Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Antigens, CD29: Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)Integrin beta Chains: Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.Cell Adhesion: Adherence of cells to surfaces or to other cells.Integrin beta3: An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.Integrin alpha4: An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.Integrin alphaV: An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.Integrin alpha3: An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.Integrin alpha Chains: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.Antigens, CD18: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.Receptors, Vitronectin: Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.Integrin alphaVbeta3: An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Integrin alpha6beta1: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.Receptors, Fibronectin: Specific cell surface receptors which bind to FIBRONECTINS. Studies have shown that these receptors function in certain types of adhesive contact as well as playing a major role in matrix assembly. These receptors include the traditional fibronectin receptor, also called INTEGRIN ALPHA5BETA1 and several other integrins.Talin: A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.Integrin alpha5beta1: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.Integrin alpha1beta1: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Laminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.Dimerization: The process by which two molecules of the same chemical composition form a condensation product or polymer.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Integrin alpha6: An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Vitronectin: A blood plasma glycoprotein that mediates cell adhesion and interacts with proteins of the complement, coagulation, and fibrinolytic cascade. (From Segen, Dictionary of Modern Medicine, 1992)Integrin alpha5: This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.Integrin alpha3beta1: Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Integrin alpha2: An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Oligopeptides: Peptides composed of between two and twelve amino acids.Disintegrins: A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.Focal Adhesion Kinase 1: A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.Focal Adhesion Protein-Tyrosine Kinases: A family of non-receptor, PROLINE-rich protein-tyrosine kinases.Immunoreceptor Tyrosine-Based Activation Motif: A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.Calmodulin: A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Contrast Media: Substances used to allow enhanced visualization of tissues.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Sarcoma, Kaposi: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Antigens, CD44: Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)Intercellular Adhesion Molecule-1: A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes ... Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain ... 2002). "The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1". J. Cell Biol. 157 (3 ... 2003). "Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in ...
... , also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ... 2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52. doi:10.1161/01.ATV. ...
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and ... This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function- ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ...
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a ... integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". J. Biol ... 2006). "Integrin alpha 11 is a novel type I interferon stimulated gene". Cytokine. 33 (6): 352-61. doi:10.1016/j.cyto.2006.03. ... "Entrez Gene: ITGA11 integrin, alpha 11". Byström B, Carracedo S, Behndig AB, Gullberg D, Pedrosa-Domellof F (June 2009). "{ ...
... is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain ... CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . ... This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b ... 1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes". Leukemia. 4 (10): 682-7. PMID ...
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 ... CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. ...
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)". Tani, T T; Mercurio A M (Sep 2001). "PDZ ... Ruoslahti E (1996). "Integrin signaling and matrix assembly". Tumour Biol. 17 (2): 117-24. doi:10.1159/000217975. PMID 8658014 ...
Alpha-7 integrin is 128.9 kDa in molecular weight and 1181 amino acids in length. Integrins are heterodimeric integral membrane ... Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell- ... It was shown however that beta-1D integrin appears at embryonic day 11 and alpha-7 integrin does not appear until embryonic day ... The function of alpha-7 integrin, as is the case for most integrins is to mediate cell membrane interactions with extracellular ...
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and ... Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with ... "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2 ... "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". Park KR, Inoue T, Ueda M, Hirano T, ...
Integrin receptors exist as heterodimers, and greater than 20 different integrin heterodimeric receptors have been described. ... Integrin beta-1 is the most abundant beta-integrin expressed and associates with at least 10 different integrin-alpha subunits ... Integrin beta-1 also known as CD29 is a protein that in humans is encoded by the ITGB1 gene. CD29 is an integrin unit ... The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion. A second integrin beta-1 ...
Integrins are heterodimeric glycoprotein receptors that recognize proteins present in the extracellular matrix, like ... When adhesion through integrins do not occur the pro-apoptotic factors are not inhibited and resulting in apoptosis. The ... Consequently, the integrin αIIbβ3 is activated and the binding to fibrinogen allows the aggregation of platelets to each other ... In order to function, integrins have to form complexes with ILK and Fak proteins. For adhesion to the extracellular matrix, ILK ...
The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene. ... Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. Expression of CD49b in ...
... is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex. This gene encodes the alpha 1 subunit of ... The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 ... ITGA1 integrin, alpha 1". Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors". Cell ... 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp ...
... to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7. Like all integrin subunits, β7 is a ... Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) ... "Entrez Gene: ITGB7 integrin, beta 7". Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti- ... Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (Jan 2012). "Structural specializations of α(4)β(7), an integrin that ...
Integrin receptors are heterodimeric transmembrane glycoproteins that cluster upon ECM engagement, leading to FAK ... Chung J, Gao AG, Frazier WA (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin ... The function of the amino-terminal domain is less clear, but it has been shown to interact with the beta-1 integrin subunit in ... Xie B, Zhao J, Kitagawa M, Durbin J, Madri JA, Guan JL, Fu XY (June 2001). "Focal adhesion kinase activates Stat1 in integrin- ...
Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta ... Schnapp, L (2006). Integrin, Adhesion/cell-matrix. Seattle: Elsevier. García AJ (December 2005). "Get a grip: integrins in cell ... Integrins and the Ig-superfamily CAMs do not depend on Ca2+ while cadherins and selectins depend on Ca2+. In addition, ... integrins participate in cell-matrix interactions, while other CAM families participate in cell-cell interactions. Integrins, ...
... encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a ... Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends ... many integrins are known to facilitate signal transduction. In mammals the integrins that include alpha-V are : Overexpression ... that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta ...
It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. ... LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine ... Heterodimeric amino acid transporter GRCh38: Ensembl release 89: ENSG00000168003 - Ensembl, May 2017 GRCm38: Ensembl release 89 ...
The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell ... Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. This gene encodes an alpha integrin. Integrins are ... "The newcomer in the integrin family: integrin α9 in biology and cancer". Advances in biological regulation. 52 (2): 326-39. doi ... The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for tenascin-C, VCAM1 ...
CD103 binds integrin beta 7 (β7- ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. ... Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded ... "The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL". J. Immunol. ... "Entrez Gene: integrin". Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V, Brunner M, Scheffold A, Hamann A ( ...
... (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also ... and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins. αMβ2 is expressed on the surface of many ... Integrin alphaM at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Todd RF, Petty HR (May 1997). "Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors". The ...
ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... integrin complex. • integral component of plasma membrane. • platelet alpha granule membrane. • integral component of membrane ... 2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52. doi:10.1161/01.ATV. ...
In addition, CD97 promotes angiogenesis of the endothelium through to α5β1 and αvβ3 integrins, which contributes to cell ... Lysophosphatidylethanolamine (LPE; a plasma membrane component) and lysophosphatidic acid (LPA) use heterodimeric LPAR1-CD97 to ... α5β1 and αvβ3 integrins with an RGD downstream the EGF-like domains; and CD90 (Thy-1) with the GAIN domain. N-glycosylation of ... stimulates angiogenesis through binding integrin counterreceptors on endothelial cells". Blood. 105 (7): 2836-44. doi:10.1182/ ...
LAPs contain an RGD motif which is recognized by vast majority of αV containing integrins, and αVβ6 integrin can activate TGF- ... SMAD4 and forms a heterodimeric complex. This complex then enters the cell nucleus where it acts as a transcription factor for ... Conformation change mechanism pathway (without proteolysis) αVβ6 integrin was the first integrin to be identified as TGF-β1 ... May 1996). "Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation ...
This particular domain contains the RGD sequence important in the binding of ECM proteins to integrins found in cell membranes ... proteins require calcium cations to form homo and heterodimeric complexes between other ECM proteins. The complement control ...
glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters *SLC7A5 ...
This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes ... Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain ... 2002). "The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1". J. Cell Biol. 157 (3 ... 2003). "Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in ...
ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ... 2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52. doi:10.1161/01.ATV. ...
... including integrin β1. Rab11b-mediated control of integrin β1 surface expression allows efficient engagement with the brain ECM ... Our results identify Rab11b-mediated recycling of integrin β1 as regulating BCBM, and suggest that the recycleome, recycling- ... Integrins are heterodimeric proteins that mediate cell attachment to the ECM31. Of the integrins identified in our cell-surface ... n-p MDA-231 cells stained for integrin β1 and actin (phalloidin, to delineate cell boundaries) (n), or active integrin β1 and ...
αvβ3 integrin:. Transmembrane heterodimeric protein expressed on sprouting endothelial cells. ... E. Buommino, A. Baroni, N. Canozo et al., "Artemisinin reduces human melanoma cell migration by down-regulating αvβ3 integrin ... β3 integrins [93]. In hepatoma cells (HepG2 and SMMC 7721), treatment with 12.5 μM artemisinin depleted migration linked to a ...
Second, the functional β2 integrins exist only as heterodimeric complexes. Consequently, the formation of a functional integrin ... In addition, we show that increased adhesion is mediated by an induction of β2 integrin expression. The changes in β2 integrin ... The β2 integrins are heterodimeric glycoproteins that exist in four forms. Each form is composed of a unique α-subunit, encoded ... In addition to CD18, our studies revealed that at least one of the α subunits of the β2 integrin family is also induced by ...
heterodimeric receptors (4). Recently, two types of signaling by integrins have been extensively discussed: transmission of ... Key words: Integrin, Disintegrin, Leukocytes, Activation, Proliferation, Signal transduction. Integrins and signal transduction ... 1999). EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits alpha4 and alpha5 integrins in an RGD- ... Porter JC & Hogg N (1998). Integrins take partners: cross-talk between integrins and other membrane receptors. Trends in Cell ...
Crystal Structure of Heterodimeric Integrin aVb3. M. Judah Folkman, Childrens Hospital Boston, USA Anti-Angiogenic Therapy of ... Integrins and Rho Family GTPases in Mechanotransduction. Anne J. Ridley, Kings College London, UK Rho GTPase Signaling in ... Alpha-v Integrins as Negative Regulators of Angiogenesis. * Robert S. Kerbel, Sunnybrook Research Institute, Canada Metronomic ... Differential Raf-ERK Activation by Distinct Integrin/Growth Factor Receptor Pairs During Two Pathways of Angiogenesis: ...
Integrins are heterodimeric transmembrane glycoproteins that function as key adhesion and cell signalling receptors. A ... Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.. Jakubowska A, Gronwald J, Menkiszak J, ... functional polymorphism in the integrin beta3 subunit encoded by the ITGB3 gene, Leu33Pro, has been shown to modify a variety ...
Shedding of heterodimeric leukocyte integrin. Blood. 2006; 107: 3417-3418.. OpenUrlFREE Full Text ... Platelet Integrin Shedding. The function of both platelet and leukocyte integrins is directly relevant to the function of ... Evidence that β3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are ... Xi X, Bodnar RJ, Li Z, Lam SC, Du X. Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic ...
Encodes integrin alpha 11. Integrins are heterodimeric integral membrame proteins composed of an alpha chain and a beta chain. ...
... by binding to integrin receptors, heterodimeric integral membrane proteins (Bozyczko and Horwitz, 1986;Tomaselli et al., 1987; ... β1 Integrin can be found in extending filopodia. G, H, By 10 min, filopodia have fully extended, and β1 integrin is ... Left panels show F-actin, andright panels show β1 integrin. A, B, The growth cone has few filopodia, and β1 integrin is ... Thus, the integrin molecules we see receding are presumably bound to ligand that is not substrate-bound. Because integrin cross ...
Integrin Mediated Cell - Matrix Interaction Integrins are heterodimeric cell surface receptors for extracellular matrix ... The interaction of this protein with integrins requires a phorbol ester stimulation, a treatment known to cause integrin ... The interaction between integrins on cell surface and the extracellular matrix proteins are stabilized by cytoskeletal actin- ... One approach we have undertaken is to identify and characterize the proteins that bind to the cytoplasmic domain of integrins. ...
... in particular the αvβ3 integrin receptor. Such contrast agents may thus be used for diagnosis of for example malignant diseases ... Integrins are heterodimeric molecules in which the α- and β-subunits penetrate the cell-membrane lipid bilayer. The α-subunit ... The integrin αvβ3 is a member of a family of transmembrane proteins that act as receptors through which cells can adhere to the ... The integrin αvβ3 is one of the receptors that is known to be associated with angiogenesis. Stimulated endothelial cells appear ...
Integrins are ubiquitously expressed heterodimeric adhesion receptors consisting of α and β subunits. They exhibit two striking ... Integrins are ubiquitously expressed heterodimeric adhesion receptors consisting of α and β subunits. They exhibit two striking ... How active integrins revert to the inactive state, and how the weak α/β tail association is maintained is largely unknown. The ... How active integrins revert to the inactive state, and how the weak α/β tail association is maintained is largely unknown. The ...
... and integrin α1 mRNA levels were decreased (P , 0.05), while mRNA levels of tenascin C, tumor necrosis factor α, Toll-like ... Integrins are heterodimeric glycoproteins that contain non-covalently associated α and β subunit. They are expressed in basal ... The decrease of integrin α2 and β1 in lesioned footpads and increase of integrin α2 and β1 in healing footpads is consistent ... integrin α2 (ITGA2), and integrin β1 (ITGB1) were reduced (P , 0.03) in POS group at almost all points of evaluation when ...
Integrin signaling and heart failure Integrins are heterodimeric surface receptors consisting of one α-chain and one ß-chain. ... Integrin activation and atherosclerosis Although integrins are highly expressed on the cell surface, they do not bind their ... ß2 integrin activation on T cells is also a critical step during the process of extravasation and recruitment of T cells within ... Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris. Basic Res Cardiol ...
... as heterodimeric transmembrane receptors to mediate cell-cell and cell-matrix interactions ... Integrins are cell‐surface adhesion molecules formed from eight different β chains and 18 different α chains that assemble ... Integrin subunit pairings. There are 18 α‐ and 8 β‐integrin subunits from which 24 different functional integrins are currently ... Integrins are heterodimeric transmembrane receptors that mediate cell adhesion to the microenvironment. ...
Cells contact the ECM primarily through heterodimeric integral membrane proteins called integrins. Integrins connect the ECM to ... Cells contact the ECM primarily through heterodimeric integral membrane proteins called integrins. Integrins connect the ECM to ... Cells contact the ECM primarily through heterodimeric integral membrane proteins called integrins. Integrins connect the ECM to ... The IPP acts at the interface of the integrin/actin connection to regulate formation of focal adhesions and integrin signaling ...
Integrins are heterodimeric cell adhesion molecules formed by dimerization of 18 α-subunits and 8 β-subunits. Integrins αvβ3, α ... Similar to laminin, alteration in integrin expression is associated with tumor malignancy [82]. In fact, prosurvival integrin- ... integrin remains a potential target because GSCs also express high levels of α3 and α6 [85]. Overexpression of integrin α3 has ... G. Renner, H. Janouskova, F. Noulet et al., "Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic ...
Integrins are heterodimeric cell surface molecules involved in cell-cell interactions and cell-matrix interactions. Six of the ... Flow cytometry for integrin αvβ5. Cell surface expression of the integrin αvβ5 was assessed by flow cytometry as described ... The αvβ5 integrin mediates increased TGF-β activity in asthmatic cells, but not because of increased cell surface αvβ5 integrin ... Coimmunoprecipitation of integrin β5 with talin. The interaction of integrin β5 subunit with the cytoskeletal protein talin was ...
Integrins are heterodimeric glycoproteins that play a prominent role in the trafficking of lymphocytes (5). Experiments ... CD103 integrin-FITC (LF61) and CD49d integrin-FITC (44H6) were produced by Serotec. ... β7 integrin-R-PE (FIB504), CD103 integrin-PE (Ber-ACT8), CD45RO-FITC (UCHL1), and CD45RA-R-PE (HI100) were produced by BD ... CD103 is expressed by a large proportion of CD8+ IEL, compared with ,3% of CD8+ PBL (9). Unlike the integrin CD49d/β7, which ...
... integrin mediates cellular signaling events by forming αβ heterodimeric integrin receptors ( 8). Therefore, we examined the ... Furthermore, similar to the association of Ang2 with integrins in skeletal myocytes ( 25) and PG-MV/vesican with integrin in ... Among the integrin receptors, α3β1, α5β1, αvβ1, and α6β4 integrins are associated with enhanced cell motility and cancer ... Integrins are a diverse family of glycoproteins that form at least 25 heterodimeric receptors (one α subunit and one β subunit ...
Integrin Subunit Alpha 8, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin ... Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin ... Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, ...
... integrin mediates cellular signaling events by forming αβ heterodimeric integrin receptors ( 8). Therefore, we examined the ... Furthermore, similar to the association of Ang2 with integrins in skeletal myocytes ( 25) and PG-MV/vesican with integrin in ... Among the integrin receptors, α3β1, α5β1, αvβ1, and α6β4 integrins are associated with enhanced cell motility and cancer ... Integrins are a diverse family of glycoproteins that form at least 25 heterodimeric receptors (one α subunit and one β subunit ...
Integrins are heterodimeric, transmembrane receptors composed of α and β subunits that can be found in focal adhesions. Because ... S. J. Williams, B. G. White, and D. J. MacPhee "Expression of α5 Integrin (Itga5) Is Elevated in the Rat Myometrium During Late ... Expression of α5 Integrin (Itga5) Is Elevated in the Rat Myometrium During Late Pregnancy and Labor: Implications for ... S. J. Williams, B. G. White, D. J. MacPhee "Expression of α5 Integrin (Itga5) Is Elevated in the Rat Myometrium During Late ...
  • Integrin clusters in macromolecular complexes, ligand occupancy, and tyrosine phosphorylation are the key events that result in diverse processes such as cell migration and differentiation, tissue remodelling, cell proliferation, angiogenesis, and tumor cell invasion and metastasis (3,6). (scielo.br)
  • Although integrins are highly expressed on the cell surface, they do not bind their respective ligand unless activated from within the cell (inside-out signaling). (uni-heidelberg.de)
  • de Melker AA and Sonnenberg A (1999) Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events. (els.net)
  • In intact integrins, conformational signals are transmitted from inside activated lymphocytes that alter the conformation of the I domain and increase its affinity for ligand. (pnas.org)
  • To study the feasibility of Leucine-Aspartic Acid-Valine (LDV) as targeting ligand and drug carrier for targeted delivery to integrin α 4 β 1 over-expressing cancer cells. (springer.com)
  • Integrin (alpha v beta 3)-ligand interaction. (springer.com)
  • Normal gastrula cells lack integrin α4 and, correspondingly, are unable to adhere to the α4 ligand, the V-region of FN. (biologists.org)
  • Integrin activation is hypothesized to involve the propagation of a conformational change from the cytoplasmic domain, resulting in high-affinity ligand binding. (biologists.org)
  • Ligand recognition by the I domain-containing integrins. (thefullwiki.org)
  • 5 Integrin αvβ3 is overexpressed in the ligand-binding activated state on the surface of angiogenic endothelial cells in response to angiogenic growth factors. (pubmedcentralcanada.ca)
  • Correspondingly, intracellular signalling pathways can influence integrin function by increasing the affinity for ligand (affinity modulation) ( Shattil, 1999 ) and initiating clustering of active integrins into macromolecular structures such as focal adhesions/complexes and fibrillar adhesions ( Zamir and Geiger, 2001 ). (embopress.org)
  • The signaling mechanisms downstream from integrin-ligand binding are poorly understood, particularly in vascular smooth muscle cells (SMCs). (rupress.org)
  • In contrast, collagen type I (a β 1 -integrin ligand) did not induce NF-κB activity. (rupress.org)
  • Integrins require an activation step prior to ligand binding and signaling. (elifesciences.org)
  • The on-rate of the integrin-ligand binding reaction (also called integrin activation or inside-out signaling) is characterized by switching the unbound form of integrins from an inactive (low affinity) to an active (high affinity) conformation. (elifesciences.org)
  • Divalent cations such as Mg 2+ , Mn 2+ , and Ca 2+ and certain anti-integrin monoclonal antibodies (MAbs) have been shown to induce an increase in integrin affinity ( 47 ). (asm.org)
  • We used monoclonal antibodies to investigate the role of individual integrins in cytokine production. (bl.uk)
  • 1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. (els.net)
  • Within the Ig superfamily (IgSF), intercellular adhesion molecules (ICAMs) form a subfamily that binds the leukocyte integrin α L β 2 . (pnas.org)
  • Suehiro K, Mizuguchi J, Nishiyama K, Iwanaga S, Farrell DH, Ohtaki S. Fibrinogen binds to integrin alpha(5)beta(1) via the carboxyl-terminal RGD site of the Aalpha-chain. (springer.com)
  • Once leukocytes are guided to sites of infection, inflammation, or antigen presentation, integrins can participate in the initiation, maintenance, or termination of the immune and inflammatory responses. (scielo.br)
  • This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. (cancerindex.org)
  • The modulation of neutrophil activation through integrin-mediated pathways is important in the homeostatic control of the resolution of inflammatory states. (scielo.br)
  • In breast cancers, β 1 integrin activates ILK-mediated signaling pathways promoting cancer cell motility and metastasis ( 6 ). (aacrjournals.org)
  • Discover related pathways, diseases and genes to Integrin alpha 3/CD49c. (novusbio.com)
  • Integrins transmit signals across the plasma membrane, and engagement of integrins with the ECM activates numerous signalling pathways that influence a range of biological processes, including cell proliferation, migration and apoptosis ( Schwartz and Baron, 1999 ). (embopress.org)
  • Clearly any kinase found to associate with an integrin would be of interest in determining the pathways that regulate integrin function. (embopress.org)
  • In our laboratory we have found that integrins recycle in two time domains, and that the signalling pathways that regulate these processes are divergent ( Roberts et al , 2001 ). (embopress.org)
  • Analysis of candidate genes based on their known roles in integrin and TGFβ pathways failed to explain the observed phenotype. (arvojournals.org)
  • Basic understanding of various forms of functional interaction of integrin αvβ3 and active MMP-2 may be used to develop therapeutic approaches. (pubmedcentralcanada.ca)
  • However, the in vitro interaction between RKC-containing peptides and purified integrins was determined to be cation-independent, salt-sensitive and independent of RGD binding. (bl.uk)
  • Most monocytic cells will express a combination of the different CD23-binding integrins simultaneously and, therefore, the cytokine output of that cell will be the net result of the interaction of CD23 with a combination of integrins. (bl.uk)
  • Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion. (springer.com)
  • Here we report the crystal structure of EMS16 in complex with recombinant integrin alpha2-I domain that plays a central role in collagen binding. (rcsb.org)
  • The integrin-dependent adhesion of fetal β-cells to both collagen IV and vitronectin induces significant glucose-independent insulin secretion and a substantial reciprocal decline in insulin content. (diabetesjournals.org)
  • 1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins" . (wikidoc.org)
  • Disulfide bonds have been engineered to mimic conformational signals that stabilize integrins in the intermediate and open conformations ( 16 ). (pnas.org)
  • One important, unresolved issue is whether RGD peptides act solely by disrupting cell-ECM contacts or whether they provide direct signals to cells by binding to unoccupied integrins. (rupress.org)
  • In addition, during recirculation, T lymphocyte movement through distinct microenvironments is mediated by integrins, which are critical for cell cycle, differentiation and gene expression. (scielo.br)