSF13[9] i TNFRSF17.[10][11] ... 1-8. PMID 17346422. CS1 održavanje: Eksplicitna upotreba et al. (link) ... 8): 4314-21. PMID 12370363. Cite uses deprecated parameter ,month=. (help) ...
... , hemokin (C-X-C motiv) ligand 16, je mali citokin iz CXC hemokin familije. On je veći od drugih hemokina (sadrži 254 aminokiselina). CXCL16 se sastoji od CXC hemokin domaina, mucinu-slične stabljike, transmembranskog domaina i citoplazmatičnog repa koji sadrži potentno mesto tirozin fosforilacije koje može da veže SH2.[1] Ovo su neuobičajene osobine za hemokin, i omobućavaju CXCL16 da bude izražen kao molekul na ćelijskoj površini, kao i rastvorni hemokin.[2] CXCL16 proizvode dendritiske ćelije koje se mogu naći u T ćelijskim zonama limfoidnih organa, i ćelije iz crvene pulpe slezine.[1] Među ćelijama koje se vezuju i migriraju u responsu na CXCL16 su nekoliko podgrupa T ćelija, i NKT ćelije.[1] CXCL16 interaguje sa hemokin receptorom CXCR6, takođe poznatim kao Bonzo.[3][1] Ekspresiju CXCL16 indukuju inflamatorni citokini IFN-gama i TNF-alfa.[2] Gen za ljudski CXCL16 je lociran na hromozomu 17.[1][4] ...
... associations and interaction with the interleukin-1alpha-889 C/T polymorphism". Hum. Immunol. 65 (6): 622-31. doi:10.1016/j. ... 8 (6): 925-30. PMID 6977032.. *^ Price P, Santoso L, Mastaglia F, et al. (November 2004). "Two major histocompatibility complex ... The "HL-A1,8 phenotype" was found to be associated with severe systemic lupus erythematosus (SLE) (renal and central nervous ... In 1975, association with "HL-A1,8" (Current name: HLA A1-B8) was confirmed by serological typing of cells from myasthenics.[11 ...
Theorell, T.; Hasselhorn, H.; Vingård, E.; Andersson, B. (2000). "Interleukin 6 and cortisol in acute musculoskeletal disorders ... 8] *^ Social Security Administration. (2012). Annual statistical report on the Social Security Disability Insurance Program, ... Work & Stress, 8, 130-140. doi: 10.1080/02678379408259985 *^ Siegrist, J. (1996). Adverse health effects of high-effort/low- ... Newsletter of the Society for Occupational Health Psychology, 9, 8-9. [15] ...
Borges W, Augustine N, Hill H (2000). "Defective interleukin-12/interferon-gamma pathway in patients with ...
Kullberg, Bart Jan; Arendrup, Maiken C. (8 October 2015). "Invasive Candidiasis". The New England Journal of Medicine. 373 (15 ... 182 (7-8): 701-708. doi:10.1007/s11046-017-0132-x. ISSN 1573-0832. PMID 28378239. S2CID 3870306.. ...
"Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer". International ... 27 (8): 844-50. doi:10.3109/14767058.2013.837879. PMID 23981182.. *^ Zhang Y, Fan M, Geng G, Liu B, Huang Z, Luo H, Zhou J, Guo ... 35 (5): 601-8. doi:10.1002/humu.22535. PMID 24616209.. *^ Žaja O, Tiljak MK, Štefanović M, Tumbri J, Jurčić Z (May 2014). " ... The Pribnow box has a 6 bp region centered around the -10 position and an 8-12 bp sequence around the -35 region that are both ...
... interleukin-5)可促進嗜曙紅顆粒白血球成長及分化。[13] ... 長期以來人們已經認識到人類嗜中性顆粒白血球細胞內顆粒體具有蛋白質降解能力並可殺菌。[8]嗜中性顆粒白
... and interleukin-1 in modulating progesterone and oestradiol production by human luteinized granulosa cells in culture. Hum. ... 多囊性卵巢會受基因遺傳與環境因素影響[6][7]。其危險因子包含肥胖症、運動量不足或是有家族病史[8]。如果有以下三種症狀中的兩種便可診斷患者有多囊性卵巢:無排卵、雄性激素過高與卵巢囊腫[4]。囊腫可以由超音波影像檢測。其他造成類似症狀的疾病包含先
negative regulation of interleukin-6 secretion. • negative regulation of neuron death. • negative regulation of matrix ... Shiratori I., Yamaguchi M., Suzukawa M. et al. Down-regulation of basophil function by human CD200 and human herpesvirus-8 ...
Interleukins/T-cell growth factors (see here instead). *Leukemia inhibitory factor (LIF) ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ... 11 (8): 1169-80. doi:10.1017/S1461145708009309. PMID 18752720.. *^ Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL, Chen DC ... 8: 170. doi:10.3389/fncel.2014.00170. PMC 4064707. PMID 24999318.. *^ Heinonen I, Kalliokoski KK, Hannukainen JC, Duncker DJ, ...
An example of an autocrine agent is the cytokine interleukin-1 in monocytes. When interleukin-1 is produced in response to ... Interleukin 6 ACRONYM (IL-6) is a cytokine that is important for many aspects of cellular biology including immune responses, ... 8 (3): 197-204. doi:10.1007/s10456-005-9010-0. PMID 16328160. Mercurio, Arthur M; Bachelder, Robin E; Bates, Richard C; Chung, ... the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis. Recent studies ...
2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 ... Interleukin 8 receptor, beta. Reference[uredi - уреди , uredi izvor]. *↑ Wolff B, Burns AR, Middleton J, Rot A (November 1998 ... vezivanje za interleukin-8 receptor. • vezivanje za proteine. • aktivnost hemokina. Ćelijska komponenta. • ekstracelularni ... Interleukin 8 (IL-8) je citokin koga proizvode makrofage i ćelije drugih tipova kao što su epitelijalne ćelije. NJega isto tako ...
Rattazzi M, Puato M, Faggin E, et al. (2004). C-reactive protein and interleukin-6 in vascular disease: culprits or passive ... Mastorakos G, Ilias I (2007). Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress. Ann. N. Y. ... Nishimoto N (May 2006). Interleukin-6 in rheumatoid arthritis. Curr Opin Rheumatol 18 (3): 277-81. PMID: 16582692. DOI: 10.1097 ... Smith PC, Hobisch A, Lin DL, Culig Z, Keller ET (March 2001). Interleukin-6 and prostate cancer progression. Cytokine Growth ...
4,0 4,1 4,2 4,3 4,4 4,5 4,6 Kolls JK, Lindén A (2004). "Interleukin-17 family members and inflammation". Immunity 21 (4): 467- ... "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17". J. Biol. ... Interleukin 17 (IL-17, ili IL-17A) je osnivački član grupe citokina poznatih kao IL-17 familija. IL-17A, je originalno (1993. ... 17,0 17,1 17,2 17,3 Moseley TA, Haudenschild DR, Rose L, Reddi AH (2003). "Interleukin-17 family and IL-17 receptors". Cytokine ...
Interleukin receptors *IL2R / IL2RA/IL2RB / IL15R. *IL4R / IL13R / IL13RA1 / IL13RA2. *IL7R / IL7RA ... 8: 139. doi:10.3389/fonc.2018.00139. PMC 5937056. PMID 29761078.. *^ a b Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K ... "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".. *^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL ( ... 93 (24): 14053-8. doi:10.1073/pnas.93.24.14053. PMC 19493. PMID 8943059.. (Retracted. If this is an intentional citation to a ...
Interleukins/T-cell growth factors (see here instead). *Leukemia inhibitory factor (LIF) ...
Singh B, Schwartz JA, Sandrock C, Bellemore SM, Nikoopour E (2013). „Modulation of autoimmune diseases by interleukin (IL)-17 ... 140 (7): 2171-8. PMID 2965180.. *^ Willinger T, Freeman T, Hasegawa H, McMichael AJ, Callan MF (2005). „Molecular signatures ... Ova dva podskupa su ranije bila nazivana "prirodni" i "adaptivni" ili "indukovani".[8] Za oba podskupa je neophodno izražavanje ...
Interleukins/T-cell growth factors (see here instead). *Leukemia inhibitory factor (LIF) ... 28A (2): 102-8. doi:10.1007/BF02631013. PMID 1537750.. *^ "Researchers make older beta cells act young again". ... Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ...
cellular response to interleukin-4. • cellular response to phorbol 13-acetate 12-myristate. • cellular response to ionomycin. • ... 8 (24): 2939-52. doi:10.1101/gad.8.24.2939. PMID 8001816.. *^ Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ, Timchenko ... 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.. *^ Ghavidel A, Cagney G, Emili A (2005). "A skeleton of the human ... 8 (24): 2939-52. doi:10.1101/gad.8.24.2939. PMID 8001816.. *. Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). "Regulation of ...
"Entrez Gene: IL8RA interleukin 8 receptor, alpha".. *^ Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, ... Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by ... interleukin-8 receptor activity. • signal transducer activity. Cellular component. • integral component of membrane. • plasma ... interleukin-8 binding. • G-protein coupled receptor activity. • chemokine receptor activity. • ...
Interleukin-8 and related CXC chemokines are involved in the function of neutrophils and T cells, and have been implicated in ... Interleukin-8 receptor antagonists in pulmonary diseases.. Hay DW1, Sarau HM. ... Small-molecule antagonists of the interleukin-8 receptors have been identified, which may help elucidate the role of ...
... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw ... Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types ... In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 ... Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil ...
Interleukin-8 and its receptor CXCR2 in atherosclerosis.. Boisvert WA1, Curtiss LK, Terkeltaub RA. ... interleukin-8 (KC/growth-related oncogene alpha in mice) and its receptor CXCR2 has not been studied in the pathogenesis of ...
USA Home > Product Directory > Cell Culture > Reagents and Supplements > Growth Factors and Cytokines > Interleukins (IL) > ... Interleukin-8 human ≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, cell culture tested * ... IL-8 (77aa) (CXCL8) human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested * pricing ... IL-8 (72AA) human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) * pricing ...
Binding of Interleukin 8 leads to activation of the cell (commonly a neutrophil), allowing it to recruit more white blood cells ... The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: interleukin-8 ... IL-8RA is highly specific for interleukin-8 and only responds when this particular ligand is bound to its receptor site, ... Brat, Daniel J.; Bellail, Anita C.; Van Meir, Erwin G. (2017-05-25). "The role of interleukin-8 and its receptors in ...
C5a · CCL2 · CCL5 · GSM-CSF · LPS · MCP-1 · IL-1 · IL-2 · IL-3 · IL-4 · IL-5 · IL-6 · IL-8 · IL-10 · IL-12 · IL-13 · IL-15 · IL ... EPO · Interleukin · G-CSF · OM · LIF · IFN · CD · TNF-α · LT · Ligand · TGF · MIF ... Interleukin-8, IL-8 adalah hormon golongan kemokina berupa polipeptida dengan massa sekitar 8-10 kDa yang digunakan untuk ... IL-8 diproduksi oleh berbagai macam sel, termasuk monosit, neutrofil, sel T, fibroblas, sel endotelial dan sel epitelial, ...
2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 ... Interleukin 8 receptor, beta. Reference[uredi - уреди , uredi izvor]. *↑ Wolff B, Burns AR, Middleton J, Rot A (November 1998 ... vezivanje za interleukin-8 receptor. • vezivanje za proteine. • aktivnost hemokina. Ćelijska komponenta. • ekstracelularni ... Interleukin 8 (IL-8) je citokin koga proizvode makrofage i ćelije drugih tipova kao što su epitelijalne ćelije. NJega isto tako ...
Pharmacological Actions : Interleukin-1 receptor antagonist, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor ... Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF- ... Pharmacological Actions : Interleukin-10 upregulation, Interleukin-4 downregulation, Interleukin-8 downregulation, Tumor ... Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Interleukin-8 ...
INTERLEUKIN-8. A, B. 72. Homo sapiens. Mutation(s): 0 Gene Names: POTENTIAL, CXCL8, IL8. ... Three-dimensional structure of interleukin 8 in solution.. Clore, G.M., Appella, E., Yamada, M., Matsushima, K., Gronenborn, A. ... The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and ... The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and ...
We investigated the role of interleukin 8 (IL-8) in the pathogenesis of proliferative vitreoretinopathy (PVR). The IL-8 level ... Role of interleukin 8 in the pathogenesis of proliferative vitreoretinopathy Ophthalmologica. 1997;211(4):223-5. doi: 10.1159/ ... We investigated the role of interleukin 8 (IL-8) in the pathogenesis of proliferative vitreoretinopathy (PVR). The IL-8 level ... The IL-8 level in the vitreous was between 31.3 and 65 pg/ml in 40% of eyes with PVR. IL-8 was detected neither in the blood of ...
Interleukin 8 receptor, betaImported. ,p>Information which has been imported from another database using automatic procedures ... cDNA FLJ78215, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNAImported. ,p>Information which has been ... cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNAImported. ,p>Information which has been imported from ... tr,Q53PC4,Q53PC4_HUMAN Interleukin 8 receptor, beta OS=Homo sapiens GN=IL8RB PE=2 SV=1 ...
AIM: To characterize the role of IL-8 in the contraction of rat intestinal segments ... IL-8) is a pro-inflammatory cytokine highly expressed in inflammatory bowel diseases, but whose effects on intestinal motility ... Interleukin-8 / administration & dosage, physiology*. Intestines / drug effects*, metabolism. Male. Muscle Contraction / drug ... BACKGROUND: Interleukin-8 (IL-8) is a pro-inflammatory cytokine highly expressed in inflammatory bowel diseases, but whose ...
Interleukin-8/CXCL8 (IL-8) is a chemokine and angiogenic factor. Recently, IL-8 was identified as an autocrine growth factor in ... Here, we investigated the expression and function of IL-8 in lung cancer cells. The expressions of IL-8 and its receptors, ... Interleukin-8/CXCL8 is a growth factor for human lung cancer cells Br J Cancer. 2004 Nov 29;91(11):1970-6. doi: 10.1038/sj.bjc. ... Interleukin-8/CXCL8 (IL-8) is a chemokine and angiogenic factor. Recently, IL-8 was identified as an autocrine growth factor in ...
Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.. D R Smith, P J Polverini, S L Kunkel, M B ... Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.. D R Smith, P J Polverini, S L Kunkel, M B ... We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased ... It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific ...
K. Xie, "Interleukin-8 and human cancer biology," Cytokine and Growth Factor Reviews, vol. 12, no. 4, pp. 375-391, 2001. View ... granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients ... C. A. Dinarello, "Interleukin-1 and its biologically related cytokines," Advances in Immunology, vol. 44, pp. 153-205, 1989. ... J. E. De Larco, B. R.K. Wuertz, K. A. Rosner et al., "A potential role for interleukin-8 in the metastatic phenotype of breast ...
Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.. H G Folkesson, M A Matthay, ... Neutralization of IL-8 may provide the first useful therapy for this clinically important form of acute lung injury. ... The anti-IL-8 monoclonal antibody also significantly reduced air space neutrophil counts and IL-8 concentrations. This study ... The rabbits were studied for 6 or 24 h. In acid-instilled rabbits without the anti-IL-8 monoclonal antibody, severe lung injury ...
"Receptors, Interleukin-8" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and ... This graph shows the total number of publications written about "Receptors, Interleukin-8" by people in Harvard Catalyst ... Below are the most recent publications written about "Receptors, Interleukin-8" by people in Profiles. ...
Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 ... Structure and functional expression of a human interleukin-8 receptor Message Subject. (Your Name) has forwarded a page to you ... The IL-8 receptor may be part of a subfamily of related G protein-coupled receptors that transduce signals for the IL-8 family ... Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by ...
Interleukin 8 promotes chemotaxis in target cells. It is also responsible for the mobility of these cells towards the site of ... Interleukin are responsible for the immune response, which has lead to the conclusion that well-functioning Interleukins are an ... About Interleukin-8:. Mechanism interleukin 8 is sometimes called CXCL8. It is a chemokine that is produced by a variety of ... Interleukin 8 is believed to have a contributory role in regards to colorectal cancer. It acts as an autocrine growth factor ...
... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion , journal = Eur. ... Infobox_gene}} Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a [[chemokine]] produced by ... pages 122-133">{{cite journal , author = Brat DJ, Bellail AC, Van Meir EG , year = 2005 , title = The role of interleukin-8 and ... See also == * [[IL8RA,Interleukin 8 receptor, alpha]] * [[IL8RB,Interleukin 8 receptor, beta]] {{Clear}} == References == {{ ...
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. J Biol Chem 1996;271: ... Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro. Cytokine 2000;12:78-85. ... Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells. Int J Cancer 2007;121:1949- ... Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer. Cancer Res 2007;67:6854- ...
Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 is reported to suppress ... Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity. Immunology Letters 19: 183-191. ... Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4+ T cells. PeerJ 5: e2999.CrossRefPubMed ... Interleukin-35 gene therapy exacerbates experimental rheumatoid arthritis in mice. Cytokine 69: 87-93.CrossRefPubMedGoogle ...
Interleukin-8 (IL-8), also known as neutrophil chemotactic factor, belongs to the CXC chemokine family and mainly serves as an ... References & Salivary Interleukin-8 Research. *Bickel M. (1993). The role of interleukin-8 in inflammation and mechanisms of ... 1999). Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for ... Baggiolini M, Clark-Lewis I. (1992). Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett. 307(1):97-101. ...
Interleukin-8 as a macrophage-derived mediator of angiogenesis. By AE Koch, PJ Polverini, SL Kunkel, LA Harlow, LA DiPietro, VM ... Interleukin-8 as a macrophage-derived mediator of angiogenesis. By AE Koch, PJ Polverini, SL Kunkel, LA Harlow, LA DiPietro, VM ... Interleukin-8 as a macrophage-derived mediator of angiogenesis Message Subject. (Your Name) has forwarded a page to you from ... The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, ...
Interleukin-8 / biosynthesis*, secretion*. Isocyanates / pharmacology*. Mitogen-Activated Protein Kinase 1 / biosynthesis. ... Exposure of BEAS-2B cells and HBECs to IPDI increased interleukin (IL)-8 production. Culture of BSMCs with IPDI-BEAS-2B-CM and ... 0/Enzyme Inhibitors; 0/Interleukin-8; 0/Isocyanates; 0/RNA, Small Interfering; 43B0856528/isophorone diisocyanate; EC ... FAK and ERK1/2 inhibitor also decreased IPDI-BEAS-2B-CM-, IPDI-HBEC-CM- and recombinant human IL-8-mediated BSMC proliferation ...
Interleukin 8 ELISA Kit Human für Cell Culture Supernatant, Cell Lysate. Publiziert in 13 Pubmed Referenzen. , Interleukin 8 ... Interleukin 8 ELISA Kit (IL8) Interleukin 8 ELISA Kit (IL8). Details for Product IL8 ELISA Kit No. ABIN414887, Anbieter: ... Produktdetails Interleukin 8 ELISA Kit Referenzen Bilder Handhabung Anwendungsinformationen Antigendetails zurück nach oben ... Referenzen für Interleukin 8 Kit (ABIN414887) Bilder Handhabung Anwendungsinformationen Antigendetails zurück nach oben ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Cui HS, Hayasaka S, Zhang XY, Hayasaka Y, Chi ZL, Zheng LS (2006) Effect of berberine on interleukin-8 and monocyte chemotactic ... Cui HS, Hayasaka S, Zhang XY, Chi ZL, Hayasaka Y (2005) Effects of α-melanocyte-stimulating hormone on interleukin-8 and ... Aksunger A, Or M, Okur H, Hasanreisoglu B, Akbatur H (1997) Role of interleukin 8 in the pathogenesis of proliferative ... Baggiolini M, Dewald B, Moser B (1994) Interleukin-8 and related chemotactic cytokines-CXC and CC Chemokines. Adv Immunol 55:97 ...
Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma. Dan Huang, Yan Ding, Ming Zhou, ... Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells. Nat Med 2005;11:992-7. ... The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005;7:122-33. ... Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic ...
  • Small-molecule antagonists of the interleukin-8 receptors have been identified, which may help elucidate the role of interleukin-8 and related chemokines in the pathophysiology of lung diseases. (
  • IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response and has been demonstrated to be a signatory chemokine of CR2+ naive T cells also known as recent thymic emigrants). (
  • Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. (
  • The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB). (
  • Receptors A and B share 78% of their sequence identity, and are considered to be the only two biologically significant receptors of IL-8. (
  • The N-terminus of both receptors A and B are rich in acidic residues, which correlate to their high binding affinities for IL-8, which is rich in basic residues. (
  • The expressions of IL-8 and its receptors, CXCR1 and CXCR2, were examined in a panel of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cell lines. (
  • We next investigated whether IL-8 could act as an autocrine growth factor in two NSCLC cell lines (H460 and MOR/P) expressing both IL-8 and its receptors. (
  • C. Schumacher, I. Clark-Lewis, M. Baggiolini, and B. Moser, "High- and low-affinity binding of GRO α and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils," Proceedings of the National Academy of Sciences of the United States of America , vol. 89, no. 21, pp. 10542-10546, 1992. (
  • Receptors, Interleukin-8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • Cell surface receptors that are specific for INTERLEUKIN-8. (
  • This graph shows the total number of publications written about "Receptors, Interleukin-8" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Interleukin-8" was a major or minor topic of these publication. (
  • Below are the most recent publications written about "Receptors, Interleukin-8" by people in Profiles. (
  • The IL-8 receptor may be part of a subfamily of related G protein-coupled receptors that transduce signals for the IL-8 family of pro-inflammatory cytokines. (
  • IL-8 can be secreted by any cell that features toll-like receptors and are involved in the human response. (
  • Increased expression of IL-8 and/or its receptors has been characterized in cancer cells, endothelial cells, infiltrating neutrophils, and tumor-associated macrophages, suggesting that IL-8 may function as a significant regulatory factor within the tumor microenvironment. (
  • The biological effects of IL-8 are mediated through the binding of IL-8 to two cell-surface G protein-coupled receptors, termed CXCR1 and CXCR2 ( 2 , 3 ). (
  • Certain IL-8-promoted responses are insensitive to pertussis-toxin, however, suggesting that these receptors may couple to and activate other as yet uncharacterized Gα proteins ( 6 ). (
  • CXCR1 receptors are activated only in response to binding of IL-8 and granulocyte chemotactic protein-2. (
  • Signalling through CXCR1/2 G-protein-coupled-receptors (GPCRs), the interleukin (IL)-8 receptors, is critical for the recruitment and activation of neutrophils. (
  • The P2Y6-specific antagonist, MRS2578, led to a significant but partial decrease in IL-8 expression, suggesting that P2 receptors in addition to P2Y6 are involved in the HNP-1-induced production of IL-8 by Caco-2 cells. (
  • In conclusion, our data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells. (
  • To determine whether IL-8 can act in an autocrine manner to regulate the expression of other disease-progression genes, we examined the expression of IL-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) in six different human gastric carcinoma cell lines and 38 surgical specimens of human gastric carcinomas. (
  • Collectively, these results demonstrate that human gastric carcinoma cells express receptors for IL-8 and that IL-8 may play a role in the progressive growth of human gastric carcinoma by autocrine/paracrine mechanisms. (
  • IHC analyses revealed that both IL-8 receptors are expressed on the surface of human carcinoma cells (17 , 18) , but the role of these receptors in cancer progression remains unknown. (
  • Objective- Interleukin-8 (IL-8) receptors IL8RA and IL8RB (IL8RA/B) on neutrophil membranes bind to IL-8 with high affinity and play a critical role in neutrophil recruitment to sites of injury and inflammation. (
  • Human IL-8 receptors are members of a family of G protein-coupled receptors and are abundantly expressed on neutrophils, the primary target for CXC chemokines. (
  • Stimulation of A 2B but not A 2A receptors induced production of interleukin-8 (IL-8) from HMC-1 cells. (
  • In addition to its angiogenic effects, IL-8 receptors (CXCR1 and CXCR2) are expressed on lung cancer cells and IL-8 can act as growth/survival factor to these cells [ 12 ]. (
  • BACKGROUND: Interleukin-8 (IL-8) is a pro-inflammatory cytokine highly expressed in inflammatory bowel diseases, but whose effects on intestinal motility are unknown. (
  • J. M. Schröder, "The neutrophil-activating peptide 1/interleukin 8, a novel neutrophil chemotactic cytokine," Archivum Immunologiae et Therapia Experimentalis , vol. 40, pp. 23-31, 1992. (
  • We hypothesized that a major acid-induced cytokine was IL-8 and that a neutralizing anti-rabbit-IL-8 monoclonal antibody (ARIL8.2) would attenuate acid-induced lung injury in rabbits. (
  • This study establishes IL-8 as a critical cytokine for the development of acid-induced lung injury. (
  • Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. (
  • The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, is also angiogenic. (
  • Interleukin (IL)-8 is an inflammatory cytokine belonging to the CXC chemokine family that is produced by a wide range of cells, including lymphocytes, monocytes/macrophages, neutrophils, fibroblasts, and vascular endothelial and epithelial cells, in response to inflammatory stimuli, such as viral and bacterial infections. (
  • The inflammatory, chemotactic cytokine interleukin-8 (IL-8) is secreted by EC in response to IL-1 stimulation. (
  • In contrast to its effects on IL-8 expression, pyocyanin inhibits cytokine-dependent expression of the monocyte/macrophage/T-cell chemokine RANTES. (
  • IFN gamma did not affect IL-8 mRNA stability in LPS-treated PMN, indicating that the cytokine does not regulate LPS-induced IL-8 gene expression through post-transcriptional events. (
  • Baggiolini M, Clark-Lewis I (1992) Interleukin-8, a chemotactic and inflammatory cytokine. (
  • Levels of serum interleukin (IL)-1β, IL-5, IL-6, IL-8, IL-10, IL-17, interferon (IFN)-γ, tumor necrosis factor-α (TNF-α), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured using a bead-based multiplex cytokine kit in conjunction with flow-based protein detection and the Luminex LabMAP multiplex system in 18 cases and 21 controls. (
  • Monocyte-derived neutrophil chemotactic factor(MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. (
  • The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. (
  • Tau-Cl inhibition of IL-6 and IL-8 synthesis in FLS from RA patients results from the ability of this compound to diminish the activity of the major transcriptional regulators (NF-kappaB and AP-1), which subsequently reduces the transcription of these cytokine genes. (
  • MCP-1 and IL-8 mRNA were measured by real-time polymerase chain reaction. (
  • After stimulation with LPS, MCP-1 and IL-8 mRNA in ARPE-19 cells reached maximum levels at 3 h, and MCP-1 and IL-8 protein in the culture media reached maximum levels at 24 h. (
  • Berberine dose-dependently inhibited MCP-1 and IL-8 mRNA expression of the cells and protein levels in the media stimulated with LPS. (
  • In vitro treatment of human gastric cancer MKN-1 cells with exogenous IL-8 enhanced the expression of epidermal growth factor receptor, type IV collagenase (metalloproteinase-9), vascular endothelial growth factor, and IL-8 mRNA. (
  • In contrast, treatment with exogenous IL-8 decreased expression of E-cadherin mRNA. (
  • RNase protection assays indicate that increased IL-8 release is accompanied by increased levels of IL-8 mRNA. (
  • We recently showed that lipopolysaccharide (LPS) is a potent inducer of interleukin-8 (IL-8) expression in human polymorphonuclear leucocytes (PMN), at the level of both mRNA and protein, and that interferon-gamma (IFN gamma) inhibits IL-8 mRNA accumulation in stimulated PMN. (
  • As determined by Northern blot analysis, new protein synthesis was not required for the induction of IL-8 mRNA expression by LPS. (
  • Neither did the half-life of IL-8 mRNA in LPS-treated PMN differ from that observed in untreated cells. (
  • Furthermore, ELISA confirmed that NF‑κB activity in the escin‑treated PaCa cells was significantly inhibited and reverse transcription‑quantitative PCR showed that the mRNA expression levels of tumor necrosis factor‑α‑induced IL‑8 and VEGF were significantly suppressed following escin treatment in the PaCa cell lines. (
  • Specific induction of gastric epithelial IL-8 mRNA was examined by reverse transcription and polymerase chain reaction (RT-PCR) amplification. (
  • 0.01) in the expression of IL-8 mRNA relative to G3PDH mRNA was observed in KATO-3 cells after three hours of co-culture with CagA/cytotoxin positive strains. (
  • CONCLUSIONS--H pylori directly increases gastric epithelial IL-8 mRNA expression and IL-8 protein secretion in a strain specific manner. (
  • IL-8 mRNA was detected in unstimulated adult fibroblasts but not in fetal fibroblasts. (
  • Much less IL-8 mRNA was detected in stimulated fetal fibroblasts than in adult fibroblasts. (
  • IL-8 mRNA was detected 4 h after wounding in fetal and adult wounds. (
  • By 12 h no IL-8 mRNA was detected in fetal wounds, whereas adult wounds had IL-8 mRNA persisting to 72 h. (
  • IL-8 mRNA was 10-10 4 higher than tumor and 10 2 fold higher than benign tissue. (
  • [5] Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8 , leads to neutrophil chemotaxis and activation. (
  • Interleukin-8 and related CXC chemokines are involved in the function of neutrophils and T cells, and have been implicated in several lung diseases. (
  • Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family have a wide range of specific actions including the chemotaxis and activation of monocytes, the selective chemotaxis of memory T cells, the inhibition of hematopoietic stem cell proliferation, and the induction of neutrophil infiltration in vivo. (
  • A complementary DNA encoding the IL-8 receptor from human neutrophils has now been isolated. (
  • As a consequence of the diversity of effectors and downstream targets, IL-8 signaling promotes angiogenic responses in endothelial cells, increases proliferation and survival of endothelial and cancer cells, and potentiates the migration of cancer cells, endothelial cells, and infiltrating neutrophils at the tumor site. (
  • 2002. IL-8 and TNF-alpha from peripheral neutrophils and acute-phase proteins in periodontitis. (
  • Although neutrophils are the primary target, a variety of other cells also respond to the presence of IL-8. (
  • IL-8 plays pivotal roles in the recruitment and activation of polymorphonuclear leukocytes (PMNL), such as neutrophils [ 1 , 2 ]. (
  • Therefore, it is suggested that a positive amplification loop for IL-8 production, involving the sequential release of Lf and proteases from activated neutrophils by IL-8, exists in cattle. (
  • Increased release of IL-8, a potent neutrophil chemoattractant, in response to pyocyanin could contribute to the marked infiltration of neutrophils and subsequent neutrophil-mediated tissue damage that are observed in Pseudomonas -associated lung disease. (
  • IL-8, for example, is a chemoattractant that recruits neutrophils as well as basophils and T cells to damaged and infected peripheral tissues. (
  • 1 Recent investigations in animal models using either blocking antibodies against IL-8 or disruption of the gene encoding an IL-8 receptor have revealed the involvement of IL-8 and related chemokines in the recruitment of neutrophils and in neutrophil-associated tissue injury in acute inflammation. (
  • Seledtsov, Viktor Ivanovich 2018-03-01 00:00:00 Interleukin-8 (IL-8, CXCL8) belongs to major chemokines to stimulate migration of neutrophils and monocytes/macrophages (Mc/Mphs) into the inflammation sites. (
  • The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site. (
  • Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. (
  • In humans, the interleukin-8 protein is encoded by the CXCL8 gene. (
  • IL-8 je preimenovan u CXCL8 od strane Subkomiteta za hemokinsku nomenklaturu koje je deo Internacionalne unije imunoloških udruženja , [13] mada njegovo odobreni HUGO simbol gena ostaje IL8 . (
  • Interleukin-8/CXCL8 (IL-8) is a chemokine and angiogenic factor. (
  • Mechanism interleukin 8 is sometimes called CXCL8. (
  • Interleukin-8 (IL-8), alternatively known as CXCL8, is a proinflammatory CXC chemokine. (
  • Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°C between 2~7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). (
  • This protein is a receptor for interleukin 8 (IL8). (
  • Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atherosclerosis, the role of the classic C-X-C chemokine, interleukin-8 (KC/growth-related oncogene alpha in mice) and its receptor CXCR2 has not been studied in the pathogenesis of atherosclerosis. (
  • [1] [2] Kod ljudi, interleukin 8 je protein kodiran IL8 genom . (
  • IL-8RB binds to IL-8 with the same affinity as IL-8RA, but also binds to neutrophil-activating protein 2 (NAP-2) and other small receptor molecules of the CXC chemokine family with lower affinity than IL-8 binding, exhibiting a "shared" binding behavior. (
  • Transcription of the IL-8 gene encodes for a protein of 99 amino acids that is subsequently processed to yield a signaling competent protein of either 77 amino acids in nonimmune cells or 72 amino acids in monocytes and macrophages. (
  • Expression of IL-8 is primarily regulated by activator protein and/or nuclear factor-κB-mediated transcriptional activity, although additional hormone response elements and NF-IL-6 consensus sites have been characterized on the IL-8 gene promoter. (
  • In this study, we elucidated the effects of berberine, a major alkaloid component contained in medicinal herbs, such as Phellodendri Cortex and Coptidis Rhizoma , on expression of monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) in a human retinal pigment epithelial cell line (ARPE-19) caused by lipopolysaccharide (LPS) stimulation. (
  • MCP-1 and IL-8 protein concentrations in the media were measured using enzyme-linked immunosorbent assay. (
  • Sequence analysis of a 17-kb fragment revealed that adjacent to a block of conserved herpesvirus genes (major DNA-binding protein, glycoprotein B, and DNA polymerase), the genome of HHV-8 encodes structural homolog of IL-6. (
  • Researchers at UCLA have discovered that the levels of interleukin-8 (IL-8) protein in the saliva of healthy individuals and patients with oropharyngeal squamous cell carcinoma (OSCC) are 30 pM and 86 pM, respectively. (
  • PPD-B-stimulated interleukin 8 (IL-8) displayed the potential to differentiate M. bovis -infected cattle from NC, with an area under the curve (AUC) value of 0.9662, while PPD-B-stimulated C-reactive protein (CRP) displayed the potential to differentiate bTB PCR-P from bTB PCR-N , with an AUC value of 1.00. (
  • The present work examines whether human islet preparations produce VEGF as well as interleukin (IL)-8, another angiogenic protein, and assesses the role of contaminating duct cells in VEGF and IL-8-mediated angiogenesis. (
  • Circulating human IL-8 might be a useful, clinically relevant circulating tumor protein marker due to its positive correlation with multiple physiologic variables associated with lung cancer progression. (
  • These findings suggest that storage of IL-8 in Weibel-Palade bodies may serve as the EC "memory" of a preceding inflammatory insult, which then enables the cells to secrete IL-8 immediately without de novo protein synthesis. (
  • Induction of IL-8 secretion required live cells of 81-176 and was dependent on de novo protein synthesis. (
  • The antioxidant n -acetyl cysteine, general inhibitors of protein tyrosine kinases, and specific inhibitors of mitogen-activated protein kinases diminish pyocyanin-dependent increases in IL-8 release. (
  • Cells transfected with constructs comprising the proximal IL-8 promoter fused to luciferase or to green fluorescent protein cDNA exhibited enhanced reporter gene expression following toxin treatment. (
  • Here, we examined participation of protein kinase C (PKC) in SP-induced IL-8 production in human nontransformed NCM460 colonocytes stably transfected with the human NK-1R (NCM460-NK-1R cells). (
  • PKCδ silencing by RNA interference reduced PKCδ protein expression and SP-induced PKCδ phosphorylation that was associated with diminished IL-8 promoter and NF-κB luciferase activities in response to SP. (
  • Another cellular response to viral infection in either fibroblast or endothelial cells is the secretion of cytokines such as interferon-inducible protein 10 (IP-10), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein 1 (MCP-1), interleukin-1β (IL-1β), IL-8, and IL-6, which activate and attract cells of the immune system (reviewed in references 40 and 44 ). (
  • The type-1 receptor (IL-8R1, CXCR1) specifically binds IL-8 and granulocyte-chemoattractant protein (GCP)-2 (reviewed by Baggiolini and co-workers. (
  • Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding. (
  • These findings document new VKORC1v2-associated interactions and activities of vIL-6, revealing novel mechanisms of vIL-6 function within the ER compartment.IMPORTANCE HHV-8 vIL-6 pro-survival (latent) and pro-replication functions are mediated from the ER compartment through both gp130 receptor-mediated signal transduction and interaction of vIL-6 with the ER membrane protein VKORC1v2. (
  • The role of flagella in aEPEC 1711-4 adhesion, invasion, and IL-8 production was investigated by performing the same experiments with an isogenic aEPEC mutant unable to produce flagellin (FliC), the flagellum protein subunit. (
  • Gene and protein expression of ER alpha, ER beta, PR, IL-6 and IL-8 were measured by proximity ligation assay and qRT-PCR. (
  • Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (
  • In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst. (
  • H. Nakamura, K. Yoshimura, N. G. McElvaney, and R. G. Crystal, "Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line," Journal of Clinical Investigation , vol. 89, no. 5, pp. 1478-1484, 1992. (
  • These results suggest that after an intramammary infusion of IL-8 has elicited inflammatory responses, it induces the prolonged secretion of elastase, inflammatory LDP, and IL-8, and that long-lasting IL-8-induced inflammatory reactions are involved in the pathogenesis of S. aureus dry-period mastitis. (
  • We have recently demonstrated that infusing recombinant bovine (rb) IL-8 into the teat cisterns of dairy cows during the drying-off period induces inflammatory reactions similar to mastitic symptoms including the infiltration of PMNL into mammary secretions, a decreased casein concentration, and the transient elevation of rectal temperature [ 25 ]. (
  • However, the signal transduction pathways by which SP-NK-1R interaction induces NF-κB activation and interleukin-8 (IL-8) production are not clear. (
  • These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (
  • Interleukin-8 and its receptor CXCR2 in atherosclerosis. (
  • In contrast, SCLC cell lines produced very low or undetectable levels of IL-8, but expressed CXCR1 and CXCR2. (
  • C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) pipeline Target constitutes close to 16 molecules. (
  • The latest report C-X-C Chemokine Receptor Type 2 - Pipeline Review, H2 2018, outlays comprehensive information on the C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (
  • Furthermore, this report also reviews key players involved in C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics development with respective active and dormant or discontinued projects. (
  • Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer. (
  • Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. (
  • While neutrophil granulocytes are the primary target cells of IL-8, there are a relatively wide range of cells (endothelial cells, macrophages, mast cells, and keratinocytes) that respond to this chemokine. (
  • Activated endothelial cells induce apoptosis in leukemic cells by endothelial interleukin-8," Blood , vol. 92, no. 8, pp. 2672-2680, 1998. (
  • As well as the primary neutrophil granulocytes, other cells that respond to IL-8 include: macrophages, mast cells, keratinocytes, and endothelial cells. (
  • Human recombinant IL-8 was potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells. (
  • The expression and secretion of interleukin (IL)-8, the prototype member of the C-X-C subfamily of chemokines, can be induced by diverse inflammatory stimuli in many cells, including endothelial cells (EC). (
  • Recently, sera from children with active Henoch-Schönlein purpura (HSP) have been found to enhance interleukin (IL)-8 production by human umbilical venous endothelial cells (HUVEC). (
  • The supernatant IL-8 levels of endothelial cells stimulated by IgA derived from acute stage of HSP were statistically higher than controls (P (
  • Together with these findings, it is concluded that IgA AECA derived from acute stage of HSP may bind to endothelial and enhance endothelial cells to produce IL-8 via MEK/REK signalling pathway. (
  • Ex vivo clotting of human blood stimulates interleukin 8 (IL-8) and IL-6 production by monocytes and endothelial cells ( 13 , 14 ). (
  • It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies.When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. (
  • 12 ] reported that MCP-1 and IL-8 are produced at much higher levels than other chemokines tested in RPE cells. (
  • Interleukine 8 is also called a neutrophil attractant and belongs to the group of chemokines. (
  • Interleukin-8 (IL-8) is a potent member of the supergene family of CXC chemokines with ELR motif (ELR+). (
  • The anti-IL-8 monoclonal antibody also significantly reduced air space neutrophil counts and IL-8 concentrations. (
  • An equation y = (A-D)/(1 + (x/C)^B) + D was generated from the standard curve and used to calculate IL-8 concentrations shown in the Figure 1 and Table 1. (
  • In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration. (
  • In this study, we present the development of the first immunoassay for the quantification of picomolar IL-8 concentrations in human saliva using Biacore surface plasmon resonance ( SPR ) in a microfluidic channel. (
  • Serum IL-2 was assayed by radioimmunometric assay, and serum IL-6 and IL-8 concentrations were measured by quantitative enzyme-linked immunosorbent assay in patients and 30 sex- and age-matched normal subjects. (
  • Neither risperidone nor haloperidol showed significant influence on the higher serum IL-6 or IL-8 concentrations in schizophrenia. (
  • Correlations between serum IL-2 or IL-8 concentrations at baseline and the therapeutic outcome were observed, demonstrating that patients presenting with low concentrations of serum IL-2 or IL-8 at baseline showed greater improvement and patients presenting with higher serum IL-2 or IL-8 concentrations at baseline showed less improvement after treatment. (
  • Those with CF who had raised pepsin concentrations had higher levels of IL-8 in the BAL fluid than those with a concentration comparable to controls (3.7 (2.7) ng/ml vs 1.4 (0.9) ng/ml, p=0.004). (
  • Increased pepsin levels were associated with higher IL-8 concentrations in BAL fluid. (
  • Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-κB activity and interleukin-8 expression in both cell lines at even lower concentrations. (
  • Baseline IL-8 concentrations were higher in women than in men (P = 0.03). (
  • Here we report that the activation of coagulation in healthy human subjects by the administration of recombinant factor VIIa also elicits a small but significant increase in the concentrations of interleukin 6 (IL-6) and IL-8 in plasma. (
  • Furthermore, IL-8 then proceeds to induce phagocytosis when the cells it has influenced arrive at the infection site. (
  • Inflammatory LDP containing the GQRDLLFKDSAL sequence, such as the 22 and 23 kDa peptides, induce IL-8 gene expression in bovine mammary epithelial cells [ 22 ], which are major sources of IL-8 production in the mastitic mammary gland [ 23 , 24 ]. (
  • In this study, we show that platelets activated with either adenosine- 5'-diphosphate or epinephrine induce IL-8 secretion by EC. (
  • These observations show that activated platelets induce IL-8 secretion via membrane-associated IL-1 activity, and provide a novel relationship between coagulation and inflammation that could be relevant to several diseases. (
  • Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. (
  • HNPs induce IL-8 in lung epithelial cells and monocytes through the P2Y6 signaling pathway. (
  • Helicobacter pylori , the primary cause of active chronic gastritis in humans, is known to induce interleukin-8 (IL-8) release from a variety of epithelial cells in vitro ( 19 , 35 ). (
  • This ability of H. pylori to induce IL-8, a potent chemoattractant and cellular activator, is considered a major virulence determinant. (
  • One study of IL-8 induction by H. pylori in a gastric epithelial cell line also showed that C. jejuni 81-176 could induce some IL-8 secretion ( 35 ). (
  • can induce secretion of IL-8 by the intestinal epithelial cell line INT407. (
  • and (2) if CagA/cytotoxin positive and negative strains of H pylori differ in their ability to induce epithelial IL-8. (
  • The PKCδ inhibitor rottlerin at a low concentration (1 μM), but not pseudosubstrate PKCθ and PKCϵ inhibitors (10 μM), significantly reduced IL-8 secretion. (
  • FAK and ERK1/2 inhibitor also decreased IPDI-BEAS-2B-CM-, IPDI-HBEC-CM- and recombinant human IL-8-mediated BSMC proliferation and migration, whereas blocking Rnd3 using small interfering RNA failed to affect BSMC proliferation, suggesting that Rnd3 was only involved in the regulation of BSMC migration. (
  • A single intramammary infusion of recombinant bovine interleukin-8 (IL-8) at 50 μ g/quarter/head, but not 10 μ g/quarter/head, induced clinical mastitis in three of four cows during the dry-off period, resulting in an elevated rectal temperature, redness and swelling of the mammary gland, extensive polymorphonuclear leukocyte (PMNL) infiltration, and milk clot formation from 1 to 28 days post infusion (PI). (
  • We also examined the effects of IL-8 on the expression of disease-progression genes by treating gastric carcinoma cell lines with recombinant IL-8. (
  • Interleukin-8 Porcine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8291 Dalton. (
  • IL 8 Rhesus Macaque Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.The IL 8 Rhesus Macaque is purified by proprietary chromatographic techniques. (
  • Recombinant IL-8 increased endothelial permeability by activating eNOS, S-nitrosylation of VE-cadherin and p120, internalization of VE-cadherin and disassembly of adherens junctions. (
  • IL-8 is also known to be a potent promoter of angiogenesis. (
  • Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. (
  • We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. (
  • Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies. (
  • IL-8 is a known promoter of angiogenesis. (
  • Accordingly, IL-8 expression correlates with the angiogenesis, tumorigenicity, and metastasis of tumors in numerous xenograft and orthotopic in vivo models. (
  • These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair. (
  • Our previous study reported that NF‑κB enhanced the secretion of interleukin (IL)‑8 and vascular endothelial growth factor (VEGF), thereby inducing angiogenesis in PaCa cell lines. (
  • These results indicated that escin inhibited angiogenesis by reducing the secretion of IL‑8 and VEGF by blocking NF‑κB activity in PaCa. (
  • Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. (
  • CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α. (
  • Here, we investigated the expression and function of IL-8 in lung cancer cells. (
  • Stimulation of cell proliferation by IL-8 was also demonstrated by analysis of proliferating cell nuclear antigen expression and cell cycle in H69 cells. (
  • The induction of IL-8 signaling activates multiple upstream signaling pathways that ( a ) impinge on gene expression via regulation of numerous transcription factor activities, ( b ) modulate the cellular proteome at the level of translation, and/or ( c ) effect the organization of the cell cytoskeleton through posttranslational regulation of regulatory proteins. (
  • 1999). Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation. (
  • These findings indicate that berberine inhibited the expression of MCP-1 and IL-8 induced by LPS. (
  • In the present study, we investigated the effects of berberine on MCP-1 and IL-8 expression in ARPE-19 cells stimulated with LPS. (
  • Moreover, the IL-8 gene expression level and polymorphisms in the IL-8 receptor- α (CXCR1) gene are related to the incidence and severity of diseases such as mastitis [ 17 , 18 ]. (
  • IL-8 expression was assessed in PC tissue microarrays. (
  • The relationships among the baseline variables, CC, and IL-8 expression with disease progression were examined using univariate and multivariate analyses. (
  • IL-8 expression in tissue samples was also positively associated with weight loss. (
  • RESEARCH DESIGN AND METHODS- Human islet and pancreatic duct cell preparations are compared for their respective expression and production of VEGF and IL-8 during culture as well as following transplantation in nonobese diabetic (NOD)/scid mice. (
  • The increased expression of interleukin-8 (IL-8) has also been demonstrated in the colonic mucosa of patients with active ulcerative colitis. (
  • We observed a significant increase in IL-8 expression in the human colon carcinoma cell line, Caco-2, following treatment with HNP-1. (
  • The non-selective P2 receptor antagonists, suramin and pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid) tetrasodium salt hydrate (PPADS), significantly blocked the HNP-1-induced expression of IL-8 in the Caco-2 cells. (
  • The expression of interleukin 8 (IL-8) by human gastric carcinomas directly correlates with tumor vascularity and disease progression. (
  • Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. (
  • To further define the molecular basis of the regulation of IL-8 gene expression in PMN, we investigated the effects of LPS and IFN gamma at both the transcriptional and post-transcriptional levels. (
  • These results provide the first evidence that human granulocytes can actively transcribe the IL-8 gene, and that transcriptional inhibition is the mechanism by which IFN gamma inhibits IL-8 gene expression in PMN. (
  • We showed that upon LPS activation of Mc/Mphs, IL-8 reduced markedly both the percentages and median fluorescence intensity (MFI) of CD16 (FcγRIII)-positive cells among CD14high cells, as well as in cells that reduced the expression of СD14 during their culturing. (
  • IL-8 was also found to be capable of reducing the expression of СD124 (IL-4 receptor subunit alpha, IL-4RA), with concomitant enhancement of the expression of both CD119 (interferon-gamma receptor 1) and CD197 (CCR7) in Mph cells. (
  • Infection of cells with an adenoviral construct of the mouse LPP-1 (R217K) mutant partially attenuated LPA-induced IL-8 secretion without altering LPA-induced changes in intracellular Ca 2+ concentration, phosphorylation of IκB, NF-κB activation or IL-8 gene expression. (
  • These observations suggest that GRO-α and -β may exhibit expression profiles similar to IL-8. (
  • Coordinated expression of these and other factors with IL-8 in certain tumor tissues suggests that they may be functionally associated with IL-8 in these tumors. (
  • Interleukin-6 (IL-6) and interleukin-8 (IL-8) may influence tumor response to therapy but expression in BCSCs is also unknown. (
  • We speculated that inhibition of COX-2 activity might reduce expression of the pro-angiogenic factors vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) in lung cancer cells. (
  • We have shown previously that interleukin-8 (IL-8) and IL-8 receptor expression is elevated in tumor cells of human prostate biopsy tissue and correlates with increased cyclin D1 expression. (
  • Using PC3 and DU145 cell lines, we sought to determine whether IL-8 signaling regulated cyclin D1 expression in androgen-independent prostate cancer (AIPC) cells and to characterize the signaling pathways underpinning this response and that of IL-8-promoted proliferation. (
  • Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage. (
  • During placental preeclampsia experiencing oxidative stress, oxidative stress can increase the expression and activation of nuclear factor-kappa B which regulates the levels of TNF α ( Tumor necrosis factor-α), interleukin-6, interleukin-8, COX-2 (Cyclooxygenase-2) genes. (
  • Serum interleukin-8 (IL-8), p53, vascular endothelial growth factor, and matrix metalloproteinase-9 were quantitated for correlation with physiologic measurements. (
  • We find that pyocyanin increases release of interleukin-8 (IL-8) by both normal and CF airway epithelial cell lines and by primary airway epithelial cells. (
  • CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. (
  • METHODS--Gastric epithelial cell lines were co-cultured with H pylori NCTC 11637 and 10 clinical isolates (four cytotoxic, six non-cytotoxic) and secreted IL-8 was measured by enzyme linked immunosorbent assay (ELISA). (
  • RESULTS--H pylori (NCTC 11637) induced IL-8 secretion from three gastric epithelial cell lines (KATO-3, ST42, AGS) but not from MKN 45 (gastric) or intestinal (SW480, HT29) cell lines. (
  • Angiogenic activity present in the conditioned media of inflamed human rheumatoid synovial tissue macrophages or lipopolysaccharide-stimulated blood monocytes was equally blocked by antibodies to either IL-8 or tumor necrosis factor-alpha. (
  • An IL-8 antisense oligonucleotide specifically blocked the production of monocyte-induced angiogenic activity. (
  • RESULTS- Cultured pancreatic duct cells expressed 3- and 10-fold more VEGF and IL-8, respectively, than cultured human islet endocrine cells and released both proteins at angiogenic levels. (
  • The angiogenic effect of purified duct cells was higher than that of purified endocrine islet cells and was completely blocked by a combination of IL-8 and VEGF antibodies. (
  • Moreover, such angiogenic action might be less pronounced in human islet cell preparations, since they contain much lower percentages of β-cells than isolated rodent islets ( 8 ). (
  • Interleukin 8 has also an angiogenic activity and is involved in the formation of metastases [10, 37]. (
  • Viral interleukin-6 (vIL-6) encoded by human herpesvirus 8 (HHV-8) is believed to contribute via mitogenic, survival, and angiogenic activities to HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease through autocrine or paracrine mechanisms during latency or productive replication. (
  • Our study suggests that inhibition of IL-8 or IL-8-mediated FAK/ERK/Rnd3 signalling is an attractive therapeutic target for IPDI-mediated asthma. (
  • Inhibition of interleukin 8/C‑X-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells. (
  • The prolonged stimulation of primary human EC with inflammatory mediators resulted in the accumulation of IL-8 in Weibel-Palade bodies, where it colocalized with von Willebrand factor. (
  • In this study, we show that, after prolonged inflammatory stimulation, IL-8 accumulates in Weibel-Palade bodies in primary human EC, where it remains stored after the stimulation is discontinued and can be released instantaneously upon restimulation with EC secretagogues. (
  • These results indicate that extracellular adenosine can regulate ERK, c-Jun N-terminal kinase, and p38 MAPK signaling cascades and that activation of ERK and p38 MAPK pathways are essential steps in adenosine A 2B receptor-dependent stimulation of IL-8 production in HMC-1. (
  • In the Caco-2 BBE model of polarized villus-like epithelium, apical stimulation with TLR2 and TLR5 ligands resulted in the apical secretion of IL-8. (
  • Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. (
  • Kaposi's sarcoma is a multifocal lesion that is reported to be greatly influenced by cytokines such as interleukin-6 (IL-6) and oncostatin M. DNA sequences of a novel human gammaherpesvirus, termed human herpesvirus 8 (HHV-8) or Kaposi sarcoma-associated herpesvirus, have been identified in all epidemiological forms of Kaposi's sarcoma with high frequency. (
  • Of these mentioned cytokines, only serum IL-8 level was elevated in the locally advanced group ( n = 55) compared with the normal ( n = 17) and resected groups ( n = 55). (
  • The aim of this study was to compare the effect of typical and atypical antipsychotic drugs on serum interleukin-2 (IL-2), interleukin-6 (IL-6), and interleukin-8 (IL-8) and to investigate the relationship between the changes in cytokines and the therapeutic outcome in schizophrenia. (
  • Proinflammatory cytokines i.e. interleukins (IL-6) and (IL-8) seem to play an important role in inflammatory processes in male genital tract. (
  • Similar to other cytokines, IL-8 is present in the human seminal plasma [7, 19, 37]. (
  • We show here that cells infected with 3A-2 mutant virus secrete greater amounts of cytokines interleukin-6 (IL-6), IL-8, and beta interferon than cells infected with wild-type poliovirus. (
  • Several types of cytokines have been shown to increase in preeclampsia and may be used as a marker of preeclampsia [ 8 , 13 ]. (
  • It is suggested that the two alpha-helices form the binding site for the cellular receptor and that the specificity of IL-8, as well as that of a number of related proteins involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response, is achieved by the distinct distribution of charged and polar residues at the surface of the helices. (
  • IL-8, also known as neutrophil chemotactic factor, has two primary functions. (
  • Interleukin-8 (IL-8), also known as neutrophil chemotactic factor, belongs to the CXC chemokine family and mainly serves as an immune mediator of neutrophil-dependent acute inflammation (2). (
  • Interleukin-8: a potent neutrophil chemotactic factor. (
  • Methods: The levels of plasma IL-6 and IL-8 were measured by the sandwich enzyme linked immunosorbent assay (ELISA) method in 15 hemodialysis (HD) patients with end-stage renal failure (ESRF) before and post HD. (
  • LS-F13700 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Pig IL8 / Interleukin 8. (
  • Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity. (
  • IL-8 is produced in various cells and tissues such as phagocytes and mesenchymal cells exposed to inflammatory stimulus, and primarily targets the recruitment and activation of neutrophil granulocytes and other intra-and extracellular changes in response to infection, inflammation, trauma, environmental stress, and steroid hormones, etc. (
  • The role of interleukin-8 in inflammation and mechanisms of regulation. (
  • Interleukin-8 (IL-8) is an important mediator of the host response to injury and inflammation that the clinical severity of oral lichen planus (OLP) is associated with elevated serum IL-8 levels. (
  • To determine the role of the murine interleukin-8 receptor homologue (mIL-8Rh, neutrophil chemokine CXC receptor 2) in leukocyte migration using intravital microscopy in a standardized model of eye inflammation, endotoxin-induced uveitis (EIU). (
  • Although IL-8 has previously been implicated in cell adhesion, video imaging in vivo demonstrated that deletion of the IL-8 receptor homologue had minimal effect on rolling or arrest in this model of inflammation. (
  • Interleukin-8 (IL-8) stimulates inflammation in postnatal wound healing but little is known about its role in fetal wounds. (
  • Five databases including PubMed/Medline, Web of Science, Science Direct, Cochrane Library and Scopus were searched for the evaluation of serum and salivary IL-8 levels of the OLP patients compared with the healthy controls in the English abstract. (
  • IL-8 diproduksi oleh berbagai macam sel, termasuk monosit , neutrofil , sel T , fibroblas , sel endotelial dan sel epitelial , setelah terpapar antigen atau stimulan radang (ischemia dan trauma). (
  • Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. (
  • Primarna funkcija IL-8 citokina je da regrutuje neutrofile da fagocitoziraju antigen koji je pobudio antigenski obrazac toll-sličnog receptora. (
  • We have now shown that blockade of the IL-8/IL-8R axis is effective at reverting the phenotype of the tumor cells towards a more epithelial one, decreasing stemness features, and significantly enhancing tumor sensitivity to chemotherapy, small-molecule targeted therapies, and immune-mediated lysis with NK and antigen-specific T cells in vitro. (
  • A sandwich assay using two monoclonal antibodies, which recognize different epitopes on the antigen (IL-8), was used. (
  • Interleukin 8 receptor, alpha is a chemokine receptor . (
  • C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin 8 Receptor A or IL8 Receptor Type 1 or CD181 or CXCR1) pipeline Target constitutes close to 8 molecules. (
  • It also reviews key players involved in C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin 8 Receptor A or IL8 Receptor Type 1 or CD181 or CXCR1) targeted therapeutics development with respective active and dormant or discontinued projects. (
  • IL-8 and its homologues are known to be potent signals for leukocyte migration. (
  • Our results demonstrate, for the first time, the involvement of a member of the PKD family in the production of IL-8, a potent proinflammatory chemokine, by epithelial cells. (
  • Exogenous IL-8 significantly stimulated cell proliferation in four SCLC cell lines tested in a dose-dependent fashion. (
  • In conclusion, elevated serum IL-8 level significantly correlates with CC and sarcopenia and can be used as a prognostic indicator in PC. (
  • In agreement with this finding, HNP-1 also significantly increased IL-8 production in the P2Y6-negative human colon cancer cell line, HT-29, and this increase was blocked by treatment with suramin and PPADS. (
  • Results: The plasma of IL-6 and IL-8 levels in the CA and HE groups were significantly higher than that of patients in the Psu group, NHD patients and normal subjects ( p (
  • IL‐8 also significantly improved predictive models of fatigue based on severity. (
  • All the envenomed victims showed significantly higher mean values of CPK, CPK-MB, LDH, and IL-8 on admission in comparison to control group. (
  • The mean values of CPK, CPK-MB, LDH, and IL-8 were significantly higher in severe cases while only IL-8 and CPK-MB were significantly higher in moderate cases in comparison with mild cases. (
  • The mean values of IL-8, cTnI, CPK, CPK-MB and LDH were significantly higher in severe cases both on admission and on follow-up comparing with moderate cases. (
  • PD98059, an inhibitor of ERK phosphorylation, significantly reduced IgA AECA-stimulated endothelial IL-8. (
  • TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. (
  • VEGF was significantly decreased in A549 (by 24%) and in MOR/P (by 53%), but not in H460 whereas IL-8 was not affected in any cell line. (
  • Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high affinity. (
  • Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium. (
  • The binding affinities, obtained by isothermal fluorescence titration, of size-defined heparin and HS oligosaccharides to the chemokine were found to depend on the oligomerization state of IL-8: high affinity was detected for monomeric and low affinity was detected for dimeric IL-8, referring to a self-regulatory mechanism for its chemoattractant effect. (
  • This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. (
  • IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. (
  • We investigated the role of interleukin 8 (IL-8) in the pathogenesis of proliferative vitreoretinopathy (PVR). (
  • These results suggest that IL-8 may play a role in the pathogenesis of PVR. (
  • Thus, MCP-1 and IL-8 may be involved in part in the pathogenesis of intraocular disorders. (
  • This conservation of essential features and the remarkable overlap between diseases associated with HHV-8 and diseases associated with IL-6 disregulation clearly suggest that vIL-6 is involved in HHV-8 pathogenesis. (
  • Also, IL-8 may be involved in the pathogenesis of myocardial injury of scorpion envenomation. (
  • In the present study, we investigated the effects of HNP-1 on the production of IL-8 by human intestinal epithelial cells and the underlying signaling mechanisms. (
  • The ability of some typical enteropathogenic Escherichia coli (EPEC) strains to adhere to, invade, and increase interleukin-8 (IL-8) production in intestinal epithelial cells in vitro has been demonstrated. (
  • Our findings demonstrate that flagella of aEPEC 1711-4 are required for efficient adhesion, invasion, and early but not late IL-8 production in intestinal epithelial cells in vitro. (
  • Here we investigated whether polarized monolayers of intestinal epithelial cells might regulate inflammatory responses by secreting IL-8 in a vectorial fashion (i.e. apical versus basolateral) depending on the location of the TLR stimulus. (
  • Intestinal epithelial cells (IECs) play a key role in the inflammatory response to colonizing or invading microorganisms via the secretion of interleukin-8 (IL-8). (
  • This study addresses the role of LPPs in regulating LPA-mediated cell signalling and IL-8 (interleukin-8) secretion in HBEpCs (human bronchial epithelial cells). (
  • It has been noted that the macrophages are among the first cells to release IL-8 to its work of recruiting other cells to mobilize to the site of infection. (
  • Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. (
  • Dari beberapa kemokina yang memicu kemotaksis neutrofil , IL-8 merupakan chemoattractant yang terkuat. (
  • Two weeks after laser treatment, antibodies against the following factors were injected intravitreally in groups 1 to 7: PBS as a control, VEGF, IL-8, VEGF+IL-8, PDGF-beta, PDGF-beta+IL-8, PDGF-beta+VEGF (n=8 for each group). (
  • CNV parameters were smaller when anti-VEGF or anti-IL-8 were injected alone, combined or together with anti-PDGF-beta, reaching statistical significance for the values of proliferation area and laser spot size in choroidal flat mounts after injection of anti-VEGF + anti-IL-8. (
  • The results clearly indicate that sizes of mature laser spots in the experimental model of laser-induced CNV are reduced after intravitreal injection of an anti-IL-8 antibody alone or in combination with anti-VEGF or anti-PDGF-beta antibodies, thus possibly opening a new way to deal with treatment-resistive neovascularisations. (
  • Human duct cell implants under the kidney capsule of NOD/scid mice expressed higher levels of IL-8 and VEGF than human islet cell implants and induced circulating IL-8 and VEGF levels during the first day posttransplantation. (
  • CONCLUSIONS- Human duct cell-released IL-8 and VEGF may help revascularization of currently used human islet cell grafts. (
  • ELISA also showed that escin decreased the secretion of IL‑8 and VEGF from the PaCa cells. (
  • The levels of IL-8, VEGF and prostaglandin E 2 (PGE 2 ) were measured by ELISA. (
  • We conclude that NSCLC cells produce much higher levels of IL-8 than SCLC cells whereas both NSCLC and SCLC cells produce similar levels of VEGF. (
  • We speculate that combined targeting of COX-2 and IL-8 may be useful in the treatment of patients with NSCLC and targeting VEGF may be useful in the treatment of patients with SCLC. (
  • These include platelet-activating factor, interleukin (IL)-6, granulocyte-macrophage colony-stimulating factor, and melanoma-growth stimulating activity. (
  • The MDNCF/IL-8 gene is placed on the human gene map at position 4q12-q21. (
  • IL-8 levels in the vitreous did not correlate with either the grade of PVR or the duration of symptoms. (
  • Studies have shown that if a pregnant woman has high levels of IL-8 during pregnancy, there is increased risk of schizophrenia in her children. (
  • In addition to the above, high levels of IL-8 have also been shown to impact positive responses in schizophrenic patients. (
  • Our findings suggested that IL-35 produced from regulatory T cells might inhibit progression of periodontitis by decreasing IL-17A-induced levels of IL-6 and IL-8. (
  • Mouse serum was used as negative control, there were no detectable levels of IL-8. (
  • In the mammary secretions of the mastitic glands, high levels of IL-8 were sustained from 8 hours to 28 days PI, peaking at 1-3 days PI. (
  • In addition to the experimentally induced mastitis, the mammary secretions from the glands of cattle with spontaneous Staphylococcus aureus dry-period mastitis displayed milk clot formations and significant increases in their levels of PMNL counts, elastase, LDP, and IL-8, compared with those of the mammary secretions from the uninfected glands. (
  • Diagnostic sensitivity for oral cancer can be achieved by pre-concentrating the saliva samples 10 fold prior to SPR analysis, making the target levels of IL-8 300 pM for healthy individuals and 860 pM for oral cancer patients. (
  • To determine whether interleukin-8 (IL-8) serum levels are correlated with pelvic pain in patients with ovarian endometriomas. (
  • group B, severe dysmenorrhea and/or chronic pelvic pain and/or dyspareunia) who underwent surgery for cystic ovarian endometriosis to asses whether a correlation exists between IL-8 serum levels and pelvic pain. (
  • The mean (+/-SD) IL-8 serum levels in group A were 6.41 +/- 12.17 pg/mL and in group B were 6.52 +/- 8.73 pg/mL. (
  • Pain symptoms in ovarian endometriosis is not correlated with IL-8 serum levels. (
  • also known as gelatinase-B), p53, and interleukin-8 (IL-8) are expressed at various levels by NSCLC ( 10 - 12 ). (
  • Incubation of INT407 cells with various clinical isolates of Campylobacter jejuni resulted in secretion of interleukin-8 (IL-8) at levels ranging from 96 to 554 pg/ml at 24 h. (
  • The strains which produced the highest levels of IL-8 secretion were 81-176 and BT44. (
  • Site-specific mutants of 81-176, which were previously shown to be defective in adherence and invasion, resulted in reduced levels of secretion of IL-8, and cheY mutants of strains 81-176 and 749, which are hyperadherent and hyperinvasive, resulted in higher levels of IL-8 secretion. (
  • Another mutant of 81-176, which adheres at about 43% of the wild-type levels but is noninvasive, also showed marked reduction in IL-8 levels, suggesting that invasion is necessary for high levels of IL-8 secretion. (
  • Moreover, the strains which produce the highest levels of IL-8 are the more invasive strains in vitro, and adherence and/or invasiveness of C. jejuni appears to be associated with induction of IL-8 secretion. (
  • Interleukin-8 (IL-8), pepsin, neutrophil numbers and neutrophil elastase activity levels were measured in all samples. (
  • There was also no difference in the levels of IL-6 and IL-8 in patients dialyzed with the three different dialyzers between pre- and post-dialysis. (
  • However, a significant positive linear correlation existed between the plasma IL-6 and IL-8 levels ( p (
  • Conclusions: Our results suggest that the levels of plasma IL-6 and IL-8 were related to the type of dialyzers and could be used as indices evaluating the biocompatibility of dialyzers. (
  • 1) To investigate the significance of assessment of serum levels of cardiac troponin I (cTnI) and interleukin-8 (IL-8) beside other biomarkers of myocardial injury in scorpion envenomed children. (
  • The serum levels of cTnI and IL-8 beside the enzymatic activities of creatine phosphokinase (CPK), CPK-MB isoenzyme (CPK-MB) and lactate dehydrogenase (LDH) were determined once for mild cases and controls on admission and twice for severe and moderate cases on admission and after 24 hrs. (
  • Mozaffari H, Sharifi R, Mirbahari S, Montazerian S, Sadeghi M, Rostami S. A systematic review and meta-analysis study of salivary and serum interleukin-8 levels in oral lichen planus. (
  • To evaluate serum and salivary IL-8 levels of the OLP patients compared with the healthy controls and measurement of IL-8 level in which sample is more valuable. (
  • The higher levels of IL-8 in saliva compared with serum levels suggest that measurement of this marker in saliva may be more useful than serum measurements for determining therapeutic and diagnostic aims. (
  • A weak association between IL-8 serum levels and an increased risk for mortality was observed. (
  • Assays for prothrombin activation fragment F1+2, factor X activation peptide, and the levels of factor VIIa, tumor necrosis factor (TNF), IL-6, IL-8, soluble TNF receptor type 1 (sTNF-R1), IL-1 receptor antagonist (IL-1ra) and sE-selectin in plasma were performed according to the instructions of the manufacturer and were described previously ( 8 , 10 , 18 ). (
  • IL-6 and IL-8 proteins showed overlapping levels of expressions among various tissues and cell populations. (
  • IL-6 levels at 2 and 12 hours after cardiopulmonary bypass (CPB) and IL-8 levels at 2, 12 and 24 hours were associated with the development of AKI using the Wilcoxon rank-sum test and after adjustment for age, gender, race, and prior cardiac surgery in multivariate logistic regression analysis. (
  • IL-8 levels at 2 hours had excellent predictive value for prolonged mechanical ventilation in all patients. (
  • Measurement of TNF-α levels and Interleukin-8 levels using ELISA (Enzyme-linked immune sorbent assay). (
  • TNF-α levels and interleukin-8 levels showed a decreased level after being given treatment at a dose of 1500 mg/kg body weight. (
  • Black cumin extract has a positive effect to reduce serum TNF-α and serum interleukin-8 levels to be used as a therapy for preeclampsia disorders. (
  • CONCLUSION: In vitro, IL-8 increases contractile response of the ileum to ACh in a dose-dependent manner. (
  • We studied the direct effects of IL-8 on the functionality of human Mc/Mphs in vitro. (
  • IL-8 is produced and released from human adipose tissue and from isolated adipocytes in vitro, which may indicate that IL-8 from adipose tissue could be involved in some of the obesity-related complications. (
  • Our studies clearly demonstrate that gastric carcinoma cells express both IL-8RA and IL-8RB and that the IL-8 receptor system may play a role in the processes of invasion and metastasis. (
  • IL-8 is also found to be constitutively expressed in several tumor tissues including bronchogenic carcinoma, non-small cell lung cancer, colorectal carcinoma, breast cancer, melanoma, prostate cancer, gastric carcinoma, and ovarian cancer. (
  • IL-8RA is highly specific for interleukin-8 and only responds when this particular ligand is bound to its receptor site, exhibiting "specific" binding behavior. (
  • J. J. Oppenheim, K. Matsushima, C. G. Larsen, and A. O. Anderson, "Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor," Immunology , vol. 68, no. 1, pp. 31-36, 1989. (
  • The aim of this study was to clarify the effect of IL-35 on IL-6 and IL-8 production in human periodontal ligament cells (HPDLCs) stimulated with IL-17A. (
  • IL-35 inhibited IL-6 and IL-8 production in IL-17A-stimulated HPDLCs. (
  • Exposure of BEAS-2B cells and HBECs to IPDI increased interleukin (IL)-8 production. (
  • However, the HNP-1-induced production of IL-8 was suppressed by the ERK1/2 inhibitor, U0126, but not by the p38 MAPK inhibitor, SB203580. (
  • Depletion of PKC by phorbol-12-myristate-13-acetate (10 μM) blocked SP-induced IκBα and p65 phosphorylation and IL-8 production. (
  • In addition, IL-8 up-regulated production of IL-6 and IL-1β [but not tumor necrosis factor-α (TNF-α) and IL-10] by activated Mc/Mphs. (
  • To further determine the possible factor with the ability to enhance endothelial IL-8 production in sera from acute stage of HSP, 10 children with HSP at the acute stage and 10 healthy controls were enrolled. (
  • The ability of these factors to enhance endothelial IL-8 production was evaluated. (
  • The active sera could enhance endothelial IL-8 production (P= 0·004, compared with control sera), and the ability of these sera was mostly abolished when pretreated with fixed anti-human IgA antibody. (
  • Diminished Interleukin-8 (IL-8) Production in the Fetal Wound Healing Response Liechty, Kenneth W. (
  • In this study, we evaluated a selected aEPEC strain (1711-4) of serotype O51:H40, the most prevalent aEPEC serotype in Brazil, in regard to its ability to adhere to and invade Caco-2 and T84 cells and to elicit IL-8 production in Caco-2 cells. (
  • In addition, the aEPEC 1711-4 fliC mutant had a reduced ability to stimulate IL-8 production by Caco-2 cells in early (3-h) but not in late (24-h) infections. (
  • LPA induced a striking increase in IL-8 production and stimulated NF-κB activation, as measured by NF-κB-DNA binding, NF-κB-driven luciferase reporter activity, and IκBα phosphorylation. (
  • PKD 2 gene silencing utilizing small interfering RNAs targeting distinct PKD 2 sequences dramatically reduced LPA-stimulated NF-κB promoter activity and IL-8 production. (
  • In contrast, IL-8 production is COX-2 independent in both NSCLC and SCLC cells. (
  • We investigated whether the location (i.e. apical or basolateral) of TLR agonists influenced the production and direction of IL-8 secretion. (
  • Recently, IL-8 was identified as an autocrine growth factor in several human cancers. (
  • In conclusion, IL-8 can act as an autocrine and/or paracrine growth factor for lung cancer cells, and the mitogenic function of IL-8 in lung cancer is mediated mainly by CXCR1 receptor. (
  • IL-8, a member of the CXC chemokine family, is produced by NSCLC cells as an autocrine growth factor ( 25 - 27 ). (
  • Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (
  • To examine the IL-8 response of fibroblasts to PDGF, cultures of human fetal (17-18 weeks) and adult dermal fibroblasts were incubated 8 h with PDGF (0, 0.1, 1, or 10 ng/mL) and supernatants and cells were collected for IL-8 ELISA and IL-8 RT-PCR. (
  • Our Human IL-8 ELISA Kit is a sandwich ELISA intended for the quantitative determination of human IL-8 in cell culture supernates, serum and plasma (heparin, EDTA, citrate). (
  • Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response. (
  • It is believed that IL-8 acts as a proinflammatory mediator in conditions such as psoriasis and gingivitis. (
  • The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis. (
  • Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation. (
  • Recently, IL-8 signaling has been implicated in regulating the transcriptional activity of the androgen receptor, underpinning the transition to an androgen-independent proliferation of prostate cancer cells. (
  • Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. (
  • Conclusions We propose that high circulating IL-8 in human alcoholic hepatitis may cause pathogenic overzealous neutrophil activation, and therapeutic blockade via pepducins merits clinical study. (