A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Adherence of cells to surfaces or to other cells.
Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.
Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.
Granulomatous disorders affecting one or more sites in the respiratory tract.
Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Antibodies produced by a single clone of cells.
The level of governmental organization and function at the national or country-wide level.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Contamination of the air by tobacco smoke.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
A group of islands in the southwest central Pacific, divided into AMERICAN SAMOA and the INDEPENDENT STATE OF SAMOA (Western Samoa). First European contact was made in 1722 by Jacob Roggeveen, a Dutchman. In 1768 they were named Navigators Islands by Louis de Bougainville. The present name may derive from that of a local chieftain or from a local word meaning place of the moa, a now-extinct island bird. (From Webster's New Geographical Dictionary, 1988, p1061 & Room, Brewer's Dictionary of Names, 1992, p481)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Glucose in blood.
Experimental devices used in inhalation studies in which a person or animal is either partially or completely immersed in a chemically controlled atmosphere.
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Insulated enclosures in which temperature, humidity, and other environmental conditions can be regulated at levels optimal for growth, hatching, reproduction, or metabolic reactions.
A condition of decreased oxygen content at the cellular level.
Relatively complete absence of oxygen in one or more tissues.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.
Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Short fragments of DNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The vein which drains the foot and leg.
Two small peptide chains removed from the N-terminal segment of the beta chains of fibrinogen by the action of thrombin. Each peptide chain contains 20 amino acid residues. The removal of fibrinopeptides B is not required for coagulation.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.

Donor MHC and adhesion molecules in transplant arteriosclerosis. (1/5011)

Transplant-associated arteriosclerosis remains an obstacle to long-term graft survival. To determine the contribution to transplant arteriosclerosis of MHC and adhesion molecules from cells of the donor vasculature, we allografted carotid artery loops from six mutant mouse strains into immunocompetent CBA/CaJ recipients. The donor mice were deficient in either MHC I molecules or MHC II molecules, both MHC I and MHC II molecules, the adhesion molecule P-selectin, intercellular adhesion molecule (ICAM)-1, or both P-selectin and ICAM-1. Donor arteries in which ICAM-1, MHC II, or both MHC I and MHC II were absent showed reductions in neointima formation of 52%, 33%, and 38%, respectively, due primarily to a reduction in smooth muscle cell (SMC) accumulation. In P-selectin-deficient donor arteries, neointima formation did not differ from that in controls. In donor arteries lacking both P-selectin and ICAM-1, the size of the neointima was similar to that in those lacking ICAM-1 alone. In contrast, neointima formation increased by 52% in MHC I-deficient donor arteries. The number of CD4-positive T cells increased by 2.8-fold in MHC I-deficient arteries, and that of alpha-actin-positive SMCs by twofold. These observations indicate that ICAM-1 and MHC II molecules expressed in the donor vessel wall may promote transplant-associated arteriosclerosis. MHC I molecules expressed in the donor may have a protective effect.  (+info)

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. (2/5011)

Both chlamydial and human heat shock protein 60s (HSP 60), which colocalize in human atheroma, may contribute to inflammation during atherogenesis. We tested the hypothesis that chlamydial or human HSP 60 activates human endothelial cells (ECs), smooth muscle cells (SMCs), and monocyte-derived macrophages. We examined the expression of adhesion molecules such as endothelial-leukocyte adhesion molecule-1 (E-selectin), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), and the production of the proinflammatory cytokine interleukin-6 (IL-6). We also tested whether either HSP 60 induces nuclear factor-kappaB (NF-kappaB), which contributes to the gene expression of these molecules. Either chlamydial or human HSP 60 induced E-selectin, ICAM-1, and VCAM-1 expression on ECs similar to levels induced by Escherichia coli lipopolysaccharide (LPS). Each HSP 60 also significantly induced IL-6 production by ECs, SMCs, and macrophages to an extent similar to that induced by E. coli LPS, as assessed by enzyme-linked immunosorbent assay (ELISA). In ECs, either HSP 60 triggered activation of NF-kappaB complexes containing p65 and p50 Rel proteins. Heat treatment abolished all these effects, but did not alter the ability of E. coli LPS to induce these functions. Chlamydial and human HSP 60s therefore activate human vascular cell functions relevant to atherogenesis and lesional complications. These findings help to elucidate the mechanisms by which a chronic asymptomatic chlamydial infection might contribute to the pathophysiology of atheroma.  (+info)

Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. (3/5011)

ICAM-2-deficient mice exhibit prolonged accumulation of eosinophils in lung interstitium concomitant with a delayed increase in eosinophil numbers in the airway lumen during the development of allergic lung inflammation. The ICAM-2-dependent increased and prolonged accumulation of eosinophils in lung interstitium results in prolonged, heightened airway hyperresponsiveness. These findings reveal an essential role for ICAM-2 in the development of the inflammatory and respiratory components of allergic lung disease. This phenotype is caused by the lack of ICAM-2 expression on non-hematopoietic cells. ICAM-2 deficiency on endothelial cells causes reduced eosinophil transmigration in vitro. ICAM-2 is not essential for lymphocyte homing or the development of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduced.  (+info)

Invasion of human mucosal epithelial cells by Neisseria gonorrhoeae upregulates expression of intercellular adhesion molecule 1 (ICAM-1). (4/5011)

Infection of the mucosa by Neisseria gonorrhoeae involves adherence to and invasion of epithelial cells. Little is known, however, about the expression by mucosal epithelial cells of molecules that mediate cellular interactions between epithelial cells and neutrophils at the site of gonococcal infection. The aim of this study was to determine the expression of intercellular adhesion molecule 1 (ICAM-1) by epithelial cells during the process of gonococcal invasion. The highly invasive strain FA1090 and the poorly invasive strain MS11 were incubated with human endometrial adenocarcinoma (HEC-1-B) or human cervical carcinoma (ME-180) epithelial cells, after which ICAM-1 expression was measured by flow cytometry. After 15 h of infection with FA1090, expression of ICAM-1 increased 4.7- and 2.1-fold for HEC-1-B and ME-180 cells, respectively, whereas 15 h of infection of HEC-1-B cells with MS11 increased ICAM-1 expression only 1.6-fold. ICAM-1 expression was restricted to the cell surface, since no soluble ICAM-1 was detected. The distribution of staining was heterogeneous and mimicked that seen after treatment of HEC-1-B cells with the ICAM-1 agonist tumor necrosis factor alpha (TNF-alpha) in the absence of bacteria. PCR and dot blot analyses of ICAM-1 mRNA showed no change in levels over time in response to infection. Although TNF-alpha was produced by HEC-1-B cells after infection, the extent of ICAM-1 upregulation was not affected by neutralizing anti-TNF-alpha antiserum. Dual-fluorescence flow cytometry showed that the cells with the highest levels of ICAM-1 expression were cells with associated gonococci. We conclude that epithelial cells upregulate the expression of ICAM-1 in response to infection with invasive gonococci. On the mucosa, upregulation of ICAM-1 by infected epithelial cells may function to maintain neutrophils at the site of infection, thereby reducing further invasion of the mucosa by gonococci.  (+info)

Potent immunoregulatory effects of Salmonella typhi flagella on antigenic stimulation of human peripheral blood mononuclear cells. (5/5011)

A key function of monocytes/macrophages (Mphi) is to present antigens to T cells. However, upon interaction with bacteria, Mphi lose their ability to effectively present soluble antigens. This functional loss was associated with alterations in the expression of adhesion molecules and CD14 and a reduction in the uptake of soluble antigen. Recently, we have demonstrated that Salmonella typhi flagella (STF) markedly decrease CD14 expression and are potent inducers of proinflammatory cytokine production by human peripheral blood mononuclear cells (hPBMC). In order to determine whether S. typhi and soluble STF also alter the ability of Mphi to activate T cells to proliferate to antigens and mitogens, hPBMC were cultured in the presence of tetanus toxoid (TT) or phytohemagglutinin (PHA) and either killed whole-cell S. typhi or purified STF protein. Both whole-cell S. typhi and STF suppressed proliferation to PHA and TT. This decreased proliferation was not a result of increased Mphi production of nitric oxide, prostaglandin E2, or oxygen radicals or the release of interleukin-1beta, tumor necrosis factor alpha, interleukin-6, or interleukin-10 following exposure to STF. However, the ability to take up soluble antigen, as determined by fluorescein isothiocyanate-labeled dextran uptake, was reduced in cells cultured with STF. Moreover, there was a dramatic reduction in the expression of CD54 on Mphi after exposure to STF. These results indicate that whole-cell S. typhi and STF have the ability to alter in vitro proliferation to soluble antigens and mitogens by affecting Mphi function.  (+info)

Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. (6/5011)

Endothelial damage is characteristic of infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). Because Stx-mediated endothelial cell damage at the site of infection may lead to the characteristic hemorrhagic colitis of STEC infection, we compared the effects of Stx1 and Stx2 on primary and transformed human intestinal microvascular endothelial cells (HIMEC) to those on macrovascular endothelial cells from human saphenous vein (HSVEC). Adhesion molecule, interleukin-8 (IL-8), and Stx receptor expression, the effects of cytokine activation and Stx toxins on these responses, and Stx1 and Stx2 binding kinetics and bioactivity were measured. Adhesion molecule and IL-8 expression increased in activated HIMEC, but these responses were blunted in the presence of toxin, especially in the presence of Stx1. In contrast to HSVEC, unstimulated HIMEC constitutively expressed Stx receptor at high levels, bound large amounts of toxin, were highly sensitive to toxin, and were not further sensitized by cytokines. Although the binding capacities of HIMEC for Stx1 and Stx2 were comparable, the binding affinity of Stx1 to HIMEC was 50-fold greater than that of Stx2. Nonetheless, Stx2 was more toxic to HIMEC than an equivalent amount of Stx1. The decreased binding affinity and increased toxicity for HIMEC of Stx2 compared to those of Stx1 may be relevant to the preponderance of Stx2-producing STEC involved in the pathogenesis of hemorrhagic colitis and its systemic complications. The differences between primary and transformed HIMEC in these responses were negligible. We conclude that transformed HIMEC lines could represent a simple physiologically relevant model to study the role of Stx in the pathogenesis of hemorrhagic colitis.  (+info)

Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered. (7/5011)

It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells. Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction. However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect. Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules. However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28. Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid. Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.  (+info)

T lymphocyte adhesion mechanisms within inflamed human kidney: studies with a Stamper-Woodruff assay. (8/5011)

Renal inflammatory conditions are characterized by mononuclear cell recruitment to sites of inflammation. We have developed a modified Stamper-Woodruff assay system to analyze mechanisms of functional T cell adhesion to cryostat sections of renal biopsy material from patients with vasculitic glomerulonephritis (GN) and acute allograft rejection. Peripheral blood T cells adhered to intraglomerular, periglomerular, and tubulointerstitial regions of the cortex. Blocking monoclonal antibodies against tissue expressed ICAM-1, VCAM-1, and the CS-1 domain of fibronectin (CS-1Fn) differentially attenuated T cell adhesion. Glomerular adhesion in vasculitic GN and tubulointerstitial adhesion in acute rejection were particularly sensitive to both anti-ICAM-1 and anti-VCAM-1 antibodies, indicating a prominent role for ICAM-1 and VCAM-1 at glomerular sites in vasculitis and at tubulointerstitial sites in rejection. Furthermore, using KL/4 cells (LFA-1 expressing) and Jurkat cells (VLA-4 expressing), we demonstrated specific LFA-1/ICAM-1- and VLA-4/VCAM-1-mediated interactions within glomerular and tubulointerstitial compartments. Jurkat cells also adhered to VCAM-1-free sites, and binding was inhibitable by anti-CS-1Fn antibody, thereby demonstrating a role for VLA-4/fibronectin interactions especially at intraglomerular sites in acute rejection where VCAM-1 is notably absent. We therefore propose a prominent functional role for ICAM-1, VCAM-1, and CS-1 domain fibronectin in T cell recruitment to the inflamed kidney.  (+info)

Purpose Among cell adhesion molecules, serum degrees of intercellular adhesion molecule-1 and E-selectin are regarded as correlated with the metastatic potential of gastric cancer. in gastric cancers tissue and cultured gastric cancers cells were elevated, however, E-selectin in gastric cancers tissue and cells werent elevated. Among 157 gastric malignancy patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and experienced larger tumor FCRL5 size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-12 months survival than the negative group (54.9 vs. 85.9%, respectively). Conclusions Intercellular adhesion molecule-1 is usually overexpressed in gastric malignancy tissues and cultured gastric malignancy cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric ...
OBJECTIVE: To investigate the associations between markers of systemic and vascular inflammation, and indicators of vascular morphology and function. METHODS: In 59 apparently healthy individuals, we measured serum levels of highly sensitive C-reactive protein (hsCRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. Endothelium-dependent (EDV) and -independent (EIDV) vasodilatation was evaluated in the forearm by venous occlusion plethysmography and local infusions of methacholine and sodium nitroprussid. Endothelial function index (EFI) was expressed as the EDV/EIDV ratio. The intima-media thickness (IMT) of the common carotid artery was investigated with ultrasound (far wall). RESULTS: EFI was inversely related only to ICAM-1 (r=-0.31, P,0.02) by univariate analysis. This association remained significant after adjustment for age, sex, blood pressure, smoking and serum cholesterol. EFI did not relate to hsCRP, VCAM-1 or E-selectin. Neither ...
Intercellular adhesion molecule-1 (ICAM-1, CD54) is a ligand for the integrins lymphocyte function associated-1 (LFA-1, CD11a/CD18) and complement receptor-3 (Mac-1, CD11b/CD18) making it an important participant in many immune and inflammatory processes. Modified recombinant soluble ICAM-1 formed dimers. This result indicated that the ectodomain of ICAM-1 contains homophilic interaction sites. Soluble ICAM-1 dimers bind to solid-phase purified LFA-1 with high avidity (dissociation constant [Kd] = 8 nM) in contrast to soluble ICAM-1 monomers whose binding was not measurable. Cell surface ICAM-1 was found to be dimeric based on two distinct criteria. First, a monoclonal antibody specific for monomeric soluble ICAM-1, CA7, binds normal ICAM-1 poorly at the cell surface; this antibody, however, binds strongly to two mutant forms of ICAM-1 when expressed at the cell surface, thus identifying elements required for dimer formation. Second, chemical cross-linking of cell surface ICAM-1 on transfected cells and
The aim of this study was to analyse the potential roles of protein kinase enzymes in tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) induced expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on human umbilical vein endothelial cells (HUVEC). The authors observed a marked increase in ICAM-1 and VCAM-1 expression on HUVEC stimulated for 24 h by TNF-alpha (10 ng/ml) or IL-1 (20 ng/ml). Pre-treatment of HUVEC for 30 min with protein tyrosine kinase (PTK) inhibitors genistein and herbimycin A (10 micrograms/ml and 0.5 microgram/ml, respectively) before stimulation with IL-1 did not affect the expression of these molecules. Similar results were observed with respect to VCAM-1 expression on HUVEC stimulated by TNF-alpha. In contrast, pre-incubation of HUVEC with PTK inhibitors prior to the addition of TNF-alpha significantly enhanced subsequent expression of ICAM-1, although spontaneous expression of ICAM-1 on
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Background CD200 is a transmembrane protein expressed on multiple cell types (e.g. thymocytes, activated T cells, B cells, dendritic cells, and endothelial cells). It regulates antitumor immunity and its overexpression is associated with poor prognosis in chronic lymphocytic leukemia (CLL). A soluble variant of CD200 (sCD200) is detectable in human serum, and an elevated serum level was shown in patients with CLL.. Objective The aim of the study is to investigate the relationship between the levels of CD200 and clinical staging in patients with CLL.. Subjects and methods The study included 50 patients, divided into two groups. The patient group included 30 de-novo patients with CLL (18 men and 12 women), whose age ranged from 49 to 70 years with a mean±SD of 57.82±4.94 years. They were classified according to the modified Rai staging system into three classes: (a) low-risk patients, which included seven cases (stage 0); (b) intermediate-risk patients, which included eight cases (stages I and ...
Principal Investigator:WATANAVBE Hiroaki,渡辺 広昭, Project Period (FY):1993 - 1994, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Anesthesiology/Resuscitation studies
TY - JOUR. T1 - Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells. T2 - Evidence for diverse transcriptional responses. AU - Bender, Jeffrey R.. AU - Sadeghi, Mehran M.. AU - Watson, Cornelius. AU - Pfau, Steven. AU - Pardi, Ruggero. PY - 1994/4/26. Y1 - 1994/4/26. N2 - It is well accepted that the induction of endothelial cell (EC) adhesion molecules is a critical component in acute inflammatory responses as well as allogeneic interactions in vascularized allografts and, possibly, atherogenesis. The inflammatory triad of interleukin 1 (IL-1), tumor necrosis factor, and lipopolysaccharide are potent stimulators of the EC activation/adhesion molecules intercellular adhesion molecule 1 (ICAM-1), endothelial-leukocyte adhesion molecule 1 (ELAM-1), and vascular cell adhesion molecule 1 (VCAM-1). To address whether there exist differing thresholds to cytokine-mediated EC activation, we utilized a panel of genetically distinct human umbilical vein EC lines, ...
Albany, New York, August 9, 2017: Market Research Hub (MRH) has recently highlighted the pipeline landscape of Intercellular Adhesion Molecule 1 in a new report added to its repository, with a title of Intercellular Adhesion Molecule 1 (Major Group Rhinovirus Receptor or CD54 or ICAM1) - Pipeline Review, H2 2017. The main purpose of this study is to provide an assessment of the various pipeline targeted therapeutics, together with analysis by indications, stage of development, route of administration (RoA), mechanism of action (MoA) and molecule type. Through this analysis, the readers will gain strategically significant competitor information, analysis and key insights to frame effective R&D strategies.. Request Free Sample Report: http://www.marketresearchhub.com/enquiry.php?type=S&repid=1256874. Initially, this pipeline guide covers intercellular Adhesion Molecule 1 (ICAM-1) overview along with precise information on its therapeutic development. This section provides data on targeted ...
Fingerprint Dive into the research topics of Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells. Together they form a unique fingerprint. ...
1IAM: The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand.
1IAM: The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand.
TY - JOUR. T1 - Subcellular Localization of Intercellular Adhesion Molecule-5 (Telencephalin) in the Visual Cortex Is Not Developmentally Regulated in the Absence of Matrix Metalloproteinase-9. AU - Kelly, Emily A.. AU - Tremblay, Marie-Eve. AU - Gahmberg, Carl G.. AU - Tian, Li. AU - Majewska, Ania K.. PY - 2014. Y1 - 2014. KW - ICAM-5. KW - dendrite. KW - electron microscopy. KW - plasticity. KW - telencephalin. KW - MMP-9. KW - LONG-TERM POTENTIATION. KW - MATRIX METALLOPROTEINASES. KW - MEMBRANE GLYCOPROTEIN. KW - NEURONAL GLYCOPROTEIN. KW - LEUKOCYTE ADHESION. KW - RAT HIPPOCAMPUS. KW - BRAIN. KW - EXPRESSION. KW - EPHA4. KW - MICROGLIA. KW - 1182 Biochemistry, cell and molecular biology. U2 - 10.1002/cne.23440. DO - 10.1002/cne.23440. M3 - Article. VL - 522. SP - 676. EP - 688. JO - Journal of Comparative Neurology. JF - Journal of Comparative Neurology. SN - 0021-9967. IS - 3. ER - ...
OBJECTIVES: The objectives of this study were to examine the time course of the inflammatory response in acute coronary syndromes (ACS) and to assess the markers of inflammation and their relation to disease severity. METHODS: We prospectively studied 134 patients with ACS who survived for at least 30 months. The patients were divided into four groups: acute myocardial infarction (MI) with (n=54) or without (n=46) ST-segment elevation and unstable angina with (n=14) or without (n=20) increased risk. Plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6), secretory phospholipase A2 group IIA (sPLA2-IIA), and intercellular adhesion molecule-1 (ICAM-1) were measured on days 1 and 4 and after 3 and 30 months. RESULTS: The highest levels of CRP and sPLA2-IIA were seen on day 4 but for IL-6 on day 1. These three markers, but not ICAM-1, were significantly related to disease severity, CKMB, and ejection fraction. Patients in Killip class II-IV had higher levels than those in Killip class I. ...
Dive into the research topics of Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma. Together they form a unique fingerprint. ...
Intercellular Adhesion Molecule-1 information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
TY - JOUR. T1 - Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumonia. AU - Quasney, Michael W.. AU - Waterer, Grant W.. AU - Dahmer, Mary K.. AU - Turner, Dawn. AU - Zhang, Qing. AU - Cantor, Rita M.. AU - Wunderink, Richard G.. PY - 2002/3. Y1 - 2002/3. UR - http://www.scopus.com/inward/record.url?scp=0036129771&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0036129771&partnerID=8YFLogxK. U2 - 10.1378/chest.121.3_suppl.85S. DO - 10.1378/chest.121.3_suppl.85S. M3 - Article. C2 - 11893710. AN - SCOPUS:0036129771. VL - 121. SP - 85S-86S. JO - Chest. JF - Chest. SN - 0012-3692. IS - 3. ER - ...
A review about biomarkers for the investigation of vascular function and impairment in diabetes mellitus Giuseppe Derosa,1 Pamela Maffioli2 1Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2School in Experimental Medicine, University of Pavia, Pavia, Italy Abstract: The aim of this review was to analyze the main biomarkers of vascular function and impairment in patients with type 2 diabetes. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched. We concluded that proatherogenic adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and soluble E selectin) and inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α) were elevated in type 2 diabetes mellitus. Their increased expression and release contribute to the accelerated atherogenesis typical of these patients. For these
Materials. Peridinin chlorophyll protein-labeled anti-HLA-DR, FITC-conjugated anti-CD80, phycoerythrin (PE)-conjugated anti-CD86, PE-conjugated anti-CD40, and FITC-labeled anti-CD8 were purchased from BD Biosciences PharMingen (Chicago, IL). FITC-conjugated anti-HLA-A2 monoclonal antibody (clone BB7.2) was from Serotec Ltd. (Oxford, United Kingdom). Anti-human CEA (CE05) was from Neomarker (Fremont, CA). Anti-HSP27 (F-4), anti-HSP40 (C-20), anti-HSP60 (H-1), anti-HSP70 (K-20), anti-Hsc70 (B6), anti-intercellular adhesion molecule-1 (C-19), anti-B7.1 (N-20), anti-B7.2 (C-19), anti-transferrin receptor (K-20), and anti-lysosome-associated membrane glycoprotein-3 were from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). Anti-MHC-I (HC10) was from Roswell Park Cancer Institute (Buffalo, NY). Horseradish peroxidase-coupled secondary antibodies were from Jackson ImmunoResearch (West Grove, PA). Recombinant mouse interleukin (IL)-2 and recombinant human IL-2 were commercially obtained from Sigma (St. ...
C-reactive protein (CRP) levels were 29% lower among those in the highest quintile of total (n-3) fatty acids, compared with the lowest quintile; interleukin-6 (IL-6) levels were 23% lower, E-selectin levels 10% lower, soluble intracellular adhesion molecule (sICAM-1) levels 7% lower, and soluble vascular adhesion molecule (sVCAM-1) levels 8% lower ...
|p|ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes.|/p||p|When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.|/p|
Results Among 106 women followed over 565 patient-years we identified 4 CV events (1 fatal stroke, 2 myocardial infarction and 1 unstable angina), which contributed to an incidence rate of 7 per 1000 person-years (95%CI 2.0-13.9). Patients who developed CV events were older, but the distribution of other traditional CV risk factors was otherwise similar in both groups. Also, corticosteroid dosage and proportion of patients with carotid atherosclerotic plaques was higher in those with CV events (Table 1). Erythrocyte sedimentation rate (ESR) (HR 1.036; 95%CI 1.005-1.067) and soluble intercellular adhesion molecule-1 (sICAM-1) serum levels (HR 1.002; 95%CI 1.000-1.003) significantly contributed to CV events. These results remained significant after adjusting for patients age. ...
The major findings of this study are as follows: (1) Adeno-virus-mediated gene transfer of c-jun and c-fos can effectively and specifically establish an experimental model for AP-1 activation in human ECs, (2) AP-1 activation can directly induce gene expression of an adhesion molecule, ICAM-1, and a chemokine, MCP-1, which are considered to be the molecular markers of EC activation and are implicated in various EC pathological processes, from inflammation to atherogenesis, (3) The AP-1-mediated induction of ICAM-1 can occur independently of activation of the NF-κB pathway.. AP-1 transcription factors are formed through dimerization between the members of the Fos and Jun families.27 Recent studies have suggested AP-1 to be an important regulator in endothelial function and pathological processes. First, the AP-1 binding motif has been identified as a recurrent sequence in the promoters of many genes biologically significant in the conversion of ECs into a proinflammatory or procoagulant status, ...
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue ...
Soluble intercellular adhesion molecule 1 was associated with an increased risk for MI in healthy men. The idea that an inflammatory process may be responsible for the initiation and promotion of atherosclerosis is not new. As early as 1856, Virchow (1) hypothesized a role for inflammation in atherosclerosis. The importance of the foam cell in the pathophysiology of atherosclerosis was shown in the early 1960s, and subsequent technological advances allowed the identification of macrophages, T-lymphocytes, and smooth muscle cells as the primary cellular constituents of early and advanced lesions of atherosclerosis. The presence of macrophages and T-lymphocytes in the atherosclerotic lesion strongly suggested inflammation as a key factor in the development of atherosclerosis. In vitro and animal studies have shown that endothelial and smooth muscle cells present membrane adhesion molecules that act as monocyte receptors when stimulated by cytokines, thrombin, and oxidized LDL cholesterol. Membrane ...
article{bf2f68b0-78f4-408f-aaba-1ab63bdb5a32, author = {Olanders, Knut and Börjesson, Anna and Sun, Z W and Andersson, R}, issn = {1502-7708}, language = {eng}, number = {6}, pages = {618--625}, publisher = {Taylor & Francis}, series = {Scandinavian Journal of Gastroenterology}, title = {Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats.}, url = {http://dx.doi.org/10.1080/00365520310002201}, volume = {38}, year = {2003 ...
Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molec …
The adhesive function of integrins is regulated through cytoplasmic signaling induced by several stimuli, whose process is designated inside-out signaling. A large number of leukocytes are rapidly recruited to the sites of inflammation where they form an essential component of the response to infe …
ICAM-4 is a red cell intercellular adhesion molecule. Cell transfectants expressing various integrins were used to demonstrate that integrins alpha-L-beta-2, alpha-M-beta-2, and alpha-IIb-beta-3 bind specifically and dose dependently to the recombinant ICAM-4-Fc protein. Cell surface ICAM-4 interacts with the cell surface alpha-V-beta-3 integrin (Hermand et al. 2004) ...
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Sigma-Aldrich offers abstracts and full-text articles by [Ana Estecha, Noemí Aguilera-Montilla, Paloma Sánchez-Mateos, Amaya Puig-Kröger].
ICAM2 antibody [CBRIC2/2] (PE) (intercellular adhesion molecule 2) for FACS. Anti-ICAM2 mAb (GTX43223) is tested in Human samples. 100% Ab-Assurance.
Supplementary MaterialsSupplementary methods and figures. looked into the PTPN13 implications on cell aggressiveness using wound Boyden and curing chamber assays, on intercellular adhesion using videomicroscopy, cell aggregation immunofluorescence and assay. Outcomes: The advancement, development and invasiveness of breasts tumors were highly elevated by deletion from the PTPN13 phosphatase activity in transgenic mice. We noticed that PTPN13 phosphatase activity must inhibit cell motility and invasion in the MDA-MB-231 cell series overexpressing PTPN13. was defined as among the three most regularly mutated PTPs plus some of the mutations had been also within tumors from various other tissue 21. The gene is situated on chromosome 4q21, an area removed in ovarian, liver organ and lung cancers 22. Furthermore, mRNA expression can be an unbiased prognostic marker of elevated overall success in breast cancer tumor 23, in hepatocellular carcinoma 24, lung cancers 16 and in high quality serous ovarian ...
Complete information for ICAM1 gene (Protein Coding), Intercellular Adhesion Molecule 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to…
CD54 (ICAM-1), PerCP-eFluor™ 710, clone: HA58, eBioscience™ 100 Tests; PerCP-eFluor™ 710 CD54 (ICAM-1), PerCP-eFluor™ 710, clone: HA58,...
ICAM3兔单克隆抗体[EPR3994](ab109405)可与人样本反应并经WB, IP, IHC, ICC, Flow Cyt实验严格验证,被1篇文献引用。所有产品均提供质保服务,中国75%以上现货。
ICAM3兔单克隆抗体[EPR3995](ab108618)可与小鼠, 人样本反应并经WB, IP, ICC, Flow Cyt实验严格验证。所有产品均提供质保服务,中国75%以上现货。
トを用いた.方法:ラット肺を灌流固定後,光学顕微鏡および電子顕微鏡試料を作製した.ラット血管内皮細胞に発現する蛋白(ICAM2,ポドカリキシンおよびI-10抗原)について肺での発現を免疫組織化学とイムノブロット法にて解析した.結果:胎仔期,新生仔期から成獣の肺においてICAM2とポドカリキシンはすべての血管内皮細胞の表面に均一に発現を認め,内皮細胞の良いマーカーとなることを確認した.新規 … ...
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Renal sympathetic denervation (RSD) is a treatment option for patients with resistant arterial hypertension, but in some patients it is not successful. Predictive parameters on the success of RSD remain unknown. The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. We evaluated whether sFLT-1, ICAM-1, and VCAM-1 are predictive markers for blood pressure reduction after RSD. Consecutive patients (n=55) undergoing renal denervation were included. Venous serum samples for measurement of sFlt-1, ICAM-1, and VCAM-1 were collected before and 6 months after RSD. A therapeutic response was defined as an office systolic blood pressure reduction of ,10 mm Hg 6 months after RSD. A significant mean office systolic blood pressure reduction of 31.2 mm Hg was observed in 46 patients 6 months after RSD. Nine ...
Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. The in vitro expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on biliary epithelial cells was studied in response to tumour necrosis factor-alpha (0-500 U/ml), interferon-gamma (0-500 U/ml), and interleukin-1 (0-5 U/ml) by immunohistochemical staining and a semiquantitative scoring system validated by spectrophotometry and previously validated by laser confocal microscopy. The non-stimulated expression of intercellular adhesion molecule-1 and HLA class II was higher on cells derived from the primary biliary cirrhosis liver than on cells from normal liver, a difference not seen with HLA class I expression. A statistically significant increase in intercellular adhesion molecule-1 expression was seen with all three cytokines in cells derived from both primary biliary cirrhosis and normal liver. ...
TY - JOUR. T1 - Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia. AU - Poria, Rahul B.. AU - Norenberg, Jeffrey P.. AU - Anderson, Tamara L.. AU - Erion, Jack. AU - Wagner, Carston R.. AU - Arterburn, Jeffrey B.. AU - Larson, Richard S.. PY - 2006/11/20. Y1 - 2006/11/20. N2 - Objective: Leukocyte function-associated antigen-1 (LFA-1) is constitutively expressed on leukocytes, including overexpression on lymphomas and leukemias. We have developed a derivative of BIRT 377, an allosteric inhibitor of LFA-1, which may be chemically tagged without affecting binding. In this study, we modified this derivative, (R)-1-(4-aminobutyl)-5-(4-bromobenzyl) -3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione (butylamino-NorBIRT), and demonstrated its potential as a noninvasive imaging agent. Methods: Specific binding of fluorescein-labeled butylamino-NorBIRT to both human and murine cells was demonstrated using ...
We have expressed in Escherichia coli the two N-terminal immunoglobulin (Ig)-like domains of the intercellular adhesion molecule 1 (ICAM-1). The first 188 residues of ICAM-1 were expressed with an N-terminal methionine (MP188) or as a maltose-binding fusion protein which was cleaved with factor Xa (XP188). After refolding, both MP188 and XP188 were active in binding to the leukocyte integrin lymphocyte function-associated antigen 1, which has previously been shown to bind to the N-terminal Ig domain of ICAM-1. The major group of rhinoviruses and malaria-infected erythrocytes bind to distinct sites within the first Ig-like domain of ICAM-1. Both MP188 and XP188 bound to malaria-infected erythrocytes; however, only XP188 inhibited human rhinovirus plaque formation. A product (MdQ1P188) with the initiation methionine fused to residue 2, i.e., with glutamine 1 deleted, inhibited plaque formation. MdQ1P188 was able to induce a conformational change of the virus capsid as shown by conversion of 149S ...
BACKGROUND: Consistent difference in graft survival after renal transplantation has been shown when cadaveric transplants are compared to the living related donor situation, in favor of the latter. Recently, evidence has been put forward that brain death has significant effects on the donor organ quality. In this study, we aimed to assess the relation between brain death-induced hemodynamic instability in combination with the duration of brain death on the function and immunogenicity status of potential donor kidneys. METHODS: In Wistar rats, short-term (1 hour) or long-term (6 hours) brain death in the presence or absence of hemodynamic stability was applied. Sham-operated rats served as controls (1 hour and 6 hours). Organ function was studied by monitoring serum creatinine, lactate dehydrogenase (LDH), lactate, and total protein content. Expression of cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)] and the influx of leukocytes in the
The I domain of lymphocyte function-associated antigen (LFA)-1 contains an intercellular adhesion molecule (ICAM)-1 and ICAM-3 binding site, but the relationship of this site to regulated adhesion is unknown. To study the adhesive properties of the LFA-1 I domain, we stably expressed a GPI-anchored form of this I domain (I-GPI) on the surface of baby hamster kidney cells. I-GPI cells bound soluble ICAM-1 (sICAM-1) with a low avidity and affinity. Flow cell experiments demonstrated a specific rolling interaction of I-GPI cells on bilayers containing purified full length ICAM-1 or ICAM-3. The LFA-1 activating antibody MEM-83, or its Fab fragment, decreased the rolling velocity of I-GPI cells on ICAM-1-containing membranes. In contrast, the interaction of I-GPI cells with ICAM-3 was blocked by MEM-83. Rolling of I-GPI cells was dependent on the presence of Mg2+. Mn2+ only partially substituted for Mg2+, giving rise to a small fraction of rolling cells and increased rolling velocity. This suggests that the
TY - JOUR. T1 - Prevalence of the K469E polymorphism of intercellular adhesion molecule 1 gene in Italian patients with inflammatory bowel disease. AU - Papa, A.. AU - Pola, R.. AU - Flex, A.. AU - Danese, S.. AU - Armuzzi, A.. AU - Gaetani, E.. AU - Guidi, L.. AU - De Vitis, I.. AU - Urgesi, R.. AU - Grillo, A.. AU - Serricchio, M.. AU - Proia, A. S.. AU - Fedeli, G.. AU - Gasbarrini, G.. AU - Pola, P.. AU - Gasbarrini, A.. PY - 2004/8. Y1 - 2004/8. N2 - Background. Intercellular adhesion molecule 1 plays an important role in the recruitment of leucocytes at sites of inflammation and is up-regulated in intestinal mucosa of inflammatory bowel disease. Intercellular adhesion molecule 1 gene lies on chromosome 19p13, implicated in determining susceptibility to inflammatory bowel disease. Recently, the polymorphism K469E of intercellular adhesion molecule 1 gene has been identified. Aim. To assess the potential association of this polymorphism with inflammatory bowel disease. Patients. A total of ...
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Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an immunosuppressant by binding to CD11a but was ...
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[1]. CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.. Efalizumab acts as an immunosuppressant by binding to ...
Signaling through the leukocyte function-associated antigen 1 (LFA-1) molecule has previously been shown to induce homotypic aggregation in T cells and to induce cytoskeletal changes in T lymphoma cells. In this study we describe the induction of a d
The purpose of this study was to investigate the expression of intercellular adhesion molecule-1 (ICAM-1) in umbilical vascular of pregnant women with gestational diabetes mellitus (GDM) and the clinical significance. A total of 103 pregnant women with GDM were selected in the First Hospital of Lanzhou University and the Second Affiliated Hospital of Xian Jiaotong University from January 2016 to December 2016 as GDM group. At the same time, 106 normal pregnant women were selected as control group. i) General information of the two groups of pregnant women including age, gestational age, gravida, parity, BMI, systolic blood pressure and diastolic blood pressure were compared; ii) the laboratory indicators of the two groups of pregnant women including fasting blood glucose, glycosylated hemoglobin (HbA1c), umbilical cord arterial pH, partial pressure of oxygen (pO2) and carbon dioxide (pCO2) in umbilical artery were compared; iii) expression of ICAM-1 in umbilical vascular was detected by ...
The cell-surface glycoprotein vascular cell adhesion molecule-1 (VCAM-1; ref. 1) mediates intercellular adhesion by specific binding to the integrin very-late antigen-4 (VLA-4, alpha 4 beta 1; ref. 3). VCAM-1, with the intercellular adhesion molecules ICAM-1, ICAM-2, ICAM-3 and the mucosal vascular addressin MAd-CAM-1, forms an integrin-binding subgroup of the immunoglobulin superfamily. In addition to their clinical relevance in inflammation, these molecules act as cellular receptors for viral and parasitic agents. The predominant form of VCAM-1 in vivo has an amino-terminal extracellular region comprising seven immunoglobulin-like domains. Functional studies have identified a conserved integrin-binding motif in domains 1 and 4, variants of which are present in the N-terminal domain of all members of the immunoglobulin superfamily subgroup. We report here the crystal structure of a VLA-4-binding fragment composed of the first two domains of VCAM-1. The integrin-binding motif (Q38IDSPL) is highly
Results. Concentrations of soluble P-Selectin were greatest in cord blood samples obtained from all infants and were markedly reduced on day of life 1, regardless of the subsequent development of BPD. In serum samples obtained from cord blood and on days of life 1 and 3, soluble E-Selectin levels were higher in infants that developed BPD than in infants that did not develop BPD. In addition, the highest concentrations of soluble E-Selectin in serum samples from cord blood and on day of life 1 were associated with the development of stage 3 or 4 BPD. Soluble intercellular adhesion molecule-1 concentrations were higher on days of life 3 and 7 in the infants that went on to develop BPD than in those that did not. ...
During the allergic reaction mucosal T cells are activated and a local increase in numbers occurs. In peripheral blood, a concomitant T cell activation and switch towards memory phenotype appears. E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 were studied in nasal mucosal biopsies taken during a time-course provocation study, including patients with seasonal allergic rhinitis and healthy controls. Allergic patients were also studied during the natural pollen season with particular attention to the influence of local corticosteroid treatment. Before provocation allergic patients and controls did not differ concerning the expression of endothelial adhesion molecules. However, the epithelial ICAM-1 expression was increased among allergics (P , 0.05). Repetitive allergen provocation induces an increased endothelial expression of VCAM-1 in allergic patients (P , 0.01). Similarly, VCAM-1 expression was increased during the natural pollen season (P , ...
TY - JOUR. T1 - Intercellular adhesion molecule inhibitors as potential therapy for refractory uveitic macular edema. AU - Wang, Jianmin. AU - Ibrahim, Mohamed. AU - Turkcuoglu, Peykan. AU - Hatef, Elham. AU - Khwaja, Afsheen. AU - Channa, Roomasa. AU - Do, Diana V. AU - Nguyen, Quan Dong. PY - 2010/10/1. Y1 - 2010/10/1. N2 - Purpose: To describe the bioactivity of an intercellular adhesion molecule inhibitor (efalizumab) in a patient with refractory uveitic macular edema. Methods: A 55-year-old man presented with idiopathic autoimmune uveitis and associated macular edema, which could not be controlled by regional and systemic corticosteroid and selected immunomodulatory therapy. Efalizumab was administered as subcutaneous injections. Results: After 37 weekly injections of efalizumab, the uveitic macular edema was successfully eliminated. Six months following discontinuation of efalizumab, there were no signs of recurrent inflammation. Conclusion: Further investigation of the role of ...
TY - JOUR. T1 - Role of cellular adhesion molecules in HIV type 1 infection and their impact on virus neutralization. AU - Hioe, C. E.. AU - Bastiani, L.. AU - Hildreth, James. AU - Zolla-Pazner, S.. PY - 1998. Y1 - 1998. N2 - While CD4 and several chemokine receptors are the principal receptors for human immunodeficiency virus type 1 (HIV-1) viruses, other cell membrane proteins also play a role in HIV-1 infection. A large array of host cell- derived membrane proteins, including adhesion molecules, are incorporated into the envelope of HIV-1 virions, and the profile of host cell proteins acquired by the virus depends on the cells used to propagate the virus. The major leukocyte adhesion molecules, such as leukocyte-function associated antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and CD44, retain their biological functions when expressed on the virion surface, and have been shown to increase virus-cell interaction, enhance virus infectivity, and extend the host cell range of ...
Sigma-Aldrich offers abstracts and full-text articles by [G Liu, J T Link, Z Pei, E B Reilly, S Leitza, B Nguyen, K C Marsh, G F Okasinski, T W von Geldern, M Ormes, K Fowler, M Gallatin].
Clone REA378 recognizes the human CD11a antigen, a single-pass type I membrane protein also known as integrin α-L (ITGAL). Integrins are heterodimeric adhesion molecules comprised of α- and β-subunits that participate in immune cell interactions as well as in immune cell-extracellular matrix interactions. CD11a combines with CD18 (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 is a receptor for CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), and CD242 (ICAM-4). It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T cell-mediated killing, and antibody dependent killing by granulocytes and monocytes. Interactions between LFA-1 and CD54 (ICAM-1) play a critical role in T cell-B cell collaboration. Additional information: Clone REA378 displays negligible binding to Fc receptors. - Belgique
Clone REA378 recognizes the human CD11a antigen, a single-pass type I membrane protein also known as integrin α-L (ITGAL). Integrins are heterodimeric adhesion molecules comprised of α- and β-subunits that participate in immune cell interactions as well as in immune cell-extracellular matrix interactions. CD11a combines with CD18 (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 is a receptor for CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), and CD242 (ICAM-4). It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T cell-mediated killing, and antibody dependent killing by granulocytes and monocytes. Interactions between LFA-1 and CD54 (ICAM-1) play a critical role in T cell-B cell collaboration. Additional information: Clone REA378 displays negligible binding to Fc receptors. - Danmark
TY - JOUR. T1 - Interleukin-18/interferon-γ-inducing factor, a novel cytokine, up- regulates ICAM-1 (CD54) expression in KG-1 cells. AU - Kohka, Hideo. AU - Yoshino, Tadashi. AU - Iwagaki, Hiromi. AU - Sakuma, Isao. AU - Tanimoto, Tadao. AU - Matsuo, Yosinobu. AU - Kurimoto, Masashi. AU - Orita, Kunzo. AU - Akagi, Tadaatsu. AU - Tanaka, Noriaki. PY - 1998/10. Y1 - 1998/10. N2 - Intercellular adhesion molecule-1 (ICAM-1, CD54) is a membrane glycoprotein and a member of the immunoglobulin superfamily. It plays a central role in cell to cell-mediated immune responses and is a ligand for leukocyte function-associated antigen-1 (LFA-1). We report here that a newly discovered cytokine, interferon-γ-inducing factor (IGIF) [H. Okamura et al. (1995) Nature 378, 88] recently proposed to be designated as IL-18, selectively up-regulates ICAM-1 expression in KG-1 cells, a human myelomonocytic cell line, in which IL-18 also enhances interferon-γ production. IL-18 induced heterotypic aggregation between ...
Asthma is a chronic disease that is particularly common in children. The association between polymorphisms of the gene encoding intercellular adhesion molecule 1 (ICAM1) and gene-environment interactions with childhood asthma has not been fully investigated. A cross-sectional study was undertaken to investigate these associations among children in Taiwan. The effects of two functional single-nucleotide polymorphisms (SNPs) of ICAM1, rs5491 (K56M) and rs5498 (K469E), and exposure to environmental tobacco smoke (ETS) were studied. Two hundred and eighteen asthmatic and 877 nonasthmatic children were recruited from elementary schools. It was found that the genetic effect of each SNP was modified by the other SNP and by exposure to ETS. The risk of asthma was higher for children carrying the rs5491 AT or TT genotypes and the rs5498 GG genotype (odds ratio = 1.68, 95% confidence interval 1.09-2.59) than for those with the rs5491 AA and rs5498 AA or AG genotypes (the reference group). The risk for the other
While those in the ADF group often compensated for some of their lost calories when they were allowed to eat, they did not compensate for them all. Overall, they experienced a mean caloric restriction of around 35% and lost an average of 7.7 pounds during the 4-week trial.. There were health benefits, as well. The participants in the ADF group had reduced levels of soluble intercellular adhesion molecule-1, a marker linked to inflammation and age-related disease.. They also had lower levels of the thyroid hormone triiodothyronine, without experiencing any problems with thyroid function. Previous research has associated lowered levels of this hormone with longevity.. Additionally, the ADF group had lower levels of cholesterol and reduced trunk, or belly, fat. They also had some restriction in amino acids, which research in rodents suggests may extend the lifespan.. Furthermore, the ADF group experienced an upregulation in ketone bodies, which researchers consider a health benefit, on both the ...
Lifitegrast is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Buy Integrin inhibitor Lifitegrast from AbMole BioScience.
Cell adhesion is of utmost importance in normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin, TLN) is a member of the ICAM family of adhesion proteins. As a novel cell adhesion molecule, ICAM-5 shares many structural similarities with the other members of IgSF, especially the ICAM subgroup; however, ICAM-5 has several unique properties compared to the other ICAMs. With its nine extracellular Ig domains, ICAM-5 is the largest member of ICAM subgroup identified so far. Therefore, it is much more complex than the other ICAMs. The expression of ICAM-5 is confined to the telencephalic neurons of the central nervous system whereas all the other ICAM members are expressed mostly by cells in the immune and blood systems. The developmental appearance of ICAM-5 parallels the time of dendritic elongation and branching, and synapse formation in the telencephalon. As a somatodendrite-specific adhesion molecule, ICAM-5 not only participates in immune-nervous system
Figure 1. Central role of tissue factor (TF) in the interplay between coagulation and inflammation. During injury or infection, circulating monocytes (M) and subendothelial cells (eg, smooth muscle cells, SMC) are activated by reactive oxygen species (ROS), cytokines or endotoxin (LPS), and damage-associated molecular patterns (DAMPs) via pathogen recognition receptors, such as Toll-like receptors (TLRs). TF is exposed to the blood, sustained through the release of proinflammatory cytokines, chemokines, and inflammatory/procoagulant microparticles (MPs) by leukocytes, platelets, endothelial cells, and perivascular cells. TF triggers the generation of factor VIIa, factor Xa, and thrombin (IIa) which activate platelets and induce protease-activated receptor (PAR)-mediated signaling, with release of more inflammatory cytokines, upregulation of leukocyte adhesion molecules (intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1]), and suppression of vasculoprotective ...
Vascular cell adhesion molecule-1 (VCAM-1) is induced on endothelial cells by inflammatory cytokines, and binds mononuclear leukocytes through the integrin very late antigen-4 (VLA-4) (alpha 4 beta 1). This adhesion pathway has been implicated in a diverse group of physiological and pathological processes, including B cell development, leukocyte activation and recruitment to sites of inflammation, atherosclerosis, and tumor cell metastasis. The major form of VCAM-1 (VCAM-7D) has seven extracellular immunoglobulin (Ig)-like domains, of which the three NH2-terminal domains (domains 1-3) are similar in amino acid sequence to domains 4-6. By functional analysis of VCAM-7D relative to VCAM-6D (a minor 6-domain form of VCAM-1 in which domain 4 is deleted because of alternative splicing), and chimeric constructs between VCAM-1 and its structural relative intercellular adhesion molecule-1 (ICAM-1), we show that either the first or the homologous fourth domain of VCAM-1 is required for VLA-4-dependent ...
Provide insight into the relationship between markers of inflammation [specifically, free and total serum matrix metalloproteinase-1(MMP-1), free tissue inhibitor of metalloproteinase 1 (TIMP1), intercellular adhesion molecule-1 (ICAM), vascular cellular adhesion molecule (VCAM), P-selectin, von Willebrand factor (vWf), interleukin-6 (IL-6), endothelin 1, VEGF, NFkβ, TGF-β, IGF-1 and high-sensitivity C reactive protein (hs CRP)] and endothelial function; and insight into the changes in these markers in response to treatment with an AGE cross-link breaker (alagebrium ...
Infusions of apolipoprotein (apoA-I) in the lipid-free or lipid-associated form inhibit acute vascular inflammation in rabbits. Here, we investigate how these infusions affect endogenous HDL distribution and whether they enhance the anti-inflammatory capacity of the total HDL fraction. Rabbits (n = 3/group) were infused with saline or with 125I-labelled apoA-I (8mg/kg) in the lipid-free form or as a constituent of discoidal reconstituted HDL (rHDL). Serial blood samples were collected at 1-360 min post-infusion. Plasma was isolated and subjected to 2-D gel electrophoresis. Distributions of endogenous apoA-I and 125I-labelled apoA-I were determined by immunoblotting and phosphorimaging, respectively. HDL were ultracentrifugally isolated from plasma at 5 and at 360 min post-infusion and their anti-inflammatory capacity was assessed by quantitating vascular cell adhesion molecule-1(VCAM-1) and intercellular adhesion molecule-1(ICAM-1) protein expression in TNF-α-activated human coronary artery ...
Lymphocyte function associated antigen 1 (LFA-1) is a heterodimer, composed of an α L-chain and a β 2-chain. The I-domain is inserted in the ctL-chain and contains a binding site for ICAM-1. To study the adhesive interaction between the I-domain and ICAM-I, we constructed a GPIanchored form of the I-domain and expressed it stabily in BHK-cells. In contrast to the whole LFA-1 molecule (Kd=8nM), no interaction between soluble ICAM-1 dimers and I-domain expressing cells could be detected, suggesting that the ICAM-1/I-domain interaction is of low affinity (Kd|33||M). In flow cell experiments the I-domain expressing cells rolled on glass supported planar bilayers containing ICAM-1. Rolling was not caused by an uprooting of the GPI-linked protein, since BHK-cells expressing GPI-anchored ICAM-1 attached stabily to bilayers containing purified LFA-1. The interaction between ICAM-1 and the I-domain is dependent on divalent cations and is blocked by the LFA-1
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We measured LIGHT levels in RA synovial fluids (SF) by ELISA, and compared them with those in osteoarthritis (OA) SF. Levels of LIGHT and its receptors in RA-FLS and synovium were assessed using real-time quantitative polymerase chain reaction (PCR). RA-FLS proliferation was examined by a bromodeoxyuridine assay. Expression of intercellular adhesion molecule-1 (ICAM-1) and several chemokines, such as interleukin 8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1α (MIP-1α), was examined by real-time quantitative PCR, ELISA, and flow cytometry. The effects of LIGHT on nuclear factor-κB (NF-κB) activation were investigated using immunofluorescence and Western blotting.. ...
A sandwich ELISA kit for quantitative measurement of Rat ICAM-2/CD102 (Intercellular Adhesion Molecule 2) in samples from Serum, Plasma, Cell supernatant
Lifitegrast is a non-steroidal, small molecule, integrin antagonist that inhibits lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18), which is being
Our laboratory had previously developed a method for laboratory-directed evolution of proteins, called Codon-shuffling. The potential of this method to create stand-alone de novo protein/peptide libraries, for their eventual use as antibacterial and drug-like entities has since been realised. Our laboratory has recently discovered a completely de novo protein M5, that was able to disrupt the ICAM-1 dimer formation in vivo. The presence of ICAM-1 (Intercellular adhesion molecule) is crucial for the progression of diseases like tuberculosis, HIV, and malaria. It was shown that M5 is able to block the entry of P. falciparum into red blood cells by almost 80%. Not only has this discovery opened avenues to study the role of ICAM-1 or ICAM-like molecules in the invasion process, the drug-like potential of M5, or peptidomimetics based on M5, is also being explored ...
We show here that Egfl7 is a natural repressor of endothelial cell activation. It inhibits the expression of endothelial adhesion molecules and consequently reduces the adhesion of lymphocytes onto the endothelium. When placed in a tumor context, these effects result in an increased escape from immunity and a more rapid tumor growth.. The few previous studies that have described the expression of Egfl7 in human cancers all suggested that Egfl7 could promote tumor growth and metastasis (18-20), but no experimental study had addressed the direct role of Egfl7 in tumor development. Here, the results obtained using 2 independent tumor models and mouse genetic backgrounds validate this initial hypothesis made on clinical observations. Furthermore, overexpressing Egfl7 in experimental tumors allowed us to understand its functions in more detail. Egfl7 is not an oncogene as it does not confer per se intrinsic proliferative or invasive properties to lung or breast tumor cells in vitro. In vivo, Egfl7 ...
V-CAM protocol: chemotherapy protocol consisting of above cpds; do not confuse with VASCULAR CELL ADHESION MOLECULE-1 which is abbreviated VCAM-1
has likely a key role in regulating recycling through the RAB11A-dependent perinuclear recycling compartment, and links the regulation of adherens junctions to recycling to allow dynamic modulation of intercellular adhesion ...
News Analysis The Rising Research Profile of 23andMe An exploration of the genetics of earlobe attachment is just the latest collaborative research project to come out of the personal genetic testing company.. ...
Molecular cloning of murine intercellular adhesion molecule (ICAM-1). The EMBO Journal, 8(10), pp.2889-2896. Takei, F., ... Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion ... Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions. The Journal ... Immunological Reviews, 155(1), pp.67-77. Halim, T., Krauß, R., Sun, A. and Takei, F., 2012. Lung Natural Helper Cells Are a ...
Stimulation of IL-8 production and intercellular adhesion molecule-1 expression". J. Immunol. 156 (1): 275-83. PMID 8598474. ... and cell adhesion disruption". Biochemistry. 37 (8): 2291-8. doi:10.1021/bi972119z. PMID 9485375. Pereira PJ, Bergner A, Macedo ... Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. Beta tryptases appear to ... 1477 (1-2): 75-89. doi:10.1016/s0167-4838(99)00265-4. PMID 10708850. Kam CM, Hudig D, Powers JC (2000). "Granzymes (lymphocyte ...
"Syncytiotrophoblast intercellular adhesion molecule-1 expression in placental villitis of unknown cause". American Journal of ... Syncytiotrophoblasts can be made to exhibit adhesion molecules (intracellular adhesion molecule 1, E-selectin) in VUE, although ... in normal conditions adhesion molecules are not expressed. Maternal lymphocytes can enter the foetal stroma by passing the ... 33 (1): 54-59. doi:10.1111/j.1600-0897.1995.tb01138.x. Redline RW, Patterson P (1993). "Villitis of unknown etiology is ...
Springer is best known for his pioneering work in discovering the first integrins and intercellular adhesion molecules (ICAMs) ... "A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1". J Immunol. 137 (4): 1270-4. PMID 3525675.CS1 maint: uses ... known as selective adhesion molecule inhibitors, to treat autoimmune diseases. In recent years, Springer's research interest ... and elucidating how these cell adhesion molecules function in the immune system. His innovative use of monoclonal antibodies in ...
Burton J, Goldman CK, Rao P, Moos M, Waldmann TA (September 1990). "Association of intercellular adhesion molecule 1 with the ... 167 (1): 1-5. doi:10.4049/jimmunol.167.1.1. PMID 11418623. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi ... 13 (1): 27-40. doi:10.1016/S1359-6101(01)00023-5. PMID 11750878. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, ... 5 (1): 23-34. PMID 8049354. Markiewicz S, Subtil A, Dautry-Varsat A, Fischer A, de Saint Basile G (May 1994). "Detection of ...
... a link with soluble intercellular adhesion molecule 1". Journal of Hypertension. 24 (6): 1083-1088. doi:10.1097/01.hjh. ... 33 (1): 21-31. doi:10.1002/(sici)1098-2302(199807)33:1. 3.0.co;2-u. PMID 9664169. Heim, C; Newport, D J; Heit, S; Graham, Y P; ... 5 (1): 7-19. doi:10.1080/10615809208250484. Prigerson, H. G.; Shear, M. K.; Bierhals, A. J.; Zonarich, D. L.; Reynolds, C. F. ( ... 49 (1): 15-24. CiteSeerX 10.1.1.336.6204. doi:10.1037/0003-066x.49.1.15. PMID 8122813. Kaplan, G A; Keil, J E (October 1993). " ...
"E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro". Immunology. 77 (4 ... or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial ... Andrade CM, Sá MF, Toloi MR (April 2012). "Effects of phytoestrogens derived from soy bean on expression of adhesion molecules ... E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), ...
"Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry". J Virol. ... As well as oncolysis through the preferential targeting of cells that over-express the molecules ICAM-1 and/or DAF compared to ... 10 (1 Pt 1): 53-60. doi:10.1158/1078-0432.ccr-0690-3. PMID 14734451. Au GG; Lindberg AM; Barry RD; Shafren DR. (1 June 2005). " ... The virus is known to utilise the viral entry receptor ICAM-1 as its primary entry receptor, with DAF as a co-receptor to ...
... upregulates pancreatic acinar cell intercellular adhesion molecule-1 (ICAM-1) proteins through intracellular ... which mediates neutrophil adhesion to these cells". American Journal of Physiology. Gastrointestinal and Liver Physiology. 279 ... 33 (1): 48-58. doi:10.1111/j.1476-5381.1968.tb00473.x. PMC 1570274. PMID 5660165. Zaninovic V, Gukovskaya AS, Gukovsky I, ... Surface ICAM-1 in turn promotes neutrophil adhesion onto acinar cells enhancing pancreatic inflammation. In addition to ...
The now negatively charged Glu131 is primed to activate a water molecule for the hydrolysis of the intermolecular ring ... 163 (1): 348-56. doi:10.1016/s0022-5347(05)68050-0. PMID 10604388. Tan JX, Wang XY, Li HY, Su XL, Wang L, Ran L, Zheng K, Ren ... Hyaluronidase-1 is an enzyme that in humans is encoded by the HYAL1 gene. This gene encodes a lysosomal hyaluronidase. ... 48 (1): 63-70. doi:10.1006/geno.1997.5158. PMID 9503017. Triggs-Raine B, Salo TJ, Zhang H, Wicklow BA, Natowicz MR (May 1999 ...
"Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting ... "Entrez Gene: ICAM3 intercellular adhesion molecule 3". Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (Aug 1998 ... Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is ... The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I ...
... role of intercellular adhesion molecule-1 and nuclear factor-kappaB". Journal of Pharmacological Sciences. 108 (2): 198-205. ... Barbič, Matej; Schmidt, Thomas J.; Jürgenliemk, Guido (June 2012). "Novel Phenyl-1-benzoxepinols from Butcher's Broom (Rusci ... "Synthesis of Phenyl-1-benzoxepinols Isolated from Butcher's Broom and Analogous Benzoxepines". European Journal of Organic ...
... from binding to intercellular adhesion molecule 1 (ICAM-1). This mechanism down-regulates inflammation mediated by T ... May 2011). "The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the ... Lifitegrast inhibits an integrin, lymphocyte function-associated antigen 1 (LFA-1), ...
... and Maslinic Acid Interfere with Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1". ...
Berman PW, Nakamura GR (1994). "Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies ... intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. CD11a is one of the ... Turner ML, McIlwaine K, Anthony RS, Parker AC (1995). "Differential expression of cell adhesion molecules by human ... "Distribution of cell adhesion molecules on CD56++, CD3-, CD16- large granular lymphocytes and endothelial cells in first- ...
"Entrez Gene: intercellular adhesion molecule 1". Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG (Apr 1998). "The ... Intercellular+Adhesion+Molecule-1 at the US National Library of Medicine Medical Subject Headings (MeSH). ... Rothlein R, Dustin ML, Marlin SD, Springer TA (August 1986). "A human intercellular adhesion molecule (ICAM-1) distinct from ... Xiao X, Mruk DD, Cheng CY (2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 ...
March 2010). "Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in ... MSC expresses the adhesion molecules VCAM-1 and ICAM-1, which allow T-lymphocytes to adhere to their surface. Then MSC can ... Recent work suggests that β-catenin, via regulation of EZH2, is a central molecule in maintaining the "stemness" of MSC's. The ... MSCs produce many immunomodulatory molecules including prostaglandin E2 (PGE2), nitric oxide, indoleamine 2,3-dioxygenase (IDO ...
It binds to iC3b and can be involved in cellular adhesion, binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 ... For instance, while both CR3 and CR4 are involved in adhesion, migration and proliferation of B cells, they are involved in ... CR3 is a pattern recognition receptor, capable of recognizing and binding to many molecules found on the surfaces of invading ... A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules. Absence of CR3 results in reduced ...
"Outer membrane protein A of Escherichia coli K1 selectively enhances the expression of intercellular adhesion molecule-1 in ... OmpA from Escherichia coli is required for pathogenesis, and can interact with host receptor molecules. MotB (and MotA) serve ...
"Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant ... The AP-1 complex binds to a palindromic DNA motif (5'-TGA G/C TCA-3') to regulate gene expression, but specificity is dependent ... The AP-1 transcription factor has been shown to play numerous roles in cell growth and proliferation. In particular, c-Fos and ... AP-1 functions are heavily dependent on the specific Fos and Jun subunits contributing to AP-1 dimers. The outcome of AP-1 ...
... synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion ... PARP-1 and PARP-2 are activated by DNA single-strand breaks, and both PARP-1 and PARP-2 knockout mice have severe deficiencies ... 83 (1): 85-94. doi:10.1161/01.res.83.1.85. PMID 9670921. Zerfaoui M, Suzuki Y, Naura AS, Hans CP, Nichols C, Boulares AH ( ... 477 (1-2): 97-110. doi:10.1016/s0027-5107(01)00111-7. PMID 11376691. Isabelle M, Moreel X, Gagné JP, Rouleau M, Ethier C, Gagné ...
"Entrez Gene: ICAM2 intercellular adhesion molecule 2". Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August ... Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the ... The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I ... Bujía J, Holly A, Kim C, Scanady N, Kastenbauer E (1994). "Expression of human intercellular adhesion molecules in middle ear ...
"Epidermal growth factor-like domain 7 suppresses intercellular adhesion molecule 1 expression in response to hypoxia/ ... Egfl7 promotes tumour escape from immunity by repressing leukocyte adhesion molecules of tumor blood vessel endothelial cells. ... It interacts with and inhibits the catalytic activity of LOX, preventing the crosslink of tropoelastin molecules into mature ... and enhances the adhesion of Jurkat cells on these cells. GRCh38: Ensembl release 89: ENSG00000172889 - Ensembl, May 2017 ...
This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 ... 2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly ... liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that ... 8 (1): 27-37. doi:10.1089/aid.1992.8.27. PMID 1736938. Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC- ...
Recruitment is facilitated by the molecules P-selectin and E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular ... cell adhesion molecule 1 (VCAM-1). Monocytes are then able to penetrate the arterial wall as a result of impaired endothelial ... In addition, fluorescent microscopy or flow cytometry can be used to detect OxLDL uptake when OxLDL has been labeled with 1,1′- ... ISBN 978-1-4160-3121-5. Döring Y, Zernecke A (2012). "Plasmacytoid dendritic cells in atherosclerosis". Frontiers in Physiology ...
Intercellular adhesion molecule 1 (ICAM-1) has a central role in airway inflammation in asthma, and it is the receptor for 90% ... Inter-Cellular Adhesion Molecule 1), also known as CD54 (Cluster of Differentiation 54), on respiratory epithelial cells, as ... These molecules target human N-myristoyltransferase, an enzyme in the host cell which picornavirus requires in order to ... 26 (1): 135-62. doi:10.1128/CMR.00077-12. PMC 3553670. PMID 23297263. Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, ...
... and blocks binding to intercellular adhesion molecule-1". J. Immunol. 167 (6): 3099-106. doi:10.4049/jimmunol.167.6.3099. PMID ... Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene. This gene encodes a secreted ... 2006). "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)". Biochem. Biophys. Res. Commun. 346 (2): ... "Entrez Gene: ESM1 endothelial cell-specific molecule 1". Bechard D, Meignin V, Scherpereel A, et al. (2000). "Characterization ...
... an Antisense Inhibitor of Intercellular Adhesion Molecule 1, for the Treatment of Subjects with Active Crohn's Disease". ... which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation. Hitherto, ... ICAM-1 promotes the extravasation and activation of leukocytes (white blood cells), which is part of the inflammation process. ... 51 (1): 30-36. doi:10.1136/gut.51.1.30. PMC 1773277. PMID 12077088. Yacyshyn, Bruce; Chey, William Y.; Wedel, Mark K.; Yu, ...
... and intercellular adhesion molecule-1 are upregulated in ILVEN, similar to psoriasis. -The plaques are characterized ... 191 (1): 1-5. doi:10.1159/000246468. PMID 8589475. Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard ... Altman and Mehregan described six characteristic features of ILVEN: (1) early age of onset, (2) predominance in females (4:1 ... ILVEN occurs predominantly in females (female-male ratio, 4:1) with no racial predominance. Linear verrucous epidermal nevus ...
It is shown to be able to significantly decrease intercellular adhesion molecule-1 mRNA and protein levels and therefore reduce ... 4 (1): 22. doi:10.1186/s12348-014-0022-z. ISSN 1869-5760. PMC 4306439. PMID 25667683. Cornut, P.-L.; Chiquet, C. (October 2008 ... 44 (1): 56-62. doi:10.1016/j.jcrs.2017.10.040. ISSN 0886-3350. PMID 29502618. Pennsylvania, Maryann Scholl, PharmD Assistant ... The anesthetic takes time to show the numbing effect, ranging from 1-5 minutes, depending on the chemical chosen. The ...
Waxy micro- and nanostructures on the surface reduce wetting by rain and adhesion of contamination (See Lotus effect). ... The cells of the spongy layer are more branched and not so tightly packed, so that there are large intercellular air spaces ... The sugars are then stored as starch, further processed by chemical synthesis into more complex organic molecules such as ... The pores or stomata of the epidermis open into substomatal chambers, which are connected to the intercellular air spaces ...
... which reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes ... immune defense molecules indicative of Ebola infection were found in three bat species; at various periods of study, between ... 55: 1-9. doi:10.1016/j.jaut.2014.09.001. PMID 25260583.. *^ a b Smith, Tara (2005). Ebola (Deadly Diseases and Epidemics). ... 10 (1): 40-47. doi:10.3201/eid1001.030125. PMC 3322747. PMID 15078595.. *^ a b "Ebola haemorrhagic fever in Sudan, 1976" (PDF) ...
July 1998). "Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular ... The intercellular cleft itself is a channel, but what flows through the channel, like ions, fluid, and small molecules and what ... An intercellular cleft is a channel between two cells through which molecules may travel and gap junctions and tight junctions ... Research at the cell level can deliver proteins, ions, or specific small molecules into the intercellular cleft as a means of ...
Upregulation of intercellular adhesion molecule-1 (ICAM-1) and cytokines associated with T-helper 1 immune response, may also ... 978-1-60327-519-4. .. *^ a b c d Wagner G, Rose C, Sachse MM (April 2013). "Clinical variants of lichen planus". Journal der ... 978-1-4377-0314-6. .. *^ a b Freedberg IM, ed. (2003). Fitzpatrick's dermatology in general medicine (6th ed.). New York, NY: ... 978-1-4377-0314-6. .. *^ a b Gordon KA, Vega JM, Tosti A (Nov-Dec 2011). "Trachyonychia: a comprehensive review". Indian ...
Included in the glycocalyx are cell-adhesion molecules that enable cells to adhere to each other and guide the movement of ... and intercellular adhesion.[1] The glycocalyx is a type of identifier that the body uses to distinguish between its own healthy ... Generally, the carbohydrate portion of the glycolipids found on the surface of plasma membranes helps these molecules ... In arterial vascular tissue, the glycocalyx also inhibits coagulation and leukocyte adhesion, but through mediation of shear ...
1997). «Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin- ... implications for intercellular signaling.». Trends Biochem. Sci. 23 (4): 121-4. PMID 9584610. doi:10.1016/S0968-0004(98)01195-5 ... Reid RA, Bronson DD, Young KM, Hemperly JJ (1994). «Identification and characterization of the human cell adhesion molecule ... 2002). «Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members ...
homophilic cell adhesion via plasma membrane adhesion molecules. • entry of bacterium into host cell. • protein localization to ... a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Research. 54 (23): 6282-7. PMID 7954478.. ... cell adhesion molecule binding. • cadherin binding. • identical protein binding. Cellular component. • cell-cell adherens ... "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Experimental Cell Research. 294 (2): 345-55. ...
... and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines". Infection and ... "Pertussis Toxin B-Pentamer Mediates Intercellular Transfer of Membrane Proteins and Lipids". PLoS ONE. 8 (9): e72885. doi: ... experimental methods such as the use of Bessel beam plane illumination microscopy and FRET-based sensor molecules can better ... Liang, XP; Lamm, ME; Nedrud, JG (Sep 1, 1988). "Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and ...
Reid RA, Bronson DD, Young KM, Hemperly JJ (Jan 1994). "Identification and characterization of the human cell adhesion molecule ... implications for intercellular signaling". Trends in Biochemical Sciences. 23 (4): 121-4. doi:10.1016/S0968-0004(98)01195-5. ... four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily". Journal of Neurobiology ... "Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R". ...
... and intercellular adhesion molecule-1 (ICAM-1). CD44 and ICAM-1 were already known as cell adhesion molecules with other ... Because the molecule typically exists in vivo in its polyanionic form, it is most commonly referred to as hyaluronan. ... The introduction of protein-based cross-links,[66] the introduction of free-radical scavenging molecules such as sorbitol,[67] ... This added feature allows a researcher to form a desired shape, as well as to deliver therapeutic molecules, into a host.[80] ...
... as well as expression of leukocyte adhesion molecules such as E-selectin, intercellular adhesion molecule-1 (ICAM-1), and ... 2 (1): 64-70. doi:10.3201/eid0201.960111. PMC 2639801. PMID 8903201.. *^ a b c d e f g Taylor, L. (2007) Xenotransplantation. ... Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells.[1][29] ... vascular cell adhesion molecule-1 (VCAM-1).[21] This response is further perpetuated as normally binding between regulatory ...
Citron-K or its fly orthologue Sticky has been suggested to interact with several molecules in cytokinesis such as Kinesin-3 ( ... The dominant mode of failure was the inability of daughter cells, which are connected with a shorter intercellular bridge, to ... Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein ... To sum the process, Citron-K is important to keep proper structure of the midbody which holds the intercellular bridge ...
Later, the Secretin family evolved from the Adhesion GPCR receptor family before the split of nematodes.[16] Insect GPCRs ... Arrestin linking: The phosphorylated receptor can be linked to arrestin molecules that prevent it from binding (and activating ... Regulation of immune system activity and inflammation: chemokine receptors bind ligands that mediate intercellular ... More recently, an alternative classification system called GRAFS (Glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin) ...
... which reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes ... recognize infectious molecules associated with the virus.[45] On TLR activation, proteins including interferon regulatory ... 55: 1-9. doi:10.1016/j.jaut.2014.09.001. PMID 25260583.. *^ a b Smith, Tara (2005). Ebola (Deadly Diseases and Epidemics). ... 10 (1): 40-47. doi:10.3201/eid1001.030125. PMC 3322747. PMID 15078595.. *^ a b "Ebola haemorrhagic fever in Sudan, 1976" (PDF) ...
Soluble guanylate cyclase contains a molecule of heme, and is activated primarily by the binding of nitric oxide (NO) to that ... cGMP is an important second messenger that internalizes the message carried by intercellular messengers such as peptide ... RETGC-1 has been found to be expressed in higher levels in cones compared to rod cells. Studies have also shown that mutations ... Because RETGC-1 produces cGMP, which keeps cyclic nucleotide-gated channels open allowing the influx of calcium, this mutation ...
"Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345-55. PMID 15023525 ... a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Res. 54 (23): 6282-7. PMID 7954478.. ... Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL (December 1997). "Vinculin is associated with the E-cadherin adhesion complex". J. ... Wijnhoven BP, Dinjens WN, Pignatelli M (2000). "E-cadherin-catenin cell-cell adhesion complex and human cancer.". The British ...
They are short-lived and highly motile, or mobile, as they can enter parts of tissue where other cells/molecules cannot. ... and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into ... in order to dissolve intercellular connections (to the improvement of its mobility) and envelop bacteria through phagocytosis. ... Cell surface receptors allow neutrophils to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon ...
... bound to each other by cell adhesion molecules, with little intercellular space. Epithelial cells can be squamous (flat), ... nucleic acids and other biological molecules gave rise to a new field of molecular anatomy.[89] ... 978-1-4051-1113-3. .. *^ Ruppert, Edward E.; Fox, Richard, S.; Barnes, Robert D. (2004). Invertebrate Zoology, 7th edition. ... 52 (1): 45-49. doi:10.1258/rsmsmj.52.1.45. PMID 17373426.. *^ Waterston SW, Hutchison JD (2004). "Sir John Struthers MD FRCS ...
This specificity seems to be mediated by soluble signal molecules such as chemokines[12] and transforming growth factor beta.[ ... Recently, a series of high-profile experiments suggests that the co-option of intercellular cross-talk mediated by exosome ... the regulation of various types of cell-cell and cell-matrix adhesions is crucial during metastasis. ... 33 (1): 49-54. doi:10.1038/ng1060. PMID 12469122.. *^ van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. ( ...
... involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular ... 833 (1 Cancer): 204-7. Bibcode:1997NYASA.833..204N. doi:10.1111/j.1749-6632.1997.tb48611.x. PMID 9616756.. ... 124 (1): 157-162. doi:10.1093/oxfordjournals.jbchem.a022074. ISSN 0021-924X. PMID 9644258.. ...
... such as intercellular cell adhesion molecules (ICAMs) or vascular cell adhesion molecules (VCAMs) undergo heterophilic binding ... which uses one adhesion molecule called the circumsporozoite protein to bind to liver cells,[28] and another adhesion molecule ... Apart from altering the production of adhesion molecules, competitive inhibitors that bind to adhesion molecules to prevent ... Anti-adhesion therapy can be used to prevent infection by targeting adhesion molecules either on the pathogen or on the host ...
"JNK is a novel regulator of intercellular adhesion". Tissue Barriers. 1 (5): e26845. doi:10.4161/tisb.26845. PMC 3942331. PMID ... adhesion factors, and other molecules that can change cell fate.[79] This reprogramming of cellular phenotypes normally allows ... 1 (1): 1-15.. *^ a b Nowell PC (October 1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23-8. ... depending on the receptors that the cell expresses and the signaling molecules present inside the cell.[66][67] Collectively, ...
Ensures that molecules and current passing through the gap junction do not leak into the intercellular space. ... "Developmental exposure to estrogens alters epithelial cell adhesion and gap junction proteins in the adult rat prostate". ... Gap junctions are a specialized intercellular connection between a multitude of animal cell-types.[1][2][3] They directly ... One gap junction channel is composed of two connexons (or hemichannels), which connect across the intercellular space.[4][5][6] ...
This cell-to-ECM adhesion is regulated by specific cell-surface cellular adhesion molecules (CAM) known as integrins. Integrins ... in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression ... Cell adhesion[edit]. Many cells bind to components of the extracellular matrix. Cell adhesion can occur in two ways; by focal ... Plopper G (2007). The extracellular matrix and cell adhesion, in Cells (eds Lewin B, Cassimeris L, Lingappa V, Plopper G). ...
... is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node ... intercellular bridge. • perinuclear region of cytoplasm. • lysosome. • external side of plasma membrane. • cell periphery. ... cell adhesion. • endothelial cell proliferation. • mesangial cell-matrix adhesion. • tissue homeostasis. • positive regulation ... and Tindle et al.[8][9][10][11] in a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also ...
Highest negative charge density of any known biological molecule Heparan sulfate. GlcUA or IdoUA or IdoUA(2S). GlcNAc or GlcNS ... Keratan sulfate GAGs are found in many other tissues besides the cornea, where they are known to regulate macrophage adhesion, ... Hyaluronan networks retard diffusion and form a diffusion barrier that regulates transport of substances through intercellular ... or other matrix molecules. For example, with regards to stem cells, hyaluronan, along with chondroitin sulfate, helps to form ...
Ensures that molecules and current passing through the gap junction do not leak into the intercellular space. ... "Developmental exposure to estrogens alters epithelial cell adhesion and gap junction proteins in the adult rat prostate" ... Gap junctions are a specialized intercellular connection between a multitude of animal cell-types.[1][2][3] They directly ... The hemichannel pair connect across the intercellular space bridging the gap between two cells.[4][5][6] Gap junctions are ...
... inhibition of T cell activation and suppression of intercellular adhesion molecule expression by T cells; selective down- ... 47 (1): 25-50. doi:10.2165/00003495-199447010-00003. PMID 7510620.. *^ Sneader, Walter (2005). Drug Discovery: A History. John ... 4 (4): 340-1. PMID 10476546.. *^ Wessels, JA; Huizinga, TW; Guchelaar, HJ (March 2008). "Recent insights in the pharmacological ... Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.[1] It is used to ...
The release of the ADP molecule leads to the so-called rigor state of myosin.[6] The binding of a new ATP molecule will release ... which may be involved in maintaining stromal cell scaffolding required for maintaining intercellular contact. ... "Non-muscle myosin II takes centre stage in cell adhesion and migration". Nature Reviews. Molecular Cell Biology. 10 (11): 778- ... Multiple myosin II molecules generate force in skeletal muscle through a power stroke mechanism fuelled by the energy released ...
However, it has been shown that CTC clusters can "unwind" through "selective cleavage of intercellular adhesions" to traverse ... ViewRNA assay for CTCs characterization is the only in situ hybridization technology that allows multiplex, single-molecule RNA ... 1 (6): 740-751. PMC 3195935. PMID 22016824.. *^ a b Miller MC, Doyle GV, Terstappen LW (2010). "Significance of Circulating ... 2011: 1-10. doi:10.1155/2011/252361. PMC 3090615. PMID 21577258.. *^ da Costa A, Oliveira JT, Gärtner F, Kohn B, Gruber AD, ...
Definition of intercellular adhesion molecule-1. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms ... intercellular adhesion molecule-1. Definition: a glycoprotein that is expressed on a variety of cells. The natural ligand for ... ICAM-1 is LFA-1, but it also serves as the cellular receptor for rhinoviruses in respiratory epithelium. ...
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.. Ramer R1, Bublitz K, ... This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell ... Up-regulation of ICAM-1 mRNA by CBD in A549 was 4-fold at 3 μM, with significant effects already evident at 0.01 μM. ICAM-1 ... ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. In athymic ...
This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell ... Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). ... Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 FASEB J. 2012 Apr;26(4): ... This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell ...
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- ... Intercellular adhesion molecule 1Add BLAST. 510. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... "N-glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and ... "N-glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and ...
... p3.58 Intercellular adhesion molecule 1 (ICAM-1; CD54) is a cell adhesion molecule of immunoglobulin (Ig) superfamily... ... BB2; CD54; Cluster of differentiation 54; ICAM; ICAM-1; Ly47; MALA-2; ... A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol. 1986;137(4):1270-4.PubMedGoogle Scholar ... Intercellular adhesion molecule-1 as a drug target against asthma and rhinitis. Respirology. 2014; 19:508-513.PubMed ...
We hypothesized that the expression of intercellular adhesion molecule-1 even in vessels with high flow rates can be imaged at ... Rhodamine-loaded intercellular adhesion molecule-1-targeted microbubbles for dual-modality imaging under controlled shear ... Ex vivo results were translatable in vivo, confirming that intercellular adhesion molecule-1-targeted and rhodamine-loaded ... Using 2-photon laser scanning microscopy and contrast-enhanced ultrasound, intercellular adhesion molecule-1-targeted and ...
Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. Several cells, such as ... Kang X, Wang F, Xie JD, Cao J, Xian PZ (2005) Clinical evaluation of serum concentrations of intercellular adhesion molecule-1 ... Yamada M, Yanaba K, Takehara K, Sato S (2005) Clinical significance of serum levels of soluble intercellular adhesion molecule- ... Gho YS, Kleinman HK, Sosne G (1999) Angiogenic activity of human soluble intercellular adhesion molecule-1. Cancer Res 59(20): ...
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intercellular adhesion molecule;. LFA,. lymphocyte function-associated antigen;. VCAM,. vascular cell adhesion molecule;. IgSF, ... Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion ... Intercellular adhesion molecule-2 (ICAM-2) is a cell surface glycoprotein that is a ligand for the integrin lymphocyte function ... Intercellular adhesion molecule-4 binds {alpha}4{beta}1 and {alpha}V-family integrins through novel integrin-binding mechanisms ...
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.. H Xu, J A Gonzalo, Y St ... Intercellular adhesion molecule 1 (ICAM-1) is one of three immunoglobulin superfamily members that bind to the integrins ... Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. ... ICAM-1-deficient mice sensitized with D-Gal, however, are not protected from lethality when challenged with low doses of ...
Intercellular Adhesion Molecule-1 information including symptoms, causes, diseases, symptoms, treatments, and other medical and ... Intercellular *Adhesion *Molecule Interesting Medical Articles:. *Symptoms of the Silent Killer Diseases *Online Diagnosis * ... Description of Intercellular Adhesion Molecule-1. Intercellular Adhesion Molecule-1: A cell-surface ligand involved in ... Intercellular Adhesion Molecule-1: Related Topics. These medical condition or symptom topics may be relevant to medical ...
Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1.. N W Lukacs, S W Chensue ... Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. ... Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. ... Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. ...
The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an ... STRUCTURE OF THE TWO AMINO-TERMINAL DOMAINS OF HUMAN INTERCELLULAR ADHESION MOLECULE-1, ICAM-1. ...
A Study of a Human Anti-Intercellular Adhesion Molecule-1 Monoclonal Antibody, in Patients With Multiple Myeloma. The safety ...
A Study of a Human Anti-Intercellular Adhesion Molecule-1 Monoclonal Antibody, in Patients With Multiple Myeloma. The safety ... A Study of a Human Anti-Intercellular Adhesion Molecule-1 Monoclonal Antibody, in Patients With Multiple Myeloma. ... a Human Anti-Intercellular Adhesion Molecule 1 Monoclonal Antibody, in Patients With Relapsed/Refractory Multiple Myeloma. ... Phase 1. Study Design ICMJE Intervention Model: Single Group Assignment. Masking: None (Open Label). Primary Purpose: Treatment ...
The association between polymorphisms of the gene encoding intercellular adhesion molecule 1 (ICAM1) and gene-environment ... Li, X.X.; Liu, J.P.; Cheng, J.Q.; Han, S.H.; Geng, Y.J.; Wei, S. Intercellular adhesion molecule-1 gene K469E polymorphism and ... Li, Y.F.; Tsao, Y.H.; Gauderman, W.J.; Conti, D.V.; Avol, E.; Dubeau, L. Intercellular adhesion molecule-1 and childhood asthma ... Interaction of Intercellular Adhesion Molecule 1 (ICAM1) Polymorphisms and Environmental Tobacco Smoke on Childhood Asthma ...
The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an ... INTERCELLULAR ADHESION MOLECULE-1 A 185 Homo sapiens Fragment: TWO N-TERMINAL, IMMUNOGLOBULIN DOMAINS Mutation: N103Q, N118Q, ... STRUCTURE OF THE TWO AMINO-TERMINAL DOMAINS OF HUMAN INTERCELLULAR ADHESION MOLECULE-1, ICAM-1. *DOI: 10.2210/pdb1iam/pdb ... Version 1_2: 2011-07-13. Type: Non-polymer description, Version format compliance ...
Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell ... We show here that the expression of the Intercellular Adhesion Molecule-1 (ICAM-1) by mature DCs is critical for long-lasting ... ICAM-1-deficient mature DCs, however, failed to induce fully effective priming, because CD8+ T cells produced reduced amounts ... We conclude that ICAM-1-dependent long-lasting interactions between mature DCs and naive CD8+ T cells determine the survival of ...
The endothelial cell molecule intercellular adhesion molecule (ICAM)-1 plays an important role in the initiation of the ... Endothelial intercellular adhesion molecule (ICAM)-1 plays an important role in the recruitment of immune cells during the ... van de Stolpe A, van der Saag PT: Intercellular adhesion molecule-1. J Mol Med74 :13 -33,1996. ... Kado S, Wakatsuki T, Yamamoto M, Nagato N: Expression of intercellular adhesion molecule-1 induced by high glucose in human ...
4 This endothelial inflammatory response includes the expression of cell adhesion molecules, such as intercellular adhesion ... We investigated the effect of Egfl7 on endothelial cell intercellular adhesion molecule 1 expression in response to H/R injury. ... Epidermal Growth Factor-Like Domain 7 Suppresses Intercellular Adhesion Molecule 1 Expression in Response to Hypoxia/ ... Epidermal Growth Factor-Like Domain 7 Suppresses Intercellular Adhesion Molecule 1 Expression in Response to Hypoxia/ ...
... intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with ... Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure ... Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure ... Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure ...
Pillars Article: A Human Intercellular Adhesion Molecule (ICAM-1) Distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. Robert ... Pillars Article: A Human Intercellular Adhesion Molecule (ICAM-1) Distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274 ... Pillars Article: A Human Intercellular Adhesion Molecule (ICAM-1) Distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274 ... Pillars Article: A Human Intercellular Adhesion Molecule (ICAM-1) Distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274 ...
Relationship between intercellular adhesion molecule-1 and HLA class II expression in acute cellular rejection of human kidney ... Acute DiseaseBiomarkersBiopsy, NeedleCell Adhesion MoleculesGraft RejectionHLA-D AntigensHumansIntercellular Adhesion Molecule- ... Adhesion molecules as markers of acute cellular rejection of renal allografts.. *Vascular expression of adhesion molecules in ... Relationship between intercellular adhesion molecule-1 and HLA class II expression in acute cellular rejection of human kidney ...
The serum concentrations of the adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell ... Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 ... This study evaluated serum concentrations of soluble cell adhesion molecules in patients with gastric cancer and in healthy ... There was a significant association between preoperative levels of all three adhesion molecules and disease stage, gastric wall ...
Overall, a significant association between ICAM-1 K469E polymorphism and CAD was observed in the dominant model (OR=1.80; 95% ... A meta-analysis was conducted to assess the association between ICAM-1 K469E polymorphism and CAD susceptibility. Material ... ICAM-1) K469E polymorphism has been implicated in susceptibility to coronary artery disease (CAD). Several studies investigated ... Results of this meta-analysis suggest that ICAM-1 K469E polymorphism confers a risk factor of CAD. ...
... Holmlund, A. ... intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. Endothelium-dependent ( ... Intercellular Adhesion Molecule-1/*blood, Male, Middle Aged, Tunica Intima/anatomy & histology/immunology, Vascular Cell ... Neither hsCRP, nor the adhesion molecules were significantly related to carotid artery IMT. CONCLUSION: ICAM-1 was related to ...
The potential role of intercellular adhesion molecule 1 (ICAM-1) in the biology of human melanoma cells has stimulated interest ... Susceptibility of Cultured Human Melanoma Cell Lines to Enhancement by Retinoic Acid of Intercellular Adhesion Molecule 1 ... Susceptibility of Cultured Human Melanoma Cell Lines to Enhancement by Retinoic Acid of Intercellular Adhesion Molecule 1 ... Susceptibility of Cultured Human Melanoma Cell Lines to Enhancement by Retinoic Acid of Intercellular Adhesion Molecule 1 ...
intercellular adhesion molecule-1. PS. phosphorothioate. ODN. oligodeoxynucleotide. CHS. contact hypersensitivity. DNFB. 2,4- ... Intercellular adhesion molecule 1 (ICAM-1) is constitutively expressed at low levels on many cells, including vascular ... 1990) Expression of intercellular adhesion molecule-1 in murine allergic contact dermatitis. Int Arch Allergy Appl Immunol 93: ... 1995) Treatment of inflammatory diseases with a monoclonal antibody to intercellular adhesion molecule 1. Ciba Found Symp 189: ...
Effects of a thrombomodulin-derived peptide on monocyte adhesion and intercellular adhesion molecule-1 expression in ... Therefore, the aim of this study was to explore the effect of GC31 on intercellular adhesion molecule-1 (ICAM-1) expression in ... Western blot analysis for intercellular adhesion molecule-1. Crude proteins were extracted from HUVECs treated with 1 μg/ml LPS ... Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994; 180:95-109. [ ...
Abstract-It has been reported that fibrinogen may act as a bridging ligand, binding to intercellular adhesion molecule-1 (ICAM- ... Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial ... Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial ... Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial ...
  • By contrast, major differences are seen with vascular cell adhesion molecule-1 (VCAM-1), which binds α 4 integrins that lack an I domain. (pnas.org)
  • The ICAMs are more distantly related to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which bind α 4 integrins. (pnas.org)
  • The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. (ahajournals.org)
  • Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer pat. (nih.gov)
  • The serum concentrations of the adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) were investigated by ELISA in 57 gastric cancer patients, both before and 7 days after surgery, and in 47 healthy control subjects. (nih.gov)
  • METHODS: In 59 apparently healthy individuals, we measured serum levels of highly sensitive C-reactive protein (hsCRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. (diva-portal.org)
  • CONCLUSION: ICAM-1 was related to endothelial vasodilatory function, but not to IMT, suggesting that endothelial inflammatory activation is related to an impaired vascular relaxation in apparently healthy individuals. (diva-portal.org)
  • Our results suggested that GC31 suppressed LPS-mediated ICAM-1 expression by inhibiting the activation of NF-κB and partially by attenuating the activity of ERK1/2 and p38 MAPK in vascular endothelium, which may contribute to ameliorating vascular inflammatory diseases, such as uveitis. (molvis.org)
  • The fibrinogen-derived peptide Bβ15-42 bound to HSVECs ( K d 0.18 μmol/L). Preincubation of HSVECs with Bβ15-42, a neutralizing antibody to urokinase plasminogen activator (uPA), or the F(ab) 1 fragment of a monoclonal antibody to vascular endothelial cadherin significantly attenuated the increase in ICAM-1 stimulated by fibrinogen. (ahajournals.org)
  • Moreover, incubation of HSVECs with either fibrin monomer (1 μmol/L) or monoclonal antibodies to vascular endothelial cadherin (25 μg/mL) increased ICAM-1 protein concentration 3- to 4-fold. (ahajournals.org)
  • These findings indicate that cleavage of fibrinopeptide B from fibrinogen by endothelial uPA permits the exposed Bβ15-42 sequence of fibrinogen to bind to vascular endothelial cadherin on HSVECs and to upregulate the expression of ICAM-1. (ahajournals.org)
  • The demonstration that fibrinogen acts as a bridging ligand for adhesion of THP-1 cells (a monocytic cell line) to cultured HUVECs 12 could signify a potential mechanism for the promotion of monocyte infiltration into the vascular wall. (ahajournals.org)
  • By using adenovirus-mediated gene transfer, we show that overexpression of AP-1 proteins directly causes coinduction of gene expression of an adhesion molecule, intercellular adhesion molecule-1 (ICAM-1), and a chemokine, monocyte chemoattractant protein-1 (MCP-1), in human vascular endothelial cells (ECs). (ahajournals.org)
  • Because the induced expression of ICAM-1 and MCP-1 in ECs has been implicated in endothelial activation and a number of important vascular disorders, it is suggested that AP-1 activation may play an important role in the pathogeneses of inflammation, angiogenesis, and atherogenesis. (ahajournals.org)
  • Usually associated with the induction of adhesion molecules and chemokines, EC activation is a major feature of the development of a number of vascular processes, including inflammation, angiogenesis, and atherogenesis. (ahajournals.org)
  • The purpose of this study was to investigate the expression of intercellular adhesion molecule-1 (ICAM-1) in umbilical vascular of pregnant women with gestational diabetes mellitus (GDM) and the clinical significance. (spandidos-publications.com)
  • iv) expression levels of ICAM-1 in umbilical vascular of the two groups of patients were compared. (spandidos-publications.com)
  • Expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) in rat brain tissue was evaluated by immunohistochemical methods and western blot assays. (termedia.pl)
  • Intercellular adhesion molecule-1 is partly responsible for the adherence of cells of the immune system to each other , as well as to the vascular endothelium . (ccsu.edu)
  • ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. (cloud-clone.com)
  • The present study aimed to evaluate the effect of aqueous extract of Piper sarmentosum (P.s) on inflammatory markers like vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and C-reactive protein (CRP). (biomedcentral.com)
  • Immunohistochemical staining of frozen tissue sections using the ICAM-1 antibody RR1/1 demonstrated significant levels of ICAM-1 expression on human glioblastoma cells and on intratumoural vascular endothelial cells. (uab.edu)
  • 1 Because ECs control many functions critical to cellular, organ, and patient survival, the vascular system has been dubbed the organ of the intensivist. (aappublications.org)
  • Leukocyte interactions with vascular endothelium during inflammation occur through discrete steps involving selectin-mediated leukocyte rolling and subsequent firm adhesion mediated by members of the integrin and Ig families of adhesion molecules. (duke.edu)
  • We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions. (hindawi.com)
  • It suggested that curcumin could ameliorate diabetic vascular inflammation by decreasing ROS overproduction, reducing leukocyte-endothelium interaction, and inhibiting ICAM-1 and NOX2 expression. (hindawi.com)
  • Plasma was incubated with human umbilical vein endothelial cell monolayers, and expression of E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 on the surface of human umbilical vein endothelial cell monolayers was measured by means of enzyme-linked immunosorbent assay. (bairdinstitute.org.au)
  • Soluble plasma intercellular and vascular cell adhesion molecule 1 (but not E-selectin) were increased after bypass. (bairdinstitute.org.au)
  • However, endothelial cell expression of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 (but not E-selectin) were significantly decreased by exposure to postbypass plasma. (bairdinstitute.org.au)
  • Additionally, postbypass plasma inhibited interleukin 1beta-stimulated endothelial cell expression of vascular cell and intercellular adhesion molecule 1. (bairdinstitute.org.au)
  • Upregulated vascular expression of adhesion molecules might not be essential for endothelial activation after bypass. (bairdinstitute.org.au)
  • Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) seem to be related to thrombosis in few previous studies. (ijconline.id)
  • Percutaneous transluminal mitral valvuloplasty reduces circulating vascular cell adhesion molecule-1 in rheumatic mitral stenosis. (ijconline.id)
  • Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with the severity of thrombosis. (ijconline.id)
  • Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats. (ijconline.id)
  • The concentrations of soluble vascular cell adhesion molecule-1 and lipids are independently associated with venous thromboembolism. (ijconline.id)
  • Haghir H, Hejazi S M, Minaee S. Changes of Serum Intercellular Adhesion Molecule - 1, Vascular Adhesion Molecule-1 and C - Reactive Protein in Middle-Aged Men with Heart Failure after Eight Weeks of Aerobic Exercise. (ac.ir)
  • The purpose of this research was evaluation of changes in intercellular adhesion molecule - 1, vascular adhesion molecule-1 and C - reactive protein in middle-aged men with heart failure after eight weeks of aerobic exercise. (ac.ir)
  • 13. Witkowska AM. Soluble ICAM-1: a marker of vascular inflammation and lifestyle. (ac.ir)
  • In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. (wikipedia.org)
  • These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to facilitate transmigration of leukocytes across vascular endothelia in processes such as extravasation and the inflammatory response. (wikipedia.org)
  • The association between polymorphisms of the gene encoding intercellular adhesion molecule 1 (ICAM1) and gene-environment interactions with childhood asthma has not been fully investigated. (mdpi.com)
  • Intercellular Adhesion Molecule 1 (ICAM1)- Cloud-Clone Corp. (cloud-clone.com)
  • ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. (genecards.org)
  • Should the Canine Intercellular Adhesion Molecule 1 (ICAM1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (bestpractice-life.pl)
  • Description: A sandwich quantitative ELISA assay kit for detection of Canine Intercellular Adhesion Molecule 1 (ICAM1) in samples from serum, plasma, tissue homogenates or other biological fluids. (bestpractice-life.pl)
  • Latest news and deals related to Intercellular Adhesion Molecule 1 (Major Group Rhinovirus Receptor or CD54 or ICAM1) targeted therapeutics are also mentioned. (bizpr.co.uk)
  • Intercellular Adhesion Molecule 1 (ICAM-1) is a protein encoded by the ICAM1 gene, which acts as a receptor for major receptor group rhinovirus A-B capsid proteins and Coxsackievirus A21 capsid proteins. (bizpr.co.uk)
  • Moreover, the report reviews key players involved in Intercellular Adhesion Molecule 1 (Major Group Rhinovirus Receptor or CD54 or ICAM1) targeted therapeutics and enlists all their major and minor project. (bizpr.co.uk)
  • ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. (wikipedia.org)
  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). (uniprot.org)
  • A cell-surface ligand involved in leukocyte adhesion and inflammation. (rightdiagnosis.com)
  • The relationship between leukocyte adhesion and endothelial metabolism remains to be investigated. (springer.com)
  • To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. (elsevier.com)
  • These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke. (elsevier.com)
  • The natural ligand for ICAM-1 is LFA-1, but it also serves as the cellular receptor for rhinoviruses in respiratory epithelium. (drugs.com)
  • This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. (nih.gov)
  • 0.001-3 μM) elicited concentration-dependent ICAM-1 up-regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen-activated protein kinase. (nih.gov)
  • Up-regulation of ICAM-1 mRNA by CBD in A549 was 4-fold at 3 μM, with significant effects already evident at 0.01 μM. (nih.gov)
  • ICAM-1 induction became significant after 2 h, whereas significant TIMP-1 mRNA increases were observed only after 48 h. (nih.gov)
  • Inhibition of ICAM-1 by antibody or siRNA approaches reversed the anti-invasive and TIMP-1-upregulating action of CBD and the likewise ICAM-1-inducing cannabinoids Δ(9)-tetrahydrocannabinol and R(+)-methanandamide when compared to isotype or nonsilencing siRNA controls. (nih.gov)
  • ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. (nih.gov)
  • In athymic nude mice, CBD elicited a 2.6- and 3.0-fold increase of ICAM-1 and TIMP-1 protein in A549 xenografts, as compared to vehicle-treated animals, and an antimetastatic effect that was fully reversed by a neutralizing antibody against ICAM-1 [% metastatic lung nodules vs. isotype control (100%): 47.7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. (nih.gov)
  • Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness. (nih.gov)
  • In 1986, Timothy Springer and his group first described the tissue distribution of ICAM-1 into both hematopoietic cells, (viz. (springer.com)
  • 1986 ). In later years, further studies demonstrated that purified ICAM-1 protein acts as a natural ligand for the cell surface lymphocyte function-associated antigen 1. (springer.com)
  • Cai Y, Liu T, Fang F, Shen S, Xiong C. Involvement of ICAM-1 in impaired spermatogenesis after busulfan treatment in mice. (springer.com)
  • ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). (springer.com)
  • Lawson C, Wolf S. ICAM-1 signaling in endothelial cells. (springer.com)
  • Lindsberg PJ, Carpén O, Paetau A, Karjalainen-Lindsberg ML, Kaste M. Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. (springer.com)
  • Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). (springer.com)
  • Induction of ICAM-1 by TNF-alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC. (springer.com)
  • A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. (springer.com)
  • A form of circulating ICAM-1 in human serum. (springer.com)
  • Simmons D, Makgoba MW, Seed B. ICAM an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. (springer.com)
  • Van Den Engel NK, Heidenthal E, Vinke A, Kolb H, Martin S. Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1. (springer.com)
  • Soluble ICAM-1 (sICAM-1) is elevated in different cancers. (springer.com)
  • Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. (springer.com)
  • The crystal structure of intercellular adhesion molecule-2 (ICAM-2) revealed significant differences in the presentation of the critical acidic residue important for integrin binding between I and non-I-domain integrin ligands. (pnas.org)
  • Based on this crystal structure, we mutagenized ICAM-2 to localize the binding site for the integrin lymphocyte function-associated antigen-1 (LFA-1). (pnas.org)
  • Previous mutagenesis of ICAM-1 and ICAM-3, interpreted in light of the recently determined ICAM-1 and ICAM-2 structures, suggests similar binding sites. (pnas.org)
  • The binding site on VCAM-1 includes the lower portion of domain 1 and the upper part of domain 2, whereas the LFA-1 binding site on ICAM is confined to the upper part of domain 1. (pnas.org)
  • Intercellular adhesion molecule-2 (ICAM-2) is a cell surface glycoprotein that is a ligand for the integrin lymphocyte function-associated antigen-1 (LFA-1) and is constitutively expressed on endothelium, platelets, lymphocytes, and monocytes ( 1 , 2 ). (pnas.org)
  • These are about 35% identical in sequence to the first two IgSF domains of ICAM-1, ICAM-3, ICAM-4, and ICAM-5, which also function as ligands for LFA-1 ( 1 , 2 ). (pnas.org)
  • Recently x-ray crystal structures for domains 1 and 2 of ICAM-2, ICAM-1, VCAM-1, and MAdCAM-1 have been solved ( 11 - 16 ). (pnas.org)
  • Although a conserved sequence bearing an integrin-binding L(I)-E(D)-T(S)-S(P)-L motif is present in all ( 17 ), it has markedly different architectures in ICAM-1 and ICAM-2 compared with VCAM-1 and MAdCAM-1. (pnas.org)
  • In ICAM-2 and ICAM-1, the homologous Glu residue is present at the end of β-strand C and lies on a flatter surface on an edge of domain 1. (pnas.org)
  • Intercellular adhesion molecule 1 (ICAM-1) is one of three immunoglobulin superfamily members that bind to the integrins lymphocyte function associated 1 (LFA-1) and Mac-1 on leukocytes. (rupress.org)
  • We have generated mice that are genetically and functionally deficient in ICAM-1. (rupress.org)
  • Production of inflammatory cytokines such as tumor necrosis factor alpha or interleukin 1 is normal in ICAM-1-deficient mice, and thus protection appears to be related to a diminution in critical leukocyte-endothelial interactions. (rupress.org)
  • After sensitization with D-galactosamine (D-Gal), ICAM-1-deficient mice are resistant to the lethal effect of low doses of exotoxin (Staphylococcus aureus enterotoxin B [SEB]), which has been shown to mediate its toxic effects via the activation of specific T cells. (rupress.org)
  • In this model, ICAM-1-mediated protection against SEB lethality correlates with a decrease in the systemic release of inflammatory cytokines, as well as with prevention of extensive hepatocyte necrosis and hemorrhage. (rupress.org)
  • ICAM-1-deficient mice sensitized with D-Gal, however, are not protected from lethality when challenged with low doses of endotoxin (LPS). (rupress.org)
  • These studies show that the different contribution of ICAM-1 in the activation of either T cells or macrophages is decisive for the fatal outcome of the shock in these two models. (rupress.org)
  • This work suggests that anti-ICAM-1 therapy may be beneficial in both gram-positive and -negative septic shock, either by reducing T cell activation or by diminishing neutrophil infiltration. (rupress.org)
  • In the present study, we have examined the mechanism of TNF activation during Schistosoma mansoni egg granuloma formation and its relationship to the expression of ICAM-1. (jimmunol.org)
  • We have also assessed the increased expression of ICAM-1, its contribution to granuloma development, and its relationship with TNF during lesion formation. (jimmunol.org)
  • Increased steady state ICAM-1 mRNA expression was observed in primary egg granulomas when compared with normal lung and foreign body (Sephadex bead) granulomas, which suggests a role for ICAM-1 in Ag-induced lesion formation. (jimmunol.org)
  • Subsequent studies have demonstrated that sTNFR:Fc treatment down-regulated granuloma formation and ICAM-1 expression, thus suggesting one mechanism of TNF involvement in granuloma formation was through the induction of ICAM-1. (jimmunol.org)
  • Anti-ICAM-1 decreased the soluble egg Ag-specific T cell proliferation in vitro. (jimmunol.org)
  • In addition, passive immunization of mice with anti-ICAM-1 mAb during primary granuloma formation resulted in an attenuation of lesion development as compared with lesion development in a control Ab-treated group. (jimmunol.org)
  • The proliferative response to soluble egg Ag was also significantly reduced in ex vivo experiments that used spleen cells from the anti-ICAM-1 treated mice. (jimmunol.org)
  • These data demonstrate that both TNF and ICAM-1 participate in lymphocyte activation and granuloma formation and suggest that one mechanism of TNF in granuloma development is through TNF-induced ICAM-1 expression. (jimmunol.org)
  • This is a first in human study which will assess the safety and tolerability of a monoclonal antibody against ICAM-1 in patients with Multiple Myeloma. (clinicaltrials.gov)
  • We show here that the expression of the Intercellular Adhesion Molecule-1 (ICAM-1) by mature DCs is critical for long-lasting contacts with CD8+ T cells but dispensable for short-lived antigen-specific interactions. (nih.gov)
  • ICAM-1-deficient mature DCs, however, failed to induce fully effective priming, because CD8+ T cells produced reduced amounts of interferon gamma and were clonally depleted after 2 weeks. (nih.gov)
  • We conclude that ICAM-1-dependent long-lasting interactions between mature DCs and naive CD8+ T cells determine the survival of activated CD8+ T cells and the establishment of effective memory. (nih.gov)
  • Endothelial intercellular adhesion molecule (ICAM)-1 plays an important role in the recruitment of immune cells during the development of atherosclerotic plaque and is a marker of inflammatory disease. (diabetesjournals.org)
  • We performed bivariate quantitative genetic analyses to estimate genetic and environmental correlations between circulating ICAM-1 concentration and 17 phenotypes associated with the metabolic syndrome. (diabetesjournals.org)
  • Circulating ICAM-1 concentration is heritable ( h 2 = 0.56). (diabetesjournals.org)
  • Significant genetic correlations were not found between ICAM-1 and fasting or 2-h serum glucose or systolic or diastolic blood pressure. (diabetesjournals.org)
  • Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se. (diabetesjournals.org)
  • The endothelial cell molecule intercellular adhesion molecule (ICAM)-1 plays an important role in the initiation of the inflammatory process ( 3 - 5 ). (diabetesjournals.org)
  • thus, ICAM-1 plays a key role in the recruitment of immune cells during the development of atherosclerotic plaque. (diabetesjournals.org)
  • Circulating soluble ICAM-1 is a biochemical marker associated with atherosclerotic progression and other inflammatory disease processes ( 5 ). (diabetesjournals.org)
  • Although its role in the atherosclerotic process is now recognized, much remains to be learned about the mechanisms that regulate ICAM-1 expression. (diabetesjournals.org)
  • 4 This endothelial inflammatory response includes the expression of cell adhesion molecules, such as intercellular adhesion molecule 1 (ICAM-1), that allow circulating neutrophils to adhere to sites of endothelial injury. (ahajournals.org)
  • We evaluated whether sFLT-1, ICAM-1, and VCAM-1 are predictive markers for blood pressure reduction after RSD. (ahajournals.org)
  • Venous serum samples for measurement of sFlt-1, ICAM-1, and VCAM-1 were collected before and 6 months after RSD. (ahajournals.org)
  • Responders showed significantly higher serum levels of sFLT-1, ICAM-1, and VCAM-1 at baseline compared with nonresponders. (ahajournals.org)
  • Preoperative serum concentrations of ICAM-1 and VCAM-1 in gastric cancer patients were significantly higher when compared with those of healthy controls, whereas there were no differences regarding serum E-selectin levels. (nih.gov)
  • Serum levels of E-selectin, ICAM-1, and VCAM-1 correlated significantly with each other. (nih.gov)
  • Elevated preoperative serum levels of E-selectin, ICAM-1, and VCAM-1 levels were found in 24.6%, 33.3%, and 28.1% of patients, respectively. (nih.gov)
  • These findings suggest that serum concentrations of E-selectin, ICAM-1, and VCAM-1 may reflect tumor progression and metastasis, and may be clinically useful. (nih.gov)
  • Intercellular adhesion molecule-1 ( ICAM-1 ) K469E polymorphism has been implicated in susceptibility to coronary artery disease (CAD). (medscimonit.com)
  • A meta-analysis was conducted to assess the association between ICAM-1 K469E polymorphism and CAD susceptibility. (medscimonit.com)
  • Results of this meta-analysis suggest that ICAM-1 K469E polymorphism confers a risk factor of CAD. (medscimonit.com)
  • The potential role of intercellular adhesion molecule 1 (ICAM-1) in the biology of human melanoma cells has stimulated interest in the characterization of its modulation. (aacrjournals.org)
  • The present study has shown that the differentiating agent retinoic acid (RA) up-regulates ICAM-1 expression by melanoma cells in a dose- and time-dependent fashion. (aacrjournals.org)
  • The enhancement of ICAM-1 cell surface expression is paralleled by an increase in ICAM-1 mRNA. (aacrjournals.org)
  • Therefore, ICAM-1 represents an additional gene which may be transcriptionally regulated by RA. (aacrjournals.org)
  • The five melanoma cell lines tested displayed a differential susceptibility to the modulation of ICAM-1 expression by RA, since the cell line MeWo did not change in its ICAM-1 expression following incubation with RA. (aacrjournals.org)
  • Nevertheless, RA-insensitive as well as RA-sensitive melanoma cell lines displayed a higher increase in ICAM-1 expression following incubation with RA and cytokines than following incubation with each of them. (aacrjournals.org)
  • Analysis of the distribution in the melanoma cell lines of retinoic acid receptors (RARs) showed a relationship between susceptibility to a RA-mediated increase of ICAM-1 expression and RARβ expression, suggesting that the latter receptor may play a role in the phenomenon. (aacrjournals.org)
  • RARα and RARγ were present in RA-sensitive and -insensitive melanoma cell lines, suggesting that they play a role in the enhancement by RA of cytokine-mediated up-regulation of ICAM-1 expression. (aacrjournals.org)
  • One of several known roles for ICAM-1 is to increase the association of leukocytes with the luminal surface of endothelial cells in the vicinity of an inflammatory stimulus. (aspetjournals.org)
  • Therefore, the aim of this study was to explore the effect of GC31 on intercellular adhesion molecule-1 (ICAM-1) expression in LPS-activated endothelial cells. (molvis.org)
  • ICAM-1 messenger RNA and protein levels were evaluated with real-time PCR and western blot. (molvis.org)
  • Upon LPS stimulation, GC31 suppressed the mRNA and protein expression of ICAM-1 in HUVECs and remarkably reduced monocyte-endothelial cell adhesion in a dose-dependent manner. (molvis.org)
  • A major consequence of the LPS action on endothelial cells is the upregulation of genes specifically involved in recruiting and adhering leukocytes [ 7 ].The firm adhesion of leukocytes to the vessel wall occurs via interaction of the CD11a/CD18 (β2) integrins to endothelial ligands such as intercellular adhesion molecule-1 (ICAM-1). (molvis.org)
  • Abstract -It has been reported that fibrinogen may act as a bridging ligand, binding to intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells and to Mac-1 on THP-1 cells (a monocytic cell line) to increase adhesion. (ahajournals.org)
  • In this study, we investigated whether fibrinogen altered the expression of ICAM-1 and, thus, increased the adhesion of THP-1 cells to cultured human saphenous vein endothelial cells (HSVECs). (ahajournals.org)
  • Incubation of HSVECs with 0.3 to 4 μmol/L fibrinogen caused a time- and concentration-dependent increase in ICAM-1, as determined by ELISA. (ahajournals.org)
  • The 4- to 5-fold increase in ICAM-1 protein concentration in HSVECs stimulated by 4 μmol/L fibrinogen for 6 hours was concomitant with a 4- to 5-fold increase in ICAM-1 mRNA. (ahajournals.org)
  • This fibrinogen-stimulated ICAM-1 upregulation was associated with a 2-fold increase in THP-1 cell adhesion to HSVECs. (ahajournals.org)
  • 8 9 The rapid and sustained increase in intercellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVECs) cultured in the presence of fibrin 10 could potentiate a number of cellular events mediated through this adhesion molecule. (ahajournals.org)
  • In keeping with this hypothesis, fibrinogen has been shown to mediate endothelium-dependent vasoactive effects on the saphenous vein that can be partially inhibited by a neutralizing antibody against ICAM-1. (ahajournals.org)
  • The role of fibrinogen as a bridging ligand was attributed to binding of the γ117-133 sequence of the fibrinogen D domain to ICAM-1 on endothelial cells. (ahajournals.org)
  • The chronological expression (over 24 h) of two adhesion molecules [intercellular adhesion molecule-1 (ICAM-1) and CD11b/CD18 (Mac-1)] and the extent of liver damage, including injury to sinusoidal endothelial cells (SECs) and hepatocyte apoptosis, were investigated under two conditions of rat liver ischemia-reperfusion (I/R) injury: reversible (30 min) and fatal I/R (60 min). (physiology.org)
  • The chronological profiles of upregulation of ICAM-1 on hepatocytes and Mac-1 showed changes in parallel with the other liver damage parameters, and the extent of upregulation and various parameters of liver injury were more advanced in the 60-min I/R group. (physiology.org)
  • Paradoxically, the degree of ICAM-1 upregulation of SECs decreased significantly in the 60-min I/R group vs. the 30-min I/R group. (physiology.org)
  • Although many adhesion molecules have been identified, various in vitro studies have shown that during hepatic I/R the β 2 integrin CD11b/CD18 (Mac-1) as well as their counterreceptor, intercellular adhesion molecule-1 (ICAM-1) ( 5 ), play a critical role in neutrophil transendothelial migration ( 9 , 28 ) and adherence to hepatocytes ( 24 ). (physiology.org)
  • In vivo studies ( 7 , 12 , 18 ) have revealed that Mac-1 and ICAM-1 monoclonal antibodies given intravenously before and/or during reperfusion reduce liver injury in I/R and in endotoxic shock models ( 6 , 17 ). (physiology.org)
  • Likewise, antibodies may not block all the adhesive interactions of the targeted molecule, especially in the case of ICAM-1, which has multiple integrin binding sites ( 32 ). (physiology.org)
  • Using an adenovirus-mediated gene transfer protocol, we found that the AP-1 proteins c-Fos and c-Jun directly cause phenotypic activation and induction of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human ECs. (ahajournals.org)
  • The coinduction of ICAM-1 and MCP-1 may represent coordinated events in endothelial activation processes, such as inflammation, angiogenesis, and atherogenesis. (ahajournals.org)
  • To elucidate the mechanisms of the transendothelial migration of leukocytes, we attempted to identify the cellular proteins capable of interaction with the cytoplasmic domain of the adhesion molecule intercellular adhesion molecule-1 (ICAM-1), in a rat brain microvessel endothelial cell line (RBE4 cells). (springer.com)
  • A 27-residues peptide, corresponding to the cytoplasmic domain of rat ICAM-1, was synthesized and coupled to CNBr-activated Sepharose 4B. (springer.com)
  • By affinity chromatography and elution with the soluble synthesized peptide, several ICAM-1 interacting proteins were purified from the RBE4 cell cytosol. (springer.com)
  • Experiments carried out with purified GAPDH showed that the enzyme directly interacts with the ICAM-1 matrix. (springer.com)
  • A series of synthetic ICAM-1 C-terminal peptides were tested for their ability to bind GAPDH and affect the glycolytic enzyme activity. (springer.com)
  • Our results suggest that GAPDH may interact with the C-terminal moiety of the ICAM-1 intracellular domain and that this interaction may affect the metabolic state of endothelial cells. (springer.com)
  • Dans le but de préciser les mécanismes impliqués dans la migration transendothéliale des leucocytes, nous avons cherché à identifier, dans la lignée RBE4 de cellules endothéliales cérébrales de rat, les protéines cellulaires capables d'interagir avec le domaine cytoplas-mique de la molécule d'adhérence ICAM-1. (springer.com)
  • Un peptide de 27 résidus, correspondant au domaine cytoplasmique de la molécule ICAM-1 de rat, a été synthétisé et couplé à un support de Sépharose 4B. (springer.com)
  • Cette matrice d'affinité a permis, à partir du cytosol de cellules RBE4, la purification de protéines capables de s'associer spécifiquement avec ICAM-1, l'élution se faisant grâce au peptide synthétisé soluble. (springer.com)
  • Des expériences effectuées avec la GAPDH purifiée montrent qu'elle interagit directement avec le support ICAM-1. (springer.com)
  • De plus, le NAD + permet l'élution de la GAPDH retenue sur le support ICAM-1. (springer.com)
  • iv) no significant differences in expression levels of ICAM-1 in umbilical artery and umbilical vein endothelial cells were found between the groups (p>0.05). (spandidos-publications.com)
  • The expression of ICAM-1 and VEGF in rat brain tissue was rare in the sham group, but was significantly elevated in the CIR group (p (termedia.pl)
  • Hence, the brain injury in ischemia-reperfusion rat models following CIH intervention may be related to the increased expression of ICAM-1 and VEGF. (termedia.pl)
  • Cell proteins were extracted and analyzed for intracellular adhesion molecule 1 (ICAM-1) levels and cell death ELISA. (arvojournals.org)
  • REC were also transfected with or without NF-κB siRNA before melphalan treatment to determine the involvement of NF-κB in REC apoptosis and ICAM-1 levels. (arvojournals.org)
  • Cell lysates were processed for ICAM-1 levels and cell death ELISA. (arvojournals.org)
  • Phospho-P38MAPK inhibitor was also treated before KZ-41 and melphalan treatment and cell lysates were tested for ICAM-1 levels and REC cell death. (arvojournals.org)
  • KZ-41 could inhibit melphalan-induced ICAM-1 levels and REC apoptosis. (arvojournals.org)
  • Use of KZ-41 to block NF-κB and activate P38MAPK protects REC against melphalan-induced upregulation of ICAM-1 and apoptosis. (arvojournals.org)
  • To study the potential roles of protein kinase C (PKC) on expression of intercellular adhesion molecule-1 (ICAM-1) in rat brain microvascular endothelial cells (RBMEC). (chinaphar.com)
  • ICAM-1 expression in RBMEC was measured by ELISA analyses. (chinaphar.com)
  • Phorbol ester (PMA) enhanced the expression of ICAM-1 in a concentration (10-100 nmol.L-1) and time (4-16 h)-dependent manner in RBMEC. (chinaphar.com)
  • Pentoxifylline (PTX) 1-100 mumol.L-1 and the PKC inhibitor H7 5-50 mumol.L-1 prevented PMA-induced stimulation of ICAM-1 expression. (chinaphar.com)
  • Activation of PKC in RBMEC is associated with increased expression of ICAM-1 in RBMEC. (chinaphar.com)
  • PTX and H7 preincubation may inhibit PKC-induced up-regulation of ICAM-1. (chinaphar.com)
  • Adhesion molecules such as ICAM-1 have been proposed to play important roles in the metastasis of malignant diseases. (nii.ac.jp)
  • In the present study, we measured serum soluble ICAM-1 (sICAM-1) levels by ELISA in 20 abdominal malignant tumor patients (10 without metastasis and 10 with metastasis) during anesthesia. (nii.ac.jp)
  • Bone homeostasis takes place through the interaction of bone cells (osteoblasts and osteoclast) via the activation of intercellular adhesion molecule-1 (ICAM-1), which is a critical submolecule of integrin. (eurekaselect.com)
  • In the present study, we reviewed several novel studies on integrins and their submolecule, ICAM-1, in bone homeostasis. (eurekaselect.com)
  • In order to demonstrated that ICAM-1 might exert dual effects on osteoclastogenesis by directly affecting the adhesive ability of mature osteoclasts and indirectly participating in RANKL/RANK induced osteoclastic precursors differentiation. (eurekaselect.com)
  • Although these results still need to be verified in the future, the extending study about the role of ICAM-1 in osteoclastogenesis will cerntainly provide a promising therapeutic target for the treatment of bone loss diseases. (eurekaselect.com)
  • Markedly diminished epidermal keratinocyte expression of intercellular adhesion molecule-1 (ICAM-1) in Sézary syndrome. (semanticscholar.org)
  • Increased expression of intercellular adhesion molecule-1 (ICAM-1) accompanies and is believed to be important in BBB disruption in other CNS injuries. (semanticscholar.org)
  • The effect of CsA on the cytokine-induced expression of ICAM-1 on A549 and IMR-90 cells was studied . (ccsu.edu)
  • The expression of ICAM-1 on these cells is significant between 4 and 8 hours after stimulation and peaks between 16 and 18 hours . (ccsu.edu)
  • Neither IL-1- nor IFN-T-induced ICAM-1 expression were significantly inhibited . (ccsu.edu)
  • Furthermore , in an 18 hour TNF-induced ICAM-1 expression assay , when CsA was added 4 hours after the initiation of the culture , no significant suppression of ICAM-1 was seen . (ccsu.edu)
  • Moreover , in the presence of TNF and CsA , the A549 cells could respond to another inducer (IL-1) of ICAM-1 expression , providing further evidence that the cells are not compromised by the combination of TNF and CsA . (ccsu.edu)
  • These results suggest that CsA selectively suppresses an early activation event in the path to ICAM-1 expression only when TNF is the inducing agent . (ccsu.edu)
  • Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. (rupress.org)
  • Intercellular adhesion molecule-1 (ICAM-1) on the surface of cultured umbilical vein and saphenous vein endothelial cells was upregulated between 2.5- and 40-fold by rIL-1, rTNF, LPS and rIFN gamma corresponding to up to 5 X 10(6) sites/cell. (rupress.org)
  • Endothelial cell ICAM-1 was a single band of 90 kD in SDS-PAGE. (rupress.org)
  • Purified endothelial cell ICAM-1 reconstituted into liposomes and bound to plastic was an excellent substrate for both JY B lymphoblastoid cell and T lymphoblast adhesion. (rupress.org)
  • Adhesion to endothelial cell ICAM-1 in planar membranes was blocked completely by monoclonal antibodies to lymphocyte function associated antigen-1 (LFA-1) or ICAM-1. (rupress.org)
  • Adhesion to artificial membranes was most sensitive to ICAM-1 density within the physiological range found on resting and stimulated endothelial cells. (rupress.org)
  • The LFA-1-dependent adhesion could be further subdivided into an LFA-1/ICAM-1-dependent component which was increased by cytokines and a basal LFA-1-dependent, ICAM-1-independent component which did not appear to be affected by cytokines. (rupress.org)
  • We conclude that ICAM-1 is a regulated ligand for lymphocyte-endothelial cell adhesion, but at least two other major adhesion pathways exist. (rupress.org)
  • ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. (cloud-clone.com)
  • ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. (cloud-clone.com)
  • When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). (cloud-clone.com)
  • Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. (cloud-clone.com)
  • Rabbits fed with 1% cholesterol diet (CH) showed significant increase in the level of VCAM-1, ICAM-1 and CRP compared to the C group. (biomedcentral.com)
  • The levels of VCAM-1, ICAM-1 and CRP in the 1% cholesterol group and supplemented with P.s (500 mg/kg) were significantly reduced compared to the cholesterol group. (biomedcentral.com)
  • Asn-Ala-ICAM 1 (1-21) inhibits virus replication in HIV-1 infected HTLV-1 transformed cells (MT-2 cells). (vwr.com)
  • We hypothesized that higher concentrations of intercellular adhesion molecule-1 (ICAM-1) and von Willebrand factor (vWF) would be associated with the occurrence of PGD. (elsevier.com)
  • Logistic regression and generalized estimating equations (GEE) were used to analyze plasma ICAM-1 and vWF. (elsevier.com)
  • At each postoperative timepoint, mean plasma ICAM-1 concentrations were higher for patients with PGD versus no PGD. (elsevier.com)
  • The GEE contrast estimate for the association of plasma ICAM-1 with PGD was 107.5 ng/mL (95% CI 38.7, 176.3), p = 0.002. (elsevier.com)
  • We conclude that higher levels of plasma ICAM-1 are associated with PGD following lung transplantation. (elsevier.com)
  • Since the initiation of a specific immune response also involves antigen-receptor independent interactions between accessory molecules, such as lymphocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-3 (LFA-3) with CD2, it was of interest to determine whether TEC can express the adhesion molecules (ICAM-1 and LFA-3) which augment the efficiency of antigen presentation. (ox.ac.uk)
  • Cultured TEC were studied for their expression of ICAM-1 and LFA-3 by immunofluorescence. (ox.ac.uk)
  • However, using the same stimuli, TEC from non-toxic goitre were induced to express ICAM-1, but not LFA-3. (ox.ac.uk)
  • To establish whether ICAM-1 and LFA-3 on TEC were expressed in vivo during the disease process, antibodies against these molecules were incubated with frozen sections of autoimmune thyroiditis, including Graves' and Hashimoto's diseases, and non-toxic goitre. (ox.ac.uk)
  • Both ICAM-1 and LFA-3 were highly expressed in the autoimmune diseases, but not in non-toxic goitre. (ox.ac.uk)
  • Expression of ICAM-1 is induced in close proximity to foci of bacterial infection in the liver, including on CD31(+) endothelial cells, and blockade of CD11b and CD44 diminishes monocyte localization to these hepatic foci. (ox.ac.uk)
  • To determine the possible contribution of adhesion receptors to these restrictions, we have studied binding between the murine and human homologues of LFA-1 (CD11a/CD18) and ICAM employing purified human LFA-1 and ICAM-1 (CD54) bound to solid substrates. (ox.ac.uk)
  • Murine cell lines bind to purified human LFA-1 through ICAM-1 and at least one other counter-receptor. (ox.ac.uk)
  • In contrast to binding of murine ICAM-1 to human LFA-1, murine LFA-1 does not bind to human ICAM-1. (ox.ac.uk)
  • The species specificity maps to the LFA-1 alpha subunit, because mouse x human hybrid cells expressing the human alpha subunit associated with a mouse beta subunit bind to human ICAM-1, whereas those with a human beta subunit associated with a murine alpha subunit do not. (ox.ac.uk)
  • Increased adhesiveness for ICAM-1 stimulated by phorbol esters could be demonstrated for hybrid LFA-1 molecules with human alpha and murine beta subunits. (ox.ac.uk)
  • A functional analysis of a natural variant of intercellular adhesion molecule-1 (ICAM-1Kilifi). (ox.ac.uk)
  • Intercellular adhesion molecule-1 (ICAM-1) is involved in a range of interactions both within the host and between the host and a number of pathogens. (ox.ac.uk)
  • Recently we described a mutation within the coding region of the first N-terminal immunoglobulin-like domain of ICAM-1, present at high frequency within African populations, which increased the risk of cerebral malaria. (ox.ac.uk)
  • To understand the mechanism by which such a polymorphism might be maintained despite counter-selection by malaria, we have carried out functional assays using both forms of ICAM-1 as soluble Fc chimeric fusion proteins. (ox.ac.uk)
  • ICAM-1Kilifi has reduced avidity for LFA-1 compared with ICAM-1ref and binding to soluble fibrinogen was completely abolished with the Kilifi variant. (ox.ac.uk)
  • In Plasmodium falciparum adhesion assays, ITO4-A4u binding to ICAM-1Kilifi was reduced compared with binding to the reference form. (ox.ac.uk)
  • These results allow for the possibility of balanced selection between the reference and Kilifi forms of ICAM-1 through modulation of inflammatory responses and indicate the existence of differences within ICAM-1-binding P. falciparum isolates which may be relevant to pathogenesis. (ox.ac.uk)
  • Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). (mblwhoilibrary.org)
  • Previous studies have demonstrated dimerization of intercellular adhesion molecule-1 (ICAM-1) on the cell surface and suggested a role for immunoglobulin superfamily domain 5 and/or the transmembrane domain in mediating such dimerization. (mblwhoilibrary.org)
  • ICAM-1 binds through domain 1 to the I domain of the integrin alpha(L)beta(2) (lymphocyte function-associated antigen 1). (mblwhoilibrary.org)
  • Soluble C-terminally dimerized ICAM-1 was made by replacing the transmembrane and cytoplasmic domains with an alpha-helical coiled coil. (mblwhoilibrary.org)
  • To capture ICAM-1 dimerized at the crystallographically defined dimer interface in domain 1, cysteines were introduced into this interface. (mblwhoilibrary.org)
  • Several of these mutations resulted in the formation of soluble disulfide-bonded ICAM-1 dimers (domain 1 dimers). (mblwhoilibrary.org)
  • Surface plasmon resonance studies showed that all of the dimeric forms of ICAM-1 (domain 1, C-terminal, and domain 1/C-terminal dimers) bound similarly to the integrin alpha(L)beta(2) I domain, with affinities approximately 1.5--3-fold greater than that of monomeric ICAM-1. (mblwhoilibrary.org)
  • These studies demonstrate that ICAM-1 can form at least three different topologies and that dimerization at domain 1 does not interfere with binding in domain 1 to alpha(L)beta(2). (mblwhoilibrary.org)
  • We have expressed in Escherichia coli the two N-terminal immunoglobulin (Ig)-like domains of the intercellular adhesion molecule 1 (ICAM-1). (mblwhoilibrary.org)
  • The first 188 residues of ICAM-1 were expressed with an N-terminal methionine (MP188) or as a maltose-binding fusion protein which was cleaved with factor Xa (XP188). (mblwhoilibrary.org)
  • After refolding, both MP188 and XP188 were active in binding to the leukocyte integrin lymphocyte function-associated antigen 1, which has previously been shown to bind to the N-terminal Ig domain of ICAM-1. (mblwhoilibrary.org)
  • The major group of rhinoviruses and malaria-infected erythrocytes bind to distinct sites within the first Ig-like domain of ICAM-1. (mblwhoilibrary.org)
  • These results show that functionally active fragments of ICAM-1 can be produced in E. coli, that glycosylation is not required for ligand binding, and that the N-terminal residue of ICAM-1 is proximal to or part of the human rhinovirus-binding site. (mblwhoilibrary.org)
  • Elevated serum levels of intercellular adhesion molecule ICAM-1 in Pseudoxanthoma elasticum. (cdc.gov)
  • Here, we investigated the cell adhesion molecules ICAM-1 in PXE patients. (cdc.gov)
  • Soluble ICAM-1 was determined in 58 non-consanguineous PXE patients by quantitative sandwich enzyme immunoassay. (cdc.gov)
  • The allelic frequencies of the ICAM-1 variant p.K469E were analyzed in patients and age- and sex-matched controls. (cdc.gov)
  • In addition, the ICAM-1 concentration correlated with the ABCC6 gene status of the PXE patients. (cdc.gov)
  • Our data show for the first time increased ICAM-1 concentrations in PXE patients, potentially due to the chronic oxidative stress and elevated protease activity followed by extracellular matrix remodeling which have been previously observed in PXE patients. (cdc.gov)
  • Intercellular adhesion molecule-1 (ICAM-1) has recently been identified as one of the ligands for lymphocyte function-associated antigen-1 (LFA-1). (uab.edu)
  • ICAM-1 was weakly expressed or absent from low grade gliomas and absent from normal and fetal brain. (uab.edu)
  • ICAM-1 expression was similar to that of MHC class II, HLA-DR antigens. (uab.edu)
  • Glioblastoma cell lines constitutively expressed ICAM-1 to a minimal or moderate extent. (uab.edu)
  • Surface antigen expression of ICAM-1 and ICAM-1-specific mRNA could be significantly increased by incubating glioblastoma cells with interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). (uab.edu)
  • Significant enhancement of ICAM-1 expression was obtained using TNF-α and IL-1β at 1-10 U/ml and at 500 U/ml of IFN-γ. (uab.edu)
  • Induction of ICAM-1 specific mRNA was observed 4 h after cytokine treatment and decreased by 24 h. (uab.edu)
  • Surface antigen expression of ICAM-1 increased for up to 48 h after treatment. (uab.edu)
  • We show that intercellular adhesion molecule-1 (ICAM-1) is differentially expressed in human TNBC tumor tissues by immunohistochemistry and in human TNBC cell lines via quantification of gene and protein expression. (pnas.org)
  • Iron oxide nanoparticles functionalized with ICAM-1 antibody (ICAM-IONP) were synthesized as MRI probes. (pnas.org)
  • An in vivo signal enhancement of 2.6-fold for ICAM-IONPs was measured relative to controls, demonstrating that ICAM-1 is a potential diagnostic and therapeutic target for TNBC treatment. (pnas.org)
  • Herein, we describe the overexpression of intercellular adhesion molecule-1 (ICAM-1) in human TNBC cell lines and tissues, and demonstrate that ICAM-1 is a potential molecular target and biomarker for TNBC therapy and diagnosis. (pnas.org)
  • We synthesized ICAM-1 antibody-conjugated iron oxide nanoparticles (ICAM-IONPs) as a magnetic resonance imaging (MRI) probe to evaluate tumor targeting. (pnas.org)
  • Quantitative analysis of ICAM-1 surface expression predicted the targeting capability of ICAM-IONPs to TNBC cells. (pnas.org)
  • MRI of the TNBC xenograft tumor after systemic administration of ICAM-IONPs, coupled with iron quantification and histology, demonstrated a significant and sustained MRI contrast enhancement and probe accumulation in tumors with ICAM-1 overexpression relative to control. (pnas.org)
  • Identification of ICAM-1 as a TNBC target and biomarker may lead to the development of a new strategy and platform for addressing a critical gap in TNBC patient care. (pnas.org)
  • Intercellular adhesion molecule-1 (ICAM-1, CD54) gene polymorphisms have been implicated in the susceptibility to a range of inflammatory diseases, including inflammatory bowel disease (IBD). (cdc.gov)
  • ICAM-1 is expressed on proliferating bile ducts and interlobular bile ducts in late stage PSC and serum levels of soluble intercellular adhesion molecules are increased in PSC. (cdc.gov)
  • The aim of this study was to analyse ICAM-1 gene polymorphisms in PSC patients. (cdc.gov)
  • PCR with sequence-specific primers (PCR-SSP) was used to detect both ICAM-1 biallelic polymorphisms G241R and K469E. (cdc.gov)
  • The E469E homozygote status for ICAM-1 is associated with protection against PSC. (cdc.gov)
  • We assessed interstitial and glomerular leukocytes using an avidin-biotin-peroxidase method with monoclonal antibodies (MAbs) against leukocytes (CD45), beta2-integrin (CD18), macrophages (CD14), T cells (CD3) and T-cell subsets (CD4, CD8), intercellular adhesion molecule-1 (ICAM-1) (CD54), and HLA class II antigens. (geoscience.net)
  • We analyzed their relation with the abnormal expression of ICAM-1 on proximal tubular epithelium in sequential renal sections from 57 patients with IgA nephropathy stratified by degrees of interstitial cellular infiltration as seen by light microscopy. (geoscience.net)
  • Epithelial tubular cells expressing ICAM-1 may be a marker of tubulointerstitial disturbance upregulated by interstitial and glomerular infiltration of macrophages and T cells in IgA nephropathy. (geoscience.net)
  • Intercellular adhesion molecule-1 (ICAM-1) mediates eosinophil adhesion to nerves. (elsevier.com)
  • Objective: We investigated mechanisms of ICAM-1 expression by parasympathetic nerves. (elsevier.com)
  • Methods: ICAM-1 expression was examined by immunocytochemistry of lung sections from ovalbumin-sensitized and challenged guinea pigs. (elsevier.com)
  • ICAM-1 was measured in parasympathetic nerves isolated from subjects and guinea pigs and in human neuroblastoma cells by real-time RT-PCR, immunocytochemistry, and Western blot. (elsevier.com)
  • Results: ICAM-1 was not detected in control airway parasympatheric nerves in vivo or in cultured cells. (elsevier.com)
  • ICAM-1 was expressed throughout antigen-challenged guinea pig lung tissue and was selectively decreased by dexamethasone only in nerves. (elsevier.com)
  • ICAM-1 was induced in human and guinea pig parasympathetic nerves by TNF-α and IFN-γ and was inhibited by dexamethasone and by an inhibitor of nuclear factor-κB (NF-κB). (elsevier.com)
  • In neuroblastoma cell lines TNF-α and IFN-γ-induced ICAM-1 was blocked by an inhibitor of NF-κB but not by inhibitors of mitogen-activated protein kinases. (elsevier.com)
  • Dexamethasone did not inhibit ICAM-1 expression in neuroblastoma cells. (elsevier.com)
  • Conclusions: ICAM-1 induced in nerves by antigen challenge and proinflammatory cytokines is sensitive to dexamethasone. (elsevier.com)
  • ICAM-1 expression is also sensitive to inhibitors of NF-κB. (elsevier.com)
  • Neuroblastoma cells mimic many, but not all, characteristics of ICAM-1 expression in parasympathetic nerves. (elsevier.com)
  • Clinical implications: Dexamethasone and NF-κB inhibitors could prevent eosinophils from adhering to nerves by blocking ICAM-1 expression on parasympathetic nerves, thus protecting inhibitory M2 muscarinic receptors and making this pathway a potential target for asthma treatment. (elsevier.com)
  • Intercellular adhesion molecule-1 (ICAM-1) is known to play a role in immunity against bladder cancer and can be detected in the supernatants of cultured bladder cancer cells that constitutively express ICAM-1. (ncku.edu.tw)
  • This study was performed to examine the relevance of the ICAM-1 urine test in patients with bladder cancer. (ncku.edu.tw)
  • Urinary ICAM-1 (uICAM-1) levels were measured by immunoassay and corrected for hydration status. (ncku.edu.tw)
  • Our results suggest that urinary excretion of ICAM-1 is elevated in the early stage of bladder carcinogenesis, but is independent of biologic properties of bladder cancer. (ncku.edu.tw)
  • To identify functional synergy between selectin and Ig family members, mice deficient in both L-selectin and intercellular adhesion molecule 1 (ICAM-1) were generated. (duke.edu)
  • Leukocyte rolling velocities in cremaster muscle venules were increased significantly in ICAM-1-deficient mice during both trauma- and tumor necrosis factor alpha-induced inflammation, but rolling leukocyte flux was not reduced. (duke.edu)
  • Elimination of ICAM-1 expression in L-selectin-deficient mice resulted in a sharp reduction in the flux of rolling leukocytes during tumor necrosis factor alpha-induced inflammation. (duke.edu)
  • The observed differences in leukocyte rolling behavior demonstrated that ICAM-1 expression was required for optimal P- and L-selectin-mediated rolling. (duke.edu)
  • Increased leukocyte rolling velocities presumably translated into decreased tissue emigration because circulating neutrophil, monocyte, and lymphocyte numbers were increased markedly in L-selectin/ICAM-1-deficient mice. (duke.edu)
  • Furthermore, neutrophil emigration during acute peritonitis was reduced by 80% in the double-deficient mice compared with either L-selectin or ICAM-1-deficient mice. (duke.edu)
  • Intercellular adhesion molecule-1 (ICAM-1) works as one of the ligands for activating the killing activity of natural killer (NK) cells and cancer specific cytotoxic T lymphocytes (CTL). (elsevier.com)
  • Expression of ICAM-1 enhances lymphocyte adhesion to the cancer cells in vivo. (elsevier.com)
  • Cancer cell lines express significantly lower level of ICAM-1 than that of normal epithelium or benign cells. (elsevier.com)
  • Flow cytometry analysis results demonstrate that LIGHT gene expression in cancer cells can greatly increase ICAM-1 expression level, IFNγ alone can stimulate cancer cells to express ICAM-1, which can be highly augmented by LIGHT in a dose-dependent manner. (elsevier.com)
  • This upregulation of ICAM-1 expression is not only at ICAM-1 protein trafficking level on cell surface as demonstrated by flow cytometry analysis, but also at ICAM-1 total protein level as confirmed by Western blot. (elsevier.com)
  • It was confirmed that LIGHT enhancement upregulation of ICAM-1 expression is at least STAT1 and JAK1 dependent by using STAT1-deficient U3A and JAK1-deficient E2A4 cells. (elsevier.com)
  • These findings suggest that LIGHT-induced inhibition of tumor growth is highly correlated with its upregulation of ICAM-1 expression. (elsevier.com)
  • Inclusion of a hydroxamate metalloproteinase inhibitor partially reversed the effects on ICAM-1 and sICAM-1 at 8 h, whereas TIMP-1, -2 or -3 had no effect. (ox.ac.uk)
  • MMP-9, but not MMP-2, co-immunoprecipitated with ICAM-1. (ox.ac.uk)
  • sICAM-1 was processed distal to Arg441, indicating that MMP-9, docking to ICAM-1, contributes to sICAM-1 shedding and attenuation of the shear stress-induced upregulation of ICAM-1. (ox.ac.uk)
  • Cloning of an interferon-gamma regulated human melanoma-associated antigen: identity to the intercellular adhesion molecule ICAM-1. (unil.ch)
  • The Txnip-TRX interaction can produce multiple processes consequently including increasing intracellular ROS [ 9 - 11 ], activating stress signaling pathway of apoptosis signal-regulating kinase 1 (ASK-1), increasing intercellular adhesion molecule 1 (ICAM-1) expression, and finally resulting in endothelial dysfunction [ 10 , 12 - 14 ]. (hindawi.com)
  • Here, we identified intercellular adhesion molecule-1 (ICAM-1) as a molecule with expression coordinately regulated with Fas and inversely correlated with malignant phenotype between matched pairs of differentially aggressive malignant subpopulations in three mouse models. (elsevier.com)
  • To determine whether coordinate expression of Fas and ICAM-1 regulated malignant behavior, tumor sublines were produced that expressed either lower levels of both Fas and ICAM-1, lower levels of Fas, or lower levels of ICAM-1 and then assessed for metastatic lung tumor growth. (elsevier.com)
  • Tumor sublines rendered both Fas incompetent and ICAM-1 incompetent displayed significantly higher numbers of tumor nodules compared with tumor sublines separately expressing low levels of Fas or ICAM-1. (elsevier.com)
  • However, all tumor sublines regardless of their Fas and ICAM-1 levels comparably infiltrated the lung, suggesting that Fas- and ICAM-1-based interactions ultimately influenced lung colonization efficiency. (elsevier.com)
  • Overall, these data suggested that both Fas and ICAM-1 pathways cooperated to regulate tumor progression and that the coordinate down-regulation of Fas and ICAM-1 intensified malignant progression at the level of colonization. (elsevier.com)
  • Thus, a FaS lo ICAM-1 lo phenotype may be characteristic of at least certain advancing, immune-resistant neoplastic subpopulations. (elsevier.com)
  • We recently reported that cross-linking the leukocyte common antigen (CD45) can rapidly induce aggregation of human peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) interactions. (ashpublications.org)
  • We conclude that cross-linking the leukocyte common antigen on T cells induces LFA-1--/ICAM-1--dependent T-cell--monocyte aggregation through a unique signaling pathway independent of PKC, which involves instead cAMP-/cGMP-dependent protein kinases. (ashpublications.org)
  • Of these adhesion molecules, expression of intercellular adhesion molecule-1 ( ICAM-1 ) have been identified in colon cancer , bladder cancer , lung cancer , melanoma , pancreatic cancer , hepatocellular carcinoma . (bvsalud.org)
  • Serum sICAM-1 was measured in 84 patients with lung cancer according to the pathologic types and clinical staging using ICAM-1 ELISA kit. (bvsalud.org)
  • Objective To explore the expression of intercellular adhesion molecule-1 ( ICAM-1 ) in the brain edema induced by lipoposacchride(LPS) in rats under the action of dexamethasone . (bvsalud.org)
  • The aim of this study was to determine whether intercellular adhesion molecule-1 (ICAM-1) polymorphisms are associated with susceptibility to vasculitis or rheumatoid arthritis (RA). (elsevier.com)
  • Meta-analyses were performed to assess the associations between K469E and G241R polymorphisms of ICAM-1 and vasculitis or RA. (elsevier.com)
  • In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis. (elsevier.com)
  • To evaluate the specific role of ICAM-1 in host responses against endodontic infection . (bvsalud.org)
  • Apical periodontitis was experimentally induced in the mandibular first molars of ICAM-1 knockout and wild-type (WT) mice by pulp exposure to the oral environment . (bvsalud.org)
  • Compared to WT mice , ICAM-1 knockout mice had significantly greater bone resorption (P neutrophils to periapical inflammatory tissues (P fibroblasts (P (bvsalud.org)
  • The osteoclast number was significantly higher in ICAM-1 KO than that of WT animals at all times (P cementoclasts . (bvsalud.org)
  • Tissue levels of INF-γ were significantly lower in ICAM-1 KO than those in WT mice (P (bvsalud.org)
  • ICAM-1 deficiency impaired the host response against endodontic infection , resulting in increased tissue destruction. (bvsalud.org)
  • strong class="kwd-title" Keywords: Belly neoplasms, Intercellular adhesion molecule-1, E-selectin Introduction The adhesion between endothelial cells and malignancy cells is essential for malignancy invasion and this process is usually mediated by intercellular adhesion substances including intercellular adhesion molecule-1 (ICAM-1) and E-selectin. (exemestane.info)
  • 4) Therefore, some research workers have got reported a poor relationship between ICAM-1 expression in cancers 17-AAG tumor and cells progression or metastasis. (exemestane.info)
  • ICAM-1, which suppresses the function of immune system cells by binding to lymphocytes, may become some sort of immunosuppressive product. (exemestane.info)
  • 7-9) Therefore, with regards to the relationship between cancer ICAM-1 and cells, other researchers possess reported that elevation of ICAM-1 17-AAG expression in cancer cells and increased release of serum ICAM-1 from cancer cells are related to cancer progression or metastasis. (exemestane.info)
  • 16) In gastric cancers, some researchers possess reported a detrimental relationship between ICAM-1 expression in gastric cancers cells and tissue and cancers development or metastatic potential that includes a better prognostic impact. (exemestane.info)
  • 17,18) In any other case, others possess reported an optimistic relationship between serum degrees of circulating ICAM-1, E-selectin and their expression in gastric cancer tumor and cells progression and metastatic potential, that includes a poor prognostic effect. (exemestane.info)
  • 19-22) In today's study, the authors investigated the expression of ICAM-1 and E-selectin in gastric cancers tissue and cultured gastric cancers cells, and examined their prognostic value in gastric malignancy patients. (exemestane.info)
  • To investigate the effect of Panax notoginseng saponins (Pns) on the expression of intercellular adhesion molecule-1 (ICAM-1) and brain neutrophil infiltration induced by transient focal cerberal ischemia and reperfusion in rats. (qxmd.com)
  • At 24 h after reperfusion, neutrophil infiltration and the expression of intercellular adhesion molecule-1 (ICAM-1) were measured with myeloperoxidase (MPO) activity, and immunohistochemistry, respectively. (qxmd.com)
  • After ischemia reperfusion, the expression of ICAM-1 and MPO activity in the ischemic hemisphere cortex of MCA area and caudate putamen were markedly increased. (qxmd.com)
  • Treatment with 50 mg/kg Pns inhibited neutrophil infiltration and the expression of ICAM-1. (qxmd.com)
  • Pns inhibited neutrophil infiltration and the expression of ICAM-1 following focal cerebral ischemia-reperfusion in rats, attenuated the ischemic brain inflammation. (qxmd.com)
  • Effects of dipfluzine on expressions of E-selectin, P-selectin, and ICAM-1 in brain ischemia-reperfusion rats]. (qxmd.com)
  • Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. (qxmd.com)
  • Plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6), secretory phospholipase A2 group IIA (sPLA2-IIA), and intercellular adhesion molecule-1 (ICAM-1) were measured on days 1 and 4 and after 3 and 30 months. (diva-portal.org)
  • ICAM-1 correlated with the development of congestive heart failure. (diva-portal.org)
  • ICAM-1 seems to reflect other aspects of the inflammatory processes than the other markers. (diva-portal.org)
  • In this study, we investigated the ability of the major envelope glycoprotein of HIV, glycoprotein 120 (gp120), to regulate intercellular adhesion molecule-1 (ICAM-1) expression in glial cells, because ICAM-1 is important in mediating immune responsiveness in the CNS, facilitating entry of HIV-infected cells into the CNS, and promoting syncytia formation. (elsevier.com)
  • Our results indicate that gp120 enhances ICAM-1 gene expression in primary rat astrocytes, primary human astrocytes, a human astroglioma cell line CRT, and primary rat microglia. (elsevier.com)
  • The signal transduction events involved in gp120-mediated enhancement of ICAM-1 appear to involve activation of both protein kinase C and tyrosine kinase, because inhibitors of protein kinase C and tyrosine kinase abrogate gp120-mediated ICAM-1 expression in both astrocytes and microglia. (elsevier.com)
  • We also demonstrate that gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/β 2 integrin-dependent fashion. (elsevier.com)
  • Interleukin (IL)-18 was identified as an interferon (IFN)-γ-inducing factor and was demonstrated to up-regulate the expression of intercellular adhesion molecule (ICAM)-1 on human monocytes. (elsevier.com)
  • We measured the expression of ICAM-1 on human monocytes in MLR in the presence or absence of IL-18 by flow cytometer and determined the associated production of IFN-γ and IL-12 by ELISA. (elsevier.com)
  • The expression of ICAM-1 on monocytes in MLR was markedly enhanced by the addition of IL-18 in a concentration- and time-dependent manner. (elsevier.com)
  • In parallel to ICAM-1 up-regulation, IL-18 significantly enhanced the production of IFN-γ and IL-12 in MLR. (elsevier.com)
  • Histamine concentration-dependently inhibited ICAM-1 expression and cytokine production in MLR stimulated with IL-18, whereas histamine alone did not show any effects on these responses in the absence of IL-18. (elsevier.com)
  • The effects of histamine on both ICAM-1 expression and cytokine production were mimicked by the selective H2-receptor agonists 4-methylhistamine and dimaprit and were antagonized by the H2-receptor antagonist famotidine but not by H1- and H3-receptor antagonists. (elsevier.com)
  • IL-18 strongly enhanced human MLR with respect to ICAM-1 expression and cytokine production. (elsevier.com)
  • Isogai N, Tanaka H, Asamura S. Thrombosis and altered expression of intercellular adhesion molecule-1 (ICAM-1) after avulsion injury in rat vessels. (ijconline.id)
  • We examined the effects of endogenous catecholamines and β2-AR agonists on the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) in human mixed lymphocyte reaction (MLR) and in an in vitro model of acute rejection in the presence or absence of IL-18. (elsevier.com)
  • ICAM-1, B7.1 B7.2, CD40, and CD40L expression on monocytes was measured by flow cytometry, and the production of interferon (IFN)-γ and IL-12 was determined by enzyme-linked immunosorbent assay. (elsevier.com)
  • β2-AR agonists inhibited the expression of ICAM-1 and CD40 during MLR in the absence of IL-18. (elsevier.com)
  • Among IL-18-induced expression of ICAM-1, B7.1, B7.2, CD40, and CD40L, β2-AR agonists inhibited ICAM-1 and CD40 expression. (elsevier.com)
  • We found that β2-AR agonists strongly inhibited the expression of ICAM-1 and CD40, irrespective of the presence or absence of IL-18, which is different from that of histamine and prostaglandin E2. (elsevier.com)
  • Initially, this pipeline guide covers intercellular Adhesion Molecule 1 (ICAM-1) overview along with precise information on its therapeutic development. (bizpr.co.uk)
  • In addition to targeting ICAM-1, alicaforsen has been shown to target Toll-like receptor 9 (TLR-9). (bizpr.co.uk)
  • The ICAM family consists of five members, designated ICAM-1 to ICAM-5. (bizpr.co.uk)
  • In the aerobic training group, comparison within groups showed, serum levels of ICAM-1, VCAM-1 and CRP (respectively P=0.001, P=0.001 and P=0.001) were significantly reduced. (ac.ir)
  • Aerobic exercise with reducing levels of inflammatory markers ICAM-1 and CRP may play an important role in the prevention and control of cardiovascular diseases in middle-aged men with heart failure. (ac.ir)
  • To Investigate the significance of Intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antlgen-1 (LFA-1) In host defense against infection with Intracellular parasites, we examined the effects of In vivo pretreatment with mAbs to ICAM-1 (1A29) and LFA-1α (WT-1) on the protection against Infection with Listeria monocytogenesIn Fisher F344/N rats. (elsevier.com)
  • Expression of ICAM-1 and LFA-1α molecules on T cells In spleen, liver and peritoneal cavity of rats was down-regulated after i.p. administration with daily doses of 300 μg of either 1A29 or WT-1 for 10 days. (elsevier.com)
  • Thus, the resistance against llsterial Infection was severely Impaired by combinational pretreatment with mAbs In ICAM-1 and LFA-1α. (elsevier.com)
  • These results suggest that the ICAM-1 and LFA-1 adhesion pathway may be critically involved in protectlve roles of CD3 + TCR αβ - T cells at the early stage of rat listeriosis. (elsevier.com)
  • Rat mesangial cells were cultured with ETB or ETBP (50 μg/ml) while measuring production of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) and while examining proliferation and expression of intercellular adhesion molecule-1 (ICAM-1). (elsevier.com)
  • Cells were assessed for proliferation by incorporation of radioactive thymidine and expression of ICAM-1 was measured by indirect immunofluorescence and by cellular ELISA. (elsevier.com)
  • Immunofluorescence studies revealed an increased expression of ICAM-1 in ETBP/ETB-treated mesangial cells. (elsevier.com)
  • Mammalian intercellular adhesion molecules include: ICAM-1 ICAM2 ICAM3 ICAM4 ICAM5 Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). (wikipedia.org)
  • ICAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. (wikipedia.org)
  • ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. (wikipedia.org)
  • The structure of ICAM-1 is characterized by heavy glycosylation, and the protein's extracellular domain is composed of multiple loops created by disulfide bridges within the protein. (wikipedia.org)
  • The dominant secondary structure of the protein is the beta sheet, leading researchers to hypothesize the presence of dimerization domains within ICAM-1. (wikipedia.org)
  • LFA-1 has also been found in a soluble form, which seems to bind and block ICAM-1. (wikipedia.org)
  • ICAM-1 is an endothelial- and leukocyte-associated transmembrane protein long known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. (wikipedia.org)
  • More recently, ICAM-1 has been characterized as a site for the cellular entry of human rhinovirus. (wikipedia.org)
  • Because of these associations with immune responses, it has been hypothesized that ICAM-1 could function in signal transduction. (wikipedia.org)
  • ICAM-1 ligation produces proinflammatory effects such as inflammatory leukocyte recruitment by signaling through cascades involving a number of kinases, including the kinase p56lyn. (wikipedia.org)
  • ICAM-1 and soluble ICAM-1 have antagonistic effects on the tight junctions forming the blood-testis barrier, thus playing a major role in spermatogenesis. (wikipedia.org)
  • The presence of heavy glycosylation and other structural characteristics of ICAM-1 lend the protein binding sites for numerous ligands. (wikipedia.org)
  • ICAM-1 possesses binding sites for a number of immune-associated ligands. (wikipedia.org)
  • As a result of these binding characteristics, ICAM-1 has classically been assigned the function of intercellular adhesion. (wikipedia.org)
  • Researchers began to question the role of ICAM-1 as a simple adhesion molecule upon discovering that ICAM-1 serves as the binding site for entry of the major group of human rhinovirus (HRV) into various cell types. (wikipedia.org)
  • ICAM-1 also became known for its affinity for plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role for ICAM-1 in infectious disease. (wikipedia.org)
  • With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 in signal transduction was hypothesized. (wikipedia.org)
  • Most of the work involving ICAM-1 in recent years has focused on this central question as well as related questions. (wikipedia.org)
  • Researchers reasoned that, should ICAM-1 signal transduction prove to occur, it would be necessary to identify the mechanism of that signaling, the conditions and environment in which the signaling would occur, and the biological endpoints of any signaling cascades involved. (wikipedia.org)
  • Beyond its classically described functions as an adhesion and viral entry molecule, ICAM-1 has now been characterized convincingly as possessing a role in signal transduction. (wikipedia.org)
  • Furthermore, the signal-transducing functions of ICAM-1 seem to be associated primarily with proinflammatory pathways. (wikipedia.org)
  • In particular, ICAM-1 signaling seems to produce a recruitment of inflammatory immune cells such as macrophages and granulocytes. (wikipedia.org)
  • ICAM-1 may also participate in a positive feedback loop and compete with ICAM-2 to maintain a proinflammatory environment conducive to leukocyte endothelial transmigration. (wikipedia.org)
  • At both the mRNA and protein levels of expression, ICAM-1 ligation was found to upregulate ICAM-1's own expression in a positive-feedback loop. (wikipedia.org)
  • In addition, the expression of RANTES mRNA and protein was also found to be upregulated by ICAM-1 ligation. (wikipedia.org)
  • In addition, TNF has been shown to up-regulate adhesion molecules that participate in cellular recruitment and lymphocyte activation. (jimmunol.org)
  • In mycosis fungoides the malignant T cells express lymphocyte function-associated antigen-1, which allows them to bind to epidermal keratinocytes expressing the gamma interferon-inducible intercellular adhesion molecule-1. (semanticscholar.org)
  • Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells in Graves' and Hashimoto's diseases. (ox.ac.uk)
  • sICAM-1 levels in B-CLL were positively correlated to the tumor mass as reflected by the modified Rai and the Binet staging systems, lymphocyte counts, and isolated spleno/hepatomegaly. (ashpublications.org)
  • sICAM-1 was also correlated to a kinetic parameter such as the lymphocyte doubling time. (ashpublications.org)
  • sICAM-1 was equally well or better correlated to clinical stage and lymphocyte doubling time. (ashpublications.org)
  • In univariate regression analysis, all serum markers but LDH correlated with survival, and in multivariate analysis, sICAM-1 was the only marker approaching significance for additional prognostic information when included after clinical stage and lymphocyte doubling time. (ashpublications.org)
  • However, the potential shortcomings of using antibodies administered in vivo to investigate the role of these adhesion molecules have not been fully discussed. (physiology.org)
  • For example, antibodies can have actions other than simply blocking the functional expression of their respective adhesion molecules: they may help attenuate liver injury by inhibiting complement activation ( 11 ). (physiology.org)
  • Therefore, there is a need to investigate not only the in vivo administration of antibodies against adhesion molecules, but also the expression profiles of these adhesion molecules in the development of liver injury. (physiology.org)
  • Effects of alpha-tocopherol on superoxide production and plasma intercellular adhesion molecule-1 and antibodies to oxidized LDL in chronic smokers. (ru.nl)
  • Despite those studies, it is still unknown whether the effect of GC31 on EIU is mediated by inhibiting leukocyte-endothelium adhesion. (molvis.org)
  • Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium. (ox.ac.uk)
  • 10-12) Selectins are adhesion molecules that mediate the original binding of leukocytes to microvascular endothelium by lectin-type interactions with carbohydrate ligands in matching target cells. (exemestane.info)
  • CD54) is a cell adhesion molecule of immunoglobulin (Ig) superfamily expressed by several cell types including leukocytes and endothelial cells with critical involvement in arrest and transmigration of leukocytes from blood vessels into tissues. (springer.com)
  • Abstract- As distal targets and mediators of signal transduction pathways, activator protein-1 (AP-1), c-Jun, and c-Fos are among the primary regulators of genes involved in cell function, proliferation, and differentiation. (ahajournals.org)
  • Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. (termedia.pl)
  • Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. (duke.edu)
  • Using 2-photon laser scanning microscopy and contrast-enhanced ultrasound, intercellular adhesion molecule-1-targeted and rhodamine-loaded microbubbles were shown to be specifically bound to tumor necrosis factor-α-stimulated human umbilical vein endothelial cells and murine carotid arteries (44 wild-type mice) at shear stresses ranging from 1.25 to 120 dyn/cm(2). (nih.gov)
  • A positive correlation of sICAM-1 serum concentrations and tumor stage in CRC was described for example by Mantur et al. (springer.com)
  • Our objectives were to correlate these levels with clinicopathological features, established tumor markers, and patient survival, and to assess changes in serum levels of cell adhesion molecules after tumor surgery. (nih.gov)
  • To examine the regulatory mechanism in the suppression of serum sICAM-1 levels, serum interleukin-6 (IL-6) levels and serum tumor necrosis factor-alpha (TNF-alpha) levels were measured by ELISA.All serum IL-6 levels were under the detectable level, and TNF-alpha levels were depressed within 1 hour of anesthesia in 30% of patients, though serum TNF-alpha levels did not correlate with serum sICAM-1 levels. (nii.ac.jp)
  • Our results suggest that anesthesia promote the attachment of cytotoxic cells to tumor cells by suppression of serum sICAM-1 level, consequently tumor cell destruction may occur especially in the patients with matastasis. (nii.ac.jp)
  • Liu C, Qu L, Zhao C, Shou C. Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion. (eurekaselect.com)
  • Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. (elsevier.com)
  • The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively). (elsevier.com)
  • Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer. (elsevier.com)
  • Levels of uICAM-1 were significantly elevated in patients with bladder cancer or those at tumor-free status compared with normal control subjects (P=0.001). (ncku.edu.tw)
  • Six patients at tumor-free status had multiple uICAM-1 determinations during the study period. (ncku.edu.tw)
  • Serial monitoring of uICAM-1 may be helpful in selecting patients who are at risk of tumor recurrence. (ncku.edu.tw)
  • And no difference was observed among histologic tumor types with regard to sICAM-1 concentration. (bvsalud.org)
  • The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-12 months survival than the negative group (54.9 vs. 85.9%, respectively). (exemestane.info)
  • Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines. (bmj.com)
  • However, the regulatory effects of AP-1 proteins in human ECs remain unclear. (ahajournals.org)
  • It is not known whether AP-1 proteins are sufficient to induce phenotypic changes or whether they must act in concert with other effectors. (ahajournals.org)
  • Dånmark S, Finne-Wistrand A, Albertsson AC, Patarroyo M, Mustafa K. Integrin-mediated adhesion of human mesenchymal stem cells to extracellular matrix proteins adsorbed to polymer surfaces. (eurekaselect.com)
  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. (genecards.org)
  • More recent studies, however, have begun to expand long-standing concepts and to examine the roles of other proteins such as intercellular adhesion molecules. (thecannabisadvisory.com)
  • 2. Proteins extraction and traditional western blot analysis To get the intestinal protein, cells and tissue had been homogenized in RIPA buffer (20 mM Tris, 1 mM EDTA, 255 mM sucrose, pH 7.1). (exemestane.info)
  • Effect of upper-and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. (ac.ir)
  • Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1. (springer.com)
  • Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. (nih.gov)
  • 1,2) A couple of three distinctive steps along the way of cancers cell metastasis, including detachment from the cancers cells from the principal lesion, penetration through the tissues basement membrane, invasion of bloodstream migration 17-AAG and vessels to the mark body organ. (exemestane.info)
  • Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). (nih.gov)
  • Gottrand G, Courau T, Thomas-Vaslin V, Prevel N, Vazquez T, Ruocco MG, Lambrecht B, Bellier B, Colombo BM, Klatzmann D. Regulatory T-cell development and function are impaired in mice lacking membrane expression of full length intercellular adhesion molecule-1. (springer.com)
  • The IgSF integrin ligands play specific and in some cases overlapping roles in leukocyte recirculation and recruitment at sites of inflammation, antigen-specific T cell responses and other cell-cell interactions essential for immune surveillance ( 1 ). (pnas.org)
  • To understand the molecular basis for recognition by integrins of cell adhesion molecules, it is important to map the recognition surfaces. (pnas.org)
  • We investigated the effect of Egfl7 on endothelial cell intercellular adhesion molecule 1 expression in response to H/R injury. (ahajournals.org)
  • Hypoxia/reoxygenation (H/R), which simulates ischemia/reperfusion (I/R) in a cell culture model, is known to injure endothelial cells through oxidant production, 1 which leads to the production of inflammatory cytokines 2,3 and activates inflammatory cell signaling pathways. (ahajournals.org)
  • This study evaluated serum concentrations of soluble cell adhesion molecules in patients with gastric cancer and in healthy control subjects. (nih.gov)
  • For example, the sites of action for PS ODN are the cytoplasm and nucleus, but in vitro these molecules can penetrate very few cell types unaided. (aspetjournals.org)
  • Neutrophil recruitment at sites of inflammation is mediated by a variety of adhesion molecules, which are cell-surface glycoproteins involved in cell-cell and cell-matrix interactions. (physiology.org)
  • The activation of CD99 inhibits cell-extracellular matrix adhesion by suppressing β(1) integrin affinity. (eurekaselect.com)
  • Comparative analysis of the expression of cell adhesion molecules in cutaneous T-cell lymphomas (mycosis fungoides/Sézary syndrome) and inflammatory skin diseases]. (semanticscholar.org)
  • Dysregulated synthesis of intracellular type 1 and type 2 cytokines by T cells of patients with cutaneous T-cell lymphoma. (semanticscholar.org)
  • J Cell Biol (1988) 107 (1): 321-331. (rupress.org)
  • Adhesion of JY B lymphoblastoid cells, normal and genetically LFA-1 deficient T lymphoblasts and resting peripheral blood lymphocytes to endothelial cell monolayers was also assayed. (rupress.org)
  • In summary, LFA-1 dependent (60-90% of total adhesion) and LFA-1-independent basal adhesion was observed and the use of both adhesion pathways by different interacting cell pairs was increased by monokine or lipopolysaccharide stimulation of endothelial cells. (rupress.org)
  • Many evidences have indicated the presence of many cell adhesion molecules and growth factors in atherosclerosis. (biomedcentral.com)
  • Various studies have showed there are many inflammatory markers that can predict cardiovascular events, including cell adhesion molecules, cytokines, chemokines, acute phase reactants such as fibrinogen, serum amyloid A and CRP. (biomedcentral.com)
  • If germ cell adhesion were to be compromised for a period of time longer than usual, germ cells would slough the seminiferous epithelium and infertility would result. (thecannabisadvisory.com)
  • Presently, Sertoli-germ cell adhesion is known to be mediated largely by classical and desmosomal cadherins. (thecannabisadvisory.com)
  • Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. (ox.ac.uk)
  • The role of thrombospondin in cell adhesion, in vitro or in vivo, is less certain. (ox.ac.uk)
  • To screen for alternative receptors, we have developed a novel cell-adhesion assay using transfected COS cells, which confirms that CD36 is a cell-adhesion receptor. (ox.ac.uk)
  • Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. (elsevier.com)
  • Adhesion molecule is related to cell - cell interaction and inflammatory interaction. (bvsalud.org)
  • The overall survival of patients with low sICAM-1 concentration (or=306 ng/mL) in non-small cell lung cancer patients , but no difference was observed in small cell lung cancer patients . (bvsalud.org)
  • These results suggest that high levels of sICAM-1 reflect the poor prognosis of patients with non-small cell lung cancer . (bvsalud.org)
  • Endothelial cell dysfunction has been implicated in the inflammatory response to cardiopulmonary bypass, and the upregulation of endothelial cell expression of adhesion molecules might promote leukocyte extravasation in vivo. (bairdinstitute.org.au)
  • Soluble endothelial cell adhesion molecules are increased after bypass. (bairdinstitute.org.au)
  • The aim of this study was to investigate the relationship between endothelial cell-surface expression of adhesion molecules and their concentration in plasma after coronary artery bypass grafting. (bairdinstitute.org.au)
  • Purpose Among cell adhesion molecules, serum degrees of intercellular adhesion molecule-1 and E-selectin are regarded as correlated with the metastatic potential of gastric cancer. (exemestane.info)
  • 3) Regarding the detachment of cancers cells, a rise in metastatic potential continues to be reported combined with the reduced amount of cell adhesion substances. (exemestane.info)
  • Compared with controls, treatment with either ETBP or ETB significantly increased MCP-1 and MIP-2 levels in mesangial cell cultures. (elsevier.com)
  • Intercellular adhesion molecule-1-targeted and rhodamine-loaded microbubbles bound 8× more efficient (P=0.016) to stimulated human umbilical vein endothelial cells than to unstimulated cells and 14× more than nontargeted microbubbles (P=0.016). (nih.gov)
  • Conclusions- Our study reveals the novel observation that hypoxia upregulates human coronary artery endothelial cells expression of Egfl7 and that Egfl7 inhibits expression of intercellular adhesion molecule 1 subsequent to H/R injury. (ahajournals.org)
  • Human umbilical vein endothelial cells (HUVECs) were incubated with LPS (1 μg/ml) and peptide GC31 or control peptide VP30 simultaneously. (molvis.org)
  • The adhesion of U937 cells labeled with CM-H2DCFDA to HUVECs was examined with fluorescence microscope. (molvis.org)
  • 1 2 3 4 Along with the excessive proliferation of intimal smooth muscle cells, leukocyte infiltration is a major histological feature of flow-limiting stenoses in saphenous vein bypass grafts. (ahajournals.org)
  • Changes in SECs have been reported ( 1 , 15 ) to occur early in reperfusion, so these cells are thought to be the primary targets of this injury. (physiology.org)
  • The in vitro expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on biliary epithelial cells was studied in response to tumour necrosis factor-alpha (0-500 U/ml), interferon-gamma (0-500 U/ml), and interleukin-1 (0-5 U/ml) by immunohistochemical staining and a semiquantitative scoring system validated by spectrophotometry and previously validated by laser confocal microscopy. (bmj.com)
  • The non-stimulated expression of intercellular adhesion molecule-1 and HLA class II was higher on cells derived from the primary biliary cirrhosis liver than on cells from normal liver, a difference not seen with HLA class I expression. (bmj.com)
  • A statistically significant increase in intercellular adhesion molecule-1 expression was seen with all three cytokines in cells derived from both primary biliary cirrhosis and normal liver. (bmj.com)
  • Increase in HLA class I expression was seen only with interleukin-1 5 U/ml for cells derived from both normal and diseased liver. (bmj.com)
  • These data show that pro-inflammatory cytokines increase expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on human intrahepatic biliary epithelial cells in vitro and are consistent with the hypothesis that these locally acting factors may play a part in the pathogenesis of immune mediated disorders such as primary biliary cirrhosis in which immune mediated bile duct damage occurs. (bmj.com)
  • Effects of pentoxifylline and protein kinase C inhibitor on phorbol ester-induced intercellular adhesion molecule-1 expression in brain microvascular endothelial cells. (chinaphar.com)
  • Mimicking bone extracellular matrix: integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. (eurekaselect.com)
  • These adhesion events are necessary for normal immune function and may facilitate the emigration of proinflammatory cells from the circulation to extravascular sites of inflammation . (ccsu.edu)
  • In addition, we find that an endothelial-binding line of P. falciparum binds to COS cells transfected with a complementary DNA encoding intercellular adhesion molecule-1. (ox.ac.uk)
  • In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer. (elsevier.com)
  • Materials and Methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. (elsevier.com)
  • Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. (elsevier.com)
  • Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. (elsevier.com)
  • In 1995, a milestone study demonstrated psoriatic plaque resolution following selective apoptosis of activated T cells, without affecting KC survival or activation, thus demonstrating the crucial role of the immune system, particularly of T cells, in the disease [ 1 ]. (mdpi.com)
  • Liu, K , Caldwell, SA & Abrams, SI 2005, ' Cooperative disengagement of fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency ', Cancer Research , vol. 65, no. 3, pp. 1045-1054. (elsevier.com)
  • Moreover, gp120 induces tyrosine phosphorylation of signal transducer and activator of transcription (STAT-1α) as well as the Janus kinase (JAK2) in glial cells. (elsevier.com)
  • Benveniste, Etty N. / HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells : Involvement of janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways . (elsevier.com)
  • Higher flow rates (0.8 and 1 mL/min) showed significantly reduced microbubbles retention, by 38% (P=0.03) and 55% (P=0.03), respectively. (nih.gov)
  • Neither hsCRP, nor the adhesion molecules were significantly related to carotid artery IMT. (diva-portal.org)
  • The results showed a significant high level of HA and sICAM-1 in all groups compared to G4, while a significantly high level of HA in G2 compared to G3. (omicsonline.org)
  • Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml -1 ) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). (elsevier.com)
  • It was found that compared to nonsmokers (n = 33) plasma levels of IgG but not IgM autoantibodies against oxLDL and concentrations of sICAM-1 in smokers were significantly elevated (30 and 42%, respectively). (ru.nl)
  • The survival rate of rats inoculated with viable Listeria was significantly reduced byIn vivo pretreatment with 1A29 together with WT-1 for 10 days but not by In vivo pretreatment with control mAb. (elsevier.com)
  • The numbers of bacteria In the spleen In rats pretreated with both 1A29 and WT-1 were significantly increased on day 3 and day 6 after Infection with 1 × 10 7 of viable Listeria corresponding to 1/30 of LD 50 to normal rats. (elsevier.com)
  • In inflammatory bowel disease, the distribution of intercellular adhesion molecule 1 genotypes was 24.9% E/E, 44.2% E/K and 30.9% K/K. In controls, 11.8% showed E/E genotype, 55.6% E/K and 32.6% K/K. The frequency of the E/E genotype was significantly higher in inflammatory bowel disease (Crohn's disease and ulcerative colitis) patients than in controls. (elsevier.com)
  • 5 In ECs, AP-1 activity can be induced by a variety of factors, such as cytokines, 6 bacterial endotoxin, antioxidants, 7 hypoxia, 8 fluid shear stress, 9 10 11 and LDL. (ahajournals.org)
  • 6. Libby P, Ross R. Cytokines and growth regulatory molecules. (ac.ir)
  • Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. (springer.com)
  • Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. (jimmunol.org)
  • The anti-inflammatory activity of free and liposome-encapsulated oligonucleotide targeted against intercellular adhesion molecule-1 mRNA was investigated in a delayed type hypersensitivity model of acute inflammation in mice. (aspetjournals.org)
  • These data demonstrate the utility of liposome-encapsulated intercellular adhesion molecule-1 antisense oligonucleotide as a novel anti-inflammatory therapeutic. (aspetjournals.org)
  • Other reports have stressed that there are interactions between the adhesion molecules and growth factors in inflammatory responses. (biomedcentral.com)
  • Psoriasis (Ps) and psoriatic arthritis (PsA) belong to the family of immune mediated inflammatory diseases (IMID) predominantly affecting skin and joints ( 1 ). (frontiersin.org)
  • Intercellular adhesion molecule 1 plays an important role in the recruitment of leucocytes at sites of inflammation and is up-regulated in intestinal mucosa of inflammatory bowel disease. (elsevier.com)
  • Intercellular adhesion molecule 1 gene lies on chromosome 19p13, implicated in determining susceptibility to inflammatory bowel disease. (elsevier.com)
  • We found an association of inflammatory bowel disease with the E/E genotype of intercellular adhesion molecule 1 gene, while allele E469 was associated with a subgroup of Crohn's disease patients with more extensive location of disease and penetrating behaviour. (elsevier.com)
  • Extracellular signal-regulated kinase-1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) activation, inhibitor of nuclear factor kappa B alpha (IκBα) degradation, and nuclear factor kappa B (NF-κB) nuclear translocation were detected with western blot. (molvis.org)
  • 1 Although nuclear factor-κB (NF-κB) has been shown to play a pivotal role in EC activation, 2 3 4 increasing evidence indicates the importance of the transcription factor activator protein-1 (AP-1) in endothelial homeostasis and dysfunction. (ahajournals.org)
  • AP-1 is a regulatory protein complex composed of members of the Jun and Fos families. (ahajournals.org)
  • Effects of pentoxifylline and protein kinase C inhibitor on phorbol ester-induced intercellular adhesion molecule-1. (chinaphar.com)
  • Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin. (eurekaselect.com)
  • Proatherogenic inflammation markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activators monocyte chemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1 (sICAM-1), were determined by enzyme-linked immunosorbent assay. (frontiersin.org)
  • Adenosine acts through four G protein-coupled adenosine receptors that either stimulate (A 2A , A 2B ) or inhibit (A 1 , A 3 ) adenylate cyclase and thus enhance or decrease the second messenger cyclic AMP (cAMP). (nature.com)
  • Plasma soluble adhesion molecules, C-reactive protein, interleukin 8, interleukin 10, transforming growth factor beta1, and neutrophil counts were determined for each patient. (bairdinstitute.org.au)
  • Christie, J. D. / Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation . (elsevier.com)
  • During disease progression or regression on cytoreductive therapy, the circulating sICAM-1 levels changed accordingly. (ashpublications.org)
  • Levels of circulating adhesion molecules in rheumatic mitral stenosis. (ijconline.id)
  • Ex vivo results were translatable in vivo, confirming that intercellular adhesion molecule-1-targeted and rhodamine-loaded microbubbles are able to bind specifically to the inflamed carotid artery endothelia under physiological flow conditions and to be noninvasively detected using contrast-enhanced ultrasound. (nih.gov)
  • The relationship between inflammation and coagulation has been widely described, which adhesion molecules play important role in inflammation. (ijconline.id)
  • They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. (wikipedia.org)
  • The crystal structure of the I domain in LFA-1 and the related Mac-1 (CD11b/CD18) integrin has been defined and contains a Mg 2+ that is required for ligand binding ( 4 , 5 ). (pnas.org)
  • Our studies demonstrated that Ly6C(high) monocyte recruitment from the bloodstream to the L. monocytogenes-infected liver does not require chemokine receptor-mediated signals but instead is principally dependent on integrin- and extracellular matrix-mediated monocyte adhesion. (ox.ac.uk)
  • These trans -acting elements interact with AP-1 binding sites in target genes to mediate cellular responses to environmental stimuli. (ahajournals.org)
  • Although studies have established the role of integrins in bone homeostasis, especially in osteoclastogenesis, and these molecules are novel and promising therapeutic drug targets for bone loss diseases, such as: osteolysis, the cellular mechanism still elusive. (eurekaselect.com)
  • Lee, YH & Bae, SC 2016, ' Intercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: A meta-analysis ', Cellular and Molecular Biology , vol. 62, no. 12, pp. 84-90. (elsevier.com)
  • Weight reduction decreases soluble cellular adhesion molecules in obese women. (ac.ir)
  • Triple negative breast cancers (TNBCs) comprise a heterogeneous group of tumors with a diverse histology and genetic makeup that share the common feature of low expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) ( 1 ). (pnas.org)
  • Our study first shows an increase in cIMT, and in serum levels of sICAM-1 and CRP in recent-onset PsA patients not presenting conventional CVRFs over the non-medicated time-period, from disease diagnosis to the beginning of pharmacological treatment, compared with healthy subjects. (frontiersin.org)
  • Stratification by ethnicity and vasculitis type showed no association between vasculitis and 1 K469E polymorphism under heterozygote contrast. (elsevier.com)
  • Recently, the polymorphism K469E of intercellular adhesion molecule 1 gene has been identified. (elsevier.com)
  • Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. (rupress.org)
  • Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. (ox.ac.uk)
  • After supplementation with alpha-tocopherol concentration of TBARS in plasma and in vitro oxidizability of LDL had decreased, but autoantibodies and sICAM-1 had not changed. (ru.nl)
  • It is concluded that in chronic smokers, long-term treatment with alpha-tocopherol does not normalize the raised levels of sICAM-1 and autoantibodies against oxLDL, both risk factors for initiation or progression of cardiovascular disease, despite a decrease in in vitro oxidizability of LDL. (ru.nl)
  • Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM), elastase and neutrophils were assessed in bronchoalveolar lavage fluid from nine infants who developed chronic lung disease (CLD) after respiratory distress syndrome (RDS), seven who had recovered from RDS, and in four control infants. (bmj.com)
  • Effects of sodium beta-aescin on expression of adhesion molecules and migration of neutrophils after middle cerebral artery occlusion in rats. (qxmd.com)
  • Application of a novel risk score combining CEA/sICAM-1 serum concentrations allows the identification of high-risk groups for poor survival in CRC patients. (springer.com)
  • Finally, low serum concentrations in the culture medium potentiated the stimulatory effect of ETB on MCP-1 production. (elsevier.com)
  • CRP, interleukin-6, secretory phospholipase A2 group IIA, and intercellular adhesion molecule-1 during the early phase of acute coronary syndromes and long-term follow-up. (diva-portal.org)
  • Previous reports have demonstrated the presence of streptococcal erythrogenic toxin type B (ETB) as well as proliferation and expression of adhesion molecules along with leukocyte infiltrations in biopsies from patients with acute post-streptococcal glomerulonephritis (APSGN). (elsevier.com)
  • Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of. (medscimonit.com)
  • In blood samples of 297 CRC patients, sICAM-1 was determined by ELISA and CEA by microparticle enzyme immunoassay the day before oncologic resection. (springer.com)
  • After 24, 48 and 96 h of incubation, MCP-1 and MIP-2 in culture supernatants were assessed by enzyme-linked immunosorbent assay (ELISA). (elsevier.com)
  • In this review, we focus on the biology of intercellular adhesion molecules in the mammalian testis, hoping that this information is useful in the design of future studies. (thecannabisadvisory.com)
  • 12 Sequence analysis indicates that AP-1 binding sites are recurrent elements in the promoters of genes encoding adhesion molecules and chemokines. (ahajournals.org)